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Conserved domains on  [gi|61602120|ref|YP_213962|]
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E1B 19K [simian adenovirus 1]

Protein Classification

Adeno_E1B_19K domain-containing protein( domain architecture ID 10483793)

Adeno_E1B_19K domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adeno_E1B_19K pfam01691
Adenovirus E1B 19K protein / small t-antigen; This family consists of adenovirus E1B 19K ...
 1-135 1.88e-63

Adenovirus E1B 19K protein / small t-antigen; This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen. E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein. The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.


:

Pssm-ID: 279955  Cd Length: 135  Bit Score: 191.32  E-value: 1.88e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61602120     1 MDLLGDLREFGVVRRLLELASDRTSKFWRFCFGSTLSNVLYRVKKEQETQFARLLADTPGVFVALDLGHHSLFQEKIIKN 80
Cdd:pfam01691   1 MDLLKILEDFKSLRRLLEGASNRTSWFWRFLFGGRLAKLVYRIKVEYEQEFEELLPECPGLFDSLNLGHTSLFEEKVVPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 61602120    81 LTFTSPGRTVASAAFITYILDQWSnSDSHLSWEYMLDYMAMALWRAMLRR-RVCIY 135
Cdd:pfam01691  81 LDFSSPGRTVASLAFLVFILDKWS-ADSHLSEDYLLDLLCAPLWRKLIRRkAVLLY 135
 
Name Accession Description Interval E-value
Adeno_E1B_19K pfam01691
Adenovirus E1B 19K protein / small t-antigen; This family consists of adenovirus E1B 19K ...
 1-135 1.88e-63

Adenovirus E1B 19K protein / small t-antigen; This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen. E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein. The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.


Pssm-ID: 279955  Cd Length: 135  Bit Score: 191.32  E-value: 1.88e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61602120     1 MDLLGDLREFGVVRRLLELASDRTSKFWRFCFGSTLSNVLYRVKKEQETQFARLLADTPGVFVALDLGHHSLFQEKIIKN 80
Cdd:pfam01691   1 MDLLKILEDFKSLRRLLEGASNRTSWFWRFLFGGRLAKLVYRIKVEYEQEFEELLPECPGLFDSLNLGHTSLFEEKVVPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 61602120    81 LTFTSPGRTVASAAFITYILDQWSnSDSHLSWEYMLDYMAMALWRAMLRR-RVCIY 135
Cdd:pfam01691  81 LDFSSPGRTVASLAFLVFILDKWS-ADSHLSEDYLLDLLCAPLWRKLIRRkAVLLY 135
 
Name Accession Description Interval E-value
Adeno_E1B_19K pfam01691
Adenovirus E1B 19K protein / small t-antigen; This family consists of adenovirus E1B 19K ...
 1-135 1.88e-63

Adenovirus E1B 19K protein / small t-antigen; This family consists of adenovirus E1B 19K protein or small t-antigen. The E1B 19K protein inhibits E1A induced apoptosis and hence prolongs the viability of the host cell. It can also inhibit apoptosis mediated by tumour necrosis factor alpha and Fas antigen. E1B 19K blocks apoptosis by interacting with and inhibiting the p53-inducible and death- promoting Bax protein. The E1B region of adenovirus encodes two proteins E1B 19K the small t-antigen as found in this family and E1B 55K the large t-antigen which is not found in this family; both of these proteins inhibit E1A induced apoptosis.


Pssm-ID: 279955  Cd Length: 135  Bit Score: 191.32  E-value: 1.88e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61602120     1 MDLLGDLREFGVVRRLLELASDRTSKFWRFCFGSTLSNVLYRVKKEQETQFARLLADTPGVFVALDLGHHSLFQEKIIKN 80
Cdd:pfam01691   1 MDLLKILEDFKSLRRLLEGASNRTSWFWRFLFGGRLAKLVYRIKVEYEQEFEELLPECPGLFDSLNLGHTSLFEEKVVPE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 61602120    81 LTFTSPGRTVASAAFITYILDQWSnSDSHLSWEYMLDYMAMALWRAMLRR-RVCIY 135
Cdd:pfam01691  81 LDFSSPGRTVASLAFLVFILDKWS-ADSHLSEDYLLDLLCAPLWRKLIRRkAVLLY 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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