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Conserved domains on  [gi|61102725|ref|NP_291029|]
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la-related protein 1 isoform 2 [Homo sapiens]

Protein Classification

LARP_1 and DM15 domain-containing protein( domain architecture ID 12959657)

protein containing domains PHA03247, LARP_1, LHP1, and DM15

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LARP_1 cd08037
La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related ...
 404-476 1.42e-45

La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related protein 1 (LARP1). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


:

Pssm-ID: 153406  Cd Length: 73  Bit Score: 157.76  E-value: 1.42e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 476
Cdd:cd08037    1 KDYIKRQIEYYFSVDNLERDFFLRRKMDEDGFLPVTLIASFHRVQALTTDISLIIKALKDSKVVEIIDMKIRR 73
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 926-964 8.76e-16

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


:

Pssm-ID: 128927  Cd Length: 39  Bit Score: 72.02  E-value: 8.76e-16
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 61102725     926 HFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEK 964
Cdd:smart00684    1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 885-925 1.22e-11

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


:

Pssm-ID: 128927  Cd Length: 39  Bit Score: 60.08  E-value: 1.22e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 61102725     885 FTQHVYHKYRRRCLNERKRLGigqSQEMNTLFRFWSFFLRD 925
Cdd:smart00684    2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
LHP1 super family cl34938
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 407-576 4.80e-09

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5193:

Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 60.06  E-value: 4.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  407 IKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKdskvvEIVDEKVRRREEPEKWPLP 486
Cdd:COG5193  274 KKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYRNLSFGGDKNLILAAMK-----EVVQNKATNHLEIALGSIE 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  487 PIVDYSQTDFSQLlncPEFVPRqhyqKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIevkkrprP 566
Cdd:COG5193  349 DAQKNEAKDFSPG---KKYFIR----KKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPYSYMGYPNFF-------P 414

                        170
                 ....*....|
gi 61102725  567 SPARPKKSEE 576
Cdd:COG5193  415 SNENGKKSQS 424
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 2-328 6.93e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 6.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725     2 ATQVEPLLPGGATLLQAEEHGGLVrKKPPPAPEGKGEPGpndvrggepdGSARRPRPPC-------AKPHKEGTGQQERE 74
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAA-PAPPAVPAGPATPG----------GPARPARPPTtagppapAPPAAPAAGPPRRL 2783

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725    75 SPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAPPPKVN-----PWTKNALPPVLTTVNGQSP----- 144
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAqptapPPPPGPPPPSLPLGGSVAPggdvr 2863

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   145 ---PEHSAPAKVVRAAVPKQRKGSKvgdfgdainwPTPGEIAHKSVQPQShKPQPTRKLPPKKDMKEQEKGEGSDSKESP 221
Cdd:PHA03247 2864 rrpPSRSPAAKPAAPARPPVRRLAR----------PAVSRSTESFALPPD-QPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   222 KTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLAS-RPTRP------PEPRHIPANRGEIKGSESA 294
Cdd:PHA03247 2933 PPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpAPSREapasstPPLTGHSLSRVSSWASSLA 3012

                         330       340       350
                  ....*....|....*....|....*....|....
gi 61102725   295 TYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSD 328
Cdd:PHA03247 3013 LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSD 3046
 
Name Accession Description Interval E-value
LARP_1 cd08037
La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related ...
 404-476 1.42e-45

La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related protein 1 (LARP1). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153406  Cd Length: 73  Bit Score: 157.76  E-value: 1.42e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 476
Cdd:cd08037    1 KDYIKRQIEYYFSVDNLERDFFLRRKMDEDGFLPVTLIASFHRVQALTTDISLIIKALKDSKVVEIIDMKIRR 73
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
401-477 7.80e-35

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 127.35  E-value: 7.80e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725     401 ELLKDYIKRQIEYYFSVDNLERDFFLRRKMDA-DGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVRRR 477
Cdd:smart00715    1 EELKQKIKKQVEYYFSDENLPRDKFLRKKMDKnDGYVPISTIASFKRVKSLTTDVNLIVEALRSSPKLEVSEdgLKVRRR 80
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 407-463 4.50e-25

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 99.03  E-value: 4.50e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 61102725    407 IKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLIFAALKD 463
Cdd:pfam05383    1 IKKQVEYYFSDENLPKDKFLRKQMDKdpDGYVPISVIASFKRMKKLTTDIDLIAEALRE 59
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 926-964 8.76e-16

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 72.02  E-value: 8.76e-16
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 61102725     926 HFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEK 964
Cdd:smart00684    1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 885-925 1.22e-11

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 60.08  E-value: 1.22e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 61102725     885 FTQHVYHKYRRRCLNERKRLGigqSQEMNTLFRFWSFFLRD 925
Cdd:smart00684    2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
LHP1 COG5193
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 407-576 4.80e-09

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 60.06  E-value: 4.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  407 IKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKdskvvEIVDEKVRRREEPEKWPLP 486
Cdd:COG5193  274 KKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYRNLSFGGDKNLILAAMK-----EVVQNKATNHLEIALGSIE 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  487 PIVDYSQTDFSQLlncPEFVPRqhyqKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIevkkrprP 566
Cdd:COG5193  349 DAQKNEAKDFSPG---KKYFIR----KKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPYSYMGYPNFF-------P 414

                        170
                 ....*....|
gi 61102725  567 SPARPKKSEE 576
Cdd:COG5193  415 SNENGKKSQS 424
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-328 6.93e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 6.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725     2 ATQVEPLLPGGATLLQAEEHGGLVrKKPPPAPEGKGEPGpndvrggepdGSARRPRPPC-------AKPHKEGTGQQERE 74
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAA-PAPPAVPAGPATPG----------GPARPARPPTtagppapAPPAAPAAGPPRRL 2783

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725    75 SPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAPPPKVN-----PWTKNALPPVLTTVNGQSP----- 144
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAqptapPPPPGPPPPSLPLGGSVAPggdvr 2863

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   145 ---PEHSAPAKVVRAAVPKQRKGSKvgdfgdainwPTPGEIAHKSVQPQShKPQPTRKLPPKKDMKEQEKGEGSDSKESP 221
Cdd:PHA03247 2864 rrpPSRSPAAKPAAPARPPVRRLAR----------PAVSRSTESFALPPD-QPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   222 KTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLAS-RPTRP------PEPRHIPANRGEIKGSESA 294
Cdd:PHA03247 2933 PPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpAPSREapasstPPLTGHSLSRVSSWASSLA 3012

                         330       340       350
                  ....*....|....*....|....*....|....
gi 61102725   295 TYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSD 328
Cdd:PHA03247 3013 LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSD 3046
 
Name Accession Description Interval E-value
LARP_1 cd08037
La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related ...
 404-476 1.42e-45

La RNA-binding domain of La-related protein 1; This domain is found in vertebrate La-related protein 1 (LARP1). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153406  Cd Length: 73  Bit Score: 157.76  E-value: 1.42e-45
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 476
Cdd:cd08037    1 KDYIKRQIEYYFSVDNLERDFFLRRKMDEDGFLPVTLIASFHRVQALTTDISLIIKALKDSKVVEIIDMKIRR 73
LARP_1_2 cd08034
La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in ...
 404-476 1.23e-44

La RNA-binding domain proteins similar to La-related proteins 1 and 2; This domain is found in proteins similar to vertebrate La-related proteins 1 and 2 (LARP1, LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153403  Cd Length: 73  Bit Score: 155.28  E-value: 1.23e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 476
Cdd:cd08034    1 KEYIKKQIEYYFSVDNLEKDFFLRRKMDPEGYLPIALIASFHRVQALTTDVNLILEALKDSTVVELVDEKVRC 73
LARP_2 cd08038
La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related ...
 404-476 1.03e-36

La RNA-binding domain of La-related protein 2; This domain is found in vertebrate La-related protein 2 (LARP2). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153407  Cd Length: 73  Bit Score: 132.77  E-value: 1.03e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRR 476
Cdd:cd08038    1 KEYIKRQIEYYFSTENLERDFFLRRKMDLQGFLPISLIAGFYRVQALTTNVDLILEALKDSTEVEIVDQKIRR 73
LA smart00715
Domain in the RNA-binding Lupus La protein; unknown function;
401-477 7.80e-35

Domain in the RNA-binding Lupus La protein; unknown function;


Pssm-ID: 128955 [Multi-domain]  Cd Length: 80  Bit Score: 127.35  E-value: 7.80e-35
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725     401 ELLKDYIKRQIEYYFSVDNLERDFFLRRKMDA-DGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVRRR 477
Cdd:smart00715    1 EELKQKIKKQVEYYFSDENLPRDKFLRKKMDKnDGYVPISTIASFKRVKSLTTDVNLIVEALRSSPKLEVSEdgLKVRRR 80
LAM cd07323
LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins ...
 404-476 2.14e-32

LA motif RNA-binding domain; This domain is found at the N-terminus of La RNA-binding proteins as well as in other related proteins. Typically, the domain co-occurs with an RNA-recognition motif (RRM), and together these domains function to bind primary transcripts of RNA polymerase III in the La autoantigen (Lupus La protein, LARP3, or Sjoegren syndrome type B antigen, SS-B). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153396  Cd Length: 75  Bit Score: 120.33  E-value: 2.14e-32
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVRR 476
Cdd:cd07323    1 LEKIKKQVEYYFSDENLCKDRFLRSLMDDDGWVPLSLLASFNRVKKLTTDVELILEALRDSSVVEVSEdgTKVRR 75
La pfam05383
La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well ...
 407-463 4.50e-25

La domain; This presumed domain is found at the N-terminus of La RNA-binding proteins as well as other proteins. The function of this region is uncertain.


Pssm-ID: 461635  Cd Length: 59  Bit Score: 99.03  E-value: 4.50e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 61102725    407 IKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLIFAALKD 463
Cdd:pfam05383    1 IKKQVEYYFSDENLPKDKFLRKQMDKdpDGYVPISVIASFKRMKKLTTDIDLIAEALRE 59
LARP_4_5_like cd08031
La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found ...
 404-475 1.18e-19

La RNA-binding domain of proteins similar to La-related proteins 4 and 5; This domain is found in proteins similar to La-related proteins 4 and 5 (LARP4, LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153400  Cd Length: 75  Bit Score: 84.03  E-value: 1.18e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVR 475
Cdd:cd08031    1 KELLKRQLEYYFSRENLANDAYLLSQMDSDQYVPIWTIANFNKIKKLTTDIDLIVEALRESPNVQVDEkgEKVR 74
LARP_6 cd08033
La RNA-binding domain of La-related protein 6; This domain is found in animal and plant ...
 404-476 1.14e-18

La RNA-binding domain of La-related protein 6; This domain is found in animal and plant proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153402  Cd Length: 77  Bit Score: 81.18  E-value: 1.14e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKM--DADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDE--KVRR 476
Cdd:cd08033    1 IQKIVKQVEYYFSDENLLKDAFLLKHVrrNKEGYVPIKLIASFKKVKALTRDWRVVAAALRRSSKLVVSEDgkKVRR 77
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 926-964 8.76e-16

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 72.02  E-value: 8.76e-16
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 61102725     926 HFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEK 964
Cdd:smart00684    1 NFNQNMYEEFRQLCLEDRKSLGRYELNCLYRFWSYGLRK 39
LARP_3 cd08028
La RNA-binding domain of La-related protein 3; This domain is found at the N-terminus of the ...
 403-476 1.06e-14

La RNA-binding domain of La-related protein 3; This domain is found at the N-terminus of the La autoantigen and similar proteins, and co-occurs with an RNA-recognition motif (RRM). Together these domains function to bind primary transcripts of RNA polymerase III at their 3' terminus and protect them from exonucleolytic degradation. Binding is specific for the 3'-terminal UUU-OH motif. The La autoantigen is also called Lupus La protein, LARP3, or Sjoegren syndrome type B antigen (SS-B).


Pssm-ID: 153397  Cd Length: 82  Bit Score: 70.02  E-value: 1.06e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61102725  403 LKDYIKRQIEYYFSVDNLERDFFLRRKM-DADGFLPITLIASFHRVQALTTDISLIFAALKDSK--VVEIVDE--KVRR 476
Cdd:cd08028    4 LEKKIIRQIEYYFGDFNLPRDKFLKEQIkEDDGWVPMEVMLKFNRLKSLSSDPEVIAKALKKSKsgLIEVSEDktKIRR 82
LARP_7 cd08032
La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key ...
 400-477 1.44e-14

La RNA-binding domain of La-related protein 7; LARP7 is a component of the 7SK snRNP, a key factor in the regulation of RNA polymerase II transcription. 7SK functionality is dependent on the presence of LARP7, which is thought to stabilize the 7SK RNA by interacting with its 3' end. The release of 7SK RNA from P-TEFb/HEXIM/7SK complexes activates the cyclin-dependent kinase P-TEFb, which in turn phosphorylates the C-terminal domain of RNA pol II and mediates a transition into productive transcription elongation.


Pssm-ID: 153401  Cd Length: 82  Bit Score: 69.97  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  400 QELLKDyIKRQIEYYFSVDNLERDFFLRRKMDA--DGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRR 477
Cdd:cd08032    3 KQLLAD-IAKQVDFWFGDVNLHKDRFLREQIEKsrDGYIDISLLVSFNKMKKLTTDGKLIARALKNSSVVELNLEGTRIR 81
LARP_4 cd08035
La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related ...
 404-475 1.98e-14

La RNA-binding domain of La-related protein 4; This domain is found in vertebrate La-related protein 4 (LARP4), also known as c-MPL binding protein. La-type domains often co-occur with RNA-recognition motifs (RRMs). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153404  Cd Length: 75  Bit Score: 69.30  E-value: 1.98e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVR 475
Cdd:cd08035    1 RECLKKQLEFCFSRENLSKDLYLISQMDSDQFVPIWTVANMEGIKKLTTDMDLILDVLRSSPMVQVDEtgEKVR 74
DM15 smart00684
Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown ...
 885-925 1.22e-11

Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function;


Pssm-ID: 128927  Cd Length: 39  Bit Score: 60.08  E-value: 1.22e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 61102725     885 FTQHVYHKYRRRCLNERKRLGigqSQEMNTLFRFWSFFLRD 925
Cdd:smart00684    2 FNQNMYEEFRQLCLEDRKSLG---RYELNCLYRFWSYGLRK 39
LA_like_fungal cd08029
La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in ...
 404-476 2.30e-11

La-motif domain of fungal proteins similar to the La autoantigen; This domain is found in fungal proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153398  Cd Length: 76  Bit Score: 60.39  E-value: 2.30e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKM--DADGFLPITLIASFHRVQALtTDISLIFAALKDSKVVEIVD--EKVRR 476
Cdd:cd08029    1 PEEIRKQVEFYFSDSNLPTDKFLWTLTggSNNGWVPIKTIASFKRMRRF-QPLEAVVEALRESELLEVSEdgENVRR 76
LARP_5 cd08036
La RNA-binding domain of La-related protein 5; This domain is found in vertebrate La-related ...
 404-475 3.09e-09

La RNA-binding domain of La-related protein 5; This domain is found in vertebrate La-related protein 5 (LARP5). A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153405  Cd Length: 75  Bit Score: 54.64  E-value: 3.09e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61102725  404 KDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVD--EKVR 475
Cdd:cd08036    1 RELLKKTLEFCLSRENLASDMYLISQMDSDQYVPIMTVANLDHIKKLSTDVDLIVDVLRSLPLVQVDEkgEKVR 74
LHP1 COG5193
La protein, small RNA-binding pol III transcript stabilizing protein and related ...
 407-576 4.80e-09

La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis];


Pssm-ID: 227520 [Multi-domain]  Cd Length: 438  Bit Score: 60.06  E-value: 4.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  407 IKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKdskvvEIVDEKVRRREEPEKWPLP 486
Cdd:COG5193  274 KKEQIEYYFSEENLKSDEFLRKKFKKAGFIPLSFIGKFYRNLSFGGDKNLILAAMK-----EVVQNKATNHLEIALGSIE 348

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  487 PIVDYSQTDFSQLlncPEFVPRqhyqKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIevkkrprP 566
Cdd:COG5193  349 DAQKNEAKDFSPG---KKYFIR----KKEWSEWLMESNFSEIADEKEKAKIEKLLGPNSLDPYSYMGYPNFF-------P 414

                        170
                 ....*....|
gi 61102725  567 SPARPKKSEE 576
Cdd:COG5193  415 SNENGKKSQS 424
LA_like_plant cd08030
La-motif domain of plant proteins similar to the La autoantigen; This domain is found in plant ...
 407-476 2.16e-08

La-motif domain of plant proteins similar to the La autoantigen; This domain is found in plant proteins related to the La autoantigen. A variety of La-related proteins (LARPs or La ribonucleoproteins), with differing domain architecture, appear to function as RNA-binding proteins in eukaryotic cellular processes.


Pssm-ID: 153399  Cd Length: 90  Bit Score: 52.39  E-value: 2.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725  407 IKRQIEYYFSVDNLERDFFLRRKM--DADGFLPITLIASFHRVQAL-------TTDISL-----IFAALKDSKVVEIVDE 472
Cdd:cd08030    5 VLRQVEFYFSDSNLPRDDFLLEEVeeDPDGMVSLALICSFSRMRSLlglgggkPEDVPEdtlkaVAEALRTSTLLKVSED 84


                 ....*.
gi 61102725  473 --KVRR 476
Cdd:cd08030   85 gkRVGR 90
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2-328 6.93e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 6.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725     2 ATQVEPLLPGGATLLQAEEHGGLVrKKPPPAPEGKGEPGpndvrggepdGSARRPRPPC-------AKPHKEGTGQQERE 74
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPALPAA-PAPPAVPAGPATPG----------GPARPARPPTtagppapAPPAAPAAGPPRRL 2783

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725    75 SPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAPPPKVN-----PWTKNALPPVLTTVNGQSP----- 144
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAqptapPPPPGPPPPSLPLGGSVAPggdvr 2863

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   145 ---PEHSAPAKVVRAAVPKQRKGSKvgdfgdainwPTPGEIAHKSVQPQShKPQPTRKLPPKKDMKEQEKGEGSDSKESP 221
Cdd:PHA03247 2864 rrpPSRSPAAKPAAPARPPVRRLAR----------PAVSRSTESFALPPD-QPERPPQPQAPPPPQPQPQPPPPPQPQPP 2932

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   222 KTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLAS-RPTRP------PEPRHIPANRGEIKGSESA 294
Cdd:PHA03247 2933 PPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpAPSREapasstPPLTGHSLSRVSSWASSLA 3012

                         330       340       350
                  ....*....|....*....|....*....|....
gi 61102725   295 TYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSD 328
Cdd:PHA03247 3013 LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSD 3046
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 26-303 3.16e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.60  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725    26 RKKPPPAPEGKgepgpNDVRGGEPDGSARRPRPPCAKPHKEGTGQ-----QERESPRPLQLPGAEGPAISDGEEGGGEpg 100
Cdd:PTZ00449  493 KKKLAPIEEED-----SDKHDEPPEGPEASGLPPKAPGDKEGEEGehedsKESDEPKEGGKPGETKEGEVGKKPGPAK-- 565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   101 agggaagaagagrrdfvEAPPPKVNPWTKNALPPVlTTVNGQSPPEHSAPAKVVRAAVPKQRKGSKVGDFGDAINWPTPG 180
Cdd:PTZ00449  566 -----------------EHKPSKIPTLSKKPEFPK-DPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRP 627

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61102725   181 EIAHKSVQPqshkPQPTRKLPPKKdmKEQEKG-EGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGnkhKWVPLQIDM 259
Cdd:PTZ00449  628 ESPKSPKRP----PPPQRPSSPER--PEGPKIiKSPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKET---KTTVVLDES 698

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 61102725   260 KPEVPREKLASRPTRP-PEPRHIPANRGEikgSESATYVPVAPPT 303
Cdd:PTZ00449  699 FESILKETLPETPGTPfTTPRPLPPKLPR---DEEFPFEPIGDPD 740
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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