NCBI Conserved Domain Search

Conserved domains on [gi|608620234|gb|AHW55213|]

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olfactory receptor family 5, partial [Vampyrum spectrum]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

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List of domain hits

Name

Accession

Description

Interval

E-value

7tm_GPCRs super family

cl28897

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...

1-239

6.00e-143

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

The actual alignment was detected with superfamily member cd15412:

Pssm-ID: 475119 Cd Length: 279 Bit Score: 401.01 E-value: 6.00e-143

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15412   32 HTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSVK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15412  112 MSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKETAMFIVAGFNLSSSLLIIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15412  192 ISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSKIVAVFYTFVSPMLNPLIYSLRN 270

Name

Accession

Description

Interval

E-value

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

1-239

6.00e-143

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 401.01 E-value: 6.00e-143

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15412   32 HTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSVK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15412  112 MSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKETAMFIVAGFNLSSSLLIIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15412  192 ISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSKIVAVFYTFVSPMLNPLIYSLRN 270

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

1-238

1.35e-29

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 111.82 E-value: 1.35e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234    1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:pfam13853  26 HQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKE-YTMIILGGINGTYSLTVV 159
Cdd:pfam13853 106 LTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNiYGLFVVTSTFGIDSLLIV 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  160 ItSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQ--GKMVAVFYTTVIPMLNPLIYSL 237
Cdd:pfam13853 186 L-SYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPllQIMMANAYLFFPPVLNPIVYSV 264


                  .
gi 608620234  238 R 238
Cdd:pfam13853 265 K 265

Name

Accession

Description

Interval

E-value

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

1-239

6.00e-143

Pssm-ID: 320534 Cd Length: 279 Bit Score: 401.01 E-value: 6.00e-143

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15412   32 HTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSVK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15412  112 MSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKETAMFIVAGFNLSSSLLIIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15412  192 ISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPSEESVEQSKIVAVFYTFVSPMLNPLIYSLRN 270

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

1-239

1.75e-128

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 363.75 E-value: 1.75e-128

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15230   32 HTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15230  112 MSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINELVLFAFSGFIGLSTLLIIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15230  192 ISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

1-239

2.23e-111

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 320.58 E-value: 2.23e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd13954   32 HTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPLHYPTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd13954  112 MNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVIFILAGFVGLGSFLLTL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd13954  192 VSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

1-239

1.36e-106

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 308.87 E-value: 1.36e-106

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15413   32 QTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15413  112 MSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHEKELIILIFAGFNLISSLLIVL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15413  192 VSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSSHSLDTDKMASVFYTLVIPMLNPLIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

1-239

5.00e-104

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 303.13 E-value: 5.00e-104

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15943   46 HTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15943  126 MSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEIL 205

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15943  206 VSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRN 284

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

1-239

2.70e-102

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 298.08 E-value: 2.70e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15411   32 HTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTVV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15411  112 MSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAGLTLVGSLLIIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15411  192 VSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSYSLGQDKVASVFYTVVIPMLNPLIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

1-239

9.04e-102

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 296.67 E-value: 9.04e-102

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15225   32 HTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTLI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15225  112 MNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASVLVILVPFLLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15225  192 VSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSSYSPETDKLLSLFYTVVTPMLNPIIYSLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

1-239

7.43e-101

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 294.95 E-value: 7.43e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15410   45 HTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15410  125 MSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIIL 204

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15410  205 TSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRN 283

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

1-239

8.83e-101

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 294.23 E-value: 8.83e-101

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15408   45 HTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15408  125 MSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVIL 204

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15408  205 ISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFYGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRN 283

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

1-239

1.75e-98

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 288.44 E-value: 1.75e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15419   32 HTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAYDRFIAICNPLLYPVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15419  112 MSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVMFVLCGLIIVSTILVIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15419  192 VSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAVSSPEQSKVVSVFYTLVIPMLNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

1-239

4.65e-98

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 287.23 E-value: 4.65e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15417   32 HTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAYDRYVAICNPLLYSVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15417  112 MSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFISQVVLFLVAVLFGVFSVLVVL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15417  192 ISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSSHSQDQDKVASVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

1-239

1.17e-96

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 283.49 E-value: 1.17e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15416   32 HTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAYDRYVAICNPLLYSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15416  112 MSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSGIIILVTVLTII 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15416  192 ISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYSMDQNKVVSVFYMVVIPMLNPLIYSLRN 270

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

1-239

2.30e-95

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 280.26 E-value: 2.30e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15235   33 HTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYATV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15235  113 MSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLIV 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15235  193 LSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSSYSADKDRVATVMYTVVTPMLNPFIYSLRN 271

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

1-239

2.98e-95

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 279.87 E-value: 2.98e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15229   32 HTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15229  112 MSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSFLLTL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15229  192 VSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASSSVLDRVFSIQYSILTPMLNPIIYSLKN 270

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

1-239

6.06e-95

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 278.98 E-value: 6.06e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15912   32 HTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHYPTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15912  112 MNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLDFILASVVLLGSLLLTI 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15912  192 VSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQSSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

1-239

6.58e-95

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 279.31 E-value: 6.58e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15414   32 HTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASMAYDRYVAICNPLLYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15414  112 MSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWVLFIMAGALGVLSGLIIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15414  192 VSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSSLDLDKVVSVFYTAVIPMLNPLIYSLRN 270

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

1-239

1.70e-94

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 278.14 E-value: 1.70e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15409   32 HTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPVV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15409  112 MSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINELVLFIFSGSIQVFTILTVL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15409  192 ISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALDQDMMDSLFYTIVIPLLNPFIYSLRN 270

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

1-239

1.39e-93

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 275.69 E-value: 1.39e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15237   32 HTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15237  112 MSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSVLVLLIPFSLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15237  192 ASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHSPDQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

1-239

1.91e-92

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 273.47 E-value: 1.91e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15406   41 HTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVT 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15406  121 MSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAIL 200

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15406  201 ISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRN 279

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

1-239

5.37e-92

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 271.83 E-value: 5.37e-92

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15231   32 HTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAYDRYVAICNPLHYAVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15231  112 MSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSLNEVLLLVASVFIGLTPFLFIV 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15231  192 ISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGYSLDKDTLISVLYSIVTPMLNPIIYSLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

1-239

1.13e-91

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 270.51 E-value: 1.13e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15911   32 HTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYASL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15911  112 MNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTLPPFLLTL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15911  192 TSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

1-239

3.41e-90

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 267.11 E-value: 3.41e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15421   32 HTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLRYPVL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15421  112 MSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKLSCADTSAYETVVYVSGVLFLLIPFSLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15421  192 ASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHSPEQDKVVSVFYTILTPMLNPLIYSLRN 270

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

1-239

4.39e-90

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 266.97 E-value: 4.39e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15415   32 HTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAYDRYVAICNPLLYTVA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15415  112 MTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINELLLLTFSGVIAMSTLLTII 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15415  192 ISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYSLEQEKVSAVFYTLVIPMLNPLIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

1-239

4.89e-90

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 266.40 E-value: 4.89e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15918   32 HTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMAYDRYVAICHPLHYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15918  112 MSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLNELVILVLGGLVGLVPFLCIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15918  192 VSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHSASKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

1-239

5.62e-90

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 266.59 E-value: 5.62e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15407   32 HTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASMAYDRHAAVCKPLHYTTT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15407  112 MTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHISEIVLFFLASFNVFFALLVIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15407  192 ISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHSMDTDKMASVFYTMVIPMLNPLVYSLRN 270

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

1-239

8.37e-90

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 266.61 E-value: 8.37e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15945   45 HTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15945  125 MSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAII 204

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15945  205 ISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRN 283

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

1-239

1.20e-89

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 265.63 E-value: 1.20e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15431   32 HTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMAYDRFVAICNPLRYTLI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLwTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15431  112 MSWRVCIQLAAGSWVSAFLLTVIPVL-TMPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMFATSIFTLLLPFSFIL 190

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15431  191 VSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSSSDQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

1-239

3.00e-85

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 254.47 E-value: 3.00e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15947   32 HTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAFDRYVAVCRPLHYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15947  112 MHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKLACVDTTFNELELFVASVFFLLVPLSLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15947  192 VSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

1-239

1.24e-84

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 253.55 E-value: 1.24e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15944   45 HTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15944  125 MSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIIL 204

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15944  205 ISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFYGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRN 283

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

1-239

1.44e-83

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 250.25 E-value: 1.44e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15232   32 HTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15232  112 MRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIMAFVADVFFGVGNFLLTL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15232  192 TSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

1-239

1.55e-83

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 249.82 E-value: 1.55e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15939   32 GSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15939  112 MNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLKLACTDTYVIGLLVVANSGLICLLSFLILL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAiLRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEqgKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15939  192 ISYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTFPID--KVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

1-239

3.90e-83

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 249.31 E-value: 3.90e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15418   33 HTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAYDRYVAICNPLLYSSA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15418  113 MSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELILYFILGFNVIAPTALIL 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15418  193 ASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPSSSHTPDRDKVVALFYTVVNPLLNPLIYSLRN 271

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

1-239

1.84e-82

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 247.37 E-value: 1.84e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15227   32 HTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHYEVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15227  112 MNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFVFII 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15227  192 VSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSPSLLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

1-239

3.18e-82

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 246.86 E-value: 3.18e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15420   32 HTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15420  112 MNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCVFILLGPFSLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15420  192 ISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNSAEQEKILSLFYSLFNPMLNPLIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

1-239

3.84e-82

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 246.43 E-value: 3.84e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15224   32 HKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYDRYVAICHPLRYPVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15224  112 MTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDFILALIILLVPLLVTV 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15224  192 ASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAISSFDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

1-239

2.20e-81

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 244.62 E-value: 2.20e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15429   32 HTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVMAYDRYVAVCHPLRYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15429  112 MSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEVAILVSSVVVLLTPCFLVL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15429  192 LSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSSALQEKMISLFYAVVTPMLNPLIYSLRN 270

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

1-239

3.19e-81

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 244.20 E-value: 3.19e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15430   32 HTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPII 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15430  112 MNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPLLLIC 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15430  192 ISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

1-239

5.79e-80

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 241.13 E-value: 5.79e-80

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15434   32 HTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTVV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15434  112 MHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLACVDTTAYEATIFALGVFILLFPLSLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15434  192 VSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQDQGKFLTLFYTIVTPSLNPLIYTLRN 270

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

1-239

1.44e-78

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 237.10 E-value: 1.44e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15226   32 HSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15226  112 MSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYVLELMVVANSGLISLVCFLLLL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAIlRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEqgKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15226  192 ISYIVILVTV-RKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPVD--KFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

1-239

1.52e-76

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 232.37 E-value: 1.52e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15432   32 HTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAFDRFAAICQPLHYSVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15432  112 MHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISVLLLLIPLGLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15432  192 ISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSNSSHDRGKMVALFYGIITPMLNPLIYTLRN 270

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

1-239

2.63e-76

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 231.81 E-value: 2.63e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15915   32 HSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAYDRYVAICNPLRYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15915  112 MNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSLNLWLLNIVTGSIALGTFILTL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRM-HSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15915  192 LSYIYIISFLLLKvRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSGDSLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

1-239

2.81e-74

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 226.53 E-value: 2.81e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15405   32 HTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDRYVAICNPLLYTVT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15405  112 MSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYVNELVVFVVVGINIIVPSVTIF 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15405  192 ISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGSVNQGKVSSVFYTNVVPMLNPLIYSLRN 270

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

1-239

1.54e-73

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 224.76 E-value: 1.54e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15234   32 HTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15234  112 MNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKLACSDTLINNILIYLATVIFGGIPLSGII 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15234  192 FSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHSSRKTAVASVMYTVVTPMLNPFIYSLRN 270

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

1-239

7.87e-72

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 220.01 E-value: 7.87e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15940   32 HTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAYDRYVAICNPLHYPTV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15940  112 MNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDILIVSNSGLISLVCFVALL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAiLRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEqgKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15940  192 GSYIVILVS-LRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSED--KVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

1-239

2.13e-71

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 219.28 E-value: 2.13e-71

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15233   32 HTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAYDRYLAICQPLTYSVR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15233  112 MSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLFVFAFFMALAPCVLIV 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15233  192 VSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVYSSDKDKVIGILNTVLSPMLNPLIYSLRN 270

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

1-239

8.74e-70

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 215.37 E-value: 8.74e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15424   32 HTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYAAA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15424  112 MGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVFGAGVLILLVPLSVIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15424  192 TSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGSTPDRDKQIAVFYIVITPLLNPIIYTLRN 270

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

1-239

2.25e-69

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 213.73 E-value: 2.25e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15936   32 HTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15936  112 MNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLELLMVSNSGLVTLLIFFILL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAIlRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEqgKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15936  192 ISYTVILVKI-RTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPMD--KAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

1-239

4.09e-69

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 213.39 E-value: 4.09e-69

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15914   32 HTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPSI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15914  112 MTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVDFVIHAVIILLTFLLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15914  192 LSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYSLDYDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

1-239

1.02e-68

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 212.18 E-value: 1.02e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15913   32 HTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAFDRYLAICRPLHYPTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15913  112 MTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPGTELICYTLSSLIIFGTFLFIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15913  192 GSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNSTGMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

1-239

3.63e-67

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 208.46 E-value: 3.63e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLS-EAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGS 79
Cdd:cd15916   32 HRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpGGKVISFGGCVAQLYFFHFLGSTECFLYTLMAYDRYLAICHPLHYPT 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  80 RMSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVV 159
Cdd:cd15916  112 IMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINELVIFASIGVVALGCFILI 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 160 ITSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEqgKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15916  192 LLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKEALD--GVIAVFYTVVTPLLNPLIYTLRN 269

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

2-239

9.52e-67

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 207.03 E-value: 9.52e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   2 SPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSRM 81
Cdd:cd15938   33 SPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTTIM 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  82 SRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVIT 161
Cdd:cd15938  113 SRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTELLMVSNSGLISTVCFVVLVT 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 608620234 162 SYLFILIailRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEqgKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15938  193 SYTTILV---TIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPVD--KHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

1-239

3.43e-66

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 206.18 E-value: 3.43e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15428   32 HTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVMSYDRYVAICLPLRYSLI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15428  112 MTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEMAMFIMCVFTLVLPVLLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15428  192 ASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSSTSKEYDKMISVFYIIVTPMLNPLIYSLRN 270

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

1-239

4.20e-66

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 205.79 E-value: 4.20e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15946   32 HTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAYDRYVAICHPLRYKVI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15946  112 MSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVDFVLGVIVLVVPLSLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15946  192 ASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNYSPERDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

1-239

2.25e-65

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 203.85 E-value: 2.25e-65

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15236   32 HTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAYDRYVAICHPLHYTAI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15236  112 MRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGGLLFVLPLLLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15236  192 GSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIVASVMYTVVTPMLNPFIYSLRN 270

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

1-239

1.07e-63

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 199.58 E-value: 1.07e-63

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15228   32 HTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAYDRYVAICHPLRYLLI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15228  112 MNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSFTNVGLVPLTCFLLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRptEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15228  192 ASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQP--TPSPVLVTPVQIFNNVVTPMLNPLIYTLRN 268

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

1-239

3.53e-62

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 195.78 E-value: 3.53e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15433   32 HTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAFDRYAAVCRPLHYAAL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15433  112 MSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQMFVARVVILLLPAALIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15433  192 GSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRYSQAHGKFVSLFYTVMTPALNPLIYTLRN 270

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

1-239

8.30e-62

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 194.96 E-value: 8.30e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15942   32 HKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVMAYDRFLAICKPLHYSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15942  112 MNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFNELVTFIDIGLVAMTCFLLIL 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVeqGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15942  192 MSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDPL--DGVVAVFYTTVTPLLNPVIYTLRN 268

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

2-239

1.19e-60

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 191.52 E-value: 1.19e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   2 SPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSRM 81
Cdd:cd15935   34 SPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVM 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  82 SRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVIT 161
Cdd:cd15935  114 NRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEVLMVANSGLLSLVCFLVLLV 193

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 608620234 162 SYLFILIAiLRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEqgKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15935  194 SYGIILTT-LRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSSVD--KVASVFYTLITPALNPLIYTLRN 268

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

3-239

5.36e-60

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 190.44 E-value: 5.36e-60

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   3 PMYFLLSHLSFVDVWFSSNVTPKMLENLLS-EAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSRM 81
Cdd:cd15941   35 PMYHFLGHLSFLDACLSSVTVPKVLAGLLTlSGRTISFEGCVVQLYAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAM 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  82 SRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVIT 161
Cdd:cd15941  115 NRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELVILANIGIVAAGCFLLIVI 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 608620234 162 SYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLrRPTEESVEQGkMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15941  195 SYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYL-QPSSSQAGAG-APAVFYTIVTPMLNPFIYTLRN 270

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

2-239

1.49e-56

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 181.09 E-value: 1.49e-56

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   2 SPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSRM 81
Cdd:cd15937   33 SPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAYDRYVAICKPLHYTTVV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  82 SRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVIT 161
Cdd:cd15937  113 NRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELLMFSNSGLVILLCFLLLLI 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 608620234 162 SYLFILiAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRrpTEESVEQGKMVAVFYTTVIPMLNPLIYSLRN 239
Cdd:cd15937  193 SYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYAR--PFRSFPMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

1-239

3.62e-49

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 162.46 E-value: 3.62e-49

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15223   32 HQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPSI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15223  112 ITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYGLAVAWLIVGSDIILIF 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQ--GKMVAVFYTTVIPMLNPLIYSLR 238
Cdd:cd15223  192 FSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIPPdvHVLLSVLYILIPPALNPIIYGVR 271


                 .
gi 608620234 239 N 239
Cdd:cd15223  272 T 272

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

1-239

2.63e-45

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 152.44 E-value: 2.63e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15917   32 HEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15917  112 LTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSIYGLFVALLIVGFDLLFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQ--GKMVAVFYTTVIPMLNPLIYSLR 238
Cdd:cd15917  192 LSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPPhvHILLANLYLLLPPMLNPIVYGVR 271


                 .
gi 608620234 239 N 239
Cdd:cd15917  272 T 272

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

1-238

1.12e-43

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 148.33 E-value: 1.12e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15950   32 HEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGT-FVKEYTMIILGGINGTYSLTVV 159
Cdd:cd15950  112 LTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPrPSSLYSITGSTLVVGTDSAFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 160 ItSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFY-GTLMFMYLRR-PTEESVEQGKMVAVFYTTVIPMLNPLIYSL 237
Cdd:cd15950  192 V-SYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYiPGLLSIYTQRfGQGVPPHTQVLLADLYLLVPPMLNPIIYGM 270


                 .
gi 608620234 238 R 238
Cdd:cd15950  271 R 271

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

1-238

8.33e-40

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 138.19 E-value: 8.33e-40

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15221   32 HEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAMAFDRYVAICYPLRYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTfvkeytmiilgGINGTYSLTVVI 160
Cdd:cd15221  112 LTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADI-----------TVNIWYGLTVAL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 -----------TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGK--MVAVFYTTVI 227
Cdd:cd15221  181 ltvgldvvliaVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHIPRHVhiLLANLYVLVP 260

                        250
                 ....*....|.
gi 608620234 228 PMLNPLIYSLR 238
Cdd:cd15221  261 PMLNPIVYGVK 271

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

1-238

1.96e-39

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 137.13 E-value: 1.96e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15952   32 HQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGtYSLTVVI 160
Cdd:cd15952  112 LTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIRINIIYGLFAISVLV-LDVILIA 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQ--GKMVAVFYTTVIPMLNPLIYSLR 238
Cdd:cd15952  191 LSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRyiHILLANLYVVLPPMLNPVIYGVR 270

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

1-239

2.10e-39

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 137.09 E-value: 2.10e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15951   32 HEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMALDRYVAICNPLRHSTI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15951  112 LTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRVSRAYGLSVAFLVGGLDVIFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQ--GKMVAVFYTTVIPMLNPLIYSLR 238
Cdd:cd15951  192 VSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPPhvHILIANVYLLVPPMLNPIIYGVR 271


                 .
gi 608620234 239 N 239
Cdd:cd15951  272 T 272

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

1-239

1.00e-37

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 132.77 E-value: 1.00e-37

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15953   32 HKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAFDRYVAICNPLRYATI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFvkeytmiilggINGTYSLTVVI 160
Cdd:cd15953  112 LTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTT-----------INRIYGLVVAL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 -----------TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYL--RRPTEESVEQGKMVAVFYTTVI 227
Cdd:cd15953  181 lvvgldllliaLSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGIAPHIHIILANLYLLVP 260

                        250
                 ....*....|..
gi 608620234 228 PMLNPLIYSLRN 239
Cdd:cd15953  261 PMLNPIIYGVKT 272

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

1-238

1.76e-36

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 129.54 E-value: 1.76e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15222   32 HEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYASI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 M--SRVVCVRLVSFpyIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKE-YTMIILGGINGTYSLT 157
Cdd:cd15222  112 LtnSRIAKIGLAIV--LRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSiYGLFVVLSTMGLDSLL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 158 VVItSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLM--FMYLRRPTEESVEQGKMVAVFYTTVIPMLNPLIY 235
Cdd:cd15222  190 ILL-SYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIglSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIY 268


                 ...
gi 608620234 236 SLR 238
Cdd:cd15222  269 SVK 271

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

1-238

5.07e-33

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 120.74 E-value: 5.07e-33

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15956   32 HQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAMALDRFVAICNPLHYATI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15956  112 LTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGLALALFIGGGDVLFIA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGKMV--AVFYTTVIPMLNPLIYSLR 238
Cdd:cd15956  192 YSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVPSAAHVllSNLYLLLPPALNPIVYGIR 271

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

1-238

1.15e-32

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 119.62 E-value: 1.15e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15948   33 HEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATI 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15948  113 LTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFII 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYL--RRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLR 238
Cdd:cd15948  193 LSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhRFARHVAPHVHILLANFYLLFPPMMNPIVYGVK 272

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

1-238

1.86e-32

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 119.16 E-value: 1.86e-32

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15954   32 HRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYATI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15954  112 LTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRVDAIYGLMVALLIGGFDILCIS 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYL-RRPTEESVEQGK--MVAVFYTTVIPMLNPLIYSL 237
Cdd:cd15954  192 VSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFaHRFGGHHITPHIhiIMANLYLLLPPMMNPIVYGV 271


                 .
gi 608620234 238 R 238
Cdd:cd15954  272 K 272

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

1-238

1.35e-29

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 111.82 E-value: 1.35e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234    1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:pfam13853  26 HQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTTI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKE-YTMIILGGINGTYSLTVV 159
Cdd:pfam13853 106 LTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNiYGLFVVTSTFGIDSLLIV 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  160 ItSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQ--GKMVAVFYTTVIPMLNPLIYSL 237
Cdd:pfam13853 186 L-SYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPllQIMMANAYLFFPPVLNPIVYSV 264


                  .
gi 608620234  238 R 238
Cdd:pfam13853 265 K 265

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

1-238

2.23e-29

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 111.41 E-value: 2.23e-29

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15949   48 HQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTI 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVVI 160
Cdd:cd15949  128 LTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIV 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYL--RRPTEESVEQGKMVAVFYTTVIPMLNPLIYSLR 238
Cdd:cd15949  208 LSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLihRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVR 287

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

1-239

8.54e-26

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 101.38 E-value: 8.54e-26

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd15955   32 HQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMALDRYVAICHPLRHSSI 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYG-FLTSLAATLWTYGLYFCGKIEINHFYCADPPLIKIACAGTFVKEYTMIILGGINGTYSLTVV 159
Cdd:cd15955  112 LTPQVLLGIGVLVVVRAvVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKLAADDVRVNKIYGLFVAFSILGFDIIFI 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 160 ITSYLFILIAILRMHSAEGRRKAFSTCGSHLTVVIIFYGTLMFMYLRRPTEESVEQGK--MVAVFYTTVIPMLNPLIYSL 237
Cdd:cd15955  192 TTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVAPYVhiLLSNLYLLVPPVLNPIVYGV 271


                 ..
gi 608620234 238 RN 239
Cdd:cd15955  272 KT 273

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

1-235

1.80e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 97.75 E-value: 1.80e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234    1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAK-TISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGS 79
Cdd:pfam00001  16 RTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   80 RMSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCgkiEINHFYCADPPLIKIACAGTFVkeYTMIILGGIngtYSLTVV 159
Cdd:pfam00001  96 RRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVP---EGNVTVCFIDFPEDLSKPVSYT--LLISVLGFL---LPLLVI 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  160 ITSYLFILIAILRMHSAEGR-------RKAFSTCGSHLTVVIIFYGTLMFMYLRRPT------EESVEQGKMVAVFYTTV 226
Cdd:pfam00001 168 LVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLaldcelSRLLDKALSVTLWLAYV 247


                  ....*....
gi 608620234  227 IPMLNPLIY 235
Cdd:pfam00001 248 NSCLNPIIY 256

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

1-239

1.15e-09

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 56.91 E-value: 1.15e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd00637   30 RTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATLWTYGLYFCGKIEINHFYCADpplikiacagTFVKEYTMIILgGINGTYSLTVVI 160
Cdd:cd00637  110 FTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDL----------TLSKAYTIFLF-VLLFLLPLLVII 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 161 TSYLFILIaILRMHSAEGRRKAFSTCGSH------------LTVVIIF------YGTLMFMYLRRPTEESVEQG-KMVAV 221
Cdd:cd00637  179 VCYVRIFR-KLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFllcwlpYFILLLLDVFGPDPSPLPRIlYFLAL 257

                        250
                 ....*....|....*...
gi 608620234 222 FYTTVIPMLNPLIYSLRN 239
Cdd:cd00637  258 LLAYLNSAINPIIYAFFN 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

1-103

6.12e-06

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 46.05 E-value: 6.12e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYgSR 80
Cdd:cd14969   32 RTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKA-FR 110

                         90       100
                 ....*....|....*....|...
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLA 103
Cdd:cd14969  111 LSKRRALILIAFIWLYGLFWALP 133

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

5-239

3.63e-05

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 43.71 E-value: 3.63e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   5 YFLLShLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSRMSRV 84
Cdd:cd14967   36 YFIVS-LAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  85 VCVRLVSFPYIYGFLTSLAATLWTYGLYfcgkieinhfycaDPPLIKIACAGTFVKEYtMIILGGINGTYSLTVVITSYL 164
Cdd:cd14967  115 RALIMIAAVWVYSLLISLPPLVGWRDET-------------QPSVVDCECEFTPNKIY-VLVSSVISFFIPLLIMIVLYA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 165 FILIaILRMHsaegrRKAFSTCGshlTVVIIFYGT---LMFMYLRRP--TEESVEQGKMVAVFYTTVI-PMLNPLIYSLR 238
Cdd:cd14967  181 RIFR-VARRE-----LKAAKTLA---IIVGAFLLCwlpFFIIYLVSAfcPPDCVPPILYAVFFWLGYLnSALNPIIYALF 251


                 .
gi 608620234 239 N 239
Cdd:cd14967  252 N 252

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

42-99

2.38e-03

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 38.30 E-value: 2.38e-03

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 608620234  42 CLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGSRMSRVVCVRLV----SFPYIYGFL 99
Cdd:cd15055   73 CKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICIclcwFVSALYSSV 134

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

1-239

6.78e-03

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 36.89 E-value: 6.78e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTISYNGCLVQCFFFIALVhVELFILAVMAFDRYMAIGQPLLYGSR 80
Cdd:cd14972   30 HKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLL-ASAYSLLAIAVDRYISIVHGLTYVNN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234  81 MSRVVCVRLVSFPYIYGFLTSLAATL-WTYGLYFCGKIeinhfycadpplikIACAGTFVKEYTMIILGgingTYSLTVV 159
Cdd:cd14972  109 VTNKRVKVLIALVWVWSVLLALLPVLgWNCVLCDQESC--------------SPLGPGLPKSYLVLILV----FFFIALV 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234 160 ITSYLFILI-AILRMHSAEGRRKAFSTCGSHL--------TVVIIF------YGTLMFMYLRRPTeeSVEQGKMVAVFYT 224
Cdd:cd14972  171 IIVFLYVRIfWCLWRHANAIAARQEAAVPAQPstsrklakTVVIVLgvflvcWLPLLILLVLDVL--CPSVCDIQAVFYY 248

                        250       260
                 ....*....|....*....|
gi 608620234 225 TVIPML-----NPLIYSLRN 239
Cdd:cd14972  249 FLVLALlnsaiNPIIYAFRL 268

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

1-90

9.55e-03

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 36.67 E-value: 9.55e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 608620234   1 HSPMYFLLSHLSFVDVWFSSNVTPKMLENLLSEAKTI-SYNGCLVQCFFFIALVHVELFILAVMAFDRYMAIGQPLLYGS 79
Cdd:cd15005   32 HRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGWIyGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAK 111

                         90
                 ....*....|.
gi 608620234  80 RMSRVVCVRLV 90
Cdd:cd15005  112 RMTFWTCLAVI 122

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

60-107

9.89e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 36.18 E-value: 9.89e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 608620234  60 LAVMAFDRYMAIGQPLLYGSRMSRVVCVRLVSFPYIYGFLTSLAATLW 107
Cdd:cd15067   91 LCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIAW 138

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01