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Conserved domains on  [gi|60593940]
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Chain A, Crystal structure of PH1933 from Pyrococcus horikoshii OT3

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 40-141 8.68e-20

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 79.10  E-value: 8.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940    40 DYARNYIKWCWKKASDGFFVAKVGDKIVGFIVCDKDWfskyEGRIVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN- 118
Cdd:pfam00583  18 DEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIID----DEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGc 93

                          90       100
                  ....*....|....*....|...
gi 60593940   119 DTIELWVGEKNYGAMNLYEKFGF 141
Cdd:pfam00583  94 ERIFLEVAADNLAAIALYEKLGF 116
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 40-141 8.68e-20

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 79.10  E-value: 8.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940    40 DYARNYIKWCWKKASDGFFVAKVGDKIVGFIVCDKDWfskyEGRIVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN- 118
Cdd:pfam00583  18 DEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIID----DEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGc 93

                          90       100
                  ....*....|....*....|...
gi 60593940   119 DTIELWVGEKNYGAMNLYEKFGF 141
Cdd:pfam00583  94 ERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
57-154 4.04e-17

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 73.49  E-value: 4.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  57 FFVAKVGDKIVGFIVCDkdWFSKYEGRIVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKNYGAMNL 135
Cdd:COG1247  54 VLVAEEDGEVVGFASLG--PFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGyRRLVAVVLADNEASIAL 131

                        90       100
                ....*....|....*....|....*.
gi 60593940 136 YEKFGFKKVG-------KSGIWVRMI 154
Cdd:COG1247 132 YEKLGFEEVGtlpevgfKFGRWLDLV 157
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 57-145 2.29e-13

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 63.12  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940    57 FFVAKVGDKIVGFIVCDKDWFSkyegrivGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKNYGAMNL 135
Cdd:TIGR01575  33 YLLARIGGKVVGYAGVQIVLDE-------AHILNIAVKPEYQGQGIGRALLRELIDEAKGRGvNEIFLEVRVSNIAAQAL 105

                          90
                  ....*....|
gi 60593940   136 YEKFGFKKVG 145
Cdd:TIGR01575 106 YKKLGFNEIA 115
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 57-124 7.60e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 51.89  E-value: 7.60e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 60593940  57 FFVAKVGDKIVGFIVCDKDWFSKYEGRIvgaiHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELW 124
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGSGGDTAYI----GDLAVLPEYRGKGIGSALLEAAEEEARERGaKRLRLE 65
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 80-144 5.38e-06

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 43.76  E-value: 5.38e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 60593940   80 YEGRIVG-AIHEFV----------VDKKFQGKGIGRKLLITCLDFLGKyNDTIELW--VGEKNYGAMNLYEKFGFKKV 144
Cdd:PRK09491  47 VNGQMAAfAITQVVldeatlfniaVDPDYQRQGLGRALLEHLIDELEK-RGVATLWleVRASNAAAIALYESLGFNEV 123
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 40-141 8.68e-20

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 79.10  E-value: 8.68e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940    40 DYARNYIKWCWKKASDGFFVAKVGDKIVGFIVCDKDWfskyEGRIVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN- 118
Cdd:pfam00583  18 DEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIID----DEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGc 93

                          90       100
                  ....*....|....*....|...
gi 60593940   119 DTIELWVGEKNYGAMNLYEKFGF 141
Cdd:pfam00583  94 ERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
57-154 4.04e-17

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 73.49  E-value: 4.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  57 FFVAKVGDKIVGFIVCDkdWFSKYEGRIVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKNYGAMNL 135
Cdd:COG1247  54 VLVAEEDGEVVGFASLG--PFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARGyRRLVAVVLADNEASIAL 131

                        90       100
                ....*....|....*....|....*.
gi 60593940 136 YEKFGFKKVG-------KSGIWVRMI 154
Cdd:COG1247 132 YEKLGFEEVGtlpevgfKFGRWLDLV 157
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 68-145 3.73e-15

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.60  E-value: 3.73e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 60593940  68 GFIVCDKDWFSKYegrivGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKNYGAMNLYEKFGFKKVG 145
Cdd:COG0456   1 GFALLGLVDGGDE-----AEIEDLAVDPEYRGRGIGRALLEAALERARERGaRRLRLEVREDNEAAIALYEKLGFEEVG 74
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
53-150 7.59e-15

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 67.03  E-value: 7.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  53 ASDGFFVAKVGDKIVGFIVCDKDWFSKYEGriVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKNYG 131
Cdd:COG3153  37 AAGLSLVAEDDGEIVGHVALSPVDIDGEGP--ALLLGPLAVDPEYRGQGIGRALMRAALEAARERGaRAVVLLGDPSLLP 114

                        90
                ....*....|....*....
gi 60593940 132 amnLYEKFGFKKVGKSGIW 150
Cdd:COG3153 115 ---FYERFGFRPAGELGLT 130
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 53-159 2.03e-14

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 65.85  E-value: 2.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  53 ASDGFFVAKVGDKIVGFIvcdkdWFSKYEGRiVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKNYG 131
Cdd:COG0454  32 AGAEFIAVDDKGEPIGFA-----GLRRLDDK-VLELKRLYVLPEYRGKGIGKALLEALLEWARERGcTALELDTLDGNPA 105

                        90       100
                ....*....|....*....|....*...
gi 60593940 132 AMNLYEKFGFKKVGKSGIWVRMIKRQNL 159
Cdd:COG0454 106 AIRFYERLGFKEIERYVAYVGGEFEKEL 133
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 57-143 4.85e-14

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 63.63  E-value: 4.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940    57 FFVAKVGDKIVGFIVCDKDWFSKYEGRIvgaihEFVVDKKFQGKGIGRKLLITCLDFLGKYNdtIELWVGEKNYGAMNLY 136
Cdd:pfam13508   5 FFVAEDDGKIVGFAALLPLDDEGALAEL-----RLAVHPEYRGQGIGRALLEAAEAAAKEGG--IKLLELETTNRAAAFY 77


                  ....*..
gi 60593940   137 EKFGFKK 143
Cdd:pfam13508  78 EKLGFEE 84
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 57-145 2.29e-13

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 63.12  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940    57 FFVAKVGDKIVGFIVCDKDWFSkyegrivGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKNYGAMNL 135
Cdd:TIGR01575  33 YLLARIGGKVVGYAGVQIVLDE-------AHILNIAVKPEYQGQGIGRALLRELIDEAKGRGvNEIFLEVRVSNIAAQAL 105

                          90
                  ....*....|
gi 60593940   136 YEKFGFKKVG 145
Cdd:TIGR01575 106 YKKLGFNEIA 115
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 57-156 2.40e-13

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 62.67  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940    57 FFVAKVGDKIVGFIVCDKDWFskyegrivgaIHEFVVDKKFQGKGIGRKLLITCLDFLGKYND-TIELWVGEKNYgAMNL 135
Cdd:pfam13673  33 FFVAFEGGQIVGVIALRDRGH----------ISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIkLSELTVNASPY-AVPF 101

                          90       100
                  ....*....|....*....|....*.
gi 60593940   136 YEKFGFKKVG----KSGI-WVRMIKR 156
Cdd:pfam13673 102 YEKLGFRATGpeqeFNGIrFVPMEKE 127
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 57-147 1.20e-12

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 61.16  E-value: 1.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  57 FFVAKVGDKIVGFIVCDKDWfskyEGriVGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELWVGEKnygAMNL 135
Cdd:COG1246  30 FWVAEEDGEIVGCAALHPLD----ED--LAELRSLAVHPDYRGRGIGRRLLEALLAEARELGlKRLFLLTTSA---AIHF 100

                        90
                ....*....|..
gi 60593940 136 YEKFGFKKVGKS 147
Cdd:COG1246 101 YEKLGFEEIDKE 112
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 57-124 7.60e-10

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 51.89  E-value: 7.60e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 60593940  57 FFVAKVGDKIVGFIVCDKDWFSKYEGRIvgaiHEFVVDKKFQGKGIGRKLLITCLDFLGKYN-DTIELW 124
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGSGGDTAYI----GDLAVLPEYRGKGIGSALLEAAEEEARERGaKRLRLE 65
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 39-145 7.13e-09

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 51.92  E-value: 7.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  39 RDYARNYIKWC---WKKASDGFFVA--KVGDKIVGFI-VCDKDWFSKyegriVGAIHeFVVDKKFQGKGIGRKLLITCLD 112
Cdd:COG1670  41 LEEARAWLERLladWADGGALPFAIedKEDGELIGVVgLYDIDRANR-----SAEIG-YWLAPAYWGKGYATEALRALLD 114

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 60593940 113 F----LGKynDTIELWVGEKNYGAMNLYEKFGFKKVG 145
Cdd:COG1670 115 YafeeLGL--HRVEAEVDPDNTASIRVLEKLGFRLEG 149
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
58-156 3.77e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 49.41  E-value: 3.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  58 FVAKVGDKIVGFivcdkdwfskyeGRI------VGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYNDTiELWVGEKNYg 131
Cdd:COG2153  37 LLAYDDGELVAT------------ARLlppgdgEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGAR-RIVLSAQAH- 102

                        90       100       110
                ....*....|....*....|....*....|
gi 60593940 132 AMNLYEKFGFKKVG----KSGIW-VRMIKR 156
Cdd:COG2153 103 AVGFYEKLGFVPVGeeflEAGIPhIDMRKP 132
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
85-151 2.29e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 43.36  E-value: 2.29e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 60593940  85 VGAIHEFVVDKKFQGKGIGRKLLIT-CLDFLGKYNDTIELWVGEKNYGAMNLYEKFGFKKVGKSGIWV 151
Cdd:COG3393  15 VAEISGVYTHPEYRGRGLASALVAAlAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATVL 82
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 80-144 5.38e-06

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 43.76  E-value: 5.38e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 60593940   80 YEGRIVG-AIHEFV----------VDKKFQGKGIGRKLLITCLDFLGKyNDTIELW--VGEKNYGAMNLYEKFGFKKV 144
Cdd:PRK09491  47 VNGQMAAfAITQVVldeatlfniaVDPDYQRQGLGRALLEHLIDELEK-RGVATLWleVRASNAAAIALYESLGFNEV 123
PRK10562 PRK10562
putative acetyltransferase; Provisional
 39-146 1.61e-04

putative acetyltransferase; Provisional


Pssm-ID: 236715 [Multi-domain]  Cd Length: 145  Bit Score: 39.67  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940   39 RD-YARNYIKWCWKKASdgffvakvgdKIVGFIvcdkdwfSKYEGRIVGAIhefVVDKKFQGKGIGRKLLitclDFLGKY 117
Cdd:PRK10562  41 RDvYLPAAQTWVWEEDG----------KLLGFV-------SVLEGRFVGAL---FVAPKAVRRGIGKALM----QHVQQR 96

                         90       100
                 ....*....|....*....|....*....
gi 60593940  118 NDTIELWVGEKNYGAMNLYEKFGFKKVGK 146
Cdd:PRK10562  97 YPHLSLEVYQKNQRAVNFYHAQGFRIVDS 125
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 85-143 3.11e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 37.69  E-value: 3.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 60593940    85 VGAIHEFVVDKKFQGKGIGRKLLITCLDFLGKYNDTIELWVGEKNYGAMNLYEKFGFKK 143
Cdd:pfam08445  21 GGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKLGFRK 79
PRK07757 PRK07757
N-acetyltransferase;
57-112 3.45e-04

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 38.64  E-value: 3.45e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 60593940   57 FFVAKVGDKIVGFivcdkdwfskyegrivGAIHEF----------VVDKKFQGKGIGRKLLITCLD 112
Cdd:PRK07757  43 FYVAEEEGEIVGC----------------CALHILwedlaeirslAVSEDYRGQGIGRMLVEACLE 92
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
54-146 4.30e-04

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 38.76  E-value: 4.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940  54 SDGFFVAKVGDKIVGFIVC-----DKD-----WFSK------YEGRIVgaihefvVDKKFQGKGIGRKL----------- 106
Cdd:COG3818  44 AAYARVAEVDGEVAGFLLAfgpgaDYDspnyrWFAErydnflYIDRIV-------VAPSARGRGLGRALyadvfsyarar 116

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 60593940 107 ---LITCLDFLGKYNDtielwvgeknyGAMNLYEKFGFKKVGK 146
Cdd:COG3818 117 gvpRVTCEVNLEPPNP-----------GSLAFHARLGFREVGQ 148
COG5628 COG5628
Predicted acetyltransferase [General function prediction only];
58-105 1.15e-03

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 444356  Cd Length: 163  Bit Score: 37.22  E-value: 1.15e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 60593940  58 FVAKVGDKIVGFIVCDK--DWFSKYEgrivgaIHEFVVDKKFQGKGIGRK 105
Cdd:COG5628  58 YLIYVDGEPAGFALVRRlpFLESDYE------IAEFFVLRKYRRKGIGKR 101
PRK03624 PRK03624
putative acetyltransferase; Provisional
 57-141 5.91e-03

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 35.29  E-value: 5.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940   57 FFVAKVGDKIVGFIVcdkdwfSKYEG-RivGAIHEFVVDKKFQGKGIGRKLLITCLDFL-GKYNDTIELWVGEKNYGAMN 134
Cdd:PRK03624  47 FLVAEVGGEVVGTVM------GGYDGhR--GWAYYLAVHPDFRGRGIGRALVARLEKKLiARGCPKINLQVREDNDAVLG 118


                 ....*..
gi 60593940  135 LYEKFGF 141
Cdd:PRK03624 119 FYEALGY 125
PTZ00330 PTZ00330
acetyltransferase; Provisional
 82-143 9.15e-03

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 34.82  E-value: 9.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60593940   82 GRIVGAIHEFVVDKKFQGKGIGRKLLitcldflgkyNDTIELWVGEKNY--------GAMNLYEKFGFKK 143
Cdd:PTZ00330  79 GKCVGHIEDVVVDPSYRGQGLGRALI----------SDLCEIARSSGCYkvildcteDMVAFYKKLGFRA 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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