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Conserved domains on  [gi|602652336|ref|XP_007432541|]
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decorin [Python bivittatus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183199)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-299 2.48e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  79 TLLDLQNNKITEIKDgDFKNLKDLHALILVNNKISKIsPGAFSPLKKLERLYLSKNNLKELPENMP--KSLQELRAHEND 156
Cdd:COG4886  116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 157 IVKLrKAVFTGLNNVIVIELGTNPLKSsgiENGAFQGMKKLSYIRISDTNITTIP--KGLPvSLTELHLDGNKITKLeaD 234
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDL--P 266

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 602652336 235 SLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLAKVPAGLGEHKYIQVIYLHNNKI 299
Cdd:COG4886  267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRRNT smart00013
Leucine rich repeat N-terminal domain;
49-80 1.67e-13

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 63.88  E-value: 1.67e-13
                           10        20        30
                   ....*....|....*....|....*....|..
gi 602652336    49 CPFRCQCHLRVVQCSDLGLKEVPKDLPPDTTL 80
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-299 2.48e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  79 TLLDLQNNKITEIKDgDFKNLKDLHALILVNNKISKIsPGAFSPLKKLERLYLSKNNLKELPENMP--KSLQELRAHEND 156
Cdd:COG4886  116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 157 IVKLrKAVFTGLNNVIVIELGTNPLKSsgiENGAFQGMKKLSYIRISDTNITTIP--KGLPvSLTELHLDGNKITKLeaD 234
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDL--P 266

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 602652336 235 SLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLAKVPAGLGEHKYIQVIYLHNNKI 299
Cdd:COG4886  267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-267 2.74e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 2.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  50 PFRCQCHLRVVQCSDLGLKEVPKDLPPDTTLLDLQNNKITEIKDgdfKNLKDLHALILVNNKISKIsPGAFSplKKLERL 129
Cdd:PRK15370 215 PENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCL-PENLP--EELRYL 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 130 YLSKNNLKELPENMPKSLQELRAHENDIVKLRKAVFTGLNnviVIELGTNPLKSsgIENGAFQGMKKLSyirISDTNITT 209
Cdd:PRK15370 289 SVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTS--LPASLPPELQVLD---VSKNQITV 360

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 602652336 210 IPKGLPVSLTELHLDGNKITKLEadslSDLP-NLAKLGLSYNHIASVDNGslarVPHLR 267
Cdd:PRK15370 361 LPETLPPTITTLDVSRNALTNLP----ENLPaALQIMQASRNNLVRLPES----LPHFR 411
LRRNT smart00013
Leucine rich repeat N-terminal domain;
49-80 1.67e-13

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 63.88  E-value: 1.67e-13
                           10        20        30
                   ....*....|....*....|....*....|..
gi 602652336    49 CPFRCQCHLRVVQCSDLGLKEVPKDLPPDTTL 80
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-280 1.20e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  79 TLLDLQNNKITEIkdGDFKNLKDLHALILVNNKISKISpgAFSPLKKLERLYLSKNNLKELpENmpksLQELRAHEndiv 158
Cdd:cd21340    5 THLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-EN----LENLVNLK---- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 159 KLrkavFTGLNNVIVIElgtnplkssGIENgafqgMKKLSYIRISDTNIttiPKGLPV------------SLTELHLDGN 226
Cdd:cd21340   72 KL----YLGGNRISVVE---------GLEN-----LTNLEELHIENQRL---PPGEKLtfdprslaalsnSLRVLNISGN 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 602652336 227 KITKLEadSLSDLPNLAKLGLSYNHIASVDN--GSLARVPHLRELHLDNNDLAKVP 280
Cdd:cd21340  131 NIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
79-136 2.76e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 2.76e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 602652336   79 TLLDLQNNKITEIKDGDFKNLKDLHALILVNNKISKISPGAFSPLKKLERLYLSKNNL 136
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 49-75 6.21e-11

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 56.48  E-value: 6.21e-11
                          10        20
                  ....*....|....*....|....*..
gi 602652336   49 CPFRCQCHLRVVQCSDLGLKEVPKDLP 75
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-299 2.48e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.01  E-value: 2.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  79 TLLDLQNNKITEIKDgDFKNLKDLHALILVNNKISKIsPGAFSPLKKLERLYLSKNNLKELPENMP--KSLQELRAHEND 156
Cdd:COG4886  116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 157 IVKLrKAVFTGLNNVIVIELGTNPLKSsgiENGAFQGMKKLSYIRISDTNITTIP--KGLPvSLTELHLDGNKITKLeaD 234
Cdd:COG4886  194 ITDL-PEPLGNLTNLEELDLSGNQLTD---LPEPLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLSNNQLTDL--P 266

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 602652336 235 SLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLAKVPAGLGEHKYIQVIYLHNNKI 299
Cdd:COG4886  267 PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-305 9.93e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 9.93e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  83 LQNNKITEIKDGDFKNLKDLHALILVNNKISKISPGAFSPLKKLERLYLSKNNLKELPENMPKSLQELRAHENDIVKLRK 162
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 163 AVFTGLNNVIVIELGTNPLKSSGIENGAFQGMKKLSYIRISDTNITTIPKGLP--VSLTELHLDGNKITKLEaDSLSDLP 240
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLT 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 602652336 241 NLAKLGLSYNHIASVDNgSLARVPHLRELHLDNNDLAKVPAGLGEHKYIQVIYLHNNKIAAIGPN 305
Cdd:COG4886  160 NLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEP 223
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
78-302 1.57e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 1.57e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  78 TTLLDLQNNKITEIKDGDFKNLKDLHALILVNNKiskispgAFSPLKKLERLYLSKNNLKELPEnmpkslqelrahendi 157
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE---------------- 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 158 vklrkavftglnnvivielgtnplkssgiengAFQGMKKLSYIRISDTNITTIPKGLP--VSLTELHLDGNKITKLeADS 235
Cdd:COG4886  131 --------------------------------ELANLTNLKELDLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDL-PEE 177

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 602652336 236 LSDLPNLAKLGLSYNHIASVDNgSLARVPHLRELHLDNNDLAKVPAGLGEHKYIQVIYLHNNKIAAI 302
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-267 2.74e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 2.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  50 PFRCQCHLRVVQCSDLGLKEVPKDLPPDTTLLDLQNNKITEIKDgdfKNLKDLHALILVNNKISKIsPGAFSplKKLERL 129
Cdd:PRK15370 215 PENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPE---RLPSALQSLDLFHNKISCL-PENLP--EELRYL 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 130 YLSKNNLKELPENMPKSLQELRAHENDIVKLRKAVFTGLNnviVIELGTNPLKSsgIENGAFQGMKKLSyirISDTNITT 209
Cdd:PRK15370 289 SVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTS--LPASLPPELQVLD---VSKNQITV 360

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 602652336 210 IPKGLPVSLTELHLDGNKITKLEadslSDLP-NLAKLGLSYNHIASVDNGslarVPHLR 267
Cdd:PRK15370 361 LPETLPPTITTLDVSRNALTNLP----ENLPaALQIMQASRNNLVRLPES----LPHFR 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
65-293 3.08e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.96  E-value: 3.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  65 LGLKEVPKDLPPDTTLLDLQNNKITEIKDgdfknlkDLHALIlvnnkiskispgafsplkklERLYLSKNNLKELPENMP 144
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPE-------NLQGNI--------------------KTLYANSNQLTSIPATLP 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 145 KSLQELRAHENDIVKLRKAVFTGLNNVIVIELGTNPLKSSGIEngafqgmkKLSYIRISDTNITTIPKGLPVSLTELHLD 224
Cdd:PRK15370 241 DTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLPE--------ELRYLSVYDNSIRTLPAHLPSGITHLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 225 GNKIT-----------KLEAD--SLSDL-----PNLAKLGLSYNHIaSVDNGSLArvPHLRELHLDNNDLAKVPAGL-GE 285
Cdd:PRK15370 313 SNSLTalpetlppglkTLEAGenALTSLpaslpPELQVLDVSKNQI-TVLPETLP--PTITTLDVSRNALTNLPENLpAA 389


                 ....*...
gi 602652336 286 HKYIQVIY 293
Cdd:PRK15370 390 LQIMQASR 397
LRRNT smart00013
Leucine rich repeat N-terminal domain;
49-80 1.67e-13

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 63.88  E-value: 1.67e-13
                           10        20        30
                   ....*....|....*....|....*....|..
gi 602652336    49 CPFRCQCHLRVVQCSDLGLKEVPKDLPPDTTL 80
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-290 2.62e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 2.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  56 HLRVVQCSDLGLKEVPKDLPPDTTL--LDLQNNKITEIKDgDFKNLKDLHALILVNNKISKIsPGAFSPLKKLERLYLSK 133
Cdd:COG4886  160 NLKSLDLSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSN 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 134 NNLKELPE--NMPKsLQELRAHENDIVKLRKAvfTGLNNVIVIELGTNPLKSSGIEN-GAFQGMKKLSYIRISDTNITTI 210
Cdd:COG4886  238 NQLTDLPElgNLTN-LEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKElELLLGLNSLLLLLLLLNLLELL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 211 PKGLPVSLTELHLDGNKITKLEADSLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLAKVPAGLGEHKYIQ 290
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 79-280 1.20e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  79 TLLDLQNNKITEIkdGDFKNLKDLHALILVNNKISKISpgAFSPLKKLERLYLSKNNLKELpENmpksLQELRAHEndiv 158
Cdd:cd21340    5 THLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-EN----LENLVNLK---- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 159 KLrkavFTGLNNVIVIElgtnplkssGIENgafqgMKKLSYIRISDTNIttiPKGLPV------------SLTELHLDGN 226
Cdd:cd21340   72 KL----YLGGNRISVVE---------GLEN-----LTNLEELHIENQRL---PPGEKLtfdprslaalsnSLRVLNISGN 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 602652336 227 KITKLEadSLSDLPNLAKLGLSYNHIASVDN--GSLARVPHLRELHLDNNDLAKVP 280
Cdd:cd21340  131 NIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
79-136 2.76e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 2.76e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 602652336   79 TLLDLQNNKITEIKDGDFKNLKDLHALILVNNKISKISPGAFSPLKKLERLYLSKNNL 136
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
217-276 3.02e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 3.02e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  217 SLTELHLDGNKITKLEADSLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDL 276
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 49-75 6.21e-11

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 56.48  E-value: 6.21e-11
                          10        20
                  ....*....|....*....|....*..
gi 602652336   49 CPFRCQCHLRVVQCSDLGLKEVPKDLP 75
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-296 8.54e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.25  E-value: 8.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  69 EVPKDLPP--DTTLLDLQNNKIT-EIKDGdFKNLKDLHALILVNNKISKISPGAFSPLKKLERLYLSKNNLK-ELPENMP 144
Cdd:PLN00113 347 EIPKNLGKhnNLTVLDLSTNNLTgEIPEG-LCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFT 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 145 K---------SLQELRAHENDivklRKAVFTGLNnviVIELGTNPLkSSGIENgaFQGMKKLSYIRISDTNIT-TIPKGL 214
Cdd:PLN00113 426 KlplvyfldiSNNNLQGRINS----RKWDMPSLQ---MLSLARNKF-FGGLPD--SFGSKRLENLDLSRNQFSgAVPRKL 495

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 215 PV--SLTELHLDGNKITKLEADSLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLA-KVPAGLG-EHKYIQ 290
Cdd:PLN00113 496 GSlsELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGnVESLVQ 575


                 ....*.
gi 602652336 291 VIYLHN 296
Cdd:PLN00113 576 VNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-188 2.96e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.55  E-value: 2.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  57 LRVVQCSDLGLKEVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKDLHA------------------LILVNNKISkISPG 118
Cdd:PRK15370 285 LRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAgenaltslpaslppelqvLDVSKNQIT-VLPE 363

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 602652336 119 AFSPlkKLERLYLSKNNLKELPENMPKSLQELRAHENDIVKLRKAV--FTGLN---NVIVIElgTNPLKSSGIEN 188
Cdd:PRK15370 364 TLPP--TITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLphFRGEGpqpTRIIVE--YNPFSERTIQN 434
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 79-283 2.21e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.05  E-value: 2.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  79 TLLDLQNNKITEIKDGDFKNL---KDLHALILVNNKISKiSPGAF------SPLKKLERLYLSKNNL---------KELP 140
Cdd:cd00116   84 QELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGD-RGLRLlakglkDLPPALEKLVLGRNRLegascealaKALR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 141 ENmpKSLQELrahendivklrkavftglnnviviELGTNPLKSSGIENgAFQGMKKLSYIRISDTNITTI-PKGL----- 214
Cdd:cd00116  163 AN--RDLKEL------------------------NLANNGIGDAGIRA-LAEGLKANCNLEVLDLNNNGLtDEGAsalae 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 215 ----PVSLTELHLDGNKIT-----KLEADSLSDLPNLAKLGLSYNHIASVDNGSLARV----PHLRELHLDNNDLAKVPA 281
Cdd:cd00116  216 tlasLKSLEVLNLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFGEEGA 295


                 ..
gi 602652336 282 GL 283
Cdd:cd00116  296 QL 297
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 69-307 2.85e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 2.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  69 EVPKDLPPDTTL--LDLQNNKITEIKDGDFKNLKDLHALILVNNKIS-KISPGAFSpLKKLERLYLSKNNLK-ELPENMP 144
Cdd:PLN00113 227 EIPYEIGGLTSLnhLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSgEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 145 --KSLQELRAHENDIVKLRKAVFTGLNNVIVIELGTNPLkSSGIENGaFQGMKKLSYIRISDTNIT-TIPKGLPVS--LT 219
Cdd:PLN00113 306 qlQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPKN-LGKHNNLTVLDLSTNNLTgEIPEGLCSSgnLF 383

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 220 ELHLDGNKITKLEADSLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDL-AKVPAGLGEHKYIQVIYLHNNK 298
Cdd:PLN00113 384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqGRINSRKWDMPSLQMLSLARNK 463


                 ....*....
gi 602652336 299 IAAIGPNDF 307
Cdd:PLN00113 464 FFGGLPDSF 472
LRR_8 pfam13855
Leucine rich repeat;
102-157 3.31e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 3.31e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 602652336  102 LHALILVNNKISKISPGAFSPLKKLERLYLSKNNLKELPENM---PKSLQELRAHENDI 157
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-341 3.71e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 3.71e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  70 VPKDLPPDTTLLDLQNNKIT-EIKD--GDFKNLK--DLHALILVnnkiSKIsPGAFSPLKKLERLYLSKNnlkELPENMP 144
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSgEIPNdiGSFSSLKvlDLGGNVLV----GKI-PNSLTNLTSLEFLTLASN---QLVGQIP 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 145 KSLQELRAhendivklRKAVFTGLNNV---IVIELG---------------TNPLKSSgiengaFQGMKKLSYIRISDTN 206
Cdd:PLN00113 206 RELGQMKS--------LKWIYLGYNNLsgeIPYEIGgltslnhldlvynnlTGPIPSS------LGNLKNLQYLFLYQNK 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 207 IT-TIPKGL--PVSLTELHLDGNKITKLEADSLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLA-KVPAG 282
Cdd:PLN00113 272 LSgPIPPSIfsLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKN 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 602652336 283 LGEHKYIQVIYLHNNKIAAIGPNDFCPLGYNSKkasysgVSLFSNPVQfWEIQPSAFRC 341
Cdd:PLN00113 352 LGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFK------LILFSNSLE-GEIPKSLGAC 403
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 61-252 5.23e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.94  E-value: 5.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  61 QCSDLGLKEVPKDLPPDTTL--LDLQNNKITE------IKDGdfKNLKDLHALILVNNKISKISPGAFSPL----KKLER 128
Cdd:COG5238  191 QIGDEGIEELAEALTQNTTVttLWLKRNPIGDegaeilAEAL--KGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVET 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 129 LYLSKNNLKE-----LPENM--PKSLQELRAHENDI-----VKLRKavftGL-NNVIVIELGtnpLKSSGIENgafQGMK 195
Cdd:COG5238  269 LYLSGNQIGAegaiaLAKALqgNTTLTSLDLSVNRIgdegaIALAE----GLqGNKTLHTLN---LAYNGIGA---QGAI 338

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 602652336 196 KLSYIRISDTNITTI------------------PKGLPvSLTELHLDGNKITKLEADSLSDL---PNLAKLGLSYNHI 252
Cdd:COG5238  339 ALAKALQENTTLHSLdlsdnqigdegaialakyLEGNT-TLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
184-252 1.49e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.49e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 602652336  184 SGIENGAFQGMKklsyirisdtnittipkglpvSLTELHLDGNKITKLEADSLSDLPNLAKLGLSYNHI 252
Cdd:pfam13855  14 TSLDDGAFKGLS---------------------NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
81-150 2.41e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.29  E-value: 2.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 602652336   81 LDLQNNKITEIkDGdFKNLKDLHALILVNNKISKISPGAFSPLKKLERLYLSKNNLKELPENMP----KSLQEL 150
Cdd:pfam14580  47 IDFSDNEIRKL-DG-FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLDPlaslKKLTFL 118
LRR_8 pfam13855
Leucine rich repeat;
125-207 6.31e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 6.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  125 KLERLYLSKNNlkelpenmpkslqelrahendIVKLRKAVFTGLNNVIVIELGTNPLKSsgIENGAFQGMKKLSYIRISD 204
Cdd:pfam13855   2 NLRSLDLSNNR---------------------LTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 602652336  205 TNI 207
Cdd:pfam13855  59 NRL 61
LRR_8 pfam13855
Leucine rich repeat;
240-299 6.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 6.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 602652336  240 PNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLAKVPAGLGEH-KYIQVIYLHNNKI 299
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 53-236 2.37e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336  53 CQCHLRVVQCSDLGL-----KEVPKDLPPDTTL--LDLQNNKITEikDG------DFKNLKDLHALILVNNKI----SKI 115
Cdd:cd00116  135 LPPALEKLVLGRNRLegascEALAKALRANRDLkeLNLANNGIGD--AGiralaeGLKANCNLEVLDLNNNGLtdegASA 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602652336 116 SPGAFSPLKKLERLYLSKNNLKELPenmpkslqelrahendIVKLRKAVFTGLNNVIVIELGTNPLKSSGiengafqGMK 195
Cdd:cd00116  213 LAETLASLKSLEVLNLGDNNLTDAG----------------AAALASALLSPNISLLTLSLSCNDITDDG-------AKD 269

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 602652336 196 KLSYIRISdtnittipkglpVSLTELHLDGNKITK----LEADSL 236
Cdd:cd00116  270 LAEVLAEK------------ESLLELDLRGNKFGEegaqLLAESL 302
PLN03150 PLN03150
hypothetical protein; Provisional
 218-284 2.73e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.41  E-value: 2.73e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 602652336 218 LTELHLDGNKITKLEADSLSDLPNLAKLGLSYNHIASVDNGSLARVPHLRELHLDNNDLA-KVPAGLG 284
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
264-310 5.90e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 5.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 602652336  264 PHLRELHLDNNDLAKVPAGLGEH-KYIQVIYLHNNKIAAIGPNDFCPL 310
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAFSGL 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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