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Conserved domains on  [gi|60223051|ref|NP_001012481|]
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adenylate kinase isoenzyme 6 [Rattus norvegicus]

Protein Classification

adenylate kinase family protein( domain architecture ID 1904751)

adenylate kinase family protein such as adenylate kinase isoenzyme 6 that has ATPase activity and is a broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0005524|GO:0016887|GO:0050145
SCOP:  4004025

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Fap7 super family cl42788
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
6-144 1.93e-38

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


The actual alignment was detected with superfamily member COG1936:

Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 129.17  E-value: 1.93e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGHLYDGYDEEYGCPILDEDRVVDELEPqMTEGGVIVDYHGCDFFP 85
Cdd:COG1936   3 IAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVD 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051  86 -ERwfhiVFVLRTDNGILYKRLETRGYHEKKLQDNIQCEIFQVLYEEAMASYKEEIVHQL 144
Cdd:COG1936  82 vDR----VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEI 137
 
Name Accession Description Interval E-value
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
6-144 1.93e-38

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 129.17  E-value: 1.93e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGHLYDGYDEEYGCPILDEDRVVDELEPqMTEGGVIVDYHGCDFFP 85
Cdd:COG1936   3 IAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVD 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051  86 -ERwfhiVFVLRTDNGILYKRLETRGYHEKKLQDNIQCEIFQVLYEEAMASYKEEIVHQL 144
Cdd:COG1936  82 vDR----VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEI 137
AAA_18 pfam13238
AAA domain;
6-126 8.58e-35

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 118.30  E-value: 8.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051     6 ILLTGTPGVGKTTLGKELASRSGLkYVNVGDLAREGHLYDGYDEEY-GCPILDED---RVVDELE--PQMTEGG-VIVDY 78
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETrESKRLDEDkldRLLDLLEenAALEEGGnLIIDG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 60223051    79 HGCDFFPERWFHIVFV-LRTDNGILYKRLETRGYHEKKLQDNIQCEIFQ 126
Cdd:pfam13238  80 HLAELEPERAKDLVGIvLRASPEELLERLEKRGYEEAKIKENEEAEILG 128
PRK03839 PRK03839
putative kinase; Provisional
 6-133 3.62e-20

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 82.46  E-value: 3.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGHLYDGYDEEYGcpiLDEDRVVDELEPQMTEGGVIVDYHGCDFFP 85
Cdd:PRK03839   3 IAITGTPGVGKTTVSKLLAEKLGYEYVDLTEFALKKGIGEEKDDEME---IDFDKLAYFIEEEFKEKNVVLDGHLSHLLP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 60223051   86 ErwfHIVFVLRTDNGILYKRLETRGYHEKKLQDNIQCEIFQVLYEEAM 133
Cdd:PRK03839  80 V---DYVIVLRAHPKIIKERLKERGYSKKKILENVEAELVDVCLCEAL 124
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 5-138 2.87e-07

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 47.55  E-value: 2.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   5 NILLTGTPGVGKTTLGKELASRSGLKYVnvgDLareghlyDGYDEE-YGCPILD-------------EDRVVDELEPQM- 69
Cdd:cd00464   1 NIVLIGMMGAGKTTVGRLLAKALGLPFV---DL-------DELIEQrAGMSIPEifaeegeegfrelEREVLLLLLTKEn 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051  70 ----TEGGVIVDyhgcdffPE-RWF----HIVFVLRTDNGILYKRL---ETRGyhekKLQDNIQCEIFQvLYEEAMASYK 137
Cdd:cd00464  71 aviaTGGGAVLR-------EEnRRLllenGIVVWLDASPEELLERLardKTRP----LLQDEDPERLRE-LLEEREPLYR 138


                .
gi 60223051 138 E 138
Cdd:cd00464 139 E 139
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-34 1.96e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.97  E-value: 1.96e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 60223051      2 KLPNILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGV 33
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 6-40 2.21e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 36.70  E-value: 2.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGD-LARE 40
Cdd:NF033453  19 ILLVGPPGSGKTALLRELAAKRGAPVINVNLeLSRR 54
 
Name Accession Description Interval E-value
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
6-144 1.93e-38

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 129.17  E-value: 1.93e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGHLYDGYDEEYGCPILDEDRVVDELEPqMTEGGVIVDYHGCDFFP 85
Cdd:COG1936   3 IAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVD 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051  86 -ERwfhiVFVLRTDNGILYKRLETRGYHEKKLQDNIQCEIFQVLYEEAMASYKEEIVHQL 144
Cdd:COG1936  82 vDR----VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEI 137
AAA_18 pfam13238
AAA domain;
6-126 8.58e-35

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 118.30  E-value: 8.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051     6 ILLTGTPGVGKTTLGKELASRSGLkYVNVGDLAREGHLYDGYDEEY-GCPILDED---RVVDELE--PQMTEGG-VIVDY 78
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETrESKRLDEDkldRLLDLLEenAALEEGGnLIIDG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 60223051    79 HGCDFFPERWFHIVFV-LRTDNGILYKRLETRGYHEKKLQDNIQCEIFQ 126
Cdd:pfam13238  80 HLAELEPERAKDLVGIvLRASPEELLERLEKRGYEEAKIKENEEAEILG 128
PRK03839 PRK03839
putative kinase; Provisional
 6-133 3.62e-20

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 82.46  E-value: 3.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGHLYDGYDEEYGcpiLDEDRVVDELEPQMTEGGVIVDYHGCDFFP 85
Cdd:PRK03839   3 IAITGTPGVGKTTVSKLLAEKLGYEYVDLTEFALKKGIGEEKDDEME---IDFDKLAYFIEEEFKEKNVVLDGHLSHLLP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 60223051   86 ErwfHIVFVLRTDNGILYKRLETRGYHEKKLQDNIQCEIFQVLYEEAM 133
Cdd:PRK03839  80 V---DYVIVLRAHPKIIKERLKERGYSKKKILENVEAELVDVCLCEAL 124
aroK PRK00131
shikimate kinase; Reviewed
 1-138 9.74e-09

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 51.73  E-value: 9.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051    1 MKLPNILLTGTPGVGKTTLGKELASRSGLKYVNVgDLAREghlydgydEEYGCPILD-------------EDRVVDELeP 67
Cdd:PRK00131   2 LKGPNIVLIGFMGAGKSTIGRLLAKRLGYDFIDT-DHLIE--------ARAGKSIPEifeeegeaafrelEEEVLAEL-L 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   68 QMTE------GGVIVDyhgcdffPERW-----FHIVFVLRTDNGILYKRL---ETRGYhekkLQDNIQCEIFQVLYEEAM 133
Cdd:PRK00131  72 ARHNlvistgGGAVLR-------EENRallreRGTVVYLDASFEELLRRLrrdRNRPL----LQTNDPKEKLRDLYEERD 140


                 ....*
gi 60223051  134 ASYKE 138
Cdd:PRK00131 141 PLYEE 145
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 5-138 2.87e-07

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 47.55  E-value: 2.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   5 NILLTGTPGVGKTTLGKELASRSGLKYVnvgDLareghlyDGYDEE-YGCPILD-------------EDRVVDELEPQM- 69
Cdd:cd00464   1 NIVLIGMMGAGKTTVGRLLAKALGLPFV---DL-------DELIEQrAGMSIPEifaeegeegfrelEREVLLLLLTKEn 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051  70 ----TEGGVIVDyhgcdffPE-RWF----HIVFVLRTDNGILYKRL---ETRGyhekKLQDNIQCEIFQvLYEEAMASYK 137
Cdd:cd00464  71 aviaTGGGAVLR-------EEnRRLllenGIVVWLDASPEELLERLardKTRP----LLQDEDPERLRE-LLEEREPLYR 138


                .
gi 60223051 138 E 138
Cdd:cd00464 139 E 139
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 6-34 3.70e-06

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 44.12  E-value: 3.70e-06
                          10        20
                  ....*....|....*....|....*....
gi 60223051     6 ILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEI 29
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 5-114 4.72e-06

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 44.54  E-value: 4.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   5 NILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREghlydgydeeygcPILDEDRVVDELEPQMTEGGVIVD------- 77
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLRE-------------EIASGTELGKKAKEYIDSGKLVPDeivikll 67

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 60223051  78 ---------YHGC--DFFP------ERWFHI---------VFVLRTDNGILYKRLETRGYHEK 114
Cdd:cd01428  68 kerlkkpdcKKGFilDGFPrtvdqaEALDELldegikpdkVIELDVPDEVLIERILGRRICPV 130
AAA_17 pfam13207
AAA domain;
9-110 5.96e-06

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 43.77  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051     9 TGTPGVGKTTLGKELASRSGLKYVNVGDL----AREGHLYDGYDEeygcpILDEDRVVDELEPQM---------TEGGVI 75
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLlreeAKERGLVEDRDE-----MRKLPLEPQKELQKLaaeriaeeaGEGGVI 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 60223051    76 VDYHGC-----DFFP--ERWF-------HIVFVLRTDNGILYKRL--ETRG 110
Cdd:pfam13207  76 VDGHPRiktpaGYLPglPVEVlrelkpdAIILLEADPEEILERRLkdRTRG 126
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 2-109 8.80e-06

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 43.29  E-value: 8.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   2 KLPNILLTGTPGVGKTTLGKELASRSGLK-----YVNVGDLaREGHLYDGYDE--------------EYGCPILDEdrvV 62
Cdd:cd00009  18 PPKNLLLYGPPGTGKTTLARAIANELFRPgapflYLNASDL-LEGLVVAELFGhflvrllfelaekaKPGVLFIDE---I 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 60223051  63 DELEPQMTEGGVIVDYHGCDFFPERWFHIVFVLRTDNGI------LYKRLETR 109
Cdd:cd00009  94 DSLSRGAQNALLRVLETLNDLRIDRENVRVIGATNRPLLgdldraLYDRLDIR 146
PRK04182 PRK04182
cytidylate kinase; Provisional
 6-40 9.50e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 43.64  E-value: 9.50e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLARE 40
Cdd:PRK04182   3 ITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 5-40 4.78e-05

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 42.04  E-value: 4.78e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 60223051   5 NILLTGTPGVGKTTLGKELASRSGLKYVNVGDLARE 40
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRA 37
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 6-40 4.88e-05

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 41.86  E-value: 4.88e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLARE 40
Cdd:COG2074   9 ILIGGASGVGKSTIAAELARRLGIPRVISTDSIRE 43
PRK14530 PRK14530
adenylate kinase; Provisional
 1-54 6.60e-05

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 41.70  E-value: 6.60e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 60223051    1 MKLPNILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGHLYDGYD--EEYGCP 54
Cdd:PRK14530   1 MSQPRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANKQMDISDmdTEYDTP 56
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 5-41 7.63e-05

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 40.97  E-value: 7.63e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 60223051   5 NILLTGTPGVGKTTLGKELASRSGLKYV-----NVGDLAREG 41
Cdd:cd19512  24 NILFYGPPGTGKTLFAKKLALHSGMDYAimtggDVAPMGREG 65
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
6-110 8.34e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 40.67  E-value: 8.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNVgDLAREgHLYDGYDEEYGCPILDEDRVVDELEPQMTE---GG--VIVDyHG 80
Cdd:COG0645   2 ILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRK-RLFGAGLAPLERSPEATARTYARLLALAREllaAGrsVILD-AT 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 60223051  81 CDFFPER-WF----------HIVFVLRTDNGILYKRLETRG 110
Cdd:COG0645  79 FLRRAQReAFralaeeagapFVLIWLDAPEEVLRERLEARN 119
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 6-40 1.19e-04

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 40.94  E-value: 1.19e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLARE 40
Cdd:PTZ00088   9 IVLFGAPGVGKGTFAEILSKKENLKHINMGNILRE 43
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 1-42 1.22e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 40.62  E-value: 1.22e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 60223051   1 MKLPNILLTGTPGVGKTTLGKELASRSGLKYVN--VGDLARE----GH 42
Cdd:cd19500  35 MKGPILCLVGPPGVGKTSLGKSIARALGRKFVRisLGGVRDEaeirGH 82
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 6-55 1.27e-04

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 40.50  E-value: 1.27e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNVgDLAREghlydgydEEYGCPI 55
Cdd:COG0703   1 IVLIGMMGAGKSTVGRLLAKRLGLPFVDT-DAEIE--------ERAGMSI 41
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 6-47 1.65e-04

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 41.05  E-value: 1.65e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNVgDLAReghLYDGY 47
Cdd:COG0464 194 LLLYGPPGTGKTLLARALAGELGLPLIEV-DLSD---LVSKY 231
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 4-34 1.97e-04

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 39.57  E-value: 1.97e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 60223051   4 PNILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:cd19481  27 KGILLYGPPGTGKTLLAKALAGELGLPLIVV 57
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 6-39 2.16e-04

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 39.54  E-value: 2.16e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNvGDLAR 39
Cdd:cd02021   2 IVVMGVSGSGKSTVGKALAERLGAPFID-GDDLH 34
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 6-131 2.23e-04

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 39.71  E-value: 2.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNV----GDLAREGHLYDGY-DEEYGCPILDedrVVDELEPQMTEGGVIVDYHG 80
Cdd:COG4088   7 LILTGPPGSGKTTFAKALAQRLYAEGIAVallhSDDFRRFLVNESFpKETYEEVVED---VRTTTADNALDNGYSVIVDG 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 60223051  81 CDFFPE--RWFHIVFVLRTDNGILYKR--LET--RGYHEKKLQdnIQCEIFQVLYEE 131
Cdd:COG4088  84 TFYYRSwqRDFRNLAKHKAPIHIIYLKapLETalRRNRERGEP--IPERVIARMYRK 138
AAA_28 pfam13521
AAA domain;
6-32 3.92e-04

AAA domain;


Pssm-ID: 433278 [Multi-domain]  Cd Length: 164  Bit Score: 38.78  E-value: 3.92e-04
                          10        20
                  ....*....|....*....|....*..
gi 60223051     6 ILLTGTPGVGKTTLGKELASRSGLKYV 32
Cdd:pfam13521   2 IVITGGPSTGKTTLAEALAARFGYPVV 28
PRK10787 PRK10787
DNA-binding ATP-dependent protease La; Provisional
 1-32 6.39e-04

DNA-binding ATP-dependent protease La; Provisional


Pssm-ID: 182730 [Multi-domain]  Cd Length: 784  Bit Score: 39.54  E-value: 6.39e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 60223051    1 MKLPNILLTGTPGVGKTTLGKELASRSGLKYV 32
Cdd:PRK10787 347 IKGPILCLVGPPGVGKTSLGQSIAKATGRKYV 378
PRK04040 PRK04040
adenylate kinase; Provisional
 6-37 7.19e-04

adenylate kinase; Provisional


Pssm-ID: 235210  Cd Length: 188  Bit Score: 38.34  E-value: 7.19e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKY--VNVGDL 37
Cdd:PRK04040   5 VVVTGVPGVGKTTVLNKALEKLKEDYkiVNFGDV 38
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 6-31 8.42e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 38.61  E-value: 8.42e-04
                        10        20
                ....*....|....*....|....*.
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKY 31
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALARALGLPF 59
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 2-32 9.02e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 38.53  E-value: 9.02e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 60223051    2 KLPNILLTGTPGVGKTTLGKELASRSGLKYV 32
Cdd:PRK13342  35 RLSSMILWGPPGTGKTTLARIIAGATDAPFE 65
PRK14021 PRK14021
bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional
 1-66 1.09e-03

bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional


Pssm-ID: 184458 [Multi-domain]  Cd Length: 542  Bit Score: 38.69  E-value: 1.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 60223051    1 MKLPNILLTGTPGVGKTTLGKELASRSGLKYVNVGD-LARE-GHLYDGYDEEYGCPI---LDEDRVVDELE 66
Cdd:PRK14021   4 TRRPQAVIIGMMGAGKTRVGKEVAQMMRLPFADADVeIEREiGMSIPSYFEEYGEPAfreVEADVVADMLE 74
PRK05541 PRK05541
adenylylsulfate kinase; Provisional
 6-50 1.28e-03

adenylylsulfate kinase; Provisional


Pssm-ID: 235498  Cd Length: 176  Bit Score: 37.73  E-value: 1.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNV----GDLARE--GHlyDGYDEE 50
Cdd:PRK05541  10 IWITGLAGSGKTTIAKALYERLKLKYSNViyldGDELREilGH--YGYDKQ 58
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 6-34 1.58e-03

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 37.26  E-value: 1.58e-03
                        10        20
                ....*....|....*....|....*....
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:cd19511  30 VLLYGPPGCGKTLLAKALASEAGLNFISV 58
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 6-34 1.71e-03

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 37.02  E-value: 1.71e-03
                        10        20
                ....*....|....*....|....*....
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:cd19520  38 VLLYGPPGCGKTMLAKATAKEAGARFINL 66
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 2-34 1.96e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 36.97  E-value: 1.96e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 60223051      2 KLPNILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGGGV 33
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 6-40 2.21e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 36.70  E-value: 2.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGD-LARE 40
Cdd:NF033453  19 ILLVGPPGSGKTALLRELAAKRGAPVINVNLeLSRR 54
AAA_3 pfam07726
ATPase family associated with various cellular activities (AAA); This Pfam entry includes some ...
 6-31 2.74e-03

ATPase family associated with various cellular activities (AAA); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 429622 [Multi-domain]  Cd Length: 131  Bit Score: 36.00  E-value: 2.74e-03
                          10        20
                  ....*....|....*....|....*.
gi 60223051     6 ILLTGTPGVGKTTLGKELASRSGLKY 31
Cdd:pfam07726   2 VLLEGVPGLAKTLLVRTLARSLGLDF 27
DPCK cd02022
Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of ...
 6-84 2.86e-03

Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis.


Pssm-ID: 238980  Cd Length: 179  Bit Score: 36.73  E-value: 2.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051   6 ILLTGTPGVGKTTLGKELasrsglkyvnvgdlareghlydgydEEYGCPILDEDRVV-DELEPQMTEGGVIVDYHGCDFF 84
Cdd:cd02022   2 IGLTGGIGSGKSTVAKLL-------------------------KELGIPVIDADKIAhEVYEPGGPALQAIVEAFGPDIL 56
44 PHA02544
clamp loader, small subunit; Provisional
 2-36 3.68e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 36.89  E-value: 3.68e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 60223051    2 KLPNILL-TGTPGVGKTTLGKELASRSGLKY--VNVGD 36
Cdd:PHA02544  41 RIPNMLLhSPSPGTGKTTVAKALCNEVGAEVlfVNGSD 78
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 2-32 4.10e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 36.96  E-value: 4.10e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 60223051   2 KLPNILLTGTPGVGKTTLGKELASRSGLKYV 32
Cdd:COG2256  48 RLSSMILWGPPGTGKTTLARLIANATDAEFV 78
PRK00625 PRK00625
shikimate kinase; Provisional
 5-114 4.68e-03

shikimate kinase; Provisional


Pssm-ID: 134335 [Multi-domain]  Cd Length: 173  Bit Score: 35.89  E-value: 4.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 60223051    5 NILLTGTPGVGKTTLGKELASRSGLKYVNVGDL----------AREGHLYDGYDEEYGCPIldEDRVVDEL--EPQMTE- 71
Cdd:PRK00625   2 QIFLCGLPTVGKTSFGKALAKFLSLPFFDTDDLivsnyhgalySSPKEIYQAYGEEGFCRE--EFLALTSLpvIPSIVAl 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 60223051   72 -GGVIVDYHGCDFFPERWFhIVFvLRTDNGILYKRLETRGYHEK 114
Cdd:PRK00625  80 gGGTLMIEPSYAHIRNRGL-LVL-LSLPIATIYQRLQKRGLPER 121
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 6-34 5.10e-03

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 36.52  E-value: 5.10e-03
                        10        20
                ....*....|....*....|....*....
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:COG1222 115 VLLYGPPGTGKTLLAKAVAGELGAPFIRV 143
PRK13695 PRK13695
NTPase;
5-30 5.11e-03

NTPase;


Pssm-ID: 237475  Cd Length: 174  Bit Score: 36.04  E-value: 5.11e-03
                         10        20
                 ....*....|....*....|....*....
gi 60223051    5 NILLTGTPGVGKTTLGK---ELASRSGLK 30
Cdd:PRK13695   2 KIGITGPPGVGKTTLVLkiaELLKEEGYK 30
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 6-34 5.69e-03

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 35.79  E-value: 5.69e-03
                        10        20
                ....*....|....*....|....*....
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:cd19509  35 ILLYGPPGTGKTLLARAVASESGSTFFSI 63
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 5-34 6.35e-03

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 35.48  E-value: 6.35e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 60223051   5 NILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:cd19526  29 GILLYGPPGCGKTLLASAIASECGLNFISV 58
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 6-34 6.73e-03

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 35.55  E-value: 6.73e-03
                        10        20
                ....*....|....*....|....*....
gi 60223051   6 ILLTGTPGVGKTTLGKELASRSGLKYVNV 34
Cdd:cd19529  30 ILLYGPPGTGKTLLAKAVATESNANFISV 58
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
5-40 6.82e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 35.91  E-value: 6.82e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 60223051   5 NILLTGTPGVGKT----TLGKELAsRSGLK--YVNVGDLARE 40
Cdd:COG1484 101 NLILLGPPGTGKThlaiALGHEAC-RAGYRvrFTTAPDLVNE 141
NTPase_1 pfam03266
NTPase; This domain is found across all species from bacteria to human, and the function was ...
 5-31 8.03e-03

NTPase; This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme. The sequence carries both a Walker A and Walker B motif which together are characteriztic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue.


Pssm-ID: 460869  Cd Length: 168  Bit Score: 35.29  E-value: 8.03e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 60223051     5 NILLTGTPGVGKTTLGK---ELASRSGLKY 31
Cdd:pfam03266   1 RIFITGPPGVGKTTLVLkvaELLKSSGVKV 30
THEP1 COG1618
Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];
4-35 8.28e-03

Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];


Pssm-ID: 441225 [Multi-domain]  Cd Length: 175  Bit Score: 35.26  E-value: 8.28e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 60223051   4 PNILLTGTPGVGKTTLGKELASRSGLKYVNVG 35
Cdd:COG1618   1 MKIFITGRPGVGKTTLLLKVVEELRDEGLRVG 32
PRK04220 PRK04220
2-phosphoglycerate kinase; Provisional
 6-40 9.34e-03

2-phosphoglycerate kinase; Provisional


Pssm-ID: 179793 [Multi-domain]  Cd Length: 301  Bit Score: 35.71  E-value: 9.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 60223051    6 ILLTGTPGVGKTTLGKELASRSGLKYVNVGDLARE 40
Cdd:PRK04220  95 ILIGGASGVGTSTIAFELASRLGIRSVIGTDSIRE 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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