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Conserved domains on  [gi|6005772|ref|NP_009154|]
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G-protein coupled receptor 176 isoform 1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606628)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
43-331 0e+00

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 528.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd15006   1 FTTTVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHCCWWIYTLLFCKVIKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGH 202
Cdd:cd15006  81 LHKVFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIYAMSTCTESWGYSLGH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPY 282
Cdd:cd15006 161 LVYVIIYNITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTPQNTISIPYVSQREAELHAMLLSMVLVFILCSVPY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  283 ATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15006 241 ATLVIYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRKCL 289
 
Name Accession Description Interval E-value
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
43-331 0e+00

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 528.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd15006   1 FTTTVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHCCWWIYTLLFCKVIKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGH 202
Cdd:cd15006  81 LHKVFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIYAMSTCTESWGYSLGH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPY 282
Cdd:cd15006 161 LVYVIIYNITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTPQNTISIPYVSQREAELHAMLLSMVLVFILCSVPY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  283 ATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15006 241 ATLVIYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRKCL 289
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
58-319 4.38e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 101.22  E-value: 4.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772     58 GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDII-LSTSPHccwWIYTMLFCKVVKFLHKVFCSVTILSFP 136
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGD---WPFGSALCKIVGALFVVNGYASILLLT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772    137 AIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVP--VFAVTNVADIYATSTCTEVWSNSLGHLVYVLVYnit 212
Cdd:pfam00001  78 AISIDRYLAIVHPLRYKRRRTPRRAKVLilVIWVLALLLSLPplLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLL--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772    213 tviVPVVVVFLFLILIrrALSASQkkkvIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYATLVVYQTVL 292
Cdd:pfam00001 155 ---ISVLGFLLPLLVI--LVCYTL----IIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLA 225
                         250       260       270
                  ....*....|....*....|....*....|
gi 6005772    293 N---VPDTSVFLLLTAVWLPKVSLLANPVL 319
Cdd:pfam00001 226 LdceLSRLLDKALSVTLWLAYVNSCLNPII 255
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-192 5.46e-11

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 64.03  E-value: 5.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772    45 TTVQVVIFIGSLLGNFMVLWSTCRTTVfKSVTNRFIKNLACSGICASLVcVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:PHA03087  44 IVVYSTIFFFGLVGNIIVIYVLTKTKI-KTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQ---WSFGEFACKIVSGLY 118
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASVPVFAVTNVADIYATSTC 192
Cdd:PHA03087 119 YIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIvsLVIWIISIIETTPILFVYTTKKDHETLIC 188
 
Name Accession Description Interval E-value
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
43-331 0e+00

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 528.29  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd15006   1 FTTTVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVCVPFDIVLSASPHCCWWIYTLLFCKVIKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGH 202
Cdd:cd15006  81 LHKVFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIYIWAHAVVASVPVFAVTNVTDIYAMSTCTESWGYSLGH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPY 282
Cdd:cd15006 161 LVYVIIYNITTVILPVAVVFLFMILIRRALSASQKKKVIIAALRTPQNTISIPYVSQREAELHAMLLSMVLVFILCSVPY 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  283 ATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15006 241 ATLVIYRTILNISDISVFLLLTAIWLPKVSLLANPLLFLTVNKSVRKCL 289
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
45-324 1.23e-40

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.44  E-value: 1.23e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd00637   2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGR---WWFGDALCKLLGFLQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGH 202
Cdd:cd00637  79 SVSLLASILTLTAISVDRYLAIVHPLryRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKkviiaaLRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPY 282
Cdd:cd00637 159 KAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRR------IRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPY 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6005772  283 ATLVVYQTVL-NVPDTSVFLLLTAVWLPKVSLLANPVLFLTVN 324
Cdd:cd00637 233 FILLLLDVFGpDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
43-329 3.70e-27

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 110.77  E-value: 3.70e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15203   2 ILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKN---WPFGSILCKLVPS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATST------CTEVW 196
Cdd:cd15203  79 LQGVSIFVSTLTLTAIAIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILpycgyfCTESW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVY---VLVynittvivpvvvvFLFLI----------LIRRALSASQKKKVIIAALRTPQNTIsipyASQREAE 263
Cdd:cd15203 159 PSSSSRLIYtisVLV-------------LQFVIplliisfcyfRISLKLRKRVKKKRGKRTLSSRRRRS----ELRRKRR 221
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  264 LHATLLSMVMVFILCSVPYATLVVYQTVLNVP----DTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15203 222 TNRLLIAMVVVFAVCWLPLNLFNLLRDFEPLPqidgRHFYLIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
49-331 1.79e-24

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 103.45  E-value: 1.79e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPhccWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd14993   8 VVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYR---PWVFGEVLCKAVPYLQGVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAVTNVADIYATS-------TCTEVWSNS 199
Cdd:cd14993  85 SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIivAIWVIAIIIMLPLLVVYELEEIISSEpgtitiyICTEDWPSP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGHLVYVLVynittvivpvvvVFLFLILI----------RRALSASQKKKVIIAALRTPQNTISIPYASQREAELhatLL 269
Cdd:cd14993 165 ELRKAYNVA------------LFVVLYVLplliisvaysLIGRRLWRRKPPGDRGSANSTSSRRILRSKKKVARM---LI 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  270 SMVMVFILCSVPYATLVVYqTVLNVPDTSVFLLLTAVWLPKVSLL------ANPVLFLTVNKSVRKCL 331
Cdd:cd14993 230 VVVVLFALSWLPYYVLSIL-LDFGPLSSEESDENFLLILPFAQLLgysnsaINPIIYCFMSKKFRRGF 296
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
58-319 4.38e-24

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 101.22  E-value: 4.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772     58 GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDII-LSTSPHccwWIYTMLFCKVVKFLHKVFCSVTILSFP 136
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGD---WPFGSALCKIVGALFVVNGYASILLLT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772    137 AIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVP--VFAVTNVADIYATSTCTEVWSNSLGHLVYVLVYnit 212
Cdd:pfam00001  78 AISIDRYLAIVHPLRYKRRRTPRRAKVLilVIWVLALLLSLPplLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLL--- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772    213 tviVPVVVVFLFLILIrrALSASQkkkvIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYATLVVYQTVL 292
Cdd:pfam00001 155 ---ISVLGFLLPLLVI--LVCYTL----IIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLA 225
                         250       260       270
                  ....*....|....*....|....*....|
gi 6005772    293 N---VPDTSVFLLLTAVWLPKVSLLANPVL 319
Cdd:pfam00001 226 LdceLSRLLDKALSVTLWLAYVNSCLNPII 255
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
44-281 9.09e-22

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 94.65  E-value: 9.09e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFL 123
Cdd:cd15001   2 VIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPT---WSLGAFLCKAVAYL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERKI--SDAKSRELVMYIWAHAVVASVPVFAVTNVADIY-----ATSTCTEVW 196
Cdd:cd15001  79 QLLSFICSVLTLTAISIERYYVILHPMKAKSfcTIGRARKVALLIWILSAILASPVLFGQGLVRYEsengvTVYHCQKAW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVYVlVYNittvivpvvvvFLFLILIrralsasqkkkviiaalrtPQNTISIPYASQREAELHATLLSMVMVFI 276
Cdd:cd15001 159 PSTLYSRLYV-VYL-----------AIVIFFI-------------------PLIVMTFAYARDTRKQVIKMLISVVVLFA 207

                ....*
gi 6005772  277 LCSVP 281
Cdd:cd15001 208 VCWGP 212
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
49-329 2.18e-21

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 94.23  E-value: 2.18e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPF----DIILStsphccwWIYTMLFCKVVKFLH 124
Cdd:cd15207   8 SLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFtlvdNILTG-------WPFGDVMCKLSPLVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYAT-----STCTEVWSNS 199
Cdd:cd15207  81 GVSVAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFrgqtvHICVEFWPSD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGHLVY-----VLVYnittvivpvvVVFLFLIL---IRRALSASQKKKViiAALRTPQNtiSIPYASQREAELHATLLSM 271
Cdd:cd15207 161 EYRKAYttslfVLCY----------VAPLLIIAvlyVRIGYRLWFKPVP--GGGSASRE--AQAAVSKKKVRVIKMLIVV 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6005772  272 VMVFILCSVPYATLVVYQTVLNVPDTSVFLLL-----TAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15207 227 VVLFALSWLPLHTVTMLDDFGNLSPNQREVLYvyiypIAHWLAYFNSCVNPIVYGYFNRNFRK 289
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
50-328 1.27e-20

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 92.18  E-value: 1.27e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15202   9 FIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNT---WIFGLFMCHFSNFAQYCSVH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVfAVTNVADIYATST------CTEVWSNS---- 199
Cdd:cd15202  86 VSAYTLTAIAVDRYQAIMHPLKPRISKTKAKFIIAVIWTLALAFALPH-AICSKLETFKYSEdivrslCLEDWPERadlf 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 ---LGHLVYVLVYnittvivpvvvvFLFLILIRRALSASQKKkviIAALRTPQNTISIPYASQREAELHAT--LLSMVMV 274
Cdd:cd15202 165 wkyYDLALFILQY------------FLPLLVISFAYARVGIK---LWASNMPGDATTERYFALRRKKKKVIkmLMVVVVL 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  275 FILCSVPYATLVV--YQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15202 230 FALCWLPFNIYVLllSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFR 285
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
49-196 1.40e-20

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 91.72  E-value: 1.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15394   9 LVVLVG-VVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRG--WVFGRFMCYFVFLMQPVTV 85
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADI--YATSTCTEVW 196
Cdd:cd15394  86 YVSVFTLTAIAVDRYYVTVYPLRRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFkgLDFSICEEFW 155
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
49-320 1.50e-20

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 92.07  E-value: 1.50e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15208   8 ILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTET---WFFGQVLCKIIPYLQTVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNV-------ADIYATSTCTEVWSNSLG 201
Cdd:cd15208  85 SVSVLTLSCIALDRWYAICHPLMFKSTAKRARVSILIIWIVSLLIMIPQAIVMECsrvvplaNKTILLTVCDERWSDSIY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 HLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRtPQNTISIPYASQREAELHA------TLLSMVMVF 275
Cdd:cd15208 165 QKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSSVVQR-KWNKPRKSAVAAEEKQLRSrrktakMLIVVVIMF 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  276 ILCSVPYATLVVYQTV----LNVPDTSVFLLLTAVWLPKVSLLANPVLF 320
Cdd:cd15208 244 AICYLPVHLLNILRYVfglfTVDRETIYAWFLFSHWLVYANSAINPIIY 292
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
49-331 3.94e-20

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 90.34  E-value: 3.94e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPhccWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd14969   8 SLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSG---RWSFGDPGCVIYGFAVTFLG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPL-ERKISDAKSRELVMYIWAHAVV-ASVPVFAVTNvadiYA----TSTCTEVW-SNSLG 201
Cdd:cd14969  85 LVSISTLAALAFERYLVIVRPLkAFRLSKRRALILIAFIWLYGLFwALPPLFGWSS----YVpeggGTSCSVDWySKDPN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 HLVYVLVYnittvivpvvVVFLFLI----------LIRRALSASQKkkviiaalRTPQNTISIPYASQREAELHATLLSM 271
Cdd:cd14969 161 SLSYIVSL----------FVFCFFLplaiiifcyyKIYRTLRKMSK--------RAARRKNSAITKRTKKAEKKVAKMVL 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  272 VMV--FILCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd14969 223 VMIvaFLIAWTPYAVVSLYVSFGGESTIPPLLATIPALFAKSSTIYNPIIYVFMNKQFRRAL 284
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
49-331 1.73e-18

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 85.38  E-value: 1.73e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15214   7 IIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRRE---WIFGVVWCNFSALLYLLIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASV-PVFAVTNVADIYATSTCTEVWSNSLGHLVY 205
Cdd:cd15214  84 SASMLTLGAIAIDRYYAVLYPMvyPMKITGNRAVLALVYIWLHSLIGCLpPLFGWSSLEFDRFKWMCVAAWHKEAGYTAF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  206 VLVYNITTVIVPVVVVFLFLILIRRalsASQKKKVIiaalrtpqntisipyasqreaelhaTLLSMVMVFILCSVPYATL 285
Cdd:cd15214 164 WQVWCALLPFVVMLVCYGFIFRVAR---ANQCKAFI-------------------------TILVVLGAFVTTWGPYMVV 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6005772  286 VVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15214 216 ISTEALWGKNSVSPQLETLATWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
50-329 3.22e-18

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 84.83  E-value: 3.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd14971   9 LIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPG---WVFGDFMCKFVHYFQQVSMH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSREL--VMYIWAHAVVASVPVFAVTNVADIYAT--STCTEVWSNSLGHLVY 205
Cdd:cd14971  86 ASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALaaSGCIWVVSLAVAAPVLALHRLRNYTPGnrTVCSEAWPSRAHRRAF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  206 VLvynittvivpvvVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYATL 285
Cdd:cd14971 166 AL------------CTFLFGYLLPLLLICVCYAAMLRHLWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAI 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6005772  286 VVYQTVLNVPDT--SVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd14971 234 LLLVALGPFPLTyaTYALRIWAHCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
49-329 7.34e-18

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 84.02  E-value: 7.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd14992   8 VVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLS---WEYGHFLCKIVNYLRTVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRE--LVMYIWAHAVVASVP-VFAVTNV----ADIYATSTCTEVWSNSLG 201
Cdd:cd14992  85 YASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTviIIITIWVVSLLLAIPqLYYATTEvlfsVKNQEKIFCCQIPPVDNK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 H-------LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIpyasqreaelhatLLSMVMV 274
Cdd:cd14992 165 TyekvyflLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSIKEVERKRLKCKRRVIKM-------------LVCVVVL 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  275 FILCSVPYATLVVYQTVLNVPDTSVFLLLTAV---WLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd14992 232 FVICWLPFHLFFLLRDFFPLIMKEKHTLQVYYflhWIAMSNSMYNPIIYVTLNNNFRK 289
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
49-208 8.54e-18

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 83.56  E-value: 8.54e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15392   8 STIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQ--YWPFGEFMCPVVNYLQAVSV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATST----CTEVWSNSLGHLV 204
Cdd:cd15392  86 FVSAFTLVAISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCgqyiCTESWPSDTNRYI 165

                ....
gi 6005772  205 YVLV 208
Cdd:cd15392 166 YSLV 169
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
50-284 8.87e-18

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 83.61  E-value: 8.87e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15393   9 IISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQR---WVLPRFMCPFCPFVQVLSVN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATST------CTEVWSNSLGHL 203
Cdd:cd15393  86 VSVFTLTVIAVDRYRAVIHPLKARCSKKSAKIIILIIWILALLVALPVALALRVEELTDKTNngvkpfCLPVGPSDDWWK 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVynittviVPVVVVFLFLILIRRALSASQKKkviIAALRTPQNTISIPYASQREA--ELHATLLSMVMVFILCSVP 281
Cdd:cd15393 166 IYNLY-------LVCVQYFVPLVIICYAYTRIAVK---IWGTKAPGNAQDVRDDEILKNkkKVIKMLIIVVALFALCWLP 235

                ...
gi 6005772  282 YAT 284
Cdd:cd15393 236 LQT 238
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
45-329 1.20e-17

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 82.61  E-value: 1.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd14967   3 AVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGY---WPFGPVLCRFWIALD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGH 202
Cdd:cd14967  80 VLCCTASILNLCAISLDRYLAITRPLryRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 LVYVLVYNittvivpvvvvFLFLILIrralsasqkkkVIIAALRtpqntisIPYASQREAELHATLLSMVMVFILCSVPY 282
Cdd:cd14967 160 VLVSSVIS-----------FFIPLLI-----------MIVLYAR-------IFRVARRELKAAKTLAIIVGAFLLCWLPF 210
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6005772  283 ATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd14967 211 FIIYLVSAFCPPDCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRR 257
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
45-328 1.34e-16

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 80.07  E-value: 1.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd15051   4 GVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGE---WPLGPVFCNIYISLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVAS-VPVFAVTNVAD-----IYATSTCTEVW 196
Cdd:cd15051  81 VMLCTASILNLFAISLDRYLAITAPLryPSRVTPRRVAIALAAIWVVSLAVSfLPIHLGWNTPDgrvqnGDTPNQCRFEL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVYVLVYNITTVIVPVVVVFLFLIlirralsASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFI 276
Cdd:cd15051 161 NPPYVLLVAIGTFYLPLLIMCGVYLRIFRI-------AREQAKRINALTPASTANSSKSAATAREHKATVTLAAVLGAFI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  277 LCSVPYATLVVYQTVLNVPDTSVFLLLTaVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15051 234 ICWFPYFTYFTYRGLCGDNINETALSVV-LWLGYANSALNPILYAFLNRDFR 284
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
43-208 1.52e-16

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 80.03  E-value: 1.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15390   2 LWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYND---WPFGLFYCKFSNF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVP--VFAVTN---VADIYATSTCTEVW- 196
Cdd:cd15390  79 VAITTVAASVFTLMAISIDRYIAIVHPLRPRLSRRTTKIAIAVIWLASFLLALPqlLYSTTEtyyYYTGSERTVCFIAWp 158
                       170
                ....*....|....
gi 6005772  197 --SNSLGHLVYVLV 208
Cdd:cd15390 159 dgPNSLQDFVYNIV 172
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
49-329 2.10e-16

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 79.82  E-value: 2.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15205   8 VLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSN---WLGGAFMCKMVPFVQSTAV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAVTNVADIY------ATSTCTEVWSNSL 200
Cdd:cd15205  85 VTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMlgLVWIVSVIVGSPMLFVQQLEVKYdflyekRHVCCLERWYSPT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 GHLVYVLvYNITTVIVPVVVVFLFLiLIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSV 280
Cdd:cd15205 165 QQKIYTT-FILVILFLLPLTTMLFL-YSRIGYELWIKKRVGDASVLQTIHGIEMSKISRKKKRAVKMMVTVVLLFAVCWA 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  281 PYATLVVYQTVLNVP----DTSVFLLLTAVWLPKVS-LLANPVLFLTVNKSVRK 329
Cdd:cd15205 243 PFHVVHMMIEYSNLEnkydGVTIKLIFAIVQLIGFSnSFNNPIVYAFMNENFKK 296
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
49-176 1.09e-15

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 77.38  E-value: 1.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIgSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15389   9 IIIVI-SLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLNTPFTLVRFVNST---WVFGKIMCHLSRFAQYCSV 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVP 176
Cdd:cd15389  85 YVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAIIWIMASCLSLP 132
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
51-329 1.20e-15

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 77.46  E-value: 1.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFK--SVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15098  10 IFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFFLLFCVPFQATIYSLPE---WVFGAFMCKFVHYFFTVSM 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPleRKISDAKSREL----VMYIWAHAVVASVPV---FAVTNVADIYATSTCTEVWSNSLG 201
Cdd:cd15098  87 LVSIFTLVAMSVDRYIAVVHS--RTSSSLRTRRNallgVLVIWVLSLAMASPVavhQDLVHHWTASNQTFCWENWPEKQQ 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 HLVYVLVynittvivpvvvVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAElhATLLSMVMVFILCSVP 281
Cdd:cd15098 165 KPVYVVC------------TFVFGYLLPLLLITFCYAKVLNHLHKKLKNMSKKSERSKKKTA--QTVLVVVVVFGISWLP 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 6005772  282 YATLVVYQTVLNVP--DTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15098 231 HHIIHLWVEFGDFPltQASFVLRITAHCLAYANSCVNPIIYAFLSENFRK 280
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
50-331 2.02e-15

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 76.57  E-value: 2.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLW-STCRTTvfKSVTNRFIKNLACSGIcASLVCVPFDIILSTSPHccWWIYTMLFCKV---VKFLHk 125
Cdd:cd14974   9 LIFLLGLPGNGLVIWvAGFKMK--RTVNTVWFLNLALADF-LFCLFLPFLIVYIAMGH--HWPFGSVLCKLnsfVISLN- 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSfpAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCtevwsnSLGHL 203
Cdd:cd14974  83 MFASVFLLT--AISLDRCLLVLHPVwaQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSC------NLTCV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVYNITTVIVPVVVvFLFLILIRRALSASQKKkVIIAALRtpQNTISIPYASQReaelhaTLLSMVMVFILCSVPYA 283
Cdd:cd14974 155 EDYDLRRSRHKALTVIR-FLCGFLLPLLIIAICYS-VIAVKLR--RKRLAKSSKPLR------VLLAVVVAFFLCWLPYH 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  284 TLVVYQTVLNVPDTSVFLLltavWLPKVSLLA------NPVLFLTVNKSVRKCL 331
Cdd:cd14974 225 VFALLELVAAAGLPEVVLL----GLPLATGLAyfnsclNPILYVFMGQDFRKRL 274
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
47-327 2.63e-15

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 76.35  E-value: 2.63e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKV 126
Cdd:cd15212   6 VLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPG--WLFGDRLCLANGFFNAC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYAtstctevwSNSLGHLVYV 206
Cdd:cd15212  84 FGIVSTLTMTLISFDRYYAIVRQPQGKIGRRRALQLLAAAWLTALGFSLPWYLLASAPEYYE--------KLGFYHCLYV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  207 LVYNITTVIVPVVVVFLFL-------------ILIRRALSASQKKkviIAALRTPQNTISIpYASQREAelhATLLSMVM 273
Cdd:cd15212 156 LHSGPSRLGAAYSSVLIVLcyllpfalmcfchYNICKTVRLSESR---VRPVTTYAHLLRF-YSEMRTA---TTVLIMIV 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  274 VFILCSVPYATLVVYQTVLNVPdTSVFLLLTAVWLPKVSLLANPVLFLTVNKSV 327
Cdd:cd15212 229 FIICCWGPYCLLGLVAAAGGYQ-FPPLMDTVAIWMAWANGAINPLIYAIRNPNI 281
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
45-291 7.25e-15

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 75.16  E-value: 7.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd15397   5 VSYSLVMAVG-LLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVCLPFTVVYTLMDY---WIFGEVLCKMTPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFA---VTNV---------ADIYATSTC 192
Cdd:cd15397  81 CMSVTVSILSLVLIALERHQLIINPTGWKPSVSQAYLAVVVIWMLACFISLPFLAfhiLTDEpyknlshffAPLADKAVC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  193 TEVWSNSLGHLVY---VLVYNITTVIVpvvvvFLFLILIRRALSASQKKKVIiaaLRTPQNTISIPYASQreaeLHATLL 269
Cdd:cd15397 161 TESWPSEHHKLAYttwLLLFQYCLPLL-----FILVCYLRIYLRLRRRKDML---ERRGEYNRRAGHSKR----INVMLV 228
                       250       260
                ....*....|....*....|..
gi 6005772  270 SMVMVFILCSVPyatLVVYQTV 291
Cdd:cd15397 229 SLVAAFALCWLP---LNVFNAI 247
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
45-320 1.12e-14

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 74.68  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd15083   4 GIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGR---WIFGKTGCDMYGFSG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVF----------AVTNVA-DIYATST 191
Cdd:cd15083  81 GLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIViaVVWLYSLLWVLPPLfgwsryvlegLLTSCSfDYLSRDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  192 CTEVWSNSLGHLVYVLVynittvivpvvvvfLFLIL-----IRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHA 266
Cdd:cd15083 161 ANRSYVICLLIFGFVLP--------------LLIIIycysfIFRAVRRHEKAMKEMAKRFSKSELSSPKARRQAEVKTAK 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  267 TLLSMVMVFILCSVPYAtLVVYQTVLNVPDT-SVFLLLTAVWLPKVSLLANPVLF 320
Cdd:cd15083 227 IALLLVLLFCLAWTPYA-VVALIGQFGYLEVlTPLATAIPAAFAKTSAIYNPVIY 280
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
50-209 1.41e-14

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 74.24  E-value: 1.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15095   9 IIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPS---WVFGDFMCKFVNYMMQVTVQ 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLeRKISDAKSRELV---MYIWAHAVVASVPVFAVTNVADIYATST---CTEVWSNSLGHL 203
Cdd:cd15095  86 ATCLTLTALSVDRYYAIVHPI-RSLRFRTPRVAVvvsACIWIVSFLLSIPVAIYYRLEEGYWYGPqtyCREVWPSKAFQK 164

                ....*.
gi 6005772  204 VYVLVY 209
Cdd:cd15095 165 AYMIYT 170
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-328 4.03e-14

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 72.95  E-value: 4.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTspHCCWWiYTMLFCKVVKFLH 124
Cdd:cd16004   4 AIAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYAS--HNDWY-FGLEFCRFQNFFP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLG--- 201
Cdd:cd16004  81 ITAMFVSIYSMTAIAADRYMAIIHPFKPRLSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGgkh 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 HLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQkkkviiaalrTPQNTISIPYASQREA--ELHATLLSMVMVFILCS 279
Cdd:cd16004 161 QLTYHLAVIVLIYLLPLAVMFVTYSIIGITLWRSA----------VPGHQAHGAYHRQLQAkkKFVKTMVVVVVTFAICW 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  280 VPYATLVVYQTVLNVPDTSVFL---LLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd16004 231 LPYHLYFILGSFNEDIYCQKYIqqvYLAIFWLAMSSTMYNPIIYCCLNQRFR 282
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
49-331 5.69e-14

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 72.31  E-value: 5.69e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIlstSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15074   8 TVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAII---SAFAHRWLFGDIGCVFYGFCGFLFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLER-KISDAKSRELVMYIWAHA-VVASVPVFAVTN-VADIYATStCTEVW---SNSLGH 202
Cdd:cd15074  85 CCSINTLTAISIYRYLKICHPPYGpKLSRRHVCIVIVAIWLYAlFWAVAPLVGWGSyGPEPFGTS-CSIDWtgaSASVGG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTIsipyasqreaELHATLLSMVMV--FILCSV 280
Cdd:cd15074 164 MSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSRSKRQHKI----------ERKVTKVAVLICagFLIAWT 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  281 PYA---TLVVYQTVLNVPdTSVFLLLTAvwLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15074 234 PYAvvsMWSAFGSPDSVP-ILASILPAL--FAKSSCMYNPIIYLLFSSKFRQDL 284
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
45-331 5.93e-14

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 72.45  E-value: 5.93e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd14977   4 MSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLCVPLNAYNLLTKD---WLFGDVMCKLVPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASVPVFAVTNVADIYAT-----STCTEVWS 197
Cdd:cd14977  81 VTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVklAVIWVGSVLLAVPEAVLSTVARESSLdnsslTVCIMKPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLghlvyVLVYNITTVIVPVVVVFLFLILIRrALSASQKKKVIIAALRtpQNTISIPYASQREAELHATLLSMVMVFIL 277
Cdd:cd14977 161 TPF-----AETYPKARSWWLFGCYFCLPLAFT-AVCYLLMARTLIRAAK--EYTRGTKKHMKQRRQLAKTVLCLVLVFAF 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  278 CSVPY-----ATLVVYQTVLNVPDTSVFLL-LTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd14977 233 CWLPEhisniLRATLYNEVLIDTRSTLDILdLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
43-331 8.56e-14

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 71.94  E-value: 8.56e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcVPFdiiLSTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLG-LPF---LATSYLLGYWPFGEVMCKIVLS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLE----RKISDAKsreLV-MYIWAHAVVASVPV--FAVTNVADIyATSTCTEV 195
Cdd:cd14970  78 VDAYNMFTSIFCLTVMSVDRYLAVVHPVKslrfRTPRKAK---LVsLCVWALSLVLGLPViiFARTLQEEG-GTISCNLQ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  196 WSN--SLGHLVYVLvynittvivpvvVVFLF-----LILIRRALSAsqkkkvIIAALRTpqnTISIPYASQREAELH--- 265
Cdd:cd14970 154 WPDppDYWGRVFTI------------YTFVLgfavpLLVITVCYSL------IIRRLRS---SRNLSTSGAREKRRArrk 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  266 --ATLLSMVMVFILCSVPYATLVVYQTVLNVPDTSVFLL--LTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd14970 213 vtRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETLTVVGvfLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
55-328 2.43e-13

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 70.62  E-value: 2.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   55 SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCSVTILS 134
Cdd:cd15391  14 SVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGH---WVFPAPMCPIVLYVQLVSVTASVLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  135 FPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATS----TCTEVWSNSLGH------LV 204
Cdd:cd15391  91 NTAIGIDRFFAVIFPLRSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSegrvLCGESWPGPDTSrsaytvFV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIpyasqreaelhatLLSMVMVFILCSVP--- 281
Cdd:cd15391 171 MLLTYIIPLLILTSTYGYVGFRLWNRTAPGNADKGRDDMQIKSKRKVIKM-------------LVFVVLMFGICWLPlhl 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  282 YATLVVYQTVL-NVP-DTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15391 238 FNLVQDFSTVFrNMPqHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFR 286
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-328 2.83e-13

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 70.28  E-value: 2.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGicASLVCVPFDIILSTSPHCCWWiYTMLFCKVVKFLHKVFCS 129
Cdd:cd16002   9 VIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAE--ASMSAFNTVINFTYAIHNEWY-YGLEYCKFHNFFPIAAVF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSlGHLVYVLVY 209
Cdd:cd16002  86 ASIYSMTAIALDRYMAIIHPLQPRLSATATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEH-EERKYETVY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  210 NittVIVPVVVVFLFLILIRRALSASqkkKVIIAALRTPQNTiSIPYASQREAELHATLLSMVMV--FILCSVPYATLVV 287
Cdd:cd16002 165 H---VCVTVLIYFLPLLVIGCAYTVV---GITLWASEIPGDS-SDRYHEQVSAKRKVVKMMIVVVctFAICWLPYHIYFL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6005772  288 YQTVLNVPDTSVFL---LLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd16002 238 LQYFHPELYEQKFIqqvYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
47-328 4.34e-13

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 69.96  E-value: 4.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILS----TSPHCCWWiytmLFCKVVkf 122
Cdd:cd15069   6 LELIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISlgfcTDFHSCLF----LACFVL-- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 lhkVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVFAVTNVADIyATSTCTEVWSNSL 200
Cdd:cd15069  80 ---VLTQSSIFSLLAVAVDRYLAIKVPLRYKslVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMS-ATNNSTNPADHGT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 GH---LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYAS---QREAELHATLLSMVMV 274
Cdd:cd15069 156 NHsccLISCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRttlQREIHAAKSLAIIVGI 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  275 FILCSVPY-----ATLVVYQTVLNVPDtsvFLLLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15069 236 FALCWLPVhilncITLFQPEFSKSKPK---WAMNVAILLSHANSVVNPIVYAYRNRDFR 291
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
45-328 4.72e-13

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 69.83  E-value: 4.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICaSLVCVPFDIIlstSPHCCW-WIYTMLFCKVVKFL 123
Cdd:cd15928   4 TAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLL-IFLVLPLDLY---RLWRYRpWRFGDLLCRLMYFF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATST-----CTEVW 196
Cdd:cd15928  80 SETCTYASILHITALSVERYLAICHPLRAKvlVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTprgfeCTVVN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIpyasqreaelhATLLSMVMVFI 276
Cdd:cd15928 160 VSSGLLSVMLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRDNNHRQTV-----------RMLAVIVLAFV 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  277 LCSVP-----YATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15928 229 LCWLPfhvgrVIFNHSRASTKHLHYVSQYFNLVSFVLFYLSAAINPILYNLMSKRYR 285
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
49-324 5.97e-13

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 68.99  E-value: 5.97e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSgICASLVCVPFDIILSTSPHccWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd14964   6 SLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAAC-DLLASLVVLVLFFLLGLTE--ASSRPQALCYLIYLLWYGAN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYatSTCTEVWSNSLGHLVYV 206
Cdd:cd14964  83 LASIWTTLVLTYHRYFALCGPLKytRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRY--NTLTGSCYLICTTIYLT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  207 LVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTisipyasqreaELHATLLSMVMVFILCSVPYATLV 286
Cdd:cd14964 161 WGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKNL-----------KATKSLLILVITFLLCWLPFSIVF 229
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6005772  287 VYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVN 324
Cdd:cd14964 230 ILHALVAAGQGLNLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
50-329 7.46e-13

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 69.08  E-value: 7.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15399  10 IILLG-VVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVNTLCLPFTLVYTLLDE---WKFGAVLCHLVPYAQALAVH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPV-----FAVTNVADIYATSTCTEVWSNslGHLV 204
Cdd:cd15399  86 VSTVTLTVIALDRHRCIVYHLESKISKKISFLIIGLTWAASALLASPLaifreYSVIEISPDFKIQACSEKWPN--GTLN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNittvivpvvvvfLFLILIRRALSASQKKKVIIAALRTPQNTISiPYAS-----QREAELHATLLSMVMVFILCS 279
Cdd:cd15399 164 DGTIYS------------VSMLLIQYVLPLAIISYAYIRIWTKLKNHVS-PGGGndhyhQRRRKTTKMLVCVVVVFAVSW 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 6005772  280 VPYATLVVYQTV-LNVPDTSVFLLLTAVW--LPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15399 231 LPFHAFQLASDIdSKVLDLKEYKLIYTIFhvIAMCSTFANPLLYGWMNNNYRT 283
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
46-330 7.61e-13

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 68.96  E-value: 7.61e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIlstsphccwWIYTM------LFCKV 119
Cdd:cd15195   5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAV---------WNYTVewlagdLMCRV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  120 VKFLhKVFcSVTILSF--PAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNV----ADIYATSTCt 193
Cdd:cd15195  76 MMFL-KQF-GMYLSSFmlVVIALDRVFAILSPLSANQARKRVKIMLTVAWVLSALCSIPQSFIFSVlrkmPEQPGFHQC- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  194 eVWSNSLGHLVYVLVYNITTVIVPVVVVFLFLI----LIRRALSASQKK-KVIIAALRTPQNTISIPYASQREAELHATL 268
Cdd:cd15195 153 -VDFGSAPTKKQERLYYFFTMILSFVIPLIITVtcylLILFEISKMAKRaRDTPISNRRRSRTNSLERARMRTLRMTALI 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  269 lsmVMVFILCSVPYATLVVY-----QTVLNVPDTSVFLLLTAVWLPKVsllANPVLFLTVNKSVRKC 330
Cdd:cd15195 232 ---VLTFIVCWGPYYVLGLWywfdkESIKNLPPALSHIMFLLGYLNPC---LHPIIYGVFMKEIRNW 292
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
43-178 7.98e-13

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 68.56  E-value: 7.98e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15066   1 LKGFAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGR---WMFGYFMCDVWNS 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMY--IW-AHAVVASVPVF 178
Cdd:cd15066  78 LDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLanVWiSPALISFLPIF 136
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
44-331 8.40e-13

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 69.41  E-value: 8.40e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIgSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFdiILSTSPHCCWWIYTMLFCKVVKFL 123
Cdd:cd15005   4 LTTLGLILCV-SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPF--VMASVRHGSGWIYGALSCKVIAFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYP--LERKISDAKSRELVMYIWAHAVVASV-PVFAVTNVADIYATSTCT----EVW 196
Cdd:cd15005  81 AVLFCFHSAFTLFCIAVTRYMAIAHHrfYAKRMTFWTCLAVICMAWTLSVAMAFpPVFDVGTYTFIREEDQCTfehrSYK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SN-SLGHLVyVLVYNITTVIVPVVVVFLFLILIRR--------ALS-------------ASQKKKVIIAALRTPQNTISI 254
Cdd:cd15005 161 ANdTLGFML-VLAVVIAATHLVYLKLLIFLRHHRKmkpaqlvpAISqnwtfhgpgatgqAAANWTAGFGRGPTPPTLLGI 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  255 PYAS-------------QREAELHATLLSMVMVFILCSVPYatlVVYQTVLNVPDTSVF---LLLTAVWLPKVSLLANPV 318
Cdd:cd15005 240 RQAFhsgarrllvldefKMEKRLTRMFYAITLLFLLLWSPY---IVACYIRVFVRGYAVpqgFLTAAVWMTFAQAGVNPI 316
                       330
                ....*....|...
gi 6005772  319 LFLTVNKSVRKCL 331
Cdd:cd15005 317 VCFFFNRELRKCL 329
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
45-329 9.59e-13

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 68.45  E-value: 9.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcASLVCVPFDIILSTSPHccWWIYTMLFCKVVKFLH 124
Cdd:cd14982   4 PIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADL-LFVLTLPFRIYYYLNGG--WWPFGDFLCRLTGLLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVFAVTN-VADIYATSTCTEVWSNSLG 201
Cdd:cd14982  81 YINMYGSILFLTCISVDRYLAVVHPLKSRrlRRKRYAVGVCAGVWILVLVASVPLLLLRStIAKENNSTTCFEFLSEWLA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 HLVYVLVYnittvivpvVVVFLFLI----------LIRRALS----ASQKKKVIIAALRtpqntisipyasqreaelhaT 267
Cdd:cd14982 161 SAAPIVLI---------ALVVGFLIplliilvcysLIIRALRrrskQSQKSVRKRKALR--------------------M 211
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  268 LLSMVMVFILCSVPY-ATLVVYQTV-------LNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd14982 212 ILIVLAVFLVCFLPYhVTRILYLLVrlsfiadCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
50-330 1.00e-12

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 68.19  E-value: 1.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15206   9 VIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRN---FIFGEVMCKLIPYFQAVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSR--ELVMYIWAHAVVASVPVFAVTNVADIY--ATSTCTEVWSNSLGHLVY 205
Cdd:cd15206  86 VSTFTLVAISLERYFAICHPLKSRVWQTLSHayKVIAGIWLLSFLIMSPILVFSNLIPMSrpGGHKCREVWPNEIAEQAW 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  206 VLVYNITTVIVPVVVVFLFLILIRRALSASqKKKVIiaalrtpqntisipyasqreaelhATLLSMVMVFILCSVP---- 281
Cdd:cd15206 166 YVFLDLMLLVIPGLVMSVAYGLISWTLLEA-KKRVI------------------------RMLFVIVVEFFICWTPlyvi 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  282 -----YATLVVYQTVLNVPDTSVFLlltavwLPKVSLLANPVLFLTVNKSVRKC 330
Cdd:cd15206 221 ntwkaFDPPSAARYVSSTTISLIQL------LAYISSCVNPITYCFMNKRFRQA 268
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-328 1.01e-12

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 68.67  E-value: 1.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFDI--ILSTSPhccwWIYTMLFCKVVKF 122
Cdd:cd15132   4 TIVCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLI-LLCLPFDLyrLWKSRP----WIFGEFLCRLYHY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSR--ELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVW---- 196
Cdd:cd15132  79 ISEGCTYATILHITALSIERYLAICFPLRAKVLVTRRRvkCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSReckh 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 ------SNSLGHLVYVlvynittvivpVVVVFLFLILIRRALSASQKKKviiaaLRTPQNTISIPYASQREAELHAT--- 267
Cdd:cd15132 159 tpyavsSGLLGIMIWV-----------TTTYFFLPMLCLSFLYGFIGRK-----LWKSKNDLRGPNAAARERSHRQTvri 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  268 LLSMVMVFILCSVPYAtlVVYQTVLNVPDTSVFLL-----LTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15132 223 LAVVVLAFIICWLPFH--IGRILFANTEDYRTMMFsqyfnIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
45-282 1.10e-12

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 68.47  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPfDIILSTSPHCCWWI-YTMlfCKVVKFL 123
Cdd:cd14997   4 SVVYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMP-VALVETWAREPWLLgEFM--CKLVPFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAVTNVADI-----YATSTCtEVW 196
Cdd:cd14997  81 ELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIiaLIWLLALLTSSPVLFITEFKEEdfndgTPVAVC-RTP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVYVLVynittvivpVVVVFLFLILIRRALSASqkkkVIIAALRTPQNTISIPYASQREAELHA------TLLS 270
Cdd:cd14997 160 ADTFWKVAYILS---------TIVVFFVVPLAILSGLYS----VICRRLVGHPALESRRADAANRHTLRSrrqvvyMLIT 226
                       250
                ....*....|..
gi 6005772  271 MVMVFILCSVPY 282
Cdd:cd14997 227 VVVLFFVCLLPF 238
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
50-208 1.24e-12

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 68.32  E-value: 1.24e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15008   8 VLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGR---WTLGSAMCKLVRYFQYLTPG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWA-HAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVYVLV 208
Cdd:cd15008  85 VQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMIAASWLfDAAFVSPALFFYGSNWGPHCNFFLPDSWDGAAYAIIHLLV 164
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
50-282 1.86e-12

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 67.79  E-value: 1.86e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKV--F 127
Cdd:cd14986   9 VLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIWEATGE---WVAGDVLCRIVKYLQVVglF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  128 CSVTILSfpAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVP---VFAVTNVADIyaTSTCTEVWSNSLGHLV 204
Cdd:cd14986  86 ASTYILV--SMSLDRYQAIVKPMSSLKPRKRARLMIVVAWVLSFLFSIPqlvIFVERELGDG--VHQCWSSFYTPWQRKV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YV-----LVYNITTVIVPVVVVFLFLILIRRalsASQKKKVIIA--------ALRTPQNTISIPYASQREAELHATLlsm 271
Cdd:cd14986 162 YItwlatYVFVIPLIILSYCYGRILRTIWIR---SRQKTDRPIAptamscrsVSCVSSRVSLISRAKIKTIKMTLVI--- 235
                       250
                ....*....|.
gi 6005772  272 VMVFILCSVPY 282
Cdd:cd14986 236 ILAFILCWTPY 246
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
50-282 2.95e-12

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 67.29  E-value: 2.95e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15927   9 LIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDS---WPFGEFLCKLSEFLKDTSIG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSlghLVYVL 207
Cdd:cd15927  86 VSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVtaASIWIVSILLAIPEAIFSHVVTFTLTDNQTIQICYP---YPQEL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  208 VYNITTVIVPVVVVFLFLI--LIRRALSASQKKKVIIAALRTPQNTISipyASQREAE----LHATLLSMVMVFILCSVP 281
Cdd:cd15927 163 GPNYPKIMVLLRFLVYYLIplLIIGVFYVLMARHLIRSTRNIGSGQNQ---AAQRQIEarkkVAKTVLAFVVLFAVCWLP 239

                .
gi 6005772  282 Y 282
Cdd:cd15927 240 R 240
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
49-329 4.46e-12

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 66.83  E-value: 4.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVP---FDIILSTsphccwWIYTMLFCKVVKFLHK 125
Cdd:cd15980   8 LLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIFCMPttlLDNIIAG------WPFGSTVCKMSGMVQG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADI--------YATST-----C 192
Cdd:cd15980  82 ISVSASVFTLVAIAVDRFRCIVYPFKQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEknyrvvlgSQNKTspvywC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  193 TEVWSNSLGHLVYVLV-----YNITTVIVPVVVVFLFLILIRRALSASQKKKviiaalRTPQNTIsipyaSQREAELHAT 267
Cdd:cd15980 162 REDWPNQEMRKIYTTVlfaniYLAPLSLIVIMYARIGITLFKTAMPHTGKHN------QEQRHVV-----SRKKQKVIKM 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  268 LLSMVMVFILCSVPYATLVVYQTVLNVPDT-----SVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15980 231 LLIVALLFILSWLPLWTLMMLSDYANLSPNqlqiiNIYIYPFAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
49-329 4.71e-12

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 66.68  E-value: 4.71e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15073   8 IVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGS---WKFGYAGCQWYAFLNIFFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYP-LERKISDAKSRELVMYIWAHAVV-ASVPVFAVTNVADIYATSTCTEVWS-NSLGHLVY 205
Cdd:cd15073  85 MASIGLLTVVAVDRYLTICRPdLGRKMTTNTYTVMILLAWTNAFFwAAMPLVGWASYALDPTGATCTINWRkNDSSFVSY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  206 VLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAalrtpqntISIPYASQReaelHATLLSMVMV--FILCSVPYA 283
Cdd:cd15073 165 TMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLES--------VNIDWTDQN----DVTKMSVIMIvmFLVAWSPYS 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6005772  284 TLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15073 233 IVCLWASFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRR 278
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-183 5.56e-12

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 66.23  E-value: 5.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFdiilSTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd15182   2 FLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTF-TLPF----WASYHSSGWIFGEILCKAVTS 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLerkiSDAKSRELV------MYIWAHAVVASVPVFAVTNV 183
Cdd:cd15182  77 IFYIGFYSSILFLTLMTIDRYLAVVHPL----SALRSRKLRyaslvsVAVWVISILASLPELILSTV 139
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
49-331 9.53e-12

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 65.65  E-value: 9.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLL---GNFMVLWSTcrtTVFK---SVTNRFIKNLACSGICASLVCVPFDIILSTSPhcCWWiYTMLFCKVVKF 122
Cdd:cd15055   5 IVLSSISLLtvlGNLLVIISI---SHFKqlhTPTNLLLLSLAVADFLVGLLVMPFSMIRSIET--CWY-FGDTFCKLHSS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVV-ASVPVFAVTNVADIYATSTCtevwsns 199
Cdd:cd15055  79 LDYILTSASIFNLVLIAIDRYVAVCDPLlyPTKITIRRVKICICLCWFVSALySSVLLYDNLNQPGLIRYNSC------- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGhlVYVLVYNITTVIVPVVVVFLFLILI------RRALSASQKKKVI---IAALRTPQNTISIPYASQREAelhATLLS 270
Cdd:cd15055 152 YG--ECVVVVNFIWGVVDLVLTFILPCTVmivlymRIFVVARSQARAIrshTAQVSLEGSSKKVSKKSERKA---AKTLG 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  271 MVM-VFILCSVPYatlvvYQTVLNVPDTSVFLLLTAV--WLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15055 227 IVVgVFLLCWLPY-----YIVSLVDPYISTPSSVFDVliWLGYFNSCLNPLIYALFYPWFRKAL 285
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
45-282 9.97e-12

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 65.68  E-value: 9.97e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFDI--ILSTSPhccwWIYTMLFCKVVKF 122
Cdd:cd15131   4 TVTCVLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLI-FLCMPLDLyrLWQYRP----WNFGDLLCKLFQF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVFAVTNV-----ADIYATSTC--T 193
Cdd:cd15131  79 VSESCTYSTILNITALSVERYFAICFPLRAKvvVTKRRVKLVILVLWAVSFLSAGPIFVLVGVehengTNPIDTNECkaT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  194 EVWSNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIpyasqreaelhATLLSMVM 273
Cdd:cd15131 159 EYAVRSGLLTIMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRRENIGPNASHRDKNNRQTV-----------KMLAVVVF 227

                ....*....
gi 6005772  274 VFILCSVPY 282
Cdd:cd15131 228 AFVLCWLPF 236
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
45-150 1.21e-11

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 65.35  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPhcCWWIYTMLF--CKVVkf 122
Cdd:cd14968   4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGL--PTNFHGCLFmaCLVL-- 79
                        90       100
                ....*....|....*....|....*...
gi 6005772  123 lhkVFCSVTILSFPAIALDRYYSVLYPL 150
Cdd:cd14968  80 ---VLTQSSIFSLLAIAIDRYLAIKIPL 104
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
46-331 1.67e-11

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 65.24  E-value: 1.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHK 125
Cdd:cd15396   5 IAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMCIPFTAVYTLMDH---WIFGETMCKLTSFVQS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFA-----------VTNVADIYATS-TCT 193
Cdd:cd15396  82 VSVSVSIFSLVLIAIERYQLIVNPRGWKPSASHAYWGIVLIWLFSLMISIPFLIfhqltdepfrnLSSHSDFYKDKvVCI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  194 EVWSNSLGHLVY---VLVYNittviVPVVVVFLFLILIRRALSAsQKKKVIIAALRTPQNTISipyASQReaeLHATLLS 270
Cdd:cd15396 162 EAWPSETERLIFttsLLVFQ-----YFVPLGFIFICYLKIFVCL-KKRNSKIDRMRENESRLS---ENKR---INTMLIS 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  271 MVMVFILCSVPYATLVV-----YQTVLNVPDTSVFLLLTAVWLpkVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15396 230 IVVTFAACWLPLNIFNVvfdwnHEVLMSCHHNLVFTLCHLVAM--VSTCINPIFYGFLNKNFQKDL 293
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
45-178 3.14e-11

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 64.30  E-value: 3.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILStsphccWWIYT----MLFCKVV 120
Cdd:cd14979   4 TAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNF------WWQYPwafgDGGCKLY 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  121 KFLHKVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVF 178
Cdd:cd14979  78 YFLFEACTYATVLTIVALSVERYVAICHPLKAKtlVTKRRVKRFILAIWLVSILCAIPIL 137
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
45-293 3.40e-11

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 64.00  E-value: 3.40e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd15384   4 IVVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVA---WLAGNTMCKLVKYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 --KVFCSVTILSfpAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVA------DIYATST---CT 193
Cdd:cd15384  81 vfGLYLSTYITV--LISLDRCVAILYPMKRNQAPERVRRMVTVAWILSPIFSIPQAVIFHVErgpfveDFHQCVTygfYT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  194 EVWSNSLgHLVYVLVYNITTVIVPVVVVFLfLILIRRALSASQKKKVIIAAL-RTPQNTISIPYASQREAELHATLlsmV 272
Cdd:cd15384 159 AEWQEQL-YNMLSLVFMFPIPLVIMVTCYV-LIFITLSKSSRDFQGLEIYTRnRGPNRQRLFHKAKVKSLRMSAVI---V 233
                       250       260
                ....*....|....*....|.
gi 6005772  273 MVFILCSVPYATLVVYQTVLN 293
Cdd:cd15384 234 TAFILCWTPYYVIMIWFLFFN 254
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
58-329 4.44e-11

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 63.83  E-value: 4.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   58 GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFD----IILSTSphccwWIYTMLFCKVVKFLHKVFCSVTIL 133
Cdd:cd15204  17 GNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFCLPFEmdyyVVRQRS-----WTHGDVLCAVVNYLRTVSLYVSTN 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  134 SFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVP--VFAVTNVADIYATSTCTEVWsnSLGHLVYVLVYni 211
Cdd:cd15204  92 ALLVIAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPsaVYSKTTPYANQGKIFCGQIW--PVDQQAYYKAY-- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  212 ttvivpvvvvFLFLILIRRALSasqkkkVIIAAL------------RTP-QNTISIPYASQREAELHATLLSMVMVFILC 278
Cdd:cd15204 168 ----------YLFLFVLEFVLP------VLIMTLcylrivrkvwfrRVPgQQTEQIRRRLRRRRRKVRLLVVILTAFVLC 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  279 SVPYATLVV----YQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15204 232 WAPYYGYAIvrdfFPTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRK 286
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
50-331 4.55e-11

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 63.88  E-value: 4.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVC-VPfdiILSTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15337   9 IVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgFP---LKTISSFNKKWIWGKVACELYGFAGGIFG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASV-PVFAVTN-VADIYATSTCTEVWSNSLGHLV 204
Cdd:cd15337  86 FMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMiiIIWLWSLLWSIpPFFGWGRyVPEGFQTSCTFDYLSRDLNNRL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNITTVIVPVVVVFLFLILIRRALSaSQKKKVIIAALRTPQNTISIPYASQReAELHATLLSMVMV--FILCSVPY 282
Cdd:cd15337 166 FILGLFIFGFLCPLLIIIFCYVNIIRAVR-NHEKEMTQTAKSGMGKDTEKNDARKK-AEIRIAKVAIILIslFLLSWTPY 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 6005772  283 ATLvvyqTVLNVPDTSVFLLLTAVWLP----KVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15337 244 AVV----ALLGQFGPAYWITPYVSELPvmfaKASAIYNPIIYALSHPKFRAAL 292
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
49-283 4.80e-11

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 63.75  E-value: 4.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcaslvcvpfdIILSTSPHCC------WWIYTMLFCKVVKF 122
Cdd:cd15079   8 IFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDF----------LMMIKMPIFIynsfyeGWALGPLGCQIYAF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLE-RKISDAKSRELVMYIWAHAVVASVPVFAVT---NVADIYATSTCTEVWSN 198
Cdd:cd15079  78 LGSLSGIGSIWTNAAIAYDRYNVIVKPLNgNPLTRGKALLLILFIWLYALPWALLPLLFGwgrYVPEGFLTSCSFDYLTR 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  199 SLGHLVYVLVYnittvivpvvvvFLF-----LILI--------------RRALSAsQKKKVIIAALRTPQNtisipyASQ 259
Cdd:cd15079 158 DWNTRSFVATI------------FVFayvipLIIIiycysfivkavfahEKALRE-QAKKMNVVSLRSNAD------ANK 218
                       250       260
                ....*....|....*....|....*.
gi 6005772  260 REAE--LHATLLSMVMVFILCSVPYA 283
Cdd:cd15079 219 QSAEirIAKVALTNVFLWFIAWTPYA 244
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
49-329 5.09e-11

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 63.69  E-value: 5.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDII--LSTSphccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15981   8 LFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVdnLITG-----WPFDNAMCKMSGLVQGM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPV------------FAVTNVADIYATSTCTE 194
Cdd:cd15981  83 SVSASVFTLVAIAVERFRCIVHPFRQKLTLRKAIVTIVIIWVLALIIMCPSavtltvtreehhFMVDDYNNSYPLYSCWE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  195 VWSNSLGHLVYVLVYNITTVIVPvvvvfLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMV 274
Cdd:cd15981 163 AWPDTEMRKIYTTVLFSHIYLAP-----LTLIVIMYARIAFKLFKSSAPIRGSQGEEEEGRRVSKRKIKVINMLIIVALF 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  275 FILCSVPYATLVVYQTVLNVPD-----TSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15981 238 FTLSWLPLWTLMLLTDYGHLSEdqlnlVTVYVFPFAHWLAFFNSSVNPIIYGYFNENFRR 297
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-192 5.46e-11

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 64.03  E-value: 5.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772    45 TTVQVVIFIGSLLGNFMVLWSTCRTTVfKSVTNRFIKNLACSGICASLVcVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:PHA03087  44 IVVYSTIFFFGLVGNIIVIYVLTKTKI-KTPMDIYLLNLAVSDLLFVMT-LPFQIYYYILFQ---WSFGEFACKIVSGLY 118
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASVPVFAVTNVADIYATSTC 192
Cdd:PHA03087 119 YIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIvsLVIWIISIIETTPILFVYTTKKDHETLIC 188
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
49-320 5.87e-11

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 63.25  E-value: 5.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFdiiLSTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15093   9 VVCLVG-LCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFML-GLPF---LAASNALRHWPFGSVLCRLVLSVDGINM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLE----RKISDAKSreLVMYIWAHAVVASVPVFAVTNVADI-YATSTCTEVWSN----- 198
Cdd:cd15093  84 FTSIFCLTVMSVDRYLAVVHPIKsarwRRPRVAKV--VNLAVWVASLLVILPVVVFAGTRENqDGSSACNMQWPEpaaaw 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  199 SLGHLVYVLVYNITTVIVPVVVVFLFLILirralsasqkkKVIIAALRTPQNTisipyasQREAELHATLL--SMVMVFI 276
Cdd:cd15093 162 SAGFIIYTFVLGFLLPLLIICLCYLLIVI-----------KVKSAGLRAGWQQ-------RKRSERKVTRMvvMVVVVFV 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6005772  277 LCSVPYATLVVYQTVLNVPDTSVFLLLT--AVWLPKVSLLANPVLF 320
Cdd:cd15093 224 ICWLPFYVLQLVNVFVQLPETPALVGVYhfVVILSYANSCANPILY 269
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
55-328 7.81e-11

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 63.03  E-value: 7.81e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   55 SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGicASLVCVPFDIILSTSPHCCWWiYTMLFCKVVKFLHKVFCSVTILS 134
Cdd:cd16003  14 AVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSD--ASMAAFNTLINFIYALHSEWY-FGEAYCRFHNFFPITSVFASIYS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  135 FPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLG-HLVY-----VLV 208
Cdd:cd16003  91 MTAIAVDRYMAIIDPLKPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGGPDqHFTYhiiviVLV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  209 YnittvivpvvvvflFLILIRRALSASqKKKVIIAALRTPQNTiSIPYASQREAELHAT--LLSMVMVFILCSVPYATLV 286
Cdd:cd16003 171 Y--------------CLPLLVMGITYT-IVGITLWGGEIPGDT-SDKYHEQLRAKRKVVkmMIIVVLTFAICWLPYHIYF 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 6005772  287 VYQTVLNVPDTSVFL---LLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd16003 235 IVTGLYQQLNRWKYIqqvYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
46-320 9.19e-11

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 62.65  E-value: 9.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSphCCWWIYTMLF--CKVVkfl 123
Cdd:cd15068   5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTG--FCAACHGCLFiaCFVL--- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 hkVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASV-PVF----AVTNVADIYATSTCTEVW 196
Cdd:cd15068  80 --VLTQSSIFSLLAIAIDRYIAIRIPLRYNglVTGTRAKGIIAICWVLSFAIGLtPMLgwnnCGQPKEGKNHSQGCGEGQ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVYVLVYnittvivPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQR-----EAELHA--TLL 269
Cdd:cd15068 158 VACLFEDVVPMNY-------MVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERarstlQKEVHAakSLA 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  270 SMVMVFILCSVPYATLVVYqtVLNVPDTS---VFLLLTAVWLPKVSLLANPVLF 320
Cdd:cd15068 231 IIVGLFALCWLPLHIINCF--TFFCPDCShapLWLMYLAIVLSHTNSVVNPFIY 282
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
50-331 1.35e-10

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 62.13  E-value: 1.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLW--STCRTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKVF 127
Cdd:cd14976   9 VVFTVGLLGNLLVLYllKSNKKLRQQSESNKFVFNLALTDLIFVLT-LPFWAVEYALDFV--WPFGTAMCKVVRYVTKLN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  128 CSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVP--VFAVTNVADIYATSTCTEVWSNSLGHL 203
Cdd:cd14976  86 MYSSIFFLTALSVTRYIAVARALKhgWIRKAFGAFATTIAIWAAAALAAIPeaIFSTDTWSSVNHTLCLLRFPKNSSVTR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLvynittvivpvvvvflflilirraLSASQKKKVIIAALrTPQNTISIPYA-------------SQREAELHATLLS 270
Cdd:cd14976 166 WYNW------------------------LGMYQLQKVVLGFF-LPLGIITLSYLlllrflqrkrggsKRRKSRVTKSVFI 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  271 MVMVFILCSVPYATLVVYQTV---LNVPDTSVFLLLTAVWLPKVSLLA------NPVLFLTVNKSVRKCL 331
Cdd:cd14976 221 VVLSFFICWLPNQALSLWSALikfDDVPFSDAFFAFQTYAFPVAICLAhsnsclNPVLYCLVRREFRDAL 290
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
46-329 1.71e-10

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 62.12  E-value: 1.71e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHK 125
Cdd:cd15056   5 TFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNR---WIYGETFCLVRTSLDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSFPAIALDRYYS-VLYPLERKISDAKSRELVMYIWAHAVVAS-VPVFAVTNVADIYATSTCtevwSNSLGHL 203
Cdd:cd15056  82 LLTTASIMHLCCIALDRYYAiCCQPLVYKMTPLRVAVMLGGCWVIPTFISfLPIMQGWNHIGIEDLIAF----NCASGST 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVYNITTVIVPVVVVF----LFLILirralsasQKKKVIIAALRTPQNTISIPYASQREAELH-------------A 266
Cdd:cd15056 158 SCVFMVNKPFAIICSTVAFyipaLLMVL--------AYYRIYVAAREQAHQIRSLQRAGSSNHEADqhrnsrmrtetkaA 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  267 TLLSMVM-VFILCSVPYATLVVYQTVLN--VPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15056 230 KTLGIIMgCFCVCWAPFFVTNIVDPFIGyrVPYL---LWTAFLWLGYINSGLNPFLYAFFNKSFRR 292
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
50-196 4.22e-10

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 60.77  E-value: 4.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPF---DIILSTsphccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15096   9 LIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFtatDYVLPT------WPFGDVWCKIVQYLVYV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPL-------ERKISDAksrelVMYIWAHAVVASVPVFAVTNVADIY----ATSTCTEV 195
Cdd:cd15096  83 TAYASVYTLVLMSLDRYLAVVHPItsmsirtERNTLIA-----IVGIWIVILVANIPVLFLHGVVSYGfsseAYSYCTFL 157

                .
gi 6005772  196 W 196
Cdd:cd15096 158 T 158
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-176 4.61e-10

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 60.52  E-value: 4.61e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15197   9 VLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGLINVLTDIIWRITVE---WRAGDFACKVIRYLQVVVTY 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVP 176
Cdd:cd15197  86 ASTYVLVALSIDRYDAICHPMNFSQSGRQARVLICVAWILSALFSIP 132
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
56-330 5.55e-10

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 60.20  E-value: 5.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   56 LLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPhccWWIYTMLFCKVVKFLHKVFCSVTILSF 135
Cdd:cd15063  15 VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLD---VWIFGHTWCQIWLAVDVWMCTASILNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  136 PAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHA-VVASVPVFAVTNVADIYATST------CTEVWSNSLGHLVYv 206
Cdd:cd15063  92 CAISLDRYLAITRPIRYPslMSTKRAKCLIAGVWVLSfVICFPPLVGWNDGKDGIMDYSgssslpCTCELTNGRGYVIY- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  207 lvynittvivPVVVVFLFLILIrralsasqkkkVIIAALRtpqntisIPYASQREAELHATLLSMVMVFILCSVPYAT-- 284
Cdd:cd15063 171 ----------SALGSFYIPMLV-----------MLFFYFR-------IYRAARMETKAAKTVAIIVGCFIFCWLPFFTvy 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6005772  285 LVVYQTVLNVPDtsvFLLLTAVWLPKVSLLANPVLFLTVNKSVRKC 330
Cdd:cd15063 223 LVRAFCEDCIPP---LLFSVFFWLGYCNSALNPCIYALFSRDFRFA 265
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
50-197 6.50e-10

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 60.22  E-value: 6.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRT-TVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15097   9 LIFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEG---WVFGSFLCKAVHFFIYLTM 85
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLerkisdaKSREL---------VMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWS 197
Cdd:cd15097  86 YASSFTLAAVSVDRYLAIRYPL-------RSRELrtprnavaaIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGWE 156
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
47-331 6.81e-10

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 60.06  E-value: 6.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLL----GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIlsTSPHCCWWiYTMLFCKVVKF 122
Cdd:cd15312   2 AMYLFMAGAILltvfGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMV--RSVESCWY-FGDLFCKIHSS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAH-AVVASVPVFAVTN-------VADIYATSTC 192
Cdd:cd15312  79 LDMMLSTTSIFHLCFIAVDRYYAVCDPLHyrTKITTPVIKVFLVISWSVpCLFAFGVVFSEVNlegiedyVALVSCTGSC 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  193 tevwsnslghlvyVLVYNITTVIVPVVVVFLFL------ILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHA 266
Cdd:cd15312 159 -------------VLIFNKLWGVIASLIAFFIPgtvmigIYIKIFFVARKHAKVINNRPSVTKGDSKNKLSKKKERKAAK 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  267 TlLSMVM-VFILCSVPYATLVVYQTVLNVpDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15312 226 T-LSIVMgVFLLCWLPFFVATLIDPFLNF-STPVDLFDALVWLGYFNSTCNPLIYGFFYPWFQKAF 289
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
49-320 7.98e-10

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 59.69  E-value: 7.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDI--ILSTSphccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15213   9 LMIFVG-FLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVCMPFAAvtIITGR-----WIFGDIFCRISAMLYWF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLErKISDAKSRELVMYIWAHAVVASVP-VFAVTNVADIYATSTCTEVWSNSLGHLVY 205
Cdd:cd15213  83 FVLEGVAILLIISVDRYLIIVQRQD-KLNPHRAKILIAVSWVLSFCVSFPpLVGWGKYEFPPRAPQCVLGYTESPADRIY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  206 VLVYnittvivpvvVVFLFLILIRRALSAsqkkkvIIAALRTPQNTisipyasqrEAELHATLLSMVMVFILCSVPYATL 285
Cdd:cd15213 162 VVLL----------LVAVFFIPFLIMLYS------YFCILNTVRSF---------KTRAFTTILILFIGFSVCWLPYTVY 216
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6005772  286 VVYqTVLNVPDTSVFLLLT-AVWLPKVSLLANPVLF 320
Cdd:cd15213 217 SLL-SVFSRYSSSFYVISTcLLWLSYLKSAFNPVIY 251
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
50-178 1.03e-09

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 59.14  E-value: 1.03e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPhccWWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15325   9 GFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILG---YWAFGRVFCNIWAAVDVLCCT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSREL--VMYIWAHAVVASV-PVF 178
Cdd:cd15325  86 ASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLlaLLCVWVLSLVISIgPLF 137
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
50-330 1.14e-09

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 59.37  E-value: 1.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcasLVCV---PFDIILSTSPHccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15086   9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDL---LVCVlgtPFSFAASTQGR---WLIGEHGCRWYGFANSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLERKISD-AKSRELVMYIWAHAVVASVP-VFAVTNVADIYATSTCTEVW-SNSLGHL 203
Cdd:cd15086  83 FGIVSLISLAVLSYERYCTLLRPTEADVSDyRKAWLGVGGSWLYSLLWTLPpLLGWSSYGPEGPGTTCSVQWtSRSANSI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVynittvivpvvvVFLFLILIRRALSASQKKKVIIAALRTpqNTISIPYASQREAELHATLLSMVMVFILCSVPYA 283
Cdd:cd15086 163 SYIIC------------LFIFCLLLPFLVMVYCYGRLLYAIKQV--GKINKSTARKREQHVLLMVVTMVICYLLCWLPYG 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6005772  284 TLVVYQTV----LNVPDTSVFLLLtavwLPKVSLLANPVLFLTVNKSVRKC 330
Cdd:cd15086 229 VMALLATFgkpgLVTPVASIVPSI----LAKSSTVVNPIIYVFMNKQFYRC 275
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-193 1.19e-09

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 59.58  E-value: 1.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHK 125
Cdd:cd15125   5 SLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEE---WMFGTVGCKLIPVIQL 81
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASVPVFAVTNVADIYATSTCT 193
Cdd:cd15125  82 TSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLkaIAIWVVSVLLAVPEAVFSEVAHIMPDDNTT 151
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
43-176 1.63e-09

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 58.49  E-value: 1.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15064   2 LISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGR---WILGQVLCDIWIS 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYI--WAHAVVASVP 176
Cdd:cd15064  79 LDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIAlvWTLSICISLP 134
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
43-329 1.88e-09

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 58.64  E-value: 1.88e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFdiiLSTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd15094   2 ISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECF-LIGLPF---LIVTMILKYWPFGAAMCKIYMV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSL 200
Cdd:cd15094  78 LTSINQFTSSFTLTVMSADRYLAVCHPIRsmRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 ---GHLVYVLvYNITTVIVPVvvvfLFLILIRRALsasqkkkvIIAALRT--PQNTISIPYASQReaELHATLLSMVMVF 275
Cdd:cd15094 158 avnGQKAFTL-YTFLLGFAIP----LLLISVFYTL--------VILRLRTvgPKNKSKEKRRSHR--KVTRLVLTVISVY 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  276 ILCSVPY----ATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15094 223 IICWLPYwafqVHLIFLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
50-329 2.23e-09

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 58.13  E-value: 2.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIG-SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSphCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15053   8 LLLPLlTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVN--GGKWYLGPILCDIYIAMDVMCS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAVTNVADIYATSTCteVWSNSlghlvYV 206
Cdd:cd15053  86 TASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTiaIVWVVSAAIACPLLFGLNNVPYRDPEEC--RFYNP-----DF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  207 LVYNITTVIVPVVVVFLFL-ILIRRALsasqkkkviiaalrtpqntisipyasQREAELHATLLSMVMVFILCSVPYATL 285
Cdd:cd15053 159 IIYSSISSFYIPCIVMLLLyYRIFRAL--------------------------RREKKATKTLAIVLGVFLFCWLPFFTL 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  286 VVYQTV---LNVPDTSVFLLLT--AVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15053 213 NILNAIcpkLQNQSCHVGPALFslTTWLGYVNSFLNPIIYTIFNIEFRK 261
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
50-196 2.45e-09

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 58.29  E-value: 2.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15979   9 VIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGT---FIFGEVICKAVAYLMGVSVS 85
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSR--ELVMYIWAHAVVASVP--VFAVT---NVADIYATSTCTEVW 196
Cdd:cd15979  86 VSTFSLVAIAIERYSAICNPLQSRVWQTRSHayRVIAATWLLSGLIMIPypVYSVTvpvPVGDRPRGHQCRHAW 159
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
42-287 4.62e-09

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 57.71  E-value: 4.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   42 QFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSV-TNRFIKNLACSGICASLVCVPFDIIlstsphccW-----WIYTML 115
Cdd:cd15382   1 LVSIIVYSVLFLIAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTFIMMPLEIG--------WaatvaWLAGDF 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  116 FCKVVKFLhKVFC---SVTILSfpAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVP---VFAVTNVADIYAT 189
Cdd:cd15382  73 LCRLMLFF-RAFGlylSSFVLV--CISLDRYFAILKPLRLSDARRRGRIMLAVAWVISFLCSIPqsfIFHVESHPCVTWF 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  190 STCteVWSNSLGHLVYVLVYNITTVIVPVVVVFLF------LILIRRALSASQKKKVIIAAL------RTPQNTISipYA 257
Cdd:cd15382 150 SQC--VTFNFFPSHDHELAYNIFNMITMYALPLIIivfcysLILCEISRKSKEKKEDVSEKSssvrlrRSSVGLLE--RA 225
                       250       260       270
                ....*....|....*....|....*....|
gi 6005772  258 SQReaELHATLLsMVMVFILCSVPYATLVV 287
Cdd:cd15382 226 RSR--TLKMTIV-IVLVFIICWTPYFIMSL 252
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
49-178 6.17e-09

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 57.42  E-value: 6.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGS--LLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPfdIILSTSPHcCWWIYTMLFCKVVKFLHKV 126
Cdd:cd15336   6 VILIIGItgMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSP--IFFVNSLH-KRWIFGEKGCELYAFCGAL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVF 178
Cdd:cd15336  83 FGITSMITLLAISLDRYLVITKPLAsiRWVSKKRAMIIILLVWLYSLAWSLPPL 136
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
50-180 6.45e-09

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 57.07  E-value: 6.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15012   8 LVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPS---WPFGEVLCRMYQFVHSLSYT 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVFAV 180
Cdd:cd15012  85 ASIGILVVISVERYIAILHPLRCKqlLTAARLRVTIVTVWLTSAVYNTPYFVF 137
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
49-331 6.78e-09

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 56.93  E-value: 6.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASlVCVPFDiilSTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15090   8 SIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT-STLPFQ---SVNYLMGTWPFGNILCKIVISIDYYNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLE----RKISDAKSRELVMYIWAHAVvaSVPVFAVTNVADIYATSTCTEV-------WS 197
Cdd:cd15090  84 FTSIFTLCTMSVDRYIAVCHPVKaldfRTPRNAKIVNVCNWILSSAI--GLPVMFMATTKYRQGSIDCTLTfshpswyWE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLGHLVYVLVynittvivpvvvvFLFLILIRRALSAsqkkkVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFIL 277
Cdd:cd15090 162 NLLKICVFIFA-------------FIMPVLIITVCYG-----LMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIV 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  278 CSVPYATLVVYQTVLNVPDTsvfLLLTAVWLPKVSL-----LANPVLFLTVNKSVRKCL 331
Cdd:cd15090 224 CWTPIHIYVIIKALVTIPET---TFQTVSWHFCIALgytnsCLNPVLYAFLDENFKRCF 279
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
51-208 6.80e-09

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 57.07  E-value: 6.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFDIILSTSPhccwWIYTMLFCKVVKFLHKVFCSV 130
Cdd:cd15174  10 IFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLF-LCTLPFWATAASSG----WVFGTFLCKVVNSMYKINFYS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  131 TILSFPAIALDRYYSVLYPLERKISDAK----SRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVYV 206
Cdd:cd15174  85 CMLLLTCISVDRYIAIVQATKAHNSKNKrllySKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESNRFKV 164

                ..
gi 6005772  207 LV 208
Cdd:cd15174 165 AV 166
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
47-175 6.82e-09

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 56.84  E-value: 6.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFI-GSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTsphCCWWIYTMLFCKVVKFLHK 125
Cdd:cd15327   5 VFLAIFIlMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEV---LGFWAFGRVFCDIWAAVDV 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASV 175
Cdd:cd15327  82 LCCTASILSLCVISVDRYVGVKHSLKYPtiMTERKAGVILVLLWVSSMVISI 133
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
50-162 7.06e-09

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 56.80  E-value: 7.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15978   9 LIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKD---FIFGSAVCKTATYFMGISVS 85
                        90       100       110
                ....*....|....*....|....*....|...
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSREL 162
Cdd:cd15978  86 VSTFNLVAISLERYSAICKPLKSRVWQTKSHAL 118
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
49-320 9.08e-09

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 56.69  E-value: 9.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLhKVFC 128
Cdd:cd15058   8 ALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGK---WQLGNFWCELWTSV-DVLC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 -SVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWA-HAVVASVPV----FAVTNVADI--YATSTCTEVWSN 198
Cdd:cd15058  84 vTASIETLCVIAVDRYIAITRPLRYQvlLTKRRARVIVCVVWIvSALVSFVPImnqwWRANDPEANdcYQDPTCCDFRTN 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  199 S------------LGHLVYVLVYNIttvivpvvvvfLFLILIRRALSASQKKKVIIAALRTPQNTISIPYAS--QREAEL 264
Cdd:cd15058 164 MayaiassvvsfyIPLLIMIFVYAR-----------VFLIATRQLQLIDKRRLRFQSECPAPQTTSPEGKRSsgRRPSRL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  265 HAT-------LLSMVM-VFILCSVPYATLVVYQTV-LNVPDTSVFLLLTavWLPKVSLLANPVLF 320
Cdd:cd15058 233 TVVkehkalkTLGIIMgTFTLCWLPFFIANIINVFnRNLPPGEVFLLLN--WLGYINSGLNPIIY 295
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
55-175 9.72e-09

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 56.44  E-value: 9.72e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   55 SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTsphCCWWIYTMLFCKVVKFLHKVFCSVTILS 134
Cdd:cd15326  14 AIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEI---LGYWVFGRIFCDIWAAVDVLCCTASILS 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6005772  135 FPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASV 175
Cdd:cd15326  91 LCAISIDRYIGVRHSLQYPTIVTRKRAILalLGVWVLSTVISI 133
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
49-329 1.04e-08

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 56.54  E-value: 1.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIgSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15048   9 VLILV-TVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGK---WPFGKVFCKAWLVVDYTLC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLY-PLERKISDAKSRELVMYI-WAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVYV 206
Cdd:cd15048  85 TASALTIVLISLDRYLSVTKaVKYRAKQTKRRTVLLMALvWILAFLLYGPAIIGWDLWTGYSIVPTGDCEVEFFDHFYFT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  207 LVYNITTVIVPVVVVFLFLILI-----RRALSASQKKKVIIAALRTPQNTISIPyaSQREAELH---ATLLSM-VMVFIL 277
Cdd:cd15048 165 FITSVLEFFIPFISVSFFNLLIylnirKRSRRRPLRSVPILPASQNPSRARSQR--EQVKLRRDrkaAKSLAIlVLVFLI 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  278 CSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15048 243 CWAPYTILTIIRSFCSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
51-178 1.08e-08

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 56.32  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilsTSPHCCWWIYTMLFCKVVKFLHKVFCSV 130
Cdd:cd15398  10 ISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTL---TCVLLDQWIFGEVMCHIVPFLQCVSVMV 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6005772  131 TILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIW--AHAVVASVPVF 178
Cdd:cd15398  87 STLMLMSIAIVRYHMIKHPLSNHLTANHGYFLLGTVWtlGFTICSPLPVF 136
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
47-320 1.09e-08

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 56.35  E-value: 1.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFdiiLSTSPHCCWWIYTMLFCKVVKFLHKV 126
Cdd:cd15974   6 IYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFML-GLPF---LATQNAISYWPFGSFLCRLVMTVDGV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLE----RKISDAKSreLVMYIWAHAVVASVPVFAVTNVADIYATSTCT-----EVWS 197
Cdd:cd15974  82 NQFTSIFCLTVMSIDRYLAVVHPIKstkwRRPRVAKL--INATVWTLSFLVVLPVIIFSDVQPDLNTCNISwpepvSVWS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLghLVYVLVYNITTVIVPVVVVFLFLILirralsasqkkKVIIAALRtpqntisIPYASQREAELHAT--LLSMVMVF 275
Cdd:cd15974 160 TAF--IIYTAVLGFFGPLLVICLCYLLIVI-----------KVKSSGLR-------VGSTKRRKSERKVTrmVVIIVVVF 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6005772  276 ILCSVPYATLVVYQTVLNVPDTSVF--LLLTAVWLPKVSLLANPVLF 320
Cdd:cd15974 220 VFCWLPFYMLNIVNLIVILPEEPAFvgVYFFVVVLSYANSCANPILY 266
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
50-185 1.18e-08

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 56.36  E-value: 1.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15395  10 VIILG-VSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMCLPFTFVYTLMDH---WVFGEAMCKLNSMVQCISIT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVAD 185
Cdd:cd15395  86 VSIFSLVLIAIERHQLIINPRGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFQVLTD 141
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
49-328 1.55e-08

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 55.88  E-value: 1.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMV---LWSTCRTTVfKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHK 125
Cdd:cd15002   7 GVICLLGFAGNLMVigiLLNNARKGK-PSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGS---WPLGWFVCKTADWFGH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPL-ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSnSLGH-- 202
Cdd:cd15002  83 ACMAAKSFTIAVLAKACYMYVVNPTkQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIP-PLAHef 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 -LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKviiaalRTPQNTIsipyasqREAELHATLLSMVMVFILCSVP 281
Cdd:cd15002 162 mSAFVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKT------QNLRNQI-------RSRKLTHMLLSVVLAFTILWLP 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 6005772  282 YATLVVY---QTVLNVPDTSVFLLLTAVWLPKVSlLANPVLFLTVNKSVR 328
Cdd:cd15002 229 EWVAWLWlihIKSSGSSPPQLFNVLAQLLAFSIS-SVNPIIFLLMSEEFR 277
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
49-320 1.83e-08

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 55.69  E-value: 1.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFdiiLSTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15970   9 VVCLVG-LCGNSMVIYVILRYAKMKTATNIYILNLAIADELLML-SVPF---LVTSTLLRHWPFGSLLCRLVLSVDAINM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLE----RKISDAKSRELVMYIWAHAVVASVPVFAVTnVADIYATSTCTEVWSNSLGHLV 204
Cdd:cd15970  84 FTSIYCLTVLSIDRYIAVVHPIKaaryRRPTVAKMVNLGVWVFSILVILPIIIFSNT-APNSDGSVACNMQMPEPSQRWL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNITTVIVPVVVVFLFLILIrralsasqkkkVIIAALRTPqnTISIPYASQREAELHATLLSM--VMVFILCSVPY 282
Cdd:cd15970 163 AVFVVYTFLMGFLLPVIAICLCYI-----------LIIVKMRVV--ALKAGWQQRKRSERKITLMVMmvVTVFVICWMPF 229
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6005772  283 ATLVVYQTVLNVPDTSVFLLltAVWLPKVSLLANPVLF 320
Cdd:cd15970 230 YVVQLVSVFVGQHDATVSQL--SVILGYANSCANPILY 265
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
46-176 1.88e-08

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 55.70  E-value: 1.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDiilSTSPHCCWWIYTMLFCKVVKFLHK 125
Cdd:cd15123   6 TYAVIISVG-ILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTCVPVD---ATRYIADTWLFGRIGCKLLSFIQL 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMY--IWAHAVVASVP 176
Cdd:cd15123  82 TSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAgcVWIVSMLFAIP 134
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
45-177 1.94e-08

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 55.68  E-value: 1.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd15958   4 SLLMALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGR---WLYGSFFCELWTSVD 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWA-HAVVASVPV 177
Cdd:cd15958  81 VLCVTASIETLCVIAIDRYLAITSPFRYQslLTRARAKGIVCTVWAiSALVSFLPI 136
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
44-329 2.68e-08

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 55.30  E-value: 2.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIF--IGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcvPFDIILSTSPHCCWWIyTMLFCKVVK 121
Cdd:cd15402   1 TALACILIFtiVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIY--PYPLVLTSIFHNGWNL-GYLHCQISG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FLHKVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNS 199
Cdd:cd15402  78 FLMGLSVIGSIFNITGIAINRYCYICHSLkyDKLYSDKNSLCYVLLIWVLTVAAIVPNLFVGSLQYDPRIYSCTFAQSVS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGHLVYVLVYNITTVIVPVVVVFL----FLILIRRALSASQKKKViiaalrTPQNTisipyasqreaelhATLLSMVMVF 275
Cdd:cd15402 158 SAYTIAVVFFHFILPIIIVTFCYLriwiLVIQVRRRVKPDNKPKL------KPHDF--------------RNFVTMFVVF 217
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  276 ILCSVPYATL-VVYQTVLNVPDTSV-----FLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15402 218 VLFAVCWAPLnFIGLAVAVDPETIVpripeWLFVASYYMAYFNSCLNAIIYGLLNQNFRR 277
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
50-329 2.96e-08

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 54.98  E-value: 2.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15310   9 ALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGV--WNFSRICCDVFVTLDVMMCT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRE-----LVMYIWAHAVVASVPVFAVTNVADiyATSTCtevwsnSLGHLV 204
Cdd:cd15310  87 ASILNLCAISIDRYTAVVMPVHYQHGTGQSSCrrvslMITAVWVLAFAVSCPLLFGFNTTG--DPTVC------SISNPD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNITTVIVPVVVVFLFLILIRRALSASQKkkviiaalrtpqntisipyASQreaelhatLLSMVM-VFILCSVPYA 283
Cdd:cd15310 159 FVIYSSVVSFYLPFGVTLLVYVRIYVVLLREKK-------------------ATQ--------MLAIVLgAFIVCWLPFF 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6005772  284 TLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15310 212 LTHILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
49-204 2.98e-08

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 54.67  E-value: 2.98e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLL---GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccWWIYTMLFCKVVKFLHK 125
Cdd:cd15067   4 VVLSLFCLVtvaGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGG--YWLFGRDWCDVWHSFDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFA-VTNVADIY-ATSTCteVWSNSLG 201
Cdd:cd15067  82 LASTASILNLCVISLDRYWAITDPIsyPSRMTKRRALIMIALVWICSALISFPAIAwWRAVDPGPsPPNQC--LFTDDSG 159

                ...
gi 6005772  202 HLV 204
Cdd:cd15067 160 YLI 162
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
51-285 3.45e-08

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 55.08  E-value: 3.45e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFdiilstsphccW---------WIYTMLFCKVVK 121
Cdd:cd14985  10 IFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVF-VLTLPL-----------WatytanqydWPFGAFLCKVSS 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FLHKV--FCSVTILSfpAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYAT--STCTEV 195
Cdd:cd14985  78 YVISVnmFASIFLLT--CMSVDRYLAIVHPVAsrRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLnkTACIML 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  196 WSNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSAsqKKKVIIAALRTPQNTISIpyasqreaelhatLLSMVMVF 275
Cdd:cd14985 156 YPHEAWHFGLSLELNILGFVLPLLIILTCYFHIARSLRK--RYERTGKNGRKRRKSLKI-------------IFALVVAF 220
                       250
                ....*....|
gi 6005772  276 ILCSVPYATL 285
Cdd:cd14985 221 LVCWLPFHFF 230
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
49-328 3.47e-08

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 54.55  E-value: 3.47e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15335   8 ALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVAVLVMPLSITYIVMDT---WTLGYFICEIWLSVDMTCC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTeVWSNSLGHLVYv 206
Cdd:cd15335  85 TCSILHLCVIALDRYWAITDAIEyaRKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCI-IQHDHVIYTIY- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  207 lvyniTTVIVPVVVVFLFLILIRRALSASQKkkviiaalrtpqntisipyasQREAelhATLLSMVM-VFILCSVPY--A 283
Cdd:cd15335 163 -----STFGAFYIPLTLILILYYRIYHAASR---------------------ERKA---ARILGLILgAFILSWLPFfiK 213
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 6005772  284 TLVVYQTVLNV-PDTSVFLlltaVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15335 214 ELIVGLSVMTVsPEVADFL----TWLGYVNSLVNPLLYTSFNEDFK 255
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
44-176 4.69e-08

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 54.36  E-value: 4.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFL 123
Cdd:cd15060   3 TTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGK---WLFGIHLCQMWLTC 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMY--IWAHAVVASVP 176
Cdd:cd15060  80 DILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIvvVWALSALISVP 134
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
51-329 6.06e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 53.79  E-value: 6.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilsTSPHCCWWIYTMLFCKVVKFLHKVFCSV 130
Cdd:cd15323  10 LIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSL---ANELMGYWYFGQVWCNIYLALDVLFCTS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  131 TILSFPAIALDRYYSVLYPLERKISDAKSR--ELVMYIW-AHAVVASVPVFAVTNVADIYATSTCT---EVW---SNSLG 201
Cdd:cd15323  87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRvkAIIVTVWlISAVISFPPLISMYRDPEGDVYPQCKlndETWyilSSCIG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 H-----LVYVLVYnittvivpvvvvflflILIRRALSASQKKKVIIaalrtpqntisipyasqreaelhatlLSMVM-VF 275
Cdd:cd15323 167 SffapcLIMILVY----------------IRIYRVAKAREKRFTFV--------------------------LAVVMgVF 204
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  276 ILCSVP----YATLVVYQTVLNVPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15323 205 VVCWFPfffsYSLYGICREACEVPEP---LFKFFFWIGYCNSSLNPVIYTIFNQDFRR 259
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
50-175 7.26e-08

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 53.65  E-value: 7.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPhccWWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15062   9 AFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLG---YWAFGRIFCDVWAAVDVLCCT 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASV 175
Cdd:cd15062  86 ASIMSLCVISVDRYIGVRYPLNYPtiVTARRATVALLIVWVLSLVISI 133
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
49-191 7.30e-08

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 54.14  E-value: 7.30e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15124   9 IIILIG-LIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADE---WLFGRVGCKLIPFIQLTSV 84
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASVPVFAVTNVADIYATST 191
Cdd:cd15124  85 GVSVFTLTALSADRYKAIVRPMDIQASNALMKICLkaALIWILSMLLAIPEAVFSDLHPFYDKST 149
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
45-176 7.43e-08

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 54.10  E-value: 7.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilstspHCCWWIYTMLF----CKVV 120
Cdd:cd15357   4 SLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFGMPLEV------YEMWSNYPFLFgpvgCYFK 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  121 KFLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSREL--VMYIWAHAVVASVP 176
Cdd:cd15357  78 TALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALkiIVVLWVLSVLFSIP 135
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
58-320 8.79e-08

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 53.76  E-value: 8.79e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   58 GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCSVTILSFPA 137
Cdd:cd15959  17 GNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGH---WPLGTTVCELWTSVDVLCVTASIETLCA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  138 IALDRYYSVLYPL--ERKISDAKSRELVMYIWA-HAVVASVPVF-------AVTNVADIYATSTCTEVWSNslghLVYVL 207
Cdd:cd15959  94 IAVDRYLAITNPLryEALVTKRRARTAVCLVWAiSAAISFLPIMnqwwrdgADEEAQRCYDNPRCCDFVTN----MPYAI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  208 VYNITTVIV-PVVVVFLF---LILIRRALSASQKKKVIIAALRTPQNTiSIPYASQREAEL-----HATL--LSMVM-VF 275
Cdd:cd15959 170 VSSTVSFYVpLLVMIFVYvrvFVVATRQVRLIRKDKVRFPPEESPPAE-SRPACGRRPSRLlaikeHKALktLGIIMgTF 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6005772  276 ILCSVPYATLVVYQTVLN--VPDtSVFLLLTavWLPKVSLLANPVLF 320
Cdd:cd15959 249 TLCWLPFFVANIIKVFCRslVPD-PAFLFLN--WLGYANSAFNPIIY 292
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
47-335 9.11e-08

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 53.42  E-value: 9.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIL-------STSPHCCWWIYtmlfckv 119
Cdd:cd15307   6 LALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTlvkghfpLSSEHCLTWIC------- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  120 vkfLHKVFCSVTILSFPAIALDRYYSVLYPLerKISDAKSRELV----MYIWAHAVVASVP--VFAVTNVADIYATSTCt 193
Cdd:cd15307  79 ---LDVLFCTASIMHLCTISVDRYLSLRYPM--RFGRNKTRRRVtlkiVFVWLLSIAMSLPlsLMYSKDHASVLVNGTC- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  194 evwsnSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALrtpqntisipyasqrEAELHATLLSMVM 273
Cdd:cd15307 153 -----QIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRIIRL---------------EQKATKVLGVVFF 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  274 VFILCSVPYATLVVYQTVLNVPDTSV--FLLLTAVWLPKVSLLANPVLFLTVNKSVRKCLIGTL 335
Cdd:cd15307 213 TFVILWSPFFVLNLLPTVCAECEERIshWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 276
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
55-330 9.65e-08

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 53.32  E-value: 9.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   55 SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPfdIILSTSPHCCWWIYTMlFCKVVKFLHKVFCSVTILS 134
Cdd:cd15085  14 SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTT--IVTVTNYEGYFYLGDA-FCIFQGFAVNYFGIVSLWS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  135 FPAIALDRYYSVLYPLER-KISDAKSRELVMYIWAHAVV-ASVPVFAVTNVADIYATSTCTEVWSN-SLGHLVYVLVYni 211
Cdd:cd15085  91 LTLLAYERYNVVCKPMGGlKLSTKRGYQGLLFIWLFCLFwAVAPLFGWSSYGPEGVQTSCSIGWEErSWSNYSYLILY-- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  212 ttvivpvvvvFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHAT--LLSMVMVFILCSVPY---ATLV 286
Cdd:cd15085 169 ----------FLMCFVIPVAIIGFSYGNVLRSLHKLNKKIEQQGGKNCPEEEERAVimVLAMVIAFLICWLPYtvfALIV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6005772  287 VYQTVLNVPDTSVFLlltAVWLPKVSLLANPVLFLTVNKSVRKC 330
Cdd:cd15085 239 VVNPELSISPLAATM---PTYFAKTSPVYNPIIYIFLNKQFRES 279
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
47-328 9.72e-08

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 53.79  E-value: 9.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSvTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTM--LFCKVVKFLH 124
Cdd:cd14978   6 VLPVICIFGIIGNILNLVVLTRKSMRSS-TNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFyaYFLPYIYPLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVF--CSVTILSfpAIALDRYYSVLYPLERKI--SDAKSRELVMYIWAHAVVASVPVF----AVTNVADIYATSTCTEVW 196
Cdd:cd14978  85 NTFqtASVWLTV--ALTVERYIAVCHPLKARTwcTPRRARRVILIIIIFSLLLNLPRFfeyeVVECENCNNNSYYYVIPT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVYVLVYNITTVIVPVVVVFLFL----ILIRRALSASQKKKVIIAALRTPQNTisipyASQREAELHATLLSMV 272
Cdd:cd14978 163 LLRQNETYLLKYYFWLYAIFVVLLPFILLlilnILLIRALRKSKKRRRLLRRRRRLLSR-----SQRRERRTTIMLIAVV 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  273 MVFILCSVPYATLVVYQTVLNVPDTS-VFLLLTAVwlpkvsllANpvLFLTVNKSVR 328
Cdd:cd14978 238 IVFLICNLPAGILNILEAIFGESFLSpIYQLLGDI--------SN--LLVVLNSAVN 284
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
45-331 9.72e-08

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 53.42  E-value: 9.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASlVCVPFDiilSTSPHCCWWIYTMLFCKVVKFLH 124
Cdd:cd15091   4 TAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVT-TTMPFQ---STVYLMNSWPFGDVLCKIVISID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLE----RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCT------- 193
Cdd:cd15091  80 YYNMFTSIFTLTMMSVDRYIAVCHPVKaldfRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSlqfpddd 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  194 -EVWSNSLGHLVYVLVYNITTVIVPVVVVFLFLILIR-RALSASQKKkviiaalrtpqntisipyaSQREAELHATLLSM 271
Cdd:cd15091 160 ySWWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLKSvRLLSGSREK-------------------DRNLRRITRLVLVV 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  272 VMVFILCSVPYATLVVYQTVLNVPDT----SVFLLLTAVWLPKVSLlaNPVLFLTVNKSVRKCL 331
Cdd:cd15091 221 VAVFVVCWTPIHIFILVEALGSVSHStaavSSYYFCIALGYTNSSL--NPILYAFLDENFKRCF 282
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
44-183 1.04e-07

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 53.49  E-value: 1.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCcwWIYTMLFCKVVKFL 123
Cdd:cd15134   3 ITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYTIWQQYP--WVFGEVFCKLRAFL 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSR--ELVMYIWAHAVVASVPVFAVTNV 183
Cdd:cd15134  81 SEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRaiRIIIAIWIIAFVCALPFAIQTRI 142
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
56-331 1.55e-07

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 52.94  E-value: 1.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   56 LLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTspHCCWWiYTMLFCKVVKFLHKVFCSVTILSF 135
Cdd:cd15318  15 VLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSV--ESCWY-FGDSFCRLHTCLDTLFCLTSIFHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  136 PAIALDRYYSVLYPLeRKISDAKSRELVMYIWAHAVVASV--PVFAVTNVADIYATSTCTEVWSNSLGHLVYVLVYNITT 213
Cdd:cd15318  92 CFISIDRHCAICDPL-LYPSKFTIRVACIFIAAGWLVPTVytSVFLYTKAVEEGLAELLTSVPCVGSCQLLYNKLWGWLN 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  214 VIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTisipyASQREAELHATLLSMVMVFILCSVPYATLVVYQTVLN 293
Cdd:cd15318 171 FPVFFIPCLIMIGLYVKIFIVAKRQARAIASLLSDTNG-----ASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLN 245
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6005772  294 VPdTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15318 246 FI-TPPLLFDIIIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
56-320 1.56e-07

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 52.83  E-value: 1.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   56 LLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIlsTSPHCCWWiYTMLFCKVVKFLHKVFCSVTILSF 135
Cdd:cd15317  15 VSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMI--RTVETCWY-FGDLFCKFHTGLDLLLCTTSIFHL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  136 PAIALDRYYSVLYPLeRKISDAKSRELVMYIWAHAVVASVPVFAVtnvadIY--ATSTCTEVWSNSLG-----HLVYVLV 208
Cdd:cd15317  92 CFIAIDRYYAVCDPL-RYPSKITVQVAWRFIAIGWLVPGIYTFGL-----IYtgANDEGLEEYSSEIScvggcQLLFNKI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  209 YNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTI---SIPYASQREAELHATLLSMVMVFILCSVPYATL 285
Cdd:cd15317 166 WVLLDFLTFFIPCLIMIGLYAKIFLVARRQARKIQNMEDKFRSSeenSSKASASRERKAAKTLAIVMGIFLFCWLPYFID 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 6005772  286 VVYQTVLNVpDTSVFLLLTAVWLPKVSLLANPVLF 320
Cdd:cd15317 246 TIVDEYSNF-ITPAIVFDAVIWLGYFNSAFNPFIY 279
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
47-176 1.60e-07

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 53.14  E-value: 1.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFK-SVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLhK 125
Cdd:cd15383   6 VTFVLFVLSACSNLAVLWSATRNRRRKlSHVRILILHLAAADLLVTFVVMPLDAAWNVTVQ---WYAGDLACRLLMFL-K 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  126 VFCS-----VTILsfpaIALDRYYSVLYPLErkISDAKSRELVMYI--WAHAVVASVP 176
Cdd:cd15383  82 LFAMyssafVTVV----ISLDRHAAILNPLA--IGSARRRNRIMLCaaWGLSALLALP 133
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
42-290 2.03e-07

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 52.60  E-value: 2.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   42 QFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICasLVC-VPFdiilstsphccW-------WIYT 113
Cdd:cd14984   1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLL--FVLtLPF-----------WavyaadgWVFG 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  114 MLFCKVVKFLHKV--FCSVTILSFpaIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYAT 189
Cdd:cd14984  68 SFLCKLVSALYTInfYSGILFLAC--ISIDRYLAIVHAVSalRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGS 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  190 STCTEVWSNSLGHLVYVLVynittvivPVVVVFLFLIL-----------IRRALSASQKK------KVIIAalrtpqnti 252
Cdd:cd14984 146 SICSYDYPEDTATTWKTLL--------RLLQNILGFLLpllvmlfcysrIIRTLLRARNHkkhralRVIFA--------- 208
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 6005772  253 sipyasqreaelhatllsMVMVFILCSVPYATLVVYQT 290
Cdd:cd14984 209 ------------------VVVVFFLCWLPYNIVLLLDT 228
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-176 2.17e-07

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 52.60  E-value: 2.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPfdiILSTSPHCCWWIYTMLFCKVVKFL 123
Cdd:cd15977   3 NTILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIAIP---INVIKLIAEDWPFGVHVCKLYPFI 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERK---ISDAKSRELVMyIWAHAVVASVP 176
Cdd:cd15977  80 QKASVGITVLSLCALSIDRYRAVASWSRIRgigIPVWKAVEVTL-IWAVAIIVAVP 134
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
49-331 2.17e-07

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 52.32  E-value: 2.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcASLVCVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKV-- 126
Cdd:cd15168   8 GVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDL-LYLLSLPFLIYYYANGDH--WIFGDFMCKLVRFLFYFnl 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFpaIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNslGHLV 204
Cdd:cd15168  85 YGSILFLTC--ISVHRYLGICHPLRslGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSP--EELN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNITTVIVPVVVVFLFLI----LIRRALSASQKKKVIIAALRTPQNTIsipyasqreaelhatlLSMVMVFILCSV 280
Cdd:cd15168 161 DYVIYSMVLTGLGFLLPLLIILacygLIVRALIRKLGEGVTSALRRKSIRLV----------------IIVLALFAVCFL 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  281 PY---ATLVVYQTVLN-VPDTSVFLLLTA---VWLPKVSLLA--NPVLFLTVNKSVRKCL 331
Cdd:cd15168 225 PFhvtRTINLAARLLSgTASCATLNGIYVaykVTRPLASLNSclNPLLYFLAGDKFRRRL 284
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
49-329 2.19e-07

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 52.43  E-value: 2.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWS-TCRTTVFKSVTNRFIKNLACSGICASLVCVPFDiilSTSPHCCWWIYTMlFCKVVKFLHKVF 127
Cdd:cd15057   8 YLLVLLTLLGNALVIAAvLRFRHLRSKVTNYFIVSLAVSDLLVAILVMPWA---AVNEVAGYWPFGS-FCDVWVSFDIMC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  128 CSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVAS-VPVFAVTNVAD-------IYATSTCTEVWS 197
Cdd:cd15057  84 STASILNLCVISVDRYWAISSPFryERRMTRRRAFIMIAVAWTLSALISfIPVQLGWHRADdtsealaLYADPCQCDSSL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLGHLVYVLVynittviVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIP-----YASQREAELHATLLSMV 272
Cdd:cd15057 164 NRTYAISSSLI-------SFYIPVAIMIVTYTRIYRIARRQIRRIAALERAAQESTNPdsslrSSLRRETKALKTLSIIM 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  273 MVFILCSVPYATL--------VVYQTVLNVPDTsVFLLLtaVWLPKVSLLANPVLFLTvNKSVRK 329
Cdd:cd15057 237 GVFVCCWLPFFILncvlpfcdLRTAQFPCVPDT-TFIVF--VWLGWANSSLNPIIYAF-NADFRK 297
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
47-286 2.55e-07

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 52.23  E-value: 2.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICasLVC-VPFDIILSTSPHccwWIYTMLFCKV--VKFL 123
Cdd:cd15155   6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLL--FVFtLPFKIFYNFNRH---WPFGDSLCKIsgTAFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSfpAIALDRYYSVLYPLE-RKISDAKSRELVMY-IWAHAVVA--SVPVFAVTNVADiyATSTCTEVWSNS 199
Cdd:cd15155  81 TNIYGSMLFLT--CISVDRFLAIVYPFRsRTIRTRRNSAIVCAgVWILVLSGgiSASLFSTTNVSN--TSTTCFEGFSKS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGHlvyvlVYNITTVIVPVVVVFLFLILIRRALSAsqkkkviiAALRTPQNTISIPYASQREAELHATLLSMVMVFILCS 279
Cdd:cd15155 157 IWK-----TYLSKITIFIEVVGFIIPLLLNLTCSS--------LVLRTLRKPATLSQIGTNKEKVLKMILVHVAIFVVCF 223

                ....*..
gi 6005772  280 VPYATLV 286
Cdd:cd15155 224 VPYNSIL 230
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
49-185 2.77e-07

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 51.76  E-value: 2.77e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPfdIILSTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15308   8 VLLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLP--LYVYSEFQGGVWTLSPVLCDALMTMDVMLC 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM----YIWAHAVVASVpVFAVTNVAD 185
Cdd:cd15308  86 TASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLisatWILSFAVASPV-IFGLNNVPN 145
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
45-331 2.90e-07

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 51.87  E-value: 2.90e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASlVCVPFDiilSTSPHCCWWIYTMLFCKVVKFLH 124
Cdd:cd15089   4 TALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALAT-STLPFQ---SAKYLMETWPFGELLCKAVLSID 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLE----RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADiYATSTCTEVWSNSL 200
Cdd:cd15089  80 YYNMFTSIFTLTMMSVDRYIAVCHPVKaldfRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPR-DGAVVCMLQFPSPS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 GHlvyvlvYNITTVIVPVVVVFLFLILIRRALSAsqkkkVIIAALRTPQNtISIPYASQRE-AELHATLLSMVMVFILCS 279
Cdd:cd15089 159 WY------WDTVTKICVFIFAFVVPILVITVCYG-----LMILRLRSVRL-LSGSKEKDRNlRRITRMVLVVVAAFIICW 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  280 VPYATLVVYQTVLNVPDTSvfLLLTAVWLPKVSL-----LANPVLFLTVNKSVRKCL 331
Cdd:cd15089 227 TPIHIFVIVWTLVDIDRRN--PLVVAALHLCIALgyansSLNPVLYAFLDENFKRCF 281
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
49-320 3.38e-07

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 51.78  E-value: 3.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFdiiLSTSPHCCWWIYTMLFCKVV------KF 122
Cdd:cd15973   9 LVCLVG-LIGNSMVIFVILRYAKMKTATNIYILNLAIADELFML-SVPF---LAASAALQHWPFGSAMCRTVlsvdgiNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCsVTILSfpaiaLDRYYSVLYPLE----RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATStCTEVW-- 196
Cdd:cd15973  84 FTSVFC-LTVLS-----VDRYIAVVHPLRaaryRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVA-CNLIWph 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 -SNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSA----SQKKKviiaalrtpqntisipyasqREAELHATLLSM 271
Cdd:cd15973 157 pAWSAAFVIYTFLLGFLLPVLAIGLCYILIIGKMRAVALkagwQQRRK--------------------SEKKITRMVLMV 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  272 VMVFILCSVPYATLVVYQTVLNVPDTSVFLLltAVWLPKVSLLANPVLF 320
Cdd:cd15973 217 VTVFVICWMPFYVVQLLNLFLPRLDATVNHA--SLILSYANSCANPILY 263
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-328 4.24e-07

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 51.16  E-value: 4.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIlsTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15052   8 LLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPLSIL--TELFGGVWPLPLVLCLLWVTLDVLFC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLerKISDAKSRELVM----YIWAHAVVASVP--VFAVTNVADIYATSTCTevwsnsLGH 202
Cdd:cd15052  86 TASIMHLCTISLDRYMAIRYPL--RTRRNKSRTTVFlkiaIVWLISIGISSPipVLGIIDTTNVLNNGTCV------LFN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 LVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKkkviiaalrtpqntisipyASQreaelhaTLLSMVMVFILCSVPY 282
Cdd:cd15052 158 PNFVIYGSIVAFFIPLLIMVVTYALTIRLLSNEQK-------------------ASK-------VLGIVFAVFVICWCPF 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 6005772  283 ATLVVYQTVLNVPDTSV--FLLLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15052 212 FITNILTGLCEECNCRIspWLLSVFVWLGYVSSTINPIIYTIFNKTFR 259
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
43-329 4.50e-07

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 51.12  E-value: 4.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15329   2 LIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGY---WPFGEILCDVWIS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYI--WAHAVVASV-PVFAVTNvaDIYATSTCTevWSNS 199
Cdd:cd15329  79 FDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAivWLLSALISIpPLFGWKN--KVNDPGVCQ--VSQD 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGHLVYvlvynittvivpvvvvflflilirralsasqkkkVIIAALRTPQNTISIPY-----ASQREAELHATLLSMVMV 274
Cdd:cd15329 155 FGYQIY----------------------------------ATFGAFYIPLIVMLVLYykiyrAAKSERKAIKTLGIIMGA 200
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  275 FILCSVPYATLVVYQTVLNVPDTSVF---LLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15329 201 FTLCWLPFFILALLRPFLKPIKCSCIplwLSRLFLWLGYANSFLNPIIYAKFNREFRT 258
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
55-176 5.13e-07

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 51.10  E-value: 5.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   55 SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilsTSPHCCWWIYTMLFCKVVKFLHKVFCSVTILS 134
Cdd:cd15322  14 TVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSL---ANEVMGYWYFGKVWCEIYLALDVLFCTSSIVH 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 6005772  135 FPAIALDRYYSVLYPLERKISDAKSR--ELVMYIWAHAVVASVP 176
Cdd:cd15322  91 LCAISLDRYWSITQAIEYNLKRTPRRikCIIFIVWVISAVISFP 134
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
47-181 5.17e-07

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 51.02  E-value: 5.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilsTSPHCCWWIYTMLFCKVVKFLHKV 126
Cdd:cd15324   6 VVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSL---ANEVMGYWYFGSTWCAFYLALDVL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVT 181
Cdd:cd15324  83 FCTSSIVHLCAISLDRYWSVTKAVSynLKRTPKRIKRMIAVVWVISAVISFPPLLMT 139
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
43-281 5.38e-07

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 51.29  E-value: 5.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICaSLVCVPFDIilSTSPHCCWWIYTMLFCKVVK- 121
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLL-LVIWLPFKI--AYHIHGNNWIFGEALCRLVTv 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 -FLHKVFCSvtILSFPAIALDRYYSVLYPLERKISDAKSRELV--MYIWAHAVVASVPVFAVTNVADIYAT--STCTEV- 195
Cdd:cd15162  79 aFYGNMYCS--ILLLTCISIDRYLAIVHPMGHRRLRARRYALGtcLAIWLLALLVTLPLYLVKQTIFLPALdiTTCHDVl 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  196 -WSNSLGHLVYVLVynittvivpvvVVFLFLILIRRALSASqkkkVIIAALRTPQNTISIPYASQREAELHATLLSMVMv 274
Cdd:cd15162 157 pEQLLVGDWFYYFL-----------SLAIVGFLIPFILTAS----CYVATIRTLAALEDENSEKKKKRAIKLAATVLAI- 220

                ....*..
gi 6005772  275 FILCSVP 281
Cdd:cd15162 221 FIICFAP 227
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
43-329 6.51e-07

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 50.69  E-value: 6.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIgSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilsTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd15321   9 IAAAITFLILF-TIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSL---ANELMGYWYFRKTWCEIYLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVP--VFAVTNVADIYATSTCT---EV 195
Cdd:cd15321  85 LDVLFCTSSIVHLCAISLDRYWSVSRAIEynSKRTPRRIKCIILIVWLIAAVISLPplIYKGKQKDEQGGLPQCKlneEA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  196 WsnslghlvYVLvynittviVPVVVVFLFLILIrralsasqkkkVIIAALRTPQntisipYASQREAELHATLLSMVMVF 275
Cdd:cd15321 165 W--------YIL--------SSSIGSFFAPCLI-----------MILVYLRIYL------IAKNREKRFTFVLAVVIGVF 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  276 ILCSVP----YATLVVYQTVLNVPDtSVFLLLtaVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15321 212 VLCWFPfffsYSLGAICPELCKVPH-SLFQFF--FWIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
49-307 6.80e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 51.09  E-value: 6.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVF--KSVTNRFIKNLACSGICASLVCVPfdIILSTSPHCCWWIYTMLFCKVVKFLHKV 126
Cdd:cd14981   8 ALMFVFGVLGNLLALIVLARSSKShkWSVFYRLVAGLAITDLLGILLTSP--VVLAVYASNFEWDGGQPLCDYFGFMMSF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 F--CSVTILSfpAIALDRYYSVLYPLERKISDAKSRELVMY--IWAHA-VVASVPVFAVTNVADIYATSTC-TEVWSNSL 200
Cdd:cd14981  86 FglSSLLIVC--AMAVERFLAITHPFFYNSHVKKRRARLMLgaVWAFAlLIASLPLLGLGSYVLQYPGTWCfLDFYSKNT 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 GHLVYVLVYNITTVIVPVVVVFLFLILIrRALSASQKKKVIIAALRTPQntisipyASQREAELH--ATLLSMVMVFILC 278
Cdd:cd14981 164 GDAAYAYLYSILGLLILLVTLLCNLLVI-ITLLRMRRRKKRHRRSRRSA-------RRQKRNEIQmvVLLLAITVVFSVC 235
                       250       260       270
                ....*....|....*....|....*....|..
gi 6005772  279 SVPYATLVVYQTVLNVPDTSVFLLLT---AVW 307
Cdd:cd14981 236 WLPLMIRVLINATGDSEKNGKTDLLAvrmASW 267
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
49-192 9.07e-07

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 50.67  E-value: 9.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15305   8 LIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYA--WPLPRYLCPIWISLDVLFS 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAKSREL--VMYIWAHAVVAS--VPVFAVTNVADIYATSTC 192
Cdd:cd15305  86 TASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMmkIAAVWTISIGISmpIPVIGLQDDEKVFVNGTC 153
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
49-331 1.01e-06

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 50.14  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTnrFIKNLACSGICASLVCVPFDIiLSTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15220   7 VLLDLTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLMPLGI-LSSSPFFLGVVFGEAECRVYIFLSVCLV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAV-VASVPVFA--VTNVADIYATSTCTEVWSNSLGHL 203
Cdd:cd15220  84 SASILTISAISVERYYYIVHPMryEVKMTIGLVAAVLVGVWVKALlLGLLPVLGwpSYGGPAPIAARHCSLHWSHSGHRG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVYNITTVIVPVVVVFLFLILIRRALSASQkkkviiAALrtpqntisipyasqreaelhaTLLSMVMVFILCSVPYA 283
Cdd:cd15220 164 VFVVLFALVCFLLPLLLILVVYCGVFKVFGGGK------AAL---------------------TLAAIVGQFLCCWLPYF 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 6005772  284 TLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15220 217 AFHLYSALAASPVSGGEAEEVVTWLAYSCFAVNPFFYGLLNRQIREEL 264
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
56-208 1.18e-06

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 50.17  E-value: 1.18e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   56 LLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCSVTILSF 135
Cdd:cd14975  15 LPGNSFVIWSILIKVKQRSVTMLLVLNLALADL-AVLLTLPVWIYFLATGT---WDFGLAACKGCVYVCAVSMYASVFLI 90
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  136 PAIALDRYYSVLYP--LERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVwSNSLGHLVYVLV 208
Cdd:cd14975  91 TLMSLERFLAVSRPfvSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMCKYR-HYSDGQLVFHLL 164
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
50-282 1.49e-06

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 50.14  E-value: 1.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTN--RFIKNLACSGICAsLVCVPFDIILSTspHCCWWIYTMLFCKVVK--FLHK 125
Cdd:cd15147   9 IIFVLGLIANCYVLWVFARLYPSKKLNEikIFMVNLTIADLLF-LITLPFWIVYYH--NEGNWILPKFLCNVAGclFFIN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSfpAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVP--VFAVTNV--ADIYATSTCTEVWSNs 199
Cdd:cd15147  86 TYCSVAFLG--VISYNRYQAVTRPIKTAQSTTRKRGIIIsvAIWVIIVASASYflFMDSTNTvkIDSGNFTRCFEGYEK- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 lGHLVYVLVYNittVIVPVVVVFLFLILIRRALsasqkkkVIIAALrtpqntISIPYASQREAELHATLLSMVM----VF 275
Cdd:cd15147 163 -DNSKPVLIIH---FIIIGLFFLVFLLILVCNL-------VIARTL------LSQPVQGQRNAGVKRRALWMVCtvlaVF 225

                ....*..
gi 6005772  276 ILCSVPY 282
Cdd:cd15147 226 VICFVPH 232
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
47-331 1.57e-06

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 49.86  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPF---DIILStsphccWWIYTMLFCKVVKFL 123
Cdd:cd15092   6 VYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLV-LLTLPFqgtDIFLG------FWPFGNALCKTVIAI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 --HKVFCSVTILSfpAIALDRYYSVLYPLE----RKISDAKSRELVmyIWAHAVVASVPVFAVTNVAD-------IYATS 190
Cdd:cd15092  79 dyYNMFTSTFTLT--AMSVDRYVAICHPIKaldvRTPHKAKVVNVC--IWALASVVGVPVMVMGSAQVedeeiecLVEIP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  191 TCTEVWSNSLGHLVYVLVYnittVIVPVVVVFLFLILIR-----RALSASQKKKviiAALRtpqntisipyasqreaELH 265
Cdd:cd15092 155 TPQDYWDPVFGICVFLFSF----IIPVLIISVCYSLMIRrlrgvRLLSGSKEKD---RNLR----------------RIT 211
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  266 ATLLSMVMVFILCSVPYATLVVYQTVLNVP--DTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15092 212 RLVLVVVAVFVGCWTPIQIFVLAQGLGVQPssETAVAILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-176 1.84e-06

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 49.84  E-value: 1.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilstspHCCWWIYTMLF----CKVV 120
Cdd:cd15133   4 CLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLGMPLEL------YELWQNYPFLLgsggCYFK 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  121 KFLHKVFCSVTILSFPAIALDRYYSVLYPLERKI--SDAKSRELVMYIWAHAVVASVP 176
Cdd:cd15133  78 TFLFETVCLASILNVTALSVERYIAVVHPLAARTcsTRPRVTRVLGCVWGVSMLCALP 135
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
47-153 1.91e-06

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 49.46  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWIYTMLFCKVVkflhkV 126
Cdd:cd15071   6 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQTEFYSCLMVACPVL-----I 80
                        90       100
                ....*....|....*....|....*..
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLERK 153
Cdd:cd15071  81 LTQSSILALLAIAVDRYLRVKIPTRYK 107
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
50-288 2.06e-06

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 49.38  E-value: 2.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15154   9 LLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTL-SLPLRIYYYANHY---WPFGNFLCQFSGSIFQMNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLE-RKISDAK-SRELVMYIWAHAVVASVPVFAVTNVADIYA----TSTCTEVWSNSLGHL 203
Cdd:cd15154  85 GSCLFLMCINVDRYLAIVHPLRfRHLRRPKvARLLCLAVWALILGGSVPAAIVHSSSDCLLhgekVYRCFESFSDNDWKG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVynittvivPVVVVFLFLILIRRALSASQKKKVIIAALRTPQntisipyaSQREAELHATLLSMVMVFILCSVPY- 282
Cdd:cd15154 165 LLPLV--------VLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQ--------QGRRRKTVRLLLVNLVIFLICFVPYn 228

                ....*.
gi 6005772  283 ATLVVY 288
Cdd:cd15154 229 TTLAVY 234
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
46-168 2.15e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 49.39  E-value: 2.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWWiytmlFCKVVKFLHK 125
Cdd:cd15070   5 SIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIVVSLGVTIHFY-----SCLFMSCLLV 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRelvmyIWA 168
Cdd:cd15070  80 VFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRR-----IWL 117
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
47-198 2.71e-06

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 49.09  E-value: 2.71e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFD---IILSTsphccwWIYTMLFCKVVKFL 123
Cdd:cd15957   6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGaahILLKT------WTFGNFWCEFWTSI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVAS-VPVFAVTNVAD------IYATSTCTE 194
Cdd:cd15957  80 DVLCVTASIETLCVIAVDRYFAITSPFKYQslLTKNKARVIILMVWIVSGLTSfLPIQMHWYRAThqeainCYAEETCCD 159

                ....
gi 6005772  195 VWSN 198
Cdd:cd15957 160 FFTN 163
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
46-199 2.77e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 48.69  E-value: 2.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFdIILSTSPHccWWIYTMLFCKVVKFLHK 125
Cdd:cd15215   4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPW-VIATSVPL--FWPLDSHLCTALVVLMH 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASV-PVFAVTNVADIYATSTCTEVWSNS 199
Cdd:cd15215  81 LFAFAGVNTIVVVSVDRYLAIIHPLSypTKMTPRRGYLLIYGTWIVSVLQSTpPLYGWGQAAFDERNALCSVIWGSS 157
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
43-329 2.87e-06

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 49.07  E-value: 2.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15971   2 FLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFML-GLPFLAIQVALVH---WPFGKAICRVVMT 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLE----RKISDAKSreLVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSN 198
Cdd:cd15971  78 VDGINQFTSIFCLTVMSIDRYLAVVHPIKsakwRKPRTAKM--INMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  199 S-----LGHLVYVLVYNITTVIVPVVVVFLFLILIRRA----LSASQKKKviiaALRTPQNTISIpyasqreaelhatll 269
Cdd:cd15971 156 EssawyTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSsgirVGSSKRKK----SEKKVTRMVSI--------------- 216
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  270 sMVMVFILCSVPYatlvvyqTVLNVPDTSVFLLLT---------AVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15971 217 -VVAVFVFCWLPF-------YIFNVSSVSVSISPTpglkgmfdfVVVLSYANSCANPILYAFLSDNFKK 277
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
43-176 3.08e-06

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 48.51  E-value: 3.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15061   1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGY---WPLGSHLCDFWIS 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVP 176
Cdd:cd15061  78 LDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMilAVWVISLLITSP 133
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
43-188 3.51e-06

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 49.02  E-value: 3.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTC----RTTVFKSVTNRFIkNLACSGICASLVCVP---FDIILSTSPhccwWIYTML 115
Cdd:cd15135   2 TLTLLYSLILVAGILGNSATIKVTQvlqkKGYLQKSVTDHMV-SLACSDLLVLLLGMPvelYSAIWDPFA----TPSGNI 76
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  116 FCKVVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERK-ISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYA 188
Cdd:cd15135  77 ACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKaLSGSRVRLLICFVWLTSALVALPLLFAMGTEDPLE 150
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
41-282 3.87e-06

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 48.64  E-value: 3.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   41 RQFTTTVQVVIFIGsLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcASLVCVPFdiilstsphccW---------WI 111
Cdd:cd15380   1 RVLPTFIIAICFFG-LLGNLFVLFVFLLPRRRLTIAEIYLANLAASDL-VFVLGLPF-----------WaenirnqfnWP 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  112 YTMLFCKVVKFLHKVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVF---AVTNVADI 186
Cdd:cd15380  68 FGNFLCRVISGVIKANLFISIFLVVAISQDRYRTLVHTMtsRRQRSRRQAQVICLLIWVFGGLLSIPTFlfrSVKHVPDL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  187 yATSTCTEVWSNSLGHLVYVLVYNITTVIVPVVVVFLFlilirralsasqkKKVIIAALRTPQNTISIPYASQREAELHA 266
Cdd:cd15380 148 -NISACILLFPHEAWHFARRVELNIVGFLLPLAAIVFF-------------NFHIIASLRERTEESRKRCGGLKDTKATR 213
                       250
                ....*....|....*.
gi 6005772  267 TLLSMVMVFILCSVPY 282
Cdd:cd15380 214 LILTLVLMFLVCWTPY 229
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
42-176 3.94e-06

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 48.53  E-value: 3.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   42 QFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICaSLVCVPFDIILSTSPHCcwWIYTMLFCKVVK 121
Cdd:cd15967   1 QFLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLL-YLLTLPFLVVYYLKGRK--WIFGQVFCKITR 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  122 FLHKV--FCSVTILSfpAIALDRYYSVLYPLER--KISDAKSRELVMYIWAHAVVASVP 176
Cdd:cd15967  78 FCFNLnlYGSIGFLT--CISVYRYLAIVHPMRVmgRITTTHSVVISALVWLLVVIQSLP 134
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
49-328 4.24e-06

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 48.39  E-value: 4.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIlsTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd15304   8 VIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSML--TILYGYRWPLPSKLCAVWIYLDVLFS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVAS--VPVFAVTNVADIYATSTCTEVWSNSLghLV 204
Cdd:cd15304  86 TASIMHLCAISLDRYIAIRNPIhhSRFNSRTKAFLKIIAVWTISVGISmpIPVFGLQDDSKVFKEGSCLLADENFV--LI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQNTISIPYasqreaelhatLLSMVMVfILCSvPYAT 284
Cdd:cd15304 164 GSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMWCPF-----------FITNVMA-VICK-ESCN 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 6005772  285 LVVYQTVLNVpdtsvfllltAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15304 231 EVVIGGLLNV----------FVWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
50-282 6.48e-06

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 47.78  E-value: 6.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPhcCWWIYTMLFCKVVKFLHKV--F 127
Cdd:cd15161   9 LVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLI-LPMRLVYHLSG--NHWPFGEVPCRLAGFLFYLnmY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  128 CSVTILSFpaIALDRYYSVLYPLE-RKISDAKSRELVMYI-WAHAVVASVPVFAVTNVADIYATSTCTEVW--SNSLGHL 203
Cdd:cd15161  86 ASLYFLAC--ISVDRFLAIVHPVKsMKIRKPLYAHVVCGFlWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYreKASRGAL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVynittvivpvVVVFLFLILIRRALsasqkkkVIIAALRTPQNTisipyasQREAELHA--TLLSMVMVFILCSVP 281
Cdd:cd15161 164 VSLAV----------AFTIPFVTTVTCYL-------LIIRSLRTGKRE-------EKPLKDKAikMIILVLTIFLICFVP 219

                .
gi 6005772  282 Y 282
Cdd:cd15161 220 Y 220
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
51-282 7.66e-06

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 47.53  E-value: 7.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTnRFIKNLACSGICASLVcVPFDIIlsTSPHCCWWIYTMLFCKVVKFLHKVFCSV 130
Cdd:cd15149  10 VFIVGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLT-FPFKIL--SDVELGPWQLNVIVCRYSAVIFYLNMYV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  131 TILSFPAIALDRYYSVLYPLERKI--SDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATST-CTEV-------W---S 197
Cdd:cd15149  86 GIIFFGLIGFDRYYKIVKPLHTSFvqNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEANYTkCARLkselgiqWhkaS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLGHLVYVLVynittvivpvvvvFLFLILIRRALSasqkKKVIIAALRTPQNTISIPYASQReaelhaTLLSMVMVFIL 277
Cdd:cd15149 166 NYICVSIFWVV-------------FLLLIIFYVAIS----RKIYKSNQKFRRNSTNMKAKSSR------NIFSILFVFFV 222

                ....*
gi 6005772  278 CSVPY 282
Cdd:cd15149 223 CFVPY 227
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
50-192 8.01e-06

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 48.02  E-value: 8.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFdiILSTSPHCCWWIYTMLFCKVVKFLHKVFC- 128
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPF--VLVSIRNGSAWTYSVLSCKIVAFMAVLFCf 86
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  129 -------SVTILSFPAIALDRYYSvlypleRKISDAKSRELVMYIWAHAV-VASVPVFAVTNVADIYATSTC 192
Cdd:cd15217  87 haafmlfCISVTRYMAIAHHRFYS------KRMTFWTCIAVICMVWTLSVaMAFPPVFDVGTYKFIREEDQC 152
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-329 1.02e-05

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 47.47  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcvPFDIILSTSPHCCWWIyTMLFCKVVKF 122
Cdd:cd15209   2 ALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIY--PYPLILHAIFHNGWTL-GQLHCQASGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSL 200
Cdd:cd15209  79 IMGLSVIGSIFNITAIAINRYCYICHSLqyDRLYSLRNTCCYLCLTWLLTVLAVLPNFFIGSLQYDPRIYSCTFAQTVST 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 GHLVYVLVYNITTVIVPVVVVFL----FLILIRRALSASQKKKVIIAALRtpqntisipyasqreaelhaTLLSMVMVFI 276
Cdd:cd15209 159 VYTITVVVIHFLLPLLIVSFCYLriwvLVLQVRQRVKPDQRPKLKPADVR--------------------NFLTMFVVFV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  277 LCSVPYATL------VVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15209 219 LFAVCWAPLnfiglaVAINPKEMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
50-329 1.03e-05

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 47.27  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd17790   9 ILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGH---WALGTVACDLWLALDYVASN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVasvpvfavtnvadiyatstcteVWSNSLGHLVYvL 207
Cdd:cd17790  86 ASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMigLAWLISFV----------------------LWAPAILFWQY-L 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  208 VYNITTVIVPVVVVFLFLILIRRALSasqkkkviIAALRTPQNTISIPY-----ASQREAELHATLLSMVMVFILCSVPY 282
Cdd:cd17790 143 VGERTVLAGQCYIQFLSQPIITFGTA--------IAAFYLPVTIMIILYwriyrETIKEKKAARTLSAILLAFILTWTPY 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  283 ATLVVYQTVLN--VPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd17790 215 NIMVLVSTFCKdcVPKT---LWELGYWLCYVNSTVNPMCYALCNKSFRD 260
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
50-181 1.04e-05

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 47.38  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFDIILSTSPHCcwWIYTMLFCKVVK--FLHKVF 127
Cdd:cd15148   9 LIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLL-IICLPFRILYHVNNNQ--WTLGPLLCKVVGnlFYMNMY 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  128 CSVTILSFpaIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAVT 181
Cdd:cd15148  86 ISIILLGF--ISLDRYLKINRSSRRQKFLTRKWSIVAcgVLWAVALVGFVPMIVLT 139
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
46-209 1.42e-05

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 46.73  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGiCASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHK 125
Cdd:cd15121   5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALAD-AAVLLTAPFFLHFLSGGG---WEFGSVVCKLCHYVCG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPLERKISDAKS--RELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHL 203
Cdd:cd15121  81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRsvRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKLCIPYHPSVGHE 160

                ....*.
gi 6005772  204 VYVLVY 209
Cdd:cd15121 161 AFQYLF 166
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
47-179 2.15e-05

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 46.30  E-value: 2.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGiCASLVCVPFDIILSTSPhccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15923   6 IYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVAD-LLLLISLPFKMHSYRRE----SAGLQKLCNFVLSLYYI 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVFA 179
Cdd:cd15923  81 NMYVSIFTITAISVDRYVAIRYPLRARelRSPRKAAVVCAVIWVLVVTISIPYFL 135
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
49-329 2.25e-05

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 46.10  E-value: 2.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLlGNFMVLWSTCRTTVFKSVTNRFIKNLACSGI--CASLVCVPFDIILSTSphccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15210   9 VFMVVGVP-GNLLTVLALLRSKKLRTRTNAFIINLSISDLlfCAFNLPLAASTFLHQA-----WIHGETLCRVFPLLRYG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYP-LERKISDAKSREL-VMYIWAHAVVASVPVFAVTNVADIYATSTCTevwsnslghlv 204
Cdd:cd15210  83 LVAVSLLTLVLITLNRYILIAHPsLYPRIYTRRGLALmIAGTWIFSFGSFLPLWLGIWGRFGLDPKVCS----------- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 yvlvynittvivpvvVVFLfliliRRALSASQKKKVIIAALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYAT 284
Cdd:cd15210 152 ---------------CSIL-----RDKKGRSPKTFLFVFGFVLPCLVIIICYARREDRRLTRMMLVIFLCFLVCYLPITL 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6005772  285 LVVYQTVLNVPdtsVFLLLTAV--WLpkvSLLANPVLFLTVNKSVRK 329
Cdd:cd15210 212 VNVFDDEVAPP---VLHIIAYVliWL---SSCINPIIYVAMNRQYRQ 252
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
43-329 2.48e-05

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 46.00  E-value: 2.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVvifigslLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcvPFDIILSTSPHCCWWIYTMlFCKVVKF 122
Cdd:cd15400   9 FTTVVDI-------LGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALY--PYPLVLVAIFHNGWALGEM-HCKVSGF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSL 200
Cdd:cd15400  79 VMGLSVIGSIFNITGIAINRYCYICHSFayDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCTFVQTASS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 GHLVYVLVYNITTVIVPVVVVFL----FLILIRRALSASQKKKVIIAALRtpqntisipyasqreaelhaTLLSMVMVFI 276
Cdd:cd15400 159 SYTIAVVVIHFIVPITVVSFCYLriwvLVIQVRRKVKSESKPRLKPSDFR--------------------NFLTMFVVFV 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  277 LCSVPYATLVVYQTVLNV------PDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15400 219 IFAICWAPLNLIGLAVAInpqemaPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRK 277
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
50-176 2.85e-05

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 45.95  E-value: 2.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15054   9 LIILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLVVMPPAMLNALYGR---WVLARDFCPIWYAFDVMCCS 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYI--WAHAVVASVP 176
Cdd:cd15054  86 ASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILaaWTLAALASFL 134
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
51-308 2.97e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 45.70  E-value: 2.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGS-----LLGNFMVLWSTcrtTVFKSV---TNRFIKNLACSGICASLVCVPFDIILSTSPhcCWWiYTMLFCKVVKF 122
Cdd:cd15314   5 IFLGLislvtVCGNLLVIISI---AHFKQLhtpTNYLILSLAVADLLVGGLVMPPSMVRSVET--CWY-FGDLFCKIHSS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPL--ERKISdaKSRELVMYI--WA-HAVVASVPVFAVTNVADIY-ATSTCTEvw 196
Cdd:cd15314  79 FDITLCTASILNLCFISIDRYYAVCQPLlyRSKIT--VRVVLVMILisWSvSALVGFGIIFLELNIKGIYyNHVACEG-- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 snslghlvYVLVYNITTVIVPVVVVFLFL-------ILIRRALSASQKKKVIIAALRTPQNTISipyASQREAelhATLL 269
Cdd:cd15314 155 --------GCLVFFSKVSSVVGSVFSFYIpavimlcIYLKIFLVAQRQARSIQSARTKSGASSS---KMERKA---TKTL 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 6005772  270 SMVM-VFILCSVPYATLVVYQTVLNVPdTSVFLLLTAVWL 308
Cdd:cd15314 221 AIVMgVFLLCWTPFFLCNIIDPFINYS-IPPVLIEVLNWL 259
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
49-198 3.27e-05

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 46.16  E-value: 3.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772    49 VVIFIGSLLGNFMVLwstcrTTVF----KSVTNRFIKNLACSGICAsLVCVPFdIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:PHA02638 106 IIIFILGLFGNAAII-----MILFckkiKTITDIYIFNLAISDLIF-VIDFPF-IIYNEFDQ---WIFGDFMCKVISASY 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   125 KVFCSVTILSFPAIALDRYYSVLYPlerkISDAKSRE------LVMYIWAHAVVASVP---VFAVTNVadIYATSTCTEV 195
Cdd:PHA02638 176 YIGFFSNMFLITLMSIDRYFAILYP----ISFQKYRTfnigiiLCIISWILSLIITSPayfIFEASNI--IFSAQDSNET 249

                 ...
gi 6005772   196 WSN 198
Cdd:PHA02638 250 ISN 252
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
46-198 3.50e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 45.58  E-value: 3.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLAcsgiCASLVCVPFDIIlstsPHCCWWIyTMLF------CKV 119
Cdd:cd15385   5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLS----LADLVVAFFQVL----PQLCWDI-TYRFygpdflCRI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  120 VKFLH--KVFCSVTILSfpAIALDRYYSVLYPLeRKISDAKSRELVMYI--WAHAVVASVPVFAVTNVADIYATSTCTEV 195
Cdd:cd15385  76 VKHLQvlGMFASTYMLV--MMTADRYIAICHPL-KTLQQPTKRSYLMIGsaWALSFILSTPQYFIFSLSEIENGSGVYDC 152

                ...
gi 6005772  196 WSN 198
Cdd:cd15385 153 WAN 155
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
52-192 3.55e-05

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 45.52  E-value: 3.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   52 FIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPF--DIILSTSPhccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd14991  11 FVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLL-LICLPFriDYYLRGEH----WIFGEAWCRVNLFMLSVNRS 85
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  130 VTILSFPAIALDRYYSVLYPLER--KISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTC 192
Cdd:cd14991  86 ASIAFLTAVALDRYFKVVHPHHRvnRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSC 150
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
51-176 3.86e-05

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 45.53  E-value: 3.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIilstspHCCWWIYTMLF----CKVVKFLHKV 126
Cdd:cd15358  10 IFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLGMPLEL------YEMWSNYPFLLgaggCYFKTLLFET 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVP 176
Cdd:cd15358  84 VCFASILNVTALSVERYIAVVHPLKAKyvVTRTHAKRVIGAVWVVSILCSIP 135
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
47-320 4.64e-05

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 45.18  E-value: 4.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFdiiLSTSPHCCWWIYTMLFCKVVKFLHKV 126
Cdd:cd15972   6 VYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFML-GLPF---LAAQNALSYWPFGSFMCRLVMTVDAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLE----RKISDAKSRELVmyIWAHAVVASVPVFAVTNVADiyATSTCTEVWSN---- 198
Cdd:cd15972  82 NQFTSIFCLTVMSVDRYLAVVHPIRsskwRKPPVAKTVNAT--VWALSFLVVLPVVIFSGVPG--GMGTCHIAWPEpaqv 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  199 -SLGHLVYVLVYNITTVIVPVVVVFLFLILIRRalsaSQKKKVIIAALRTPQNtisipyasqrEAELHATLLSMVMVFIL 277
Cdd:cd15972 158 wRAGFIIYTATLGFFCPLLVICLCYLLIVVKVR----SSGRRVRATSTKRRGS----------ERKVTRMVVIVVAAFVL 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 6005772  278 CSVPYATLVVYQTVLNVPDTSVF--LLLTAVWLPKVSLLANPVLF 320
Cdd:cd15972 224 CWLPFYALNIVNLVCPLPEEPSLfgLYFFVVVLSYANSCANPIIY 268
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
51-325 4.68e-05

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 44.97  E-value: 4.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCSV 130
Cdd:cd15330  10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNK---WTLGQVTCDLFIALDVLCCTS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  131 TILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASV-PVFAVTNVADIYATSTCTevWSNSLGHLVYvl 207
Cdd:cd15330  87 SILHLCAIALDRYWAITDPIDyvNKRTPRRAAVLISLTWLIGFSISIpPMLGWRTPEDRSDPDACT--ISKDPGYTIY-- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  208 vyniTTVIVPVVVVFLFLILIRRalsasqkkkviiaalrtpqntisIPYASQREAELHATLLSMVMVFILCSVPYatlVV 287
Cdd:cd15330 163 ----STFGAFYIPLILMLVLYGR-----------------------IFKAAARERKTVKTLGIIMGTFILCWLPF---FI 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 6005772  288 YQTVLNVPDTSVFL--LLTAV--WLPKVSLLANPVLFLTVNK 325
Cdd:cd15330 213 VALVLPFCESTCHMpeLLGAIinWLGYSNSLLNPIIYAYFNK 254
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
44-331 5.83e-05

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 45.23  E-value: 5.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDI--ILSTSphccwWIYTMLFCKVVK 121
Cdd:cd15976   3 NTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIDIPINVykLLAED-----WPFGVEMCKLVP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FLHKVFCSVTILSFPAIALDRYYSVLYPLERK---ISDAKSRELVMyIWAHAVVASVP-VFAVtnvaDIYATSTCTEVWS 197
Cdd:cd15976  78 FIQKASVGITVLSLCALSIDRYRAVASWSRIKgigVPKWTAVEIVL-IWVVSIILAVPeAIGF----DMITMDYKGELLR 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQN-TISIPYASQREAELHATLLSMVMVFI 276
Cdd:cd15976 153 ICLLHPIQKTAFMQFYKTAKDWWLFSFYFCLPLACTAVFYTLMTCEMLRKKNGmQIALNDHLKQRREVAKTVFCLVLVFA 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  277 LCSVP-YATLVVYQTVLNVPDT------SVFLLLTAVWLPKVSLLA--NPVLFLTVNKSVRKCL 331
Cdd:cd15976 233 LCWLPlHLSRILKLTIYDEKDPnrcellSFFLVLDYIGINMASLNSciNPIALYLVSKRFKNCF 296
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
50-329 5.93e-05

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 44.76  E-value: 5.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcaslvcvpfdIILSTSPH-----CCWWIYTMLFCKVVKFLH 124
Cdd:cd15173   9 VMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADL----------LFLCTLPFwaysaAHEWIFGTVMCKITNGLY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPleRKISDAKSRELV------MYIWAHAVVASVPVFAVTNVADiYATSTCTEVW-S 197
Cdd:cd15173  79 TINLYSSMLILTCITVDRFIVIVQA--TKAHNCHAKKMRwgkvvcTLVWVISLLLSLPQFIYSEVRN-LSSKICSMVYpP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSAS--QKKKVIiaalrtpqntisipyasqreaelhATLLSMVMVF 275
Cdd:cd15173 156 DAIEVVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKgfQKHKSL------------------------KIIFVVVAVF 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  276 ILCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLL---ANPVLFLTVNKSVRK 329
Cdd:cd15173 212 ILTQLPYNIMKLIRTLHIENTDSTNFKYAILITEAIAYLhacLNPILYAFVGVKFRK 268
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
47-329 6.22e-05

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 44.90  E-value: 6.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcvPFDIILSTSPHCCWwIYTMLFCKVVKFLHKV 126
Cdd:cd15401   6 VLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVY--PYPLILLAIFHNGW-TLGNIHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLV 204
Cdd:cd15401  83 SVIGSVFNITAIAINRYCYICHSLryDKLYNMKKTCCYVCLTWVLTLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSYTI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  205 YVLVYNITTVIVPVVVVFL----FLILIRRALSASQKKKVIIAALRtpqntisipyasqreaelhaTLLSMVMVFILCSV 280
Cdd:cd15401 163 TVVVVHFIVPLSIVTFCYLriwvLVIQVKHRVRQDSKQKLKANDIR--------------------NFLTMFVVFVLFAV 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  281 PYATL------VVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15401 223 CWGPLnfiglaVAINPLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRK 277
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
49-292 6.41e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 44.96  E-value: 6.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPhccwWIYTMLFCKVVKFLHKV-- 126
Cdd:cd15178   8 VLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALT-LPFWAVSVVKG----WIFGTFMCKLVSLLQEAnf 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSfpAIALDRYYSVLYPLErkiSDAKSRELVMY----IWAHAVVASVPVFAVTNVA--DIYATSTCTEVWSNS- 199
Cdd:cd15178  83 YSGILLLA--CISVDRYLAIVHATR---ALTQKRHLVKFvcagVWLLSLLLSLPALLNRDAFkpPNSGRTVCYENLGNEs 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 --------------LGHLVYVLVynittvivpvvVVFLFLILIRRALSA--SQKKK---VIIAalrtpqntisipyasqr 260
Cdd:cd15178 158 adkwrvvlrilrhtLGFLLPLVV-----------MLFCYGFTIKTLLQTrsFQKHRamrVIFA----------------- 209
                       250       260       270
                ....*....|....*....|....*....|..
gi 6005772  261 eaelhatllsMVMVFILCSVPYATLVVYQTVL 292
Cdd:cd15178 210 ----------VVLAFLLCWLPYNVTVLIDTLM 231
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
47-150 7.25e-05

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 44.76  E-value: 7.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICasLVCV-PFDIILSTSPHCcwWIYTMLFCKVVK--FL 123
Cdd:cd15368   6 VYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLM--LACFlPFQIVYHIQRNH--WIFGKPLCNVVTvlFY 81
                        90       100
                ....*....|....*....|....*..
gi 6005772  124 HKVFCSvtILSFPAIALDRYYSVLYPL 150
Cdd:cd15368  82 ANMYSS--ILTMTCISIERYLGVVYPM 106
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
44-177 7.46e-05

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 44.95  E-value: 7.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIGSLLGNFMVLWSTCRTTVFKS-VTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMlFCKV-VK 121
Cdd:cd15319   3 TGCLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGY---WPFGA-FCDVwVA 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FlhKVFCSV-TILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVAS-VPV 177
Cdd:cd15319  79 F--DIMCSTaSILNLCVISVDRYWAISSPFryERKMTQRVALVMISVAWTLSVLISfIPV 136
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
50-331 7.97e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 44.42  E-value: 7.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLgNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVpFDIILSTSPHccWWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15076  10 VFIVGTPL-NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSV-FPVFVASAQG--YFFFGRTVCALEAFVGSLAGL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLER-KISDAKSRELVMYIWAHAVVASVPVF-----------AVTNVADIYATSTctevWS 197
Cdd:cd15076  86 VTGWSLAFLAFERYIVICKPFGNfRFGSKHALGAVVATWIIGIGVSLPPFfgwsryipeglQCSCGPDWYTVGT----KY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKviiaalrtpqntisipyASQREAELHATLLSMVMV--F 275
Cdd:cd15076 162 RSEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQES-----------------ASTQKAEREVSRMVVVMVgsF 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  276 ILCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15076 225 CLCYVPYAALAMYMVNNRDHGLDLRLVTIPAFFSKSSCVYNPIIYCFMNKQFRACI 280
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
56-331 8.50e-05

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 44.48  E-value: 8.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   56 LLGNFMVLW--STCRTTVFkSVTNRFIKNLACSGICASLVcVPF---DIILSTSphccwWIYTMLFCKVVKFLHKVFCSV 130
Cdd:cd15925  15 LLGNLAVMYllRNCARRAP-PPIDVFVFNLALADFGFALT-LPFwavESALDFH-----WPFGGAMCKMVLTATVLNVYA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  131 TILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTC-----TEVWSNSLgHL 203
Cdd:cd15925  88 SVFLLTAMSVTRYWVVASAAGpgTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCllkfpSNYWLGAY-HL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKkviiaalrtpqntisipyasQREAELHATLLSMVMVFILCSVP-- 281
Cdd:cd15925 167 QRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNR--------------------QRQSVIARSVRLVVASFFLCWFPnh 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  282 ----YATLVVYQTvlnVPDTSVFLLLTAVWLPKVSLLA------NPVLFLTVNKSVRKCL 331
Cdd:cd15925 227 vvtfWGVLVKFRA---VPWNSTFYFIHTYVFPVTTCLAhsnsclNPVLYCLMRREFRQAL 283
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
49-335 8.70e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 44.47  E-value: 8.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLgNFMVLWSTCRTTVFKSVTNRFIKNLACsgicASLVCVPFDIILSTSPHCC-WWIYTMLFCKVVKFLHKVF 127
Cdd:cd15084  19 MVVALASFV-NGLVIVVSIKYKKLRSPLNYILVNLAV----ADLLVTLFGSSVSFSNNIVgFFVFGKTMCEFEGFMVSLT 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  128 CSVTILSFPAIALDRYYSVLYPLERkiSDAKSRELVM---YIWAHAVVASVP-VFAVTNVADIYATSTCTEVW----SNS 199
Cdd:cd15084  94 GIVGLWSLAILAFERYLVICKPMGD--FRFQQRHAVSgcaFTWGWSLLWTSPpLFGWSSYVPEGLRTSCGPNWytggTNN 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKviiaalRTPQntisipyasQREAELHATLLSMVMVFILCS 279
Cdd:cd15084 172 NSYILALFVTCFALPLSTIIFSYSNLLLTLRAVAAQQKES------ETTQ---------RAEKEVTRMVIAMVMAFLICW 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  280 VPYATL-VVYQTVLNVPDTSVFLLLTAvWLPKVSLLANPVLFLTVNKSVRKCLIGTL 335
Cdd:cd15084 237 LPYATFaMVVATNKDVVIQPTLASLPS-YFSKTATVYNPIIYVFMNKQFRSCLLELL 292
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
49-328 1.02e-04

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 44.36  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICaslVCVPFDIILSTSPHCCWWIYTMLFCKVVKFLHKVFC 128
Cdd:cd14987   8 IFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLC---VVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSINL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSFPAIALDRYYSVLYPLERKISDAK--SRELVMYIWAHAVVASVPvfavtnvaDIYATSTCTEVWSN-SLGHLVY 205
Cdd:cd14987  85 FGSIFFLTCMSVDRYLSVTLFGNTSSRRKKivRRIICVLVWLLAFVASLP--------DTYFLKTVTSPSNNeTYCRSFY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  206 V------------LVYNITTVIVPVVVVFLFLILIRRALSASQKKKviiaaLRTPQNTIsipyasqreaelhatlLSMVM 273
Cdd:cd14987 157 PeesfkewligmeLVSIVLGFVIPFPIIAVFYFLLARAISASSDQE-----RKSSRKII----------------FSYVV 215
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  274 VFILCSVPYATLVVYQ--TVLNVPDTSVFL---LLTAVWLPK-VSLL---ANPVLFLTVNKSVR 328
Cdd:cd14987 216 VFLVCWLPYHTVVLLDilSFLHLIPFSCQLenfLYAALHVTQcFSLVhccVNPILYSFINRNYR 279
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
43-175 1.20e-04

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 43.79  E-value: 1.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccWWIYTMLFCKVVKF 122
Cdd:cd15328   2 LVLTLLAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGR--RWQLGRSLCQVWIS 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAK--SRELVMYIWAHAVVASV 175
Cdd:cd15328  80 FDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRriSNVMIALTWALSAVISL 134
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
47-210 1.38e-04

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 43.76  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACsgicASLVCVPFDIIlstsPHCCWWIyTMLF------CKVV 120
Cdd:cd15196   6 VLATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSV----ADLLVALFNVL----PQLIWDI-TYRFyggdllCRLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  121 KFLHKV--FCSVTILSfpAIALDRYYSVLYPLER-KISDAKSRELVMYIWAHAVVASVP-VFAVTNVADIYATSTCTEVW 196
Cdd:cd15196  77 KYLQVVgmYASSYVLV--ATAIDRYIAICHPLSShRWTSRRVHLMVAIAWVLSLLLSIPqLFIFSYQEVGSGVYDCWATF 154
                       170
                ....*....|....
gi 6005772  197 SNSLGHLVYVLVYN 210
Cdd:cd15196 155 EPPWGLRAYITWFT 168
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
49-171 1.47e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 43.60  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLLGNFMVLWSTCRTT-VFKSVTNRFIKNLACSGICASLVCVPFD---IILSTSPhccwwiYTMLFCKVVKFLH 124
Cdd:cd15219   7 VVVLVVSLLSNLLVLLCFLYSAeLRKQVPGIFLLNLSFCNLLLTVLNMPFTllgVVRNRQP------FGDGFCQAVGFLE 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLeRKISDAKSRE---LVMYIWAHAV 171
Cdd:cd15219  81 TFLTSNAMLSMAALSIDRWIAVVFPL-SYTSKMRYRDaalMVGYSWLHSL 129
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
55-193 1.59e-04

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 43.87  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   55 SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFdiILSTSPHCCWWIYTMLFCKVVKFLHKVFCSVTILS 134
Cdd:cd15218  14 SVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPF--VFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHTAFM 91
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  135 FPAIALDRYYSVLYP--LERKISDAKSRELVMYIWAHAV-VASVPVFAVTNVADIYATSTCT 193
Cdd:cd15218  92 LFCISVTRYLAIAHHrfYTKRLTFWTCLAVICMVWTLSVaMAFPPVLDVGTYSFIREEDQCT 153
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
56-177 1.60e-04

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 43.63  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   56 LLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASlVCVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKVFCSVTILSF 135
Cdd:cd15199  15 LPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLL-ICLPFKAYFYLNGNR--WSLGGGTCKALLFMLSLSRGVSIAFL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 6005772  136 PAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPV 177
Cdd:cd15199  92 TAVALDRYFRVVHPRGKKnsLSLQAAPYISFLVWLLLVGLTIPT 135
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
50-178 1.63e-04

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 43.59  E-value: 1.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLAcsgiCASLVCvpfdiiLSTSPhcCW---------WIYTMLFCKVV 120
Cdd:cd15191   9 IIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLA----VADLLF------LATLP--LWatyysygynWLFGSVMCKIC 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  121 KFLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAK-SRELVMYIWAHAVVASVPVF 178
Cdd:cd15191  77 GSLLTLNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWqARLVCLLVWVLACLSSLPTF 135
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
50-199 1.65e-04

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 43.63  E-value: 1.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFDIILSTSPhccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15187   9 LLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLF-VFSLPFQAYYLLDQ----WVFGNAMCKIVSGAYYIGFY 83
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  130 VTILSFPAIALDRYYSVLYPL-ERKISDAK-SRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNS 199
Cdd:cd15187  84 SSMFFITLMSIDRYLAIVHAVyALKVRTAShGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQ 155
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
46-329 1.71e-04

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 43.48  E-value: 1.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIgSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDI---ILStsphccWWIYTMLFCKVVKF 122
Cdd:cd15059   6 IVSVVILL-IIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLvneLMG------YWYFGSVWCEIWLA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYI--WAHAVVASVP-VFAVTNVADIYATSTCTEVwSNS 199
Cdd:cd15059  79 LDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAavWIISAVISLPpLFGWKDEQPWHGAEPQCEL-SDD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGhlvYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIaalrtpqntisipyasqreaelhatlLSMVM-VFILC 278
Cdd:cd15059 158 PG---YVLFSSIGSFYIPLLIMIIVYARIYRAAKRKERRFTLV--------------------------LGVVMgAFVLC 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  279 SVPYATLVVYQTV---LNVPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15059 209 WLPFFFTYPLVVVcktCGVPEL---LFKFFFWLGYCNSALNPVIYTIFNKDFRR 259
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-193 1.75e-04

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 43.60  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWstcrtTVFKSVTNR------FIKNLACSGIcASLVCVPFdiilstsphccWWIYTML---- 115
Cdd:cd15190  15 VIYMLVFVLGLSGNGLVLW-----TVFRSKRKRrrsadtFIANLALADL-TFVVTLPL-----------WAVYTALgyhw 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  116 -----FCKVVKFL------HKVFCsVTILSFpaialDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTN 182
Cdd:cd15190  78 pfgsfLCKLSSYLvfvnmyASVFC-LTGLSF-----DRYLAIVRSLAsaKLRSRTSGIVALGVIWLLAALLALPALILRT 151
                       170
                ....*....|.
gi 6005772  183 VADIYATSTCT 193
Cdd:cd15190 152 TSDLEGTNKVI 162
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
258-331 1.81e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 43.61  E-value: 1.81e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005772  258 SQREAELHATLLSMVMVFILCSVPYATLVVyqTVLNVPDTSVFLLLTAV--WLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15075 206 AKAEVQVARMVVVMVMAFLLCWLPYAAFAL--TVVSKPDVYINPLIATVpmYLAKSSTVYNPIIYIFMNKQFRDCA 279
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
50-328 2.08e-04

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 43.21  E-value: 2.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGI--CASLVCVPFDIILSTSphccwWIYTMLFCKVVKFL--HK 125
Cdd:cd16001   9 VVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLlyVCSLPLLIVNYAMRDR-----WPFGDFLCKLVRFLfyTN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  126 VFCSVTILSfpAIALDRYYSVLYPLerKISDAKSRELVMY----IWAHAVVASVPVFAVTNVADIYATSTCTEVWS--NS 199
Cdd:cd16001  84 LYGSILFLT--CISVHRFLGVCYPI--RSLAYRTRRLAVIgsaaTWILVVLQLLPTLVYARTGSINNRTVCYDLTSpdNF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  200 LGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTpqntisipyASQReaelhaTLLSMVMVFILCS 279
Cdd:cd16001 160 GNYFPYGMVLTVTGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAARA---------KSIR------TILLVCGLFALCF 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  280 VPY---ATLVVYQTVLNVPDTSVFLLLTA---VWLPKVSLLA--NPVLFLTVNKSVR 328
Cdd:cd16001 225 VPFhitRTIYLFVRVYLVQDCPLLQFVSLaykIWRPLVSFNSciNPLLYFLSGDSNR 281
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
43-298 2.27e-04

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 43.22  E-value: 2.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFDIILSTSPhccwWIYTMLFCKVVKF 122
Cdd:cd15175   2 FLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILF-LLTLPFWAASAAKK----WVFGEEMCKAVYC 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVLypleRKISDAKSRELVMY--------IWAHAVVASVPVFAVTNVADIYATSTCTE 194
Cdd:cd15175  77 LYKMSFFSGMLLLMCISIDRYFAIV----QAASAHRHRSRAVFiskvsslgVWVLAFILSIPELLYSGVNNNDGNGTCSI 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  195 VWSNSLGHLVYVLVYNITT--VIVPVVVVFLFLILIRRALSAS--QKKKVIiaalrtpqntisipyasqreaelhATLLS 270
Cdd:cd15175 153 FTNNKQTLSVKIQISQMVLgfLVPLVVMSFCYSVIIKTLLQARnfEKNKAI------------------------KVIIA 208
                       250       260
                ....*....|....*....|....*...
gi 6005772  271 MVMVFILCSVPYATLVVYQTVLNVPDTS 298
Cdd:cd15175 209 VVVVFVVFQLPYNSVMLVSTLSSFKGNT 236
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
46-329 2.27e-04

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 43.09  E-value: 2.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACsgicASLVCVPFDIILSTSPHCC-WWIYTMLFCKVVKFLH 124
Cdd:cd15300   5 AVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLAC----ADLIIGIFSMNLYTSYILMgYWALGSLACDLWLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAvtnvadiyatstcteVWSnslgh 202
Cdd:cd15300  81 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMigLAWLISFILWAPPIL---------------CWQ----- 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  203 lvyVLVYNITTVIVPVVVVFLFLILIRRALSasqkkkviIAALRTPQNTISIPYA-----SQREAELHATLLSMVMVFIL 277
Cdd:cd15300 141 ---YFVGKRTVPERECQIQFLSEPTITFGTA--------IAAFYIPVSVMTILYCriykeTIKERKAAQTLSAILLAFII 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6005772  278 CSVPYATLVVYQTVLN--VPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15300 210 TWTPYNIMVLVSTFCSdcIPLT---LWHLGYWLCYVNSTVNPMCYALCNKTFRK 260
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
47-179 2.47e-04

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 43.12  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTC-RTTVFKSVTnRFIKNLACSGICAsLVCVPF--DIILSTSPhccwWIYTMLFCKVVKFL 123
Cdd:cd15201   6 VLILEFVLGLLGNGLALWIFCfHLKSWKSST-VYLFNLAVADFLL-IICLPFrtDYYLRGKH----WKFGDIPCRIVLFM 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLER--KISDAKSRELVMYIWAHAVVASVPVFA 179
Cdd:cd15201  80 LAMNRAGSIFFLTAVAVDRYFRVVHPHHRinSISVRKAAIIACGLWLLTIAMTVYLLT 137
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
53-331 2.74e-04

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 42.69  E-value: 2.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   53 IGSLL---GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15049   9 SLSLVtvgGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGY---WPLGPLLCDLWLALDYVASN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYI---------WAHAVVASVPVFAVTNVADiyatSTCtevwsnsl 200
Cdd:cd15049  86 ASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIAlawvisfvlWAPAILGWQYFVGERTVPD----GQC-------- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  201 ghlvYVlvynittvivpvvvVFLFLILIRRALsasqkkkvIIAALRTPQNTISIPY-----ASQREAELHATLLSMVMVF 275
Cdd:cd15049 154 ----YI--------------QFLDDPAITFGT--------AIAAFYLPVLVMTILYwriyrETARERKAARTLSAILLAF 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  276 ILCSVPYATLVVYQTVLN--VPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15049 208 IITWTPYNILVLVSTFCAkcIPDT---LWSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-177 2.90e-04

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 42.63  E-value: 2.90e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRF---IKNLACSGICASLVCVP---FDIILSTSPhccwWIYTMLFCK 118
Cdd:cd15130   4 TAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLAMPvelYNFIWVHHP----WAFGDAGCR 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6005772  119 VVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPV 177
Cdd:cd15130  80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKtlMSRSRTKKFISAIWLASALLAIPM 140
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
43-320 3.23e-04

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 42.83  E-value: 3.23e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPHCcwWIYTMLFCKVVK- 121
Cdd:cd15369   2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLL-LPFKIAYHFSGND--WLFGEAMCRVVTa 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 -FLHKVFCSVTILSfpAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAVTNVADI--YATSTCTEVW 196
Cdd:cd15369  79 aFYCNMYCSILLMT--CISVDRFLAVVYPMQSLSWRTLRRASFTcaAIWLLSIAGVVPLLLSEQTIQIpdLGITTCHDVL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGHLVYVLVYnittviVPVVVVFLFLILIRRALSASQkkkvIIAALrtpqNTISIPYASQREAELHATLLSMVMVFI 276
Cdd:cd15369 157 NEQLLMGYYVYYF------SIFSCLFFFVPLIITTVCYVS----IIRCL----SSSSDVANSSKKTRALFMAVAVFCVFV 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 6005772  277 LCSVPYATLVVYQTV----LNVPDTSVFLLLTAVWLPKVSLLANPVLF 320
Cdd:cd15369 223 ICFGPTNVLLLAHYVrfayTSTNDASYFAYLLCVCVGSISCCLDPLIY 270
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
50-330 3.43e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 42.47  E-value: 3.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15333  13 LITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVSILVMPISIVYTVTGT---WTLGQVVCDIWLSSDITCCT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAVTNVADIYATSTCTeVWSNSLGHLVYVL 207
Cdd:cd15333  90 ASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMiaLVWVISISISLPPFFWRQAKAEEEVSECV-VNTDHILYTVYST 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  208 VynittvIVPVVVVFLFLILIRRALSAsqkkkviiaalrtpqntisipyASQREAELHATLLSMVMVFILCSVPYatlVV 287
Cdd:cd15333 169 V------GAFYIPTLLLIALYGRIYVE----------------------ARARERKATKTLGIILGAFIVCWLPF---FI 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6005772  288 YQTVLNV-PDTSVFLLLTAV---WLPKVSLLANPVLFLTVNKSVRKC 330
Cdd:cd15333 218 ISLVLPIcKDACWFHLAIFDfftWLGYLNSLINPIIYTMSNEDFKQA 264
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
43-291 3.46e-04

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 42.43  E-value: 3.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPFDIILSTSPhccwWIYTMLFCKVVKF 122
Cdd:cd15172   2 FVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILF-VLTLPFWAVYEAHQ----WIFGNFSCKLLRG 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKV--FCSVTILSFpaIALDRYYSVLYPLE----RKISDAKSRELVMYIWAHAVVASVPVFAVTNVAD--IYATSTCTE 194
Cdd:cd15172  77 IYAInfYSGMLLLAC--ISVDRYIAIVQATKsfrlRSRTLAYSKLICAAVWLLAILISLPTFIFSEVYDfgLEEQYVCEP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  195 VWSNSLGHLVYVLVYNITTVIVPVVVVFLFLILIRralsasqkkKVIIAALRTPQNtisipyaSQREAELHaTLLSMVMV 274
Cdd:cd15172 155 KYPKNSTAIMWKLLVLSLQVSLGFFIPLLVMIFCY---------SFIIKTLLQAQN-------SQRHKAVR-VVVAVVLV 217
                       250
                ....*....|....*..
gi 6005772  275 FILCSVPYATLVVYQTV 291
Cdd:cd15172 218 FLVCQVPYNIVLLIEAI 234
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
49-150 3.65e-04

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 42.54  E-value: 3.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGSLL---GNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTspHCCWWiYTMLFCKVVKFLHK 125
Cdd:cd15316   5 IVLGFGAVLavfGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSV--ESCWY-FGESFCTFHTCCDV 81
                        90       100
                ....*....|....*....|....*
gi 6005772  126 VFCSVTILSFPAIALDRYYSVLYPL 150
Cdd:cd15316  82 SFCYASLFHLCFISVDRYIAVTDPL 106
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
44-320 3.72e-04

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 42.37  E-value: 3.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHCCWwIYTMLFCKVVKFL 123
Cdd:cd14995   3 ATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGPDSW-IYGYAGCLLITYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSR--ELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLG 201
Cdd:cd14995  82 QYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRakKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIVVRCGYKVS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 HLVYVLVYNITTVIVPVVVVFLFLIL---IRRALSASQKKKVIIAALrtpqntisipyasqreaelhatllsMVMVFILC 278
Cdd:cd14995 162 RHYYLPIYLADFVLFYVIPLLLAIVLyglIGRILFSSRKQVTKMLAV-------------------------VVVLFALL 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 6005772  279 SVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLF 320
Cdd:cd14995 217 WMPYRTLVVYNSFASPPYLDLWFLLFCRTCIYLNSAINPILY 258
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
50-152 4.50e-04

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 42.09  E-value: 4.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvCVPFDIILSTsphccwWIYTMLFCKVVK--FLHKVF 127
Cdd:cd15920   9 IICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVL-CLPFRVAYQN------TAGPLSFCKIVGafFYLNMY 81
                        90       100
                ....*....|....*....|....*
gi 6005772  128 CSVTILSFpaIALDRYYSVLYPLER 152
Cdd:cd15920  82 ASILFLSL--ISLDRYLKIIKPLQQ 104
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
42-285 5.75e-04

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 41.72  E-value: 5.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   42 QFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICasLVC-VPFDIILSTspHCCWWIYTMLFCKVV 120
Cdd:cd15921   1 LFYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLL--LVCtLPLRLTYYV--LNSHWPFGDIACRII 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  121 KFLHKV--FCSVTILSfpAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVW 196
Cdd:cd15921  77 LYVLYVnmYSSIYFLT--ALSVFRYLALVWPYLylRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLELA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  197 SNSLGhlvYVLVYNITTVIVPVVVVFLFLILIrralsasqkKKVIIAALRTPQNTISIPYASQREAelHATLLSMVMVFI 276
Cdd:cd15921 155 HDAVD---KLLLINYVTLPVGFVVPFMTVIFC---------YIFIIKNLLKPSPALGRTRPSRRKA--CALIIISLGIFL 220

                ....*....
gi 6005772  277 LCSVPYATL 285
Cdd:cd15921 221 VCFLPYHIV 229
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-176 6.08e-04

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 41.74  E-value: 6.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDI--ILSTSPHCCWWIYTMLFCKVVKF 122
Cdd:cd15128   4 TVVSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIDLPINVykLLAMDWPFGDQPFGQFLCKLVPF 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYSVL---------YPLERKIsdaksrELVMyIWAHAVVASVP 176
Cdd:cd15128  84 IQKASVGITVLNLCALSVDRYRAVAswsriqgigIPMWTAV------EIVM-IWMLSAVLAVP 139
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
46-178 6.43e-04

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 41.82  E-value: 6.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWS-TCRTTVFKSVTnRFIKNLACSGICASLVcVPFDIILSTSPhcCWWIYTMLFCKVVKFLH 124
Cdd:cd15377   5 AVYILVFITGFLGNSVAIWMfVFHMKPWSGIS-VYMFNLALADFLYVLT-LPALIFYYFNK--TDWIFGDAMCKLQRFIF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  125 KVFCSVTILSFPAIALDRYYSVLYPLeRKISDAKSRELVM---YIWAHAVVASVPVF 178
Cdd:cd15377  81 HVNLYGSILFLTCISVHRYTGVVHPL-KSLGRLKKKNAICisvLVWLIVVVAISPIL 136
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
50-178 6.67e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 41.95  E-value: 6.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPhccWWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15065   8 LIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLG---YWLFGETFCNIWISFDVMCST 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVMY--IW-AHAVVASVPVF 178
Cdd:cd15065  85 ASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIasVWiLSALISFLPIH 136
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
47-176 7.21e-04

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 41.47  E-value: 7.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLG---NFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFL 123
Cdd:cd15334   3 ISLTLSILALMTtaiNSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKET---WIMGQVVCDIWLSV 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLE--RKISDAKSRELVMYIWAHAVVASVP 176
Cdd:cd15334  80 DITCCTCSILHLSAIALDRYRAITDAVEyaRKRTPKHAGIMIAVVWIISIFISMP 134
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
50-304 7.71e-04

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 41.27  E-value: 7.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICAsLVCVPF---DIILStsphccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15176   9 IALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLL-LFTLPFwaaDAVNG-------WVLGTAMCKITSALYTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVYV 206
Cdd:cd15176  81 NFSCGMQFLACISVDRYVAITKATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLVTSAKA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  207 LVynittVIVPVVVVFL--FLILIrralsaSQKKKVIIAALRTPQNTISIPYasqreaelhATLLSMVMVFILCSVPYAT 284
Cdd:cd15176 161 TI-----QILEVLLGFVlpFLVMV------FCYSRVARALSRTPNVKKSRAL---------KVLLAVVGVFIVTQLPYNV 220
                       250       260
                ....*....|....*....|
gi 6005772  285 LVVYQTVlnvpdTSVFLLLT 304
Cdd:cd15176 221 VKFYRAI-----DVIYLLIT 235
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
257-331 8.27e-04

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 41.36  E-value: 8.27e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  257 ASQREAELHATLLSMVMV--FILCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15080 204 ATTQKAEKEVTRMVIIMViaFLICWVPYASVAFYIFTHQGSDFGPIFMTIPAFFAKSSAVYNPVIYILMNKQFRNCM 280
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-331 9.07e-04

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 41.27  E-value: 9.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcASLVCVPFdiILST--SPHccwWIYTMLFCKVVKFL 123
Cdd:cd14999   4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADL-LYLLTIPF--YVSTyfLKK---WYFGDVGCRLLFSL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  124 HKVFCSVTILSFPAIALDRYYSVLYPLE-RKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATST-----CTEVWS 197
Cdd:cd14999  78 DFLTMHASIFTLTVMSTERYLAVVKPLDtVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKSGgskriCLPTWS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 nSLGHLVYVLVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIAALRTPQntisipyasQREAELhatLLSMVMVFIL 277
Cdd:cd14999 158 -EESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPK---------QKVLKM---IFTIVLVFWA 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  278 CSVPYAT---LVVYQTVLNVPD---TSVFLLLTAvwLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd14999 225 CFLPFWIwqlLYLYSPSLSLSPrttTYVNYLLTC--LTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
47-329 9.71e-04

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 41.11  E-value: 9.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSL-----LGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVK 121
Cdd:cd15297   1 VFIVLVAGSLslvtiIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGY---WPLGPVVCDLWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FLHKVFCSVTILSFPAIALDRYYSVLYPLERKISD---------AKSRELVMYIWAHAVVASVPVFAVTNVADiyatSTC 192
Cdd:cd15297  78 ALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRttkmagmmiAAAWVLSFILWAPAILFWQFIVGGRTVPE----GEC 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  193 -TEVWSNSlghlvyVLVYNITtvivpvvvvflflilirralsasqkkkviIAALRTPQNTISIPY-----ASQREAELHA 266
Cdd:cd15297 154 yIQFFSNA------AVTFGTA-----------------------------IAAFYLPVIIMTVLYwqisrASSREKKVTR 198
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  267 TLLSMVMVFILCSVPYATLVVYQTVLN--VPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15297 199 TILAILLAFIITWTPYNVMVLINTFCAscIPNT---VWTIGYWLCYINSTINPACYALCNATFKK 260
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
44-329 1.06e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 41.26  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   44 TTTVQVVIFigSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIIlstspHCCWWIYTM--LFCKVVK 121
Cdd:cd15000   4 SMFLPVVLF--GIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLV-----HDFFQNYVLgsVGCKLEG 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADI----YATSTCTE--V 195
Cdd:cd15000  77 FLEGSLLLASVLALCAVSYDRLTAIVLPSEARLTKRGAKIVIVITWIVGLLLALPLAIYRSYRERqwknFLETYCAEntQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  196 WSNSLGH-LVYVLVYnittviVPVVVVFLFLILIRRALSASQKkkviiaALRTPQNTISIPYASQreaeLHATLLSMVMV 274
Cdd:cd15000 157 VLPIYWHvIITVLVW------LPLGIMLICYSAIFWKLDKYER------RVLRREHPSVVRYKKK----AAKTLFIVLIT 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6005772  275 FILCSVPYATLVVYQ-------TVLNVPDTSVFLL-LTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15000 221 FVVCRIPFTALIFYRyklvpndNTQNSVSGSFHILwFASKYLMFLNAAVNPLIYGFTNENFRK 283
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
43-187 1.21e-03

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 40.91  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPhccwWIYTMLFCKVVKF 122
Cdd:cd15179   2 FLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLT-LPFWAVDAAAN----WYFGNFLCKAVHV 76
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  123 LHKV--FCSVTILSFpaIALDRYYSVLYPLERKISDAKSRELVMY--IWAHAVVASVP--VFA-VTNVADIY 187
Cdd:cd15179  77 IYTVnlYSSVLILAF--ISLDRYLAIVHATNSQRPRKLLAEKVVYvgVWLPALLLTVPdlVFAkVSELDDRY 146
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
56-329 1.33e-03

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 40.79  E-value: 1.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   56 LLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCSVTILSF 135
Cdd:cd15309  15 VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGE---WRFSRIHCDIFVTLDVMMCTASILNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  136 PAIALDRYYSVLYPL---ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADiyaTSTCTevwsnsLGHLVYVLVYNIT 212
Cdd:cd15309  92 CAISIDRYTAVAMPMlynTRYSSKRRVTVMISVVWVLSFAISCPLLFGLNNTD---QNECI------IANPAFVVYSSIV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  213 TVIVPVVVVFLFLILIRRALsasqkkkviiaalrtpqntisipyasQREAELHATLLSMVMVFILCSVPYATLVVYQT-- 290
Cdd:cd15309 163 SFYVPFIVTLLVYVQIYIVL--------------------------QKEKKATQMLAIVLGVFIICWLPFFITHILNMhc 216
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6005772  291 VLNVPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15309 217 DCNIPPA---LYSAFTWLGYVNSAVNPIIYTTFNIEFRK 252
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-329 1.40e-03

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 40.99  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTV---FKSVTNRFIKNLACSGICASLVCVP---FDIILSTSPhccwWIYTMLFCK 118
Cdd:cd15355   4 TAIYLALFVVGTVGNSITLYTLARKKSlqhLQSTVHYHLASLALSDLLILLLAMPvelYNFIWVHHP----WAFGDAACR 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  119 VVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERK--ISDAKSRELVMYIWAHAVVASVPVFAVtnVADIYATST----- 191
Cdd:cd15355  80 GYYFLRDACTYATALNVASLSVERYLAICHPFKAKslMSRSRTKKFISAIWLASALLAIPMLFT--MGEQNRSGThpggl 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  192 -CTEVWSNSLghLVYVLVYNittvivpVVVVFLFLILIRRALSASQKKKVII-----------AALRTPQNTISIPYASQ 259
Cdd:cd15355 158 iCTPIVDTST--LKVVIQVN-------AFLSFLFPMLVISVLNTLIANQLTVmvnqaeqenqvCTIGGQRTVLSVSMEPG 228
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  260 REAEL-HATLL--SMVMVFILCSVPY-ATLVVYQTVLNVPDTSV-------FLLLTAVwLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15355 229 RVQSLrHGVLVlrAVVIAFVVCWLPYhVRRLMFCYVSDEQWTTFlydfyhyFYMLTNV-LFYVSSAINPILYNLVSANFR 307

                .
gi 6005772  329 K 329
Cdd:cd15355 308 Q 308
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-177 1.41e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 40.62  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLlGNFMVLWSTCRTTVFKSVTNRF---IKNLACSGICASLVCVPFDIILSTSPHCCWwIYTMLFCKV 119
Cdd:cd15356   3 FTAVYALIWALGAA-GNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLISVPIELYNFVWFHYPW-VFGDLVCRG 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  120 VKFLHKVFCSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPV 177
Cdd:cd15356  81 YYFVRDICSYATVLNIASLSAERYLAICQPLraKRLLSKRRTKWLLALIWASSLGFALPM 140
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
45-176 1.56e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 40.61  E-value: 1.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   45 TTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLH 124
Cdd:cd15127   4 MCLSVVIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKK---WLLGDFSCKIVPYIE 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  125 KVFCSVTILSFPAIALDRYYS-----VLYPLERKISDAKSRELVmyIWAHAVVASVP 176
Cdd:cd15127  81 VASLGVTTFTLCALCIDRFRAatnvqMYYEMIENCTSTTAKLAV--IWVGALLLALP 135
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
47-328 1.94e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 40.06  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKV 126
Cdd:cd15160   6 VYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILT-LPLWIDYTANHHN--WTFGPLSCKVVGFFFYT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLE-RKISDAKSRELV-MYIWA-HAVVASVPVFAVTNVADIYATSTCTEVWSNSlghl 203
Cdd:cd15160  83 NIYASIGFLCCIAVDRYLAVVHPLRfRGLRTRRFALKVsASIWVlELGTHSVFLGHDELFRDEPNHTLCYEKYPME---- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  204 VYVLVYNITTVIVPVVVVFLFLILIRRAlsasqkkkvIIAALRTPQNTisipyASQREAELHATLLSMVMVFILCSVPY- 282
Cdd:cd15160 159 GWQASYNYARFLVGFLIPLSLILFFYRR---------VLRAVRQSPSL-----EREEKRKIIGLLLSIVVIFLLCFLPYh 224
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 6005772  283 -ATLVVYQTVLNVPDTSVF--LLLTA----VWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15160 225 vVLLVRSVIELVQNGLCGFekRVFTAyqisLCLTSLNCVADPILYIFVTEDVR 277
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
43-177 1.99e-03

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 40.21  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKF 122
Cdd:cd15404   2 ILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAVLNMPFALVTIITTR---WIFGDAFCRVSAM 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  123 LHKVFCSVTILSFPAIALDRYYsVLYPLERKISDAKSRELVMYIWAHAVVASVPV 177
Cdd:cd15404  79 FFWLFVMEGVAILLIISIDRFL-IIVQKQDKLNPYRAKVLIAVSWAVSFCVAFPL 132
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
50-194 2.63e-03

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 40.03  E-value: 2.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcVPFDI---ILSTSphccwWIYTMLFCKVVKFLHKV 126
Cdd:cd15159   9 LILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLA-LPGRIayyALGFD-----WPFGDWLCRLTALLFYI 82
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  127 FCSVTILSFPAIALDRYYSVLYPLE----RKISDAKSreLVMYIWAHAVVASVPVFAVTNVADIYATSTCTE 194
Cdd:cd15159  83 NTYAGVNFMTCLSVDRYIAVVHPLRrhrlRKVKVVRY--ICVFVWVLVFLQTLPLLFMPMTKEMGGRITCME 152
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
50-328 2.76e-03

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 39.55  E-value: 2.76e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   50 VIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15299  12 ILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNR---WALGNLACDLWLSIDYVASN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  130 VTILSFPAIALDRYYSVLYPLERKISDAKSRELVM--YIWAHAVVASVPVFAvtnvadiyatstcteVWSNSLGhlvyvl 207
Cdd:cd15299  89 ASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMigLAWVISFVLWAPAIL---------------FWQYFVG------ 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  208 vyNITTVIVPVVVVFLFLILIRRALSasqkkkviIAALRTPQNTISIPY-----ASQREAELHATLLSMVMVFILCSVPY 282
Cdd:cd15299 148 --KRTVPPDECFIQFLSEPIITFGTA--------IAAFYLPVTIMTILYwriykETIKEKKAAQTLSAILLAFIITWTPY 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 6005772  283 ATLVVYQTVLN--VPDTsvfLLLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15299 218 NIMVLVNTFCDscIPKT---YWNLGYWLCYINSTVNPVCYALCNKTFR 262
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
43-328 3.75e-03

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 39.40  E-value: 3.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcasLVCVPFDIILSTSPHCCWWIYTMLFCKVVK- 121
Cdd:cd15370   2 FLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADL---LFVIWFPLKIAYHINGNNWIYGEALCKVLIg 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 -FLHKVFCSvtILSFPAIALDRYYSVLYPLERKISDAKSRELV-MYIWAHAVVASVPVFAVTNVADIYA--TSTCTEVWS 197
Cdd:cd15370  79 fFYGNMYCS--ILFMTCLSVQRYWVIVNPMSHSRKKANIAIGIsLAIWLLILLVTIPLYLVKQTVFIPAldITTCHDVLP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  198 NSLGHL---VYVLVYNITTVIVPVVVVFLFLILIRRALSASqkkkviiaalrtpQNTISIPYASQREAELHATLLSMvmv 274
Cdd:cd15370 157 EQLLVGdmfNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSS-------------INDESIEKKRKRAIKLIVTVLVM--- 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6005772  275 FILCSVPYATLVV--YQTVLNVPDTSVF-LLLTAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15370 221 YLICFTPSNLLLVvhYFLLKNQGQSSVYaFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
43-329 3.92e-03

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 39.23  E-value: 3.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLAcsgiCASLVCVPFDIILSTSPHC-CWWIYTMLFCKVVK 121
Cdd:cd15298   2 FIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLA----CADLIIGAFSMNLYTVYIIkGYWPLGAVVCDLWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FLHKVFCSVTILSFPAIALDRYYSVLYPLE---RKISD------AKSRELVMYIWAHAVVASVPVFAVTNVADiyatstc 192
Cdd:cd15298  78 ALDYVVSNASVMNLLIISFDRYFCVTKPLTypaRRTTKmaglmiAAAWVLSFVLWAPAILFWQFVVGKRTVPD------- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  193 tevwsnslGHLVYVLVYNITTVIVPVVVVFLFLILIRRALsasqkkkviiaalrtpqnTISIPYASQREAELHATLLSMV 272
Cdd:cd15298 151 --------NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVL------------------YIHISLASARERKVTRTIFAIL 204
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6005772  273 MVFILCSVPYATLVVYQTVLN--VPDTSVFLlltAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15298 205 LAFILTWTPYNVMVLVNTFCQscIPDTVWSI---GYWLCYVNSTINPACYALCNATFKK 260
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
43-185 4.49e-03

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 39.00  E-value: 4.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGN---FMVLWSTCRTTvfKSVTNRFIKNLACSGICAsLVCVPFDIIlSTSPHccwWIYTMLFCKV 119
Cdd:cd15188   2 FLPVFYTLVFLLGLAGNlllFVVLLLYVPKK--KKMTEVYLLNLAVSDLLF-LVTLPFWAM-YVAWH---WVFGSFLCKF 74
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6005772  120 VKFLHKVFCSVTILSFPAIALDRYYSVLY--PLERKISDAKSRELVMYIWAHAVVASVPVFAVTNVAD 185
Cdd:cd15188  75 VSTLYTINFYSGIFFVSCMSLDKYLEIVHaqSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHH 142
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
43-329 4.65e-03

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 38.98  E-value: 4.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCrTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPHccWWIYTMLFCKVVKF 122
Cdd:cd15116   2 LSMVIYSVVFVLGVLGNGLVIFITG-FKMKKTVNTVWFLNLAVADFLFTFF-LPFSIAYTAMDF--HWPFGRFMCKLNSF 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 L--HKVFCSVTILSfpAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSN 198
Cdd:cd15116  78 LlfLNMFTSVFLLT--VISIDRCISVVFPVwsQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICFNNF 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  199 SLGHlvyvlVYNITTVIVPVVVVFLFLILIRRALSASQKKKVIIA-----ALRTPQNTISipyasqREAELHATLLSMVM 273
Cdd:cd15116 156 SLSG-----DNSSPEVNQLRNMRHQVMTITRFLLGFLIPFTIIICcyaaiVLKLKRNRLA------KSSKPFKIIAAVIV 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005772  274 VFILCSVPYATLVVYQTVLNVPDTSVFllltAVWLPKVSLLA------NPVLFLTVNKSVRK 329
Cdd:cd15116 225 TFFLCWAPYHILNLLEMEATRSPASVF----KIGLPITSSLAfinsclNPILYVFMGQDFKK 282
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
42-331 4.73e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 39.01  E-value: 4.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   42 QFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVcvPFDIILSTSPHCcWWIYTMLFCKVVK 121
Cdd:cd15082  14 TVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLT--GGTISFLTNARG-YFFLGVWACVLEG 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  122 FLHKVFCSVTILSFPAIALDRYYSVLYPLERKISDAKSREL-VMYIWAHAVVASVP-VFAVTNVADIYATSTCTEVW-SN 198
Cdd:cd15082  91 FAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQGKHAALgLLFVWTFSFIWTIPpVLGWSSYTVSKIGTTCEPNWySG 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  199 SLGHLVYVLVYnittvivpVVVVFLFLILIrraLSASQKKkvIIAALRTPQNTiSIPYASQREAELHATLLSMVMV--FI 276
Cdd:cd15082 171 NMHDHTYIITF--------FTTCFILPLGV---IFVSYGK--LLQKLRKVSNT-QGRLGNARKPERQVTRMVVVMIvaFM 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  277 LCSVPYATLVVYQTVLNVPDTSVFLLLTAVWLPKVSLLANPVLFLTVNKSVRKCL 331
Cdd:cd15082 237 VCWTPYAAFSILVTAHPTIHLDPRLAAIPAFFSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
49-331 4.86e-03

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 39.11  E-value: 4.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   49 VVIFIGsLLGNFMVLW-STCRTTVFKSVTNRFIKNLACSGICASLVcVPFDIILSTSPHCcwWIYTMLFCKVVKFLHKVF 127
Cdd:cd15926   9 VVCALG-LVGNLLVLYlMKSKQGWKKSSINLFVTSLAVTDFQFVLT-LPFWAVENALDFT--WLFGKAMCKIVSYVTAMN 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  128 CSVTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFAVTNVADIYATSTCTEVWSNSLGHLVY 205
Cdd:cd15926  85 MYASVFFLTAMSVARYHSVASALksKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRGNAQF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  206 VLVYNITTVIVPVVVVFLFLILIRRALsasqkkkviiaALRTPQNTISIPYASQREAELHATLLSMVMVFILCSVPYATL 285
Cdd:cd15926 165 WLGLYHAQKVLLGFLIPLGIISLCYLL-----------LVRFITDKNITGSSTKRRSKVTKSVTIVVLSFFLCWLPNQAL 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  286 VVYQTV--LNVPDTSVFLLLTAVWLPKVSL-LA------NPVLFLTVNKSVRKCL 331
Cdd:cd15926 234 TTWGILikLNVVHFSYEYFTTQVYIFPITVcLAhsnsclNPILYCLMRREFRKAL 288
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
47-150 4.96e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 39.01  E-value: 4.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   47 VQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLvcvpFDIIlstsPHCCWWIY-----TMLFCKVVK 121
Cdd:cd15386   6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVAL----FQVL----PQLIWEITyrfqgPDLLCRAVK 77
                        90       100       110
                ....*....|....*....|....*....|.
gi 6005772  122 FLHKV--FCSVTILSfpAIALDRYYSVLYPL 150
Cdd:cd15386  78 YLQVLsmFASTYMLI--MMTVDRYIAVCHPL 106
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
52-179 5.79e-03

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 38.63  E-value: 5.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   52 FIGsLLGNFMVLWSTC--RTTVFKSVTNRFIKNLACSGiCASLVCVPFDIILSTSPHccwWIYTMLFCKVVKFLHKVFCS 129
Cdd:cd15122  12 LLG-LPGNGFIIWSILwkMKARGRSVTCILILNLAVAD-GAVLLLTPFFITFLTRKT---WPFGQAVCKAVYYLCCLSMY 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6005772  130 VTILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVASVPVFA 179
Cdd:cd15122  87 ASIFIIGLMSLDRCLAVTRPYlaQSLRKKALVRKILLAIWLLALLLALPAFV 138
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
41-285 5.81e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 38.83  E-value: 5.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   41 RQFTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKS-VTNRFIKNLACSGICASLVCVPFDIILSTSPhccWWIYTMlFCKV 119
Cdd:cd15320   1 RVLTGCFLSVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAVLVMPWKAVAEIAG---FWPFGS-FCNI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  120 -VKFlhKVFCSV-TILSFPAIALDRYYSVLYPL--ERKISDAKSRELVMYIWAHAVVAS-VPV------FAVTNVADIYA 188
Cdd:cd15320  77 wVAF--DIMCSTaSILNLCVISVDRYWAISSPFryERKMTPKVAFIMISVAWTLSVLISfIPVqlnwhkAKPTSFLDLNA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  189 TS--TCTEVWSNSLGHLVYVlvynITTVIVPVVVVFLFLILIRRALSASQKKKVIIAAL-------RTPQNTI------- 252
Cdd:cd15320 155 SLrdLTMDNCDSSLNRTYAI----SSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALeraavhaKNCQNSTgnrgsgd 230
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 6005772  253 ------SIPYASQREAELHATLLSMVMVFILCSVPYATL 285
Cdd:cd15320 231 cqqpesSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFIL 269
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
55-167 5.92e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 38.57  E-value: 5.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   55 SLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGICASLVCVPFDIILSTSPHccWWIYTMLFCKVVKFLHKVFCSVTILS 134
Cdd:cd15302  14 TVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNGD--YWPLGWVLCDLWLSVDYTVCLVSIYT 91
                        90       100       110
                ....*....|....*....|....*....|....*
gi 6005772  135 FPAIALDRYYSVLYPLERKI--SDAKSRELVMYIW 167
Cdd:cd15302  92 VLLITIDRYCSVKIPAKYRNwrTPRKVLLIIAITW 126
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
53-187 6.17e-03

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 38.63  E-value: 6.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   53 IGSLLG---NFMVLWST-CRttVFKSVTNRFIKNLACSGICASLvCVPFDIILSTSPHCcwWIYTMLFCKVVK--FLHKV 126
Cdd:cd15118   9 IVSTLGiveNLLILWVVgFR--LRRTVISIWILNLALSDLLATL-SLPFFTYYLASGHT--WELGTTFCRIHSsiFFLNM 83
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005772  127 FCSVTILSfpAIALDRYYSVLYPL----ERKISDAKsrELVMYIWAHAVVASVPVFAVTNVADIY 187
Cdd:cd15118  84 FVSGFLLA--AISLDRCLLVVKPVwaqnHRNVAAAK--KICGVIWAMALINTIPYFVFRDVIERK 144
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
43-328 6.34e-03

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 38.62  E-value: 6.34e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSG---ICAslvcVP--FDIILstspHCCWWIYTMLFC 117
Cdd:cd15366   2 FPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDllyIAT----LPlwIDYFL----HRDNWIHGPESC 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  118 KVVKFLHKVFCSVTILSFPAIALDRYYSVLYPLE----RKISDAKSRELVmyIWAHAVVA-SVPVFAVTNVADIYATSTC 192
Cdd:cd15366  74 KLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRfakvRRVKTAVAVSAV--VWAIEIGAnSAPLFHDELFRDRYNHTFC 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  193 TEVWSNSLGhlvyVLVYNITTVIVPVVVVFLFLILIRRAlsasqkkkvIIAALRTpqntiSIPYASQREAELHATLLSMV 272
Cdd:cd15366 152 FEKYPMEDW----VAWMNLYRVFVGFLFPWVLMLFSYRG---------ILRAVRG-----NVSTEQQEKAKIKRLALSLI 213
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  273 MVFILCSVPYATLVVYQTV--LNVP-----DTSVFLLL-TAVWLPKVSLLANPVLFLTVNKSVR 328
Cdd:cd15366 214 AIVLLCFAPYHVLLLSRSVvyLGKPcdcgfEERVFTAYhVSLALTSLNCVADPILYCLVNEGAR 277
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
43-291 7.18e-03

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 38.58  E-value: 7.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   43 FTTTVQVVIFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcASLVCVPFDIILSTSPhccwWIYTMLFCKVVKF 122
Cdd:cd15181   2 FIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADL-LLLLTFPFSVVESIAG----WVFGTFLCKLVGA 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  123 LHKV--FCSVTILSfpAIALDRYYSVLYplerKISDAKSRELV------MYIWAHAVVASVPVFAVTNVADIYATSTCTE 194
Cdd:cd15181  77 IHKLnfYCSSLLLA--CISVDRYLAIVH----AIHSYRHRRLRsvhltcGSIWLVCFLLSLPNLVFLEVETSTNANRTSC 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  195 VWSNSLGHLVYVLVyniTTVIVPVVVVFLFLILIRRALSASqkkkvIIAALRTPQNTIsipyasQREAELHATLLsMVMV 274
Cdd:cd15181 151 SFHQYGIHESNWWL---TSRFLYHVVGFFLPLLIMGYCYAT-----IVVTLCQSSRRL------QKQKAIRVAIL-VTLV 215
                       250
                ....*....|....*..
gi 6005772  275 FILCSVPYATLVVYQTV 291
Cdd:cd15181 216 FCLCWLPYNIVIFLDTL 232
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
51-329 8.88e-03

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 38.20  E-value: 8.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   51 IFIGSLLGNFMVLWSTCRTTVFKSVTNRFIKNLACSGIcASLVCVPFDIILSTSPHccWWIYTMLFCKVVKFL--HKVFC 128
Cdd:cd15088  10 ICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADL-LFMLGMPFLIHQFAIDG--QWYFGEVMCKIITALdaNNQFT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  129 SVTILSfpAIALDRYYSVLYPLE----RKISDAKSRELVmyIWAHAVVASVPVFAVTNVadIY---ATSTCTEVWSNSLG 201
Cdd:cd15088  87 STYILT--AMSVDRYLAVVHPIRstkyRTRFVAKLVNVG--LWAASFLSILPVWVYSSL--IYfpdGTTFCYVSLPSPDD 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772  202 HLVYVLVYNITTVIVPVVVVFLFLILIRRALSASqkkkviiAALRTPQNtisipyASQREAELHATLLSMVMVFILCSVP 281
Cdd:cd15088 161 LYWFTIYHFILGFAVPLVVITVCYILILHRLARG-------VAPGNQSH------GSSRTKRVTKMVILIVVVFIVCWLP 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 6005772  282 YATLVVYQTVLNVPDTS-VFLLLTAVWLPKVSLLANPVLFLTVNKSVRK 329
Cdd:cd15088 228 FHVVQLVNLAMNRPTLAfEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
46-178 9.44e-03

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 38.08  E-value: 9.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005772   46 TVQVVIFIGSLLGNFMVLWSTCRttvfksvtnrFIKNLACSGICAS---------LVCVPFDIILSTSPhccwWIYTMLF 116
Cdd:cd15165   5 VVYIPTFVLGLLLNLMALWVFLF----------KIKKWTESTIYMInlalndlllLLSLPFKMHSSKKQ----WPLGRTL 70
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005772  117 CKVVKFLHKVFCSVTILSFPAIALDRYYSVLYPLERKI--SDAKSRELVMYIWAHAVVASVPVF 178
Cdd:cd15165  71 CSFLESLYFVNMYGSILIIVCISVDRYIAIRHPFLAKRlrSPRKAAIVCLTIWVFVWAGSIPIY 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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