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Conserved domains on  [gi|599412849|gb|AHN62586|]
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olfactory receptor family 51, partial [Vampyrum spectrum]

Protein Classification

olfactory receptor family 51 protein( domain architecture ID 11607012)

olfactory receptor family 51 protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
1-238 1.98e-141

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320350  Cd Length: 275  Bit Score: 396.87  E-value: 1.98e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15222   31 LHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYAS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15222  111 ILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15222  191 LLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIY 268
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
1-238 1.98e-141

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 396.87  E-value: 1.98e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15222   31 LHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYAS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15222  111 ILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15222  191 LLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIY 268
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
1-238 1.22e-84

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 253.19  E-value: 1.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849    1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:pfam13853  25 LHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTT 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:pfam13853 105 ILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLI 184
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849  161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:pfam13853 185 VLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQIMMANAYLFFPPVLNPIVY 262
 
Name Accession Description Interval E-value
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
1-238 1.98e-141

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 396.87  E-value: 1.98e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15222   31 LHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFMESSVLLAMAFDRFVAICNPLRYAS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15222  111 ILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15222  191 LLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFYVPMIGLSMVHRFGKHASPLVHVLMANVYLLVPPVLNPIIY 268
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
1-238 4.21e-103

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 299.97  E-value: 4.21e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15917   31 LHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAMESGVLLAMAFDRYVAICYPLRYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15917  111 ILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACGDTRVNSIYGLFVALLIVGFDLLFI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15917  191 ALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHVPPHVHILLANLYLLLPPMLNPIVY 268
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
1-238 1.19e-92

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 273.45  E-value: 1.19e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15951   31 LHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTMESGIFVAMALDRYVAICNPLRHST 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15951  111 ILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACADTRVSRAYGLSVAFLVGGLDVIFI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15951  191 AVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNVPPHVHILIANVYLLVPPMLNPIIY 268
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
1-238 3.81e-92

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 271.83  E-value: 3.81e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15953   31 LHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIMESAVLVAMAFDRYVAICNPLRYAT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15953  111 ILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACGDTTINRIYGLVVALLVVGLDLLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15953  191 ALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLTHRFGQGIAPHIHIILANLYLLVPPMLNPIIY 268
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
1-238 4.56e-92

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 271.86  E-value: 4.56e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15221   31 LHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVTESAILLAMAFDRYVAICYPLRYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15221  111 ILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACADITVNIWYGLTVALLTVGLDVVLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15221  191 AVSYALILRAVFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFLTHRFGRHIPRHVHILLANLYVLVPPMLNPIVY 268
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
1-238 3.12e-89

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 264.66  E-value: 3.12e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15950   31 LHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFTAVESGVLLAMAFDRYVAICHPLRYSA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15950  111 ILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLACADPRPSSLYSITGSTLVVGTDSAFI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15950  191 AVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLSIYTQRFGQGVPPHTQVLLADLYLLVPPMLNPIIY 268
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
1-238 8.63e-89

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 263.69  E-value: 8.63e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15948   32 LHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIMESAVLLAMAFDRYVAICNPLRYAT 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15948  112 ILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFI 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15948  192 ILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTMHRFARHVAPHVHILLANFYLLFPPMMNPIVY 269
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
1-238 1.24e-85

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 255.38  E-value: 1.24e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15952   31 LHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGMESAVLVAMAFDRYVAICNPLRYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINsAVGLTALITTAGVDSVFI 160
Cdd:cd15952  111 ILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACASIRIN-IIYGLFAISVLVLDVILI 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15952  190 ALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNIPRYIHILLANLYVVLPPMLNPVIY 267
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
1-238 1.22e-84

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 253.19  E-value: 1.22e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849    1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:pfam13853  25 LHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAVLLAMAVDRFVAICSPLRYTT 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:pfam13853 105 ILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKVNNIYGLFVVTSTFGIDSLLI 184
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849  161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:pfam13853 185 VLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVHRFGHNVPPLLQIMMANAYLFFPPVLNPIVY 262
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
1-238 5.73e-80

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 241.04  E-value: 5.73e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15223   31 LHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFFTAMESSILLVMALDRYVAICKPLRYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15223  111 IITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSLACGDTTINSIYGLAVAWLIVGSDIILI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15223  191 FFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLTYRFGKTIPPDVHVLLSVLYILIPPALNPIIY 268
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
1-238 2.36e-77

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 235.06  E-value: 2.36e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15949   47 LHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSSNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKT 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15949  127 ILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWYRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFI 206
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15949  207 VLSYIMILRVVQRLATSEARLKTFGTCVSHVCAILAFYVPIAVSSLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVY 284
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
1-238 2.75e-74

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 226.67  E-value: 2.75e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15956   31 LHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFSAMESGVLVAMALDRFVAICNPLHYAT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15956  111 ILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLACGATTVDSLYGLALALFIGGGDVLFI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15956  191 AYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLMHRFGHSVPSAAHVLLSNLYLLLPPALNPIVY 268
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
1-238 7.79e-72

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 220.41  E-value: 7.79e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15955   31 LHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQAFESGILLAMALDRYVAICHPLRHSS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLK-RLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVF 159
Cdd:cd15955  111 ILTPQVLLGIGVLVVVRAVVLIIPCPLLIKlRLHHFRSTVISHSYCEHMAVVKLAADDVRVNKIYGLFVAFSILGFDIIF 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412849 160 IILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15955  191 ITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHHVAPYVHILLSNLYLLVPPVLNPIVY 269
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
1-238 3.83e-71

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 218.54  E-value: 3.83e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15954   31 LHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGMESGVLMLMALDRYVAICYPLRYAT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15954  111 ILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLACANIRVDAIYGLMVALLIGGFDILCI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRF-GKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15954  191 SVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRFgGHHITPHIHIIMANLYLLLPPMMNPIVY 269
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-238 1.88e-57

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 183.45  E-value: 1.88e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd13954   31 LHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSLGGTECFLLAVMAYDRYVAICHPLHYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd13954  111 IMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKLSCSDTSLNELVIFILAGFVGLGSFLLT 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFihRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd13954  191 LVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYV--RPSSSYSSDLDKVVSVFYTVVTPMLNPIIY 266
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
1-206 3.74e-47

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 157.38  E-value: 3.74e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15235   32 LHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFIAFGNTDSFLLAVMAYDRYVAICHPLHYAT 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15235  112 VMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLLKLSCSDTSLNELLIFTEGAVVVLGPFLLI 191
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSF 206
Cdd:cd15235  192 VLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYF 237
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
1-202 3.14e-46

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 154.59  E-value: 3.14e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15230   31 LHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVFGTTECFLLAAMAYDRYVAICNPLLYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVgLTALITTAGVDSVFI 160
Cdd:cd15230  111 IMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKLSCSDTHINELV-LFAFSGFIGLSTLLI 189
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 599412849 161 IL-SYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLI 202
Cdd:cd15230  190 ILiSYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLI 232
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
1-198 3.35e-44

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 149.53  E-value: 3.35e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15225   31 LHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFLFLGGTECFLLAAMAYDRYVAICNPLRYTL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15225  111 IMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVLKLACADTSLNEIAIFVASVLVILVPFLLI 190
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15225  191 LVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFY 228
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
1-238 4.14e-44

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 149.30  E-value: 4.14e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15918   31 LHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLFGDLDNFLLAVMAYDRYVAICHPLHYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15918  111 IMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKLSCSDTHLNELVILVLGGLVGLVPFLCI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIhrfgkeaPPYVH-----TLIANACLLIPPVMNP 235
Cdd:cd15918  191 LVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLS-------PPSSHsaskdSVAAVMYTVVTPMLNP 263

                 ...
gi 599412849 236 VVY 238
Cdd:cd15918  264 FIY 266
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
1-238 2.91e-42

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 144.71  E-value: 2.91e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15231   31 LHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVSFVGTECLLLAVMAYDRYVAICNPLHYAV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15231  111 IMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLKLSCSDTSLNEVLLLVASVFIGLTPFLFI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIsLSFIhRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15231  191 VISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAI-FNYN-RPSSGYSLDKDTLISVLYSIVTPMLNPIIY 266
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
1-238 6.43e-42

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 143.69  E-value: 6.43e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15412   31 LHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFFIALVITEYYMLAVMAYDRYMAICNPLLYSV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSavglTALITTAGVD---S 157
Cdd:cd15412  111 KMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPLIKLSCSDTYVKE----TAMFIVAGFNlssS 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 158 VFIIL-SYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFihrfgkeAPPYVHTL-----IANACLLIPP 231
Cdd:cd15412  187 LLIILiSYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYL-------RPPSEESVeqskiVAVFYTFVSP 259

                 ....*..
gi 599412849 232 VMNPVVY 238
Cdd:cd15412  260 MLNPLIY 266
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
1-238 1.49e-41

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 142.51  E-value: 1.49e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15914   31 LHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSLGITECYLLTAMAYDRYLAICNPLHYPS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAV-----GLTALITTAgv 155
Cdd:cd15914  111 IMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSLACTDTSLNVLVdfvihAVIILLTFL-- 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 156 dsvFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYiplISLSFIH-RFGKEAPPYVHTLIANACLLIPPVMN 234
Cdd:cd15914  189 ---LILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFF---GSVSFMYlRLSKSYSLDYDRAIAVVYAVLTPFFN 262

                 ....
gi 599412849 235 PVVY 238
Cdd:cd15914  263 PIIY 266
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
1-238 9.08e-41

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 140.67  E-value: 9.08e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGlSISTLV--TMLGIFWfNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRY 78
Cdd:cd15227   31 LHTPMYFFLKNLSFLDLC-YISVTVpkSIANSLT-NTRSISFLGCVAQVFLFIFFAASELALLTVMAYDRYVAICHPLHY 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  79 ASILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSV 158
Cdd:cd15227  109 EVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKLSCSDTYLNEIGVLVLSVCLGLGCFV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 159 FIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYiplISLSFIH-RFGKEAPPYVHTLIANACLLIPPVMNPVV 237
Cdd:cd15227  189 FIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFL---STGSFAYlKPPSDSPSLLDLLLSVFYSVVPPTLNPII 265

                 .
gi 599412849 238 Y 238
Cdd:cd15227  266 Y 266
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
1-238 2.94e-40

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 139.76  E-value: 2.94e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15408   44 LHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKVISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTV 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSA-----VGLTALITTagv 155
Cdd:cd15408  124 IMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGSNVINHFFCDGPPLLALSCSDTSLNEMllfafVGFNVLTTT--- 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 156 dsVFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYiplISLSFIhrFGKEAPPYVHTLIANACLL---IPPV 232
Cdd:cd15408  201 --LVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLFY---GSLAFM--YLRPSSRYSLDLDKVASVFytvVIPM 273

                 ....*.
gi 599412849 233 MNPVVY 238
Cdd:cd15408  274 LNPLIY 279
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
1-238 2.11e-39

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 137.79  E-value: 2.11e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15410   44 LHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTV 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15410  124 IMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLII 203
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIhrfgkeaPPYVHTLIANACL-----LIPPVMNP 235
Cdd:cd15410  204 LTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIFHGTILFMYCR-------PSSSYSLDTDKVAsvfytVVIPMLNP 276

                 ...
gi 599412849 236 VVY 238
Cdd:cd15410  277 LIY 279
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
1-238 2.55e-39

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 136.62  E-value: 2.55e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15232   31 LHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWSLGSELLLLTAMAYDRYVAICHPLHYST 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15232  111 IMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLLSCSDTSLNEIMAFVADVFFGVGNFLLT 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIsLSFIhRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15232  191 LTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVI-YTYI-RPSSSYSPEKDKVVAVLYSVVTPTLNPLIY 266
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
1-238 2.69e-39

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 137.06  E-value: 2.69e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15411   31 LHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIALATTECFLLGLMAYDRYVAICNPLLYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15411  111 VMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLKLSCSDTHVNEMLIFILAGLTLVGSLLII 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLI------SLSFIHRFGKEAPPYVHTLIanacllipPVMN 234
Cdd:cd15411  191 LVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIftylrpSSSYSLGQDKVASVFYTVVI--------PMLN 262

                 ....
gi 599412849 235 PVVY 238
Cdd:cd15411  263 PLIY 266
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
1-198 2.72e-39

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 136.96  E-value: 2.72e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15229   31 LHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFFAGTEAFLLSAMAYDRYAAICHPLHYVQ 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15229  111 IMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPLSCSDTFANKMVLLTSSVIFGLGSFLLT 190
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15229  191 LVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFY 228
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
1-198 3.78e-39

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 136.62  E-value: 3.78e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15417   31 LHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGMGLTECFLLAAMAYDRYVAICNPLLYSV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15417  111 IMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSLSCSDTFISQVVLFLVAVLFGVFSVLVV 190
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15417  191 LISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFY 228
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
1-198 5.25e-39

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 136.72  E-value: 5.25e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15943   45 LHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTV 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15943  125 IMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEI 204
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15943  205 LVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTIFY 242
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
1-238 1.00e-38

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 135.51  E-value: 1.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15419   31 LHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFSLFGTTEGFLLAAMAYDRFIAICNPLLYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAV--GLTALI--TTAGVd 156
Cdd:cd15419  111 IMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLLKLSCSDTFINELVmfVLCGLIivSTILV- 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 157 svfIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYiplISLSFIH-RFGKEAPPYVHTLIANACLLIPPVMNP 235
Cdd:cd15419  190 ---ILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFY---GTVFFMYaQPGAVSSPEQSKVVSVFYTLVIPMLNP 263

                 ...
gi 599412849 236 VVY 238
Cdd:cd15419  264 LIY 266
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
1-198 1.03e-38

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 135.30  E-value: 1.03e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15912   31 LHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYFFLGTTEFFLLAVMSFDRYVAICNPLHYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15912  111 IMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLLKLSCSDTRLIELLDFILASVVLLGSLLLT 190
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15912  191 IVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFY 228
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
1-203 1.74e-38

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 134.66  E-value: 1.74e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15431   31 LHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFLGITECLLLAVMAYDRFVAICNPLRYTL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITrGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15431  111 IMSWRVCIQLAAGSWV-SAFLLTVIPVLTMPLHFCGPNVINHFFCEVQALLKLACSDTSLNEILMFATSIFTLLLPFSFI 189
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIS 203
Cdd:cd15431  190 LVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIF 232
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
1-206 2.53e-38

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 134.80  E-value: 2.53e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15406   40 LHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYPECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNV 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15406  120 TMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVINHYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAI 199
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSF 206
Cdd:cd15406  200 LISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSIIFMYL 245
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
1-238 3.05e-38

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 134.24  E-value: 3.05e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15234   31 LHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLFGGLDNFLLAVMAYDRYVAICHPLHYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQ---IGVAIITRGTLILTPMVLllkRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDS 157
Cdd:cd15234  111 IMNPCLCGLlvlLSLLISILDSLLHSLMVL---QLSFCTDVEIPHFFCELAQVLKLACSDTLINNILIYLATVIFGGIPL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 158 VFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY----IPLISLSFIHRFGKEAPPYVhtlianACLLIPPVM 233
Cdd:cd15234  188 SGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYgtglGVYISSAVTHSSRKTAVASV------MYTVVTPML 261

                 ....*
gi 599412849 234 NPVVY 238
Cdd:cd15234  262 NPFIY 266
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
1-238 3.71e-37

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 131.07  E-value: 3.71e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15911   31 LHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSLAATECYLLAVMSYDRYLAICKPLHYAS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15911  111 LMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKLSCSDTSLVELVTFILSSIVTLPPFLLT 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRfgKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15911  191 LTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPS--TNTSRDLNKVFSLFYTVLTPLVNPLIY 266
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
1-238 4.97e-37

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 130.86  E-value: 4.97e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15237   31 LHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLALGVTECVLLAVMAYDRYVAICNPLRYSV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15237  111 IMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKLACADTSLNEAVIFVTSVLVLLIPFSLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKeaPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15237  191 LASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTH--SPDQDKMISVFYTIVTPMLNPLIY 266
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
1-238 9.78e-37

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 130.22  E-value: 9.78e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15409   31 LHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFSATTECFLLAAMAYDRYVAICNPLLYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15409  111 VMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKISCTDPSINELVLFIFSGSIQVFTILTV 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPpyvHTLIANACL-LIPPVMNPVVY 238
Cdd:cd15409  191 LISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYALD---QDMMDSLFYtIVIPLLNPFIY 266
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
1-238 2.46e-36

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 129.46  E-value: 2.46e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15415   31 LHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVFVTTEGFLLAVMAYDRYVAICNPLLYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15415  111 AMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKLSCSDTHINELLLLTFSGVIAMSTLLTI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPlISLSFIHrfgkeaPPYVHTL-----IANACLLIPPVMNP 235
Cdd:cd15415  191 IISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGS-VSFSYIQ------PSSQYSLeqekvSAVFYTLVIPMLNP 263

                 ...
gi 599412849 236 VVY 238
Cdd:cd15415  264 LIY 266
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
1-198 5.96e-36

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 128.21  E-value: 5.96e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15420   31 LHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLALAHTECVLLAVMSYDRYVAICHPLRYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15420  111 IMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKLACADTWINEILIFAGCVFILLGPFSLI 190
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15420  191 LISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFY 228
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
1-238 7.57e-36

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 127.78  E-value: 7.57e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15224   31 LHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSLACTECVLLAVMAYDRYVAICHPLRYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVG-LTALITTAGVDSVf 159
Cdd:cd15224  111 IMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNLSCTDMSLAELVDfILALIILLVPLLV- 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 160 IILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsFIHRFGKEAPPY-VHTLIANACLLIPPVMNPVVY 238
Cdd:cd15224  190 TVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATL---FMYARPKAISSFdSNKLVSVLYTVVTPLLNPIIY 266
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
1-238 1.32e-35

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 127.16  E-value: 1.32e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15228   31 LHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFLGSTECLLYTVMAYDRYVAICHPLRYLL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15228  111 IMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKLACADTSIAETVSFTNVGLVPLTCFLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIsLSFIHRfgkEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15228  191 LASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCA-LIYTQP---TPSPVLVTPVQIFNNVVTPMLNPLIY 264
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
1-238 1.56e-35

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 127.16  E-value: 1.56e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15424   31 LHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALSLGSTECLLLGAMAYDRYLAICHPLLYAA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15424  111 AMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLKLACADTHITEAIVFGAGVLILLVPLSVI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGkeAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15424  191 LTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSG--STPDRDKQIAVFYIVITPLLNPIIY 266
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
1-238 1.85e-35

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 127.15  E-value: 1.85e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15407   31 LHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVFATVENFLLASMAYDRHAAVCKPLHYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15407  111 TMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLALSCSDIHISEIVLFFLASFNVFFALLVI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsfihrFGKEAPPYVHTLIANACL-----LIPPVMNP 235
Cdd:cd15407  191 LISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVI-------FMYLQPSSSHSMDTDKMAsvfytMVIPMLNP 263

                 ...
gi 599412849 236 VVY 238
Cdd:cd15407  264 LVY 266
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
1-201 3.33e-35

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 126.39  E-value: 3.33e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15414   31 LHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLFVAAECFLLASMAYDRYVAICNPLLYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15414  111 IMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSLSCADTQINKWVLFIMAGALGVLSGLII 190
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPL 201
Cdd:cd15414  191 LVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTL 231
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
1-238 3.97e-35

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 125.88  E-value: 3.97e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15915   31 LHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFLGSSEAMLLAVMAYDRYVAICNPLRYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAV--GLTALITTAGvdSV 158
Cdd:cd15915  111 IMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKLACGDTSLNLWLlnIVTGSIALGT--FI 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 159 FIILSYILIIKTVLSIA-SPEERKKAFSTCISHIGAVAVFYIPLIsLSFIHRFGKEAPPYvHTLIANACLLIPPVMNPVV 237
Cdd:cd15915  189 LTLLSYIYIISFLLLKVrSKEGRHKAFSTCASHLTVVLLLYGPAL-FTYIRPSSGDSLEQ-DRIVALLYTVVTPVLNPLI 266

                 .
gi 599412849 238 Y 238
Cdd:cd15915  267 Y 267
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
1-238 7.70e-35

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 125.51  E-value: 7.70e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15413   31 LQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTFIISELFLLSAMAYDRYVAICNPLLYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVgltaLITTAGVDSVF- 159
Cdd:cd15413  111 IMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLALSCSDTHEKELI----ILIFAGFNLISs 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 160 ---IILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsfihrFGKEAPPYVHTLIANAC-----LLIPP 231
Cdd:cd15413  187 lliVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLI-------FMYLQPKSSHSLDTDKMasvfyTLVIP 259

                 ....*..
gi 599412849 232 VMNPVVY 238
Cdd:cd15413  260 MLNPLIY 266
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
1-238 9.58e-35

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 125.27  E-value: 9.58e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15236   31 LHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFFGCLDSFLLAVMAYDRYVAICHPLHYTA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15236  111 IMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKLSCSSTSLNELVIFTEGGLLFVLPLLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIANAclLIPPVMNPVVY 238
Cdd:cd15236  191 LGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNSSDKDIVASVMYT--VVTPMLNPFIY 266
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
1-238 1.31e-34

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 124.58  E-value: 1.31e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15421   31 LHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTLGGAECLLLALMAYDRYVAICHPLRYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGT---LILTPMVLllkRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDS 157
Cdd:cd15421  111 LMSPRVCLLMAAGSWLGGSlnsLIHTVYTM---HFPYCGSREIHHFFCEVPALLKLSCADTSAYETVVYVSGVLFLLIPF 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 158 VFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsFIH-RFGKEAPPYVHTLIANACLLIPPVMNPV 236
Cdd:cd15421  188 SLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAI---FTYmRPGSYHSPEQDKVVSVFYTILTPMLNPL 264

                 ..
gi 599412849 237 VY 238
Cdd:cd15421  265 IY 266
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
1-238 1.61e-33

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 122.16  E-value: 1.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15945   44 LHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKSIPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTT 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15945  124 AMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGSNTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAI 203
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFihRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15945  204 IISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLFYGTLLFMYL--RPSSSYSLDTDKMTSVFYTLVIPMLNPLIY 279
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
1-238 6.17e-33

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 120.25  E-value: 6.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTML-GIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYA 79
Cdd:cd15916   31 LHRPMYIFLGHLSFLDMWLSTVTVPKMLaGFLEPGGKVISFGGCVAQLYFFHFLGSTECFLYTLMAYDRYLAICHPLHYP 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  80 SILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVF 159
Cdd:cd15916  111 TIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLKLACADTTINELVIFASIGVVALGCFIL 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 160 IILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsFIH-RFGKEAPpyVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15916  191 ILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCV---FIYlRPGSKEA--LDGVIAVFYTVVTPLLNPLIY 265
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
1-238 1.02e-32

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 119.81  E-value: 1.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15429   31 LHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLALGGTEFILLAVMAYDRYVAVCHPLRYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15429  111 IMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRLACVDTSLNEVAILVSSVVVLLTPCFLV 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGkeAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15429  191 LLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSG--SSALQEKMISLFYAVVTPMLNPLIY 266
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
1-198 1.33e-32

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 119.39  E-value: 1.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15416   31 LHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATFGTVECFLLAAMAYDRYVAICNPLLYST 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15416  111 IMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKLSCSDIRLAKILPSISSGIIILVTVLTI 190
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15416  191 IISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFY 228
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
1-238 1.83e-32

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 119.01  E-value: 1.83e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15430   31 LHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLAMGSTECVLLAVMAYDRYVAICNPLRYPI 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15430  111 IMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLKLACVDISLNEIIMLVGNIIFLVIPLLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEapPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15430  191 CISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKNA--QISDKLITLFYGVVTPMLNPIIY 266
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
1-238 2.56e-32

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 118.31  E-value: 2.56e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15940   31 LHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLFACTEIFLLTIMAYDRYVAICNPLHYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15940  111 VMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKLACTDTYLIDILIVSNSGLISLVCFVAL 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASpEERKKAFSTCISHIGAVAVFYIPLIslsFIHRFGKEAPPyVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15940  191 LGSYIVILVSLRKRST-EGRRKALSTCASHLTVVTLFFGPCI---FIYTRPSTSFS-EDKVVSVFYTVVTPLLNPIIY 263
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
1-238 2.84e-32

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 118.49  E-value: 2.84e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15947   31 LHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWLGSTECVLLAVMAFDRYVAVCRPLHYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRG---TLILTPMVLllkRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDS 157
Cdd:cd15947  111 IMHPRLCVQLAALSWLSGlanSLLQTTLTL---QLPLCGHHTLDHFFCEVPALIKLACVDTTFNELELFVASVFFLLVPL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 158 VFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISL------SFIHRFGKeappyvhtLIANACLLIPP 231
Cdd:cd15947  188 SLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMylqppsSYSQDQGK--------FISLFYTVVTP 259

                 ....*..
gi 599412849 232 VMNPVVY 238
Cdd:cd15947  260 TLNPLIY 266
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
1-238 4.54e-32

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 117.97  E-value: 4.54e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15233   31 LHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHLLAGADCFLLTAMAYDRYLAICQPLTYSV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILT-DLKIAQIGVAIITRGTLILTPMVLLlKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVF 159
Cdd:cd15233  111 RMSwRVQTALVGISCACAFTNALTHTVAM-STLKFCGPNVINHFFCDLPPLFQLSCSSTHLNELLLFVFAFFMALAPCVL 189
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412849 160 IILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIsLSFIhRFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15233  190 IVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGV-FSYM-RLGSVYSSDKDKVIGILNTVLSPMLNPLIY 266
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
1-238 3.19e-31

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 115.98  E-value: 3.19e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15405   31 LHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFFVISECYVLTAMAYDRYVAICNPLLYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15405  111 TMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQLSCTSTYVNELVVFVVVGINIIVPSVTI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYiplISLSFIHRFGKEAPPYVHTLIANA-CLLIPPVMNPVVY 238
Cdd:cd15405  191 FISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFF---GSGAFMYLKPSSVGSVNQGKVSSVfYTNVVPMLNPLIY 266
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
1-238 6.07e-31

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 115.27  E-value: 6.07e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15432   31 LHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGLGSTECVLLAVMAFDRFAAICQPLHYSV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRG---TLILTPMVLLLKRlsyCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDS 157
Cdd:cd15432  111 IMHQRLCQQLAAGAWISGfanSLVQSTLTLKMPR---CGRRRVDHFFCEVPALLKLSCVDTTANEAELFVISVLLLLIPL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 158 VFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLsfihrFGKEAPPYVH---TLIANACLLIPPVMN 234
Cdd:cd15432  188 GLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISM-----YLQPPSNSSHdrgKMVALFYGIITPMLN 262

                 ....
gi 599412849 235 PVVY 238
Cdd:cd15432  263 PLIY 266
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
1-198 6.72e-31

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 115.27  E-value: 6.72e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15944   44 LHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKVISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYST 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVgLTALITTAGVDSVFI 160
Cdd:cd15944  124 LMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGSNIINHFFCDVPPLLALSCSDTHINEIL-LYVFCGFVEMSSLSI 202
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 599412849 161 IL-SYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15944  203 ILiSYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLFY 241
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
1-238 9.02e-31

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 114.22  E-value: 9.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15226   31 LHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFFGGSEMVLLIAMAFDRYVAICKPLHYLT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTR-----INSAVGLTALITTagv 155
Cdd:cd15226  111 IMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKLACTDTYvlelmVVANSGLISLVCF--- 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 156 dsVFIILSYILIIKTVLSiASPEERKKAFSTCISHIGAVAVFYIPLIslsFIHRFGKEAPPyVHTLIANACLLIPPVMNP 235
Cdd:cd15226  188 --LLLLISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCI---FIYVWPFSTFP-VDKFLAVFYTVITPLLNP 260

                 ...
gi 599412849 236 VVY 238
Cdd:cd15226  261 IIY 263
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
1-238 2.05e-29

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 111.03  E-value: 2.05e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15946   31 LHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLALGITECTLFSVMAYDRYVAICHPLRYKV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTD---LKIAQIGVAIITRGTLILTPMVLllkRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDS 157
Cdd:cd15946  111 IMSWglcILMVAGSWVCGVFSSLLHTFFTM---RLPYCGPNEINHYFCEVPAVLKLACADTSLNEMVDFVLGVIVLVVPL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 158 VFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFihRFGKEAPPYVHTLIANACLLIPPVMNPVV 237
Cdd:cd15946  188 SLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYM--RPGSNYSPERDKKISLFYNVFTALLNPVI 265

                 .
gi 599412849 238 Y 238
Cdd:cd15946  266 Y 266
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
1-238 1.88e-28

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 108.67  E-value: 1.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15942   31 LHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFLGCAECFLYTVMAYDRFLAICKPLHYST 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15942  111 IMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKLACADTAFNELVTFIDIGLVAMTCFLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPlisLSFIH-RFGKEAPpyVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15942  191 LMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVP---LTFIYlRPGSQDP--LDGVVAVFYTTVTPLLNPVIY 264
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
1-202 4.64e-28

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 107.30  E-value: 4.64e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15939   31 LGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHFFGGAEIFLLTVMAYDRYVAICKPLHYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYC-FHPdVMKLSCTDTRInsaVGLTaLITTAGVDSV- 158
Cdd:cd15939  111 IMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCdLFP-LLKLACTDTYV---IGLL-VVANSGLICLl 185
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 599412849 159 -FIIL--SYILIIKTvLSIASPEERKKAFSTCISHIGAVAVFYIPLI 202
Cdd:cd15939  186 sFLILliSYIVILYS-LRTHSSEGRRKALSTCGSHITVVVLFFVPCI 231
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
1-238 4.91e-28

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 107.47  E-value: 4.91e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15434   31 LHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLGGTECVLLAVMAYDRYAAVCQPLHYTV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTD---LKIAQIGVAIITRGTLILTPMVLLLKRlsyCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDS 157
Cdd:cd15434  111 VMHPrlcWKLVAMSWLIGFGNSLVLSPLTLSLPR---CGHHRVDHFFCEMPALIKLACVDTTAYEATIFALGVFILLFPL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 158 VFIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFI--HRFGKEAPPYVhTLIANaclLIPPVMNP 235
Cdd:cd15434  188 SLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQpkNSVSQDQGKFL-TLFYT---IVTPSLNP 263

                 ...
gi 599412849 236 VVY 238
Cdd:cd15434  264 LIY 266
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
1-238 5.09e-28

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 107.57  E-value: 5.09e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15428   31 LHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLSFGITECALLSVMSYDRYVAICLPLRYSL 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15428  111 IMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLKLASTDTHQAEMAMFIMCVFTLVLPVLLI 190
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLsFIHRFGKEAPPYVhTLIANACLLIPPVMNPVVY 238
Cdd:cd15428  191 LASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLST-YMRPKSSTSKEYD-KMISVFYIIVTPMLNPLIY 266
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
1-238 2.66e-27

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 105.63  E-value: 2.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15418   32 LHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFFSAGLAYSECFLLAAMAYDRYVAICNPLLYSS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15418  112 AMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPPLVKLACDDTRVYELILYFILGFNVIAPTALI 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYiplISLSFIH-RFGKEAPPYVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15418  192 LASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYY---GSILFIYsRPSSSHTPDRDKVVALFYTVVNPLLNPLIY 267
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
1-238 9.14e-27

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 103.95  E-value: 9.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15936   31 LHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFTGGAEVFLLSVMAYDRYIAIHKPLHYLT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINS--AVGLTALITTagvdSV 158
Cdd:cd15936  111 IMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKLACTDTFLLEllMVSNSGLVTL----LI 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 159 FIIL--SYIlIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsFIHrfgkeAPPY----VHTLIANACLLIPPV 232
Cdd:cd15936  187 FFILliSYT-VILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCI---YIY-----ARPFqtfpMDKAVSVLYTVITPM 257

                 ....*.
gi 599412849 233 MNPVVY 238
Cdd:cd15936  258 LNPMIY 263
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
1-198 1.44e-25

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 100.85  E-value: 1.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15913   31 LHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSLGTTECFFLSVMAFDRYLAICRPLHYPT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAV--GLTALITTAGVdsV 158
Cdd:cd15913  111 IMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLALSCVPAPGTELIcyTLSSLIIFGTF--L 188
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 599412849 159 FIILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY 198
Cdd:cd15913  189 FILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFY 228
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
1-238 4.10e-25

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 99.45  E-value: 4.10e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15935   32 LQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFLHFLGGSEMLLLTLMAYDRYVAICHPLRYLA 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVgltaLITTAGVDSV-- 158
Cdd:cd15935  112 VMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQVIKLACMDTYVVEVL----MVANSGLLSLvc 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 159 FIIL--SYILIIKTVLSIASpEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEappyVHTLIANACLLIPPVMNPV 236
Cdd:cd15935  188 FLVLlvSYGIILTTLRGRFR-EGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSSSS----VDKVASVFYTLITPALNPL 262

                 ..
gi 599412849 237 VY 238
Cdd:cd15935  263 IY 264
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
1-238 2.38e-23

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 94.94  E-value: 2.38e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15938   31 LSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFVGAAEMFLLTVMAYDRYVAICKPLHYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINS--AVGLTALITTagVDSV 158
Cdd:cd15938  111 IMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKLACTDTCVTEllMVSNSGLIST--VCFV 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 159 FIILSYILIIktvLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsFIHRFGKEAPPyVHTLIANACLLIPPVMNPVVY 238
Cdd:cd15938  189 VLVTSYTTIL---VTIRSTEGRRKALSTCASHLMVVTLFFGPCI---FIYARPFSTFP-VDKHVSVLYNVITPMLNPLIY 261
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
1-238 6.42e-23

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 93.70  E-value: 6.42e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15433   31 LHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLALGSAECVLLAVMAFDRYAAVCRPLHYAA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFI 160
Cdd:cd15433  111 LMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLKLACGDDETTEVQMFVARVVILLLPAALI 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 161 ILSYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFY--IPLISLSFIHRFGKEAPPYVHTLIAnaclLIPPVMNPVVY 238
Cdd:cd15433  191 LGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYgsAIYTYLQPIHRYSQAHGKFVSLFYT----VMTPALNPLIY 266
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
4-238 1.33e-21

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 90.29  E-value: 1.33e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   4 PMFIFLSMLSTTDLGLSISTLVTML-GIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYASIL 82
Cdd:cd15941   35 PMYHFLGHLSFLDACLSSVTVPKVLaGLLTLSGRTISFEGCVVQLYAFHFLASTECFLYTVMAYDRYLAICHPLHYPTAM 114
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  83 TDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVGLTALITTAGVDSVFIIL 162
Cdd:cd15941  115 NRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPVLKLACADTTINELVILANIGIVAAGCFLLIVI 194
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 599412849 163 SYILIIKTVLSIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTLIAnaclLIPPVMNPVVY 238
Cdd:cd15941  195 SYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSSSQAGAGAPAVFYT----IVTPMLNPFIY 266
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
1-238 4.06e-18

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 80.55  E-value: 4.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYAS 80
Cdd:cd15937   31 LGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLHFLGAAEMFLLVAMAYDRYVAICKPLHYTT 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  81 ILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHSHVLHHSYCFHPDVMKLSCTDTRINSAVgltaLITTAGVDSVF- 159
Cdd:cd15937  111 VVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVIKLACTNTYTVELL----MFSNSGLVILLc 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 160 ---IILSYILIIkTVLSIASPEERKKAFSTCISHIGAVAVFYIPLIslsFIHRFGKEAPPyVHTLIANACLLIPPVMNPV 236
Cdd:cd15937  187 fllLLISYAFLL-AKLRTHSSKGKSKAASTCITHIIIVFVMFGPAI---YIYARPFRSFP-MDKVVAVFHTVIFPLLNPM 261

                 ..
gi 599412849 237 VY 238
Cdd:cd15937  262 IY 263
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-238 2.09e-14

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 70.40  E-value: 2.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849    1 LHQPMFIFLSMLSTTDLGLSISTL-VTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAFDRFVAISNPLRYA 79
Cdd:pfam00001  15 LRTPTNIFLLNLAVADLLFSLLTLpFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYK 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   80 SILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYCHShvlHHSYCFHPDVMKLSCtdtriNSAVGLTALITTAGVDSVF 159
Cdd:pfam00001  95 RRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEG---NVTVCFIDFPEDLSK-----PVSYTLLISVLGFLLPLLV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  160 IILSYILIIKTVLSIASPEER-------KKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPY-VHTLIANACLLIP- 230
Cdd:pfam00001 167 ILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSrLLDKALSVTLWLAy 246
                         250
                  ....*....|
gi 599412849  231 --PVMNPVVY 238
Cdd:pfam00001 247 vnSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
1-238 7.98e-08

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 51.52  E-value: 7.98e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTReiSSNASMSQMFFIQLFTVMESSV--LLAMAFDRFVAISNPLRY 78
Cdd:cd00637   29 LRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRW--WFGDALCKLLGFLQSVSLLASIltLTAISVDRYLAIVHPLRY 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849  79 ASILTDLKIAQIGVAIITRGTLILTPMVLLLKRLSYchshvlhhsycFHPDVMKLSCTDTRINSAVGLTALITTAGVDSV 158
Cdd:cd00637  107 RRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDY-----------GGYCCCCLCWPDLTLSKAYTIFLFVLLFLLPLL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849 159 FIILSYILIIKTVL--------------SIASPEERKKAFSTCISHIGAVAVFYIPLISLSFIHRFGKEAPPYVHTL--I 222
Cdd:cd00637  176 VIIVCYVRIFRKLRrhrrrirssssnssRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRILyfL 255
                        250
                 ....*....|....*.
gi 599412849 223 ANACLLIPPVMNPVVY 238
Cdd:cd00637  256 ALLLAYLNSAINPIIY 271
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
1-88 1.73e-05

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 44.59  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFntreiSSNASMSQMFFIQLFTVME--SSV--LLAMAFDRFVAISNPL 76
Cdd:cd14972   29 LHKPMYILIANLAAADLLAGIAFVFTFLSVLLV-----SLTPSPATWLLRKGSLVLSllASAysLLAIAVDRYISIVHGL 103
                         90
                 ....*....|..
gi 599412849  77 RYASILTDLKIA 88
Cdd:cd14972  104 TYVNNVTNKRVK 115
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
1-103 3.06e-04

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 40.93  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 599412849   1 LHQPMFIFLSMLSTTDLGLSISTLVTMLGIFWFNTREISSNASMSQMFFIQLFTVMESSVLLAMAF------DRFVAISN 74
Cdd:cd15351   31 LHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQHMDNVIDTMICSSVVSSLSFlgaiavDRYITIFY 110
                         90       100       110
                 ....*....|....*....|....*....|...
gi 599412849  75 PLRYASILTDLK----IAQIGVAIITRGTLILT 103
Cdd:cd15351  111 ALRYHSIMTLQRavnaIAGIWLASTVSSTLFIV 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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