NCBI Conserved Domain Search

Conserved domains on [gi|597894931|gb|EYC43056|]

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hypothetical protein Y032_0505g2662 [Ancylostoma ceylanicum]

Protein Classification

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PTPc_DSPc

smart00012

Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine ...

1-96

1.98e-30

Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine phosphatases. Homologues detected by this profile and not by those of "PTPc" or "DSPc" are predicted to be protein phosphatases with a similar fold to DSPs and PTPs, yet with unpredicted specificities.

Pssm-ID: 214469 [Multi-domain] Cd Length: 105 Bit Score: 104.75 E-value: 1.98e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931     1 MHYHWQDWPDRGVPDADLAPIVLLARLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLIEL 74
Cdd:smart00012   3 KHYHYTGWPDHGVPESPDSILELLRAVKKNlnqsesSGPVVVHCSAGVGRTGTFVAIDILLQQLEAEAGEVDIFDTVKEL 82

                           90       100
                   ....*....|....*....|..
gi 597894931    75 RKQRNNSIQTEHQYLYIHQVLL 96
Cdd:smart00012  83 RSQRPGMVQTEEQYLFLYRALL 104

Name

Accession

Description

Interval

E-value

PTPc_DSPc

smart00012

Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine ...

1-96

1.98e-30

Pssm-ID: 214469 [Multi-domain] Cd Length: 105 Bit Score: 104.75 E-value: 1.98e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931     1 MHYHWQDWPDRGVPDADLAPIVLLARLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLIEL 74
Cdd:smart00012   3 KHYHYTGWPDHGVPESPDSILELLRAVKKNlnqsesSGPVVVHCSAGVGRTGTFVAIDILLQQLEAEAGEVDIFDTVKEL 82

                           90       100
                   ....*....|....*....|..
gi 597894931    75 RKQRNNSIQTEHQYLYIHQVLL 96
Cdd:smart00012  83 RSQRPGMVQTEEQYLFLYRALL 104

Y_phosphatase

pfam00102

Protein-tyrosine phosphatase;

1-96

2.99e-30

Protein-tyrosine phosphatase;

Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 108.10 E-value: 2.99e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931    1 MHYHWQDWPDRGVPDADLAPIVLLARLKE-----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPaPLLEISTYLIELR 75
Cdd:pfam00102 134 KHFHYTGWPDHGVPESPNSLLDLLRKVRKssldgRSGPIVVHCSAGIGRTGTFIAIDIALQQLEAE-GEVDIFQIVKELR 212

                          90       100
                  ....*....|....*....|.
gi 597894931   76 KQRNNSIQTEHQYLYIHQVLL 96
Cdd:pfam00102 213 SQRPGMVQTLEQYIFLYDAIL 233

PTPc

cd00047

catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1. ...

1-93

2.60e-24

catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (pTyr) residues, instead of pSer or pThr. This family has a distinctive active site signature motif, HCSAGxGRxG, and are characterized as either transmembrane, receptor-like or non-transmembrane (soluble) PTPs. Receptor-like PTP domains tend to occur in two copies in the cytoplasmic region of the transmembrane proteins, only one copy may be active.

Pssm-ID: 350343 [Multi-domain] Cd Length: 200 Bit Score: 91.96 E-value: 2.60e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDaDLAPIVLLAR-----LKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLpAPLLEISTYLIELR 75
Cdd:cd00047  105 THLHYTGWPDHGVPS-SPEDLLALVRrvrkeARKPNGPIVVHCSAGVGRTGTFIAIDILLERLEA-EGEVDVFEIVKALR 182

                         90
                 ....*....|....*...
gi 597894931  76 KQRNNSIQTEHQYLYIHQ 93
Cdd:cd00047  183 KQRPGMVQTLEQYEFIYE 200

COG5599

Protein tyrosine phosphatase [Signal transduction mechanisms];

2-88

2.81e-13

Protein tyrosine phosphatase [Signal transduction mechanisms];

Pssm-ID: 444335 [Multi-domain] Cd Length: 282 Bit Score: 64.34 E-value: 2.81e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAD-LAPIVLLARLKENTA-----PIIVHCSAGIGRTGSIVLIqHAME--LLHLPAPLLEISTYLIE 73
Cdd:COG5599  171 VLHVKNWPDHGAISAEaLKNLADLIDKKEKIKdpdklLPVVHCRAGVGRTGTLIAC-LALSksINALVQITLSVEEIVID 249

                         90
                 ....*....|....*.
gi 597894931  74 LRKQRNNSI-QTEHQY 88
Cdd:COG5599  250 MRTSRNGGMvQTSEQL 265

PHA02742

protein tyrosine phosphatase; Provisional

2-100

3.10e-13

protein tyrosine phosphatase; Provisional

Pssm-ID: 165109 [Multi-domain] Cd Length: 303 Bit Score: 64.25 E-value: 3.10e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD--ADLAPIVLLARLKENTA-------------PIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLE 66
Cdd:PHA02742 185 HFAYEDWPHGGLPRdpNKFLDFVLAVREADLKAdvdikgenivkepPILVHCSAGLDRAGAFCAIDICISKYNERA-IIP 263

                         90       100       110
                 ....*....|....*....|....*....|....
gi 597894931  67 ISTYLIELRKQRNNSIQTEHQYLYIHQVLLLYLK 100
Cdd:PHA02742 264 LLSIVRDLRKQRHNCLSLPQQYIFCYFIVLIFAK 297

Name

Accession

Description

Interval

E-value

PTPc_DSPc

smart00012

Protein tyrosine phosphatase, catalytic domain, undefined specificity; Protein tyrosine ...

1-96

1.98e-30

Pssm-ID: 214469 [Multi-domain] Cd Length: 105 Bit Score: 104.75 E-value: 1.98e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931     1 MHYHWQDWPDRGVPDADLAPIVLLARLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLIEL 74
Cdd:smart00012   3 KHYHYTGWPDHGVPESPDSILELLRAVKKNlnqsesSGPVVVHCSAGVGRTGTFVAIDILLQQLEAEAGEVDIFDTVKEL 82

                           90       100
                   ....*....|....*....|..
gi 597894931    75 RKQRNNSIQTEHQYLYIHQVLL 96
Cdd:smart00012  83 RSQRPGMVQTEEQYLFLYRALL 104

PTPc_motif

smart00404

Protein tyrosine phosphatase, catalytic domain motif;

1-96

1.98e-30

Protein tyrosine phosphatase, catalytic domain motif;

Pssm-ID: 214649 [Multi-domain] Cd Length: 105 Bit Score: 104.75 E-value: 1.98e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931     1 MHYHWQDWPDRGVPDADLAPIVLLARLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLIEL 74
Cdd:smart00404   3 KHYHYTGWPDHGVPESPDSILELLRAVKKNlnqsesSGPVVVHCSAGVGRTGTFVAIDILLQQLEAEAGEVDIFDTVKEL 82

                           90       100
                   ....*....|....*....|..
gi 597894931    75 RKQRNNSIQTEHQYLYIHQVLL 96
Cdd:smart00404  83 RSQRPGMVQTEEQYLFLYRALL 104

Y_phosphatase

pfam00102

Protein-tyrosine phosphatase;

1-96

2.99e-30

Protein-tyrosine phosphatase;

Pssm-ID: 459674 [Multi-domain] Cd Length: 234 Bit Score: 108.10 E-value: 2.99e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931    1 MHYHWQDWPDRGVPDADLAPIVLLARLKE-----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPaPLLEISTYLIELR 75
Cdd:pfam00102 134 KHFHYTGWPDHGVPESPNSLLDLLRKVRKssldgRSGPIVVHCSAGIGRTGTFIAIDIALQQLEAE-GEVDIFQIVKELR 212

                          90       100
                  ....*....|....*....|.
gi 597894931   76 KQRNNSIQTEHQYLYIHQVLL 96
Cdd:pfam00102 213 SQRPGMVQTLEQYIFLYDAIL 233

PTPc

smart00194

Protein tyrosine phosphatase, catalytic domain;

1-96

4.48e-30

Protein tyrosine phosphatase, catalytic domain;

Pssm-ID: 214550 [Multi-domain] Cd Length: 259 Bit Score: 108.52 E-value: 4.48e-30

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931     1 MHYHWQDWPDRGVPDADLAPIVLLARLKE----NTAPIIVHCSAGIGRTGSIVLIQHAMELL--HLPAPLLEIstyLIEL 74
Cdd:smart00194 160 THYHYTNWPDHGVPESPESILDLIRAVRKsqstSTGPIVVHCSAGVGRTGTFIAIDILLQQLeaGKEVDIFEI---VKEL 236

                           90       100
                   ....*....|....*....|..
gi 597894931    75 RKQRNNSIQTEHQYLYIHQVLL 96
Cdd:smart00194 237 RSQRPGMVQTEEQYIFLYRAIL 258

PTPc

cd00047

catalytic domain of protein tyrosine phosphatases; Protein tyrosine phosphatases (PTP, EC 3.1. ...

1-93

2.60e-24

Pssm-ID: 350343 [Multi-domain] Cd Length: 200 Bit Score: 91.96 E-value: 2.60e-24

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDaDLAPIVLLAR-----LKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLpAPLLEISTYLIELR 75
Cdd:cd00047  105 THLHYTGWPDHGVPS-SPEDLLALVRrvrkeARKPNGPIVVHCSAGVGRTGTFIAIDILLERLEA-EGEVDVFEIVKALR 182

                         90
                 ....*....|....*...
gi 597894931  76 KQRNNSIQTEHQYLYIHQ 93
Cdd:cd00047  183 KQRPGMVQTLEQYEFIYE 200

R5-PTPc-1

cd14549

catalytic domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The R5 ...

1-92

1.93e-22

catalytic domain of R5 subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The R5 subfamily of receptor-type phosphotyrosine phosphatases (RPTP) is composed of receptor-type tyrosine-protein phosphatase Z (PTPRZ) and G (PTPRG). They belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. They are type 1 integral membrane proteins consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350397 [Multi-domain] Cd Length: 204 Bit Score: 87.41 E-value: 1.93e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDaDLAPIVLLARlKENTA------PIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIEL 74
Cdd:cd14549  109 YQYHYTQWPDHGVPD-YTLPVLSFVR-KSSAAnppgagPIVVHCSAGVGRTGTYIVIDSMLQQIQ-DKGTVNVFGFLKHI 185

                         90
                 ....*....|....*...
gi 597894931  75 RKQRNNSIQTEHQYLYIH 92
Cdd:cd14549  186 RTQRNYLVQTEEQYIFIH 203

R-PTPc-LAR-1

cd14553

catalytic domain of LAR family receptor-type tyrosine-protein phosphatases, repeat 1; The LAR ...

2-96

2.59e-21

catalytic domain of LAR family receptor-type tyrosine-protein phosphatases, repeat 1; The LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs) include three vertebrate members: LAR (or PTPRF), R-PTP-delta (or PTPRD), and R-PTP-sigma (or PTPRS). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules; they bind to distinct synaptic membrane proteins and are physiologically responsible for mediating presynaptic development by shaping various synaptic adhesion pathways. They play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. LAR-RPTPs contain an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350401 [Multi-domain] Cd Length: 238 Bit Score: 85.14 E-value: 2.59e-21

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE----NTAPIIVHCSAGIGRTGSIVLIQHAMELLhLPAPLLEISTYLIELRKQ 77
Cdd:cd14553  136 QFQFTAWPDHGVPEHPTPFLAFLRRVKAcnppDAGPIVVHCSAGVGRTGCFIVIDSMLERI-KHEKTVDIYGHVTCLRAQ 214

                         90
                 ....*....|....*....
gi 597894931  78 RNNSIQTEHQYLYIHQVLL 96
Cdd:cd14553  215 RNYMVQTEDQYIFIHDALL 233

R-PTPc-G-1

cd17667

catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1; Receptor-type ...

1-96

1.23e-20

catalytic domain of receptor-type tyrosine-protein phosphatase G, repeat 1; Receptor-type tyrosine-protein phosphatase G (PTPRG), also called protein-tyrosine phosphatase gamma (R-PTP-gamma), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRG is an important tumor suppressor gene in multiple human cancers such as lung, ovarian, and breast cancers. It is widely expressed in many tissues, including the central nervous system, where it plays a role during neuroinflammation processes. It can dephosphorylate platelet-derived growth factor receptor beta (PDGFRB) and may play a role in PDGFRB-related infantile myofibromatosis. PTPRG has four splicing isoforms: three transmembrane isoforms, PTPRG-A, B, and C, and one secretory isoform, PTPRG-S, which are expressed in many tissues including the brain. PTPRG is a type 1 integral membrane protein consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350505 [Multi-domain] Cd Length: 274 Bit Score: 83.93 E-value: 1.23e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDADLaPIVLLARLKE-----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIELR 75
Cdd:cd17667  172 IQYHYTQWPDMGVPEYAL-PVLTFVRRSSaartpEMGPVLVHCSAGVGRTGTYIVIDSMLQQIK-DKSTVNVLGFLKHIR 249

                         90       100
                 ....*....|....*....|.
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd17667  250 TQRNYLVQTEEQYIFIHDALL 270

R-PTPc-Z-1

cd17668

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 1; Receptor-type ...

1-96

1.62e-20

catalytic domain of receptor-type tyrosine-protein phosphatase Z, repeat 1; Receptor-type tyrosine-protein phosphatase Z (PTPRZ), also called receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Three isoforms are generated by alternative splicing from a single PTPRZ gene: two transmembrane isoforms, PTPRZ-A and PTPRZ-B, and one secretory isoform, PTPRZ-S (also known as phosphacan); all are preferentially expressed in the central nervous system (CNS) as chondroitin sulfate (CS) proteoglycans. PTPRZ isoforms play important roles in maintaining oligodendrocyte precursor cells in an undifferentiated state. PTPRZ is a type 1 integral membrane protein consisting of an extracellular region with a carbonic anhydrase-like (CAH) and a fibronectin type III (FN3) domains, and an intracellular region with a catalytic PTP domain (repeat 1) proximal to the membrane, and a catalytically inactive PTP-fold domain (repeat 2) distal to the membrane. This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350506 [Multi-domain] Cd Length: 209 Bit Score: 82.33 E-value: 1.62e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDADLAPIVLL-----ARLKENtAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEISTYLIELR 75
Cdd:cd17668  111 TQYHYTQWPDMGVPEYTLPVLTFVrkasyAKRHAV-GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT-VNIFGFLKHIR 188

                         90       100
                 ....*....|....*....|.
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd17668  189 SQRNYLVQTEEQYVFIHDALV 209

PTPc-N20_13

cd14538

catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13; ...

1-96

2.34e-20

catalytic domain of tyrosine-protein phosphatase non-receptor type 20 and type 13; Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) and type 13 (PTPN13, also known as PTPL1) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization. Human PTPN13 is an important regulator of tumor aggressiveness.

Pssm-ID: 350386 [Multi-domain] Cd Length: 207 Bit Score: 82.04 E-value: 2.34e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDA--DLAPIVLLARLKENTAPIIVHCSAGIGRTGSIVLIQHAMELLH--LPAPLLEISTYlieLRK 76
Cdd:cd14538  108 THLNFTTWPDHGTPQSadPLLRFIRYMRRIHNSGPIVVHCSAGIGRTGVLITIDVALGLIErdLPFDIQDIVKD---LRE 184

                         90       100
                 ....*....|....*....|
gi 597894931  77 QRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14538  185 QRQGMIQTKDQYIFCYKACL 204

R-PTPc-E-1

cd14620

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1; Receptor-type ...

1-96

4.02e-20

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 1; Receptor-type tyrosine-protein phosphatase E (PTPRE), also known as receptor-type tyrosine-protein phosphatase epsilon (R-PTP-epsilon), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. The PTPRE gene contains two distinct promoters that generate the two major isoforms: transmembrane (receptor type RPTPe or PTPeM) and cytoplasmic (cyt-PTPe or PTPeC). Receptor type RPTPe plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells, and may also play a role in osteoclast formation and function. It also negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis. cyt-PTPe acts as a negative regulator of insulin receptor signaling in skeletal muscle. It regulates insulin-induced phosphorylation of proteins downstream of the insulin receptor. Receptor type RPTPe contains a small extracellular region, a single transmembrane segment, and an intracellular region two tandem catalytic PTP domains. This model represents the first PTP domain (repeat 1).

Pssm-ID: 350468 [Multi-domain] Cd Length: 229 Bit Score: 81.91 E-value: 4.02e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPdadLAPIVLLARLKE-------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEISTYLIE 73
Cdd:cd14620  130 TQLHFTSWPDFGVP---FTPIGMLKFLKKvksvnpvHAGPIVVHCSAGVGRTGTFIVIDAMIDMMHAEQK-VDVFEFVSR 205

                         90       100
                 ....*....|....*....|...
gi 597894931  74 LRKQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14620  206 IRNQRPQMVQTDMQYSFIYQALL 228

PTPc-N18

cd14603

catalytic domain of tyrosine-protein phosphatase non-receptor type 18; Tyrosine-protein ...

2-93

6.98e-20

catalytic domain of tyrosine-protein phosphatase non-receptor type 18; Tyrosine-protein phosphatase non-receptor type 18 (PTPN18), also called brain-derived phosphatase, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination states. The N-terminal catalytic PTP domain of PTPN18 blocks lysosomal routing and delays the degradation of HER2 by dephosphorylation, and its C-terminal PEST domain promotes K48-linked HER2 ubiquitination and its destruction via the proteasome pathway.

Pssm-ID: 350451 [Multi-domain] Cd Length: 266 Bit Score: 81.80 E-value: 6.98e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAD---LAPIVLLARLK-ENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLP--APLLEISTYLIELR 75
Cdd:cd14603  163 HFQYMAWPDHGIPDSPdcmLAMIELARRLQgSGPEPLCVHCSAGCGRTGVICTVDYVRQLLLTQriPPDFSIFDVVLEMR 242

                         90
                 ....*....|....*...
gi 597894931  76 KQRNNSIQTEHQYLYIHQ 93
Cdd:cd14603  243 KQRPAAVQTEEQYEFLYH 260

R3-PTPc

cd14548

catalytic domain of R3 subfamily receptor-type tyrosine-protein phosphatases and similar ...

1-93

9.81e-20

catalytic domain of R3 subfamily receptor-type tyrosine-protein phosphatases and similar proteins; R3 subfamily receptor-type phosphotyrosine phosphatases (RPTP) are characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. Vertebrate members include receptor-type tyrosine-protein phosphatase-like O (PTPRO), J (PTPRJ), Q (PTPRQ), B (PTPRB), V (PTPRV) and H (PTPRH). They belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Most members are PTPs, except for PTPRQ, which dephosphorylates phosphatidylinositide substrates. PTPRV is characterized only in rodents; its function has been lost in humans. Both vertebrate and invertebrate R3 subfamily RPTPs are involved in the control of a variety of cellular processes, including cell growth, differentiation, mitotic cycle and oncogenic transformation.

Pssm-ID: 350396 [Multi-domain] Cd Length: 222 Bit Score: 80.48 E-value: 9.81e-20

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDAdlaPIVLLA-------RLKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIE 73
Cdd:cd14548  127 RQFHFTAWPDHGVPEA---PDSLLRfvrlvrdYIKQEKGPTIVHCSAGVGRTGTFIALDRLLQQIE-SEDYVDIFGIVYD 202

                         90       100
                 ....*....|....*....|
gi 597894931  74 LRKQRNNSIQTEHQYLYIHQ 93
Cdd:cd14548  203 LRKHRPLMVQTEAQYIFLHQ 222

R-PTPc-O

cd14614

catalytic domain of receptor-type tyrosine-protein phosphatase O; Receptor-type ...

1-97

1.85e-19

catalytic domain of receptor-type tyrosine-protein phosphatase O; Receptor-type tyrosine-protein phosphatase O (PTPRO or R-PTP-O), also known as glomerular epithelial protein 1 or protein tyrosine phosphatase U2 (PTP-U2), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRO is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is essential for sustaining the structure and function of foot processes by regulating tyrosine phosphorylation of podocyte proteins. It has been identified as a synaptic cell adhesion molecule (CAM) that serves as a potent initiator of synapse formation. It is also a tumor suppressor in several types of cancer, such as hepatocellular carcinoma, lung cancer, and breast cancer.

Pssm-ID: 350462 [Multi-domain] Cd Length: 245 Bit Score: 80.32 E-value: 1.85e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDADLAPIVL----LARLKENTA--PIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIEL 74
Cdd:cd14614  143 MHFNYTAWPDHGVPTANAAESILqfvqMVRQQAVKSkgPMIIHCSAGVGRTGTFIALDRLLQHIR-DHEFVDILGLVSEM 221

                         90       100
                 ....*....|....*....|...
gi 597894931  75 RKQRNNSIQTEHQYLYIHQVLLL 97
Cdd:cd14614  222 RSYRMSMVQTEEQYIFIHQCVQL 244

PTP_fungal

cd18533

fungal protein tyrosine phosphatases; This subfamily contains Saccharomyces cerevisiae ...

2-93

1.94e-19

fungal protein tyrosine phosphatases; This subfamily contains Saccharomyces cerevisiae protein-tyrosine phosphatases 1 (PTP1) and 2 (PTP2), Schizosaccharomyces pombe PTP1, PTP2, and PTP3, and similar fungal proteins. PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. PTP2, together with PTP3, is the major phosphatase that dephosphorylates and inactivates the MAP kinase HOG1 and also modulates its subcellular localization.

Pssm-ID: 350509 [Multi-domain] Cd Length: 212 Bit Score: 79.60 E-value: 1.94e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDaDLAPIVLLARLK-------ENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLE-------- 66
Cdd:cd18533  107 HIQYKSWPDFGVPD-SPEDLLTLIKLKrelndsaSLDPPIIVHCSAGVGRTGTFIALDSLLDELKRGLSDSQdledsedp 185

                         90       100
                 ....*....|....*....|....*..
gi 597894931  67 ISTYLIELRKQRNNSIQTEHQYLYIHQ 93
Cdd:cd18533  186 VYEIVNQLRKQRMSMVQTLRQYIFLYD 212

R-PTPc-F-1

cd14626

catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1; Receptor-type ...

2-96

2.14e-19

catalytic domain of receptor-type tyrosine-protein phosphatase F, repeat 1; Receptor-type tyrosine-protein phosphatase F (PTPRF), also known as leukocyte common antigen related (LAR), is the prototypical member of the LAR family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRF/LAR plays a role for LAR in cadherin complexes where it associates with and dephosphorylates beta-catenin, a pathway which may be critical for cadherin complex stability and cell-cell association. It also regulates focal adhesions through cyclin-dependent kinase-1 and is involved in axon guidance in the developing nervous system. It also functions in regulating insulin signaling. PTPRF contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350474 [Multi-domain] Cd Length: 276 Bit Score: 80.85 E-value: 2.14e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEISTYLIELRKQ 77
Cdd:cd14626  174 QFQFMAWPDHGVPEYPTPILAFLRRVKAcnppDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKT-VDIYGHVTCMRSQ 252

                         90
                 ....*....|....*....
gi 597894931  78 RNNSIQTEHQYLYIHQVLL 96
Cdd:cd14626  253 RNYMVQTEDQYIFIHEALL 271

PTPc-N22_18_12

cd14542

catalytic domain of tyrosine-protein phosphatase non-receptor type 22, type 18 and type 12; ...

3-93

7.38e-19

catalytic domain of tyrosine-protein phosphatase non-receptor type 22, type 18 and type 12; Tyrosine-protein phosphatase non-receptor type 22 (PTPN22), type 18 (PTPN18) and type 12 (PTPN12) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN22 is expressed in hematopoietic cells and it functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signaling through the direct dephosphorylation of Src family kinases (Lck and Fyn), ITAMs of the TCRz/CD3 complex, and other signaling molecules. TPN18 regulates HER2-mediated cellular functions through defining both its phosphorylation and ubiquitination states. PTPN12 is characterized as a tumor suppressor and a pivotal regulator of EGFR/HER2 signaling.

Pssm-ID: 350390 [Multi-domain] Cd Length: 202 Bit Score: 77.85 E-value: 7.38e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQDWPDRGVPDAdLAPIVLLARL-----KENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLI--ELR 75
Cdd:cd14542  106 FHYTAWPDHGVPSS-VDPILDLVRLvrdyqGSEDVPICVHCSAGCGRTGTICAIDYVWNLLKTGKIPEEFSLFDLvrEMR 184

                         90
                 ....*....|....*...
gi 597894931  76 KQRNNSIQTEHQYLYIHQ 93
Cdd:cd14542  185 KQRPAMVQTKEQYELVYR 202

PTPc-N11_6

cd14544

catalytic domain of tyrosine-protein phosphatase non-receptor type 11 and type 6; ...

2-100

9.00e-19

catalytic domain of tyrosine-protein phosphatase non-receptor type 11 and type 6; Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) and type 6 (PTPN6) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN11 and PTPN6, are also called SH2 domain-containing tyrosine phosphatase 2 (SHP2) and 1 (SHP1), respectively. They contain two tandem SH2 domains: a catalytic PTP domain, and a C-terminal tail with regulatory properties. Although structurally similar, they have different localization and different roles in signal transduction. PTPN11/SHP2 is expressed ubiquitously and plays a positive role in cell signaling, leading to cell activation, while PTPN6/SHP1 expression is restricted mainly to hematopoietic and epithelial cells and functions as a negative regulator of signaling events.

Pssm-ID: 350392 [Multi-domain] Cd Length: 251 Bit Score: 78.66 E-value: 9.00e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPdadLAPIVLLARLKE---------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTY-L 71
Cdd:cd14544  144 HYQYLSWPDHGVP---SDPGGVLNFLEDvnqrqeslpHAGPIVVHCSAGIGRTGTFIVIDMLLDQIKRKGLDCDIDIQkT 220

                         90       100       110
                 ....*....|....*....|....*....|
gi 597894931  72 IEL-RKQRNNSIQTEHQYLYIHQVLLLYLK 100
Cdd:cd14544  221 IQMvRSQRSGMVQTEAQYKFIYVAVAQYIE 250

R-PTPc-A-E-1

cd14551

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 1; ...

2-93

1.88e-18

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 1; Receptor-type tyrosine-protein phosphatase A (PTPRA) and E (PTPRE) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA and PTPRE share several functions including regulation of Src family kinases and voltage-gated potassium (Kv) channels. They both contain a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the first catalytic PTP domain (repeat 1).

Pssm-ID: 350399 [Multi-domain] Cd Length: 202 Bit Score: 76.87 E-value: 1.88e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPdadLAPIVLLARLKENTA-------PIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEISTYLIEL 74
Cdd:cd14551  108 QFHFTSWPDFGVP---FTPIGMLKFLKKVKSanppragPIVVHCSAGVGRTGTFIVIDAMLDMMHAEGK-VDVFGFVSRI 183

                         90
                 ....*....|....*....
gi 597894931  75 RKQRNNSIQTEHQYLYIHQ 93
Cdd:cd14551  184 RQQRSQMVQTDMQYVFIYQ 202

R-PTPc-S-1

cd14625

catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1; Receptor-type ...

2-96

2.38e-18

catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1; Receptor-type tyrosine-protein phosphatase S (PTPRS), also known as receptor-type tyrosine-protein phosphatase sigma (R-PTP-sigma), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRS is a receptor for glycosaminoglycans, including heparan sulfate proteoglycan and neural chondroitin sulfate proteoglycans (CSPGs), which present a barrier to axon regeneration. It also plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. PTPRS contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350473 [Multi-domain] Cd Length: 282 Bit Score: 78.21 E-value: 2.38e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIELRKQ 77
Cdd:cd14625  180 QFQFTAWPDHGVPEYPTPFLAFLRRVKTcnppDAGPIVVHCSAGVGRTGCFIVIDAMLERIK-HEKTVDIYGHVTLMRSQ 258

                         90
                 ....*....|....*....
gi 597894931  78 RNNSIQTEHQYLYIHQVLL 96
Cdd:cd14625  259 RNYMVQTEDQYSFIHDALL 277

PTPc-N14

cd14599

catalytic domain of tyrosine-protein phosphatase non-receptor type 14; Tyrosine-protein ...

2-100

7.26e-18

catalytic domain of tyrosine-protein phosphatase non-receptor type 14; Tyrosine-protein phosphatase non-receptor type 14 (PTPN14), also called protein-tyrosine phosphatase pez, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN14 is a potential tumor suppressor and plays a regulatory role in the Hippo and Wnt/beta-catenin signaling pathways. It contains an N-terminal FERM domain and a C-terminal catalytic PTP domain, separated by a long intervening sequence.

Pssm-ID: 350447 [Multi-domain] Cd Length: 287 Bit Score: 76.96 E-value: 7.26e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD------ADLAPI--------VLLARLKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEI 67
Cdd:cd14599  176 HLQYTDWPDHGCPEevqgflSYLEEIqsvrrhtnSMLDSTKNCNPPIVVHCSAGVGRTGVVILTELMIGCLEHNEK-VEV 254

                         90       100       110
                 ....*....|....*....|....*....|...
gi 597894931  68 STYLIELRKQRNNSIQTEHQYLYIHQVLLLYLK 100
Cdd:cd14599  255 PVMLRHLREQRMFMIQTIAQYKFVYQVLIQFLK 287

PTPc_plant_PTP1

cd17658

protein tyrosine phosphatase 1 from Arabidopsis thaliana and similar plant PTPs; Arabidopsis ...

1-92

7.64e-18

protein tyrosine phosphatase 1 from Arabidopsis thaliana and similar plant PTPs; Arabidopsis thaliana protein tyrosine phosphatase 1 (AtPTP1) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. AtPTP1 dephosphorylates and inhibits MAP kinase 6 (MPK6) in non-oxidative stress conditions. Together with MAP kinase phosphatase 1 (MKP1) it expresses salicylic acid (SA) and camalexin biosynthesis, and therefore, modulating defense response.

Pssm-ID: 350496 [Multi-domain] Cd Length: 206 Bit Score: 75.19 E-value: 7.64e-18

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDADLAPIVLLARL---KENTAPIIVHCSAGIGRTGSIVLIQHAME-LLHLPAPLLEISTYLIELRK 76
Cdd:cd17658  110 LHIQYPEWPDHGVPKDTRSVRELLKRLygiPPSAGPIVVHCSAGIGRTGAYCTIHNTIRrILEGDMSAVDLSKTVRKFRS 189

                         90
                 ....*....|....*.
gi 597894931  77 QRNNSIQTEHQYLYIH 92
Cdd:cd17658  190 QRIGMVQTQDQYIFCY 205

R-PTPc-A-1

cd14621

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1; Receptor-type ...

2-96

1.10e-17

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 1; Receptor-type tyrosine-protein phosphatase A (PTPRA), also known as receptor-type tyrosine-protein phosphatase alpha (R-PTP-alpha), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA is a positive regulator of Src and Src family kinases via dephosphorylation of the Src-inhibitory tyrosine 527. Thus, it affects transformation and tumorigenesis, inhibition of proliferation, cell cycle arrest, integrin signaling, neuronal differentiation and outgrowth, and ion channel activity. It is also involved in interleukin-1 signaling in fibroblasts through its interaction with the focal adhesion targeting domain of focal adhesion kinase. PTPRA comprises a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the first catalytic PTP domain (repeat 1).

Pssm-ID: 350469 [Multi-domain] Cd Length: 296 Bit Score: 76.60 E-value: 1.10e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPdadLAPIVLLARLKENTA-------PIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEISTYLIEL 74
Cdd:cd14621  189 QFHFTSWPDFGVP---FTPIGMLKFLKKVKNcnpqyagAIVVHCSAGVGRTGTFIVIDAMLDMMHAERK-VDVYGFVSRI 264

                         90       100
                 ....*....|....*....|..
gi 597894931  75 RKQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14621  265 RAQRCQMVQTDMQYVFIYQALL 286

PTPc-N6

cd14606

catalytic domain of tyrosine-protein phosphatase non-receptor type 6; Tyrosine-protein ...

2-100

1.23e-17

catalytic domain of tyrosine-protein phosphatase non-receptor type 6; Tyrosine-protein phosphatase non-receptor type 6 (PTPN6), also called SH2 domain-containing protein-tyrosine phosphatase 1 (SHP1 or SHP-1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN6 expression is restricted mainly to hematopoietic and epithelial cells. It is an important regulator of hematopoietic cells, downregulating pathways that promote cell growth, survival, adhesion, and activation. It regulates glucose homeostasis by modulating insulin signalling in the liver and muscle, and it also negatively regulates bone resorption, affecting both the formation and the function of osteoclasts. PTPN6 contains two tandem SH2 domains, a catalytic PTP domain, and a C-terminal tail with regulatory properties.

Pssm-ID: 350454 [Multi-domain] Cd Length: 266 Bit Score: 76.07 E-value: 1.23e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAdlaPIVLLARLKE---------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPA--PLLEISTY 70
Cdd:cd14606  159 HYQYLSWPDHGVPSE---PGGVLSFLDQinqrqeslpHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGldCDIDIQKT 235

                         90       100       110
                 ....*....|....*....|....*....|
gi 597894931  71 LIELRKQRNNSIQTEHQYLYIHQVLLLYLK 100
Cdd:cd14606  236 IQMVRAQRSGMVQTEAQYKFIYVAIAQFIE 265

PTPc-N13

cd14597

catalytic domain of tyrosine-protein phosphatase non-receptor type 13; Tyrosine-protein ...

2-99

1.27e-17

catalytic domain of tyrosine-protein phosphatase non-receptor type 13; Tyrosine-protein phosphatase non-receptor type 13 (PTPN13, also known as PTPL1) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN13 is an important regulator of tumor aggressiveness. It regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. In hepatocellular carcinoma, PTPN13 is a tumor suppressor. PTPN13 contains a FERM domain, five PDZ domains, and a C-terminal catalytic PTP domain. With its PDZ domains, PTPN13 has numerous interacting partners that can actively participate in the regulation of its phosphatase activity or can permit direct or indirect recruitment of tyrosine phosphorylated substrates. Its FERM domain is necessary for localization to the membrane.

Pssm-ID: 350445 [Multi-domain] Cd Length: 234 Bit Score: 75.25 E-value: 1.27e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDA--DLAPIVLLARLKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEISTYLIELRKQRN 79
Cdd:cd14597  136 HLNFTAWPDHDTPSQpeQLLTFISYMRHIHKSGPIITHCSAGIGRSGTLICIDVVLGLISKDLD-FDISDIVRTMRLQRH 214

                         90       100
                 ....*....|....*....|
gi 597894931  80 NSIQTEHQYLYIHQVLLLYL 99
Cdd:cd14597  215 GMVQTEDQYIFCYQVILYVL 234

PTPc-N3_4

cd14541

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; ...

2-91

1.72e-17

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; Tyrosine-protein phosphatase non-receptor type 3 (PTPN3) and type 4 (PTPN4) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN3 and PTPN4 are large modular proteins containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain. PTPN3 interacts with mitogen-activated protein kinase p38gamma and serves as its specific phosphatase. PTPN4 functions in TCR cell signaling, apoptosis, cerebellar synaptic plasticity, and innate immune responses.

Pssm-ID: 350389 [Multi-domain] Cd Length: 212 Bit Score: 74.67 E-value: 1.72e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD--ADLAPIVLLARLKENTA--PIIVHCSAGIGRTGSIVLIQHAMELL--HLPAPLLEISTyliELR 75
Cdd:cd14541  110 QMQYLAWPDHGVPDdsSDFLDFVKRVRQNRVGMvePTVVHCSAGIGRTGVLITMETAMCLIeaNEPVYPLDIVR---TMR 186

                         90
                 ....*....|....*.
gi 597894931  76 KQRNNSIQTEHQYLYI 91
Cdd:cd14541  187 DQRAMLIQTPSQYRFV 202

PTPc-KIM

cd14547

catalytic domain of the kinase interaction motif (KIM) family of protein-tyrosine phosphatases; ...

2-93

1.74e-17

catalytic domain of the kinase interaction motif (KIM) family of protein-tyrosine phosphatases; The kinase interaction motif (KIM) family of protein-tyrosine phosphatases (PTPs) includes tyrosine-protein phosphatases non-receptor type 7 (PTPN7) and non-receptor type 5 (PTPN5), and protein-tyrosine phosphatase receptor type R (PTPRR). PTPN7 is also called hematopoietic protein-tyrosine phosphatase (HePTP) while PTPN5 is also called striatal-enriched protein-tyrosine phosphatase (STEP). They belong to the family of classical tyrosine-specific PTPs (EC 3.1.3.48) that catalyze the dephosphorylation of phosphotyrosine peptides. KIM-PTPs are characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. They are highly specific to the MAPKs ERK1/2 (extracellular-signal-regulated kinase 1/2) and p38, over JNK (c-Jun N-terminal kinase); they dephosphorylate these kinases and thereby critically modulate cell proliferation and differentiation.

Pssm-ID: 350395 [Multi-domain] Cd Length: 224 Bit Score: 74.74 E-value: 1.74e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADlAPIVLLARLKEN-------TAPIIVHCSAGIGRTGSIVLIQHAMELLhLPAPLLEISTYLIEL 74
Cdd:cd14547  128 HYWYTSWPDHKTPEAA-QPLLSLVQEVEEarqtephRGPIVVHCSAGIGRTGCFIATSIGCQQL-REEGVVDVLGIVCQL 205

                         90
                 ....*....|....*....
gi 597894931  75 RKQRNNSIQTEHQYLYIHQ 93
Cdd:cd14547  206 RLDRGGMVQTAEQYEFVHR 224

R-PTPc-B

cd14617

catalytic domain of receptor-type tyrosine-protein phosphatase B; Receptor-type ...

2-93

1.77e-17

catalytic domain of receptor-type tyrosine-protein phosphatase B; Receptor-type tyrosine-protein phosphatase B (PTPRB), also known as receptor-type tyrosine-protein phosphatase beta (R-PTP-beta) or vascular endothelial protein tyrosine phosphatase(VE-PTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRB/VE-PTP is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is expressed specifically in vascular endothelial cells and it plays an important role in blood vessel remodeling and angiogenesis.

Pssm-ID: 350465 [Multi-domain] Cd Length: 228 Bit Score: 74.96 E-value: 1.77e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIELR 75
Cdd:cd14617  132 HFHYTVWPDHGVPETTQSLIQFVRTVRDyinrtpGSGPTVVHCSAGVGRTGTFIALDRILQQLD-SKDSVDIYGAVHDLR 210

                         90
                 ....*....|....*...
gi 597894931  76 KQRNNSIQTEHQYLYIHQ 93
Cdd:cd14617  211 LHRVHMVQTECQYVYLHQ 228

R-PTPc-D-1

cd14624

catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1; Receptor-type ...

2-96

3.19e-17

catalytic domain of receptor-type tyrosine-protein phosphatase D, repeat 1; Receptor-type tyrosine-protein phosphatase D (PTPRD), also known as receptor-type tyrosine-protein phosphatase delta (R-PTP-delta), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules that play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. PTPRD is involved in pre-synaptic differentiation through interaction with SLITRK2. It contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the catalytic PTP domain (repeat 1).

Pssm-ID: 350472 [Multi-domain] Cd Length: 284 Bit Score: 75.15 E-value: 3.19e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIELRKQ 77
Cdd:cd14624  180 QFQFTAWPDHGVPEHPTPFLAFLRRVKTcnppDAGPMVVHCSAGVGRTGCFIVIDAMLERIK-HEKTVDIYGHVTLMRAQ 258

                         90
                 ....*....|....*....
gi 597894931  78 RNNSIQTEHQYLYIHQVLL 96
Cdd:cd14624  259 RNYMVQTEDQYIFIHDALL 277

PTPc-N21_14

cd14540

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; ...

2-99

5.15e-17

catalytic domain of tyrosine-protein phosphatase non-receptor type 21 and type 14; Tyrosine-protein phosphatase non-receptor type 21 (PTPN21) and type 14 (PTPN14) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Both PTPN21 and PTPN14 contain an N-terminal FERM domain and a C-terminal catalytic PTP domain, separated by a long intervening sequence.

Pssm-ID: 350388 [Multi-domain] Cd Length: 219 Bit Score: 73.64 E-value: 5.15e-17

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDA---------DLAPIVLLA----RLKENTAPIIVHCSAGIGRTGSIVL-------IQHAMELlhlp 61
Cdd:cd14540  110 HLQYTDWPDHGCPEDvsgfldfleEINSVRRHTnqdvAGHNRNPPTLVHCSAGVGRTGVVILadlmlycLDHNEEL---- 185

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 597894931  62 apllEISTYLIELRKQRNNSIQTEHQYLYIHQVLLLYL 99
Cdd:cd14540  186 ----DIPRVLALLRHQRMLLVQTLAQYKFVYNVLIQYL 219

R-PTPc-typeIIb-1

cd14555

catalytic domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, ...

3-96

1.26e-16

catalytic domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, repeat 1; The type II (or R2B) subfamily of receptor protein tyrosine phosphatases (RPTPs) include the prototypical member PTPmu (or PTPRM), PCP-2 (or PTPRU), PTPrho (or PTPRT), and PTPkappa (or PTPRK). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Type IIb RPTPs mediate cell-cell adhesion though homophilic interactions; their ligand is an identical molecule on an adjacent cell. No heterophilic interactions between the subfamily members have been observed. They also commonly function as tumor suppressors. They contain an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350403 [Multi-domain] Cd Length: 204 Bit Score: 72.26 E-value: 1.26e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQDWPDRGVPDADLAPIVLLARLKENT----APIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRKQR 78
Cdd:cd14555  104 FHFTGWPDHGVPYHATGLLGFIRRVKASNppsaGPIVVHCSAGAGRTGCYIVIDIMLDMAEREG-VVDIYNCVKELRSRR 182

                         90
                 ....*....|....*...
gi 597894931  79 NNSIQTEHQYLYIHQVLL 96
Cdd:cd14555  183 VNMVQTEEQYIFIHDAIL 200

PTPc-N4

cd14601

catalytic domain of tyrosine-protein phosphatase non-receptor type 4; Tyrosine-protein ...

8-96

1.26e-16

catalytic domain of tyrosine-protein phosphatase non-receptor type 4; Tyrosine-protein phosphatase non-receptor type 4 (PTPN4), also called protein-tyrosine phosphatase MEG1, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN4 functions in TCR cell signaling, apoptosis, cerebellar synaptic plasticity, and innate immune responses. It specifically inhibits the TRIF-dependent TLR4 pathway by suppressing tyrosine phosphorylation of TRAM. It is a large modular protein containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain; the PDZ domain regulates the catalytic activity of PTPN4.

Pssm-ID: 350449 [Multi-domain] Cd Length: 212 Bit Score: 72.29 E-value: 1.26e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   8 WPDRGVPD--ADLAPIVLLARLKE--NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPL--LEIstyLIELRKQRNNS 81
Cdd:cd14601  116 WPDHGVPDdsSDFLDFVCLVRNKRagKDEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVypLDI---VRTMRDQRAMM 192

                         90
                 ....*....|....*
gi 597894931  82 IQTEHQYLYIHQVLL 96
Cdd:cd14601  193 IQTPSQYRFVCEAIL 207

R-PTPc-H

cd14619

catalytic domain of receptor-type tyrosine-protein phosphatase H; Receptor-type ...

2-99

1.30e-16

catalytic domain of receptor-type tyrosine-protein phosphatase H; Receptor-type tyrosine-protein phosphatase H (PTPRH or R-PTP-H), also known as stomach cancer-associated protein tyrosine phosphatase 1 (SAP-1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRH is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is localized specifically at microvilli of the brush border in gastrointestinal epithelial cells. It plays a role in intestinal immunity by regulating CEACAM20 through tyrosine dephosphorylation. It is also a negative regulator of integrin-mediated signaling and may contribute to contact inhibition of cell growth and motility.

Pssm-ID: 350467 [Multi-domain] Cd Length: 233 Bit Score: 72.61 E-value: 1.30e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAdlaPIVLLA---------RLKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLI 72
Cdd:cd14619  131 HFHFTAWPDHGVPSS---TDTLLAfrrllrqwlDQTMSGGPTVVHCSAGVGRTGTLIALDVLLQQLQ-SEGLLGPFSFVQ 206

                         90       100
                 ....*....|....*....|....*..
gi 597894931  73 ELRKQRNNSIQTEHQYLYIHQVLLLYL 99
Cdd:cd14619  207 KMRENRPLMVQTESQYVFLHQCILDFL 233

PTPc-N12

cd14604

catalytic domain of tyrosine-protein phosphatase non-receptor type 12; Tyrosine-protein ...

2-101

1.48e-16

catalytic domain of tyrosine-protein phosphatase non-receptor type 12; Tyrosine-protein phosphatase non-receptor type 12 (PTPN12), also called PTP-PEST or protein-tyrosine phosphatase G1 (PTPG1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN12 is characterized as a tumor suppressor and a pivotal regulator of EGFR/HER2 signaling. It regulates various physiological processes, including cell migration, immune response, and neuronal activity, by dephosphorylating multiple substrates including HER2, FAK, PYK2, PSTPIP, WASP, p130Cas, paxillin, Shc, catenin, c-Abl, ArgBP2, p190RhoGAP, RhoGDI, cell adhesion kinase beta, and Rho GTPase.

Pssm-ID: 350452 [Multi-domain] Cd Length: 297 Bit Score: 73.43 E-value: 1.48e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVP---DADLAPIVLLARLKEN-TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTY-LI-ELR 75
Cdd:cd14604  190 QFHYVNWPDHDVPssfDSILDMISLMRKYQEHeDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFnLIqEMR 269

                         90       100
                 ....*....|....*....|....*.
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLLLYLKK 101
Cdd:cd14604  270 TQRHSAVQTKEQYELVHRAIAQLFEK 295

R-PTPc-C-1

cd14557

catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1; Receptor-type ...

2-93

1.71e-16

catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1; Receptor-type tyrosine-protein phosphatase C (PTPRC), also known as CD45, leukocyte common antigen (LCA) or GP180, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRC/CD45 is found in all nucleated hematopoietic cells and is an essential regulator of T- and B-cell antigen receptor signaling. It controls immune response, both positively and negatively, by dephosphorylating a number of signaling molecules such as the Src family kinases, the CD3zeta chain of TCY, and ZAP-70 kinase. Mutations in the human PTPRC/CD45 gene are associated with severe combined immunodeficiency (SCID) and multiple sclerosis. PTPRC/CD45 contains an extracellular receptor-like region with fibronectin type III (FN3) repeats, a short transmembrane segment, and a cytoplasmic region comprising of a membrane proximal catalytically active PTP domain (repeat 1 or D1) and a membrane distal catalytically impaired PTP-like domain (repeat 2, or D2). This model represents repeat 1.

Pssm-ID: 350405 [Multi-domain] Cd Length: 201 Bit Score: 71.78 E-value: 1.71e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAdlaPIVLLA-RLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIEL 74
Cdd:cd14557  107 HIQFTSWPDHGVPED---PHLLLKlRRRVNafnnffSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAEG-RVDVYGYVVKL 182

                         90
                 ....*....|....*....
gi 597894931  75 RKQRNNSIQTEHQYLYIHQ 93
Cdd:cd14557  183 RRQRCLMVQVEAQYILIHQ 201

PTPc-N21

cd14598

catalytic domain of tyrosine-protein phosphatase non-receptor type 21; Tyrosine-protein ...

2-100

1.75e-16

catalytic domain of tyrosine-protein phosphatase non-receptor type 21; Tyrosine-protein phosphatase non-receptor type 21 (PTPN21), also called protein-tyrosine phosphatase D1, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN21 is a component of a multivalent scaffold complex nucleated by focal adhesion kinase (FAK) at specific intracellular sites. It promotes cytoskeleton events that induce cell adhesion and migration by modulating Src-FAK signaling. It can also selectively associate with and stimulate Tec family kinases and modulate Stat3 activation. Human PTPN21 may also play a pathologic role in gastrointestinal tract tumorigenesis. PTPN21 contains an N-terminal FERM domain and a C-terminal catalytic PTP domain, separated by a long intervening sequence.

Pssm-ID: 350446 [Multi-domain] Cd Length: 220 Bit Score: 71.93 E-value: 1.75e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD------ADLAPIVLLARLKENTA-------PIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEIS 68
Cdd:cd14598  110 HLQYTDWPEHGCPEdlkgflSYLEEIQSVRRHTNSTIdpkspnpPVLVHCSAGVGRTGVVILSEIMIACLEHNE-MLDIP 188

                         90       100       110
                 ....*....|....*....|....*....|..
gi 597894931  69 TYLIELRKQRNNSIQTEHQYLYIHQVLLLYLK 100
Cdd:cd14598  189 RVLDMLRQQRMMMVQTLSQYTFVYKVLIQFLK 220

R-PTPc-U-1

cd14632

catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1; Receptor-type ...

2-96

2.60e-16

catalytic domain of receptor-type tyrosine-protein phosphatase U, repeat 1; Receptor-type tyrosine-protein phosphatase U (PTPRU), also known as pancreatic carcinoma phosphatase 2 (PCP-2), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRU/PCP-2 is the most distant member of the type IIb subfamily and may have a distinct biological function other than cell-cell aggregation. It localizes to the adherens junctions and directly binds and dephosphorylates beta-catenin, and regulates the balance between signaling and adhesive beta-catenin. It plays an important role in the maintenance of epithelial integrity. PTPRU contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350480 [Multi-domain] Cd Length: 205 Bit Score: 71.24 E-value: 2.60e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENT----APIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRKQ 77
Cdd:cd14632  103 QFHFTSWPEHGVPYHATGLLAFIRRVKASTppdaGPVVVHCSAGAGRTGCYIVLDVMLDMAECEG-VVDIYNCVKTLCSR 181

                         90
                 ....*....|....*....
gi 597894931  78 RNNSIQTEHQYLYIHQVLL 96
Cdd:cd14632  182 RINMIQTEEQYIFIHDAIL 200

PTPc-N1_2

cd14545

catalytic domain of tyrosine-protein phosphatase non-receptor type 1 and type 2; ...

1-87

4.50e-16

catalytic domain of tyrosine-protein phosphatase non-receptor type 1 and type 2; Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) type 2 (PTPN2) belong to the family of classical tyrosine-specific protein tyrosine phosphatases, (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN1 (or PTP-1B) is the first PTP to be purified and characterized and is the prototypical intracellular PTP found in a wide variety of human tissues. It dephosphorylates and regulates the activity of a number of receptor tyrosine kinases, including the insulin receptor, the EGF receptor, and the PDGF receptor. PTPN2 (or TCPTP), a tumor suppressor, dephosphorylates and inactivates EGFRs, Src family kinases, Janus-activated kinases (JAKs)-1 and -3, and signal transducer and activators of transcription (STATs)-1, -3 and -5, in a cell type and context-dependent manner.

Pssm-ID: 350393 [Multi-domain] Cd Length: 231 Bit Score: 71.27 E-value: 4.50e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDADLAPIVLLAR------LKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPL-LEISTYLIE 73
Cdd:cd14545  132 LHFHYTTWPDFGVPESPAAFLNFLQKvresgsLSSDVGPPVVHCSAGIGRSGTFCLVDTCLVLIEKGNPSsVDVKKVLLE 211

                         90
                 ....*....|....
gi 597894931  74 LRKQRNNSIQTEHQ 87
Cdd:cd14545  212 MRKYRMGLIQTPDQ 225

PTPc-N1

cd14608

catalytic domain of tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein ...

1-109

5.71e-16

catalytic domain of tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase non-receptor type 1 (PTPN1), also called protein-tyrosine phosphatase 1B (PTP-1B), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN1/PTP-1B is the first PTP to be purified and characterized and is the prototypical intracellular PTP found in a wide variety of human tissues. It contains an N-terminal catalytic PTP domain, followed by two tandem proline-rich motifs that mediate interaction with SH3-domain-containing proteins, and a small hydrophobic stretch that localizes the enzyme to the endoplasmic reticulum (ER). It dephosphorylates and regulates the activity of a number of receptor tyrosine kinases, including the insulin receptor, the EGF receptor, and the PDGF receptor.

Pssm-ID: 350456 [Multi-domain] Cd Length: 277 Bit Score: 71.60 E-value: 5.71e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDADLAPIVLLARLKENTA------PIIVHCSAGIGRTGSIVLIQHAMELLHL---PAPlLEISTYL 71
Cdd:cd14608  157 LHFHYTTWPDFGVPESPASFLNFLFKVRESGSlspehgPVVVHCSAGIGRSGTFCLADTCLLLMDKrkdPSS-VDIKKVL 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 597894931  72 IELRKQRNNSIQTEHQYLYIHqvlLLYLKKTKYL--DESV 109
Cdd:cd14608  236 LEMRKFRMGLIQTADQLRFSY---LAVIEGAKFImgDSSV 272

R-PTPc-K-1

cd14631

catalytic domain of receptor-type tyrosine-protein phosphatase K, repeat 1; Receptor-type ...

2-96

8.19e-16

catalytic domain of receptor-type tyrosine-protein phosphatase K, repeat 1; Receptor-type tyrosine-protein phosphatase K (PTPRK), also known as receptor-type tyrosine-protein phosphatase kappa (RPTP-kappa or PTPkappa), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRK is widely expressed and has been shown to stimulate cell motility and neurite outgrowth. It is required for anti-proliferative and pro-migratory effects of TGF-beta, suggesting a role in regulation, maintenance, and restoration of cell adhesion. It is a potential tumour suppressor in primary central nervous system lymphomas, colorectal cancer, and breast cancer. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350479 [Multi-domain] Cd Length: 218 Bit Score: 70.43 E-value: 8.19e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLK----ENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRKQ 77
Cdd:cd14631  117 QFHFTGWPDHGVPYHATGLLSFIRRVKlsnpPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREG-VVDIYNCVKALRSR 195

                         90
                 ....*....|....*....
gi 597894931  78 RNNSIQTEHQYLYIHQVLL 96
Cdd:cd14631  196 RINMVQTEEQYIFIHDAIL 214

PTPc-N3

cd14600

catalytic domain of tyrosine-protein phosphatase non-receptor type 3; Tyrosine-protein ...

2-96

9.04e-16

catalytic domain of tyrosine-protein phosphatase non-receptor type 3; Tyrosine-protein phosphatase non-receptor type 3 (PTPN3), also called protein-tyrosine phosphatase H1 (PTP-H1), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN3 interacts with mitogen-activated protein kinase p38gamma and serves as its specific phosphatase. PTPN3 and p38gamma cooperate to promote Ras-induced oncogenesis. PTPN3 is a large modular protein containing an N-terminal FERM domain, a PDZ domain and a C-terminal catalytic PTP domain. Its PDZ domain binds with the PDZ-binding motif of p38gamma and enables efficient tyrosine dephosphorylation.

Pssm-ID: 350448 [Multi-domain] Cd Length: 274 Bit Score: 71.03 E-value: 9.04e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD--ADLAPIVLLAR-LKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPL--LEISTyliELRK 76
Cdd:cd14600  173 HLQYVAWPDHGVPDdsSDFLEFVNYVRsKRVENEPVLVHCSAGIGRTGVLVTMETAMCLTERNQPVypLDIVR---KMRD 249

                         90       100
                 ....*....|....*....|
gi 597894931  77 QRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14600  250 QRAMMVQTSSQYKFVCEAIL 269

R-PTPc-T-1

cd14630

catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1; Receptor-type ...

3-96

1.39e-15

catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1; Receptor-type tyrosine-protein phosphatase T (PTPRT), also known as receptor-type tyrosine-protein phosphatase rho (RPTP-rho or PTPrho), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRT is highly expressed in the nervous system and it plays a critical role in regulation of synaptic formation and neuronal development. It dephosphorylates a specific tyrosine residue in syntaxin-binding protein 1, a key component of synaptic vesicle fusion machinery, and regulates its binding to syntaxin 1. PTPRT has been identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350478 [Multi-domain] Cd Length: 237 Bit Score: 70.05 E-value: 1.39e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQDWPDRGVPDADLAPIVLLARLK----ENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRKQR 78
Cdd:cd14630  136 FHFTSWPDHGVPCYATGLLGFVRQVKflnpPDAGPIVVHCSAGAGRTGCFIAIDIMLDMAENEG-VVDIFNCVRELRAQR 214

                         90
                 ....*....|....*...
gi 597894931  79 NNSIQTEHQYLYIHQVLL 96
Cdd:cd14630  215 VNMVQTEEQYVFVHDAIL 232

R-PTPc-M-1

cd14633

catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1; Receptor-type ...

2-96

2.23e-15

catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1; Receptor-type tyrosine-protein phosphatase M (PTPRM), also known as protein-tyrosine phosphatase mu (R-PTP-mu or PTPmu), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRM/PTPmu is a homophilic cell adhesion molecule expressed in CNS neurons and glia. It is required for E-, N-, and R-cadherin-dependent neurite outgrowth. Loss of PTPmu contributes to tumor cell migration and dispersal of human glioblastomas. PTPRM contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the first (repeat 1) PTP domain.

Pssm-ID: 350481 [Multi-domain] Cd Length: 273 Bit Score: 70.07 E-value: 2.23e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRKQ 77
Cdd:cd14633  172 QFHFTGWPDHGVPYHATGLLGFVRQVKSksppNAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREG-VVDIYNCVRELRSR 250

                         90
                 ....*....|....*....
gi 597894931  78 RNNSIQTEHQYLYIHQVLL 96
Cdd:cd14633  251 RVNMVQTEEQYVFIHDAIL 269

PTPc-N11

cd14605

catalytic domain of tyrosine-protein phosphatase non-receptor type 11; Tyrosine-protein ...

2-100

3.15e-15

catalytic domain of tyrosine-protein phosphatase non-receptor type 11; Tyrosine-protein phosphatase non-receptor type 11 (PTPN11), also called SH2 domain-containing tyrosine phosphatase 2 (SHP-2 or SHP2), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN11 promotes the activation of the RAS/Mitogen-Activated Protein Kinases (MAPK) Extracellular-Regulated Kinases 1/2 (ERK1/2) pathway, a canonical signaling cascade that plays key roles in various cellular processes, including proliferation, survival, differentiation, migration, or metabolism. It also regulates the phosphoinositide 3-kinase (PI3K)/AKT pathway, a fundamental cascade that functions in cell survival, proliferation, migration, morphogenesis, and metabolism. PTPN11 dysregulation is associated with several developmental diseases and malignancies, such as Noonan syndrome and juvenile myelomonocytic leukemia. It contains two tandem SH2 domains, a catalytic PTP domain, and a C-terminal tail with regulatory properties.

Pssm-ID: 350453 [Multi-domain] Cd Length: 253 Bit Score: 69.28 E-value: 3.15e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPdADlaPIVLLARLKE---------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEIST--Y 70
Cdd:cd14605  146 QYHFRTWPDHGVP-SD--PGGVLDFLEEvhhkqesimDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVpkT 222

                         90       100       110
                 ....*....|....*....|....*....|
gi 597894931  71 LIELRKQRNNSIQTEHQYLYIHQVLLLYLK 100
Cdd:cd14605  223 IQMVRSQRSGMVQTEAQYRFIYMAVQHYIE 252

PTPc-N20

cd14596

catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein ...

2-100

3.69e-15

catalytic domain of tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase non-receptor type 20 (PTPN20) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Human PTPN20 is a widely expressed phosphatase with a dynamic subcellular distribution that is targeted to sites of actin polymerization.

Pssm-ID: 350444 [Multi-domain] Cd Length: 207 Bit Score: 68.24 E-value: 3.69e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDA--DLAPIVLLARLKENTAPIIVHCSAGIGRTGsiVLIQHAMELLHLPAPL-LEISTYLIELRKQR 78
Cdd:cd14596  108 HLQFTTWPDHGTPQSsdQLVKFICYMRKVHNTGPIVVHCSAGIGRAG--VLICVDVLLSLIEKDLsFNIKDIVREMRQQR 185

                         90       100
                 ....*....|....*....|..
gi 597894931  79 NNSIQTEHQYLYIHQVLLLYLK 100
Cdd:cd14596  186 YGMIQTKDQYLFCYKVVLEVLQ 207

PTPc-N5

cd14613

catalytic domain of tyrosine-protein phosphatase non-receptor type 5; Tyrosine-protein ...

2-98

5.27e-15

catalytic domain of tyrosine-protein phosphatase non-receptor type 5; Tyrosine-protein phosphatase non-receptor type 5 (PTPN5), also called striatum-enriched protein-tyrosine phosphatase (STEP) or neural-specific PTP, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN5/STEP is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. It is a CNS-enriched protein that regulates key signaling proteins required for synaptic strengthening, as well as NMDA and AMPA receptor trafficking. PTPN5 is implicated in multiple neurologic and neuropsychiatric disorders, such as Alzheimer's disease, Parkinson's disease, schizophrenia, and fragile X syndrome.

Pssm-ID: 350461 [Multi-domain] Cd Length: 258 Bit Score: 68.74 E-value: 5.27e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE-------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIEL 74
Cdd:cd14613  156 HYWYTSWPDQKTPDNAPPLLQLVQEVEEarqqaepNCGPVIVHCSAGIGRTGCFIATSICCKQLR-NEGVVDILRTTCQL 234

                         90       100
                 ....*....|....*....|....
gi 597894931  75 RKQRNNSIQTEHQYLYIHQVLLLY 98
Cdd:cd14613  235 RLDRGGMIQTCEQYQFVHHVLSLY 258

PTPc-N2

cd14607

catalytic domain of tyrosine-protein phosphatase non-receptor type 2; Tyrosine-protein ...

2-87

5.90e-15

catalytic domain of tyrosine-protein phosphatase non-receptor type 2; Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also called T-cell protein-tyrosine phosphatase (TCPTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN2, a tumor suppressor, dephosphorylates and inactivates EGFRs, Src family kinases, Janus-activated kinases (JAKs)-1 and -3, and signal transducer and activators of transcription (STATs)-1, -3 and -5, in a cell type and context-dependent manner. It is deleted in 6% of all T-cell acute lymphoblastic leukemias and is associated with constitutive JAK1/STAT5 signaling and tumorigenesis.

Pssm-ID: 350455 [Multi-domain] Cd Length: 257 Bit Score: 68.45 E-value: 5.90e-15

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENTA------PIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLL-EISTYLIEL 74
Cdd:cd14607  157 HFHYTTWPDFGVPESPASFLNFLFKVRESGSlspehgPAVVHCSAGIGRSGTFSLVDTCLVLMEKKDPDSvDIKQVLLDM 236

                         90
                 ....*....|...
gi 597894931  75 RKQRNNSIQTEHQ 87
Cdd:cd14607  237 RKYRMGLIQTPDQ 249

PTPc-N9

cd14543

catalytic domain of tyrosine-protein phosphatase non-receptor type 9; Tyrosine-protein ...

3-92

1.50e-14

catalytic domain of tyrosine-protein phosphatase non-receptor type 9; Tyrosine-protein phosphatase non-receptor type 9 (PTPN9), also called protein-tyrosine phosphatase MEG2, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN9 plays an important role in promoting intracellular secretary vesicle fusion in hematopoietic cells and promotes the dephosphorylation of ErbB2 and EGFR in breast cancer cells, leading to impaired activation of STAT5 and STAT3. It also directly dephosphorylates STAT3 at the Tyr705 residue, resulting in its inactivation. PTPN9 has been found to be dysregulated in various human cancers, including breast, colorectal, and gastric cancer.

Pssm-ID: 350391 [Multi-domain] Cd Length: 271 Bit Score: 67.77 E-value: 1.50e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQ--DWPDRGVPDADLAPIVLLARLKENTA-----------------PIIVHCSAGIGRTGS-----IVLIQhameLL 58
Cdd:cd14543  163 THFQftSWPDFGVPSSAAALLDFLGEVRQQQAlavkamgdrwkghppgpPIVVHCSAGIGRTGTfctldICLSQ----LE 238

                         90       100       110
                 ....*....|....*....|....*....|....
gi 597894931  59 HLPAplLEISTYLIELRKQRNNSIQTEHQYLYIH 92
Cdd:cd14543  239 DVGT--LNVMQTVRRMRTQRAFSIQTPDQYYFCY 270

R-PTPc-J

cd14615

catalytic domain of receptor-type tyrosine-protein phosphatase J; Receptor-type ...

2-96

6.67e-14

catalytic domain of receptor-type tyrosine-protein phosphatase J; Receptor-type tyrosine-protein phosphatase J (PTPRJ or R-PTP-J), also known as receptor-type tyrosine-protein phosphatase eta (R-PTP-eta) or density-enhanced phosphatase 1 (DEP-1) OR CD148, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRJ is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats (eight in PTPRJ) and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It is expressed in various cell types including epithelial, hematopoietic, and endothelial cells. It plays a role in cell adhesion, migration, proliferation and differentiation. It dephosphorylates or contributes to the dephosphorylation of various substrates including protein kinases such as FLT3, PDGFRB, MET, RET (variant MEN2A), VEGFR-2, LYN, SRC, MAPK1, MAPK3, and EGFR, as well as PIK3R1 and PIK3R2.

Pssm-ID: 350463 [Multi-domain] Cd Length: 229 Bit Score: 65.22 E-value: 6.67e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPI----VLLARLKENT--APIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELR 75
Cdd:cd14615  129 HFHFTSWPDHGVPETTDLLInfrhLVREYMKQNPpnSPILVHCSAGVGRTGTFIAIDRLIYQIENEN-VVDVYGIVYDLR 207

                         90       100
                 ....*....|....*....|.
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14615  208 MHRPLMVQTEDQYVFLNQCAL 228

R-PTP-LAR-2

cd14554

PTP-like domain of the LAR family receptor-type tyrosine-protein phosphatases, repeat 2; The ...

3-96

8.33e-14

PTP-like domain of the LAR family receptor-type tyrosine-protein phosphatases, repeat 2; The LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs) include three vertebrate members: LAR (or PTPRF), R-PTP-delta (or PTPRD), and R-PTP-sigma (or PTPRS). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules; they bind to distinct synaptic membrane proteins and are physiologically responsible for mediating presynaptic development by shaping various synaptic adhesion pathways. They play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. LAR-RPTPs contain an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2).

Pssm-ID: 350402 [Multi-domain] Cd Length: 238 Bit Score: 65.24 E-value: 8.33e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQDWPDRGVP---DADLAPIVLLARLKEN---TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRK 76
Cdd:cd14554  140 FQFTDWPEQGVPksgEGFIDFIGQVHKTKEQfgqEGPITVHCSAGVGRTGVFITLSIVLERMRYEG-VVDVFQTVKLLRT 218

                         90       100
                 ....*....|....*....|
gi 597894931  77 QRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14554  219 QRPAMVQTEDQYQFCYRAAL 238

PTPc-N7

cd14612

catalytic domain of tyrosine-protein phosphatase non-receptor type 7; Tyrosine-protein ...

2-98

9.77e-14

catalytic domain of tyrosine-protein phosphatase non-receptor type 7; Tyrosine-protein phosphatase non-receptor type 7 (PTPN7), also called hematopoietic protein-tyrosine phosphatase (HePTP) or LC-PTP. belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN7/HePTP is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. PTPN7/HePTP is found exclusively in the white blood cells in bone marrow, thymus, spleen, lymph nodes and all myeloid and lymphoid cell lines. It negatively regulates T-cell activation and proliferation, and is often dysregulated in the preleukemic disorder myelodysplastic syndrome, as well as in acute myelogenous leukemia.

Pssm-ID: 350460 [Multi-domain] Cd Length: 247 Bit Score: 65.24 E-value: 9.77e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKE------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLEISTYLIELR 75
Cdd:cd14612  146 HYWFSSWPDHQTPESAGPLLRLVAEVEEsrqtaaSPGPIVVHCSAGIGRTGCFIATSIGCQQLKDTGK-VDILGIVCQLR 224

                         90       100
                 ....*....|....*....|...
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLLLY 98
Cdd:cd14612  225 LDRGGMIQTSEQYQFLHHTLALY 247

R-PTPc-Q

cd14616

catalytic domain of receptor-type tyrosine-protein phosphatase Q; Receptor-type ...

2-93

1.24e-13

catalytic domain of receptor-type tyrosine-protein phosphatase Q; Receptor-type tyrosine-protein phosphatase Q (PTPRQ or R-PTP-Q), also called phosphatidylinositol phosphatase PTPRQ, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRQ is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats (18 in PTPRQ) and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. It displays low tyrosine-protein phosphatase activity; rather, it functions as a phosphatidylinositol phosphatase required for auditory processes. It regulates the levels of phosphatidylinositol 4,5-bisphosphate (PIP2) in the basal region of hair bundles. It can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates.

Pssm-ID: 350464 [Multi-domain] Cd Length: 224 Bit Score: 64.54 E-value: 1.24e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD--ADLAPIVLLARLK--ENTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIELRKQ 77
Cdd:cd14616  130 QCNFTSWPEHGVPEssAPLIHFVKLVRASraHDNTPMIVHCSAGVGRTGVFIALDHLTQHIN-DHDFVDIYGLVAELRSE 208

                         90
                 ....*....|....*.
gi 597894931  78 RNNSIQTEHQYLYIHQ 93
Cdd:cd14616  209 RMCMVQNLAQYIFLHQ 224

R-PTPc-A-E-2

cd14552

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 2; ...

2-95

2.11e-13

catalytic domain of receptor-type tyrosine-protein phosphatase A and E, repeat 2; Receptor-type tyrosine-protein phosphatase A (PTPRA) and E (PTPRE) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA and PTPRE share several functions including regulation of Src family kinases and voltage-gated potassium (Kv) channels. They both contain a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the second PTP domain (repeat 2).

Pssm-ID: 350400 [Multi-domain] Cd Length: 202 Bit Score: 63.83 E-value: 2.11e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKEN-----TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRK 76
Cdd:cd14552  104 QFHFHGWPEVGIPDNGKGMIDLIAAVQKQqqqsgNHPITVHCSAGAGRTGTFCALSTVLERVKAEG-VLDVFQVVKSLRL 182

                         90
                 ....*....|....*....
gi 597894931  77 QRNNSIQTEHQYLYIHQVL 95
Cdd:cd14552  183 QRPHMVQTLEQYEFCYKVV 201

COG5599

Protein tyrosine phosphatase [Signal transduction mechanisms];

2-88

2.81e-13

Protein tyrosine phosphatase [Signal transduction mechanisms];

Pssm-ID: 444335 [Multi-domain] Cd Length: 282 Bit Score: 64.34 E-value: 2.81e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAD-LAPIVLLARLKENTA-----PIIVHCSAGIGRTGSIVLIqHAME--LLHLPAPLLEISTYLIE 73
Cdd:COG5599  171 VLHVKNWPDHGAISAEaLKNLADLIDKKEKIKdpdklLPVVHCRAGVGRTGTLIAC-LALSksINALVQITLSVEEIVID 249

                         90
                 ....*....|....*.
gi 597894931  74 LRKQRNNSI-QTEHQY 88
Cdd:COG5599  250 MRTSRNGGMvQTSEQL 265

PHA02742

protein tyrosine phosphatase; Provisional

2-100

3.10e-13

protein tyrosine phosphatase; Provisional

Pssm-ID: 165109 [Multi-domain] Cd Length: 303 Bit Score: 64.25 E-value: 3.10e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD--ADLAPIVLLARLKENTA-------------PIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLE 66
Cdd:PHA02742 185 HFAYEDWPHGGLPRdpNKFLDFVLAVREADLKAdvdikgenivkepPILVHCSAGLDRAGAFCAIDICISKYNERA-IIP 263

                         90       100       110
                 ....*....|....*....|....*....|....
gi 597894931  67 ISTYLIELRKQRNNSIQTEHQYLYIHQVLLLYLK 100
Cdd:PHA02742 264 LLSIVRDLRKQRHNCLSLPQQYIFCYFIVLIFAK 297

R-PTP-S-2

cd14627

PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2; Receptor-type ...

2-99

3.54e-13

PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2; Receptor-type tyrosine-protein phosphatase S (PTPRS), also known as receptor-type tyrosine-protein phosphatase sigma (R-PTP-sigma), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRS is a receptor for glycosaminoglycans, including heparan sulfate proteoglycan and neural chondroitin sulfate proteoglycans (CSPGs), which present a barrier to axon regeneration. It also plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. PTPRS contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2). Although described as non-catalytic, this domain contains the catalytic cysteine and the active site signature motif, HCSAGxGRxG.

Pssm-ID: 350475 [Multi-domain] Cd Length: 290 Bit Score: 63.98 E-value: 3.54e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENT------APIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELR 75
Cdd:cd14627  186 QFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFITLSIVLERMRYEG-VVDIFQTVKMLR 264

                         90       100
                 ....*....|....*....|....
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLLLYL 99
Cdd:cd14627  265 TQRPAMVQTEDEYQFCYQAALEYL 288

R-PTPc-E-2

cd14622

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 2; Receptor-type ...

2-95

4.72e-13

catalytic domain of receptor-type tyrosine-protein phosphatase E, repeat 2; Receptor-type tyrosine-protein phosphatase E (PTPRE), also known as receptor-type tyrosine-protein phosphatase epsilon (R-PTP-epsilon), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. The PTPRE gene contains two distinct promoters that generate the two major isoforms: transmembrane (receptor type RPTPe or PTPeM) and cytoplasmic (cyt-PTPe or PTPeC). Receptor type RPTPe plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells, and may also play a role in osteoclast formation and function. It also negatively regulates PDGFRbeta-mediated signaling pathways that are crucial for the pathogenesis of atherosclerosis. cyt-PTPe acts as a negative regulator of insulin receptor signaling in skeletal muscle. It regulates insulin-induced phosphorylation of proteins downstream of the insulin receptor. Receptor type RPTPe contains a small extracellular region, a single transmembrane segment, and an intracellular region two tandem catalytic PTP domains. This model represents the second PTP domain (repeat 2).

Pssm-ID: 350470 [Multi-domain] Cd Length: 205 Bit Score: 62.72 E-value: 4.72e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENTA-----PIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRK 76
Cdd:cd14622  105 QFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQqtgnhPIVVHCSAGAGRTGTFIALSNILERVKAEG-LLDVFQTVKSLRL 183

                         90
                 ....*....|....*....
gi 597894931  77 QRNNSIQTEHQYLYIHQVL 95
Cdd:cd14622  184 QRPHMVQTLEQYEFCYRVV 202

R-PTPc-R

cd14611

catalytic domain of receptor-type tyrosine-protein phosphatase R; Receptor-type ...

2-93

4.83e-13

catalytic domain of receptor-type tyrosine-protein phosphatase R; Receptor-type tyrosine-protein phosphatase-like R (PTPRR or R-PTP-R), also called protein-tyrosine phosphatase PCPTP1, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRR is a kinase interaction motif (KIM)-PTP, characterized by the presence of a 16-amino-acid KIM that binds specifically to members of the MAPK (mitogen-activated protein kinase) family. The human and mouse PTPRR gene produces multiple neuronal protein isoforms of varying sizes (in human, PTPPBS-alpha, beta, gamma and delta). All isoforms contain the KIM motif and the catalytic PTP domain. PTPRR-deficient mice show significant defects in fine motor coordination and balance skills that are reminiscent of a mild ataxia.

Pssm-ID: 350459 [Multi-domain] Cd Length: 226 Bit Score: 63.01 E-value: 4.83e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELR 75
Cdd:cd14611  130 HYWYTSWPDHKTPDSAQPLLQLMLDVEEDrlaspgRGPVVVHCSAGIGRTGCFIATTIGCQQLKEEG-VVDVLSIVCQLR 208

                         90
                 ....*....|....*...
gi 597894931  76 KQRNNSIQTEHQYLYIHQ 93
Cdd:cd14611  209 VDRGGMVQTSEQYEFVHH 226

R-PTP-N2

cd14610

PTP-like domain of receptor-type tyrosine-protein phosphatase N2; Receptor-type ...

2-88

5.44e-13

PTP-like domain of receptor-type tyrosine-protein phosphatase N2; Receptor-type tyrosine-protein phosphatase N2 (PTPRN2 or R-PTP-N2), also called islet cell autoantigen-related protein (IAR), ICAAR, phogrin, or IA-2beta, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). It consists of a large ectodomain that contains a RESP18HD (regulated endocrine-specific protein 18 homology domain), followed by a transmembrane segment, and a single, catalytically-impaired, PTP domain. It is mainly expressed in neuropeptidergic neurons and peptide-secreting endocrine cells, including insulin-producing pancreatic beta-cells. It may function as a phosphatidylinositol phosphatase to regulate insulin secretion. It is also required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain.

Pssm-ID: 350458 [Multi-domain] Cd Length: 283 Bit Score: 63.54 E-value: 5.44e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAdlAPIVLLARLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLIELR 75
Cdd:cd14610  179 QFHFLSWNDQGVPAS--TRSLLDFRRKVNkcyrgrSCPIIVHCSDGAGRSGTYILIDMVLNKMAKGAKEIDIAATLEHLR 256

                         90
                 ....*....|...
gi 597894931  76 KQRNNSIQTEHQY 88
Cdd:cd14610  257 DQRPGMVQTKEQF 269

R-PTP-D-2

cd14628

PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2; Receptor-type ...

2-99

7.32e-13

PTP-like domain of receptor-type tyrosine-protein phosphatase D, repeat 2; Receptor-type tyrosine-protein phosphatase-like D (PTPRD), also known as receptor-type tyrosine-protein phosphatase delta (R-PTP-delta), belongs to the LAR (leukocyte common antigen-related) family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. LAR-RPTPs are synaptic adhesion molecules that play roles in various aspects of neuronal development, including axon guidance, neurite extension, and synapse formation and function. PTPRD is involved in pre-synaptic differentiation through interaction with SLITRK2. It contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2). Although described as non-catalytic, this domain contains the catalytic cysteine and the active site signature motif, HCSAGxGRxG.

Pssm-ID: 350476 [Multi-domain] Cd Length: 292 Bit Score: 63.21 E-value: 7.32e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENT------APIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELR 75
Cdd:cd14628  185 QFQFTDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPISVHCSAGVGRTGVFITLSIVLERMRYEG-VVDIFQTVKMLR 263

                         90       100
                 ....*....|....*....|....
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLLLYL 99
Cdd:cd14628  264 TQRPAMVQTEDQYQFCYRAALEYL 287

PTP-N23

cd14539

PTP-like domain of tyrosine-protein phosphatase non-receptor type 23; Tyrosine-protein ...

2-93

1.02e-12

PTP-like domain of tyrosine-protein phosphatase non-receptor type 23; Tyrosine-protein phosphatase non-receptor type 23 (PTPN23), also called His domain-containing protein tyrosine phosphatase (HD-PTP) or protein tyrosine phosphatase TD14 (PTP-TD14), is a catalytically inactive member of the tyrosine-specific protein tyrosine phosphatase (PTP) family. Human PTPN23 may be involved in the regulation of small nuclear ribonucleoprotein assembly and pre-mRNA splicing by modifying the survival motor neuron (SMN) complex. It plays a role in ciliogenesis and is part of endosomal sorting complex required for transport (ESCRT) pathways. PTPN23 contains five domains: a BRO1-like domain that plays a role in endosomal sorting; a V-domain that interacts with Lys63-linked polyubiquitinated substrates; a central proline-rich region that might recruit SH3-containing proteins; a PTP-like domain; and a proteolytic degradation-targeting motif, also known as a PEST sequence.

Pssm-ID: 350387 [Multi-domain] Cd Length: 205 Bit Score: 61.63 E-value: 1.02e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDAdlaPIVLLARLKENT----------APIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYL 71
Cdd:cd14539  107 HLQFTTWPELGLPDS---PNPLLRFIEEVHshylqqrslqTPIVVHCSSGVGRTGAFCLLYAAVQEIEAGNGIPDLPQLV 183

                         90       100
                 ....*....|....*....|..
gi 597894931  72 IELRKQRNNSIQTEHQYLYIHQ 93
Cdd:cd14539  184 RKMRQQRKYMLQEKEHLKFCYE 205

R-PTPc-V

cd14618

catalytic domain of receptor-type tyrosine-protein phosphatase V; Receptor-type ...

2-96

1.30e-12

catalytic domain of receptor-type tyrosine-protein phosphatase V; Receptor-type tyrosine-protein phosphatase V (PTPRV or R-PTP-V), also known as embryonic stem cell protein-tyrosine phosphatase (ES cell phosphatase) or osteotesticular protein-tyrosine phosphatase (OST-PTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRV is a member of the R3 subfamily of receptor-type phosphotyrosine phosphatases (RPTP), characterized by a unique modular composition consisting of multiple extracellular fibronectin type III (FN3) repeats and a single (most RPTP subtypes have two) cytoplasmic catalytic PTP domain. In rodents, it may play a role in the maintenance of pluripotency and may function in signaling pathways during bone remodeling. It is the only PTP whose function has been lost between rodent and human. The human OST-PTP gene is a pseudogene.

Pssm-ID: 350466 [Multi-domain] Cd Length: 230 Bit Score: 61.88 E-value: 1.30e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDA--DLAPIVLLARLKENTA----PIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIELR 75
Cdd:cd14618  131 HLHYTAWPDHGIPEStsSLMAFRELVREHVQATkgkgPTLVHCSAGVGRSGTFIALDRLLRQLK-EEKVVDVFNTVYILR 209

                         90       100
                 ....*....|....*....|.
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14618  210 MHRYLMIQTLSQYIFLHSCIL 230

PHA02746

protein tyrosine phosphatase; Provisional

2-95

3.55e-12

protein tyrosine phosphatase; Provisional

Pssm-ID: 165113 [Multi-domain] Cd Length: 323 Bit Score: 61.58 E-value: 3.55e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPdADLAPIVLL--------ARLK-------ENTAPIIVHCSAGIGRTGSIVLIQHAMELLH------L 60
Cdd:PHA02746 204 HFWFPDWPDNGIP-TGMAEFLELinkvneeqAELIkqadndpQTLGPIVVHCSAGIGRAGTFCAIDNALEQLEkekevcL 282

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 597894931  61 PAPLLEIstylielRKQRNNSIQTEHQYLYIHQVL 95
Cdd:PHA02746 283 GEIVLKI-------RKQRHSSVFLPEQYAFCYKAL 310

R-PTP-N-N2

cd14546

PTP-like domain of receptor-type tyrosine-protein phosphatase-like N and N2; Receptor-type ...

3-88

3.61e-12

PTP-like domain of receptor-type tyrosine-protein phosphatase-like N and N2; Receptor-type tyrosine-protein phosphatase-like N (PTPRN) and N2 (PTPRN2) belong to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). They consist of a large ectodomain that contains a RESP18HD (regulated endocrine-specific protein 18 homology domain), followed by a transmembrane segment, and a single, catalytically-impaired, PTP domain. They are mainly expressed in neuropeptidergic neurons and peptide-secreting endocrine cells, including insulin-producing pancreatic beta-cells, and are involved in involved in the generation, cargo storage, traffic, exocytosis and recycling of insulin secretory granules, as well as in beta-cell proliferation. They also are major autoantigens in type 1 diabetes and are involved in the regulation of insulin secretion.

Pssm-ID: 350394 [Multi-domain] Cd Length: 208 Bit Score: 60.54 E-value: 3.61e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQDWPDRGVPdADLAPIvLLARLKEN------TAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLIELRK 76
Cdd:cd14546  107 FHFLSWPDEGIP-ASAKPL-LEFRRKVNksyrgrSCPIVVHCSDGAGRTGTYILIDMVLNRMAKGAKEIDIAATLEHLRD 184

                         90
                 ....*....|..
gi 597894931  77 QRNNSIQTEHQY 88
Cdd:cd14546  185 QRPGMVKTKDQF 196

PHA02738

hypothetical protein; Provisional

2-102

4.88e-12

hypothetical protein; Provisional

Pssm-ID: 222923 [Multi-domain] Cd Length: 320 Bit Score: 61.09 E-value: 4.88e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPD--ADLAPIVLLAR-----LKENT----------APIIVHCSAGIGRTGSIVLIQHAMELLHLPAPl 64
Cdd:PHA02738 181 HFNFTAWPDHDVPKntSEFLNFVLEVRqcqkeLAQESlqighnrlqpPPIVVHCNAGLGRTPCYCVVDISISRFDACAT- 259

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 597894931  65 LEISTYLIELRKQRNNSIQTEHQYLYIHQVLLLYLKKT 102
Cdd:PHA02738 260 VSIPSIVSSIRNQRYYSLFIPFQYFFCYRAVKRYVNLT 297

R-PTP-F-2

cd14629

PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2; Receptor-type ...

2-99

5.46e-12

PTP-like domain of receptor-type tyrosine-protein phosphatase F, repeat 2; Receptor-type tyrosine-protein phosphatase F (PTPRF), also known as leukocyte common antigen related (LAR), is the prototypical member of the LAR family of receptor-type tyrosine-protein phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRF/LAR plays a role for LAR in cadherin complexes where it associates with and dephosphorylates beta-catenin, a pathway which may be critical for cadherin complex stability and cell-cell association. It also regulates focal adhesions through cyclin-dependent kinase-1 and is involved in axon guidance in the developing nervous system. It also functions in regulating insulin signaling. PTPRF contains an extracellular region with three immunoglobulin-like (Ig) domains and four to eight fibronectin type III (FN3) repeats (determined by alternative splicing), a single transmembrane domain, followed by an intracellular region with a membrane-proximal catalytic PTP domain (repeat 1, also called D1) and a membrane-distal non-catalytic PTP-like domain (repeat 2, also called D2). This model represents the non-catalytic PTP-like domain (repeat 2). Although described as non-catalytic, this domain contains the catalytic cysteine and the active site signature motif, HCSAGxGRxG.

Pssm-ID: 350477 [Multi-domain] Cd Length: 291 Bit Score: 60.89 E-value: 5.46e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENT------APIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELR 75
Cdd:cd14629  186 QFQFTDWPEQGVPKTGEGFIDFIGQVHKTKeqfgqdGPITVHCSAGVGRTGVFITLSIVLERMRYEG-VVDMFQTVKTLR 264

                         90       100
                 ....*....|....*....|....
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLLLYL 99
Cdd:cd14629  265 TQRPAMVQTEDQYQLCYRAALEYL 288

PTPc-N22

cd14602

catalytic domain of tyrosine-protein phosphatase non-receptor type 22; Tyrosine-protein ...

3-96

1.14e-11

catalytic domain of tyrosine-protein phosphatase non-receptor type 22; Tyrosine-protein phosphatase non-receptor type 22 (PTPN22), also called lymphoid phosphatase (LyP), PEST-domain phosphatase (PEP), or hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN22 is expressed in hematopoietic cells and it functions as a key regulator of immune homeostasis by inhibiting T-cell receptor signaling through the direct dephosphorylation of Src family kinases (Lck and Fyn), ITAMs of the TCRz/CD3 complex, and other signaling molecules. Mutations in the PTPN22 gene are associated with multiple connective tissue and autoimmune diseases including type 1 diabetes mellitus, rheumatoid arthritis, and systemic lupus erythematosus. PTPN22 contains an N-terminal catalytic PTP domain and four proline-rich regions at the C-terminus.

Pssm-ID: 350450 [Multi-domain] Cd Length: 234 Bit Score: 59.47 E-value: 1.14e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQDWPDRGVPDAdLAPIVLL---ARL--KENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLI--ELR 75
Cdd:cd14602  132 FHYKNWPDHDVPSS-IDPILELiwdVRCyqEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLiqEMR 210

                         90       100
                 ....*....|....*....|.
gi 597894931  76 KQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14602  211 TQRPSLVQTKEQYELVYNAVI 231

R-PTPc-A-2

cd14623

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2; Receptor-type ...

2-95

2.84e-11

catalytic domain of receptor-type tyrosine-protein phosphatase A, repeat 2; Receptor-type tyrosine-protein phosphatase A (PTPRA), also known as receptor-type tyrosine-protein phosphatase alpha (R-PTP-alpha), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRA is a positive regulator of Src and Src family kinases via dephosphorylation of the Src-inhibitory tyrosine 527. Thus, it affects transformation and tumorigenesis, inhibition of proliferation, cell cycle arrest, integrin signaling, neuronal differentiation and outgrowth, and ion channel activity. It is also involved in interleukin-1 signaling in fibroblasts through its interaction with the focal adhesion targeting domain of focal adhesion kinase. PTPRA comprises a small extracellular domain, a transmembrane segment, and an intracellular region containing two tandem catalytic PTP domains. This model represents the second PTP domain (repeat 2).

Pssm-ID: 350471 [Multi-domain] Cd Length: 228 Bit Score: 58.13 E-value: 2.84e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENTA-----PIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELRK 76
Cdd:cd14623  129 QFHFHGWPEVGIPSDGKGMINIIAAVQKQQQqsgnhPITVHCSAGAGRTGTFCALSTVLERVKAEG-ILDVFQTVKSLRL 207

                         90
                 ....*....|....*....
gi 597894931  77 QRNNSIQTEHQYLYIHQVL 95
Cdd:cd14623  208 QRPHMVQTLEQYEFCYKVV 226

R-PTP-N

cd14609

PTP-like domain of receptor-type tyrosine-protein phosphatase N; Receptor-type ...

2-88

9.53e-11

PTP-like domain of receptor-type tyrosine-protein phosphatase N; Receptor-type tyrosine-protein phosphatase-like N (PTPRN or R-PTP-N), also called islet cell antigen 512 (ICA512) or PTP IA-2, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). It consists of a large ectodomain that contains a RESP18HD (regulated endocrine-specific protein 18 homology domain), followed by a transmembrane segment, and a single, catalytically-impaired, PTP domain. PTPRN is located in secretory granules of neuroendocrine cells and is involved in the generation, cargo storage, traffic, exocytosis and recycling of insulin secretory granules, as well as in beta-cell proliferation. It is a major autoantigen in type 1 diabetes and is involved in the regulation of insulin secretion.

Pssm-ID: 350457 [Multi-domain] Cd Length: 281 Bit Score: 57.35 E-value: 9.53e-11

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPdADLAPIVLLAR-----LKENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPAPLLEISTYLIELRK 76
Cdd:cd14609  177 QFHFLSWPAEGIP-SSTRPLLDFRRkvnkcYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRD 255

                         90
                 ....*....|..
gi 597894931  77 QRNNSIQTEHQY 88
Cdd:cd14609  256 QRPGMVRTKDQF 267

CDC14

COG2453

Protein-tyrosine phosphatase [Signal transduction mechanisms];

1-93

3.45e-09

Protein-tyrosine phosphatase [Signal transduction mechanisms];

Pssm-ID: 441989 [Multi-domain] Cd Length: 140 Bit Score: 51.12 E-value: 3.45e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPD-ADLAPIV--LLARLKENtAPIIVHCSAGIGRTGSIVliqhAMELLHLPAPLLEIstyLIELRKQ 77
Cdd:COG2453   48 LEYLHLPIPDFGAPDdEQLQEAVdfIDEALREG-KKVLVHCRGGIGRTGTVA----AAYLVLLGLSAEEA---LARVRAA 119

                         90
                 ....*....|....*.
gi 597894931  78 RNNSIQTEHQYLYIHQ 93
Cdd:COG2453  120 RPGAVETPAQRAFLER 135

CDKN3-like

cd14505

cyclin-dependent kinase inhibitor 3 and similar proteins; This family is composed of ...

1-93

5.47e-08

cyclin-dependent kinase inhibitor 3 and similar proteins; This family is composed of eukaryotic cyclin-dependent kinase inhibitor 3 (CDKN3) and related archaeal and bacterial proteins. CDKN3 is also known as kinase-associated phosphatase (KAP), CDK2-associated dual-specificity phosphatase, cyclin-dependent kinase interactor 1 (CDI1), or cyclin-dependent kinase-interacting protein 2 (CIP2). It has been characterized as dual-specificity phosphatase, which function as a protein-serine/threonine phosphatase (EC 3.1.3.16) and protein-tyrosine-phosphatase (EC 3.1.3.48). It dephosphorylates CDK2 at a threonine residue in a cyclin-dependent manner, resulting in the inhibition of G1/S cell cycle progression. It also interacts with CDK1 and controls progression through mitosis by dephosphorylating CDC2. CDKN3 may also function as a tumor suppressor; its loss of function was found in a variety of cancers including glioblastoma and hepatocellular carcinoma. However, it has also been found over-expressed in many cancers such as breast, cervical, lung and prostate cancers, and may also have an oncogenic function.

Pssm-ID: 350355 [Multi-domain] Cd Length: 163 Bit Score: 48.41 E-value: 5.47e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   1 MHYHWQDWPDRGVPDADLAPIVLLARLK---ENTAPIIVHCSAGIGRTGSIvliqhAMELLHLPAPLLEISTYLIELRKQ 77
Cdd:cd14505   73 ITWHHLPIPDGGVPSDIAQWQELLEELLsalENGKKVLIHCKGGLGRTGLI-----AACLLLELGDTLDPEQAIAAVRAL 147

                         90
                 ....*....|....*.
gi 597894931  78 RNNSIQTEHQYLYIHQ 93
Cdd:cd14505  148 RPGAIQTPKQENFLHQ 163

PHA02747

protein tyrosine phosphatase; Provisional

2-107

2.27e-07

protein tyrosine phosphatase; Provisional

Pssm-ID: 165114 [Multi-domain] Cd Length: 312 Bit Score: 47.69 E-value: 2.27e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPdADLAPIV----LLARLKENT-----------APIIVHCSAGIGRTGSIVLIQHAMELLHLPAPlLE 66
Cdd:PHA02747 186 HFQCSEWFEDETP-SDHPDFIkfikIIDINRKKSgklfnpkdallCPIVVHCSDGVGKTGIFCAVDICLNQLVKRKA-IC 263

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 597894931  67 ISTYLIELRKQRNNSIQTEHQYLYI---HQVLLLYLKKTKYLDE 107
Cdd:PHA02747 264 LAKTAEKIREQRHAGIMNFDDYLFIqpgYEVLHYFLSKIKAIDK 307

PTP_YopH-like

cd14559

YopH and related bacterial protein tyrosine phosphatases; Yersinia outer protein H (YopH) ...

3-88

2.29e-06

YopH and related bacterial protein tyrosine phosphatases; Yersinia outer protein H (YopH) belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. YopH is an essential virulence determinant of the pathogenic bacterium by dephosphorylating several focal adhesion proteins including p130Cas in human epithelial cells, resulting in the disruption of focal adhesions and cell detachment from the extracellular matrix. It contains an N-terminal domain that contains signals required for TTSS-mediated delivery of YopH into host cells and a C-terminal catalytic PTP domain.

Pssm-ID: 350407 [Multi-domain] Cd Length: 227 Bit Score: 44.70 E-value: 2.29e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   3 YHWQDWPDRGVPDAD----LAPIVLLARLKENTA----------------PIIvHCSAGIGRTGSIVLiqhAMELLHlPA 62
Cdd:cd14559  121 VHVTNWPDHTAISSEglkeLADLVNKSAEEKRNFykskgssaindknkllPVI-HCRAGVGRTGQLAA---AMELNK-SP 195

                         90       100
                 ....*....|....*....|....*..
gi 597894931  63 PLLEISTYLIELRKQRNNSI-QTEHQY 88
Cdd:cd14559  196 NNLSVEDIVSDMRTSRNGKMvQKDEQL 222

R-PTP-C-2

cd14558

PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2; Receptor-type ...

2-90

7.67e-06

PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2; Receptor-type tyrosine-protein phosphatase C (PTPRC), also known as CD45, leukocyte common antigen (LCA) or GP180, belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRC/CD45 is found in all nucleated hematopoietic cells and is an essential regulator of T- and B-cell antigen receptor signaling. It controls immune response, both positively and negatively, by dephosphorylating a number of signaling molecules such as the Src family kinases, the CD3zeta chain of TCY, and ZAP-70 kinase. Mutations in the human PTPRC/CD45 gene are associated with severe combined immunodeficiency (SCID) and multiple sclerosis. PTPRC/CD45 contains an extracellular receptor-like region with fibronectin type III (FN3) repeats, a short transmembrane segment, and a cytoplasmic region comprising of a membrane proximal catalytically active PTP domain (repeat 1 or D1) and a membrane distal catalytically impaired PTP-like domain (repeat 2, or D2). This model represents repeat 2.

Pssm-ID: 350406 [Multi-domain] Cd Length: 203 Bit Score: 43.15 E-value: 7.67e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPDRGVPDA--DLAPIVLLARLK--------ENTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYL 71
Cdd:cd14558  103 QYQYHKWKGEELPEKpkDLVDMIKSIKQKlpyknskhGRSVPIVVHCSDGSSRTGIFCALWNLLESAETEK-VVDVFQVV 181

                         90       100
                 ....*....|....*....|.
gi 597894931  72 IELRKQRNNSIQT-EH-QYLY 90
Cdd:cd14558  182 KALRKQRPGMVSTlEQyQFLY 202

PTP_DSP_cys

cd14494

cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This ...

15-93

1.51e-05

cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily; This superfamily is composed of cys-based phosphatases, which includes classical protein tyrosine phosphatases (PTPs) as well as dual-specificity phosphatases (DUSPs or DSPs). They are characterized by a CxxxxxR conserved catalytic loop (where C is the catalytic cysteine, x is any amino acid, and R is an arginine). PTPs are part of the tyrosine phosphorylation/dephosphorylation regulatory mechanism, and are important in the response of the cells to physiologic and pathologic changes in their environment. DUSPs show more substrate diversity (including RNA and lipids) and include pTyr, pSer, and pThr phosphatases.

Pssm-ID: 350344 [Multi-domain] Cd Length: 113 Bit Score: 41.18 E-value: 1.51e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931  15 DADLAPIVLLARLKENT-APIIVHCSAGIGRTGSIVLiqhAMELLHLPAPLLEIstyLIELRKQRNNSI-QTEHQYLYIH 92
Cdd:cd14494   39 LAMVDRFLEVLDQAEKPgEPVLVHCKAGVGRTGTLVA---CYLVLLGGMSAEEA---VRIVRLIRPGGIpQTIEQLDFLI 112


                 .
gi 597894931  93 Q 93
Cdd:cd14494  113 K 113

PTP_PTPDC1

cd14506

protein tyrosine phosphatase domain of PTP domain-containing protein 1; protein tyrosine ...

8-92

3.34e-05

protein tyrosine phosphatase domain of PTP domain-containing protein 1; protein tyrosine phosphatase domain-containing protein 1 (PTPDC1) is an uncharacterized non-receptor class protein-tyrosine phosphatase (PTP). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Small interfering RNA (siRNA) knockdown of the ptpdc1 gene is associated with elongated cilia.

Pssm-ID: 350356 [Multi-domain] Cd Length: 206 Bit Score: 41.18 E-value: 3.34e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   8 WPDRGVPDA----DLAPIVLLArLKENTApIIVHCSAGIGRTGsiVLIQHAMELLHLPAPLLEISTylieLRKQRNNSIQ 83
Cdd:cd14506   84 WKDYGVPSLttilDIVKVMAFA-LQEGGK-VAVHCHAGLGRTG--VLIACYLVYALRMSADQAIRL----VRSKRPNSIQ 155


                 ....*....
gi 597894931  84 TEHQYLYIH 92
Cdd:cd14506  156 TRGQVLCVR 164

R-PTPc-typeIIb-2

cd14556

PTP domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, repeat ...

2-93

7.46e-05

PTP domain of type IIb (or R2B) subfamily receptor-type tyrosine-protein phosphatases, repeat 2; The type IIb (or R2B) subfamily of receptor protein tyrosine phosphatases (RPTPs) include the prototypical member PTPmu (or PTPRM), PCP-2 (or PTPRU), PTPrho (or PTPRT), and PTPkappa (or PTPRK). They belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. Type IIb RPTPs mediate cell-cell adhesion though homophilic interactions; their ligand is an identical molecule on an adjacent cell. No heterophilic interactions between the subfamily members have been observed. They also commonly function as tumor suppressors. They contain an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the second (repeat 2) PTP domain.

Pssm-ID: 350404 [Multi-domain] Cd Length: 201 Bit Score: 40.47 E-value: 7.46e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWP-DRGVPDADLAPIVLLARLKE-----NTAPIIVHCSAGIGRTGSIVLIQHAMELLHLPApLLEISTYLIELR 75
Cdd:cd14556  105 QFQFLGWPrDRDTPPSKRALLKLLSEVEKwqeqsGEGPIVVHCLNGVGRSGVFCAISSVCERIKVEN-VVDVFQAVKTLR 183

                         90
                 ....*....|....*...
gi 597894931  76 KQRNNSIQTEHQYLYIHQ 93
Cdd:cd14556  184 NHRPNMVETEEQYKFCYD 201

DUSP23

cd14504

dual specificity phosphatase 23; Dual specificity phosphatase 23 (DUSP23), also known as ...

32-87

7.87e-05

dual specificity phosphatase 23; Dual specificity phosphatase 23 (DUSP23), also known as VH1-like phosphatase Z (VHZ) or low molecular mass dual specificity phosphatase 3 (LDP-3), functions as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). It deactivates its MAPK substrates by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. DUSP23 is an atypical DUSP; it contains the catalytic dual specificity phosphatase domain but lacks the N-terminal Cdc25/rhodanese-like domain that is present in typical DUSPs or MKPs. It is able to enhance activation of JNK and p38 MAPK, and has been shown to dephosphorylate p44-ERK1 (MAPK3) in vitro. It has been associated with cell growth and human primary cancers. It has also been identified as a cell-cell adhesion regulatory protein; it promotes the dephosphorylation of beta-catenin at Tyr 142 and enhances the interaction between alpha- and beta-catenin.

Pssm-ID: 350354 [Multi-domain] Cd Length: 142 Bit Score: 39.57 E-value: 7.87e-05

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 597894931  32 APIIVHCSAGIGRTGSIV---LIQHAmellHLPAplleiSTYLIELRKQRNNSIQTEHQ 87
Cdd:cd14504   83 EAVLVHCLAGKGRTGTMLacyLVKTG----KISA-----VDAINEIRRIRPGSIETSEQ 132

R-PTPc-T-2

cd14634

PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2; Receptor-type ...

2-96

1.47e-04

PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2; Receptor-type tyrosine-protein phosphatase T (PTPRT), also known as receptor-type tyrosine-protein phosphatase rho (RPTP-rho or PTPrho), belongs to the type IIb subfamily of receptor protein tyrosine phosphatases (RPTPs), which belong to the larger family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPRT is highly expressed in the nervous system and it plays a critical role in regulation of synaptic formation and neuronal development. It dephosphorylates a specific tyrosine residue in syntaxin-binding protein 1, a key component of synaptic vesicle fusion machinery, and regulates its binding to syntaxin 1. PTPRT has been identified as a potential candidate gene for autism spectrum disorder (ASD) susceptibility. It contains an extracellular region with an Meprin-A5 (neuropilin)-mu (MAM) domain, an immunoglobulin (Ig) domain, and four fibronectin type III (FN3) repeats, a transmembrane domain, and an intracellular segment with a juxtamembrane domain similar to the cytoplasmic domain of classical cadherins and two tandem PTP domains. This model represents the second (repeat 2) PTP domain.

Pssm-ID: 350482 [Multi-domain] Cd Length: 206 Bit Score: 39.62 E-value: 1.47e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   2 HYHWQDWPD-RGVPDADLAPIVLLARLKE-------NTAPIIVHCSAGIGRTGSIVLIQHAMELLHlPAPLLEISTYLIE 73
Cdd:cd14634  104 HLQYIGWPAyRDTPPSKRSILKVVRRLEKwqeqydgREGRTVVHCLNGGGRSGTFCAICSVCEMIQ-QQNIIDVFHTVKT 182

                         90       100
                 ....*....|....*....|...
gi 597894931  74 LRKQRNNSIQTEHQYLYIHQVLL 96
Cdd:cd14634  183 LRNNKSNMVETLEQYKFVYEVAL 205

TpbA-like

cd14529

bacterial protein tyrosine and dual-specificity phosphatases related to Pseudomonas aeruginosa ...

2-49

1.36e-03

bacterial protein tyrosine and dual-specificity phosphatases related to Pseudomonas aeruginosa TpbA; This subfamily contains bacterial protein tyrosine phosphatases (PTPs) and dual-specificity phosphatases (DUSPs) related to Pseudomonas aeruginosa TpbA, a DUSP that negatively regulates biofilm formation by converting extracellular quorum sensing signals and to Mycobacterium tuberculosis PtpB, a PTP virulence factor that attenuates host immune defenses by interfering with signal transduction pathways in macrophages. PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides, while DUSPs function as protein-serine/threonine phosphatases (EC 3.1.3.16) and PTPs.

Pssm-ID: 350378 [Multi-domain] Cd Length: 158 Bit Score: 36.58 E-value: 1.36e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 597894931   2 HYHWQDWPDRGVPDADLAPIVLLARLKENTAPIIVHCSAGIGRTGSIV 49
Cdd:cd14529   60 KYVNLPLSATRPTESDVQSFLLIMDLKLAPGPVLIHCKHGKDRTGLVS 107

PTP-IVa

cd14500

protein tyrosine phosphatase type IVA family; Protein tyrosine phosphatases type IVA (PTP-IVa), ...

7-89

4.82e-03

protein tyrosine phosphatase type IVA family; Protein tyrosine phosphatases type IVA (PTP-IVa), also known as protein-tyrosine phosphatases of regenerating liver (PRLs) constitute a family of small, prenylated phosphatases that are the most oncogenic of all PTPs. They stimulate progression from G1 into S phase during mitosis and enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. They associate with magnesium transporters of the cyclin M (CNNM) family, which results in increased intracellular magnesium levels that promote oncogenic transformation. Vertebrates contain three members: PRL-1, PRL-2, and PRL-3.

Pssm-ID: 350350 [Multi-domain] Cd Length: 156 Bit Score: 34.89 E-value: 4.82e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597894931   7 DWP--DRGVPDADlapIV------LLARLKENTAP---IIVHCSAGIGRTG---SIVLIQHAMEllhlpaplleistYL- 71
Cdd:cd14500   63 DWPfdDGSPPPDD---VVddwldlLKTRFKEEGKPgacIAVHCVAGLGRAPvlvAIALIELGMK-------------PEd 126

                         90       100
                 ....*....|....*....|.
gi 597894931  72 -IEL-RKQRNNSI-QTEHQYL 89
Cdd:cd14500  127 aVEFiRKKRRGAInSKQLQFL 147

Y_phosphatase3

pfam13350

Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 ...

23-54

7.54e-03

Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 families.

Pssm-ID: 463853 [Multi-domain] Cd Length: 243 Bit Score: 34.91 E-value: 7.54e-03

                          10        20        30
                  ....*....|....*....|....*....|...
gi 597894931   23 LLARLKENTAPIIVHCSAGIGRTG-SIVLIQHA 54
Cdd:pfam13350 121 LFEALADNDGPVLFHCTAGKDRTGvAAALLLSL 153

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01