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Conserved domains on  [gi|595614150|gb|AHM57794|]
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HTH-type transcriptional regulator MalT (plasmid) [Peptoclostridium acidaminophilum DSM 3953]

Protein Classification

MalT transcriptional regulator family protein( domain architecture ID 1001203)

MalT transcriptional regulator family protein similar to HTH-type transcriptional regulator MalT that positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides

Gene Ontology:  GO:0003700|GO:0003677|GO:0045893|GO:0005524
PubMed:  8809174|3015733

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04841 super family cl35271
HTH-type transcriptional regulator MalT;
8-869 3.12e-65

HTH-type transcriptional regulator MalT;


The actual alignment was detected with superfamily member PRK04841:

Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 235.61  E-value: 3.12e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150   8 KFMIPRTKSKMVERESLLSKLDNALGTKLTILWAPAGSGKTTAIVSWLESRNlegKTAWISLDERDDNPELFWSCFEYAA 87
Cdd:PRK04841   6 KLSRPVRLHNTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQWAAGKN---NLGWYSLDESDNQPERFASYLIAAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150  88 GKIMRDEP-------QPGNESSVEAFLNAI----SESDSELLLVMDDFHFIKNAEILRDIKHLIDDMGSNIHIIITSRTK 156
Cdd:PRK04841  83 QQATNGHCsksealaQKRQYASLSSLFAQLfielADWHQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTLVVLSRNL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 157 VNLSLARLRLSGEVTEIDRKDMAFDYRDAGEFLRSNTKLKISEKNVKLINDRTEGWAAGIQMAMLSLKEKKD-LAELEEK 235
Cdd:PRK04841 163 PPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRLSSPIEAAESSRLCDDVEGWATALQLIALSARQNNSsLHDSARR 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 236 FNGCS-GYVEDYFSEEIFNEQPEEIKDFLLKTCILDELVPGLCSAVSGRKDSQELLEHIYDSNLFVDKQDYDEKIFRYNT 314
Cdd:PRK04841 243 LAGINaSHLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMDDSGEWFRYHP 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 315 LFKEFLLCKSKGMNLDAVYEASNRAAKWYRESGVLNKAINQYIEVGNLEPVIDLVESECIRMVLCSEQSQVFHWLESIPQ 394
Cdd:PRK04841 323 LFASFLRHRCQWELAQELPELHRAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLQHGWSLFNQGELSLLEECLNALPW 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 395 DIILKKPRLCIANMFihicddISYSKYR-----------EFAIKTLESYEDEDFRGECQRL---MTIAEGDRHfikseyk 460
Cdd:PRK04841 403 EVLLENPRLVLLQAW------LAQSQHRysevntllaraEQELKDRNIELDGTLQAEFNALraqVAINDGDPE------- 469

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 461 KSIGLYEKA-QAIPGNTALYDIAINLKLGVAHFYMHDLegekiyfDKALLLSQ----------SY---------QDEIM- 519
Cdd:PRK04841 470 EAERLAELAlAELPLTWYYSRIVATSVLGEVHHCKGEL-------ARALAMMQqteqmarqhdVYhyalwsllqQSEILf 542

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 520 ---YLVVCRTTVFTKFlrrELVECESicgvcinsrmndaLRKSSFMSIFYIILALVYYERNNIGKAEEYVSTGIELIERE 596
Cdd:PRK04841 543 aqgFLQAAYETQEKAF---QLIEEQH-------------LEQLPMHEFLLRIRAQLLWEWARLDEAEQCARKGLEVLSNY 606

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 597 GkPMQH--CYTLytglyvYAGILLDKNNKAELEKVCTKIEELSKGIEYER-------IPDLYY---LNKLESYFDLFKIE 664
Cdd:PRK04841 607 Q-PQQQlqCLAM------LAKISLARGDLDNARRYLNRLENLLGNGRYHSdwianadKVRLIYwqmTGDKEAAANWLRQA 679

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 665 I--------FMEAGKANIVEKYISkldykipqelvmfsktlidKGKSDDALMLLNKIliseNKENQYLRL-----KAHIY 731
Cdd:PRK04841 680 PkpefannhFLQGQWRNIARAQIL-------------------LGQFDEAEIILEEL----NENARSLRLmsdlnRNLIL 736

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 732 RAEIFSQEDQYENATKDLREALTIGYENGFIRIFMFKS---IKTSRMLI--KTIGSMkfnkDYYKMSEYLNNIAAQY-SK 805
Cdd:PRK04841 737 LNQLYWQQGRKSEAQRVLLEALKLANRTGFISHFVIEGeamAQQLRQLIqlNTLPEL----EQHRAQRILREINQHHrHK 812

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 806 ----DKDF-----------EIV-----SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAK 865
Cdd:PRK04841 813 fahfDEAFvekllnhpdvpELIrtsplTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQH 892


                 ....
gi 595614150 866 AKEL 869
Cdd:PRK04841 893 AQDL 896
 
Name Accession Description Interval E-value
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
8-869 3.12e-65

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 235.61  E-value: 3.12e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150   8 KFMIPRTKSKMVERESLLSKLDNALGTKLTILWAPAGSGKTTAIVSWLESRNlegKTAWISLDERDDNPELFWSCFEYAA 87
Cdd:PRK04841   6 KLSRPVRLHNTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQWAAGKN---NLGWYSLDESDNQPERFASYLIAAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150  88 GKIMRDEP-------QPGNESSVEAFLNAI----SESDSELLLVMDDFHFIKNAEILRDIKHLIDDMGSNIHIIITSRTK 156
Cdd:PRK04841  83 QQATNGHCsksealaQKRQYASLSSLFAQLfielADWHQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTLVVLSRNL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 157 VNLSLARLRLSGEVTEIDRKDMAFDYRDAGEFLRSNTKLKISEKNVKLINDRTEGWAAGIQMAMLSLKEKKD-LAELEEK 235
Cdd:PRK04841 163 PPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRLSSPIEAAESSRLCDDVEGWATALQLIALSARQNNSsLHDSARR 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 236 FNGCS-GYVEDYFSEEIFNEQPEEIKDFLLKTCILDELVPGLCSAVSGRKDSQELLEHIYDSNLFVDKQDYDEKIFRYNT 314
Cdd:PRK04841 243 LAGINaSHLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMDDSGEWFRYHP 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 315 LFKEFLLCKSKGMNLDAVYEASNRAAKWYRESGVLNKAINQYIEVGNLEPVIDLVESECIRMVLCSEQSQVFHWLESIPQ 394
Cdd:PRK04841 323 LFASFLRHRCQWELAQELPELHRAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLQHGWSLFNQGELSLLEECLNALPW 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 395 DIILKKPRLCIANMFihicddISYSKYR-----------EFAIKTLESYEDEDFRGECQRL---MTIAEGDRHfikseyk 460
Cdd:PRK04841 403 EVLLENPRLVLLQAW------LAQSQHRysevntllaraEQELKDRNIELDGTLQAEFNALraqVAINDGDPE------- 469

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 461 KSIGLYEKA-QAIPGNTALYDIAINLKLGVAHFYMHDLegekiyfDKALLLSQ----------SY---------QDEIM- 519
Cdd:PRK04841 470 EAERLAELAlAELPLTWYYSRIVATSVLGEVHHCKGEL-------ARALAMMQqteqmarqhdVYhyalwsllqQSEILf 542

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 520 ---YLVVCRTTVFTKFlrrELVECESicgvcinsrmndaLRKSSFMSIFYIILALVYYERNNIGKAEEYVSTGIELIERE 596
Cdd:PRK04841 543 aqgFLQAAYETQEKAF---QLIEEQH-------------LEQLPMHEFLLRIRAQLLWEWARLDEAEQCARKGLEVLSNY 606

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 597 GkPMQH--CYTLytglyvYAGILLDKNNKAELEKVCTKIEELSKGIEYER-------IPDLYY---LNKLESYFDLFKIE 664
Cdd:PRK04841 607 Q-PQQQlqCLAM------LAKISLARGDLDNARRYLNRLENLLGNGRYHSdwianadKVRLIYwqmTGDKEAAANWLRQA 679

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 665 I--------FMEAGKANIVEKYISkldykipqelvmfsktlidKGKSDDALMLLNKIliseNKENQYLRL-----KAHIY 731
Cdd:PRK04841 680 PkpefannhFLQGQWRNIARAQIL-------------------LGQFDEAEIILEEL----NENARSLRLmsdlnRNLIL 736

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 732 RAEIFSQEDQYENATKDLREALTIGYENGFIRIFMFKS---IKTSRMLI--KTIGSMkfnkDYYKMSEYLNNIAAQY-SK 805
Cdd:PRK04841 737 LNQLYWQQGRKSEAQRVLLEALKLANRTGFISHFVIEGeamAQQLRQLIqlNTLPEL----EQHRAQRILREINQHHrHK 812

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 806 ----DKDF-----------EIV-----SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAK 865
Cdd:PRK04841 813 fahfDEAFvekllnhpdvpELIrtsplTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQH 892


                 ....
gi 595614150 866 AKEL 869
Cdd:PRK04841 893 AQDL 896
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 810-872 4.25e-22

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 92.65  E-value: 4.25e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595614150 810 EIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELGIL 872
Cdd:COG2197   68 RLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLL 130
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 813-866 2.39e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.19  E-value: 2.39e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 595614150   813 SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKA 866
Cdd:smart00421   5 TPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 813-868 6.41e-16

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 72.57  E-value: 6.41e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 595614150 813 SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKE 868
Cdd:cd06170    2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
810-866 5.78e-15

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 69.92  E-value: 5.78e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 595614150  810 EIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKA 866
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
 
Name Accession Description Interval E-value
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
8-869 3.12e-65

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 235.61  E-value: 3.12e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150   8 KFMIPRTKSKMVERESLLSKLDNALGTKLTILWAPAGSGKTTAIVSWLESRNlegKTAWISLDERDDNPELFWSCFEYAA 87
Cdd:PRK04841   6 KLSRPVRLHNTVVRERLLAKLSGANNYRLVLVTSPAGYGKTTLISQWAAGKN---NLGWYSLDESDNQPERFASYLIAAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150  88 GKIMRDEP-------QPGNESSVEAFLNAI----SESDSELLLVMDDFHFIKNAEILRDIKHLIDDMGSNIHIIITSRTK 156
Cdd:PRK04841  83 QQATNGHCsksealaQKRQYASLSSLFAQLfielADWHQPLYLVIDDYHLITNPEIHEAMRFFLRHQPENLTLVVLSRNL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 157 VNLSLARLRLSGEVTEIDRKDMAFDYRDAGEFLRSNTKLKISEKNVKLINDRTEGWAAGIQMAMLSLKEKKD-LAELEEK 235
Cdd:PRK04841 163 PPLGIANLRVRDQLLEIGSQQLAFDHQEAQQFFDQRLSSPIEAAESSRLCDDVEGWATALQLIALSARQNNSsLHDSARR 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 236 FNGCS-GYVEDYFSEEIFNEQPEEIKDFLLKTCILDELVPGLCSAVSGRKDSQELLEHIYDSNLFVDKQDYDEKIFRYNT 314
Cdd:PRK04841 243 LAGINaSHLSDYLVEEVLDNVDLETRHFLLRCSVLRSMNDALIVRVTGEENGQMRLEELERQGLFIQRMDDSGEWFRYHP 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 315 LFKEFLLCKSKGMNLDAVYEASNRAAKWYRESGVLNKAINQYIEVGNLEPVIDLVESECIRMVLCSEQSQVFHWLESIPQ 394
Cdd:PRK04841 323 LFASFLRHRCQWELAQELPELHRAAAEAWLAQGFPSEAIHHALAAGDAQLLRDILLQHGWSLFNQGELSLLEECLNALPW 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 395 DIILKKPRLCIANMFihicddISYSKYR-----------EFAIKTLESYEDEDFRGECQRL---MTIAEGDRHfikseyk 460
Cdd:PRK04841 403 EVLLENPRLVLLQAW------LAQSQHRysevntllaraEQELKDRNIELDGTLQAEFNALraqVAINDGDPE------- 469

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 461 KSIGLYEKA-QAIPGNTALYDIAINLKLGVAHFYMHDLegekiyfDKALLLSQ----------SY---------QDEIM- 519
Cdd:PRK04841 470 EAERLAELAlAELPLTWYYSRIVATSVLGEVHHCKGEL-------ARALAMMQqteqmarqhdVYhyalwsllqQSEILf 542

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 520 ---YLVVCRTTVFTKFlrrELVECESicgvcinsrmndaLRKSSFMSIFYIILALVYYERNNIGKAEEYVSTGIELIERE 596
Cdd:PRK04841 543 aqgFLQAAYETQEKAF---QLIEEQH-------------LEQLPMHEFLLRIRAQLLWEWARLDEAEQCARKGLEVLSNY 606

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 597 GkPMQH--CYTLytglyvYAGILLDKNNKAELEKVCTKIEELSKGIEYER-------IPDLYY---LNKLESYFDLFKIE 664
Cdd:PRK04841 607 Q-PQQQlqCLAM------LAKISLARGDLDNARRYLNRLENLLGNGRYHSdwianadKVRLIYwqmTGDKEAAANWLRQA 679

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 665 I--------FMEAGKANIVEKYISkldykipqelvmfsktlidKGKSDDALMLLNKIliseNKENQYLRL-----KAHIY 731
Cdd:PRK04841 680 PkpefannhFLQGQWRNIARAQIL-------------------LGQFDEAEIILEEL----NENARSLRLmsdlnRNLIL 736

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 732 RAEIFSQEDQYENATKDLREALTIGYENGFIRIFMFKS---IKTSRMLI--KTIGSMkfnkDYYKMSEYLNNIAAQY-SK 805
Cdd:PRK04841 737 LNQLYWQQGRKSEAQRVLLEALKLANRTGFISHFVIEGeamAQQLRQLIqlNTLPEL----EQHRAQRILREINQHHrHK 812

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 806 ----DKDF-----------EIV-----SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAK 865
Cdd:PRK04841 813 fahfDEAFvekllnhpdvpELIrtsplTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQH 892


                 ....
gi 595614150 866 AKEL 869
Cdd:PRK04841 893 AQDL 896
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 810-872 4.25e-22

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 92.65  E-value: 4.25e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595614150 810 EIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELGIL 872
Cdd:COG2197   68 RLLTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLL 130
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 810-872 5.31e-22

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 90.40  E-value: 5.31e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595614150 810 EIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELGIL 872
Cdd:COG5905   11 SLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 813-866 2.39e-19

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.19  E-value: 2.39e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 595614150   813 SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKA 866
Cdd:smart00421   5 TPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
813-872 4.07e-17

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 80.18  E-value: 4.07e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 813 SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELGIL 872
Cdd:COG2771  129 TPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGLI 188
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
822-872 3.35e-16

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 77.44  E-value: 3.35e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 595614150 822 LIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELGIL 872
Cdd:COG2909  133 LLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLL 183
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 813-868 6.41e-16

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 72.57  E-value: 6.41e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 595614150 813 SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKE 868
Cdd:cd06170    2 TPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
810-866 5.78e-15

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 69.92  E-value: 5.78e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 595614150  810 EIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKA 866
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
118-213 1.88e-13

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 69.73  E-value: 1.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 118 LLVMDDFHFIKNAEILRdikhLIDDMGSNIHIIITSRTkvnLSLARLRLSgevTEIDRKDMAFDyrDAGEFLRSNTkLKI 197
Cdd:COG2909    1 ALVLDDYHLIDDIHLAF----LLRHLPPNLHLVLASRT---DPLARLRAR---LELRADDLRRE--EAAALLRRRL-LPL 67

                         90
                 ....*....|....*.
gi 595614150 198 SEKNVKLINDRTEGWA 213
Cdd:COG2909   68 SEEDAARLAERTEGWA 83
PRK10100 PRK10100
transcriptional regulator CsgD;
791-868 6.45e-13

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 68.74  E-value: 6.45e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 595614150 791 KMSEYLNNIAAQYSKDK-DFEIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKE 868
Cdd:PRK10100 134 KLASYLITHSGNYRYNStESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWAND 212
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 792-862 4.55e-11

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 63.51  E-value: 4.55e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 595614150 792 MSEYLNNIAAQ------YSKDKDFEIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQA 862
Cdd:PRK10651 130 LSEALTPVLAAslranrATTERDVNQLTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEA 206
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 813-870 1.68e-09

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 58.19  E-value: 1.68e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 595614150 813 SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELG 870
Cdd:COG4566  139 TPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAELVRLALALG 196
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
791-862 1.68e-09

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 58.71  E-value: 1.68e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 595614150 791 KMSEYLNNIAAQYSKDKDFEIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQA 862
Cdd:PRK10403 133 RVNQYLREREMFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAA 204
TPR_MalT pfam17874
MalT-like TPR region; This entry contains a series of TPR repeats.
 566-765 2.21e-09

MalT-like TPR region; This entry contains a series of TPR repeats.


Pssm-ID: 436107 [Multi-domain]  Cd Length: 336  Bit Score: 60.02  E-value: 2.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150  566 YIILALVYYERNNIGKAEEYVSTGIELIeREGKPMQ--HCYTLYtglyvyAGILLDKNNKAELEKVCTKIEELSKG---- 639
Cdd:pfam17874 125 LVGLADLLYEWNDLEEAEQHAQQGIQLG-RQWEPDAavDAYVLL------ARIALAQGELEEALTLLRRAELLARQsffh 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150  640 ----IEYERIPDLYYLNKlesyFDLFKIEIFMEAgkaniVEKYISKLDYKIPQELVMFSKTLIDKGKSDDALMLLNKILI 715
Cdd:pfam17874 198 vdwlANAERVRVRLWLAR----GDLRAAVRWLRA-----AEPPSDADNHFLERELRNLARVLLALGRFDDALSLLERLQN 268

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 595614150  716 -SENKENQYLRLKAHIYRAEIFSQEDQYENATKDLREALTIGYENGFIRIF 765
Cdd:pfam17874 269 lAEQLGRVRSLIENLILQALALLALGRPDEALQALLDALSLAEPEGYVRSF 319
PRK15369 PRK15369
two component system response regulator;
806-872 7.81e-07

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 50.85  E-value: 7.81e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 595614150 806 DKDFEIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELGIL 872
Cdd:PRK15369 144 DTNPPLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
812-869 9.16e-05

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 44.48  E-value: 9.16e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 812 VSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAV--AKAKEL 869
Cdd:PRK09935 150 LSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIdyAKLHEL 209
PRK09483 PRK09483
response regulator; Provisional
 801-861 1.52e-04

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 43.94  E-value: 1.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 595614150 801 AQYSKDKD--FEIVSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQ 861
Cdd:PRK09483 136 SQIEPATEnpFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVE 198
AAA_22 pfam13401
AAA domain;
36-151 4.71e-04

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 40.79  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150   36 LTILWAPAGSGKTTAI---VSWLESRNLEgkTAWISLDERDDNPELFWS-CFEYAAGKIMRDEPQPGnessVEAFLNAIS 111
Cdd:pfam13401   7 ILVLTGESGTGKTTLLrrlLEQLPEVRDS--VVFVDLPSGTSPKDLLRAlLRALGLPLSGRLSKEEL----LAALQQLLL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 595614150  112 ESDSELLLVMDDFHFIKnAEILRDIKHLIDDMGSNIHIII 151
Cdd:pfam13401  81 ALAVAVVLIIDEAQHLS-LEALEELRDLLNLSSKLLQLIL 119
PRK10360 PRK10360
transcriptional regulator UhpA;
812-861 2.60e-03

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 39.96  E-value: 2.60e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 595614150 812 VSKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQ 861
Cdd:PRK10360 138 LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVE 187
PRK10188 PRK10188
transcriptional regulator SdiA;
813-872 5.65e-03

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 39.38  E-value: 5.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150 813 SKREKEVLMLIEKGAKNSEIAKELFITESTAKSHILNIFSKLGVRNRVQAVAKAKELGIL 872
Cdd:PRK10188 181 SKREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNKTQIACYAAATGLI 240
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
18-155 7.65e-03

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 40.17  E-value: 7.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150  18 MVERESLLSKLD--NALGTKLTILwAPAGSGKTT-----AIVSWLESRNLEGKTA-WISLDERDDNPELFwscfEYAAGK 89
Cdd:COG5635  163 LLERIESLKRLEllEAKKKRLLIL-GEPGSGKTTllrylALELAERYLDAEDPIPiLIELRDLAEEASLE----DLLAEA 237

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595614150  90 IMRDEPQPGNEssVEAFLNaisesDSELLLVMDDF----HFIKNAEILRDIKHLIDDmGSNIHIIITSRT 155
Cdd:COG5635  238 LEKRGGEPEDA--LERLLR-----NGRLLLLLDGLdevpDEADRDEVLNQLRRFLER-YPKARVIITSRP 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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