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Conserved domains on  [gi|5901910|ref|NP_008984|]
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CD160 antigen precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgC2_CD160 cd21392
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ...
 26-144 2.02e-78

Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.


:

Pssm-ID: 409621  Cd Length: 119  Bit Score: 229.22  E-value: 2.02e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5901910   26 CINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPL 105
Cdd:cd21392   1 CYHISSSASQEGGRLNLTCTVWHKKEEAEGLIVFWCKDRSNDCSPETSLKQLRLKRDPESDGVTERSSQLVFTINQVTPS 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 5901910  106 HSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLK 144
Cdd:cd21392  81 DSGTYQCCARSQKPEIHLQGHFISVLVTETGNYTVTGLK 119
 
Name Accession Description Interval E-value
IgC2_CD160 cd21392
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ...
 26-144 2.02e-78

Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.


Pssm-ID: 409621  Cd Length: 119  Bit Score: 229.22  E-value: 2.02e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5901910   26 CINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPL 105
Cdd:cd21392   1 CYHISSSASQEGGRLNLTCTVWHKKEEAEGLIVFWCKDRSNDCSPETSLKQLRLKRDPESDGVTERSSQLVFTINQVTPS 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 5901910  106 HSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLK 144
Cdd:cd21392  81 DSGTYQCCARSQKPEIHLQGHFISVLVTETGNYTVTGLK 119
 
Name Accession Description Interval E-value
IgC2_CD160 cd21392
Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed ...
 26-144 2.02e-78

Immunoglobulin Constant-2 domain of Cluster of Differentiation 160 (CD160); CD160 is expressed at the cell surface as a tightly disulfide-linked multimer and is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. Structurally similar to The B and T lymphocyte attenuator (BTLA), which appears to act as a negative regulator of T cell activation and growth. CD160 is a ligand for HVEM (herpes virus entry mediator), and considered a proposed immune checkpoint inhibitor with anti-cancer activity along with anti-PD-1 antibodies. CD160 has also been proposed as a potential target in cases of human pathological ocular and tumor neoangiogenesis that do not respond or become resistant to existing antiangiogenic drugs.


Pssm-ID: 409621  Cd Length: 119  Bit Score: 229.22  E-value: 2.02e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5901910   26 CINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPL 105
Cdd:cd21392   1 CYHISSSASQEGGRLNLTCTVWHKKEEAEGLIVFWCKDRSNDCSPETSLKQLRLKRDPESDGVTERSSQLVFTINQVTPS 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 5901910  106 HSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLK 144
Cdd:cd21392  81 DSGTYQCCARSQKPEIHLQGHFISVLVTETGNYTVTGLK 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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