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Conserved domains on  [gi|589144436|ref|YP_009003725|]
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NADH dehydrogenase subunit 4L (mitochondrion) [Vieja melanura]

Protein Classification

NADH-ubiquinone oxidoreductase subunit 4L( domain architecture ID 10009576)

NADH-ubiquinone oxidoreductase subunit 4L (ND4L) is core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.66e-50

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177185  Cd Length: 98  Bit Score: 154.35  E-value: 1.66e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 589144436 81 STRTHGTDRLQSLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.66e-50

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 154.35  E-value: 1.66e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 589144436 81 STRTHGTDRLQSLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.88e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 65.28  E-value: 1.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436   3 PAHFTFSSMFMLGLAGLAFHRtHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVAST 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 589144436  83 RTHGTDRLQSLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-96 9.95e-06

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 40.43  E-value: 9.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSS--MFMLGLAGLAFHRtHLLSALLCLEGMMLS---LFIALSLWTLQLNSTSFSaspMLLLAFSACEASAGL 75
Cdd:COG0713   1 IPLEHYLILAaiLFAIGLYGVLTRR-NLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGL 76

                        90       100
                ....*....|....*....|.
gi 589144436 76 ALLVASTRTHGTDRLQSLNLL 96
Cdd:COG0713  77 AIIVALYRNRGTIDVDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.66e-50

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 154.35  E-value: 1.66e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 589144436 81 STRTHGTDRLQSLNLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 6.81e-38

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 122.40  E-value: 6.81e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 589144436 81 STRTHGTDRLQSLNLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.56e-35

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 116.48  E-value: 1.56e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 589144436 81 STRTHGTDRLQSLNLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.47e-24

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 88.45  E-value: 1.47e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 589144436 81 STRTHGTDRLQSLNLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 5-96 2.50e-20

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 77.68  E-value: 2.50e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  5 HFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVASTRT 84
Cdd:MTH00181  2 MFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRT 81

                        90
                ....*....|..
gi 589144436 85 HGTDRLQSLNLL 96
Cdd:MTH00181 82 HGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.57e-19

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 75.73  E-value: 1.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 589144436 81 STRTHGTDRLQSLNLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 1.88e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 65.28  E-value: 1.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436   3 PAHFTFSSMFMLGLAGLAFHRtHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVAST 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLLLRR-NLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 589144436  83 RTHGTDRLQSLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 6-98 1.06e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 58.45  E-value: 1.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  6 FTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSAspMLLLAFSACEASAGLALLVASTRTH 85
Cdd:MTH00188  7 LVILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELYLS--LVLLTFAACEASVGLALLVSLIRSH 84

                        90
                ....*....|...
gi 589144436 86 GTDRLQSLNLLQC 98
Cdd:MTH00188 85 GSDYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.22e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 50.61  E-value: 1.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIalSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVA 80
Cdd:MTH00149  2 MFMLLLLSLFGFLMGVFALLFQYKHLLSILLSLEALMLSLLV--MMFSSSGLISFSSYLFLIILTFGACEASLGLSLLVS 79

                        90
                ....*....|....*...
gi 589144436 81 STRTHGTDRLQSLNLLQC 98
Cdd:MTH00149 80 LIRLHGNDYVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 6-92 2.14e-09

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 49.77  E-value: 2.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  6 FTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFsaSPMLLLAFSACEASAGLALLVASTRTH 85
Cdd:MTH00162  5 LIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELY--FLLFFLTFSVCEGALGLSILVSMIRSH 82


                ....*..
gi 589144436 86 GTDRLQS 92
Cdd:MTH00162 83 GNDYFSS 89
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 11-97 6.49e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 46.18  E-value: 6.49e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436 11 MFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVASTRTHGTDRL 90
Cdd:MTH00180 12 LFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTIAV 91


                ....*..
gi 589144436 91 QSLNLLQ 97
Cdd:MTH00180 92 KSLNLLR 98
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 3.29e-07

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 44.36  E-value: 3.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSSMFMLGLAGLAFHRTHLLSALLCLEGMMLSL--FIALSLWTLQLNSTSFSaspMLLLAFSACEASAGLALL 78
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLalFIPLSLMFANQVNGMLA---IVLLTFGACEASLGLSLL 77

                        90       100
                ....*....|....*....|
gi 589144436 79 VASTRTHGTDRLQSLNLLQC 98
Cdd:MTH00013 78 VLMTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 1-96 9.95e-06

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 40.43  E-value: 9.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436  1 MTPAHFTFSS--MFMLGLAGLAFHRtHLLSALLCLEGMMLS---LFIALSLWTLQLNSTSFSaspMLLLAFSACEASAGL 75
Cdd:COG0713   1 IPLEHYLILAaiLFAIGLYGVLTRR-NLIVVLMSIELMLNAvnlNLVAFSRYLGDLDGQVFA---LFVIAVAAAEVAVGL 76

                        90       100
                ....*....|....*....|.
gi 589144436 76 ALLVASTRTHGTDRLQSLNLL 96
Cdd:COG0713  77 AIIVALYRNRGTIDVDDLNEL 97
ND4L MTH00001
NADH dehydrogenase subunit 4L; Provisional
 11-97 1.15e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177099  Cd Length: 99  Bit Score: 40.43  E-value: 1.15e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436 11 MFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVASTRTHGTDRL 90
Cdd:MTH00001 12 LFLLGIWGIILNRGHFIIMLVSIELVLLSTFFLFLINSIEIDLLIEQIFTIMGLTIAAAESAIGLAIMVAYYRIRGTISL 91


                ....*..
gi 589144436 91 QSLNLLQ 97
Cdd:MTH00001 92 KSLNSLR 98
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
1-96 2.12e-05

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 39.39  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436   1 MTPAHFTFSS--MFMLGLAGLaFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALL 78
Cdd:PRK05715   2 IPLQHYLILAaiLFCIGLVGL-LLRRNAIVVLMSIELMLNAVNLNFVAFSSYLGDLDGQVFAFFVITVAAAEAAIGLAIL 80

                         90
                 ....*....|....*...
gi 589144436  79 VASTRTHGTDRLQSLNLL 96
Cdd:PRK05715  81 LQLYRNRGTIDVDDLNEL 98
ND4 MTH00127
NADH dehydrogenase subunit 4; Provisional
 31-98 5.60e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 177186 [Multi-domain]  Cd Length: 459  Bit Score: 34.55  E-value: 5.60e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 589144436  31 LCLEGMMLSLFIALSLWTLQLNSTSfsaspmlllafSACEASAGLALLVASTRTHGTDRLQSLNLLQC 98
Cdd:MTH00127 376 LMGELMIITSLFNWSPWTLALTGLG-----------TLITAGYSLYMFLMTQRGPLPDHIIALNPSHT 432
ND4L MTH00192
NADH dehydrogenase subunit 4L; Provisional
 11-97 9.68e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177240  Cd Length: 99  Bit Score: 32.59  E-value: 9.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589144436 11 MFMLGLAGLAFHRTHLLSALLCLEGMMLSLFIALSLWTLQLNSTSFSASPMLLLAFSACEASAGLALLVASTRTHGTDRL 90
Cdd:MTH00192 12 LFTTGVSGIIINKNNIILILMSIELILLAISYLLIVYSVTLDNLLGIIFSLMVLTVAAAESAIGLAILVAYFRLTGTITI 91


                ....*..
gi 589144436 91 QSLNLLQ 97
Cdd:MTH00192 92 KALNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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