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Conserved domains on  [gi|58801252|dbj|BAA32466|]
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MEGF5, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1224-1350 1.41e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   1224 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1301
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 58801252   1302 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1350
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-253 1.09e-27

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.73  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   98 NAERLDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 177
Cdd:COG4886  114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLS 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252  178 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 253
Cdd:COG4886  191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
624-936 1.38e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  624 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 703
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  704 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 783
Cdd:COG4886  144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  784 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 860
Cdd:COG4886  176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252  861 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 936
Cdd:COG4886  252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
362-702 1.74e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 1.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  362 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 441
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  442 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 521
Cdd:COG4886  162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  522 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 599
Cdd:COG4886  208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  600 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITT 679
Cdd:COG4886  257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                        330       340
                 ....*....|....*....|...
gi 58801252  680 ITPGAFTTLVSLSTINLLSNPFN 702
Cdd:COG4886  335 VTLTTLALSLSLLALLTLLLLLN 357
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1110-1146 1.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 58801252 1110 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1146
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1034-1067 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.92e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 58801252 1034 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 1067
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 992-1030 3.37e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.37e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 58801252  992 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 1030
Cdd:cd00054    2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1159-1189 3.66e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.66e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 58801252   1159 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1189
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1071-1108 4.10e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.10e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 58801252 1071 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1108
Cdd:cd00054    2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
69-100 7.90e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.90e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 58801252      69 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 100
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 224-286 1.13e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 1.13e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252    224 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 286
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1502-1557 3.38e-04

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 40.85  E-value: 3.38e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252    1502 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1557
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
LRRNT smart00013
Leucine rich repeat N-terminal domain;
316-347 1.43e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 58801252     316 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 347
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1408-1436 3.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 58801252   1408 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1436
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1224-1350 1.41e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   1224 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1301
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 58801252   1302 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1350
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1217-1350 3.70e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.70e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    1217 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 1293
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801252    1294 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 1350
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1195-1348 3.87e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 3.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252 1195 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1270
Cdd:cd00110    1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58801252 1271 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 1348
Cdd:cd00110   79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-253 1.09e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.73  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   98 NAERLDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 177
Cdd:COG4886  114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLS 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252  178 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 253
Cdd:COG4886  191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
624-936 1.38e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  624 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 703
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  704 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 783
Cdd:COG4886  144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  784 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 860
Cdd:COG4886  176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252  861 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 936
Cdd:COG4886  252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
362-702 1.74e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 1.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  362 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 441
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  442 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 521
Cdd:COG4886  162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  522 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 599
Cdd:COG4886  208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  600 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITT 679
Cdd:COG4886  257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                        330       340
                 ....*....|....*....|...
gi 58801252  680 ITPGAFTTLVSLSTINLLSNPFN 702
Cdd:COG4886  335 VTLTTLALSLSLLALLTLLLLLN 357
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-253 1.09e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   97 RNAERLDLDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQS------TPK 170
Cdd:cd21340   46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPrslaalSNS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  171 LTRLDLSenqiqgiprkafrgitdvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRL 248
Cdd:cd21340  122 LRVLNIS------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDL 175


                 ....*
gi 58801252  249 HSNHL 253
Cdd:cd21340  176 TGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
811-871 1.17e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 1.17e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252    811 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 871
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
593-653 7.05e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 7.05e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252    593 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI 653
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
195-253 3.97e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 3.97e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252    195 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 253
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 672-750 2.57e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 2.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    672 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 748
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 58801252    749 GN 750
Cdd:TIGR00864   82 EE 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 770-896 1.49e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 1.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  770 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 848
Cdd:cd21340    5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  849 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 895
Cdd:cd21340   82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                 .
gi 58801252  896 H 896
Cdd:cd21340  155 S 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
558-826 3.50e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   558 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 632
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   633 HGRVfrgLSGLKTLMLRSNLIGCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 712
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   713 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 792
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 58801252   793 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 826
Cdd:PRK15370  372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1110-1146 1.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 58801252 1110 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1146
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
893-942 4.06e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 4.06e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 58801252     893 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 942
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
291-572 1.15e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   291 DVQKKEYVCPAPHSEPPScNANSISCPSPCTCSNNIVDCRGK-GLMEIPANLPEGIVEIRLEQNSIKAIPAGAftqYKKL 369
Cdd:PRK15370  147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   370 KRIDISKNQISDIA---PDAFQGLKsltslvLYGNKITEIAKGLfdgLVSLQLLLLNANKINCLRVNTFQDLQNlnlLSL 446
Cdd:PRK15370  223 KTLYANSNQLTSIPatlPDTIQEME------LSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRY---LSV 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   447 YDNKLQTISKGLfaPlQSIQTLHLAQN-----PFVCDCHLKWL-ADylqDNPIETSGArcSSPRRLANKRISQ----IKS 516
Cdd:PRK15370  291 YDNSIRTLPAHL--P-SGITHLNVQSNsltalPETLPPGLKTLeAG---ENALTSLPA--SLPPELQVLDVSKnqitVLP 362

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252   517 KKFRCSGSEDYRSRfssECFMDLvcPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD 572
Cdd:PRK15370  363 ETLPPTITTLDVSR---NALTNL--PENLPAALQIMQASRNNLVRLPESLPHFRGE 413
EGF_CA smart00179
Calcium-binding EGF-like domain;
1110-1146 2.61e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.61e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 58801252    1110 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 1146
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
88-253 2.83e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    88 LRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHledNQVSVIERGAFQDLKQLERLRlnkNKLQVLPELLFQS 167
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFH---NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   168 tpkLTRLDLSENQIQGIPRKAFRGItdvKNLQLDNNHISCIEDGAFRALRDLEIltlNNNnisRILVTSFNHMPKIRTLR 247
Cdd:PRK15370  306 ---ITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSLPASLPPELQVLDV---SKN---QITVLPETLPPTITTLD 373


                  ....*.
gi 58801252   248 LHSNHL 253
Cdd:PRK15370  374 VSRNAL 379
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1034-1067 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.92e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 58801252 1034 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 1067
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 446-509 2.41e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.41e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58801252    446 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 509
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1036-1065 3.29e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.29e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 58801252   1036 CEDNDCENNATCVDGINNYVCICPPNYTGE 1065
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 992-1030 3.37e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.37e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 58801252  992 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 1030
Cdd:cd00054    2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1159-1189 3.66e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.66e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 58801252   1159 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1189
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1114-1144 4.00e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 4.00e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 58801252   1114 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1144
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1071-1108 4.10e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.10e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 58801252 1071 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1108
Cdd:cd00054    2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRNT smart00013
Leucine rich repeat N-terminal domain;
69-100 7.90e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.90e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 58801252      69 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 100
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 69-96 8.10e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 8.10e-05
                           10        20
                   ....*....|....*....|....*...
gi 58801252     69 ACPTKCTCSAASVDCHGLGLRAVPRGIP 96
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 224-286 1.13e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 1.13e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252    224 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 286
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
EGF_CA smart00179
Calcium-binding EGF-like domain;
1034-1063 1.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.80e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 58801252    1034 DDCE-DNDCENNATCVDGINNYVCICPPNYT 1063
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1502-1557 3.38e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.85  E-value: 3.38e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252    1502 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1557
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-410 3.43e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    97 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSvieRGAFQDL-KQ--LERLRLNKNKLQ-VLPELLFQSTpKLT 172
Cdd:PLN00113  308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS---GEIPKNLgKHnnLTVLDLSTNNLTgEIPEGLCSSG-NLF 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   173 RLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNH 252
Cdd:PLN00113  384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   253 LYCDchlawLSDWLRQRRtvgqftlcmapvhLRGFNVADvqkkeyvcpaphseppscnaNSISCPSPctcsnnivdcrgK 332
Cdd:PLN00113  464 FFGG-----LPDSFGSKR-------------LENLDLSR--------------------NQFSGAVP------------R 493

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252   333 GLMeipaNLPEgIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-EIAKGL 410
Cdd:PLN00113  494 KLG----SLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
LRRCT smart00082
Leucine rich repeat C-terminal domain;
473-503 6.62e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 6.62e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 58801252     473 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 503
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1108 7.06e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.06e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 58801252    1071 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 1108
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
316-347 1.43e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 58801252     316 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 347
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 316-342 1.73e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.73e-03
                           10        20
                   ....*....|....*....|....*..
gi 58801252    316 CPSPCTCSNNIVDCRGKGLMEIPANLP 342
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1408-1436 3.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 58801252   1408 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1436
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 995-1028 3.71e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 58801252    995 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 1028
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1030 4.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.86e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 58801252     998 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 1030
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
LRR smart00370
Leucine-rich repeats, outliers;
169-191 6.39e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.39e-03
                            10        20
                    ....*....|....*....|...
gi 58801252     169 PKLTRLDLSENQIQGIPRKAFRG 191
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1224-1350 1.41e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   1224 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1301
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 58801252   1302 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1350
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1217-1350 3.70e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.70e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    1217 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 1293
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801252    1294 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 1350
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1195-1348 3.87e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 3.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252 1195 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1270
Cdd:cd00110    1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58801252 1271 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 1348
Cdd:cd00110   79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-253 1.09e-27

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 117.73  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   98 NAERLDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 177
Cdd:COG4886  114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLS 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252  178 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 253
Cdd:COG4886  191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-491 2.95e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 2.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   97 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQvsviergAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDL 176
Cdd:COG4886   72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDL 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  177 SENQIQGIPrKAFRGITDVKNLQLDNNHISCIeDGAFRALRDLEILTLNNNNISRILvTSFNHMPKIRTLRLHSNHLYcd 256
Cdd:COG4886  144 SNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLT-- 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  257 chlawlsdwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpaphseppscnansiscpspctcsnnivdcrgkglmE 336
Cdd:COG4886  219 -------------------------------------------------------------------------------D 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  337 IPANLPE--GIVEIRLEQNSIKAIPagAFTQYKKLKRIDISKNQISDIAPDAfqGLKSLTSLVLYGNKITEIA-KGLFDG 413
Cdd:COG4886  220 LPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELELL 295

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58801252  414 LVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN 491
Cdd:COG4886  296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-486 6.67e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 6.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   98 NAERLDLDRNNitritkmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLS 177
Cdd:COG4886   97 NLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  178 ENQIQGIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRiLVTSFNHMPKIRTLRLHSNHLYcdc 257
Cdd:COG4886  168 NNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLT--- 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  258 HLAWLsdwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpaphseppscnansiscpspctcsnnivdcrgkglmei 337
Cdd:COG4886  242 DLPEL--------------------------------------------------------------------------- 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  338 pANLPEgIVEIRLEQNSIKAIPAGAftQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAkgLFDGLVSL 417
Cdd:COG4886  247 -GNLTN-LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLL 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252  418 QLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLAD 486
Cdd:COG4886  321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
624-936 1.38e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 1.38e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  624 LTGNQLETVHGRVFRGLSGLKTLMLRSNligcvsnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLlsnpfnc 703
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDL------- 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  704 nchlawlgkwlrkrrivSGNPrcqkpffLKEIPiqdVAIQDFTcdgneesscQLsprcpeqctcmeTVVRCSNKGLRALP 783
Cdd:COG4886  144 -----------------SNNQ-------LTDLP---EPLGNLT---------NL------------KSLDLSNNQLTDLP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  784 R---GMPKdVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRS 860
Cdd:COG4886  176 EelgNLTN-LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTN 251

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252  861 LRVLTLHGNDISSVPEGSfnDLTSLSHLALGTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 936
Cdd:COG4886  252 LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
571-873 1.53e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 1.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  571 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKikevregAFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRS 650
Cdd:COG4886   74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  651 NLIGCVSnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 730
Cdd:COG4886  146 NQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ------------------------------ 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  731 fLKEIPiqdvaiqdftcdgneessCQLSprcpeqctcmetvvrcsnkGLRALprgmpkdvTELYLEGNHLTAVPRELSAL 810
Cdd:COG4886  194 -ITDLP------------------EPLG-------------------NLTNL--------EELDLSGNQLTDLPEPLANL 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 58801252  811 RHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIPVHAfnGLRSLRVLTLHGNDISS 873
Cdd:COG4886  228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
669-895 1.31e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 1.31e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  669 LLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQkpfFLKEIPIQDVAIQDFTCD 748
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDL---LLSSLLLLLSLLLLLLLS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  749 GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALprgmpKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTN 828
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58801252  829 yTFSNMSHLSTLILSYNRLRCIPvHAFNGLRSLRVLTLHGNDISSVPEgSFNDLTSLSHLALGTNPL 895
Cdd:COG4886  154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
362-702 1.74e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 1.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  362 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 441
Cdd:COG4886  108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  442 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 521
Cdd:COG4886  162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  522 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 599
Cdd:COG4886  208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  600 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITT 679
Cdd:COG4886  257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                        330       340
                 ....*....|....*....|...
gi 58801252  680 ITPGAFTTLVSLSTINLLSNPFN 702
Cdd:COG4886  335 VTLTTLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
326-495 2.74e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 92.30  E-value: 2.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  326 IVDCRGKGLMEIPANLPE--GIVEIRLEQNSIKAIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 403
Cdd:COG4886  117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  404 TEIAKGLfdglvslqllllnankinclrvntfQDLQNLNLLSLYDNKLQTISKGLfAPLQSIQTLHLAQN-----PFVCD 478
Cdd:COG4886  195 TDLPEPL-------------------------GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                        170
                 ....*....|....*...
gi 58801252  479 C-HLKWLadYLQDNPIET 495
Cdd:COG4886  249 LtNLEEL--DLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
143-518 2.90e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 2.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  143 DLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENqiqgiprKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEIL 222
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKEL 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  223 TLNNNNISRIlVTSFNHMPKIRTLRLHSNhlycdchlawlsdwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpap 302
Cdd:COG4886  142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNN--------------------------------------------------- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  303 hseppscnansiscpspctcsnnivdcrgkGLMEIP---ANLPEgIVEIRLEQNSIKAIPAgAFTQYKKLKRIDISKNQI 379
Cdd:COG4886  170 ------------------------------QLTDLPeelGNLTN-LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  380 SDIaPDAFQGLKSLTSLVLYGNKITEIAKglfdglvslqllllnankinclrvntFQDLQNLNLLSLYDNKLQTISKglF 459
Cdd:COG4886  218 TDL-PEPLANLTNLETLDLSNNQLTDLPE--------------------------LGNLTNLEELDLSNNQLTDLPP--L 268

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252  460 APLQSIQTLHLAQNPFVcDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKK 518
Cdd:COG4886  269 ANLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
Laminin_G_1 pfam00054
Laminin G domain;
1222-1353 8.17e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 81.21  E-value: 8.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   1222 VATDKDNGILLYKGDNDP---LALELYQGHVRLVYDsLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTP--- 1295
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARptg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252   1296 -KSLGKLQKQPAVGinsPLYLGGIPTSTglSALRQGTDRPlgGFHGCIHEVRINNELQD 1353
Cdd:pfam00054   80 eSPLGATTDLDVDG---PLYVGGLPSLG--VKKRRLAISP--SFDGCIRDVIVNGKPLD 131
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 97-253 1.09e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 1.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   97 RNAERLDLDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQS------TPK 170
Cdd:cd21340   46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPrslaalSNS 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  171 LTRLDLSenqiqgiprkafrgitdvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRL 248
Cdd:cd21340  122 LRVLNIS------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDL 175


                 ....*
gi 58801252  249 HSNHL 253
Cdd:cd21340  176 TGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
372-701 8.32e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 8.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  372 IDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 451
Cdd:COG4886   46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  452 QTISKGLfAPLQSIQTLHLAQNpfvcdchlkwladylqdnpietsgarcssprrlankRISQIKSkkfrcsgsedyrsrf 531
Cdd:COG4886  126 TDLPEEL-ANLTNLKELDLSNN------------------------------------QLTDLPE--------------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  532 ssecfmdlvcpekcrcegTIVDCSNqklvripshlpeyVTDLRLNDNEVSVLEATgiFKKLPNLRKINLSNNKIKEVREg 611
Cdd:COG4886  154 ------------------PLGNLTN-------------LKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITDLPE- 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  612 AFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRSNLIGCVSNdtFAGLSSVRLLSLYDNRITTITPGAftTLVSL 691
Cdd:COG4886  200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNL 274

                        330
                 ....*....|
gi 58801252  692 STINLLSNPF 701
Cdd:COG4886  275 KTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
811-871 1.17e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.86  E-value: 1.17e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252    811 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 871
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
593-653 7.05e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.85  E-value: 7.05e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252    593 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI 653
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
618-677 1.22e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.08  E-value: 1.22e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    618 SVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRI 677
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
195-253 3.97e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 3.97e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252    195 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 253
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
97-157 4.33e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.33e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252     97 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 157
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
169-229 4.64e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.54  E-value: 4.64e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252    169 PKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNI 229
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
347-403 6.79e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 6.79e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 58801252    347 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 403
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
835-895 1.74e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.74e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252    835 SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 895
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
122-181 1.79e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.79e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    122 NLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQI 181
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
641-701 1.82e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.82e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 58801252    641 SGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPF 701
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
146-205 1.91e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.91e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    146 QLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI 205
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 672-750 2.57e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 2.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    672 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 748
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 58801252    749 GN 750
Cdd:TIGR00864   82 EE 83
LRR_8 pfam13855
Leucine rich repeat;
570-629 2.38e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 2.38e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    570 VTDLRLNDNEVSVLEAtGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQL 629
Cdd:pfam13855    3 LRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
790-847 5.64e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 5.64e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252    790 VTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 847
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 770-896 1.49e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.80  E-value: 1.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  770 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 848
Cdd:cd21340    5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  849 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 895
Cdd:cd21340   82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                 .
gi 58801252  896 H 896
Cdd:cd21340  155 S 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
558-826 3.50e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 3.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   558 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 632
Cdd:PRK15370  189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   633 HGRVfrgLSGLKTLMLRSNLIGCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 712
Cdd:PRK15370  257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   713 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 792
Cdd:PRK15370  322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                         250       260       270
                  ....*....|....*....|....*....|....
gi 58801252   793 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 826
Cdd:PRK15370  372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 866-951 5.50e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.25  E-value: 5.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    866 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQCk 942
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80


                   ....*....
gi 58801252    943 gpvDINIVA 951
Cdd:TIGR00864   81 ---DEEYVA 86
PLN03150 PLN03150
hypothetical protein; Provisional
 803-896 9.00e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.21  E-value: 9.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   803 VPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR-CIPvHAFNGLRSLRVLTLHGNDISS-VPEgsfn 880
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIP-ESLGQLTSLRILNLNGNSLSGrVPA---- 508

                          90
                  ....*....|....*.
gi 58801252   881 dltslshlALGTNPLH 896
Cdd:PLN03150  509 --------ALGGRLLH 516
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
733-895 1.16e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   733 KEIPIQDVAIQDF-TCDGNEESSCQLS--------PRCPEQCTcmeTVVrCSNKGLRALPRGMPKDVTELYLEGNHLTAV 803
Cdd:PRK15370  160 KEAANREEAVQRMrDCLKNNKTELRLKilglttipACIPEQIT---TLI-LDNNELKSLPENLQGNIKTLYANSNQLTSI 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   804 PRELSALrhLTLIDLSNNSISMLTNYTfsnMSHLSTLILSYNRLRCIPVHAFNGLRSLRVltlHGNDISSVPEgsfNDLT 883
Cdd:PRK15370  236 PATLPDT--IQEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRYLSV---YDNSIRTLPA---HLPS 304

                         170
                  ....*....|..
gi 58801252   884 SLSHLALGTNPL 895
Cdd:PRK15370  305 GITHLNVQSNSL 316
LRR_8 pfam13855
Leucine rich repeat;
368-413 2.17e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.14  E-value: 2.17e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 58801252    368 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDG 413
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-239 4.48e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 4.48e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   88 LRAVPRGIPR--NAERLDLDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIerGAFQDLKQLERLRLNKNK-----LQVL 160
Cdd:COG4886  217 LTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQltdlkLKEL 292

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252  161 PELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNH 239
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
LRR_8 pfam13855
Leucine rich repeat;
392-475 6.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 6.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    392 SLTSLVLYGNKITEIAKGlfdglvslqllllnankinclrvnTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLA 471
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDG------------------------AFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                   ....
gi 58801252    472 QNPF 475
Cdd:pfam13855   58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 576-895 6.48e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.55  E-value: 6.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   576 NDNEVSVLEATG---------IFKKLPNLRKINLSNNKIK-EVREGAFDGAASVQELMLTGNQLEtvhGRVFRG-LSGLK 644
Cdd:PLN00113   67 NSSRVVSIDLSGknisgkissAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsIPNLE 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   645 TLMLRSNLI-GCVSNDtFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNC----------NCHLAWLG-- 711
Cdd:PLN00113  144 TLDLSNNMLsGEIPND-IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqiprelgqmkSLKWIYLGyn 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   712 -------------KWLRKRRIVSGNPRCQKP-----------FFLKE------IPIQDVAIQDF-TCDGNEESscqLSPR 760
Cdd:PLN00113  223 nlsgeipyeigglTSLNHLDLVYNNLTGPIPsslgnlknlqyLFLYQnklsgpIPPSIFSLQKLiSLDLSDNS---LSGE 299

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   761 CPE---QCTCMETVVRCSNK-------GLRALPRgmpkdVTELYLEGNHLTA-VPRELSALRHLTLIDLSNNSISMLTNY 829
Cdd:PLN00113  300 IPElviQLQNLEILHLFSNNftgkipvALTSLPR-----LQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTGEIPE 374

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252   830 TFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 895
Cdd:PLN00113  375 GLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1110-1146 1.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 58801252 1110 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1146
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
893-942 4.06e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 4.06e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 58801252     893 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 942
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
291-572 1.15e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   291 DVQKKEYVCPAPHSEPPScNANSISCPSPCTCSNNIVDCRGK-GLMEIPANLPEGIVEIRLEQNSIKAIPAGAftqYKKL 369
Cdd:PRK15370  147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   370 KRIDISKNQISDIA---PDAFQGLKsltslvLYGNKITEIAKGLfdgLVSLQLLLLNANKINCLRVNTFQDLQNlnlLSL 446
Cdd:PRK15370  223 KTLYANSNQLTSIPatlPDTIQEME------LSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRY---LSV 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   447 YDNKLQTISKGLfaPlQSIQTLHLAQN-----PFVCDCHLKWL-ADylqDNPIETSGArcSSPRRLANKRISQ----IKS 516
Cdd:PRK15370  291 YDNSIRTLPAHL--P-SGITHLNVQSNsltalPETLPPGLKTLeAG---ENALTSLPA--SLPPELQVLDVSKnqitVLP 362

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252   517 KKFRCSGSEDYRSRfssECFMDLvcPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD 572
Cdd:PRK15370  363 ETLPPTITTLDVSR---NALTNL--PENLPAALQIMQASRNNLVRLPESLPHFRGE 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 85-256 1.44e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.97  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   85 GLGLRAVPRGIPRNA--ERLDLDRNNITRITKMDFAGL---KNLRVLHLEDNQVSV----IERGAFQDLK-QLERLRLNK 154
Cdd:cd00116   67 PRGLQSLLQGLTKGCglQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrLLAKGLKDLPpALEKLVLGR 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  155 NKLQVLP----ELLFQSTPKLTRLDLSENQI--QGIPR--KAFRGITDVKNLQLDNNHISCIED----GAFRALRDLEIL 222
Cdd:cd00116  147 NRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVL 226

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 58801252  223 TLNNNNIS----RILVTSFNHM-PKIRTLRLHSNHLYCD 256
Cdd:cd00116  227 NLGDNNLTdagaAALASALLSPnISLLTLSLSCNDITDD 265
EGF_CA smart00179
Calcium-binding EGF-like domain;
1110-1146 2.61e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.61e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 58801252    1110 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 1146
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
88-253 2.83e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.01  E-value: 2.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    88 LRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHledNQVSVIERGAFQDLKQLERLRlnkNKLQVLPELLFQS 167
Cdd:PRK15370  232 LTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFH---NKISCLPENLPEELRYLSVYD---NSIRTLPAHLPSG 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   168 tpkLTRLDLSENQIQGIPRKAFRGItdvKNLQLDNNHISCIEDGAFRALRDLEIltlNNNnisRILVTSFNHMPKIRTLR 247
Cdd:PRK15370  306 ---ITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSLPASLPPELQVLDV---SKN---QITVLPETLPPTITTLD 373


                  ....*.
gi 58801252   248 LHSNHL 253
Cdd:PRK15370  374 VSRNAL 379
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1034-1067 4.92e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.92e-06
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 58801252 1034 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 1067
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 791-875 1.08e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 1.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  791 TELYLE------GNHLTAVPRELSALRH-LTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIP--VHAFNGLRSL 861
Cdd:cd21340   93 EELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSL 170

                         90
                 ....*....|....
gi 58801252  862 RVLTLHGNDISSVP 875
Cdd:cd21340  171 RELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 170-702 1.79e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   170 KLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISC-IEDGAFRALRDLEILTLNNNNISRILVTSFnhMPKIRTLRL 248
Cdd:PLN00113   70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   249 HSNHLYCDCHLawlsdwlrqrrTVGQFTlcmapvhlrGFNVADVQKKEYVCPAPHSEppscnANSISCPSPCTCSNNIVD 328
Cdd:PLN00113  148 SNNMLSGEIPN-----------DIGSFS---------SLKVLDLGGNVLVGKIPNSL-----TNLTSLEFLTLASNQLVG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   329 crgkglmEIPANLPE--GIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-E 405
Cdd:PLN00113  203 -------QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgP 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   406 IAKGLFDglvslqllllnankinclrvntfqdLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCdchlkwla 485
Cdd:PLN00113  276 IPPSIFS-------------------------LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG-------- 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   486 dylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRfSSECFMDLvcpEKCRCEGTIVD--CSNQKLVR-- 561
Cdd:PLN00113  323 --------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH-NNLTVLDL---STNNLTGEIPEglCSSGNLFKli 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   562 -----IPSHLPEYVTD------LRLNDNEVSVlEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLE 630
Cdd:PLN00113  387 lfsnsLEGEIPKSLGAcrslrrVRLQDNSFSG-ELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF 465

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 58801252   631 TVHGRVFRGlSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 702
Cdd:PLN00113  466 GGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 446-509 2.41e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.41e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58801252    446 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 509
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-216 2.73e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    98 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLS 177
Cdd:PLN00113  476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 58801252   178 ENQIQGIPRKAFRGITDVKNLQLDNNHI--SCIEDGAFRAL 216
Cdd:PLN00113  556 QNQLSGEIPKNLGNVESLVQVNISHNHLhgSLPSTGAFLAI 596
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1036-1065 3.29e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.29e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 58801252   1036 CEDNDCENNATCVDGINNYVCICPPNYTGE 1065
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 992-1030 3.37e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.37e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 58801252  992 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 1030
Cdd:cd00054    2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1159-1189 3.66e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.66e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 58801252   1159 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1189
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1114-1144 4.00e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 4.00e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 58801252   1114 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1144
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1071-1108 4.10e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.10e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 58801252 1071 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1108
Cdd:cd00054    2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 96-258 4.64e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   96 PRNAERLDLDRNNIT-----RITKMdFAGLKNLRVLHLEDNQVSviERGA------FQDLKQLERLRLNKNKLQV----- 159
Cdd:COG5238  263 NTTVETLYLSGNQIGaegaiALAKA-LQGNTTLTSLDLSVNRIG--DEGAialaegLQGNKTLHTLNLAYNGIGAqgaia 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  160 LPELLfQSTPKLTRLDLSENQIQGIPRKAF----RGITDVKNLQLDNNHISciEDGAfRALRDLeiltLNNNnisrilvt 235
Cdd:COG5238  340 LAKAL-QENTTLHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIG--KQGA-EALIDA----LQTN-------- 403

                        170       180
                 ....*....|....*....|...
gi 58801252  236 sfnhmpKIRTLRLHSNHLYCDCH 258
Cdd:COG5238  404 ------RLHTLILDGNLIGAEAQ 420
LRRCT smart00082
Leucine rich repeat C-terminal domain;
699-748 7.03e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 7.03e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 58801252     699 NPFNCNCHLAWLGKWLRKRRIVSG--NPRCQKPFFLKEiPIQDVAIQDFTCD 748
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRG-PLLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
69-100 7.90e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.90e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 58801252      69 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 100
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 69-96 8.10e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 8.10e-05
                           10        20
                   ....*....|....*....|....*...
gi 58801252     69 ACPTKCTCSAASVDCHGLGLRAVPRGIP 96
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 224-286 1.13e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.00  E-value: 1.13e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252    224 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 286
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
LRRNT smart00013
Leucine rich repeat N-terminal domain;
761-792 1.42e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.42e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 58801252     761 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 792
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 101-251 1.65e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  101 RLDLDRNNITRI-TKMDFAGLKNLRVLHLEDNQVSVIE----RGAFQDLKQLERLRLNKNKLQVLPELL------FQSTP 169
Cdd:cd00116    2 QLSLKGELLKTErATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  170 KLTRLDLSEN--QIQGIPR-KAFRGITDVKNLQLDNN--------------------------------HISCIE-DGAF 213
Cdd:cd00116   82 GLQELDLSDNalGPDGCGVlESLLRSSSLQELKLNNNglgdrglrllakglkdlppaleklvlgrnrleGASCEAlAKAL 161

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 58801252  214 RALRDLEILTLNNNNIS----RILVTSFNHMPKIRTLRLHSN 251
Cdd:cd00116  162 RANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNN 203
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1117-1146 1.67e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.15  E-value: 1.67e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 58801252 1117 HKCRHGAQCVDTINGYTCTCPQGFSGPF-CE 1146
Cdd:cd00053    6 NPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1034-1063 1.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.80e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 58801252    1034 DDCE-DNDCENNATCVDGINNYVCICPPNYT 1063
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1200-1347 2.20e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 43.14  E-value: 2.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   1200 GKDSYVELASAKVRPQAN-ISLQVATDKDNG---ILLYKGDNDPLALELYQ-GHVRLVYDSLSSPPTTVYSVETVNDGQF 1274
Cdd:pfam13385    2 GGSDYVTLPDALLPTSDFtVSAWVKPDSLPGwarAIISSSGGGGYSLGLDGdGRLRFAVNGGNGGWDTVTSGASVPLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 58801252   1275 HSVeLVTLN-QTLNLVVDkGTPKSLGKLQKQPAVGINSPLYLGGiptstglsalRQGTDRPlggFHGCIHEVRI 1347
Cdd:pfam13385   82 THV-AVTYDgGTLRLYVN-GVLVGSSTLTGGPPPGTGGPLYIGR----------SPGGDDY---FNGLIDEVRI 140
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1119-1140 2.56e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.62  E-value: 2.56e-04
                           10        20
                   ....*....|....*....|..
gi 58801252   1119 CRHGAQCVDTINGYTCTCPQGF 1140
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1502-1557 3.38e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.85  E-value: 3.38e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252    1502 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1557
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-410 3.43e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    97 RNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSvieRGAFQDL-KQ--LERLRLNKNKLQ-VLPELLFQSTpKLT 172
Cdd:PLN00113  308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS---GEIPKNLgKHnnLTVLDLSTNNLTgEIPEGLCSSG-NLF 383

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   173 RLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNH 252
Cdd:PLN00113  384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   253 LYCDchlawLSDWLRQRRtvgqftlcmapvhLRGFNVADvqkkeyvcpaphseppscnaNSISCPSPctcsnnivdcrgK 332
Cdd:PLN00113  464 FFGG-----LPDSFGSKR-------------LENLDLSR--------------------NQFSGAVP------------R 493

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252   333 GLMeipaNLPEgIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-EIAKGL 410
Cdd:PLN00113  494 KLG----SLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 367-406 4.53e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 4.53e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 58801252    367 KKLKRIDISKNQISDIapDAFQGLKSLTSLVLYGN-KITEI 406
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDL 39
LRRCT smart00082
Leucine rich repeat C-terminal domain;
473-503 6.62e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 6.62e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 58801252     473 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 503
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1071-1108 7.06e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.06e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 58801252    1071 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 1108
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 571-701 7.35e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 7.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  571 TDLRLNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVrEGaFDGAASVQELMLTGNQLE-----TVHGRVFRGLSG-LK 644
Cdd:cd21340   49 THLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLR 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 58801252  645 TLMLRSNLIGCVSNdtFAGLSSVRLLSLYDNRITTITP--GAFTTLVSLSTINLLSNPF 701
Cdd:cd21340  124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-254 7.59e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   102 LDLDRNNIT-RITKMDFAgLKNLRVLHLEDNQVSvierGAFQDL---KQLERLRLNKNKLQVLPELLFQSTPKLTRLDLS 177
Cdd:PLN00113  433 LDISNNNLQgRINSRKWD-MPSLQMLSLARNKFF----GGLPDSfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58801252   178 ENQIQG-IPRKaFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLY 254
Cdd:PLN00113  508 ENKLSGeIPDE-LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 360-492 8.24e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 8.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252  360 AGAFTQYKKLKRIDISKNQISD-----IApDAFQGLKSLTSLVLYGNKITE-----IAKGLfDGLVSLQLLLLNANKI-- 427
Cdd:COG5238  229 AEALKGNKSLTTLDLSNNQIGDegviaLA-EALKNNTTVETLYLSGNQIGAegaiaLAKAL-QGNTTLTSLDLSVNRIgd 306

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 58801252  428 -------NCLRVNtfqdlQNLNLLSLYDNKLQTI-SKGLFAPLQ---SIQTLHLAQNPfVCDCHLKWLADYLQDNP 492
Cdd:COG5238  307 egaialaEGLQGN-----KTLHTLNLAYNGIGAQgAIALAKALQentTLHSLDLSDNQ-IGDEGAIALAKYLEGNT 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-451 9.38e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 9.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    91 VPR--GIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELLFqS 167
Cdd:PLN00113  204 IPRelGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-S 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   168 TPKLTRLDLSENQIQG-IPRKafrgITDVKNLQ---LDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKI 243
Cdd:PLN00113  283 LQKLISLDLSDNSLSGeIPEL----VIQLQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   244 RTLRLHSNHL-------YCDC-HLawlsdwlrqrrtvgqFTLCMAPVHLRGfnvaDVQKKEYVCPAPHSEPPSCNANSIS 315
Cdd:PLN00113  359 TVLDLSTNNLtgeipegLCSSgNL---------------FKLILFSNSLEG----EIPKSLGACRSLRRVRLQDNSFSGE 419

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   316 CPSPCT----------CSNNIVDCRGKGLMEIPAnlpegIVEIRLEQNSIKA-IPAgaFTQYKKLKRIDISKNQISDIAP 384
Cdd:PLN00113  420 LPSEFTklplvyfldiSNNNLQGRINSRKWDMPS-----LQMLSLARNKFFGgLPD--SFGSKRLENLDLSRNQFSGAVP 492

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 58801252   385 DAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 451
Cdd:PLN00113  493 RKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRRNT smart00013
Leucine rich repeat N-terminal domain;
316-347 1.43e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 58801252     316 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 347
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 316-342 1.73e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.73e-03
                           10        20
                   ....*....|....*....|....*..
gi 58801252    316 CPSPCTCSNNIVDCRGKGLMEIPANLP 342
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
541-571 1.98e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 1.98e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 58801252     541 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVT 571
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1037-1065 2.39e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.39e-03
                         10        20
                 ....*....|....*....|....*....
gi 58801252 1037 EDNDCENNATCVDGINNYVCICPPNYTGE 1065
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
LRR smart00370
Leucine-rich repeats, outliers;
592-615 2.49e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.49e-03
                            10        20
                    ....*....|....*....|....
gi 58801252     592 LPNLRKINLSNNKIKEVREGAFDG 615
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
592-615 2.49e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.49e-03
                            10        20
                    ....*....|....*....|....
gi 58801252     592 LPNLRKINLSNNKIKEVREGAFDG 615
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 761-787 2.67e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.67e-03
                           10        20
                   ....*....|....*....|....*..
gi 58801252    761 CPEQCTCMETVVRCSNKGLRALPRGMP 787
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1041-1060 2.94e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 2.94e-03
                           10        20
                   ....*....|....*....|
gi 58801252   1041 CENNATCVDGINNYVCICPP 1060
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1107-1142 3.08e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 3.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 58801252   1107 CETDNDDCVAHkcrhgAQCVDTINGYTCTCPQGFSG 1142
Cdd:pfam12947    1 CSDNNGGCHPN-----ATCTNTGGSFTCTCNDGYTG 31
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 107-213 3.11e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.45  E-value: 3.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    107 NNITRITKMDFAGLKNLRVLHLEDNqVSVIERGAFQDLKqLERLRLNKNkLQVLPELLFQSTPKLTRLDLSENqIQGIPR 186
Cdd:pfam13306   20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                           90       100
                   ....*....|....*....|....*..
gi 58801252    187 KAFRGiTDVKNLQLDNNHIScIEDGAF 213
Cdd:pfam13306   96 YAFSN-CSLKSITIPSSVTT-IGSYAF 120
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1408-1436 3.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.13e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 58801252   1408 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1436
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 91-603 3.57e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    91 VPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL--QVLPELLFQST 168
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgQIPRELGQMKS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   169 PKLtrLDLSENQIQG-IPrKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLR 247
Cdd:PLN00113  214 LKW--IYLGYNNLSGeIP-YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLD 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   248 LHSNHLYCDchlawLSDWLRQRRTvgqftlcMAPVHLRGFNVADvQKKEYVCPAPHSEPPSCNANSISCpspctcsnniv 327
Cdd:PLN00113  291 LSDNSLSGE-----IPELVIQLQN-------LEILHLFSNNFTG-KIPVALTSLPRLQVLQLWSNKFSG----------- 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   328 dcrgkglmEIPANLPEgiveirleQNSikaipagaftqykkLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI-TEI 406
Cdd:PLN00113  347 --------EIPKNLGK--------HNN--------------LTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLeGEI 396

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   407 AKGLFDGLVSLQLLLLNaNKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDchlkwLAD 486
Cdd:PLN00113  397 PKSLGACRSLRRVRLQD-NSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG-----LPD 470

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252   487 YLQDNPIETsgarcsspRRLANKRISQIKSKKFRcSGSEDYRSRFSSECFMDLVCPEKCRCEGTI-VDCSNQKLV-RIPS 564
Cdd:PLN00113  471 SFGSKRLEN--------LDLSRNQFSGAVPRKLG-SLSELMQLKLSENKLSGEIPDELSSCKKLVsLDLSHNQLSgQIPA 541

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 58801252   565 HLPEY--VTDLRLNDNEVSVlEATGIFKKLPNLRKINLSNN 603
Cdd:PLN00113  542 SFSEMpvLSQLDLSQNQLSG-EIPKNLGNVESLVQVNISHN 581
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 995-1028 3.71e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 3.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 58801252    995 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 1028
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1030 4.86e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.86e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 58801252     998 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 1030
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
LRR_9 pfam14580
Leucine-rich repeat;
575-658 5.88e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 5.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58801252    575 LNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGrvFRGLSGLKTLMLRSNLIG 654
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGD--LDPLASLKKLTFLSLLRN 123


                   ....
gi 58801252    655 CVSN 658
Cdd:pfam14580  124 PVTN 127
LRR smart00370
Leucine-rich repeats, outliers;
169-191 6.39e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.39e-03
                            10        20
                    ....*....|....*....|...
gi 58801252     169 PKLTRLDLSENQIQGIPRKAFRG 191
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
169-191 6.39e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.39e-03
                            10        20
                    ....*....|....*....|...
gi 58801252     169 PKLTRLDLSENQIQGIPRKAFRG 191
Cdd:smart00369    2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
858-881 7.05e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 7.05e-03
                            10        20
                    ....*....|....*....|....
gi 58801252     858 LRSLRVLTLHGNDISSVPEGSFND 881
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
858-881 7.05e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 7.05e-03
                            10        20
                    ....*....|....*....|....
gi 58801252     858 LRSLRVLTLHGNDISSVPEGSFND 881
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 121-157 7.28e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 7.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 58801252    121 KNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKL 157
Cdd:pfam12799    1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 169-210 8.44e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 8.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 58801252    169 PKLTRLDLSENQIQGIPrkAFRGITDVKNLQL-DNNHISCIED 210
Cdd:pfam12799    1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLsGNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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