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Conserved domains on  [gi|586946368|ref|NP_001277014|]
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zinc finger protein 627 isoform 3 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-272 3.86e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368  64 ETFISLVSIRRHMLTHRG-GVPYKCKVCGKAFDYPSLFRIHERS--HTGE--KPYEC--KQCGKAFSCSSYIRIHERTHT 136
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368 137 GDKPYECK--QCGKAFSCSKYIRIHERT--HTGEKPYECKQCGKAFRCASSVRSHerthtgeklfeckecgkaltclaSV 212
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS-----------------------NL 404

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 586946368 213 RRHMIKHTGNGP--YKCKVCGKAFDFPSSFRIHERTHTGEKPYDCKQCGKAFSCSSSFRKHE 272
Cdd:COG5048  405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-292 5.75e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 5.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 586946368  267 SFRKHERIHTGEKPYKCTKCGKAFSR 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.10e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 586946368  295 YFRIHERTHTGEKPYECKQCGKAFSR 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-272 3.86e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368  64 ETFISLVSIRRHMLTHRG-GVPYKCKVCGKAFDYPSLFRIHERS--HTGE--KPYEC--KQCGKAFSCSSYIRIHERTHT 136
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368 137 GDKPYECK--QCGKAFSCSKYIRIHERT--HTGEKPYECKQCGKAFRCASSVRSHerthtgeklfeckecgkaltclaSV 212
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS-----------------------NL 404

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 586946368 213 RRHMIKHTGNGP--YKCKVCGKAFDFPSSFRIHERTHTGEKPYDCKQCGKAFSCSSSFRKHE 272
Cdd:COG5048  405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-292 5.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 5.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 586946368  267 SFRKHERIHTGEKPYKCTKCGKAFSR 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 586946368  295 YFRIHERTHTGEKPYECKQCGKAFSR 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
100-124 2.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|....*
gi 586946368  100 FRIHERSHTGEKPYECKQCGKAFSC 124
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-272 3.86e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368  64 ETFISLVSIRRHMLTHRG-GVPYKCKVCGKAFDYPSLFRIHERS--HTGE--KPYEC--KQCGKAFSCSSYIRIHERTHT 136
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368 137 GDKPYECK--QCGKAFSCSKYIRIHERT--HTGEKPYECKQCGKAFRCASSVRSHerthtgeklfeckecgkaltclaSV 212
Cdd:COG5048  348 SISPAKEKllNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDS-----------------------NL 404

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 586946368 213 RRHMIKHTGNGP--YKCKVCGKAFDFPSSFRIHERTHTGEKPYDCKQCGKAFSCSSSFRKHE 272
Cdd:COG5048  405 SLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-328 8.64e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 8.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368 138 DKPYECKQCGKAFSCSKYIRIHERT--HTGE--KPYEC--KQCGKAFRCASSVRSHERTHTGEKLFECKEcgkaltclas 211
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKL---------- 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368 212 vRRHMIKHTGNGPYKckvcgkafdfPSSFRIHERTHTGEKPYDC--KQCGKAFSCSSSFRKHERIHTGEKP--YKCTKCG 287
Cdd:COG5048  357 -LNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 586946368 288 KAFSRSSYFRIHERTHTGEKPYECKQCGKAFSRSTYFRVHE 328
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-292 5.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 5.75e-04
                          10        20
                  ....*....|....*....|....*.
gi 586946368  267 SFRKHERIHTGEKPYKCTKCGKAFSR 292
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
295-320 1.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 586946368  295 YFRIHERTHTGEKPYECKQCGKAFSR 320
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
100-124 2.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|....*
gi 586946368  100 FRIHERSHTGEKPYECKQCGKAFSC 124
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
155-180 2.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 586946368  155 YIRIHERTHTGEKPYECKQCGKAFRC 180
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
127-152 3.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 586946368  127 YIRIHERTHTGDKPYECKQCGKAFSC 152
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-341 3.08e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586946368 279 KPYKCTKCGKAFSRSSYFRIHERT--HTGE--KPYEC--KQCGKAFSRSTYFRVHEKIHTGEKPYENPN 341
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKL 356
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
27-188 3.33e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368  27 KSYTRNQCGRALS----YHRSFPVRERTHPGGKPYDCKE--CGETFISLVSIRRHMLTHRGGVPYKCK--VCGKAFD--- 95
Cdd:COG5048  288 LPIKSKQCNISFSrsspLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368  96 --YPSLFRIHERSHTGEKPYEC--KQCGKAFSCSSYIRIHERTHTGDKPYECK--QCGKAFSCSKYIRIHERTHTGEKPY 169
Cdd:COG5048  368 nnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 586946368 170 ECKQCGKAFRCASSVRSHE 188
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-264 3.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.57e-03
                          10        20
                  ....*....|....*....|....*.
gi 586946368  239 SFRIHERTHTGEKPYDCKQCGKAFSC 264
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-234 5.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.04e-03
                          10        20
                  ....*....|....*....|....
gi 586946368  211 SVRRHMIKHTGNGPYKCKVCGKAF 234
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-332 5.64e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 5.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368 198 ECKECGKALTCLASVRRHMIKHTGNG-------PYKCKVCGKAFDFPSSFRIHERT--HTGE--KPYDC--KQCGKAFSC 264
Cdd:COG5048  256 SASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSR 335

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946368 265 SSSFRKHERIHTGEKPYKCT-------------------------------------KCGKAFSRSSYFRIHERTHTGEK 307
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLSLHIITHLSFR 415

                        170       180
                 ....*....|....*....|....*..
gi 586946368 308 PYECK--QCGKAFSRSTYFRVHEKIHT 332
Cdd:COG5048  416 PYNCKnpPCSKSFNRHYNLIPHKKIHT 442
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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