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Conserved domains on  [gi|584372722|gb|EWG92652|]
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Fun19p [Saccharomyces cerevisiae P301]

Protein Classification

SWIRM domain-containing protein( domain architecture ID 10516817)

SWIRM domain-containing protein similar to Schizosaccharomyces pombe SWIRM domain-containing proteins laf1 and laf2, which are components of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 331-409 5.06e-14

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


:

Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 66.82  E-value: 5.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584372722  331 PLRNELHPAELVLAQTLR----LPCDLYLDSKRRLFLEkvYRLKKGLPFRRTDAQKACRIDVNKASRLFQAFEKVGWLqd 406
Cdd:pfam04433   1 SDPDKLHPIEKRLLPEFFngksKTPEVYLEIRNFILNL--WRENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLI-- 76


                  ...
gi 584372722  407 sNF 409
Cdd:pfam04433  77 -NF 78
 
Name Accession Description Interval E-value
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 331-409 5.06e-14

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 66.82  E-value: 5.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584372722  331 PLRNELHPAELVLAQTLR----LPCDLYLDSKRRLFLEkvYRLKKGLPFRRTDAQKACRIDVNKASRLFQAFEKVGWLqd 406
Cdd:pfam04433   1 SDPDKLHPIEKRLLPEFFngksKTPEVYLEIRNFILNL--WRENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLI-- 76


                  ...
gi 584372722  407 sNF 409
Cdd:pfam04433  77 -NF 78
COG5114 COG5114
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
323-404 3.30e-03

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 39.67  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584372722 323 SPMDLSTDPLRNELHPAELVLAQTLRLPCDLYLDSKRRLFLEKvyrLKKGLPFRRTDAQKACRIDVNKASRLFQAFEKVG 402
Cdd:COG5114  350 TISDIQHAPDYALLSDDEQRLCETLNISPKPYLELKKEVISCF---LRTRGEFTKEDFNRLFGIDLGKADGLYDFFLERG 426


                 ..
gi 584372722 403 WL 404
Cdd:COG5114  427 WI 428
 
Name Accession Description Interval E-value
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 331-409 5.06e-14

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 66.82  E-value: 5.06e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584372722  331 PLRNELHPAELVLAQTLR----LPCDLYLDSKRRLFLEkvYRLKKGLPFRRTDAQKACRIDVNKASRLFQAFEKVGWLqd 406
Cdd:pfam04433   1 SDPDKLHPIEKRLLPEFFngksKTPEVYLEIRNFILNL--WRENPKEYLTKTDARRALKGDVNLISRIHEFLERWGLI-- 76


                  ...
gi 584372722  407 sNF 409
Cdd:pfam04433  77 -NF 78
COG5114 COG5114
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
323-404 3.30e-03

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 39.67  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584372722 323 SPMDLSTDPLRNELHPAELVLAQTLRLPCDLYLDSKRRLFLEKvyrLKKGLPFRRTDAQKACRIDVNKASRLFQAFEKVG 402
Cdd:COG5114  350 TISDIQHAPDYALLSDDEQRLCETLNISPKPYLELKKEVISCF---LRTRGEFTKEDFNRLFGIDLGKADGLYDFFLERG 426


                 ..
gi 584372722 403 WL 404
Cdd:COG5114  427 WI 428
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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