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Conserved domains on  [gi|582041999|ref|WP_024131605|]
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MULTISPECIES: TraB/VirB10 family protein [Gammaproteobacteria]

Protein Classification

TraB/VirB10 family protein( domain architecture ID 11611843)

TraB/VirB10 family protein forms part of core complex in Type IV secretion system; TraB is a VirB10 homolog and a component of the type IV secretion system (T4SS)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TraB cd16430
TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS) ...
 224-427 1.69e-108

TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS); This family contains TraB (VirB10 homolog) and a component of the type IV secretion system (T4SS), and similar proteins. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TraB is localized similarly to related proteins in other systems, but unlike in other systems, Neisseria gonorrhoeae TraB does not require the presence of other T4SS components for proper localization. It has been shown to be expressed with TraK (VirB9 homolog) at low levels in wild-type cells, suggesting that gonococcal T4SS may be present in single copy per cell and the small amounts of these proteins are sufficient for DNA secretion.


:

Pssm-ID: 319756  Cd Length: 203  Bit Score: 318.68  E-value: 1.69e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 224 YLPSGSILTGVLINGMDAPTSQGARRDPFPSTLRIQKEAILPNRFRADVRECFLIVSGYGDLSSERAYLRGETFSCVRDD 303
Cdd:cd16430    1 YLPAGSFARAVLLTGVDAPTGVQAQSNPVPVLLRIKDDAILPNGFRSDLKGCFVLGSAYGDLSSERAYIRLESLSCIRKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 304 GGVIEAKLDSYAVGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAFDVNPVPVVSTNPGsnTQYQSVFSDQMLQGAA 383
Cdd:cd16430   81 GKVIEVPVKGYVVGEDGKAGIRGRVVSKQGQLLARALLAGFLSGLGQAFQQAATTTSTTSGL--GTTQTIDPGDALKAGA 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 582041999 384 VKGASKALDRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKGTKL 427
Cdd:cd16430  159 GGGASSALDKLADYYLKLAEQMFPVIEVDAGREVDVVFTEGFSL 202
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 37-130 4.67e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.23  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999   37 KKEEKrgrqeTIKHVLTDKNTReigIDSLSAD-VKMVSRENSD------LKKELERVKKELEETKTTAGKSSDvgrEMTR 109
Cdd:TIGR04523  81 EQQIK-----DLNDKLKKNKDK---INKLNSDlSKINSEIKNDkeqknkLEVELNKLEKQKKENKKNIDKFLT---EIKK 149

                          90       100
                  ....*....|....*....|.
gi 582041999  110 LRQDLDRLTQKNMELAKKVET 130
Cdd:TIGR04523 150 KEKELEKLNNKYNDLKKQKEE 170
 
Name Accession Description Interval E-value
TraB cd16430
TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS) ...
 224-427 1.69e-108

TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS); This family contains TraB (VirB10 homolog) and a component of the type IV secretion system (T4SS), and similar proteins. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TraB is localized similarly to related proteins in other systems, but unlike in other systems, Neisseria gonorrhoeae TraB does not require the presence of other T4SS components for proper localization. It has been shown to be expressed with TraK (VirB9 homolog) at low levels in wild-type cells, suggesting that gonococcal T4SS may be present in single copy per cell and the small amounts of these proteins are sufficient for DNA secretion.


Pssm-ID: 319756  Cd Length: 203  Bit Score: 318.68  E-value: 1.69e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 224 YLPSGSILTGVLINGMDAPTSQGARRDPFPSTLRIQKEAILPNRFRADVRECFLIVSGYGDLSSERAYLRGETFSCVRDD 303
Cdd:cd16430    1 YLPAGSFARAVLLTGVDAPTGVQAQSNPVPVLLRIKDDAILPNGFRSDLKGCFVLGSAYGDLSSERAYIRLESLSCIRKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 304 GGVIEAKLDSYAVGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAFDVNPVPVVSTNPGsnTQYQSVFSDQMLQGAA 383
Cdd:cd16430   81 GKVIEVPVKGYVVGEDGKAGIRGRVVSKQGQLLARALLAGFLSGLGQAFQQAATTTSTTSGL--GTTQTIDPGDALKAGA 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 582041999 384 VKGASKALDRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKGTKL 427
Cdd:cd16430  159 GGGASSALDKLADYYLKLAEQMFPVIEVDAGREVDVVFTEGFSL 202
TrbI pfam03743
Bacterial conjugation TrbI-like protein; Although not essential for conjugation, the TrbI ...
 224-424 2.90e-36

Bacterial conjugation TrbI-like protein; Although not essential for conjugation, the TrbI protein greatly increase the conjugational efficiency.


Pssm-ID: 427480  Cd Length: 187  Bit Score: 131.62  E-value: 2.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999  224 YLPSGSILTGVLINGMDAPTSQGAR-RDPFPSTLRIQKEAIL-PNRFRA-DVRECFlivSGYGdlsSERAYLRGETFSCV 300
Cdd:pfam03743   1 YLPAGTVIPAVLITGINSDLPGQVTaQVTEPVYDSATGRALLiPKGSRLiGEYGSG---VAYG---QERVLVVWTRLICP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999  301 rdDGGVIEakLDSYA-VGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAfdvnpvpvvsTNPGSNTQYQSVFSDQML 379
Cdd:pfam03743  75 --DGVSID--LDSPGgVDALGRAGLRGRVDNHFGQRFGAALLLSLLGGGGEL----------ANAASSNSTSTSTGNDNL 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 582041999  380 QGAAVKGASKALDRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKG 424
Cdd:pfam03743 141 LGAVGSGAGQALSQLAQQILERALNIPPTITVRQGTRVRIIVNRD 185
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 76-428 1.81e-33

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 131.10  E-value: 1.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999  76 NSDLKKELERVKKELEEtkttagkssdVGREMTRLRQDLDRLTQKNMELAKKVETGAAGGKTSSSsEDARADVNGASGGD 155
Cdd:PRK13729  78 AAQMQKQYEEIRRELDV----------LNKQRGDDQRRIEKLGQDNAALAEQVKALGANPVTATG-EPVPQMPASPPGPE 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 156 GQFMEKKLDYKDPASFFRDAPLPDS--KGGAPATGKGDGRDATKP--GIQIVSYSQkapeveEKDNKDDESIYLPSGSIL 231
Cdd:PRK13729 147 GEPQPGNTPVSFPPQGSVAVPPPTAfyPGNGVTPPPQVTYQSVPVpnRIQRKTFTY------NEGKKGPSLPYIPSGSFA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 232 TGVLINGMDAPTSQGARRDPFPSTLRIQKEAILPNRFRADVRECFLIVSGYGDLSSERAYLRGETFSCVRdDGGVIEAKL 311
Cdd:PRK13729 221 KAMLIEGADANASVTGNESTVPMQLRITGLVEMPNSKTYDATGCFVGLEAWGDVSSERAIVRTRNISCLK-NGKTIDMPI 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 312 DSYaVGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAFDVNPVPVVSTnpGSNTQYQSvfSDQMLQGAAvKGASKAL 391
Cdd:PRK13729 300 KGH-VSFRGKNGIKGEVVMRNGKILGWAWGAGFVDGIGQGMERASQPAVGL--GATAAYGA--GDVLKMGIG-GGASKAA 373

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 582041999 392 DRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKGTKLQ 428
Cdd:PRK13729 374 QTLSDYYIKRAEQYHPVIPIGAGNEVTVVFQDGFQLK 410
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 37-130 4.67e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.23  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999   37 KKEEKrgrqeTIKHVLTDKNTReigIDSLSAD-VKMVSRENSD------LKKELERVKKELEETKTTAGKSSDvgrEMTR 109
Cdd:TIGR04523  81 EQQIK-----DLNDKLKKNKDK---INKLNSDlSKINSEIKNDkeqknkLEVELNKLEKQKKENKKNIDKFLT---EIKK 149

                          90       100
                  ....*....|....*....|.
gi 582041999  110 LRQDLDRLTQKNMELAKKVET 130
Cdd:TIGR04523 150 KEKELEKLNNKYNDLKKQKEE 170
 
Name Accession Description Interval E-value
TraB cd16430
TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS) ...
 224-427 1.69e-108

TraB is a homolog of VirB10 which forms part of core complex in Type IV secretion system (T4SS); This family contains TraB (VirB10 homolog) and a component of the type IV secretion system (T4SS), and similar proteins. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TraB is localized similarly to related proteins in other systems, but unlike in other systems, Neisseria gonorrhoeae TraB does not require the presence of other T4SS components for proper localization. It has been shown to be expressed with TraK (VirB9 homolog) at low levels in wild-type cells, suggesting that gonococcal T4SS may be present in single copy per cell and the small amounts of these proteins are sufficient for DNA secretion.


Pssm-ID: 319756  Cd Length: 203  Bit Score: 318.68  E-value: 1.69e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 224 YLPSGSILTGVLINGMDAPTSQGARRDPFPSTLRIQKEAILPNRFRADVRECFLIVSGYGDLSSERAYLRGETFSCVRDD 303
Cdd:cd16430    1 YLPAGSFARAVLLTGVDAPTGVQAQSNPVPVLLRIKDDAILPNGFRSDLKGCFVLGSAYGDLSSERAYIRLESLSCIRKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 304 GGVIEAKLDSYAVGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAFDVNPVPVVSTNPGsnTQYQSVFSDQMLQGAA 383
Cdd:cd16430   81 GKVIEVPVKGYVVGEDGKAGIRGRVVSKQGQLLARALLAGFLSGLGQAFQQAATTTSTTSGL--GTTQTIDPGDALKAGA 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 582041999 384 VKGASKALDRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKGTKL 427
Cdd:cd16430  159 GGGASSALDKLADYYLKLAEQMFPVIEVDAGREVDVVFTEGFSL 202
TrbI pfam03743
Bacterial conjugation TrbI-like protein; Although not essential for conjugation, the TrbI ...
 224-424 2.90e-36

Bacterial conjugation TrbI-like protein; Although not essential for conjugation, the TrbI protein greatly increase the conjugational efficiency.


Pssm-ID: 427480  Cd Length: 187  Bit Score: 131.62  E-value: 2.90e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999  224 YLPSGSILTGVLINGMDAPTSQGAR-RDPFPSTLRIQKEAIL-PNRFRA-DVRECFlivSGYGdlsSERAYLRGETFSCV 300
Cdd:pfam03743   1 YLPAGTVIPAVLITGINSDLPGQVTaQVTEPVYDSATGRALLiPKGSRLiGEYGSG---VAYG---QERVLVVWTRLICP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999  301 rdDGGVIEakLDSYA-VGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAfdvnpvpvvsTNPGSNTQYQSVFSDQML 379
Cdd:pfam03743  75 --DGVSID--LDSPGgVDALGRAGLRGRVDNHFGQRFGAALLLSLLGGGGEL----------ANAASSNSTSTSTGNDNL 140

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 582041999  380 QGAAVKGASKALDRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKG 424
Cdd:pfam03743 141 LGAVGSGAGQALSQLAQQILERALNIPPTITVRQGTRVRIIVNRD 185
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 76-428 1.81e-33

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 131.10  E-value: 1.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999  76 NSDLKKELERVKKELEEtkttagkssdVGREMTRLRQDLDRLTQKNMELAKKVETGAAGGKTSSSsEDARADVNGASGGD 155
Cdd:PRK13729  78 AAQMQKQYEEIRRELDV----------LNKQRGDDQRRIEKLGQDNAALAEQVKALGANPVTATG-EPVPQMPASPPGPE 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 156 GQFMEKKLDYKDPASFFRDAPLPDS--KGGAPATGKGDGRDATKP--GIQIVSYSQkapeveEKDNKDDESIYLPSGSIL 231
Cdd:PRK13729 147 GEPQPGNTPVSFPPQGSVAVPPPTAfyPGNGVTPPPQVTYQSVPVpnRIQRKTFTY------NEGKKGPSLPYIPSGSFA 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 232 TGVLINGMDAPTSQGARRDPFPSTLRIQKEAILPNRFRADVRECFLIVSGYGDLSSERAYLRGETFSCVRdDGGVIEAKL 311
Cdd:PRK13729 221 KAMLIEGADANASVTGNESTVPMQLRITGLVEMPNSKTYDATGCFVGLEAWGDVSSERAIVRTRNISCLK-NGKTIDMPI 299

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 312 DSYaVGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAFDVNPVPVVSTnpGSNTQYQSvfSDQMLQGAAvKGASKAL 391
Cdd:PRK13729 300 KGH-VSFRGKNGIKGEVVMRNGKILGWAWGAGFVDGIGQGMERASQPAVGL--GATAAYGA--GDVLKMGIG-GGASKAA 373

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 582041999 392 DRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKGTKLQ 428
Cdd:PRK13729 374 QTLSDYYIKRAEQYHPVIPIGAGNEVTVVFQDGFQLK 410
VirB10_like cd16426
VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS); This ...
 225-427 2.44e-32

VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS); This family contains VirB10, a component of the type IV secretion system (T4SS) and its homologs, including TraB, TraF, IcmE, and similar proteins. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10 interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. In Gram-negative bacterial pathogen Helicobacter pylori, an important aetiological agent of gastroduodenal disease in humans, the comB3 gene encodes protein with best homologies to TraS/TraB from the Pseudomonas aeruginosa conjugative plasmid RP1 and TrbI of plasmid RP4 and VirB10 from the Ti plasmid of Agrobacterium tumefaciens, as well as DotG/IcmE of Legionella pneumophila.


Pssm-ID: 319754 [Multi-domain]  Cd Length: 151  Bit Score: 119.95  E-value: 2.44e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 225 LPSGSILTGVLINGMDAPtsqgarrDPFPSTLRIQKEAILPNRFR-ADVRECFLIVSGYGDLSS-ERAYLRGETFSCVrd 302
Cdd:cd16426    1 LLPGTIIPAVLLTGIDSD-------LPGPVLARVTRDVYDPNGGRlLIPKGSRLIGEYYGDLSSqERVLVRWTRLICP-- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 303 DGGVIEAKlDSYAVGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGvseafdvnpvpvvstnpgsntqyqsvfsdqmlqga 382
Cdd:cd16426   72 DGVSIDLD-SVAGADALGRAGLRGDVDNHFGERFGGALLASLLSG----------------------------------- 115

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 582041999 383 avkgaskaldRIAQFYIDMAEGIFPVIEVDAGRQVDIIVTKGTKL 427
Cdd:cd16426  116 ----------QLAQQYLQRAENIPPTITVNAGTRVNIVVARDVDL 150
VirB10 cd16429
VirB10 forms part of core complex in Type IV secretion system (T4SS); This family contains ...
 300-423 1.45e-05

VirB10 forms part of core complex in Type IV secretion system (T4SS); This family contains VirB10, a component of the type IV secretion system (T4SS), including homologs TrbI, TraF, TrwE and TraL. T4S system is employed by pathogenic bacteria to export virulence DNAs and/or proteins directly from the bacterial cytoplasm into the host cell. It forms a large multiprotein complex consisting of 12 proteins termed VirB1-11 and VirD4. VirB10, interacts with VirB7 and VirB9, forming the membrane-spanning 'core complex' (CC), around which all other components assemble. The CC is inserted in both, the outer and inner membranes, playing a fundamental role as a scaffold for the rest of the T4SS components and actively participating in T4S substrate transfer through the bacterial envelope via conformational changes regulating channel opening and closing. TrwE in R33 plasmid has been shown to be anchored to the inner membrane and its C-terminal is necessary for conjugation; the transmembrane domains of TrwB and TrwE are involved in TrwB-TrwE interactions. TraF protein of the RP4 plasmid is involved in circularization of pilin subunits of P-type pili. In gonococcal genetic island (GGI) of Neisseria gonorrhoeae, T4SS encodes TrbI and circularization occurs via a covalent intermediate between the C terminus of putative pilin protein TraA and TrbI.


Pssm-ID: 319755  Cd Length: 180  Bit Score: 45.18  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999 300 VRDDGGVIEakLDS-YAVGEDGKAGVRGRVVSKQGQIIAKSLMAGFLGGVSEAfdvnpvpvVSTNPGSNTQYQSVFSDQM 378
Cdd:cd16429   70 ITPDGVSID--LDSmPGADALGRAGLKGDVDNHFWERFGGALLLSLISDGAQA--------ASSSASNSNSAGQAAGSNT 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 582041999 379 LQGAAvKGASKALDRiaqfYIDmaegIFPVIEVDAGRQVDIIVTK 423
Cdd:cd16429  140 GQSLG-QVASQILER----NLN----IPPTITIRQGTRINIFVAR 175
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 37-130 4.67e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.23  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 582041999   37 KKEEKrgrqeTIKHVLTDKNTReigIDSLSAD-VKMVSRENSD------LKKELERVKKELEETKTTAGKSSDvgrEMTR 109
Cdd:TIGR04523  81 EQQIK-----DLNDKLKKNKDK---INKLNSDlSKINSEIKNDkeqknkLEVELNKLEKQKKENKKNIDKFLT---EIKK 149

                          90       100
                  ....*....|....*....|.
gi 582041999  110 LRQDLDRLTQKNMELAKKVET 130
Cdd:TIGR04523 150 KEKELEKLNNKYNDLKKQKEE 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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