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Conserved domains on  [gi|578835013|ref|XP_006723491|]
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transcriptional enhancer factor TEF-4 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YBD super family cl39255
YAP binding domain; TEA domain transcription factors contain an N-terminal TEA domain ...
227-431 3.52e-59

YAP binding domain; TEA domain transcription factors contain an N-terminal TEA domain pfam01285 and a C-terminal YAP binding domain (YBD). This entry corresponds to the YBD that binds to the oncoproteins YAP and TAZ. The structure of the YBD shows that it has an Ig-like beta sandwich fold.


The actual alignment was detected with superfamily member pfam17725:

Pssm-ID: 435993  Cd Length: 202  Bit Score: 192.31  E-value: 3.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835013  227 RLQLVEFSAFVEPPDAVdsyQRHLFVHISQHcpspGAPPLESVDVRQIYDKFPEKkggLRELYDRGPPHAFFLVKFWADL 306
Cdd:pfam17725   2 RLALDGFSAYVDYPMTA---GRHDFVEITGF----ADPPLECIDLSQIADKFPRE---LRELFLAGPPDAFFLVKCWANL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835013  307 NWGPSGEEAGAGGsissggFYGVSSQYESLEHMTLTCSSKT--------ERAQL-----EDGRFVYRLLRSPMCEYLVNF 373
Cdd:pfam17725  72 NFDLPDDNTNGRA------IYAVDSRYESLERFDVEVSTKAisfgkqavEKIEVyepieDGGRYVFALNSSPMCEYMVKF 145
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578835013  374 LHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAqHHIYRL 431
Cdd:pfam17725 146 IAELKKLNGIDLMNKVLENFTVLQVVRNQETGEVLMSIAFVFEVSPPPEPT-CHVYRL 202
TEA smart00426
TEA domain;
40-107 5.51e-43

TEA domain;


:

Pssm-ID: 128703  Cd Length: 68  Bit Score: 145.48  E-value: 5.51e-43
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578835013    40 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 107
Cdd:smart00426   1 DAEGVWSPDIEQAFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 68
 
Name Accession Description Interval E-value
YBD pfam17725
YAP binding domain; TEA domain transcription factors contain an N-terminal TEA domain ...
227-431 3.52e-59

YAP binding domain; TEA domain transcription factors contain an N-terminal TEA domain pfam01285 and a C-terminal YAP binding domain (YBD). This entry corresponds to the YBD that binds to the oncoproteins YAP and TAZ. The structure of the YBD shows that it has an Ig-like beta sandwich fold.


Pssm-ID: 435993  Cd Length: 202  Bit Score: 192.31  E-value: 3.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835013  227 RLQLVEFSAFVEPPDAVdsyQRHLFVHISQHcpspGAPPLESVDVRQIYDKFPEKkggLRELYDRGPPHAFFLVKFWADL 306
Cdd:pfam17725   2 RLALDGFSAYVDYPMTA---GRHDFVEITGF----ADPPLECIDLSQIADKFPRE---LRELFLAGPPDAFFLVKCWANL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835013  307 NWGPSGEEAGAGGsissggFYGVSSQYESLEHMTLTCSSKT--------ERAQL-----EDGRFVYRLLRSPMCEYLVNF 373
Cdd:pfam17725  72 NFDLPDDNTNGRA------IYAVDSRYESLERFDVEVSTKAisfgkqavEKIEVyepieDGGRYVFALNSSPMCEYMVKF 145
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578835013  374 LHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAqHHIYRL 431
Cdd:pfam17725 146 IAELKKLNGIDLMNKVLENFTVLQVVRNQETGEVLMSIAFVFEVSPPPEPT-CHVYRL 202
TEA smart00426
TEA domain;
40-107 5.51e-43

TEA domain;


Pssm-ID: 128703  Cd Length: 68  Bit Score: 145.48  E-value: 5.51e-43
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578835013    40 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 107
Cdd:smart00426   1 DAEGVWSPDIEQAFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 68
TEA pfam01285
TEA/ATTS domain;
42-107 3.37e-32

TEA/ATTS domain;


Pssm-ID: 426180  Cd Length: 68  Bit Score: 116.54  E-value: 3.37e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578835013   42 EGVWSPDIEQSFQEALAIYPPCGRRKIilSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 107
Cdd:pfam01285   2 EAVWPPDLEAAFLEALRAYPPMGRRKI--KINGRFPGRNELISDYILRKTGKERTRKQVSSHIQVL 65
 
Name Accession Description Interval E-value
YBD pfam17725
YAP binding domain; TEA domain transcription factors contain an N-terminal TEA domain ...
227-431 3.52e-59

YAP binding domain; TEA domain transcription factors contain an N-terminal TEA domain pfam01285 and a C-terminal YAP binding domain (YBD). This entry corresponds to the YBD that binds to the oncoproteins YAP and TAZ. The structure of the YBD shows that it has an Ig-like beta sandwich fold.


Pssm-ID: 435993  Cd Length: 202  Bit Score: 192.31  E-value: 3.52e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835013  227 RLQLVEFSAFVEPPDAVdsyQRHLFVHISQHcpspGAPPLESVDVRQIYDKFPEKkggLRELYDRGPPHAFFLVKFWADL 306
Cdd:pfam17725   2 RLALDGFSAYVDYPMTA---GRHDFVEITGF----ADPPLECIDLSQIADKFPRE---LRELFLAGPPDAFFLVKCWANL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835013  307 NWGPSGEEAGAGGsissggFYGVSSQYESLEHMTLTCSSKT--------ERAQL-----EDGRFVYRLLRSPMCEYLVNF 373
Cdd:pfam17725  72 NFDLPDDNTNGRA------IYAVDSRYESLERFDVEVSTKAisfgkqavEKIEVyepieDGGRYVFALNSSPMCEYMVKF 145
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578835013  374 LHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAqHHIYRL 431
Cdd:pfam17725 146 IAELKKLNGIDLMNKVLENFTVLQVVRNQETGEVLMSIAFVFEVSPPPEPT-CHVYRL 202
TEA smart00426
TEA domain;
40-107 5.51e-43

TEA domain;


Pssm-ID: 128703  Cd Length: 68  Bit Score: 145.48  E-value: 5.51e-43
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578835013    40 DAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 107
Cdd:smart00426   1 DAEGVWSPDIEQAFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 68
TEA pfam01285
TEA/ATTS domain;
42-107 3.37e-32

TEA/ATTS domain;


Pssm-ID: 426180  Cd Length: 68  Bit Score: 116.54  E-value: 3.37e-32
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578835013   42 EGVWSPDIEQSFQEALAIYPPCGRRKIilSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVL 107
Cdd:pfam01285   2 EAVWPPDLEAAFLEALRAYPPMGRRKI--KINGRFPGRNELISDYILRKTGKERTRKQVSSHIQVL 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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