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Conserved domains on  [gi|578824325|ref|XP_006719702|]
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2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial isoform X1 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10011316)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0032259|GO:1904047
PubMed:  9045837|12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-246 2.98e-113

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


:

Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 324.41  E-value: 2.98e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneeds 80
Cdd:PRK00216  27 MNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKT------------------------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  81 lggSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:PRK00216  77 ---GEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325 161 FLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAI 240
Cdd:PRK00216 154 LVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVAL 233


                 ....*.
gi 578824325 241 HSGFKL 246
Cdd:PRK00216 234 HVGYKP 239
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-246 2.98e-113

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 324.41  E-value: 2.98e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneeds 80
Cdd:PRK00216  27 MNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKT------------------------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  81 lggSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:PRK00216  77 ---GEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325 161 FLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAI 240
Cdd:PRK00216 154 LVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVAL 233


                 ....*.
gi 578824325 241 HSGFKL 246
Cdd:PRK00216 234 HVGYKP 239
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
1-245 8.37e-93

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 272.39  E-value: 8.37e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325    1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneeds 80
Cdd:pfam01209  18 MNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSS------------------------------ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   81 lggSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:pfam01209  68 ---GKVVGLDINENMLKEGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGR 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  161 FLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAI 240
Cdd:pfam01209 144 VVCLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAI 223


                  ....*
gi 578824325  241 HSGFK 245
Cdd:pfam01209 224 HWGIK 228
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 1-245 1.29e-90

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 266.44  E-value: 1.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325    1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrKQKRQLRAQqnlsweeiakeyqneeds 80
Cdd:TIGR01934  15 LNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIEL----------AKSAPDRGK------------------ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   81 lggsrVVVCDINKEMLKVGKQKALAQgyrAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:TIGR01934  67 -----VTGVDFSSEMLEVAKKKSELP---LNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGR 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  161 FLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAI 240
Cdd:TIGR01934 139 LVILEFSKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAI 218


                  ....*
gi 578824325  241 HSGFK 245
Cdd:TIGR01934 219 HVGKK 223
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 14-177 1.33e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 113.17  E-value: 1.33e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  14 KDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqqnlsweeiakeyqneedslgGSRVVVCDINK 93
Cdd:COG2226   11 REALLAALGLRPGARVLDLGCGTGRLALALAER------------------------------------GARVTGVDISP 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  94 EMLKVGKQKALAQGYRagLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPL 173
Cdd:COG2226   55 EMLELARERAAEAGLN--VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAE 132


                 ....
gi 578824325 174 ISRL 177
Cdd:COG2226  133 LEEL 136
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-163 1.95e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 64.37  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  80 SLGGSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFD-DDKFD-IYTIAFGIRNVTHIDQALQEAHRVLKP 157
Cdd:cd02440   18 SGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELPPEaDESFDvIISDPPLHHLVEDLARFLEEARRLLKP 96


                 ....*.
gi 578824325 158 GGRFLC 163
Cdd:cd02440   97 GGVLVL 102
 
Name Accession Description Interval E-value
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-246 2.98e-113

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 324.41  E-value: 2.98e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneeds 80
Cdd:PRK00216  27 MNDLLSFGLHRVWRRKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKT------------------------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  81 lggSRVVVCDINKEMLKVGKQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:PRK00216  77 ---GEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325 161 FLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAI 240
Cdd:PRK00216 154 LVILEFSKPTNPPLKKAYDFYLFKVLPLIGKLISKNAEAYSYLAESIRAFPDQEELAAMLEEAGFERVRYRNLTGGIVAL 233


                 ....*.
gi 578824325 241 HSGFKL 246
Cdd:PRK00216 234 HVGYKP 239
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
1-245 8.37e-93

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 272.39  E-value: 8.37e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325    1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneeds 80
Cdd:pfam01209  18 MNDVISFGIHRLWKDFTMKCMGVKRGNKFLDVAGGTGDWTFGLSDSAGSS------------------------------ 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   81 lggSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:pfam01209  68 ---GKVVGLDINENMLKEGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGR 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  161 FLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAI 240
Cdd:pfam01209 144 VVCLEFSKPENPLLSQAYELYFKYVMPFMGKMFAKSYKSYQYLQESIRDFPDQKTLASMFEKAGFKSVGYESLTGGIAAI 223


                  ....*
gi 578824325  241 HSGFK 245
Cdd:pfam01209 224 HWGIK 228
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 1-245 1.29e-90

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 266.44  E-value: 1.29e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325    1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrKQKRQLRAQqnlsweeiakeyqneeds 80
Cdd:TIGR01934  15 LNDLLSFGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIEL----------AKSAPDRGK------------------ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   81 lggsrVVVCDINKEMLKVGKQKALAQgyrAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:TIGR01934  67 -----VTGVDFSSEMLEVAKKKSELP---LNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGR 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  161 FLCLEFSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVAI 240
Cdd:TIGR01934 139 LVILEFSKPANALLKKFYKFYLKNVLPSIGGLISKNAEAYTYLPESIRAFPSQEELAAMLKEAGFEEVRYRSLTFGVAAI 218


                  ....*
gi 578824325  241 HSGFK 245
Cdd:TIGR01934 219 HVGKK 223
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 14-177 1.33e-31

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 113.17  E-value: 1.33e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  14 KDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqqnlsweeiakeyqneedslgGSRVVVCDINK 93
Cdd:COG2226   11 REALLAALGLRPGARVLDLGCGTGRLALALAER------------------------------------GARVTGVDISP 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  94 EMLKVGKQKALAQGYRagLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQVNNPL 173
Cdd:COG2226   55 EMLELARERAAEAGLN--VEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAE 132


                 ....
gi 578824325 174 ISRL 177
Cdd:COG2226  133 LEEL 136
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 1-238 4.26e-28

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 107.67  E-value: 4.26e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   1 MNDMMSLGIHRVWKDLLLWKMHPLPGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneeds 80
Cdd:PLN02233  49 LNDLLSLGQHRIWKRMAVSWSGAKMGDRVLDLCCGSGDLAFLLSEKVGSD------------------------------ 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  81 lggSRVVVCDINKEMLKVG--KQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPG 158
Cdd:PLN02233  99 ---GKVMGLDFSSEQLAVAasRQELKAKSCYKNIEWIEGDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPG 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325 159 GRFLCLEFSQVNNPLISRLYD-LYSFQVIPVlgEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGI 237
Cdd:PLN02233 176 SRVSILDFNKSTQPFTTSMQEwMIDNVVVPV--ATGYGLAKEYEYLKSSINEYLTGEELEKLALEAGFSSAKHYEISGGL 253


                 .
gi 578824325 238 V 238
Cdd:PLN02233 254 M 254
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 30-159 1.64e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 85.69  E-value: 1.64e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   30 LDVAGGTGDIAFRFLNyvqsqhqrkqkrqlraqqnlsweeiakeyqneedsLGGSRVVVCDINKEMLKVGKQKALAQGYR 109
Cdd:pfam13649   2 LDLGCGTGRLTLALAR-----------------------------------RGGARVTGVDLSPEMLERARERAAEAGLN 46

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 578824325  110 AglAWVLGDAEELPFDDDKFDIYTIAFGIRNVTH--IDQALQEAHRVLKPGG 159
Cdd:pfam13649  47 V--EFVQGDAEDLPFPDGSFDLVVSSGVLHHLPDpdLEAALREIARVLKPGG 96
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 83-163 2.55e-20

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 82.33  E-value: 2.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   83 GSRVVVCDINKEMLKVGKQKAlaqgYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFL 162
Cdd:pfam08241  18 GARVTGVDISPEMLELAREKA----PREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILI 93


                  .
gi 578824325  163 C 163
Cdd:pfam08241  94 I 94
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 90-239 4.30e-19

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 81.27  E-value: 4.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  90 DINKEMLKVG--KQKALAQGYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFS 167
Cdd:PLN02232   4 DFSSEQLAVAatRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSILDFN 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578824325 168 QVNNPLISRLYD-LYSFQVIPVlgEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVTYESLTSGIVA 239
Cdd:PLN02232  84 KSNQSVTTFMQGwMIDNVVVPV--ATVYDLAKEYEYLKYSINGYLTGEELETLALEAGFSSACHYEISGGFMG 154
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 4-162 4.73e-15

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 69.28  E-value: 4.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   4 MMSLGIHRVWKDLL--LWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrkqkrqlrAQQnlsweeiakeyqneedsl 81
Cdd:COG2227    1 MSDPDARDFWDRRLaaLLARLLPAGGRVLDVGCGTGRLALAL-----------------ARR------------------ 45

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  82 gGSRVVVCDINKEMLKVGKQKALaqgyRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRF 161
Cdd:COG2227   46 -GADVTGVDISPEALEIARERAA----ELNVDFVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLL 120


                 .
gi 578824325 162 L 162
Cdd:COG2227  121 L 121
PRK08317 PRK08317
hypothetical protein; Provisional
 21-166 1.88e-14

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 70.35  E-value: 1.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  21 MHPLPGTQLLDVAGGTGDIAFrflnyvqsqhqrkqkrqlraqqnlsweEIAKEYQNEedslggSRVVVCDINKEMLKVGK 100
Cdd:PRK08317  15 LAVQPGDRVLDVGCGPGNDAR---------------------------ELARRVGPE------GRVVGIDRSEAMLALAK 61

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578824325 101 QKALAQGYRAglAWVLGDAEELPFDDDKFDIytiAFGIRNVTHI---DQALQEAHRVLKPGGRFLCLEF 166
Cdd:PRK08317  62 ERAAGLGPNV--EFVRGDADGLPFPDGSFDA---VRSDRVLQHLedpARALAEIARVLRPGGRVVVLDT 125
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 80-163 1.95e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 64.37  E-value: 1.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  80 SLGGSRVVVCDINKEMLKVGKQKALAQGYRaGLAWVLGDAEELPFD-DDKFD-IYTIAFGIRNVTHIDQALQEAHRVLKP 157
Cdd:cd02440   18 SGPGARVTGVDISPVALELARKAAAALLAD-NVEVLKGDAEELPPEaDESFDvIISDPPLHHLVEDLARFLEEARRLLKP 96


                 ....*.
gi 578824325 158 GGRFLC 163
Cdd:cd02440   97 GGVLVL 102
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 15-162 9.45e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 61.10  E-value: 9.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  15 DLLLWKMHPLPGTQLLDVAGGTGDIAFRFlnyvqsqhqrkqkrqlraqqnlsweeiAKEYqneedslgGSRVVVCDINKE 94
Cdd:COG2230   41 DLILRKLGLKPGMRVLDIGCGWGGLALYL---------------------------ARRY--------GVRVTGVTLSPE 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578824325  95 MLKVGKQKALAQGYRAGLAWVLGDAEELPFdDDKFD-IYTI----AFGIRNvthIDQALQEAHRVLKPGGRFL 162
Cdd:COG2230   86 QLEYARERAAEAGLADRVEVRLADYRDLPA-DGQFDaIVSIgmfeHVGPEN---YPAYFAKVARLLKPGGRLL 154
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 25-167 5.43e-11

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 58.97  E-value: 5.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   25 PGTQLLDVAGGTGDIAFRFLNYVQSQhqrkqkrqlraqqnlsweeiakeyqneedslggSRVVVCDINKEMLKVGKQKAL 104
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEELGPN---------------------------------AEVVGIDISEEAIEKARENAQ 49

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578824325  105 AQGYrAGLAWVLGDAEELP--FDDDKFDIyTIAFGIRN-VTHIDQALQEAHRVLKPGGRFLCLEFS 167
Cdd:pfam13847  50 KLGF-DNVEFEQGDIEELPelLEDDKFDV-VISNCVLNhIPDPDKVLQEILRVLKPGGRLIISDPD 113
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 30-161 1.84e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 53.53  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   30 LDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqqnlsweeiakeyqneedsLGGSRVVVCDINKEMLKVGKQKALAQGYR 109
Cdd:pfam08242   1 LEIGCGTGTLLRALLEA----------------------------------LPGLEYTGLDISPAALEAARERLAALGLL 46

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 578824325  110 AGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRF 161
Cdd:pfam08242  47 NAVRVELFQLDLGELDPGSFDVVVASNVLHHLADPRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 81-162 4.38e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 54.54  E-value: 4.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  81 LGGSRVVVCDINKEMLKVGKQKALAQGYrAGLAWVLGDAEEL-PFDDDKFDiYTIAFGIrnVTHID-----QALQEAHRV 154
Cdd:COG0500   47 RFGGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLAELdPLPAESFD-LVVAFGV--LHHLPpeereALLRELARA 122


                 ....*...
gi 578824325 155 LKPGGRFL 162
Cdd:COG0500  123 LKPGGVLL 130
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 90-216 3.28e-08

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 52.67  E-value: 3.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325   90 DINKEMLKVGKQKalaqgYRAGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLEFSQV 169
Cdd:TIGR02072  65 DISAGMLAQAKTK-----LSENVQFICGDAEKLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAFSTFGPG 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 578824325  170 NNPLISRLYDLYSFQVIPV--LGEVIAGDWKSYQYLVESIR-RFPSQEEF 216
Cdd:TIGR02072 140 TLHELRQSFGQHGLRYLSLdeLKALLKNSFELLTLEEELITlSFDDPLDV 189
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 81-160 1.03e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 50.33  E-value: 1.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  81 LGGSRVVVCDINKEMLKvgkqkalaqGYRAGLAW--------VLGDAEELPFDDDKFDI------YTIAFGI--RNVTHI 144
Cdd:COG1041   46 LLGRRVIGSDIDPKMVE---------GARENLEHygyedadvIRGDARDLPLADESVDAivtdppYGRSSKIsgEELLEL 116

                         90
                 ....*....|....*..
gi 578824325 145 -DQALQEAHRVLKPGGR 160
Cdd:COG1041  117 yEKALEEAARVLKPGGR 133
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
25-162 3.21e-07

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 47.13  E-value: 3.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  25 PGTQLLDVAGGTGDIAfrflnyvqsqhqrkqkRQLRAQqnlsweeiakeyqneedsLGGSRVVVCDINKEMLkvgkqkAL 104
Cdd:COG4106    1 PPRRVLDLGCGTGRLT----------------ALLAER------------------FPGARVTGVDLSPEML------AR 40

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578824325 105 AQGYRAGLAWVLGDAEELPFDDdKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFL 162
Cdd:COG4106   41 ARARLPNVRFVVADLRDLDPPE-PFDLVVSNAALHWLPDHAALLARLAAALAPGGVLA 97
arsM PRK11873
arsenite methyltransferase;
90-232 3.81e-07

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 49.95  E-value: 3.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  90 DINKEMLKVGKQKALAQGYrAGLAWVLGDAEELPFDDDKFDIYtiafgIRN-----VTHIDQALQEAHRVLKPGGRFlcl 164
Cdd:PRK11873 109 DMTPEMLAKARANARKAGY-TNVEFRLGEIEALPVADNSVDVI-----ISNcvinlSPDKERVFKEAFRVLKPGGRF--- 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578824325 165 efsqvnnpLISrlyDLysfqvipvlgeVIAGDwksyqyLVESIRRFP-----------SQEEFKDMIEDAGFHKVTYES 232
Cdd:PRK11873 180 --------AIS---DV-----------VLRGE------LPEEIRNDAelyagcvagalQEEEYLAMLAEAGFVDITIQP 230
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 86-228 4.63e-07

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 49.89  E-value: 4.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  86 VVVCDINKEMLKVGKQKALAQGYRAglawVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRfLCLe 165
Cdd:PLN02490 140 VTILDQSPHQLAKAKQKEPLKECKI----IEGDAEDLPFPTDYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGGK-ACL- 213

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578824325 166 fsqvnnplisrlydlysfqvipvLGEVIAGDWKSyQYLVESIRRFPSQEEFKDMIEDAGFHKV 228
Cdd:PLN02490 214 -----------------------IGPVHPTFWLS-RFFADVWMLFPKEEEYIEWFTKAGFKDV 252
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 83-160 1.67e-06

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 47.83  E-value: 1.67e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578824325  83 GSRVVVCDINKEMLKVGKQKALAQGYraglawVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGR 160
Cdd:PRK10258  64 GSQVTALDLSPPMLAQARQKDAADHY------LAGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPGGV 135
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
11-162 4.72e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.76  E-value: 4.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  11 RVWKDL---LLWKMHPLPGTQLLDVAGGTGDIAFRFLNYvqsqhqrkqkrqlraqqnlsweeiakeyqneedslgGSRVV 87
Cdd:COG4976   29 EAPALLaeeLLARLPPGPFGRVLDLGCGTGLLGEALRPR------------------------------------GYRLT 72

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578824325  88 VCDINKEMLKVGKQKALaqgyraGLAWVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFL 162
Cdd:COG4976   73 GVDLSEEMLAKAREKGV------YDRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFI 141
PRK05785 PRK05785
hypothetical protein; Provisional
 86-245 2.53e-04

hypothetical protein; Provisional


Pssm-ID: 235607 [Multi-domain]  Cd Length: 226  Bit Score: 41.21  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325  86 VVVCDINKEMLKVgkqkALAQGYRaglawVLGDAEELPFDDDKFDIYTIAFGIRNVTHIDQALQEAHRVLKPGGRFLCLe 165
Cdd:PRK05785  77 VVALDYAENMLKM----NLVADDK-----VVGSFEALPFRDKSFDVVMSSFALHASDNIEKVIAEFTRVSRKQVGFIAM- 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824325 166 fSQVNNPLISRLYDLYSFQVIPVLGEVIAGDWKSYQYLVESIRRFPSQEEFKDMIEDAGFHKVtYESLTSGIVAIHSGFK 245
Cdd:PRK05785 147 -GKPDNVIKRKYLSFYLRYIMPYIACLAGAKCRDYKYIYYIYERLPTNSFHREIFEKYADIKV-YEERGLGLVYFVVGSS 224
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
115-163 6.82e-04

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 39.08  E-value: 6.82e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578824325 115 VLGDAEE-LPFDDDKFD-IYTiafgiRNV-THIDQ-----ALQEAHRVLKPGGRFLC 163
Cdd:COG4627   32 IVGDLTDpLPFPDNSVDaIYS-----SHVlEHLDYeeaplALKECYRVLKPGGILRI 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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