DNA/RNA-binding protein KIN17 isoform X2 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Kin17_mid super family | cl11024 | Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ... |
1-71 | 1.14e-38 | ||
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle. The actual alignment was detected with superfamily member pfam10357: Pssm-ID: 463057 Cd Length: 123 Bit Score: 132.22 E-value: 1.14e-38
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| KN17_SH3 | pfam18131 | KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ... |
170-222 | 1.12e-21 | ||
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution. : Pssm-ID: 407963 Cd Length: 53 Bit Score: 85.48 E-value: 1.12e-21
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| KOW super family | cl00354 | KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ... |
233-267 | 1.71e-12 | ||
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues. The actual alignment was detected with superfamily member cd13155: Pssm-ID: 469738 Cd Length: 54 Bit Score: 61.01 E-value: 1.71e-12
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| Name | Accession | Description | Interval | E-value | ||
| Kin17_mid | pfam10357 | Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ... |
1-71 | 1.14e-38 | ||
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle. Pssm-ID: 463057 Cd Length: 123 Bit Score: 132.22 E-value: 1.14e-38
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| KN17_SH3 | pfam18131 | KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ... |
170-222 | 1.12e-21 | ||
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution. Pssm-ID: 407963 Cd Length: 53 Bit Score: 85.48 E-value: 1.12e-21
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| KOW_KIN17 | cd13155 | KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ... |
233-267 | 1.71e-12 | ||
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control. Pssm-ID: 240519 Cd Length: 54 Bit Score: 61.01 E-value: 1.71e-12
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| Name | Accession | Description | Interval | E-value | ||
| Kin17_mid | pfam10357 | Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue ... |
1-71 | 1.14e-38 | ||
Domain of Kin17 curved DNA-binding protein; Kin17_mid is the conserved central 169 residue region of a family of Kin17 proteins. Towards the N-terminal end there is a zinc-finger domain, and in human and mouse members there is a RecA-like domain further downstream. The Kin17 protein in humans forms intra-nuclear foci during cell proliferation and is re-distributed in the nucleoplasm during the cell cycle. Pssm-ID: 463057 Cd Length: 123 Bit Score: 132.22 E-value: 1.14e-38
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| KN17_SH3 | pfam18131 | KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 ... |
170-222 | 1.12e-21 | ||
KN17 SH3-like C-terminal domain; This domain can be found at the C terminus of the human KIN17 protein and its homologs. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution. Pssm-ID: 407963 Cd Length: 53 Bit Score: 85.48 E-value: 1.12e-21
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| KOW_KIN17 | cd13155 | KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the ... |
233-267 | 1.71e-12 | ||
KOW_Kin17 is a RNA-binding motif; KOW domain of the KIN17protein contributes to the RNA-binding properties of the whole protein. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KIN17 is conserved from yeast to human that ubiquitously expressed at low levels in mammals tissue and have functions in DNA replication, DNA repair and cell cycle control. Pssm-ID: 240519 Cd Length: 54 Bit Score: 61.01 E-value: 1.71e-12
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| KOW | cd00380 | KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ... |
234-270 | 2.13e-05 | ||
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues. Pssm-ID: 240504 Cd Length: 49 Bit Score: 41.05 E-value: 2.13e-05
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| Blast search parameters | ||||
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