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Conserved domains on  [gi|578812403|ref|XP_006715403|]
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nuclear receptor coactivator 7 isoform X1 [Homo sapiens]

Protein Classification

LysM peptidoglycan-binding domain-containing protein( domain architecture ID 10478509)

LysM peptidoglycan-binding domain-containing protein may bind N-acetylglucosamine in carbohydrates such as chitin, chitio-oligosaccharides and peptidoglycan

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
780-942 6.05e-50

domain in TBC and LysM domain containing proteins;


:

Pssm-ID: 214733  Cd Length: 165  Bit Score: 173.66  E-value: 6.05e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403   780 SALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYG 859
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403   860 TGETFLYTFSPHFKVFKWSGEN-SYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKK-EDFIVQDLE 937
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNkYYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLSTKqEDFLILDIE 160

                   ....*
gi 578812403   938 VWAFD 942
Cdd:smart00584 161 VWGFG 165
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
11-158 5.91e-11

LysM repeat [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 61.65  E-value: 5.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403  11 KQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRYYSi 90
Cdd:COG1388   10 AALLAAVLTLLAALLLLAAALAAVALLLLAALAPAGLSLAAALNGEALLLLLPAAAAAAKAALAAAPEAAAAAAARYTV- 88
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578812403  91 ddNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 158
Cdd:COG1388   89 --KSGDTLSGIARRYGAAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIP 154
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
780-942 6.05e-50

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 173.66  E-value: 6.05e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403   780 SALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYG 859
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403   860 TGETFLYTFSPHFKVFKWSGEN-SYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKK-EDFIVQDLE 937
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNkYYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLSTKqEDFLILDIE 160

                   ....*
gi 578812403   938 VWAFD 942
Cdd:smart00584 161 VWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
806-941 3.19e-35

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 130.81  E-value: 3.19e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403  806 LAYSTLEHGTSLKTLYRKSASlDSPVLLVIKDMDNQIFGAYATHPFKFSDH-YYGTGETFLYTFSPHFKVFKWSGENSYF 884
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDN-KGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAY 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578812403  885 INGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSK--KEDFIVQDLEVWAF 941
Cdd:pfam07534  80 FNCTSDGLGFGGGQPKFDLWIDSDLEFGYSRHCETFGNGQLSGsgQERFKIDDVEVWGL 138
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
795-939 1.46e-20

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 91.11  E-value: 1.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403 795 LPARVQGY-PWRLAYSTLEHGTSLKTLYRKSASLDSPV-----LLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTF 868
Cdd:COG5142   49 LPDRYKYStSWRLLYSLFENGFSLRTFYESFGENEWPFrrvgfVLACRDKDGDLFGAFFEDRIRPARHYYGRDEMFLWKA 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403 869 SP---------HFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFI-VQDLEV 938
Cdd:COG5142  129 ARrpadrladkEVAVYPISGGKGFGIYCTPDFLAFGCGGGRYGLLIDKSLLDGESHPVETFGNCLLSSKGHFFrIVYLEL 208

                 .
gi 578812403 939 W 939
Cdd:COG5142  209 W 209
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
11-158 5.91e-11

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 61.65  E-value: 5.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403  11 KQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRYYSi 90
Cdd:COG1388   10 AALLAAVLTLLAALLLLAAALAAVALLLLAALAPAGLSLAAALNGEALLLLLPAAAAAAKAALAAAPEAAAAAAARYTV- 88
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578812403  91 ddNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 158
Cdd:COG1388   89 --KSGDTLSGIARRYGAAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIP 154
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
122-158 2.07e-08

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 50.86  E-value: 2.07e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578812403  122 DTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 158
Cdd:pfam01476   7 DTLSSIAKRYGITVEQLAELNGLSSPNLYVGQKLKIP 43
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
116-157 1.87e-06

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 45.55  E-value: 1.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 578812403 116 YTAGNQDTLNSIALKFNITPNKLVELNKLFT-HTIVPGQVLFV 157
Cdd:cd00118    3 YTVKPGDTLWSIAKKYGVTVEELAAANPLINpDCIYPGQKLKI 45
LysM smart00257
Lysin motif;
122-157 4.46e-06

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 44.36  E-value: 4.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 578812403   122 DTLNSIALKFNITPNKLVELNKLF-THTIVPGQVLFV 157
Cdd:smart00257   8 DTLSSIARRYGISVSDLLELNNILdPDNLQVGQKLKI 44
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
116-157 8.76e-03

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 39.72  E-value: 8.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 578812403 116 YTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFV 157
Cdd:PRK10783 346 YKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTI 387
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
780-942 6.05e-50

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 173.66  E-value: 6.05e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403   780 SALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYG 859
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGYRPPTLLIIKDTDGEVFGAYASQAWRVSDHFYG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403   860 TGETFLYTFSPHFKVFKWSGEN-SYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKK-EDFIVQDLE 937
Cdd:smart00584  81 TGESFLFQLNPKFVVYDWTGKNkYYYINGTPDSLPIGGGGGGFGLWIDEDLNHGSSSHCKTFGNPPLSTKqEDFLILDIE 160

                   ....*
gi 578812403   938 VWAFD 942
Cdd:smart00584 161 VWGFG 165
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
806-941 3.19e-35

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 429519  Cd Length: 139  Bit Score: 130.81  E-value: 3.19e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403  806 LAYSTLEHGTSLKTLYRKSASlDSPVLLVIKDMDNQIFGAYATHPFKFSDH-YYGTGETFLYTFSPHFKVFKWSGENSYF 884
Cdd:pfam07534   1 LLYSTSRDGSSYQTFLEKIDN-KGPTLLIIKDNDGYIFGAFASQPWKVSGKkFYGDGESFLFSLSPQFDPYKWTGKNNAY 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578812403  885 INGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSK--KEDFIVQDLEVWAF 941
Cdd:pfam07534  80 FNCTSDGLGFGGGQPKFDLWIDSDLEFGYSRHCETFGNGQLSGsgQERFKIDDVEVWGL 138
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
795-939 1.46e-20

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 91.11  E-value: 1.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403 795 LPARVQGY-PWRLAYSTLEHGTSLKTLYRKSASLDSPV-----LLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTF 868
Cdd:COG5142   49 LPDRYKYStSWRLLYSLFENGFSLRTFYESFGENEWPFrrvgfVLACRDKDGDLFGAFFEDRIRPARHYYGRDEMFLWKA 128
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403 869 SP---------HFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFI-VQDLEV 938
Cdd:COG5142  129 ARrpadrladkEVAVYPISGGKGFGIYCTPDFLAFGCGGGRYGLLIDKSLLDGESHPVETFGNCLLSSKGHFFrIVYLEL 208

                 .
gi 578812403 939 W 939
Cdd:COG5142  209 W 209
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
11-158 5.91e-11

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 61.65  E-value: 5.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812403  11 KQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRYYSi 90
Cdd:COG1388   10 AALLAAVLTLLAALLLLAAALAAVALLLLAALAPAGLSLAAALNGEALLLLLPAAAAAAKAALAAAPEAAAAAAARYTV- 88
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578812403  91 ddNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 158
Cdd:COG1388   89 --KSGDTLSGIARRYGAAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIP 154
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
122-158 2.07e-08

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 50.86  E-value: 2.07e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578812403  122 DTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVP 158
Cdd:pfam01476   7 DTLSSIAKRYGITVEQLAELNGLSSPNLYVGQKLKIP 43
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
116-157 1.87e-06

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 45.55  E-value: 1.87e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 578812403 116 YTAGNQDTLNSIALKFNITPNKLVELNKLFT-HTIVPGQVLFV 157
Cdd:cd00118    3 YTVKPGDTLWSIAKKYGVTVEELAAANPLINpDCIYPGQKLKI 45
LysM smart00257
Lysin motif;
122-157 4.46e-06

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 44.36  E-value: 4.46e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 578812403   122 DTLNSIALKFNITPNKLVELNKLF-THTIVPGQVLFV 157
Cdd:smart00257   8 DTLSSIARRYGISVSDLLELNNILdPDNLQVGQKLKI 44
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
116-157 8.76e-03

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 39.72  E-value: 8.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 578812403 116 YTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFV 157
Cdd:PRK10783 346 YKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTI 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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