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Conserved domains on  [gi|578804963|ref|XP_006712840|]
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A-kinase anchor protein SPHKAP isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP_110 super family cl14906
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
 1622-1722 9.80e-11

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


The actual alignment was detected with superfamily member pfam05716:

Pssm-ID: 449376  Cd Length: 692  Bit Score: 66.87  E-value: 9.80e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804963  1622 PPTGTASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVV 1701
Cdd:pfam05716  587 PPEGCAAPK--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVL 664

                           90       100
                   ....*....|....*....|....*..
gi 578804963  1702 QYCKmhEEQKD------GRLSLFDWLL 1722
Cdd:pfam05716  665 RYEK--ERQLDeavgnvTRLQLLDWLM 689
 
Name Accession Description Interval E-value
AKAP_110 pfam05716
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
 1622-1722 9.80e-11

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 428603  Cd Length: 692  Bit Score: 66.87  E-value: 9.80e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804963  1622 PPTGTASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVV 1701
Cdd:pfam05716  587 PPEGCAAPK--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVL 664

                           90       100
                   ....*....|....*....|....*..
gi 578804963  1702 QYCKmhEEQKD------GRLSLFDWLL 1722
Cdd:pfam05716  665 RYEK--ERQLDeavgnvTRLQLLDWLM 689
AKAP_110 smart00807
A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A ...
 1622-1722 2.92e-09

A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 214827  Cd Length: 851  Bit Score: 61.96  E-value: 2.92e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804963   1622 PPTGTASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVV 1701
Cdd:smart00807  746 PPEGCLGPE--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAKAVEKGYSVGEVLQSVL 823

                            90       100
                    ....*....|....*....|....*..
gi 578804963   1702 QYCKmhEEQKD------GRLSLFDWLL 1722
Cdd:smart00807  824 RYEK--ERQLDeavgnvTRLQLLDWLM 848
 
Name Accession Description Interval E-value
AKAP_110 pfam05716
A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein ...
 1622-1722 9.80e-11

A-kinase anchor protein 110 kDa (AKAP 110); This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 428603  Cd Length: 692  Bit Score: 66.87  E-value: 9.80e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804963  1622 PPTGTASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVV 1701
Cdd:pfam05716  587 PPEGCAAPK--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGRSVGEVLQSVL 664

                           90       100
                   ....*....|....*....|....*..
gi 578804963  1702 QYCKmhEEQKD------GRLSLFDWLL 1722
Cdd:pfam05716  665 RYEK--ERQLDeavgnvTRLQLLDWLM 689
AKAP_110 smart00807
A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A ...
 1622-1722 2.92e-09

A-kinase anchor protein 110 kDa; This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.


Pssm-ID: 214827  Cd Length: 851  Bit Score: 61.96  E-value: 2.92e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804963   1622 PPTGTASPQrsLLVINFDLEPECPDAELRATLQWIAASELGIPTIYFKKSQENRIEKFLDVVQLVHRKSWKVGDIFHAVV 1701
Cdd:smart00807  746 PPEGCLGPE--VIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAKAVEKGYSVGEVLQSVL 823

                            90       100
                    ....*....|....*....|....*..
gi 578804963   1702 QYCKmhEEQKD------GRLSLFDWLL 1722
Cdd:smart00807  824 RYEK--ERQLDeavgnvTRLQLLDWLM 848
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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