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Conserved domains on  [gi|578803721|ref|XP_006712350|]
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transmembrane protein 182 isoform X1 [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10621382)

PMP-22/EMP/MP20 family protein similar to human voltage-dependent calcium channel gamma-1 regulatory subunit that gives rise to L-type calcium currents in skeletal muscle

Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 15-156 2.68e-33

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


:

Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 117.91  E-value: 2.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803721   15 ALGVLLFLVAFGSDYWLLaTEVGRCSGekNIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSkncthaylsPY 94
Cdd:pfam13903   1 ILAFALLLIAFATDYWLV-LDVALTGI--NNYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPN---------PF 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578803721   95 PFMRGEHNSTSYDSAVIYRGFWAVLMLLGVVAVVIASFLIICAAPFASHFLYKAGGGSYIAA 156
Cdd:pfam13903  69 PTFEEEIVSFSVTSLPGLTRFVQAFAILSLVLIVCGVVCGLLALPKQSVFLLLAAGILFLLS 130
 
Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 15-156 2.68e-33

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 117.91  E-value: 2.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803721   15 ALGVLLFLVAFGSDYWLLaTEVGRCSGekNIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSkncthaylsPY 94
Cdd:pfam13903   1 ILAFALLLIAFATDYWLV-LDVALTGI--NNYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPN---------PF 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578803721   95 PFMRGEHNSTSYDSAVIYRGFWAVLMLLGVVAVVIASFLIICAAPFASHFLYKAGGGSYIAA 156
Cdd:pfam13903  69 PTFEEEIVSFSVTSLPGLTRFVQAFAILSLVLIVCGVVCGLLALPKQSVFLLLAAGILFLLS 130
 
Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 15-156 2.68e-33

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 117.91  E-value: 2.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803721   15 ALGVLLFLVAFGSDYWLLaTEVGRCSGekNIENVTFHHEGFFWRCWFNGIVEENDSNIWKFWYTNQPPSkncthaylsPY 94
Cdd:pfam13903   1 ILAFALLLIAFATDYWLV-LDVALTGI--NNYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPN---------PF 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578803721   95 PFMRGEHNSTSYDSAVIYRGFWAVLMLLGVVAVVIASFLIICAAPFASHFLYKAGGGSYIAA 156
Cdd:pfam13903  69 PTFEEEIVSFSVTSLPGLTRFVQAFAILSLVLIVCGVVCGLLALPKQSVFLLLAAGILFLLS 130
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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