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Conserved domains on  [gi|578056063|emb|CDH08838|]
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uncharacterized protein ZBAI_00621 [Zygosaccharomyces bailii ISA1307]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lge1 cd22897
Transcriptional regulatory protein Lge1 and similar proteins; This fungal transcriptional ...
 209-292 5.17e-33

Transcriptional regulatory protein Lge1 and similar proteins; This fungal transcriptional regulatory protein Lge1 is involved in the ubiquitination of histones H2A and H2B, a step that is vital in the regulation of the transcriptional activity of RNA polymerase II. In Saccharomyces cerevisiae, Lge1 (also called large cells protein 1), together with its interacting partner ubiquitin ligase Bre1, recruits Rad6, forming a complex that is required for H2B monoubiquitination, a process that regulates transcription, DNA replication, and DNA damage response and repair, ensuring the structural integrity of the genome. In S. pombe the equivalent protein to LGE1 appears to be small histone ubiquitination factor 1 (Shf1).


:

Pssm-ID: 439378  Cd Length: 82  Bit Score: 116.17  E-value: 5.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578056063 209 KRRVDKNDSPFLYLTdldKSTDDPKELEDIREVFKESDRLDKALEEHNFSLLKNELELGLLATQCEKDTLSVRLTQEKLD 288
Cdd:cd22897    1 ESESKEFNSPWIYLL---KGIKDEKTAEELEKIYKELDSLDKKLEELKLKKLKLELELSLLETQAERDALNVQLTQEKLD 77


                 ....
gi 578056063 289 TFLM 292
Cdd:cd22897   78 ELLL 81
 
Name Accession Description Interval E-value
Lge1 cd22897
Transcriptional regulatory protein Lge1 and similar proteins; This fungal transcriptional ...
 209-292 5.17e-33

Transcriptional regulatory protein Lge1 and similar proteins; This fungal transcriptional regulatory protein Lge1 is involved in the ubiquitination of histones H2A and H2B, a step that is vital in the regulation of the transcriptional activity of RNA polymerase II. In Saccharomyces cerevisiae, Lge1 (also called large cells protein 1), together with its interacting partner ubiquitin ligase Bre1, recruits Rad6, forming a complex that is required for H2B monoubiquitination, a process that regulates transcription, DNA replication, and DNA damage response and repair, ensuring the structural integrity of the genome. In S. pombe the equivalent protein to LGE1 appears to be small histone ubiquitination factor 1 (Shf1).


Pssm-ID: 439378  Cd Length: 82  Bit Score: 116.17  E-value: 5.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578056063 209 KRRVDKNDSPFLYLTdldKSTDDPKELEDIREVFKESDRLDKALEEHNFSLLKNELELGLLATQCEKDTLSVRLTQEKLD 288
Cdd:cd22897    1 ESESKEFNSPWIYLL---KGIKDEKTAEELEKIYKELDSLDKKLEELKLKKLKLELELSLLETQAERDALNVQLTQEKLD 77


                 ....
gi 578056063 289 TFLM 292
Cdd:cd22897   78 ELLL 81
Lge1 pfam11488
Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to ...
 230-291 2.39e-20

Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression.


Pssm-ID: 431907  Cd Length: 64  Bit Score: 82.69  E-value: 2.39e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578056063  230 DDPKELEDIREVFKESDRLDKALEEHNFSLLKNELELGLLATQCEKDTLSVRLTQEKLDTFL 291
Cdd:pfam11488   3 DDESTLKKIESKYKELEQLDKKLCELQLKVLKLELELDLLEEQAERDALNVQLTQEKLDEFL 64
 
Name Accession Description Interval E-value
Lge1 cd22897
Transcriptional regulatory protein Lge1 and similar proteins; This fungal transcriptional ...
 209-292 5.17e-33

Transcriptional regulatory protein Lge1 and similar proteins; This fungal transcriptional regulatory protein Lge1 is involved in the ubiquitination of histones H2A and H2B, a step that is vital in the regulation of the transcriptional activity of RNA polymerase II. In Saccharomyces cerevisiae, Lge1 (also called large cells protein 1), together with its interacting partner ubiquitin ligase Bre1, recruits Rad6, forming a complex that is required for H2B monoubiquitination, a process that regulates transcription, DNA replication, and DNA damage response and repair, ensuring the structural integrity of the genome. In S. pombe the equivalent protein to LGE1 appears to be small histone ubiquitination factor 1 (Shf1).


Pssm-ID: 439378  Cd Length: 82  Bit Score: 116.17  E-value: 5.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578056063 209 KRRVDKNDSPFLYLTdldKSTDDPKELEDIREVFKESDRLDKALEEHNFSLLKNELELGLLATQCEKDTLSVRLTQEKLD 288
Cdd:cd22897    1 ESESKEFNSPWIYLL---KGIKDEKTAEELEKIYKELDSLDKKLEELKLKKLKLELELSLLETQAERDALNVQLTQEKLD 77


                 ....
gi 578056063 289 TFLM 292
Cdd:cd22897   78 ELLL 81
Lge1 pfam11488
Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to ...
 230-291 2.39e-20

Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression.


Pssm-ID: 431907  Cd Length: 64  Bit Score: 82.69  E-value: 2.39e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578056063  230 DDPKELEDIREVFKESDRLDKALEEHNFSLLKNELELGLLATQCEKDTLSVRLTQEKLDTFL 291
Cdd:pfam11488   3 DDESTLKKIESKYKELEQLDKKLCELQLKVLKLELELDLLEEQAERDALNVQLTQEKLDEFL 64
Lge1_periphilin-like cd22825
Eukaryotic transcriptional regulatory protein Lge1, periphilin, and similar proteins; This ...
 230-292 1.17e-19

Eukaryotic transcriptional regulatory protein Lge1, periphilin, and similar proteins; This family includes transcriptional regulatory protein Lge1 found in fungi as well as periphilin-1, a component of the Human Silencing Hub (HUSH) complex, a multiprotein complex that mediates epigenetic repression. In yeasts, Lge1 is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In Saccharomyces cerevisiae, Rad6 and Bre1 are present in a complex that contains Lge1; this complex is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In Schizosaccharomyces pombe, the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression. In human, periphilin-1 is involved in epithelial differentiation and contributes to epidermal integrity and barrier formation. It may act as transcriptional co-repressor involved in cell cycle progression. Chromosomal translocation of genes causing oncogenic fusion protein of Periphilin-1 and Fibroblast Growth Factor Receptor 2 (FGRF2) is associated with intrahepatic cholangiocarcinoma.


Pssm-ID: 439376  Cd Length: 63  Bit Score: 80.92  E-value: 1.17e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578056063 230 DDPKELEDIREVFKESDRLDKALEEHNFSLLKNELELGLLATQCEKDTLSVRLTQEKLDTFLM 292
Cdd:cd22825    1 QLTTRSKAIASKTKEIEQVYRQDCETFGMVVKMLIEKDPSLEKSIQFALRQNLHEIGERCVEE 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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