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Conserved domains on  [gi|575523140|gb|AHG97947|]
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Plk-interacting checkpoint helicase, partial [Elassoma zonatum]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11425670)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  1.20.1320.20|3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 1-479 1.53e-128

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 388.81  E-value: 1.53e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSkmERTRNLEKVqRRGGVIITTYTMLMNNW 80
Cdd:COG0553  275 IQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR--ERAKGANPF-EDADLVITSYGLLRRDI 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  81 QQLAsyrgrEFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGtLLGTAKTFKAE 160
Cdd:COG0553  352 ELLA-----AVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPG-LLGSLKAFRER 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 161 YENPITRAREKdstpgekalgfrMSETLMTIIKPYFLRRTKAEVQKNklsgtheysdnkegkvqiphkdpgavmptLTRK 240
Cdd:COG0553  426 FARPIEKGDEE------------ALERLRRLLRPFLLRRTKEDVLKD-----------------------------LPEK 464

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 241 NDLIVWTYLSPAQEDIYRQFISL--DHIKELLMTSR--SPLAELTILKKLCDHPRMLsataiaklgLDEGRQqsdsetda 316
Cdd:COG0553  465 TEETLYVELTPEQRALYEAVLEYlrRELEGAEGIRRrgLILAALTRLRQICSHPALL---------LEEGAE-------- 527

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 317 htidnvsddaLISESGKLVFLFALLERLRQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTiTQITERERRIERFQ 396
Cdd:COG0553  528 ----------LSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGG-TSAEERDELVDRFQ 596

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 397 KDKRYSVFLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYRRQVFKDSL 476
Cdd:COG0553  597 EGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676


                 ...
gi 575523140 477 IRQ 479
Cdd:COG0553  677 AES 679
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 1-479 1.53e-128

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 388.81  E-value: 1.53e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSkmERTRNLEKVqRRGGVIITTYTMLMNNW 80
Cdd:COG0553  275 IQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR--ERAKGANPF-EDADLVITSYGLLRRDI 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  81 QQLAsyrgrEFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGtLLGTAKTFKAE 160
Cdd:COG0553  352 ELLA-----AVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPG-LLGSLKAFRER 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 161 YENPITRAREKdstpgekalgfrMSETLMTIIKPYFLRRTKAEVQKNklsgtheysdnkegkvqiphkdpgavmptLTRK 240
Cdd:COG0553  426 FARPIEKGDEE------------ALERLRRLLRPFLLRRTKEDVLKD-----------------------------LPEK 464

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 241 NDLIVWTYLSPAQEDIYRQFISL--DHIKELLMTSR--SPLAELTILKKLCDHPRMLsataiaklgLDEGRQqsdsetda 316
Cdd:COG0553  465 TEETLYVELTPEQRALYEAVLEYlrRELEGAEGIRRrgLILAALTRLRQICSHPALL---------LEEGAE-------- 527

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 317 htidnvsddaLISESGKLVFLFALLERLRQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTiTQITERERRIERFQ 396
Cdd:COG0553  528 ----------LSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGG-TSAEERDELVDRFQ 596

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 397 KDKRYSVFLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYRRQVFKDSL 476
Cdd:COG0553  597 EGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676


                 ...
gi 575523140 477 IRQ 479
Cdd:COG0553  677 AES 679
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 1-199 1.04e-122

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 357.84  E-value: 1.04e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERTRNLEKVQRRGGVIITTYTMLMNNW 80
Cdd:cd18001   34 VQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVFHGTSKKERERNLERIQRGGGVLLTTYGMVLSNT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  81 QQLASYRGREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGTLLGTAKTFKAE 160
Cdd:cd18001  114 EQLSADDHDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKME 193

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 575523140 161 YENPITRAREKDSTPGEKALGFRMSETLMTIIKPYFLRR 199
Cdd:cd18001  194 FENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 20-479 7.88e-67

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 232.00  E-value: 7.88e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   20 LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKmERTRNLEKVQRRGG--VIITTYTMLMNNWQQLasyrgREFTWDYMI 97
Cdd:PLN03142  223 MVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPE-ERAHQREELLVAGKfdVCVTSFEMAIKEKTAL-----KRFSWRYII 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   98 LDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFachgtLL----GTAKTFKAEYENpitrAREKDS 173
Cdd:PLN03142  297 IDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNF-----LLpeifSSAETFDEWFQI----SGENDQ 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  174 TpgekalgfRMSETLMTIIKPYFLRRTKAEVQKNklsgtheysdnkegkvqiphkdpgavmptLTRKNDLIVWTYLSPAQ 253
Cdd:PLN03142  368 Q--------EVVQQLHKVLRPFLLRRLKSDVEKG-----------------------------LPPKKETILKVGMSQMQ 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  254 EDIYRQFISLDhiKELLMT--SRSPLAELTI-LKKLCDHPRMLSataiaklGLDEGRQQSdseTDAHTIDNvsddalise 330
Cdd:PLN03142  411 KQYYKALLQKD--LDVVNAggERKRLLNIAMqLRKCCNHPYLFQ-------GAEPGPPYT---TGEHLVEN--------- 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  331 SGKLVFLFALLERLRQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTiTQITERERRIERFQKDKRYS-VFLLTTQ 409
Cdd:PLN03142  470 SGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGN-TGGEDRDASIDAFNKPGSEKfVFLLSTR 548

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 575523140  410 VGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYRRQVFK---DSLIRQ 479
Cdd:PLN03142  549 AGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKlalDALVIQ 621
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 1-293 2.17e-50

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 173.64  E-value: 2.17e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140    1 IQVITFLSGMYDCELVKHC--LLVMPTSLITNWTKEFAKWT--PGMRVKEFHGT-SKMERTRNLEKVQRRGGVIITTYTM 75
Cdd:pfam00176  32 LQTISLLLYLKHVDKNWGGptLIVVPLSLLHNWMNEFERWVspPALRVVVLHGNkRPQERWKNDPNFLADFDVVITTYET 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   76 LMNNWQQLASYRgreftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAcHGTLLGTAK 155
Cdd:pfam00176 112 LRKHKELLKKVH-----WHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFL-RPGPFGSLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  156 TFKAEYENPITRAREKDStpgekalgfrmSETLMTIIKPYFLRRTKAEVQKNklsgtheysdnkegkvqiphkdpgavmp 235
Cdd:pfam00176 186 TFRNWFDRPIERGGGKKG-----------VSRLHKLLKPFLLRRTKKDVEKS---------------------------- 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 575523140  236 tLTRKNDLIVWTYLSPAQEDIYRQFISLDHIKELL------MTSRSPLAELTILKKLCDHPRML 293
Cdd:pfam00176 227 -LPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKtgeggrEIKASLLNILMRLRKICNHPGLI 289
HELICc smart00490
helicase superfamily c-terminal domain;
362-446 6.91e-24

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 94.97  E-value: 6.91e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   362 DIIERILGNRGFKVMRLDGTITQItERERRIERFQKDKRysVFLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDR 441
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQE-EREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77


                   ....*
gi 575523140   442 AYRIG 446
Cdd:smart00490  78 AGRAG 82
rad25 TIGR00603
DNA repair helicase rad25; All proteins in this family for which functions are known are ...
 7-104 3.53e-03

DNA repair helicase rad25; All proteins in this family for which functions are known are DNA-DNA helicases used for the initiation of nucleotide excision repair and transacription as part of the TFIIH complex.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273168 [Multi-domain]  Cd Length: 732  Bit Score: 40.17  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140    7 LSGMYDCELVKHCLLVMPTSLIT--NWTKEFAKWT---PGMrVKEFHGTSKmertrnlEKVQRRGGVIITTYTMLMNNWQ 81
Cdd:TIGR00603 288 LVGVTAACTVKKSCLVLCTSAVSveQWKQQFKMWStidDSQ-ICRFTSDAK-------ERFHGEAGVVVSTYSMVAHTGK 359

                          90       100       110
                  ....*....|....*....|....*....|..
gi 575523140   82 QlaSY---------RGREftWDYMILDEAHKI 104
Cdd:TIGR00603 360 R--SYesekvmewlTNRE--WGLILLDEVHVV 387
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 1-479 1.53e-128

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 388.81  E-value: 1.53e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSkmERTRNLEKVqRRGGVIITTYTMLMNNW 80
Cdd:COG0553  275 IQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR--ERAKGANPF-EDADLVITSYGLLRRDI 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  81 QQLAsyrgrEFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGtLLGTAKTFKAE 160
Cdd:COG0553  352 ELLA-----AVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPG-LLGSLKAFRER 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 161 YENPITRAREKdstpgekalgfrMSETLMTIIKPYFLRRTKAEVQKNklsgtheysdnkegkvqiphkdpgavmptLTRK 240
Cdd:COG0553  426 FARPIEKGDEE------------ALERLRRLLRPFLLRRTKEDVLKD-----------------------------LPEK 464

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 241 NDLIVWTYLSPAQEDIYRQFISL--DHIKELLMTSR--SPLAELTILKKLCDHPRMLsataiaklgLDEGRQqsdsetda 316
Cdd:COG0553  465 TEETLYVELTPEQRALYEAVLEYlrRELEGAEGIRRrgLILAALTRLRQICSHPALL---------LEEGAE-------- 527

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 317 htidnvsddaLISESGKLVFLFALLERLRQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTiTQITERERRIERFQ 396
Cdd:COG0553  528 ----------LSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGG-TSAEERDELVDRFQ 596

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 397 KDKRYSVFLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYRRQVFKDSL 476
Cdd:COG0553  597 EGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676


                 ...
gi 575523140 477 IRQ 479
Cdd:COG0553  677 AES 679
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 1-199 1.04e-122

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 357.84  E-value: 1.04e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERTRNLEKVQRRGGVIITTYTMLMNNW 80
Cdd:cd18001   34 VQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVFHGTSKKERERNLERIQRGGGVLLTTYGMVLSNT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  81 QQLASYRGREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGTLLGTAKTFKAE 160
Cdd:cd18001  114 EQLSADDHDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKME 193

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 575523140 161 YENPITRAREKDSTPGEKALGFRMSETLMTIIKPYFLRR 199
Cdd:cd18001  194 FENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 20-479 7.88e-67

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 232.00  E-value: 7.88e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   20 LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKmERTRNLEKVQRRGG--VIITTYTMLMNNWQQLasyrgREFTWDYMI 97
Cdd:PLN03142  223 MVVAPKSTLGNWMNEIRRFCPVLRAVKFHGNPE-ERAHQREELLVAGKfdVCVTSFEMAIKEKTAL-----KRFSWRYII 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   98 LDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFachgtLL----GTAKTFKAEYENpitrAREKDS 173
Cdd:PLN03142  297 IDEAHRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNF-----LLpeifSSAETFDEWFQI----SGENDQ 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  174 TpgekalgfRMSETLMTIIKPYFLRRTKAEVQKNklsgtheysdnkegkvqiphkdpgavmptLTRKNDLIVWTYLSPAQ 253
Cdd:PLN03142  368 Q--------EVVQQLHKVLRPFLLRRLKSDVEKG-----------------------------LPPKKETILKVGMSQMQ 410

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  254 EDIYRQFISLDhiKELLMT--SRSPLAELTI-LKKLCDHPRMLSataiaklGLDEGRQQSdseTDAHTIDNvsddalise 330
Cdd:PLN03142  411 KQYYKALLQKD--LDVVNAggERKRLLNIAMqLRKCCNHPYLFQ-------GAEPGPPYT---TGEHLVEN--------- 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  331 SGKLVFLFALLERLRQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTiTQITERERRIERFQKDKRYS-VFLLTTQ 409
Cdd:PLN03142  470 SGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGN-TGGEDRDASIDAFNKPGSEKfVFLLSTR 548

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 575523140  410 VGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYRRQVFK---DSLIRQ 479
Cdd:PLN03142  549 AGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKlalDALVIQ 621
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 331-457 1.49e-61

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 197.31  E-value: 1.49e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 331 SGKLVFLFALLERLRQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTiTQITERERRIERFQKDKRYSVFLLTTQV 410
Cdd:cd18793   10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGS-TSSKERQKLVDRFNEDPDIRVFLLSTKA 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 575523140 411 GGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLI 457
Cdd:cd18793   89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 1-201 2.19e-54

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 181.61  E-value: 2.19e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGT-SKMERTRNLEKVQrrggVIITTYTMLmnn 79
Cdd:cd18012   38 LQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVIHGTkRKREKLRALEDYD----LVITSYGLL--- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  80 WQQLASYRGREftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFaCHGTLLGTAKTFKA 159
Cdd:cd18012  111 RRDIELLKEVK--FHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDF-LNPGLLGSYKRFKK 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 575523140 160 EYENPITRAREKDStpgekalgfrmSETLMTIIKPYFLRRTK 201
Cdd:cd18012  188 RFAKPIEKDGDEEA-----------LEELKKLISPFILRRLK 218
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 1-151 7.03e-52

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 173.91  E-value: 7.03e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCEL-VKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERTRNLEKVQRRGGVIITTYTMLMNN 79
Cdd:cd17919   34 LQAIAFLAYLLKEGKeRGPVLVVCPLSVLENWEREFEKWTPDLRVVVYHGSQRERAQIRAKEKLDKFDVVLTTYETLRRD 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 575523140  80 WQQLasyrgREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGTLL 151
Cdd:cd17919  114 KASL-----RKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFLDPPFLL 180
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 1-293 2.17e-50

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 173.64  E-value: 2.17e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140    1 IQVITFLSGMYDCELVKHC--LLVMPTSLITNWTKEFAKWT--PGMRVKEFHGT-SKMERTRNLEKVQRRGGVIITTYTM 75
Cdd:pfam00176  32 LQTISLLLYLKHVDKNWGGptLIVVPLSLLHNWMNEFERWVspPALRVVVLHGNkRPQERWKNDPNFLADFDVVITTYET 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   76 LMNNWQQLASYRgreftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAcHGTLLGTAK 155
Cdd:pfam00176 112 LRKHKELLKKVH-----WHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFL-RPGPFGSLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  156 TFKAEYENPITRAREKDStpgekalgfrmSETLMTIIKPYFLRRTKAEVQKNklsgtheysdnkegkvqiphkdpgavmp 235
Cdd:pfam00176 186 TFRNWFDRPIERGGGKKG-----------VSRLHKLLKPFLLRRTKKDVEKS---------------------------- 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 575523140  236 tLTRKNDLIVWTYLSPAQEDIYRQFISLDHIKELL------MTSRSPLAELTILKKLCDHPRML 293
Cdd:pfam00176 227 -LPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKtgeggrEIKASLLNILMRLRKICNHPGLI 289
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 1-199 1.47e-44

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 156.29  E-value: 1.47e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFL-----SGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEF---HGTSKMERTRNLEKVQRRGGVIITT 72
Cdd:cd18004   39 LQAIALVwtllkQGPYGKPTAKKALIVCPSSLVGNWKAEFDKWLGLRRIKVVtadGNAKDVKASLDFFSSASTYPVLIIS 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  73 YTMLMNNWQQLASyrGREFtwDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGtLLG 152
Cdd:cd18004  119 YETLRRHAEKLSK--KISI--DLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPG-ILG 193

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 575523140 153 TAKTFKAEYENPITRAREKDSTPGEKALGFRMSETLMTIIKPYFLRR 199
Cdd:cd18004  194 SLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 1-201 1.65e-37

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 137.52  E-value: 1.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTsKMERTRNLEKVQRRGG------VIITTYT 74
Cdd:cd18009   37 IQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLYHGT-KEERERLRKKIMKREGtlqdfpVVVTSYE 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  75 MLMNNWQQLASYrgrefTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFD------FACHG 148
Cdd:cd18009  116 IAMRDRKALQHY-----AWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNfllpdvFDDLS 190

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 575523140 149 TLLG----TAKTFKAEYENPITRAREKDstpgekalgfrMSETLMTIIKPYFLRRTK 201
Cdd:cd18009  191 SFESwfdfSSLSDNAADISNLSEEREQN-----------IVHMLHAILKPFLLRRLK 236
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 1-199 1.11e-36

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 135.58  E-value: 1.11e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMY---------------------DCELVKHCLLVMPTSLITNWTKEFAKWTpGMRVKEFHGTSKmERTRNL 59
Cdd:cd18005   34 VQVIAFLAAVLgktgtrrdrennrprfkkkppASSAKKPVLIVAPLSVLYNWKDELDTWG-HFEVGVYHGSRK-DDELEG 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  60 EKVQRRGGVIITTYTMLMNNWQQLAsyrgrEFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMW 139
Cdd:cd18005  112 RLKAGRLEVVVTTYDTLRRCIDSLN-----SINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELW 186

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 140 ALFDFACHGtLLGTAKTFKAEYENPITRAREKDSTPGEKALGFRMSETLMTIIKPYFLRR 199
Cdd:cd18005  187 CLLDWAVPG-ALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 20-199 5.55e-35

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 130.55  E-value: 5.55e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTP--GMRVKEFHGTSkmERTRNLEKVQRRGGVIITTYTMLMNNWQQLasyrgREFTWDYMI 97
Cdd:cd17999   59 LVVCPPTLVGHWVAEIKKYFPnaFLKPLAYVGPP--QERRRLREQGEKHNVIVASYDVLRNDIEVL-----TKIEWNYCV 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  98 LDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGtLLGTAKTFKAEYENPITRAREKDSTPGE 177
Cdd:cd17999  132 LDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPG-YLGTEKQFQRRFLKPILASRDSKASAKE 210

                        170       180
                 ....*....|....*....|..
gi 575523140 178 KALGFRMSETLMTIIKPYFLRR 199
Cdd:cd17999  211 QEAGALALEALHKQVLPFLLRR 232
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 1-144 5.62e-35

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 129.37  E-value: 5.62e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGM-YDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTS----------KMERTRNL-EKVQRRGGV 68
Cdd:cd18000   34 IQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVVLHSSGsgtgseeklgSIERKSQLiRKVVGDGGI 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 575523140  69 IITTYTMLMNNWQQLASYRgreftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18000  114 LITTYEGFRKHKDLLLNHN-----WQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDF 184
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 2-180 7.15e-35

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 130.49  E-value: 7.15e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   2 QVITFL-SGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRV-------KEFHGTSKmERTRNLEKVQRRGGVIITTY 73
Cdd:cd18007   42 QVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWLPPDLRpllvlvsLSASKRAD-ARLRKINKWHKEGGVLLIGY 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  74 TM---LMNNWQQLASYRGREFTW------DYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18007  121 ELfrnLASNATTDPRLKQEFIAAlldpgpDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDF 200

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 575523140 145 ACHGtLLGTAKTFKAEYENPITRAREKDSTPGEKAL 180
Cdd:cd18007  201 ARPK-YLGTLKEFKKKFVKPIEAGQCVDSTEEDVRL 235
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 1-201 6.81e-33

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 124.36  E-value: 6.81e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMydcelvKHC-------LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTsKMERTRNLEKVQRRG--GVIIT 71
Cdd:cd17997   37 LQTISLLGYL------KHYkningphLIIVPKSTLDNWMREFKRWCPSLRVVVLIGD-KEERADIIRDVLLPGkfDVCIT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  72 TYTMLMNNWQQLasyrgREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFachgtLL 151
Cdd:cd17997  110 SYEMVIKEKTVL-----KKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNF-----LL 179

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 575523140 152 ----GTAKTFKAEYENpitrarEKDSTPGEKalgfrMSETLMTIIKPYFLRRTK 201
Cdd:cd17997  180 pdvfTSSEDFDEWFNV------NNCDDDNQE-----VVQRLHKVLRPFLLRRIK 222
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 9-199 9.54e-33

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 124.57  E-value: 9.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   9 GMYDCE-LVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFhgtsKMERTRNLEKVQRRG--GVIITTYTMLMNNWQQLAS 85
Cdd:cd18066   52 GPYGGKpVIKRALIVTPGSLVKNWKKEFQKWLGSERIKVF----TVDQDHKVEEFIASPlySVLIISYEMLLRSLDQISK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  86 yrgreFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFaCHGTLLGTAKTFKAEYENPI 165
Cdd:cd18066  128 -----LNFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDF-VNPGILGSLSTYRKVYEEPI 201

                        170       180       190
                 ....*....|....*....|....*....|....
gi 575523140 166 TRAREKDSTPGEKALGFRMSETLMTIIKPYFLRR 199
Cdd:cd18066  202 VRSREPTATPEEKKLGEARAAELTRLTGLFILRR 235
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 1-201 1.53e-30

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 118.24  E-value: 1.53e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDcelVKHC----LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERTrnLEKVQRRG--GVIITTYT 74
Cdd:cd17996   37 IQTISLITYLME---KKKNngpyLVIVPLSTLSNWVSEFEKWAPSVSKIVYKGTPDVRKK--LQSQIRAGkfNVLLTTYE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  75 MLMNNWQQLASYRgreftWDYMILDEAHKIKTSTTK-TAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAChGTLLGT 153
Cdd:cd17996  112 YIIKDKPLLSKIK-----WKYMIIDEGHRMKNAQSKlTQTLNTYYHARYRLLLTGTPLQNNLPELWALLNFLL-PKIFKS 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 575523140 154 AKTFKAEYENPITrarekdSTPGEKALGFRMSETLMTI------IKPYFLRRTK 201
Cdd:cd17996  186 CKTFEQWFNTPFA------NTGEQVKIELNEEETLLIIrrlhkvLRPFLLRRLK 233
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 1-199 9.51e-30

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 115.81  E-value: 9.51e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVM-PTSLITNWTKEFAKWTPgMRVKEFHGT-------SKMERTRNLEKVQRRGG----- 67
Cdd:cd17995   34 IQSIAFLEHLYQVEGIRGPFLVIaPLSTIPNWQREFETWTD-MNVVVYHGSgesrqiiQQYEMYFKDAQGRKKKGvykfd 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  68 VIITTYTMLMNNWQQLasyrgREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFaCH 147
Cdd:cd17995  113 VLITTYEMVIADAEEL-----RKIPWRVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNF-LE 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 575523140 148 GTLLGTAKTFKAEYenpitrareKDSTPGEKAlgfrmsETLMTIIKPYFLRR 199
Cdd:cd17995  187 PEKFPSSEEFLEEF---------GDLKTAEQV------EKLQALLKPYMLRR 223
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 1-199 4.88e-29

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 113.99  E-value: 4.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGM-YDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKmERtrnleKVQRRG-------GVIITT 72
Cdd:cd18003   34 IQTIALLAHLaCEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILTYYGSAK-ER-----KLKRQGwmkpnsfHVCITS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  73 YTMLMnnwQQLASYRGREftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAChGTLLG 152
Cdd:cd18003  108 YQLVV---QDHQVFKRKK--WKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLM-PHIFQ 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 575523140 153 TAKTFKAEYENPITRAREKDSTPGEKALgfrmsETLMTIIKPYFLRR 199
Cdd:cd18003  182 SHQEFKEWFSNPLTAMSEGSQEENEELV-----RRLHKVLRPFLLRR 223
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 332-446 1.06e-27

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 106.53  E-value: 1.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  332 GKLVFLFALLERlrQEGHRTLIFAHYRKVLDIiERILGNRGFKVMRLDGTITQItERERRIERFQKDKRysVFLLTTQVG 411
Cdd:pfam00271   1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQE-EREEILEDFRKGKI--DVLVATDVA 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 575523140  412 GVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIG 446
Cdd:pfam00271  75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 5-199 3.44e-27

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 109.48  E-value: 3.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   5 TFLSGMYDCE-LVKHCLLVMPTSLITNWTKEFAKWTpGMRVKEF--HGTSKMERTRNLEK-VQRRGG-----VIITTYTM 75
Cdd:cd18067   47 TLLRQSPQCKpEIDKAIVVSPSSLVKNWANELGKWL-GGRLQPLaiDGGSKKEIDRKLVQwASQQGRrvstpVLIISYET 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  76 LMNNWQQLASYrgrefTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGtLLGTAK 155
Cdd:cd18067  126 FRLHVEVLQKG-----EVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPG-ILGTAA 199

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 575523140 156 TFKAEYENPITRAREKDSTPGEKALGFRMSETLMTIIKPYFLRR 199
Cdd:cd18067  200 EFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNRCIIRR 243
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 1-180 3.99e-27

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 108.75  E-value: 3.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKW------TPGMRVKEF--HGTSKMERTRN-----LEKVQRRGG 67
Cdd:cd18069   43 LQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWlpppeaLPNVRPRPFkvFILNDEHKTTAarakvIEDWVKDGG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  68 VIITTYTMlmnnwqqlasYRGREFTwDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACH 147
Cdd:cd18069  123 VLLMGYEM----------FRLRPGP-DVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRP 191

                        170       180       190
                 ....*....|....*....|....*....|...
gi 575523140 148 GtLLGTAKTFKAEYENPITRAREKDSTPGEKAL 180
Cdd:cd18069  192 D-FLGTRQEFSNMFERPILNGQCVDSTPQDVKL 223
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 1-144 4.03e-27

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 107.47  E-value: 4.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGtSKMERTRNLEKVQRRGG---VIITTYTMLM 77
Cdd:cd17998   34 IQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPYYG-SQEERKHLRYDILKGLEdfdVIVTTYNLAT 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 575523140  78 NNWQQLASYRGREFtwDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd17998  113 SNPDDRSFFKRLKL--NYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNF 177
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 1-199 8.39e-27

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 107.44  E-value: 8.39e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMY-DCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERT-RNLEKVQRRG-----GVIITTY 73
Cdd:cd17993   35 VQTISFLSYLFhSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVIVYLGDIKSRDTiREYEFYFSQTkklkfNVLLTTY 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  74 TMLMNNWQQLASYRgreftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHGTLlgt 153
Cdd:cd17993  115 EIILKDKAFLGSIK-----WQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKF--- 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 575523140 154 akTFKAEYENPITRAREKDstpgekalgfrmSETLMTIIKPYFLRR 199
Cdd:cd17993  187 --DIWEEFEEEHDEEQEKG------------IADLHKELEPFILRR 218
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 20-199 2.69e-26

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 106.99  E-value: 2.69e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAK--WTPGMRVKEFHGTSKMERTRNLEKVqrrgGVIITTYTMLMNNWQQLASYRGR-------- 89
Cdd:cd18008   66 LIVVPLSLLSQWKDEIEKhtKPGSLKVYVYHGSKRIKSIEELSDY----DIVITTYGTLASEFPKNKKGGGRdskekeas 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  90 ---EFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFachgtllgtaKTFKAEYENPIT 166
Cdd:cd18008  142 plhRIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRF----------LRVEPFGDYPWF 211

                        170       180       190
                 ....*....|....*....|....*....|...
gi 575523140 167 RAREKDSTPGEKALGFRMsetLMTIIKPYFLRR 199
Cdd:cd18008  212 NSDISKPFSKNDRKALER---LQALLKPILLRR 241
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 1-175 1.73e-25

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 104.58  E-value: 1.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHC---LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKM-------ERTRNLEKVQRRGGVII 70
Cdd:cd18068   43 LQVVTFLHTVLLCEKLENFsrvLVVCPLNTVLNWLNEFEKWQEGLKDEEKIEVNELatykrpqERSYKLQRWQEEGGVMI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  71 TTYTMLMNNWQQLASYRGREFTWDYM-----------ILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMW 139
Cdd:cd18068  123 IGYDMYRILAQERNVKSREKLKEIFNkalvdpgpdfvVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYH 202

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 575523140 140 ALFDFACHGtLLGTAKTFKAEYENPITRAREKDSTP 175
Cdd:cd18068  203 CMVNFVKPN-LLGTIKEFRNRFVNPIQNGQCADSTL 237
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 20-207 2.10e-24

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 101.67  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTPGMRVKEFHGtSKMERTRNLEKVQRRG--GVIITTYTMLMNNWQQLasyrgREFTWDYMI 97
Cdd:cd18064   69 MVLVPKSTLHNWMAEFKRWVPTLRAVCLIG-DKDQRAAFVRDVLLPGewDVCVTSYEMLIKEKSVF-----KKFNWRYLV 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  98 LDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAChGTLLGTAKTFKAEYENpitrarekDSTPGE 177
Cdd:cd18064  143 IDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLL-PDVFNSAEDFDSWFDT--------NNCLGD 213

                        170       180       190
                 ....*....|....*....|....*....|
gi 575523140 178 KalgfRMSETLMTIIKPYFLRRTKAEVQKN 207
Cdd:cd18064  214 Q----KLVERLHMVLRPFLLRRIKADVEKS 239
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 20-199 6.09e-24

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 99.89  E-value: 6.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSK----MERTRNLEKVQRRGG---VIITTYTMLMNNWQQLASYRgreft 92
Cdd:cd18002   54 LVIAPASTLHNWQQEISRFVPQFKVLPYWGNPKdrkvLRKFWDRKNLYTRDApfhVVITSYQLVVQDEKYFQRVK----- 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  93 WDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAChGTLLGTAKTFKAEYENPITRAREKD 172
Cdd:cd18002  129 WQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIM-PTLFDSHDEFNEWFSKDIESHAENK 207

                        170       180
                 ....*....|....*....|....*..
gi 575523140 173 STPGEKALgfrmsETLMTIIKPYFLRR 199
Cdd:cd18002  208 TGLNEHQL-----KRLHMILKPFMLRR 229
HELICc smart00490
helicase superfamily c-terminal domain;
362-446 6.91e-24

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 94.97  E-value: 6.91e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   362 DIIERILGNRGFKVMRLDGTITQItERERRIERFQKDKRysVFLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDR 441
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQE-EREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77


                   ....*
gi 575523140   442 AYRIG 446
Cdd:smart00490  78 AGRAG 82
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 1-201 1.01e-23

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 99.75  E-value: 1.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLsgMYDCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERTRNLEKVQRRGGVIITTYTMLMNNW 80
Cdd:cd18063   60 IALITYL--MEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDK 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  81 QQLASYRgreftWDYMILDEAHKIKTSTTKTAK--SAHAVpSTNRVLLTGTPVQNNLKEMWALFDFAChGTLLGTAKTFK 158
Cdd:cd18063  138 HILAKIR-----WKYMIVDEGHRMKNHHCKLTQvlNTHYV-APRRILLTGTPLQNKLPELWALLNFLL-PTIFKSCSTFE 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 575523140 159 AEYENPITRAREK-DSTPGEKALGFRmseTLMTIIKPYFLRRTK 201
Cdd:cd18063  211 QWFNAPFAMTGERvDLNEEETILIIR---RLHKVLRPFLLRRLK 251
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 1-199 1.23e-23

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 99.31  E-value: 1.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDC-ELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERT-RNLEKVQRRG-----GVIITTY 73
Cdd:cd18054   54 IQTISFLSYLFHQhQLYGPFLLVVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTiREYEWIHSQTkrlkfNALITTY 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  74 TMLMNNWQQLASyrgreFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFachgtLLGT 153
Cdd:cd18054  134 EILLKDKTVLGS-----INWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHF-----IMPE 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 575523140 154 AKTFKAEYENPITRAREKdstpgekalGFrmsETLMTIIKPYFLRR 199
Cdd:cd18054  204 KFEFWEDFEEDHGKGREN---------GY---QSLHKVLEPFLLRR 237
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 20-201 1.01e-22

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 96.63  E-value: 1.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTPGMRVKEFHGtSKMERTRNLEKVQRRG--GVIITTYTMLMNNWQQLasyrgREFTWDYMI 97
Cdd:cd18065   69 MVLVPKSTLHNWMNEFKRWVPSLRAVCLIG-DKDARAAFIRDVMMPGewDVCVTSYEMVIKEKSVF-----KKFNWRYLV 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  98 LDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAChGTLLGTAKTFKAEYENPITRAREKdstpge 177
Cdd:cd18065  143 IDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLL-PDVFNSADDFDSWFDTKNCLGDQK------ 215

                        170       180
                 ....*....|....*....|....
gi 575523140 178 kalgfrMSETLMTIIKPYFLRRTK 201
Cdd:cd18065  216 ------LVERLHAVLKPFLLRRIK 233
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 20-201 9.14e-22

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 94.34  E-value: 9.14e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERTRNLEKVQRRGGVIITTYTMLMNNWQQLASYRgreftWDYMILD 99
Cdd:cd18062   77 LIIVPLSTLSNWVYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKDKQILAKIR-----WKYMIVD 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 100 EAHKIKTSTTKTAK--SAHAVpSTNRVLLTGTPVQNNLKEMWALFDFAChGTLLGTAKTFKAEYENPITRAREK-DSTPG 176
Cdd:cd18062  152 EGHRMKNHHCKLTQvlNTHYV-APRRLLLTGTPLQNKLPELWALLNFLL-PTIFKSCSTFEQWFNAPFAMTGEKvDLNEE 229

                        170       180
                 ....*....|....*....|....*
gi 575523140 177 EKALGFRmseTLMTIIKPYFLRRTK 201
Cdd:cd18062  230 ETILIIR---RLHKVLRPFLLRRLK 251
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 1-199 1.28e-20

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 90.50  E-value: 1.28e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPgMRVKEFHGT---SKMERTRNLEKVQRRGGVI-------- 69
Cdd:cd18060   34 IQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTE-MNTIVYHGSlasRQMIQQYEMYCKDSRGRLIpgaykfda 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  70 -ITTYTMLMNNWQQLasyrgREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFachg 148
Cdd:cd18060  113 lITTFEMILSDCPEL-----REIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHF---- 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575523140 149 tllgtakTFKAEYENPITRAREKDSTPGEKALgfrmsETLMTIIKPYFLRR 199
Cdd:cd18060  184 -------LEPSQFPSESEFLKDFGDLKTEEQV-----QKLQAILKPMMLRR 222
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 1-199 1.87e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 87.02  E-value: 1.87e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPgMRVKEFHGtSKMERT--RNLEKVQR-----------RGG 67
Cdd:cd18058   34 IQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWTE-MNAIVYHG-SQISRQmiQQYEMYYRdeqgnplsgifKFQ 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  68 VIITTYTMLMNNWQQLasyrgREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFaCH 147
Cdd:cd18058  112 VVITTFEMILADCPEL-----KKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNF-LE 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 575523140 148 GTLLGTAKTFKAEYENPITRAREKdstpgekalgfrmseTLMTIIKPYFLRR 199
Cdd:cd18058  186 PSQFPSETTFLEEFGDLKTEEQVK---------------KLQSILKPMMLRR 222
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 20-144 2.50e-18

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 84.07  E-value: 2.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTPG--MRVKEFHGTSKMERTRNLekvqRRGGVIITTYTMLMNnwqQLASYRGREFT----- 92
Cdd:cd18072   77 LVVCPASLVHQWKNEVESRVASnkLRVCLYHGPNRERIGEVL----RDYDIVITTYSLVAK---EIPTYKEESRSsplfr 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 575523140  93 --WDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18072  150 iaWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKF 203
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 20-199 6.26e-18

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 82.49  E-value: 6.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTPGMRVKEFHGtSKMERT---RNLeKVQRRGGVIITTYTMLMNNWQQLASyrgreFTWDYM 96
Cdd:cd18006   54 LVLCPLSVLDNWKEELNRFAPDLSVITYMG-DKEKRLdlqQDI-KSTNRFHVLLTTYEICLKDASFLKS-----FPWASL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  97 ILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFaCHGTLLGtaktfKAEYENPITRAREKDSTPG 176
Cdd:cd18006  127 VVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSF-IEPNVFP-----KDKLDDFIKAYSETDDESE 200

                        170       180
                 ....*....|....*....|...
gi 575523140 177 ekalgfrMSETLMTIIKPYFLRR 199
Cdd:cd18006  201 -------TVEELHLLLQPFLLRR 216
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 1-144 1.87e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 81.63  E-value: 1.87e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMY-DCELVKHCLLVMPTSLITNWTKEFAKWTPGMRVKEFHG---TSKMERTRNLEKVQRRG---GVIITTY 73
Cdd:cd18053   54 IQTISFLNYLFhEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVVYLGdinSRNMIRTHEWMHPQTKRlkfNILLTTY 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 575523140  74 TMLMNNWQQLASyrgreFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18053  134 EILLKDKSFLGG-----LNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHF 199
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 1-146 2.16e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 80.18  E-value: 2.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYdceLVKHC----LLVMPTSLITNWTKEFAKWTPGMRVKEFHGTSkmertrnlekvqrrggVIITTYTML 76
Cdd:cd17994   34 IQTIVFLYSLY---KEGHSkgpfLVSAPLSTIINWEREFEMWAPDFYVVTYVGDH----------------VLLTSYELI 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  77 MNNWQQLASYRgreftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFAC 146
Cdd:cd17994   95 SIDQAILGSID-----WAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLT 159
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 1-199 6.85e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 79.69  E-value: 6.85e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTPgMRVKEFHGTSKMERTRNLEKVQRR---GGVI-------- 69
Cdd:cd18059   34 IQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTE-LNVVVYHGSQASRRTIQLYEMYFKdpqGRVIkgsykfha 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  70 -ITTYTMLMNNWQQLasyrgREFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFACHG 148
Cdd:cd18059  113 iITTFEMILTDCPEL-----RNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPS 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575523140 149 TlLGTAKTFKAEYENPITRARekdstpgekalgfrmSETLMTIIKPYFLRR 199
Cdd:cd18059  188 R-FPSETTFMQEFGDLKTEEQ---------------VQKLQAILKPMMLRR 222
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 20-144 1.70e-15

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 75.97  E-value: 1.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWT-PG-MRVKEFHGTskmERTRNLEKVQRRGgVIITTYTMLMNNWQQLASYRGREFTWDYMI 97
Cdd:cd18071   75 LIVCPLSVLSNWETQFEEHVkPGqLKVYTYHGG---ERNRDPKLLSKYD-IVLTTYNTLASDFGAKGDSPLHTINWLRVV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 575523140  98 LDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18071  151 LDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSF 197
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 1-199 1.27e-14

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 73.12  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLVMPTSLITNWTKEFAKWTpGMRVKEFHGT---SKMERTRNLEKVQRRGGVI-------- 69
Cdd:cd18061   34 IQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVYHGSlisRQMIQQYEMYFRDSQGRIIrgayrfqa 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  70 -ITTYTMLMNNWQQLASyrgreFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDFaCHG 148
Cdd:cd18061  113 iITTFEMILGGCPELNA-----IDWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHF-LEP 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575523140 149 TLLGTAKTFKAEYENPITRARekdstpgekalgfrmSETLMTIIKPYFLRR 199
Cdd:cd18061  187 LRFPSESTFMQEFGDLKTEEQ---------------VQKLQAILKPMMLRR 222
DEXDc smart00487
DEAD-like helicases superfamily;
1-142 4.83e-14

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 70.98  E-value: 4.83e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140     1 IQVITFLSGMYDCELVKHCLLVMPT-SLITNWTKEFAKWTPGMRVK---EFHGTSKMERTRNLEKvqRRGGVIITTYTML 76
Cdd:smart00487  39 LAALLPALEALKRGKGGRVLVLVPTrELAEQWAEELKKLGPSLGLKvvgLYGGDSKREQLRKLES--GKTDILVTTPGRL 116

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 575523140    77 MNNWQQLASYRGReftWDYMILDEAHKIKTSTTK---TAKSAHAVPSTNRVLLTGTPVQNNLKEMWALF 142
Cdd:smart00487 117 LDLLENDKLSLSN---VDLVILDEAHRLLDGGFGdqlEKLLKLLPKNVQLLLLSATPPEEIENLLELFL 182
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 1-144 1.03e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 70.48  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLV-MPTSLITNWTKEFAKWTPGMRVKEFHGTSK-----MERTRNLEKVQRRGG------- 67
Cdd:cd18056   34 VQTAVFLYSLYKEGHSKGPFLVsAPLSTIINWEREFEMWAPDMYVVTYVGDKDsraiiRENEFSFEDNAIRGGkkasrmk 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  68 --------VIITTYTMLMNNWQQLASyrgreFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMW 139
Cdd:cd18056  114 keasvkfhVLLTSYELITIDMAILGS-----IDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELF 188


                 ....*
gi 575523140 140 ALFDF 144
Cdd:cd18056  189 HLLNF 193
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 1-144 1.33e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 70.04  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLV-MPTSLITNWTKEFAKWTPGMRVKEFHGTSK-----MERTRNLEKVQRRGG------- 67
Cdd:cd18055   34 IQTIVFLYSLYKEGHTKGPFLVsAPLSTIINWEREFQMWAPDFYVVTYTGDKDsraiiRENEFSFDDNAVKGGkkafkmk 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  68 --------VIITTYTMLMNNWQQLASYRgreftWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMW 139
Cdd:cd18055  114 reaqvkfhVLLTSYELVTIDQAALGSIR-----WACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELF 188


                 ....*
gi 575523140 140 ALFDF 144
Cdd:cd18055  189 HLLNF 193
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 1-144 9.01e-13

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 67.78  E-value: 9.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   1 IQVITFLSGMYDCELVKHCLLV-MPTSLITNWTKEFAKWTPGMRVKEFHGTSKMERT--------------------RNL 59
Cdd:cd18057   34 VQTIVFLYSLYKEGHSKGPYLVsAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVirenefsfednairsgkkvfRMK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  60 EKVQRRGGVIITTYTMLMNNWQQLASyrgreFTWDYMILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMW 139
Cdd:cd18057  114 KEAQIKFHVLLTSYELITIDQAILGS-----IEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELF 188


                 ....*
gi 575523140 140 ALFDF 144
Cdd:cd18057  189 HLLNF 193
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 20-199 5.71e-12

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 64.92  E-value: 5.71e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTPGMRVKEFH--GTSKMERTRnlekvqRRGGVIITTYTMLMNNWQQLASYRgreftWDYMI 97
Cdd:cd18010   47 LIVCPSSLRLTWADEIERWLPSLPPDDIQviVKSKDGLRD------GDAKVVIVSYDLLRRLEKQLLARK-----FKVVI 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  98 LDEAHKIKTSTTKTAKSahAVP---STNRV-LLTGTPVQNNLKEMWALFDFACHGtLLGTAKTFKAEYENPITRAREKD- 172
Cdd:cd18010  116 CDESHYLKNSKAKRTKA--ALPllkRAKRViLLSGTPALSRPIELFTQLDALDPK-LFGRFHDFGRRYCAAKQGGFGWDy 192

                        170       180
                 ....*....|....*....|....*...
gi 575523140 173 -STPGEKALGFRMSETLMtiikpyfLRR 199
Cdd:cd18010  193 sGSSNLEELHLLLLATIM-------IRR 213
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
330-469 9.77e-11

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 64.37  E-value: 9.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 330 ESGKLVFLFALLERLRQE--GHRTLIFAHYRKVLDIIERILGNRGFKVMRL--------DGTITQiTERERRIERFqKDK 399
Cdd:COG1111  333 EHPKLSKLREILKEQLGTnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFvgqaskegDKGLTQ-KEQIEILERF-RAG 410

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 400 RYSVfLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVViyrLITCGTVEEKIYRR 469
Cdd:COG1111  411 EFNV-LVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGRVVV---LIAKGTRDEAYYWS 476
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 399-454 6.52e-10

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 55.40  E-value: 6.52e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 575523140 399 KRYSVFLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIY 454
Cdd:cd18785   20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 20-144 2.69e-08

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 54.66  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  20 LLVMPTSLITNWTKEFAKWTP-GMRVKEFHG--TSKMERTRNLEKVQRRGgVIITTYTML---MNNWQQLASYRGREFTW 93
Cdd:cd18070   74 LIVCPSAILAQWLDEINRHVPsSLKVLTYQGvkKDGALASPAPEILAEYD-IVVTTYDVLrteLHYAEANRSNRRRRRQK 152

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 575523140  94 DYM--------------ILDEAHKIKTSTTKTAKSAHAVPSTNRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18070  153 RYEappsplvlvewwrvCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSF 217
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 3-167 5.21e-08

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 53.51  E-value: 5.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   3 VITFLSGMYDCELVKHCLLVMPTSLITN-WTKEFAKWT--PGMRVKEFHGTSKmERTRNLEKVQrrggviiTTYTMLMNN 79
Cdd:cd18013   32 TLTALSDLQLDDFTRRVLVIAPLRVARStWPDEVEKWNhlRNLTVSVAVGTER-QRSKAANTPA-------DLYVINREN 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  80 WQQLASYRGREFTWDYMILDEAHKIKTSTTKTAKSAHAV-PSTNR-VLLTGTPVQNNLKEMWALFDFACHGTLLG-TAKT 156
Cdd:cd18013  104 LKWLVNKSGDPWPFDMVVIDELSSFKSPRSKRFKALRKVrPVIKRlIGLTGTPSPNGLMDLWAQIALLDQGERLGrSITA 183

                        170
                 ....*....|.
gi 575523140 157 FKAEYENPITR 167
Cdd:cd18013  184 YRERWFDPDKR 194
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
310-474 8.24e-08

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 54.65  E-value: 8.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 310 SDSETDAHTIDNVSDDALIS-ESGKLVFLFALLERLRqEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTiTQITER 388
Cdd:COG1061  267 TDERAEYDALSERLREALAAdAERKDKILRELLREHP-DDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGD-TPKKER 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 389 ERRIERFQKDKRysVFLLTTQVGGVGITLTGADRVVIYDPSWNPATDAQAVDRAYRIGQT-ENVVIYRLITCGT-VEEKI 466
Cdd:COG1061  345 EEILEAFRDGEL--RILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGkEDALVYDFVGNDVpVLEEL 422


                 ....*...
gi 575523140 467 YRRQVFKD 474
Cdd:COG1061  423 AKDLRDLA 430
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 5-141 1.30e-07

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 51.91  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   5 TFLSGMYDCEL-----VKHCLLVMPTSLITNWTKE-FAKWTPGMRVKEFHGTSKMERTRNleKVQRRGGVIITTYTML-- 76
Cdd:cd18011   31 TIEAGLIIKELllrgdAKRVLILCPASLVEQWQDElQDKFGLPFLILDRETAAQLRRLIG--NPFEEFPIVIVSLDLLkr 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 575523140  77 MNNWQQLASyrgrEFTWDYMILDEAHKI-------KTSTTKTAKS-AHAVPstNRVLLTGTPVQNNLKEMWAL 141
Cdd:cd18011  109 SEERRGLLL----SEEWDLVVVDEAHKLrnsgggkETKRYKLGRLlAKRAR--HVLLLTATPHNGKEEDFRAL 175
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 16-130 5.98e-06

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 46.14  E-value: 5.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  16 VKHCLLVMPT-SLITNWTKEFAKWTPGMRVKEFHGTSKMERTRNLekvqrrggVIITTYTMLMNnwqqlASYRGREFT-- 92
Cdd:cd17926   44 ELRTLIVVPTdALLDQWKERFEDFLGDSSIGLIGGGKKKDFDDAN--------VVVATYQSLSN-----LAEEEKDLFdq 110

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 575523140  93 WDYMILDEAHKIktsTTKTAKSAHAVPSTNRVL-LTGTP 130
Cdd:cd17926  111 FGLLIVDEAHHL---PAKTFSEILKELNAKYRLgLTATP 146
HDA2-3 pfam11496
Class II histone deacetylase complex subunits 2 and 3; This family of class II histone ...
 327-463 1.77e-05

Class II histone deacetylase complex subunits 2 and 3; This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 in Swiss:Q10432. These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus.


Pssm-ID: 402894  Cd Length: 281  Bit Score: 46.55  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  327 LISESGKLVFLFALL----ERLRQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTITQITERERRIERFQKDKRYS 402
Cdd:pfam11496  85 LAYTSGKFLVLNDLVnlliERDRKEPINVAIVARSGKTLDLVEALLLGKGLSYKRYSGEMLYGENKKVSDSGNKKIHSTT 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  403 VFLLTTqvggvGITLT---------GADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVE 463
Cdd:pfam11496 165 CHLLSS-----TGQLTnddsllenyKFDLIIAFDSSVDTSSPSVEHLRTQNRRKGNLAPIIRLVVINSIE 229
DEXHc_XPB cd18029
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ...
 7-102 6.80e-05

DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350787 [Multi-domain]  Cd Length: 169  Bit Score: 43.44  E-value: 6.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140   7 LSGMYDCELVKHCLLVMPTSLIT--NWTKEFAKWT--PGMRVKEFHGTSKmERTRNlekvqrrGGVIITTYTMLMN---- 78
Cdd:cd18029   41 LVGITAACTIKKSTLVLCTSAVSveQWRRQFLDWTtiDDEQIGRFTSDKK-EIFPE-------AGVTVSTYSMLANtrkr 112

                         90       100
                 ....*....|....*....|....*
gi 575523140  79 NWQ-QLASYRGREFTWDYMILDEAH 102
Cdd:cd18029  113 SPEsEKFMEFITEREWGLIILDEVH 137
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
338-448 1.04e-04

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 44.75  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140 338 FALLERL--RQEGHRTLIFAHYRKVLDIIERILGNRGFKVMRLDGTITQiTERERRIERFqKDKRYSVfLLTTQVGGVGI 415
Cdd:COG0513  229 LELLRRLlrDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQ-GQRERALDAF-RNGKIRV-LVATDVAARGI 305

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 575523140 416 TLTGADRVVIYDPSWNPATdaqavdraY--RIGQT 448
Cdd:COG0513  306 DIDDVSHVINYDLPEDPED--------YvhRIGRT 332
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
16-131 2.04e-04

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 43.86  E-value: 2.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140  16 VKHCLLVMPT-SLITNWTKEFAKWTPGmrvKEFHGTSKmertrnlekvQRRGGVIITTYTMLMNNwQQLASYRGReftWD 94
Cdd:COG1061  127 GKRVLVLVPRrELLEQWAEELRRFLGD---PLAGGGKK----------DSDAPITVATYQSLARR-AHLDELGDR---FG 189

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 575523140  95 YMILDEAHKIKTSTTKtaKSAHAVPSTNRVLLTGTPV 131
Cdd:COG1061  190 LVIIDEAHHAGAPSYR--RILEAFPAAYRLGLTATPF 224
rad25 TIGR00603
DNA repair helicase rad25; All proteins in this family for which functions are known are ...
 7-104 3.53e-03

DNA repair helicase rad25; All proteins in this family for which functions are known are DNA-DNA helicases used for the initiation of nucleotide excision repair and transacription as part of the TFIIH complex.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273168 [Multi-domain]  Cd Length: 732  Bit Score: 40.17  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523140    7 LSGMYDCELVKHCLLVMPTSLIT--NWTKEFAKWT---PGMrVKEFHGTSKmertrnlEKVQRRGGVIITTYTMLMNNWQ 81
Cdd:TIGR00603 288 LVGVTAACTVKKSCLVLCTSAVSveQWKQQFKMWStidDSQ-ICRFTSDAK-------ERFHGEAGVVVSTYSMVAHTGK 359

                          90       100       110
                  ....*....|....*....|....*....|..
gi 575523140   82 QlaSY---------RGREftWDYMILDEAHKI 104
Cdd:TIGR00603 360 R--SYesekvmewlTNRE--WGLILLDEVHVV 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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