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Conserved domains on  [gi|575523132|gb|AHG97943|]
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Plk-interacting checkpoint helicase, partial [Lepomis miniatus]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11425670)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

CATH:  1.20.1320.20|3.40.50.300
EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0004386|GO:0005524
PubMed:  20206133|20225155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 1-487 2.33e-127

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 386.12  E-value: 2.33e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSkgERTRNLEKVqRRGGVVITTYTMLINNW 80
Cdd:COG0553  275 IQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR--ERAKGANPF-EDADLVITSYGLLRRDI 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  81 QQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAKTFKAE 160
Cdd:COG0553  352 ELLA-----AVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPG-LLGSLKAFRER 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 161 YENPITRAREKDAtpgekvlgtrmsENLMAIIKPYFLRRTKAEVQKNkmkgthpsndeysdnkdgqvqnspkesgavmpt 240
Cdd:COG0553  426 FARPIEKGDEEAL------------ERLRRLLRPFLLRRTKEDVLKD--------------------------------- 460

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 241 LTRKNDLIVWTYLSSAQEDIYRQFISL--DHIKELLMTSR--SPLAELTILKKLCDHPRLLsaaaiaklgLDEntaesqq 316
Cdd:COG0553  461 LPEKTEETLYVELTPEQRALYEAVLEYlrRELEGAEGIRRrgLILAALTRLRQICSHPALL---------LEE------- 524

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 317 sddtetdahsianvsDDTLISESGKLVFLFALLERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTiTQIAER 396
Cdd:COG0553  525 ---------------GAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGG-TSAEER 588

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 397 ERRITEFQTDKRYSVFLLTTQVGGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYR 476
Cdd:COG0553  589 DELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILE 668

                        490
                 ....*....|.
gi 575523132 477 RQVFKDSLIRQ 487
Cdd:COG0553  669 LLEEKRALAES 679
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 1-487 2.33e-127

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 386.12  E-value: 2.33e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSkgERTRNLEKVqRRGGVVITTYTMLINNW 80
Cdd:COG0553  275 IQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR--ERAKGANPF-EDADLVITSYGLLRRDI 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  81 QQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAKTFKAE 160
Cdd:COG0553  352 ELLA-----AVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPG-LLGSLKAFRER 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 161 YENPITRAREKDAtpgekvlgtrmsENLMAIIKPYFLRRTKAEVQKNkmkgthpsndeysdnkdgqvqnspkesgavmpt 240
Cdd:COG0553  426 FARPIEKGDEEAL------------ERLRRLLRPFLLRRTKEDVLKD--------------------------------- 460

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 241 LTRKNDLIVWTYLSSAQEDIYRQFISL--DHIKELLMTSR--SPLAELTILKKLCDHPRLLsaaaiaklgLDEntaesqq 316
Cdd:COG0553  461 LPEKTEETLYVELTPEQRALYEAVLEYlrRELEGAEGIRRrgLILAALTRLRQICSHPALL---------LEE------- 524

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 317 sddtetdahsianvsDDTLISESGKLVFLFALLERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTiTQIAER 396
Cdd:COG0553  525 ---------------GAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGG-TSAEER 588

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 397 ERRITEFQTDKRYSVFLLTTQVGGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYR 476
Cdd:COG0553  589 DELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILE 668

                        490
                 ....*....|.
gi 575523132 477 RQVFKDSLIRQ 487
Cdd:COG0553  669 LLEEKRALAES 679
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 1-199 1.39e-123

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 360.53  E-value: 1.39e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERTRNLEKVQRRGGVVITTYTMLINNW 80
Cdd:cd18001   34 VQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVFHGTSKKERERNLERIQRGGGVLLTTYGMVLSNT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  81 QQLSSYQGTEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGTLLGTAKTFKAE 160
Cdd:cd18001  114 EQLSADDHDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKME 193

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 575523132 161 YENPITRAREKDATPGEKVLGTRMSENLMAIIKPYFLRR 199
Cdd:cd18001  194 FENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 24-487 1.20e-65

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 228.92  E-value: 1.20e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   24 PTSLITNWTKEFAKWTPGLRVKEFHGTSKgERTRNLEKVQRRGG--VVITTYTMLINNWQQLSsyqgtEFTWDYMILDEA 101
Cdd:PLN03142  227 PKSTLGNWMNEIRRFCPVLRAVKFHGNPE-ERAHQREELLVAGKfdVCVTSFEMAIKEKTALK-----RFSWRYIIIDEA 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  102 HKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGTAKTFKAEYENpitrarEKDATPGEKVlg 181
Cdd:PLN03142  301 HRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLP-EIFSSAETFDEWFQI------SGENDQQEVV-- 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  182 trmsENLMAIIKPYFLRRTKAEVQKNkmkgthpsndeysdnkdgqvqnspkesgavmptLTRKNDLIVWTYLSSAQEDIY 261
Cdd:PLN03142  372 ----QQLHKVLRPFLLRRLKSDVEKG---------------------------------LPPKKETILKVGMSQMQKQYY 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  262 RQFISLDhiKELLMT--SRSPLAELTI-LKKLCDHPRLLSAAAIAKlgldentaesqqsddtetdahsiANVSDDTLISE 338
Cdd:PLN03142  415 KALLQKD--LDVVNAggERKRLLNIAMqLRKCCNHPYLFQGAEPGP-----------------------PYTTGEHLVEN 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  339 SGKLVFLFALLERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTiTQIAERERRITEFqtDKRYS---VFLLT 415
Cdd:PLN03142  470 SGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGN-TGGEDRDASIDAF--NKPGSekfVFLLS 546

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 575523132  416 TQVGGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYRRQVFK---DSLIRQ 487
Cdd:PLN03142  547 TRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKlalDALVIQ 621
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 1-297 2.44e-51

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 176.33  E-value: 2.44e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132    1 IQVISFLSGMYDNELVKH--ALLSMPTSLITNWTKEFAKWT--PGLRVKEFHGT-SKGERTRNLEKVQRRGGVVITTYTM 75
Cdd:pfam00176  32 LQTISLLLYLKHVDKNWGgpTLIVVPLSLLHNWMNEFERWVspPALRVVVLHGNkRPQERWKNDPNFLADFDVVITTYET 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   76 LINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAK 155
Cdd:pfam00176 112 LRKHKELLKKVH-----WHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPG-PFGSLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  156 TFKAEYENPITRAREKDatpgekvlgtrMSENLMAIIKPYFLRRTKAEVQKNkmkgthpsndeysdnkdgqvqnspkesg 235
Cdd:pfam00176 186 TFRNWFDRPIERGGGKK-----------GVSRLHKLLKPFLLRRTKKDVEKS---------------------------- 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 575523132  236 avmptLTRKNDLIVWTYLSSAQEDIYRQFISLDHIKELL------MTSRSPLAELTILKKLCDHPRLL 297
Cdd:pfam00176 227 -----LPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKtgeggrEIKASLLNILMRLRKICNHPGLI 289
HELICc smart00490
helicase superfamily c-terminal domain;
370-454 4.46e-23

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 92.66  E-value: 4.46e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   370 DIIERILGHRGFKVMRLDGTITQiAERERRITEFQTDKRysVFLLTTQVGGVGITLTAADRVVIYDPSWNPATDAQAVDR 449
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQ-EEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77


                   ....*
gi 575523132   450 AYRIG 454
Cdd:smart00490  78 AGRAG 82
 
Name Accession Description Interval E-value
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 1-487 2.33e-127

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 386.12  E-value: 2.33e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSkgERTRNLEKVqRRGGVVITTYTMLINNW 80
Cdd:COG0553  275 IQALALLLELKERGLARPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTR--ERAKGANPF-EDADLVITSYGLLRRDI 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  81 QQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAKTFKAE 160
Cdd:COG0553  352 ELLA-----AVDWDLVILDEAQHIKNPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPG-LLGSLKAFRER 425

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 161 YENPITRAREKDAtpgekvlgtrmsENLMAIIKPYFLRRTKAEVQKNkmkgthpsndeysdnkdgqvqnspkesgavmpt 240
Cdd:COG0553  426 FARPIEKGDEEAL------------ERLRRLLRPFLLRRTKEDVLKD--------------------------------- 460

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 241 LTRKNDLIVWTYLSSAQEDIYRQFISL--DHIKELLMTSR--SPLAELTILKKLCDHPRLLsaaaiaklgLDEntaesqq 316
Cdd:COG0553  461 LPEKTEETLYVELTPEQRALYEAVLEYlrRELEGAEGIRRrgLILAALTRLRQICSHPALL---------LEE------- 524

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 317 sddtetdahsianvsDDTLISESGKLVFLFALLERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTiTQIAER 396
Cdd:COG0553  525 ---------------GAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGG-TSAEER 588

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 397 ERRITEFQTDKRYSVFLLTTQVGGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYR 476
Cdd:COG0553  589 DELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILE 668

                        490
                 ....*....|.
gi 575523132 477 RQVFKDSLIRQ 487
Cdd:COG0553  669 LLEEKRALAES 679
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
 1-199 1.39e-123

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 360.53  E-value: 1.39e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERTRNLEKVQRRGGVVITTYTMLINNW 80
Cdd:cd18001   34 VQICAFLSGMFDSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKVFHGTSKKERERNLERIQRGGGVLLTTYGMVLSNT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  81 QQLSSYQGTEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGTLLGTAKTFKAE 160
Cdd:cd18001  114 EQLSADDHDEFKWDYVILDEGHKIKNSKTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKME 193

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 575523132 161 YENPITRAREKDATPGEKVLGTRMSENLMAIIKPYFLRR 199
Cdd:cd18001  194 FENPITRGRDKDATQGEKALGSEVAENLRQIIKPYFLRR 232
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
 24-487 1.20e-65

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 228.92  E-value: 1.20e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   24 PTSLITNWTKEFAKWTPGLRVKEFHGTSKgERTRNLEKVQRRGG--VVITTYTMLINNWQQLSsyqgtEFTWDYMILDEA 101
Cdd:PLN03142  227 PKSTLGNWMNEIRRFCPVLRAVKFHGNPE-ERAHQREELLVAGKfdVCVTSFEMAIKEKTALK-----RFSWRYIIIDEA 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  102 HKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGTAKTFKAEYENpitrarEKDATPGEKVlg 181
Cdd:PLN03142  301 HRIKNENSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLP-EIFSSAETFDEWFQI------SGENDQQEVV-- 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  182 trmsENLMAIIKPYFLRRTKAEVQKNkmkgthpsndeysdnkdgqvqnspkesgavmptLTRKNDLIVWTYLSSAQEDIY 261
Cdd:PLN03142  372 ----QQLHKVLRPFLLRRLKSDVEKG---------------------------------LPPKKETILKVGMSQMQKQYY 414

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  262 RQFISLDhiKELLMT--SRSPLAELTI-LKKLCDHPRLLSAAAIAKlgldentaesqqsddtetdahsiANVSDDTLISE 338
Cdd:PLN03142  415 KALLQKD--LDVVNAggERKRLLNIAMqLRKCCNHPYLFQGAEPGP-----------------------PYTTGEHLVEN 469

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  339 SGKLVFLFALLERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTiTQIAERERRITEFqtDKRYS---VFLLT 415
Cdd:PLN03142  470 SGKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGN-TGGEDRDASIDAF--NKPGSekfVFLLS 546

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 575523132  416 TQVGGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLITCGTVEEKIYRRQVFK---DSLIRQ 487
Cdd:PLN03142  547 TRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKlalDALVIQ 621
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 339-465 1.46e-61

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 197.70  E-value: 1.46e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 339 SGKLVFLFALLERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTiTQIAERERRITEFQTDKRYSVFLLTTQV 418
Cdd:cd18793   10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGS-TSSKERQKLVDRFNEDPDIRVFLLSTKA 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 575523132 419 GGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLI 465
Cdd:cd18793   89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
 1-201 5.11e-58

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 191.24  E-value: 5.11e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGT-SKGERTRNLEKVQrrggVVITTYTMLinn 79
Cdd:cd18012   38 LQTLALLLSRKEEGRKGPSLVVAPTSLIYNWEEEAAKFAPELKVLVIHGTkRKREKLRALEDYD----LVITSYGLL--- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  80 WQQLSSYQgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAKTFKA 159
Cdd:cd18012  111 RRDIELLK--EVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPG-LLGSYKRFKK 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 575523132 160 EYENPITRAREKDAtpgekvlgtrmSENLMAIIKPYFLRRTK 201
Cdd:cd18012  188 RFAKPIEKDGDEEA-----------LEELKKLISPFILRRLK 218
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
 1-145 2.33e-51

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 172.75  E-value: 2.33e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGM-YDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERTRNLEKVQRRGGVVITTYTMLINN 79
Cdd:cd17919   34 LQAIAFLAYLlKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVVYHGSQRERAQIRAKEKLDKFDVVLTTYETLRRD 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 575523132  80 WQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFA 145
Cdd:cd17919  114 KASLRK-----FRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTPLQNNLEELWALLDFL 174
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
 1-297 2.44e-51

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 176.33  E-value: 2.44e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132    1 IQVISFLSGMYDNELVKH--ALLSMPTSLITNWTKEFAKWT--PGLRVKEFHGT-SKGERTRNLEKVQRRGGVVITTYTM 75
Cdd:pfam00176  32 LQTISLLLYLKHVDKNWGgpTLIVVPLSLLHNWMNEFERWVspPALRVVVLHGNkRPQERWKNDPNFLADFDVVITTYET 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   76 LINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAK 155
Cdd:pfam00176 112 LRKHKELLKKVH-----WHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGTPLQNNLEELWALLNFLRPG-PFGSLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  156 TFKAEYENPITRAREKDatpgekvlgtrMSENLMAIIKPYFLRRTKAEVQKNkmkgthpsndeysdnkdgqvqnspkesg 235
Cdd:pfam00176 186 TFRNWFDRPIERGGGKK-----------GVSRLHKLLKPFLLRRTKKDVEKS---------------------------- 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 575523132  236 avmptLTRKNDLIVWTYLSSAQEDIYRQFISLDHIKELL------MTSRSPLAELTILKKLCDHPRLL 297
Cdd:pfam00176 227 -----LPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKtgeggrEIKASLLNILMRLRKICNHPGLI 289
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
 1-199 8.37e-45

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 157.45  E-value: 8.37e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFL-----SGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEF---HGTSKGERTRNLEKVQRRGGVVITT 72
Cdd:cd18004   39 LQAIALVwtllkQGPYGKPTAKKALIVCPSSLVGNWKAEFDKWLGLRRIKVVtadGNAKDVKASLDFFSSASTYPVLIIS 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  73 YTMLINNWQQLSsyQGTEFtwDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLG 152
Cdd:cd18004  119 YETLRRHAEKLS--KKISI--DLLICDEGHRLKNSESKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPG-ILG 193

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 575523132 153 TAKTFKAEYENPITRAREKDATPGEKVLGTRMSENLMAIIKPYFLRR 199
Cdd:cd18004  194 SLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFILRR 240
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
 1-199 1.03e-38

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 140.98  E-value: 1.03e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMY---------------------DNELVKHALLSMPTSLITNWTKEFAKWTpGLRVKEFHGtskGERTRNL 59
Cdd:cd18005   34 VQVIAFLAAVLgktgtrrdrennrprfkkkppASSAKKPVLIVAPLSVLYNWKDELDTWG-HFEVGVYHG---SRKDDEL 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  60 EKVQRRGG--VVITTYTMLINNWQQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKE 137
Cdd:cd18005  110 EGRLKAGRleVVVTTYDTLRRCIDSLN-----SINWSAVIADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKE 184

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 575523132 138 MWALFDFACQGtLLGTAKTFKAEYENPITRAREKDATPGEKVLGTRMSENLMAIIKPYFLRR 199
Cdd:cd18005  185 LWCLLDWAVPG-ALGSRSQFKKHFSEPIKRGQRHTATARELRLGRKRKQELAVKLSKFFLRR 245
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
 19-199 4.97e-38

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 139.02  E-value: 4.97e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  19 ALLSMPTSLITNWTKEFAKWTP--GLRVKEFHGTSKGERTrnLEKVQRRGGVVITTYTMLINNWQQLssyqgTEFTWDYM 96
Cdd:cd17999   58 SLVVCPPTLVGHWVAEIKKYFPnaFLKPLAYVGPPQERRR--LREQGEKHNVIVASYDVLRNDIEVL-----TKIEWNYC 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  97 ILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAKTFKAEYENPITRAREKDATPG 176
Cdd:cd17999  131 VLDEGHIIKNSKTKLSKAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPG-YLGTEKQFQRRFLKPILASRDSKASAK 209

                        170       180
                 ....*....|....*....|...
gi 575523132 177 EKVLGTRMSENLMAIIKPYFLRR 199
Cdd:cd17999  210 EQEAGALALEALHKQVLPFLLRR 232
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
 1-201 5.93e-38

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 138.67  E-value: 5.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTsKGERTRNLEKVQRRGG------VVITTYT 74
Cdd:cd18009   37 IQTIALLAHLRERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPVLLYHGT-KEERERLRKKIMKREGtlqdfpVVVTSYE 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  75 MLINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGTA 154
Cdd:cd18009  116 IAMRDRKALQHYA-----WKYLIVDEGHRLKNLNCRLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLP-DVFDDL 189

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 575523132 155 KTF-----------KAEYENPITRAREKDatpgekvlgtrMSENLMAIIKPYFLRRTK 201
Cdd:cd18009  190 SSFeswfdfsslsdNAADISNLSEEREQN-----------IVHMLHAILKPFLLRRLK 236
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
 1-144 4.69e-37

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 135.14  E-value: 4.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGM-YDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERTRN-----------LEKVQRRGGV 68
Cdd:cd18000   34 IQIIAFLAALhHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVVLHSSGSGTGSEEklgsierksqlIRKVVGDGGI 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 575523132  69 VITTYTMLINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18000  114 LITTYEGFRKHKDLLLNHN-----WQYVILDEGHKIRNPDAEITLACKQLRTPHRLILSGTPIQNNLKELWSLFDF 184
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
 2-177 4.81e-36

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 133.57  E-value: 4.81e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   2 QVISFL-SGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRV-------KEFHGTSKGeRTRNLEKVQRRGGVVITTY 73
Cdd:cd18007   42 QVITFLhTYLAAAPRRSRPLVLCPASTLYNWEDEFKKWLPPDLRpllvlvsLSASKRADA-RLRKINKWHKEGGVLLIGY 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  74 TM---LINNWQQLSSYQGTEFTW------DYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18007  121 ELfrnLASNATTDPRLKQEFIAAlldpgpDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDF 200

                        170       180       190
                 ....*....|....*....|....*....|...
gi 575523132 145 AcQGTLLGTAKTFKAEYENPITRAREKDATPGE 177
Cdd:cd18007  201 A-RPKYLGTLKEFKKKFVKPIEAGQCVDSTEED 232
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
 15-199 5.72e-34

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 128.04  E-value: 5.72e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  15 LVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFhGTSKGERTRNLEKVQRRGgVVITTYTMLINNWQQLSSYQgteftWD 94
Cdd:cd18066   59 VIKRALIVTPGSLVKNWKKEFQKWLGSERIKVF-TVDQDHKVEEFIASPLYS-VLIISYEMLLRSLDQISKLN-----FD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  95 YMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFaCQGTLLGTAKTFKAEYENPITRAREKDAT 174
Cdd:cd18066  132 LVICDEGHRLKNTSIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDF-VNPGILGSLSTYRKVYEEPIVRSREPTAT 210

                        170       180
                 ....*....|....*....|....*
gi 575523132 175 PGEKVLGTRMSENLMAIIKPYFLRR 199
Cdd:cd18066  211 PEEKKLGEARAAELTRLTGLFILRR 235
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
 1-201 3.43e-33

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 125.51  E-value: 3.43e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGM--YDNELVKHaLLSMPTSLITNWTKEFAKWTPGLRVKEFHGTsKGERTRNLEKVQRRG--GVVITTYTML 76
Cdd:cd17997   37 LQTISLLGYLkhYKNINGPH-LIIVPKSTLDNWMREFKRWCPSLRVVVLIGD-KEERADIIRDVLLPGkfDVCITSYEMV 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  77 INNWQQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFacqgtLL----G 152
Cdd:cd17997  115 IKEKTVLK-----KFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNF-----LLpdvfT 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 575523132 153 TAKTFKAEYENpitrarEKDATPGEKVLgtrmsENLMAIIKPYFLRRTK 201
Cdd:cd17997  185 SSEDFDEWFNV------NNCDDDNQEVV-----QRLHKVLRPFLLRRIK 222
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
 1-199 4.02e-33

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 125.44  E-value: 4.02e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKH-ALLSMPTSLITNWTKEFAKWTPgLRVKEFHGTSKGERTRNLEKVQRRGG------------ 67
Cdd:cd17995   34 IQSIAFLEHLYQVEGIRGpFLVIAPLSTIPNWQREFETWTD-MNVVVYHGSGESRQIIQQYEMYFKDAqgrkkkgvykfd 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  68 VVITTYTMLINNWQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQ 147
Cdd:cd17995  113 VLITTYEMVIADAEELRK-----IPWRVVVVDEAHRLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEP 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 575523132 148 GTlLGTAKTFKAEYenpitrareKDATPGEKVlgtrmsENLMAIIKPYFLRR 199
Cdd:cd17995  188 EK-FPSSEEFLEEF---------GDLKTAEQV------EKLQALLKPYMLRR 223
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
 1-201 9.45e-32

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 121.71  E-value: 9.45e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDnelVKHA----LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTsKGERtRNLEKVQRRG--GVVITTYT 74
Cdd:cd17996   37 IQTISLITYLME---KKKNngpyLVIVPLSTLSNWVSEFEKWAPSVSKIVYKGT-PDVR-KKLQSQIRAGkfNVLLTTYE 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  75 MLINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSAS-AIPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGT 153
Cdd:cd17996  112 YIIKDKPLLSKIK-----WKYMIIDEGHRMKNAQSKLTQTLNtYYHARYRLLLTGTPLQNNLPELWALLNFLLP-KIFKS 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575523132 154 AKTFKAEYENPITRAREKDA---TPGEKVLGTRmseNLMAIIKPYFLRRTK 201
Cdd:cd17996  186 CKTFEQWFNTPFANTGEQVKielNEEETLLIIR---RLHKVLRPFLLRRLK 233
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
 1-199 7.77e-31

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 118.99  E-value: 7.77e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELV--KHaLLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKgERtrnleKVQRRG-------GVVIT 71
Cdd:cd18003   34 IQTIALLAHLACEKGNwgPH-LIVVPTSVMLNWEMEFKRWCPGFKILTYYGSAK-ER-----KLKRQGwmkpnsfHVCIT 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  72 TYTMLINNWQQLssyqgTEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLL 151
Cdd:cd18003  107 SYQLVVQDHQVF-----KRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMP-HIF 180

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 575523132 152 GTAKTFKAEYENPITRAREKDATPGEKVLgtrmsENLMAIIKPYFLRR 199
Cdd:cd18003  181 QSHQEFKEWFSNPLTAMSEGSQEENEELV-----RRLHKVLRPFLLRR 223
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
 15-199 8.25e-28

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 111.41  E-value: 8.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  15 LVKHALLSMPTSLITNWTKEFAKWT-PGLRVKEFHGTSKGERTRNLEKVQRRGGVVITTYTMLINnWQQLSSYQGTEFTW 93
Cdd:cd18067   58 EIDKAIVVSPSSLVKNWANELGKWLgGRLQPLAIDGGSKKEIDRKLVQWASQQGRRVSTPVLIIS-YETFRLHVEVLQKG 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  94 D--YMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGtLLGTAKTFKAEYENPITRAREK 171
Cdd:cd18067  137 EvgLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPG-ILGTAAEFKKNFELPILKGRDA 215

                        170       180
                 ....*....|....*....|....*...
gi 575523132 172 DATPGEKVLGTRMSENLMAIIKPYFLRR 199
Cdd:cd18067  216 DASEKERQLGEEKLQELISIVNRCIIRR 243
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
 1-144 8.89e-28

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 109.40  E-value: 8.89e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGtSKGERTRNLEKVQRRGG---VVITTYTMLI 77
Cdd:cd17998   34 IQVIAFLAYLKEIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEPYYG-SQEERKHLRYDILKGLEdfdVIVTTYNLAT 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 575523132  78 NNWQQLSSYQGTEFtwDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd17998  113 SNPDDRSFFKRLKL--NYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNF 177
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
 1-199 1.03e-27

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 110.14  E-value: 1.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYdNELVKHA--LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERT-RNLEKVQRRG-----GVVITT 72
Cdd:cd17993   35 VQTISFLSYLF-HSQQQYGpfLVVVPLSTMPAWQREFAKWAPDMNVIVYLGDIKSRDTiREYEFYFSQTkklkfNVLLTT 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  73 YTMLINNWQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQGTLlg 152
Cdd:cd17993  114 YEIILKDKAFLGS-----IKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKF-- 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 575523132 153 takTFKAEYENPITRAREKDAtpgekvlgtrmsENLMAIIKPYFLRR 199
Cdd:cd17993  187 ---DIWEEFEEEHDEEQEKGI------------ADLHKELEPFILRR 218
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 340-454 5.25e-27

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 104.60  E-value: 5.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  340 GKLVFLFALLERlrEEGHRTLVFAHYRKVLDIiERILGHRGFKVMRLDGTITQiAERERRITEFQTDKRysVFLLTTQVG 419
Cdd:pfam00271   1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQ-EEREEILEDFRKGKI--DVLVATDVA 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 575523132  420 GVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIG 454
Cdd:pfam00271  75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
 24-199 1.14e-26

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 108.14  E-value: 1.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  24 PTSLITNWTKEFAK--WTPGLRVKEFHGTSKGERTRNLEKVqrrgGVVITTYTMLINNWQQLSSYQGT-----------E 90
Cdd:cd18008   70 PLSLLSQWKDEIEKhtKPGSLKVYVYHGSKRIKSIEELSDY----DIVITTYGTLASEFPKNKKGGGRdskekeasplhR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  91 FTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFacqgtllgtaKTFKAEYENPITRARE 170
Cdd:cd18008  146 IRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRF----------LRVEPFGDYPWFNSDI 215

                        170       180
                 ....*....|....*....|....*....
gi 575523132 171 KDATPGEKVLGTrmsENLMAIIKPYFLRR 199
Cdd:cd18008  216 SKPFSKNDRKAL---ERLQALLKPILLRR 241
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
 1-175 7.51e-26

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 105.74  E-value: 7.51e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNEL---VKHALLSMPTSLITNWTKEFAKWTPGLR------VKEFHG-TSKGERTRNLEKVQRRGGVVI 70
Cdd:cd18068   43 LQVVTFLHTVLLCEKlenFSRVLVVCPLNTVLNWLNEFEKWQEGLKdeekieVNELATyKRPQERSYKLQRWQEEGGVMI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  71 TTYTMLINNWQQ----LSSYQGTEFTW-------DYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMW 139
Cdd:cd18068  123 IGYDMYRILAQErnvkSREKLKEIFNKalvdpgpDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYH 202

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 575523132 140 ALFDFACQGtLLGTAKTFKAEYENPITRAREKDATP 175
Cdd:cd18068  203 CMVNFVKPN-LLGTIKEFRNRFVNPIQNGQCADSTL 237
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
 1-180 1.19e-25

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 104.90  E-value: 1.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKW------TPGLRVKEF--HGTSKGERTRN-----LEKVQRRGG 67
Cdd:cd18069   43 LQVISFLDVLLRHTGAKTVLAIVPVNTLQNWLSEFNKWlpppeaLPNVRPRPFkvFILNDEHKTTAarakvIEDWVKDGG 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  68 VVITTYTMLINNwqqlssyQGTeftwDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQ 147
Cdd:cd18069  123 VLLMGYEMFRLR-------PGP----DVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRP 191

                        170       180       190
                 ....*....|....*....|....*....|...
gi 575523132 148 GtLLGTAKTFKAEYENPITRAREKDATPGEKVL 180
Cdd:cd18069  192 D-FLGTRQEFSNMFERPILNGQCVDSTPQDVKL 223
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
 1-199 7.78e-25

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 102.58  E-value: 7.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSM-PTSLITNWTKEFAKWTPGLRVKEFHGTSKGERT-------RNLEKVQRRGGVVITT 72
Cdd:cd18002   34 VQSIAVLAHLAEEHNIWGPFLVIaPASTLHNWQQEISRFVPQFKVLPYWGNPKDRKVlrkfwdrKNLYTRDAPFHVVITS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  73 YTMLINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFaCQGTLLG 152
Cdd:cd18002  114 YQLVVQDEKYFQRVK-----WQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRLLLTGTPIQNSMAELWALLHF-IMPTLFD 187

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 575523132 153 TAKTFKAEYENPITRAREKDATPGEKVLgtrmsENLMAIIKPYFLRR 199
Cdd:cd18002  188 SHDEFNEWFSKDIESHAENKTGLNEHQL-----KRLHMILKPFMLRR 229
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
 1-207 1.36e-24

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 102.44  E-value: 1.36e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGM--YDNELVKHALLsMPTSLITNWTKEFAKWTPGLRVKEFHGtSKGERTRNLEKVQRRG--GVVITTYTML 76
Cdd:cd18064   49 LQTISLLGYMkhYRNIPGPHMVL-VPKSTLHNWMAEFKRWVPTLRAVCLIG-DKDQRAAFVRDVLLPGewDVCVTSYEML 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  77 InnwQQLSSYQgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGTAKT 156
Cdd:cd18064  127 I---KEKSVFK--KFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLP-DVFNSAED 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 575523132 157 FKAEYENpitrarekdatpgEKVLG-TRMSENLMAIIKPYFLRRTKAEVQKN 207
Cdd:cd18064  201 FDSWFDT-------------NNCLGdQKLVERLHMVLRPFLLRRIKADVEKS 239
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
 1-199 9.07e-24

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 99.69  E-value: 9.07e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMY-DNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERT-RNLEKVQRRG-----GVVITTY 73
Cdd:cd18054   54 IQTISFLSYLFhQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTiREYEWIHSQTkrlkfNALITTY 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  74 TMLINNWQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFacqgtLLGT 153
Cdd:cd18054  134 EILLKDKTVLGS-----INWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHF-----IMPE 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 575523132 154 AKTFKAEYENPITRAREKDatpgekvlgtrmSENLMAIIKPYFLRR 199
Cdd:cd18054  204 KFEFWEDFEEDHGKGRENG------------YQSLHKVLEPFLLRR 237
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
 1-201 2.88e-23

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 98.17  E-value: 2.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGM--YDNELVKHALLsMPTSLITNWTKEFAKWTPGLRVKEFHGtSKGERTRNLEKVQRRG--GVVITTYTML 76
Cdd:cd18065   49 LQTIALLGYLkhYRNIPGPHMVL-VPKSTLHNWMNEFKRWVPSLRAVCLIG-DKDARAAFIRDVMMPGewDVCVTSYEMV 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  77 InnwQQLSSYQgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGTAKT 156
Cdd:cd18065  127 I---KEKSVFK--KFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLP-DVFNSADD 200

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 575523132 157 FKAEYENpitrarekdatpgEKVLG-TRMSENLMAIIKPYFLRRTK 201
Cdd:cd18065  201 FDSWFDT-------------KNCLGdQKLVERLHAVLKPFLLRRIK 233
HELICc smart00490
helicase superfamily c-terminal domain;
370-454 4.46e-23

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 92.66  E-value: 4.46e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   370 DIIERILGHRGFKVMRLDGTITQiAERERRITEFQTDKRysVFLLTTQVGGVGITLTAADRVVIYDPSWNPATDAQAVDR 449
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQ-EEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77


                   ....*
gi 575523132   450 AYRIG 454
Cdd:smart00490  78 AGRAG 82
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
 1-201 5.54e-22

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 95.13  E-value: 5.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHA-LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERTRNLEKVQRRGGVVITTYTMLINN 79
Cdd:cd18063   57 IQTIALITYLMEHKRLNGPyLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKD 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  80 WQQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASA-IPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGTAKTFK 158
Cdd:cd18063  137 KHILA-----KIRWKYMIVDEGHRMKNHHCKLTQVLNThYVAPRRILLTGTPLQNKLPELWALLNFLLP-TIFKSCSTFE 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 575523132 159 AEYENPITRAREK-DATPGEKVLGTRmseNLMAIIKPYFLRRTK 201
Cdd:cd18063  211 QWFNAPFAMTGERvDLNEEETILIIR---RLHKVLRPFLLRRLK 251
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
 1-201 1.77e-21

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 93.57  E-value: 1.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHA-LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKGERTRNLEKVQRRGGVVITTYTMLINN 79
Cdd:cd18062   57 IQTIALITYLMEHKRINGPfLIIVPLSTLSNWVYEFDKWAPSVVKVSYKGSPAARRAFVPQLRSGKFNVLLTTYEYIIKD 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  80 WQQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASA-IPSKHRVLLTGTPVQNNLKEMWALFDFACQgTLLGTAKTFK 158
Cdd:cd18062  137 KQILA-----KIRWKYMIVDEGHRMKNHHCKLTQVLNThYVAPRRLLLTGTPLQNKLPELWALLNFLLP-TIFKSCSTFE 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 575523132 159 AEYENPITRAREK-DATPGEKVLGTRmseNLMAIIKPYFLRRTK 201
Cdd:cd18062  211 QWFNAPFAMTGEKvDLNEEETILIIR---RLHKVLRPFLLRRLK 251
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
 2-199 3.87e-20

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 88.65  E-value: 3.87e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   2 QVISFLSGMYDNELVKHALLSM-PTSLITNWTKEFAKWTPGLRVKEFHGtSKGERT---RNLeKVQRRGGVVITTYTMLI 77
Cdd:cd18006   35 QTISLLWYLAGRLKLLGPFLVLcPLSVLDNWKEELNRFAPDLSVITYMG-DKEKRLdlqQDI-KSTNRFHVLLTTYEICL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  78 NNWQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFaCQGTLLGtaktf 157
Cdd:cd18006  113 KDASFLKS-----FPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSF-IEPNVFP----- 181

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 575523132 158 KAEYENPITRAREKDATPGekvlgtrMSENLMAIIKPYFLRR 199
Cdd:cd18006  182 KDKLDDFIKAYSETDDESE-------TVEELHLLLQPFLLRR 216
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
 20-144 9.21e-20

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 88.31  E-value: 9.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  20 LLSMPTSLITNWTKEFAKWTPG--LRVKEFHGTSKGERTRNLekvqRRGGVVITTYTMLINnwqQLSSYQGTEFT----- 92
Cdd:cd18072   77 LVVCPASLVHQWKNEVESRVASnkLRVCLYHGPNRERIGEVL----RDYDIVITTYSLVAK---EIPTYKEESRSsplfr 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 575523132  93 --WDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18072  150 iaWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKF 203
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
 1-199 1.69e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 87.03  E-value: 1.69e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPgLRVKEFHGT----------------SKGERTRNLEKVQr 64
Cdd:cd18060   34 IQSIAFLQEVYNVGIHGPFLVIAPLSTITNWEREFNTWTE-MNTIVYHGSlasrqmiqqyemyckdSRGRLIPGAYKFD- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  65 rggVVITTYTMLINNWQQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18060  112 ---ALITTFEMILSDCPELR-----EIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHF 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 575523132 145 aCQGTLLGTAKTFKAEYenpitrareKDATPGEKVlgtrmsENLMAIIKPYFLRR 199
Cdd:cd18060  184 -LEPSQFPSESEFLKDF---------GDLKTEEQV------QKLQAILKPMMLRR 222
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
 1-199 1.94e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 87.02  E-value: 1.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPgLRVKEFHGTSKGERT-RNLEKVQR-----------RGGV 68
Cdd:cd18058   34 IQSITFLSEIFLMGIRGPFLIIAPLSTITNWEREFRTWTE-MNAIVYHGSQISRQMiQQYEMYYRdeqgnplsgifKFQV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  69 VITTYTMLINNWQQLSsyqgtEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFaCQG 148
Cdd:cd18058  113 VITTFEMILADCPELK-----KINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNF-LEP 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575523132 149 TLLGTAKTFKAEYENPITRAREKdatpgekvlgtrmseNLMAIIKPYFLRR 199
Cdd:cd18058  187 SQFPSETTFLEEFGDLKTEEQVK---------------KLQSILKPMMLRR 222
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
 1-146 3.57e-19

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 85.57  E-value: 3.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHA-LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSkgertrnlekvqrrggVVITTYTMLINN 79
Cdd:cd17994   34 IQTIVFLYSLYKEGHSKGPfLVSAPLSTIINWEREFEMWAPDFYVVTYVGDH----------------VLLTSYELISID 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 575523132  80 WQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFAC 146
Cdd:cd17994   98 QAILGS-----IDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLT 159
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
 1-199 1.78e-18

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 84.31  E-value: 1.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTPgLRVKEFHGTSKGERTRNLEKVQRRGG------------V 68
Cdd:cd18059   34 IQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWTE-LNVVVYHGSQASRRTIQLYEMYFKDPqgrvikgsykfhA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  69 VITTYTMLINNWQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDFACQG 148
Cdd:cd18059  113 IITTFEMILTDCPELRN-----IPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPS 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575523132 149 TlLGTAKTFKAEYenpitrareKDATPGEKVlgtrmsENLMAIIKPYFLRR 199
Cdd:cd18059  188 R-FPSETTFMQEF---------GDLKTEEQV------QKLQAILKPMMLRR 222
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
 1-199 1.51e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 81.59  E-value: 1.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHALLSMPTSLITNWTKEFAKWTpGLRVKEFHGT----------------SKGERTRNLEKVQr 64
Cdd:cd18061   34 IQSITFLYEILLTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVVYHGSlisrqmiqqyemyfrdSQGRIIRGAYRFQ- 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  65 rggVVITTYTMLINNWQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18061  112 ---AIITTFEMILGGCPELNA-----IDWRCVIIDEAHRLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHF 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 575523132 145 aCQGTLLGTAKTFKAEYenpitrareKDATPGEKVlgtrmsENLMAIIKPYFLRR 199
Cdd:cd18061  184 -LEPLRFPSESTFMQEF---------GDLKTEEQV------QKLQAILKPMMLRR 222
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
 1-144 2.06e-17

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 81.63  E-value: 2.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMY-DNELVKHALLSMPTSLITNWTKEFAKWTPGLRVKEFHG--TSKGE-RTRNLEKVQRRG---GVVITTY 73
Cdd:cd18053   54 IQTISFLNYLFhEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAVVYLGdiNSRNMiRTHEWMHPQTKRlkfNILLTTY 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 575523132  74 TMLINNwqqlSSYQGTeFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18053  134 EILLKD----KSFLGG-LNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHF 199
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
 20-144 1.73e-16

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 78.66  E-value: 1.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  20 LLSMPTSLITNWTKEFAKWT-PG-LRVKEFHGtskGERTRNLEKVQRRGgVVITTYTMLINNWQQLSSYQGTEFTWDYMI 97
Cdd:cd18071   75 LIVCPLSVLSNWETQFEEHVkPGqLKVYTYHG---GERNRDPKLLSKYD-IVLTTYNTLASDFGAKGDSPLHTINWLRVV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 575523132  98 LDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18071  151 LDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSF 197
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
 1-144 4.35e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 74.72  E-value: 4.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHA-LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKG-----ERTRNLEKVQRRGG------- 67
Cdd:cd18056   34 VQTAVFLYSLYKEGHSKGPfLVSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSraiirENEFSFEDNAIRGGkkasrmk 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  68 --------VVITTYTMLINNWQQLSSyqgteFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMW 139
Cdd:cd18056  114 keasvkfhVLLTSYELITIDMAILGS-----IDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELF 188


                 ....*
gi 575523132 140 ALFDF 144
Cdd:cd18056  189 HLLNF 193
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
 1-144 9.83e-15

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 73.51  E-value: 9.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHA-LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSKG-----ERTRNLEKVQRRGG------- 67
Cdd:cd18055   34 IQTIVFLYSLYKEGHTKGPfLVSAPLSTIINWEREFQMWAPDFYVVTYTGDKDSraiirENEFSFDDNAVKGGkkafkmk 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  68 --------VVITTYTMLINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMW 139
Cdd:cd18055  114 reaqvkfhVLLTSYELVTIDQAALGSIR-----WACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELF 188


                 ....*
gi 575523132 140 ALFDF 144
Cdd:cd18055  189 HLLNF 193
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
 1-144 1.72e-14

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 72.79  E-value: 1.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132   1 IQVISFLSGMYDNELVKHA-LLSMPTSLITNWTKEFAKWTPGLRVKEFHGTSK-------------------GERTRNLE 60
Cdd:cd18057   34 VQTIVFLYSLYKEGHSKGPyLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKEsrsvirenefsfednairsGKKVFRMK 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  61 K-VQRRGGVVITTYTMLINNWQQLSSYQgteftWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMW 139
Cdd:cd18057  114 KeAQIKFHVLLTSYELITIDQAILGSIE-----WACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELF 188


                 ....*
gi 575523132 140 ALFDF 144
Cdd:cd18057  189 HLLNF 193
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
 24-199 2.13e-14

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 72.24  E-value: 2.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  24 PTSLITNWTKEFAKWTPGLRVKEFHGTSKGertrNLEKVQRRGGVVITTYTMLINNWQQLSSYQgteftWDYMILDEAHK 103
Cdd:cd18010   51 PSSLRLTWADEIERWLPSLPPDDIQVIVKS----KDGLRDGDAKVVIVSYDLLRRLEKQLLARK-----FKVVICDESHY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 104 IKTSSTKTAKSASAI--PSKHRVLLTGTPVQNNLKEMWALFDfACQGTLLGTAKTFKAEYENPITRAREKDATPgekvlG 181
Cdd:cd18010  122 LKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLD-ALDPKLFGRFHDFGRRYCAAKQGGFGWDYSG-----S 195

                        170
                 ....*....|....*...
gi 575523132 182 TRMSENLMAIIKPYFLRR 199
Cdd:cd18010  196 SNLEELHLLLLATIMIRR 213
DEXDc smart00487
DEAD-like helicases superfamily;
1-142 1.71e-13

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 69.06  E-value: 1.71e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132     1 IQVISFLSGMYDNELVKHALLSMPT-SLITNWTKEFAKWTPGLRVK---EFHGTSKGERTRNLEKvqRRGGVVITTYTML 76
Cdd:smart00487  39 LAALLPALEALKRGKGGRVLVLVPTrELAEQWAEELKKLGPSLGLKvvgLYGGDSKREQLRKLES--GKTDILVTTPGRL 116

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 575523132    77 INNWQQLSSYQGTeftWDYMILDEAHKIKTSSTK---TAKSASAIPSKHRVLLTGTPVQNNLKEMWALF 142
Cdd:smart00487 117 LDLLENDKLSLSN---VDLVILDEAHRLLDGGFGdqlEKLLKLLPKNVQLLLLSATPPEEIENLLELFL 182
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 407-462 4.53e-10

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 55.79  E-value: 4.53e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 575523132 407 KRYSVFLLTTQVGGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIY 462
Cdd:cd18785   20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
338-477 2.90e-09

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 59.36  E-value: 2.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 338 ESGKLVFLFALLERLREE--GHRTLVFAHYRKVLDIIERILGHRGFKVMRL--------DGTITQiAERERRITEFQTDK 407
Cdd:COG1111  333 EHPKLSKLREILKEQLGTnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFvgqaskegDKGLTQ-KEQIEILERFRAGE 411

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 408 rYSVfLLTTQVGGVGITLTAADRVVIYDPSWNPATDAQAVDRAYRIGQTENVViyrLITCGTVEEKIYRR 477
Cdd:COG1111  412 -FNV-LVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGRVVV---LIAKGTRDEAYYWS 476
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
 24-144 9.75e-09

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 56.20  E-value: 9.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  24 PTSLITNWTKEFAKWTP-GLRVKEFHG--TSKGERTRNLEKVQRRGgVVITTYTML---INNW---------QQLSSYQG 88
Cdd:cd18070   78 PSAILAQWLDEINRHVPsSLKVLTYQGvkKDGALASPAPEILAEYD-IVVTTYDVLrteLHYAeanrsnrrrRRQKRYEA 156

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 575523132  89 -----TEFTWDYMILDEAHKIKTSSTKTAKSASAIPSKHRVLLTGTPVQNNLKEMWALFDF 144
Cdd:cd18070  157 ppsplVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSF 217
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
 24-141 4.23e-08

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 53.45  E-value: 4.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  24 PTSLITNWTKE-FAKWTPGLRVKEFHGTSKGERTRNleKVQRRGGVVITTYTMLinnwQQLSSYQGT--EFTWDYMILDE 100
Cdd:cd18011   55 PASLVEQWQDElQDKFGLPFLILDRETAAQLRRLIG--NPFEEFPIVIVSLDLL----KRSEERRGLllSEEWDLVVVDE 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 575523132 101 AHKI-------KTSSTKTAKSASAIpSKHRVLLTGTPVQNNLKEMWAL 141
Cdd:cd18011  129 AHKLrnsgggkETKRYKLGRLLAKR-ARHVLLLTATPHNGKEEDFRAL 175
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
 31-167 7.12e-08

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 53.12  E-value: 7.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  31 WTKEFAKWT--PGLRVKEFHGTSKgERTRNLEKVQrrggvviTTYTMLINNWQQLSSYQGTEFTWDYMILDEAHKIKTSS 108
Cdd:cd18013   61 WPDEVEKWNhlRNLTVSVAVGTER-QRSKAANTPA-------DLYVINRENLKWLVNKSGDPWPFDMVVIDELSSFKSPR 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 575523132 109 TKTAKSASAI-PSKHR-VLLTGTPVQNNLKEMWALFDFACQGTLLG-TAKTFKAEYENPITR 167
Cdd:cd18013  133 SKRFKALRKVrPVIKRlIGLTGTPSPNGLMDLWAQIALLDQGERLGrSITAYRERWFDPDKR 194
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
347-482 2.53e-07

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 53.10  E-value: 2.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 347 ALLERLREE---GHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTiTQIAERERRITEFQTDKRysVFLLTTQVGGVGI 423
Cdd:COG1061  293 KILRELLREhpdDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGD-TPKKEREEILEAFRDGEL--RILVTVDVLNEGV 369

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 575523132 424 TLTAADRVVIYDPSWNPATDAQAVDRAYRIGQT-ENVVIYRLITCGT-VEEKIYRRQVFKD 482
Cdd:COG1061  370 DVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGkEDALVYDFVGNDVpVLEELAKDLRDLA 430
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
25-131 5.82e-06

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 48.87  E-value: 5.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  25 TSLITNWTKEFAKWTPGlrvKEFHGTSKgertrnlekvQRRGGVVITTYTMLINNwqqlSSYQGTEFTWDYMILDEAHKI 104
Cdd:COG1061  137 RELLEQWAEELRRFLGD---PLAGGGKK----------DSDAPITVATYQSLARR----AHLDELGDRFGLVIIDEAHHA 199

                         90       100
                 ....*....|....*....|....*..
gi 575523132 105 ktSSTKTAKSASAIPSKHRVLLTGTPV 131
Cdd:COG1061  200 --GAPSYRRILEAFPAAYRLGLTATPF 224
HDA2-3 pfam11496
Class II histone deacetylase complex subunits 2 and 3; This family of class II histone ...
 251-471 1.19e-05

Class II histone deacetylase complex subunits 2 and 3; This family of class II histone deacetylase complex subunits HDA2 and HDA3 is found in fungi, The member from S. pombe is referred to as Ccq1 in Swiss:Q10432. These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C-terminus.


Pssm-ID: 402894  Cd Length: 281  Bit Score: 46.94  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  251 TYLSSAQEDIYRQFISL---DHIKELLMTSRSPLAELTILKKLC--------DHPRLLSAAAIAKlgldentaesqQSDD 319
Cdd:pfam11496  10 TPMTSYQKELTEQIVSLhysDILKYCETSDSKEDISLIKSMTLClenlslvaTHPYLLVDHYMPK-----------SLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  320 TETDAHsianvsddtLISESGKLVFLFALL----ERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTITQIAE 395
Cdd:pfam11496  79 KDEPEK---------LAYTSGKFLVLNDLVnlliERDRKEPINVAIVARSGKTLDLVEALLLGKGLSYKRYSGEMLYGEN 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  396 RERRITEFQTDKRYSVFLLTTqvggvGITLT---------AADRVVIYDPSWNPATDAQAVDRAYRIGQTENVVIYRLIT 466
Cdd:pfam11496 150 KKVSDSGNKKIHSTTCHLLSS-----TGQLTnddsllenyKFDLIIAFDSSVDTSSPSVEHLRTQNRRKGNLAPIIRLVV 224


                  ....*
gi 575523132  467 CGTVE 471
Cdd:pfam11496 225 INSIE 229
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 25-130 1.83e-05

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 44.60  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  25 TSLITNWTKEFAKWtpglrvkeFHGTSKGERTRNLEKVQRRGGVVITTYTMLINNwQQLSSYQGTEFtwDYMILDEAHKI 104
Cdd:cd17926   54 DALLDQWKERFEDF--------LGDSSIGLIGGGKKKDFDDANVVVATYQSLSNL-AEEEKDLFDQF--GLLIVDEAHHL 122

                         90       100       110
                 ....*....|....*....|....*....|
gi 575523132 105 ktsstkTAKSASAIPSKH----RVLLTGTP 130
Cdd:cd17926  123 ------PAKTFSEILKELnakyRLGLTATP 146
DEXHc_XPB cd18029
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ...
 31-131 1.33e-04

DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350787 [Multi-domain]  Cd Length: 169  Bit Score: 42.67  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132  31 WTKEFAKWT--PGLRVKEFHGTSKgERTRNlekvqrrGGVVITTYTMLIN----NWQ-QLSSYQGTEFTWDYMILDEAHK 103
Cdd:cd18029   67 WRRQFLDWTtiDDEQIGRFTSDKK-EIFPE-------AGVTVSTYSMLANtrkrSPEsEKFMEFITEREWGLIILDEVHV 138

                         90       100
                 ....*....|....*....|....*...
gi 575523132 104 IKTSSTKtaKSASAIPSKHRVLLTGTPV 131
Cdd:cd18029  139 VPAPMFR--RVLTLQKAHCKLGLTATLV 164
PTZ00110 PTZ00110
helicase; Provisional
 335-456 2.62e-03

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 40.14  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 335 LISESGKLVFLFALLERLREEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTITQiAERERRITEFQTDKrySVFLL 414
Cdd:PTZ00110 356 VVEEHEKRGKLKMLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQ-EERTWVLNEFKTGK--SPIMI 432

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 575523132 415 TTQVGGVGITLTAADRVVIYD-PSwnpatdaQAVDRAYRIGQT 456
Cdd:PTZ00110 433 ATDVASRGLDVKDVKYVINFDfPN-------QIEDYVHRIGRT 468
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
346-456 6.81e-03

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 38.97  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575523132 346 FALLERL--REEGHRTLVFAHYRKVLDIIERILGHRGFKVMRLDGTITQiAERERRITEFQtDKRYSVfLLTTQVGGVGI 423
Cdd:COG0513  229 LELLRRLlrDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQ-GQRERALDAFR-NGKIRV-LVATDVAARGI 305

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 575523132 424 TLTAADRVVIYDPSWNPATdaqavdraY--RIGQT 456
Cdd:COG0513  306 DIDDVSHVINYDLPEDPED--------YvhRIGRT 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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