|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00927 |
PRK00927 |
tryptophanyl-tRNA synthetase; Reviewed |
11-351 |
0e+00 |
|
tryptophanyl-tRNA synthetase; Reviewed
Pssm-ID: 234866 [Multi-domain] Cd Length: 333 Bit Score: 600.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 11 KPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVRQDPEALRKSTLDVLALYLACGIDPNKSTIFIQ 90
Cdd:PRK00927 1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYECFFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFVQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 91 SHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARYEENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRDIAN 170
Cdd:PRK00927 81 SHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 171 RFNVLYGkkdaegnviePVFAVPEVFIAKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDGDEPPV 250
Cdd:PRK00927 161 RFNNLYG----------EVFPVPEPLIPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSERLRE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 251 VRYDVQNKAGVSNLLDILSAITGKTIAELEAEFE--GKMYGHLKTEVADKVSELLTNLQERYHHYRQDEALLEKIYREGA 328
Cdd:PRK00927 231 IRYDLPNKPEVSNLLTIYSALSGESIEELEAEYEagGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGA 310
|
330 340
....*....|....*....|...
gi 575446676 329 DKARARARATLDKVYELVGFVRY 351
Cdd:PRK00927 311 EKARAVASKTLKEVREAMGLLRK 333
|
|
| TrpS |
COG0180 |
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ... |
9-351 |
0e+00 |
|
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439950 [Multi-domain] Cd Length: 330 Bit Score: 550.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 9 MTKPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVRQDPEALRKSTLDVLALYLACGIDPNKSTIF 88
Cdd:COG0180 1 MSKKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 89 IQSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARY-EENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRD 167
Cdd:COG0180 81 VQSDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNgKENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 168 IANRFNVLYGkkdaegnviePVFAVPEVFIAKSGARVMSlLEPTKKMSKSDdnrNNVIGLLEDPKAVAKKIKRAMTDGDE 247
Cdd:COG0180 161 IARRFNHRYG----------EVFPEPEALIPEEGARIPG-LDGRKKMSKSY---GNTINLLDDPKEIRKKIKSAVTDSER 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 248 ppvVRYDVQNKAGVSNLLDILSAITGK-TIAELEAEFE--GKMYGHLKTEVADKVSELLTNLQERYHHYRQDEALLEKIY 324
Cdd:COG0180 227 ---LRYDDPGKPEVCNLFTIYSAFSGKeEVEELEAEYRagGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEIL 303
|
330 340
....*....|....*....|....*..
gi 575446676 325 REGADKARARARATLDKVYELVGFVRY 351
Cdd:COG0180 304 AEGAEKARAIAAKTLAEVREAMGLLYF 330
|
|
| TrpRS_core |
cd00806 |
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ... |
13-302 |
4.08e-141 |
|
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding
Pssm-ID: 173903 [Multi-domain] Cd Length: 280 Bit Score: 401.19 E-value: 4.08e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 13 IVFSGVQPSGELTIGNYLGALRNWVKMQD-DYDCVYCIVDQHAITVRQ-DPEALRKSTLDVLALYLACGIDPNKSTIFIQ 90
Cdd:cd00806 1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEaGYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 91 SHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSArYEENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRDIAN 170
Cdd:cd00806 81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSA-QGESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 171 RFNVLYGkkdaegnviePVFAVPEVFIAKsGARVMSLLEPTKKMSKSDDnrNNVIGLLEDPKAVAKKIKRAMTDGDepPV 250
Cdd:cd00806 160 RFNKLYG----------EIFPKPAALLSK-GAFLPGLQGPSKKMSKSDP--NNAIFLTDSPKEIKKKIMKAATDGG--RT 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 575446676 251 VRYDVQNKAGVSNLLDILSAITGKTIAELEA----EFEGKMYGHLKTEVADKVSEL 302
Cdd:cd00806 225 EHRRDGGGPGVSNLVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQEF 280
|
|
| trpS |
TIGR00233 |
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ... |
11-348 |
1.64e-138 |
|
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 272975 [Multi-domain] Cd Length: 327 Bit Score: 396.32 E-value: 1.64e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 11 KPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVRQ-DPEALRKSTLDVLALYLACGIDPNKSTIFI 89
Cdd:TIGR00233 2 KFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQtDPDALRKAREELAADYLAVGLDPEKTFIFL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 90 QSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSarYEENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRDIA 169
Cdd:TIGR00233 82 QSDYPEHYELAWLLSCQVTFGELKRMTQFKDKS--QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 170 NRFNVLYGKKdaegnviepvFAVPEVFIAKSGARVMSLlePTKKMSKSDDnrNNVIGLLEDPKAVAKKIKRAMTDGDEPp 249
Cdd:TIGR00233 160 ERFNKKFKNF----------FPKPESLISKFFPRLMGL--SGKKMSKSDP--NSAIFLTDTPKQIKKKIRKAATDGGRV- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 250 vVRYDVQNKAGVSNLLDILSAITGKTI------AELEAEFEGK-MYGHLKTEVADKVSELLTNLQERYHHYrqDEALLEK 322
Cdd:TIGR00233 225 -TLFEHREKPGVPNLLVIYQYLSFFLIdddklkEIYEAYKSGKlGYGECKKALIEVLQEFLKEIQERRAEI--AEEILDK 301
|
330 340
....*....|....*....|....*.
gi 575446676 323 IYREGADKARARARATLDKVYELVGF 348
Cdd:TIGR00233 302 ILEPGAKKARETANKTLADVYKAMGL 327
|
|
| tRNA-synt_1b |
pfam00579 |
tRNA synthetases class I (W and Y); |
11-304 |
1.66e-92 |
|
tRNA synthetases class I (W and Y);
Pssm-ID: 395461 [Multi-domain] Cd Length: 292 Bit Score: 278.01 E-value: 1.66e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 11 KPIVFSGVQPSGELTIGnYLGALRNWVKMQDD-YDCVYCIVDQHAITVRQD---PEALRKSTLDVLAL---YLACGIDPN 83
Cdd:pfam00579 5 PLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAgHEVFFLIGDLHAIIGDPSkspERKLLSRETVLENAikaQLACGLDPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 84 KSTIFIQSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARYEEN--VNVGLFTYPVLMAADILLYQANQVPVGDDQKQH 161
Cdd:pfam00579 84 KAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGpgISLGEFTYPLLQAYDILLLKADLQPGGSDQWGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 162 LEITRDIANRFNvlygkkdaegnviEPVFAVPEVFIAKsgarVMSLLEPTKKMSKSDDNRnnVIGLLEDPKAVAKKIKRA 241
Cdd:pfam00579 164 IELGRDLARRFN-------------KKIFKKPVGLTNP----LLTGLDGGKKMSKSAGNS--AIFLDDDPESVYKKIQKA 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 242 MTDGDEppVVRYDVQNKAGVSN-LLDILSAITGKTI----AELEAEFEGKM--YGHLKTEVADKVSELLT 304
Cdd:pfam00579 225 YTDPDR--EVRKDLKLFTFLSNeEIEILEAELGKSPyreaEELLAREVTGLvhGGDLKKAAAEAVNKLLQ 292
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK00927 |
PRK00927 |
tryptophanyl-tRNA synthetase; Reviewed |
11-351 |
0e+00 |
|
tryptophanyl-tRNA synthetase; Reviewed
Pssm-ID: 234866 [Multi-domain] Cd Length: 333 Bit Score: 600.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 11 KPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVRQDPEALRKSTLDVLALYLACGIDPNKSTIFIQ 90
Cdd:PRK00927 1 KKRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYECFFCIADLHALTVPQDPEELRENTRELAADYLACGIDPEKSTIFVQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 91 SHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARYEENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRDIAN 170
Cdd:PRK00927 81 SHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKENVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDIAR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 171 RFNVLYGkkdaegnviePVFAVPEVFIAKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDGDEPPV 250
Cdd:PRK00927 161 RFNNLYG----------EVFPVPEPLIPKVGARVMGLDGPTKKMSKSDPNDNNTINLLDDPKTIAKKIKKAVTDSERLRE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 251 VRYDVQNKAGVSNLLDILSAITGKTIAELEAEFE--GKMYGHLKTEVADKVSELLTNLQERYHHYRQDEALLEKIYREGA 328
Cdd:PRK00927 231 IRYDLPNKPEVSNLLTIYSALSGESIEELEAEYEagGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGA 310
|
330 340
....*....|....*....|...
gi 575446676 329 DKARARARATLDKVYELVGFVRY 351
Cdd:PRK00927 311 EKARAVASKTLKEVREAMGLLRK 333
|
|
| TrpS |
COG0180 |
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ... |
9-351 |
0e+00 |
|
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439950 [Multi-domain] Cd Length: 330 Bit Score: 550.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 9 MTKPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVRQDPEALRKSTLDVLALYLACGIDPNKSTIF 88
Cdd:COG0180 1 MSKKRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTPQDPEELRENTREVAADYLAAGLDPEKSTIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 89 IQSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARY-EENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRD 167
Cdd:COG0180 81 VQSDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNgKENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 168 IANRFNVLYGkkdaegnviePVFAVPEVFIAKSGARVMSlLEPTKKMSKSDdnrNNVIGLLEDPKAVAKKIKRAMTDGDE 247
Cdd:COG0180 161 IARRFNHRYG----------EVFPEPEALIPEEGARIPG-LDGRKKMSKSY---GNTINLLDDPKEIRKKIKSAVTDSER 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 248 ppvVRYDVQNKAGVSNLLDILSAITGK-TIAELEAEFE--GKMYGHLKTEVADKVSELLTNLQERYHHYRQDEALLEKIY 324
Cdd:COG0180 227 ---LRYDDPGKPEVCNLFTIYSAFSGKeEVEELEAEYRagGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEIL 303
|
330 340
....*....|....*....|....*..
gi 575446676 325 REGADKARARARATLDKVYELVGFVRY 351
Cdd:COG0180 304 AEGAEKARAIAAKTLAEVREAMGLLYF 330
|
|
| PLN02886 |
PLN02886 |
aminoacyl-tRNA ligase |
9-351 |
8.39e-145 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215478 [Multi-domain] Cd Length: 389 Bit Score: 414.60 E-value: 8.39e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 9 MTKPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVRQDPEALRKSTLDVLALYLACGIDPNKSTIF 88
Cdd:PLN02886 44 ARKKRVVSGVQPTGSIHLGNYLGAIKNWVALQETYDTFFCVVDLHAITLPHDPRELGKATRSTAAIYLACGIDPSKASVF 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 89 IQSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARY-EENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRD 167
Cdd:PLN02886 124 VQSHVPAHAELMWLLSCSTPIGWLNKMIQFKEKSRKAgDENVGVGLLTYPVLMASDILLYQADLVPVGEDQKQHLELTRD 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 168 IANRFNVLYG--KKDAEGNVIEPVFAVPEVFIAKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKAVAKKIKRAMTDG 245
Cdd:PLN02886 204 IAERVNNLYGgrKWKKLGGRGGSVFKVPEALIPPAGARVMSLTDGTSKMSKSAPSDQSRINLLDPPDVIANKIKRCKTDS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 246 dePPVVRYDVQNKAGVSNLLDILSAITGKTIAELEAEFEGKMYGHLKTEVADKVSELLTNLQERYHHYRQDEALLEKIYR 325
Cdd:PLN02886 284 --FPGLEFDNPERPECNNLLSIYQLVTGKTKEEVLAECGDMRWGDFKPLLTDALIEHLSPIQVRYEEIMSDPSYLDSVLK 361
|
330 340
....*....|....*....|....*.
gi 575446676 326 EGADKARARARATLDKVYELVGFVRY 351
Cdd:PLN02886 362 EGADAAAEIADRTLANVYQAMGFVQR 387
|
|
| TrpRS_core |
cd00806 |
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ... |
13-302 |
4.08e-141 |
|
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding
Pssm-ID: 173903 [Multi-domain] Cd Length: 280 Bit Score: 401.19 E-value: 4.08e-141
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 13 IVFSGVQPSGELTIGNYLGALRNWVKMQD-DYDCVYCIVDQHAITVRQ-DPEALRKSTLDVLALYLACGIDPNKSTIFIQ 90
Cdd:cd00806 1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEaGYELFFFIADLHALTVKQlDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 91 SHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSArYEENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRDIAN 170
Cdd:cd00806 81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSA-QGESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDIAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 171 RFNVLYGkkdaegnviePVFAVPEVFIAKsGARVMSLLEPTKKMSKSDDnrNNVIGLLEDPKAVAKKIKRAMTDGDepPV 250
Cdd:cd00806 160 RFNKLYG----------EIFPKPAALLSK-GAFLPGLQGPSKKMSKSDP--NNAIFLTDSPKEIKKKIMKAATDGG--RT 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 575446676 251 VRYDVQNKAGVSNLLDILSAITGKTIAELEA----EFEGKMYGHLKTEVADKVSEL 302
Cdd:cd00806 225 EHRRDGGGPGVSNLVEIYSAFFNDDDEELEEideyRSGGLGYGECKKLLAEAIQEF 280
|
|
| trpS |
TIGR00233 |
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ... |
11-348 |
1.64e-138 |
|
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 272975 [Multi-domain] Cd Length: 327 Bit Score: 396.32 E-value: 1.64e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 11 KPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVRQ-DPEALRKSTLDVLALYLACGIDPNKSTIFI 89
Cdd:TIGR00233 2 KFRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQtDPDALRKAREELAADYLAVGLDPEKTFIFL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 90 QSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSarYEENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRDIA 169
Cdd:TIGR00233 82 QSDYPEHYELAWLLSCQVTFGELKRMTQFKDKS--QAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 170 NRFNVLYGKKdaegnviepvFAVPEVFIAKSGARVMSLlePTKKMSKSDDnrNNVIGLLEDPKAVAKKIKRAMTDGDEPp 249
Cdd:TIGR00233 160 ERFNKKFKNF----------FPKPESLISKFFPRLMGL--SGKKMSKSDP--NSAIFLTDTPKQIKKKIRKAATDGGRV- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 250 vVRYDVQNKAGVSNLLDILSAITGKTI------AELEAEFEGK-MYGHLKTEVADKVSELLTNLQERYHHYrqDEALLEK 322
Cdd:TIGR00233 225 -TLFEHREKPGVPNLLVIYQYLSFFLIdddklkEIYEAYKSGKlGYGECKKALIEVLQEFLKEIQERRAEI--AEEILDK 301
|
330 340
....*....|....*....|....*.
gi 575446676 323 IYREGADKARARARATLDKVYELVGF 348
Cdd:TIGR00233 302 ILEPGAKKARETANKTLADVYKAMGL 327
|
|
| PRK12282 |
PRK12282 |
tryptophanyl-tRNA synthetase II; Reviewed |
10-347 |
5.48e-97 |
|
tryptophanyl-tRNA synthetase II; Reviewed
Pssm-ID: 183400 [Multi-domain] Cd Length: 333 Bit Score: 290.99 E-value: 5.48e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 10 TKPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAIT-VRQDPEALRKSTLDVLALYLACGIDPNKSTIF 88
Cdd:PRK12282 1 TKPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVLIADQQALTdNAKNPEKIRRNILEVALDYLAVGIDPAKSTIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 89 IQSHVPEHAQLAWV-LNCYTyFGEMSRMTQFKDKSAR--YEENVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEIT 165
Cdd:PRK12282 81 IQSQIPELAELTMYyMNLVT-VARLERNPTVKTEIAQkgFGRSIPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 166 RDIANRFNVLYGkkdaegnviEPVFAVPEVFIAKSGaRVMSlLEPTKKMSKSDdnrNNVIGLLEDPKAVAKKIKRAMTDg 245
Cdd:PRK12282 160 REIVRRFNSLYG---------TDVLVEPEALLPEAG-RLPG-LDGKAKMSKSL---GNAIYLSDDADTIKKKVMSMYTD- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 246 dePPVVRYDVQNKAGVSNLLDILSAI--TGKTIAELEAEFEGKMYG--HLKTEVADKVSELLTNLQERYHHYRQDEALLE 321
Cdd:PRK12282 225 --PNHIRVEDPGKVEGNVVFTYLDAFdpDKAEVAELKAHYQRGGLGdvKCKRYLEEVLQELLAPIRERRAEFAKDPGYVL 302
|
330 340
....*....|....*....|....*.
gi 575446676 322 KIYREGADKARARARATLDKVYELVG 347
Cdd:PRK12282 303 EILKAGSEKAREVAAQTLSEVKDAMG 328
|
|
| tRNA-synt_1b |
pfam00579 |
tRNA synthetases class I (W and Y); |
11-304 |
1.66e-92 |
|
tRNA synthetases class I (W and Y);
Pssm-ID: 395461 [Multi-domain] Cd Length: 292 Bit Score: 278.01 E-value: 1.66e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 11 KPIVFSGVQPSGELTIGnYLGALRNWVKMQDD-YDCVYCIVDQHAITVRQD---PEALRKSTLDVLAL---YLACGIDPN 83
Cdd:pfam00579 5 PLRVYSGIDPTGPLHLG-YLVPLMKLRQFQQAgHEVFFLIGDLHAIIGDPSkspERKLLSRETVLENAikaQLACGLDPE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 84 KSTIFIQSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARYEEN--VNVGLFTYPVLMAADILLYQANQVPVGDDQKQH 161
Cdd:pfam00579 84 KAEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGpgISLGEFTYPLLQAYDILLLKADLQPGGSDQWGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 162 LEITRDIANRFNvlygkkdaegnviEPVFAVPEVFIAKsgarVMSLLEPTKKMSKSDDNRnnVIGLLEDPKAVAKKIKRA 241
Cdd:pfam00579 164 IELGRDLARRFN-------------KKIFKKPVGLTNP----LLTGLDGGKKMSKSAGNS--AIFLDDDPESVYKKIQKA 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 242 MTDGDEppVVRYDVQNKAGVSN-LLDILSAITGKTI----AELEAEFEGKM--YGHLKTEVADKVSELLT 304
Cdd:pfam00579 225 YTDPDR--EVRKDLKLFTFLSNeEIEILEAELGKSPyreaEELLAREVTGLvhGGDLKKAAAEAVNKLLQ 292
|
|
| PRK12556 |
PRK12556 |
tryptophanyl-tRNA synthetase; Provisional |
9-348 |
9.43e-80 |
|
tryptophanyl-tRNA synthetase; Provisional
Pssm-ID: 183592 [Multi-domain] Cd Length: 332 Bit Score: 246.94 E-value: 9.43e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 9 MTKPIVFSGVQPSGELTIGNYLGALRNWVKMQDDYDC--VYCIVDQHAITVRQDPEALRKSTLDVLALYLACGIDPNKST 86
Cdd:PRK12556 1 MSEKIMLTGIKPTGYPHLGNYIGAIKPALQMAKNYEGkaLYFIADYHALNAVHDPEQFRSYTREVAATWLSLGLDPEDVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 87 IFIQSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARYEE-------NVNVGLFTYPVLMAADILLYQANQVPVGDDQK 159
Cdd:PRK12556 81 FYRQSDVPEIFELAWILSCLTPKGLMNRAHAYKAKVDQNKEagldldaGVNMGLYTYPILMAADILLFQATHVPVGKDQI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 160 QHLEITRDIANRFNVLYGKkdaegnviepVFAVPEVFIAKSGArVMSLLEpTKKMSKSDDnrnNVIGLLEDPKAVAKKIK 239
Cdd:PRK12556 161 QHIEIARDIATYFNHTFGD----------TFTLPEYVIQEEGA-ILPGLD-GRKMSKSYG---NVIPLFAEQEKLRKLIF 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 240 RAMTDgDEPPVVRYDVQNkagvSNLLDILSAI-TGKTIAELEAEFEGKM-YGHLKTEVADKVSELLTNLQERYHHYRQDE 317
Cdd:PRK12556 226 KIKTD-SSLPNEPKDPET----SALFTIYKEFaTEEEVQSMREKYETGIgWGDVKKELFRVVDRELAGPREKYAMYMNEP 300
|
330 340 350
....*....|....*....|....*....|.
gi 575446676 318 ALLEKIYREGADKARARARATLDKVYELVGF 348
Cdd:PRK12556 301 SLLDEALEKGAERAREIAKPNLAEIKKAIGF 331
|
|
| PRK12283 |
PRK12283 |
tryptophanyl-tRNA synthetase; Reviewed |
14-347 |
1.62e-70 |
|
tryptophanyl-tRNA synthetase; Reviewed
Pssm-ID: 183401 [Multi-domain] Cd Length: 398 Bit Score: 225.22 E-value: 1.62e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 14 VFSGVQPSGELTIGNYLGALRNWVKMQDDYDCVYCIVDQHAITVR-QDPEALRKSTLDVLALYLACGIDPNKSTIFIQSH 92
Cdd:PRK12283 5 VLSGMRPTGRLHLGHYHGVLKNWVKLQHEYECFFFVADWHALTTHyETPEVIEKNVWDMVIDWLAAGVDPAQATLFIQSK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 93 VPEHAQLAWVLNCYTYFGEMSRMTQFKDKSARYEEN--VNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEITRDIAN 170
Cdd:PRK12283 85 VPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKdlSTYGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMTREIAR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 171 RFNVLYGK-KDAEGNVIEPV--------------------------FAVPEVFIAKS----------------GARVMSL 207
Cdd:PRK12283 165 RFNHLYGRePGFEEKAEAAIkklgkkraklyhelrnayqeegddeaLEQARALLQEQqnlsmgdrerlfgyleGAGKIIL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 208 LEP----TK----------KMSKSddnRNNVIGLLEDPKAVAKKIKRAMTD---------GDeP---PV-----VRYDVQ 256
Cdd:PRK12283 245 PEPqallTEaskmpgldgqKMSKS---YGNTIGLREDPESVTKKIRTMPTDparvrrtdpGD-PekcPVwqlhqVYSDEE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 257 NKAGVSNlldilsAITGKTIAELEAefegkmyghlKTEVADKVSELLTNLQERYHHYRQDEALLEKIYREGADKARARAR 336
Cdd:PRK12283 321 TKEWVQK------GCRSAGIGCLEC----------KQPVIDAILREQQPMRERAQKYEDDPSLVRAIVADGCEKARKVAR 384
|
410
....*....|.
gi 575446676 337 ATLDKVYELVG 347
Cdd:PRK12283 385 ETMRDVREAMG 395
|
|
| PRK12284 |
PRK12284 |
tryptophanyl-tRNA synthetase; Reviewed |
14-347 |
4.85e-63 |
|
tryptophanyl-tRNA synthetase; Reviewed
Pssm-ID: 237036 [Multi-domain] Cd Length: 431 Bit Score: 206.78 E-value: 4.85e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 14 VFSGVQPSGELTIGNYLGALRNWVKM--QDDYDCVYCIVDQHAITVRQDPEALRKSTLDVLALYLACGIDPNKSTIFIQS 91
Cdd:PRK12284 5 VLTGITTTGTPHLGNYAGAIRPAIAAsrQPGVESFYFLADYHALIKCDDPARIQRSTLEIAATWLAAGLDPERVTFYRQS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 92 HVPEHAQLAWVLNCYTYFGEMSRMTQFK---DK-SARYEE---NVNVGLFTYPVLMAADILLYQANQVPVGDDQKQHLEI 164
Cdd:PRK12284 85 DIPEIPELTWLLTCVAGKGLLNRAHAYKaavDKnVAAGEDpdaGVTAGLFMYPVLMAADILMFNAHKVPVGRDQIQHIEM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 165 TRDIANRFNVLYGKKdaegnviepVFAVPEVFIAKSGARVMSLlePTKKMSKSDDnrnNVIGLLEDPKAVAKKIKRAMTD 244
Cdd:PRK12284 165 ARDIAQRFNHLYGGE---------FFVLPEAVIEESVATLPGL--DGRKMSKSYD---NTIPLFAPREELKKAIFSIVTD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 245 GDEPPVVRyDVQNkagvSNLLDILSAI-TGKTIAELEAEFEGKM-YGHLKTEVADKVSELLTNLQERYHHYRQDEALLEK 322
Cdd:PRK12284 231 SRAPGEPK-DTEG----SALFQLYQAFaTPEETAAFRQALADGIgWGDAKQRLFERIDRELAPMRERYEALIARPADIED 305
|
330 340
....*....|....*....|....*
gi 575446676 323 IYREGADKARARARATLDKVYELVG 347
Cdd:PRK12284 306 ILLAGAAKARRIATPFLAELREAVG 330
|
|
| Tyr_Trp_RS_core |
cd00395 |
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ... |
14-302 |
1.85e-55 |
|
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173893 [Multi-domain] Cd Length: 273 Bit Score: 182.50 E-value: 1.85e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 14 VFSGVQPSGE-LTIGNYLGaLRNWVKMQD-DYDCVYCIVDQHAITV----------RQDPEALRKSTLDVLALYLACGID 81
Cdd:cd00395 2 LYCGIDPTADsLHIGHLIG-LLTFRRFQHaGHRPIFLIGGQTGIIGdpsgkksertLNDPEEVRQNIRRIAAQYLAVGIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 82 --PNKSTIFIQSHVP---EHAQLAWVLNCYTYFGEMSRMTQFKDKSaryEENVNVGLFTYPVLMAADILLYQANQ----V 152
Cdd:cd00395 81 edPTQATLFNNSDWPgplAHIQFLRDLGKHVYVNYMERKTSFQSRS---EEGISATEFTYPPLQAADFLLLNTTEgcdiQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 153 PVGDDQKQHLEITRDIANRFNvlyGKKDAEGNVIepvfavpevfiaksgARVMSLLEPtkKMSKSDDNRNNVIGLLEDPK 232
Cdd:cd00395 158 PGGSDQWGNITLGRELARRFN---GFTIAEGLTI---------------PLVTKLDGP--KFGKSESGPKWLDTEKTSPY 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 575446676 233 AVAKKIKRAMtdgdeppvvrydvqnkagVSNLLDILSAITGKTIAELEA----EFEGKMYGHLKTEVADKVSEL 302
Cdd:cd00395 218 EFYQFWINAV------------------DSDVINILKYFTFLSKEEIERleqeQYEAPGYRVAQKTLAEEVTKT 273
|
|
| PRK12285 |
PRK12285 |
tryptophanyl-tRNA synthetase; Reviewed |
14-310 |
1.29e-24 |
|
tryptophanyl-tRNA synthetase; Reviewed
Pssm-ID: 237037 [Multi-domain] Cd Length: 368 Bit Score: 102.64 E-value: 1.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 14 VFSGVQPSGELTIGNYL--GALRNWVKMQDDydcVY-CIVDQHAITVR-QDPEALRKSTLDVLALYLACGIDPNKSTIFI 89
Cdd:PRK12285 69 VYTGFMPSGPMHIGHKMvfDELKWHQEFGAN---VYiPIADDEAYAARgLSWEETREWAYEYILDLIALGFDPDKTEIYF 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 90 QSHVPEHAQLAWVLNCYTYFGEMSRMTQFKDKSaryeenvNVGLFTYPVLMAADILLYQANQ------VPVGDDQKQHLE 163
Cdd:PRK12285 146 QSENIKVYDLAFELAKKVNFSELKAIYGFTGET-------NIGHIFYPATQAADILHPQLEEgpkptlVPVGIDQDPHIR 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 164 ITRDIANRFNVLYGkkdaegnviepvfavpevFIAKSG--ARVMSLLEPTkKMSKSDDnrNNVIGLLEDPKAVAKKIKRA 241
Cdd:PRK12285 219 LTRDIAERLHGGYG------------------FIKPSStyHKFMPGLTGG-KMSSSKP--ESAIYLTDDPETVKKKIMKA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 242 MTDG--------------DEPPVvrYDvqnkagvsnLLDILSAITGKTIAELEAEF-EGK-MYGHLKTEVADKVSELLTN 305
Cdd:PRK12285 278 LTGGratleeqrklggepDECVV--YE---------LLLYHLEEDDKELKEIYEECrSGElLCGECKKEAAEKIAEFLKE 346
|
....*
gi 575446676 306 LQERY 310
Cdd:PRK12285 347 HQEKR 351
|
|
| class_I_aaRS_core |
cd00802 |
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ... |
13-218 |
4.50e-09 |
|
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173901 [Multi-domain] Cd Length: 143 Bit Score: 54.41 E-value: 4.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 13 IVFSGVQPSGELTIGNYLGALRNWVKMQD------DYDCVYCIVDQHAITVRQDPEALRkstldvlalylacgidpnkst 86
Cdd:cd00802 1 TTFSGITPNGYLHIGHLRTIVTFDFLAQAyrklgyKVRCIALIDDAGGLIGDPANKKGE--------------------- 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 87 ifiqshVPEHAQLAWvlncytyfgemsrmtqfkdkSARYEEnvnvgLFTYPVLMAADILLYQANQ---VPVGDDQKQHLE 163
Cdd:cd00802 60 ------NAKAFVERW--------------------IERIKE-----DVEYMFLQAADFLLLYETEcdiHLGGSDQLGHIE 108
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 575446676 164 ITRDIANRFnvlYGKKDAEGNVIEpvfavpevfiaksgaRVMSllEPTKKMSKSD 218
Cdd:cd00802 109 LGLELLKKA---GGPARPFGLTFG---------------RVMG--ADGTKMSKSK 143
|
|
| TyrRS_core |
cd00805 |
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ... |
112-302 |
4.50e-09 |
|
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173902 [Multi-domain] Cd Length: 269 Bit Score: 56.46 E-value: 4.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 112 MSRMTQFKDKSARYEENVNVGL--FTYPVLMAADIL-LYQANQVPvGDDQKQHLEITRDIANRfnvlYGKKdaegnvieP 188
Cdd:cd00805 113 VNRMLRRDAVKVRLEEEEGISFseFIYPLLQAYDFVyLDVDLQLG-GSDQRGNITLGRDLIRK----LGYK--------K 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 189 VFAVpevfiaksgarVMSLLEPT--KKMSKSDDNrNNVIGLLEDPKAVAKKIKRAmtdgdeppvvrYDvqnkAGVSNLLD 266
Cdd:cd00805 180 VVGL-----------TTPLLTGLdgGKMSKSEGN-AIWDPVLDSPYDVYQKIRNA-----------FD----PDVLEFLK 232
|
170 180 190
....*....|....*....|....*....|....*..
gi 575446676 267 ILSAITGKTIAELEAEF-EGKMYGHLKTEVADKVSEL 302
Cdd:cd00805 233 LFTFLDYEEIEELEEEHaEGPLPRDAKKALAEELTKL 269
|
|
| PRK08560 |
PRK08560 |
tyrosyl-tRNA synthetase; Validated |
11-241 |
1.97e-05 |
|
tyrosyl-tRNA synthetase; Validated
Pssm-ID: 236286 [Multi-domain] Cd Length: 329 Bit Score: 46.01 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 11 KPIVFSGVQPSGELTIGNYLgalrnWV-KMQD----DYDCVYCIVDQHA-ITVRQDPEALRKSTLDVLALYLACGIDPNK 84
Cdd:PRK08560 30 EPKAYIGFEPSGKIHLGHLL-----TMnKLADlqkaGFKVTVLLADWHAyLNDKGDLEEIRKVAEYNKKVFEALGLDPDK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 85 STIF----IQSHvPEHAQLAWVLNCYTyfgEMSRMTQFKDKSARYEENVNVGLFTYPVLMAADIlLYQANQVPVG--DDQ 158
Cdd:PRK08560 105 TEFVlgseFQLD-KEYWLLVLKLAKNT---TLARARRSMTIMGRRMEEPDVSKLVYPLMQVADI-FYLDVDIAVGgmDQR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 159 KQHLeITRDIANRFNVlygKKdaegnviePVfAVPEVFIAksgarvmSLLEPTKKMSKSDDnrNNVIGLLEDPKAVAKKI 238
Cdd:PRK08560 180 KIHM-LAREVLPKLGY---KK--------PV-CIHTPLLT-------GLDGGGIKMSKSKP--GSAIFVHDSPEEIRRKI 237
|
...
gi 575446676 239 KRA 241
Cdd:PRK08560 238 KKA 240
|
|
| nt_trans |
cd02156 |
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ... |
14-81 |
2.06e-04 |
|
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.
Pssm-ID: 173912 [Multi-domain] Cd Length: 105 Bit Score: 40.21 E-value: 2.06e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 575446676 14 VFSGVQPsGELTIGNYLGALRNwvkMQDDYDCVYCIVDQHAITVRQDPEALRKSTLDVLALYLACGID 81
Cdd:cd02156 2 ARFPGEP-GYLHIGHAKLICRA---KGIADQCVVRIDDNPPVKVWQDPHELEERKESIEEDISVCGED 65
|
|
| PTZ00126 |
PTZ00126 |
tyrosyl-tRNA synthetase; Provisional |
136-323 |
3.21e-04 |
|
tyrosyl-tRNA synthetase; Provisional
Pssm-ID: 240282 [Multi-domain] Cd Length: 383 Bit Score: 42.37 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 136 YPVLMAADILLYQANQVPVGDDQKQHLEITRDIANRfnvlygKKDAEGNVIepvfavpevfiaKSGARVMSLLEPTKKMS 215
Cdd:PTZ00126 198 YPCMQCADIFYLKADICQLGMDQRKVNMLAREYCDK------KKIKKKPII------------LSHHMLPGLLEGQEKMS 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575446676 216 KSDDnrNNVIGLLEDPKAVAKKIKRA-----MTDGDepPVVRYDVQNKAGVSNLLDILSA------ITGKTIAELEAEF- 283
Cdd:PTZ00126 260 KSDP--NSAIFMEDSEEDVNRKIKKAycppgVIEGN--PILAYFKSIVFPAFNSFTVLRKeknggdVTYTTYEELEKDYl 335
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 575446676 284 EGKMY-GHLKTEVADKVSELltnLQERYHHYRQDE---ALLEKI 323
Cdd:PTZ00126 336 SGALHpGDLKPALAKYLNLM---LQPVRDHFQNNPeakSLLSEV 376
|
|
| |
