hypothetical protein PFUGPA_00130 [Plasmodium falciparum Palo Alto/Uganda]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RIFIN super family | cl14106 | Rifin; Plasmodium falciparum is the causative agent of deadly malaria disease. It encodes ... |
1-79 | 1.24e-22 | ||
Rifin; Plasmodium falciparum is the causative agent of deadly malaria disease. It encodes repetitive interspersed families of polypeptides (RIFINs), which are expressed on the surface of infected erythrocytes. All RIFIN sequences contain the PEXEL motif (a pentameric sequence RxLxE/Q/D, known as the Plasmodium export element) required for correct export and surface expression or host-targeting (HT) signal which plays a central role in the export of proteins into the host cell. It has been reported that PEXEL is preferably located 15-20 amino acids downstream of an N-terminal hydrophobic signal sequence. The RIFIN protein family can be divided into A and B types based on the presence or absence of a 25 amino acid motif located approximately 66 amino acids downstream of the PEXEL motif, with A- and B-types serving different roles in distinct parasite stages. The specific type B RIFIN variant (PF13_0006) is expressed on the surface of free merozoites, internally in developing gametocytes and on the surface of gametes at the point of emerging from activated, mature stage V gametocytes. While type A RIFIN are expressed on the infected erythrocyte surface, potentially contributing to the antigenic variation capacity of the parasite. The actual alignment was detected with superfamily member PTZ00370: Pssm-ID: 417466 Cd Length: 296 Bit Score: 87.78 E-value: 1.24e-22
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| Name | Accession | Description | Interval | E-value | ||
| PTZ00370 | PTZ00370 | STEVOR; Provisional |
1-79 | 1.24e-22 | ||
STEVOR; Provisional Pssm-ID: 240386 Cd Length: 296 Bit Score: 87.78 E-value: 1.24e-22
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| Stevor | pfam17410 | Subtelomeric Variable Open Reading frame; The parasite protein STEVOR (Subtelomeric Variable ... |
1-79 | 7.63e-22 | ||
Subtelomeric Variable Open Reading frame; The parasite protein STEVOR (Subtelomeric Variable Open Reading frame) is an erythrocyte-binding protein recognizing Glycophorin C on the red blood cell (RBC) surface. The cytoplasmic domain of STEVOR is shown to interact with ankyrin complex at the erythrocyte skeleton. It is phosphorylated by protein kinase A (PKA) at a specific serine residue (S324). The N-terminal semi-conserved region of Stevor that is present in this domain is shown to specifically bind to to a chymotrypsin-resistant RBC receptor. The expression of STEVOR in multiple parasite stages including merozoites suggests that STEVOR mediates multiple distinct functions in parasitic infectious cycle. Pssm-ID: 407484 Cd Length: 275 Bit Score: 85.52 E-value: 7.63e-22
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| STEVOR | TIGR01478 | variant surface antigen, stevor family; This model represents the stevor branch of the rifin ... |
1-74 | 9.31e-13 | ||
variant surface antigen, stevor family; This model represents the stevor branch of the rifin/stevor family (pfam02009) of predicted variant surface antigens as found in Plasmodium falciparum. This model is based on a set of stevor sequences kindly provided by Matt Berriman from the Sanger Center. This is a global model and assesses a penalty for incomplete sequence. Additional fragmentary sequences may be found with the fragment model and a cutoff of 8 bits. Pssm-ID: 130543 Cd Length: 295 Bit Score: 61.02 E-value: 9.31e-13
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| Name | Accession | Description | Interval | E-value | ||
| PTZ00370 | PTZ00370 | STEVOR; Provisional |
1-79 | 1.24e-22 | ||
STEVOR; Provisional Pssm-ID: 240386 Cd Length: 296 Bit Score: 87.78 E-value: 1.24e-22
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| Stevor | pfam17410 | Subtelomeric Variable Open Reading frame; The parasite protein STEVOR (Subtelomeric Variable ... |
1-79 | 7.63e-22 | ||
Subtelomeric Variable Open Reading frame; The parasite protein STEVOR (Subtelomeric Variable Open Reading frame) is an erythrocyte-binding protein recognizing Glycophorin C on the red blood cell (RBC) surface. The cytoplasmic domain of STEVOR is shown to interact with ankyrin complex at the erythrocyte skeleton. It is phosphorylated by protein kinase A (PKA) at a specific serine residue (S324). The N-terminal semi-conserved region of Stevor that is present in this domain is shown to specifically bind to to a chymotrypsin-resistant RBC receptor. The expression of STEVOR in multiple parasite stages including merozoites suggests that STEVOR mediates multiple distinct functions in parasitic infectious cycle. Pssm-ID: 407484 Cd Length: 275 Bit Score: 85.52 E-value: 7.63e-22
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| STEVOR | TIGR01478 | variant surface antigen, stevor family; This model represents the stevor branch of the rifin ... |
1-74 | 9.31e-13 | ||
variant surface antigen, stevor family; This model represents the stevor branch of the rifin/stevor family (pfam02009) of predicted variant surface antigens as found in Plasmodium falciparum. This model is based on a set of stevor sequences kindly provided by Matt Berriman from the Sanger Center. This is a global model and assesses a penalty for incomplete sequence. Additional fragmentary sequences may be found with the fragment model and a cutoff of 8 bits. Pssm-ID: 130543 Cd Length: 295 Bit Score: 61.02 E-value: 9.31e-13
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