Rifin; Plasmodium falciparum is the causative agent of deadly malaria disease. It encodes repetitive interspersed families of polypeptides (RIFINs), which are expressed on the surface of infected erythrocytes. All RIFIN sequences contain the PEXEL motif (a pentameric sequence RxLxE/Q/D, known as the Plasmodium export element) required for correct export and surface expression or host-targeting (HT) signal which plays a central role in the export of proteins into the host cell. It has been reported that PEXEL is preferably located 15-20 amino acids downstream of an N-terminal hydrophobic signal sequence. The RIFIN protein family can be divided into A and B types based on the presence or absence of a 25 amino acid motif located approximately 66 amino acids downstream of the PEXEL motif, with A- and B-types serving different roles in distinct parasite stages. The specific type B RIFIN variant (PF13_0006) is expressed on the surface of free merozoites, internally in developing gametocytes and on the surface of gametes at the point of emerging from activated, mature stage V gametocytes. While type A RIFIN are expressed on the infected erythrocyte surface, potentially contributing to the antigenic variation capacity of the parasite.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574977306    9 IPLKAQEIVTQGTKAADAKTAEVSSRIAADITTKQTTAINSTYASYEITIIASIVAIVVIVLIMVIIYLILRYRRKTKMK 88
Cdd:pfam02009 236 ICGTVESIVEKAESAAAAAAAAAAAEATAAAIKAETAAVEATYASYQTAIIASIVAIVVIVLIMVIIYLILRYRRKKKMK 315

                          90
                  ....*....|.
gi 574977306   89 KKLQYIKLLKE 99
Cdd:pfam02009 316 KKLQYIKLLKE 326

Rifin; Plasmodium falciparum is the causative agent of deadly malaria disease. It encodes repetitive interspersed families of polypeptides (RIFINs), which are expressed on the surface of infected erythrocytes. All RIFIN sequences contain the PEXEL motif (a pentameric sequence RxLxE/Q/D, known as the Plasmodium export element) required for correct export and surface expression or host-targeting (HT) signal which plays a central role in the export of proteins into the host cell. It has been reported that PEXEL is preferably located 15-20 amino acids downstream of an N-terminal hydrophobic signal sequence. The RIFIN protein family can be divided into A and B types based on the presence or absence of a 25 amino acid motif located approximately 66 amino acids downstream of the PEXEL motif, with A- and B-types serving different roles in distinct parasite stages. The specific type B RIFIN variant (PF13_0006) is expressed on the surface of free merozoites, internally in developing gametocytes and on the surface of gametes at the point of emerging from activated, mature stage V gametocytes. While type A RIFIN are expressed on the infected erythrocyte surface, potentially contributing to the antigenic variation capacity of the parasite.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574977306    9 IPLKAQEIVTQGTKAADAKTAEVSSRIAADITTKQTTAINSTYASYEITIIASIVAIVVIVLIMVIIYLILRYRRKTKMK 88
Cdd:pfam02009 236 ICGTVESIVEKAESAAAAAAAAAAAEATAAAIKAETAAVEATYASYQTAIIASIVAIVVIVLIMVIIYLILRYRRKKKMK 315

                          90
                  ....*....|.
gi 574977306   89 KKLQYIKLLKE 99
Cdd:pfam02009 316 KKLQYIKLLKE 326

variant surface antigen, rifin family; This model represents the rifin branch of the rifin/stevor family (pfam02009) of predicted variant surface antigens as found in Plasmodium falciparum. This model is based on a set of rifin sequences kindly provided by Matt Berriman from the Sanger Center. This is a global model and assesses a penalty for incomplete sequence. Additional fragmentary sequences may be found with the fragment model and a cutoff of 20 bits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574977306   14 QEIVTQGTKAADAKTAEVSSRIAADITTKQTTAINSTYASYEITIIASIVAIVVIVLIMVIIYLILRYRRKTKMKKKLQY 93
Cdd:TIGR01477 268 ETIVANAEDAAKAAAKAATKATTATATKATTALVEATTTNYYTPIIASIIAILIIVLIMVIIYLILRYRRKKKMKKKLQY 347

                  ....*.
gi 574977306   94 IKLLKE 99
Cdd:TIGR01477 348 IKLLNE 353

Rifin; Plasmodium falciparum is the causative agent of deadly malaria disease. It encodes repetitive interspersed families of polypeptides (RIFINs), which are expressed on the surface of infected erythrocytes. All RIFIN sequences contain the PEXEL motif (a pentameric sequence RxLxE/Q/D, known as the Plasmodium export element) required for correct export and surface expression or host-targeting (HT) signal which plays a central role in the export of proteins into the host cell. It has been reported that PEXEL is preferably located 15-20 amino acids downstream of an N-terminal hydrophobic signal sequence. The RIFIN protein family can be divided into A and B types based on the presence or absence of a 25 amino acid motif located approximately 66 amino acids downstream of the PEXEL motif, with A- and B-types serving different roles in distinct parasite stages. The specific type B RIFIN variant (PF13_0006) is expressed on the surface of free merozoites, internally in developing gametocytes and on the surface of gametes at the point of emerging from activated, mature stage V gametocytes. While type A RIFIN are expressed on the infected erythrocyte surface, potentially contributing to the antigenic variation capacity of the parasite.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574977306    9 IPLKAQEIVTQGTKAADAKTAEVSSRIAADITTKQTTAINSTYASYEITIIASIVAIVVIVLIMVIIYLILRYRRKTKMK 88
Cdd:pfam02009 236 ICGTVESIVEKAESAAAAAAAAAAAEATAAAIKAETAAVEATYASYQTAIIASIVAIVVIVLIMVIIYLILRYRRKKKMK 315

                          90
                  ....*....|.
gi 574977306   89 KKLQYIKLLKE 99
Cdd:pfam02009 316 KKLQYIKLLKE 326

variant surface antigen, rifin family; This model represents the rifin branch of the rifin/stevor family (pfam02009) of predicted variant surface antigens as found in Plasmodium falciparum. This model is based on a set of rifin sequences kindly provided by Matt Berriman from the Sanger Center. This is a global model and assesses a penalty for incomplete sequence. Additional fragmentary sequences may be found with the fragment model and a cutoff of 20 bits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574977306   14 QEIVTQGTKAADAKTAEVSSRIAADITTKQTTAINSTYASYEITIIASIVAIVVIVLIMVIIYLILRYRRKTKMKKKLQY 93
Cdd:TIGR01477 268 ETIVANAEDAAKAAAKAATKATTATATKATTALVEATTTNYYTPIIASIIAILIIVLIMVIIYLILRYRRKKKMKKKLQY 347

                  ....*.
gi 574977306   94 IKLLKE 99
Cdd:TIGR01477 348 IKLLNE 353