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Conserved domains on  [gi|5729947|ref|NP_006672|]
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neuromedin-U isoform 1 preproprotein [Homo sapiens]

Protein Classification

NMU domain-containing protein( domain architecture ID 10638104)

NMU domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
 142-166 3.47e-11

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


:

Pssm-ID: 197507  Cd Length: 25  Bit Score: 55.22  E-value: 3.47e-11
                           10        20
                   ....*....|....*....|....*
gi 5729947     142 FRVDEEFQSPFASQSRGYFLFRPRN 166
Cdd:smart00084   1 FKVDEEFQGPIASQSRGYFLFRPRN 25
 
Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
 142-166 3.47e-11

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


Pssm-ID: 197507  Cd Length: 25  Bit Score: 55.22  E-value: 3.47e-11
                           10        20
                   ....*....|....*....|....*
gi 5729947     142 FRVDEEFQSPFASQSRGYFLFRPRN 166
Cdd:smart00084   1 FKVDEEFQGPIASQSRGYFLFRPRN 25
NMU pfam02070
Neuromedin U;
142-166 1.33e-10

Neuromedin U;


Pssm-ID: 460435  Cd Length: 25  Bit Score: 53.71  E-value: 1.33e-10
                          10        20
                  ....*....|....*....|....*
gi 5729947    142 FRVDEEFQSPFASQSRGYFLFRPRN 166
Cdd:pfam02070   1 FKVDEELQGPGAIQSRGYFLFRPRN 25
 
Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
 142-166 3.47e-11

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


Pssm-ID: 197507  Cd Length: 25  Bit Score: 55.22  E-value: 3.47e-11
                           10        20
                   ....*....|....*....|....*
gi 5729947     142 FRVDEEFQSPFASQSRGYFLFRPRN 166
Cdd:smart00084   1 FKVDEEFQGPIASQSRGYFLFRPRN 25
NMU pfam02070
Neuromedin U;
142-166 1.33e-10

Neuromedin U;


Pssm-ID: 460435  Cd Length: 25  Bit Score: 53.71  E-value: 1.33e-10
                          10        20
                  ....*....|....*....|....*
gi 5729947    142 FRVDEEFQSPFASQSRGYFLFRPRN 166
Cdd:pfam02070   1 FKVDEELQGPGAIQSRGYFLFRPRN 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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