NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|5729820|ref|NP_006558|]
View 

phenylalanine--tRNA ligase, mitochondrial isoform 1 [Homo sapiens]

Protein Classification

phenylalanine--tRNA ligase( domain architecture ID 1006086)

phenylalanine--tRNA ligase catalyzes the synthesis of phenylalanyl-tRNA (Phe)

CATH:  3.30.70.380|3.30.930.10
EC:  6.1.1.20
Gene Ontology:  GO:0005524|GO:0004826|GO:0000049|GO:0006432

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PLN02788 super family cl33567
phenylalanine-tRNA synthetase
 29-450 1.34e-180

phenylalanine-tRNA synthetase


The actual alignment was detected with superfamily member PLN02788:

Pssm-ID: 215422 [Multi-domain]  Cd Length: 402  Bit Score: 510.08  E-value: 1.34e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    29 HQAWGSRPPAAECATQ-RAPG-SVVELLGKSYPQDD-------HSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYK 99
Cdd:PLN02788   4 SSALVTPATAKSSSRRyRAPAvSAVEIGGVAIARDEvvreddpTNNVPDHIFSKIGMQLHRRPDHPLGILKNAIYDYFDE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   100 QYVGrfgtpLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYR 179
Cdd:PLN02788  84 NYSN-----KFKKFDDLSPIVSTKQNFDDVLVPPDHVSRSYNDTYYVDAQTVLRCHTSAHQAELLRAGHTHFLVTGDVYR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   180 RDQIDSQHYPIFHQLEAVRLFSKHELfagikdgeslqlfeqssrsahkqETHTMEAVKLVEFDLKQTLTRLMAHLFGDeL 259
Cdd:PLN02788 159 RDSIDATHYPVFHQMEGVRVFSPEEW-----------------------EASGLDGTDLAAEDLKKTLEGLARHLFGD-V 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   260 EIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERF 339
Cdd:PLN02788 215 EMRWVDAYFPFTNPSFELEIFFKGEWLEVLGCGVTEQEILKNNGRSDNVAWAFGLGLERLAMVLFDIPDIRLFWSDDERF 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   340 LKQFCVSNInqKVKFQPLSKYPAVINDISFWLPSEnYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYR 419
Cdd:PLN02788 295 TSQFKEGQL--GVKFKPYSKYPPCYKDISFWISDE-FTENNLCEVVRGIAGDLVEEVKLIDNFTNPKKGKTSHCYRIVYR 371

                        410       420       430
                 ....*....|....*....|....*....|.
gi 5729820   420 HMERTLSQREVRHIHQALQEAAVQLLGVEGR 450
Cdd:PLN02788 372 SMERSLTDEEINALQDKVREEVQKKLGVELR 402
 
Name Accession Description Interval E-value
PLN02788 PLN02788
phenylalanine-tRNA synthetase
 29-450 1.34e-180

phenylalanine-tRNA synthetase


Pssm-ID: 215422 [Multi-domain]  Cd Length: 402  Bit Score: 510.08  E-value: 1.34e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    29 HQAWGSRPPAAECATQ-RAPG-SVVELLGKSYPQDD-------HSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYK 99
Cdd:PLN02788   4 SSALVTPATAKSSSRRyRAPAvSAVEIGGVAIARDEvvreddpTNNVPDHIFSKIGMQLHRRPDHPLGILKNAIYDYFDE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   100 QYVGrfgtpLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYR 179
Cdd:PLN02788  84 NYSN-----KFKKFDDLSPIVSTKQNFDDVLVPPDHVSRSYNDTYYVDAQTVLRCHTSAHQAELLRAGHTHFLVTGDVYR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   180 RDQIDSQHYPIFHQLEAVRLFSKHELfagikdgeslqlfeqssrsahkqETHTMEAVKLVEFDLKQTLTRLMAHLFGDeL 259
Cdd:PLN02788 159 RDSIDATHYPVFHQMEGVRVFSPEEW-----------------------EASGLDGTDLAAEDLKKTLEGLARHLFGD-V 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   260 EIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERF 339
Cdd:PLN02788 215 EMRWVDAYFPFTNPSFELEIFFKGEWLEVLGCGVTEQEILKNNGRSDNVAWAFGLGLERLAMVLFDIPDIRLFWSDDERF 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   340 LKQFCVSNInqKVKFQPLSKYPAVINDISFWLPSEnYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYR 419
Cdd:PLN02788 295 TSQFKEGQL--GVKFKPYSKYPPCYKDISFWISDE-FTENNLCEVVRGIAGDLVEEVKLIDNFTNPKKGKTSHCYRIVYR 371

                        410       420       430
                 ....*....|....*....|....*....|.
gi 5729820   420 HMERTLSQREVRHIHQALQEAAVQLLGVEGR 450
Cdd:PLN02788 372 SMERSLTDEEINALQDKVREEVQKKLGVELR 402
pheS_mito TIGR00469
phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA ...
 51-448 1.07e-156

phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA synthetases, the mitochondrial form demonstrated from yeast is monomeric. It is similar to but longer than the alpha subunit (PheS) of the alpha 2 beta 2 form found in Bacteria, Archaea, and eukaryotes, and shares the characteristic motifs of class II aminoacyl-tRNA ligases. This model models the experimental example from Saccharomyces cerevisiae (designated MSF1) and its orthologs from other eukaryotic species. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 129561 [Multi-domain]  Cd Length: 460  Bit Score: 451.84  E-value: 1.07e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820     51 VELLGKSYPQDDHS-NLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSL 129
Cdd:TIGR00469   8 LEINGIKYATDGQTtNVTDKIIKLTDANKHLKEDHPLGIIRDLIEKKFNGADNNQRGNPLFKIFDNFKPVVTTMENFDNL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    130 LIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLD-------AFLVVGDVYRRDQIDSQHYPIFHQLE--AVRLF 200
Cdd:TIGR00469  88 GFPADHPGRQKSDCYYINEQHLLRAHTSAHELECFQGGLDdsdniksGFLISADVYRRDEIDKTHYPVFHQADgaAIRKR 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    201 SKHELFagIKDGESLQLFEQSSRSAH------------------------KQETHTMEAVKLVEFDLKQTLTRLMAHLFG 256
Cdd:TIGR00469 168 TKADLF--EKEPGYIEKFEEDIRGTEadlnkenvkiildddsiplkennpKQEYASDLAVDLCEHELKHSIEGITKDLFG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    257 ---------------DELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQ--DRIGWAFGLGLERL 319
Cdd:TIGR00469 246 kkissmiknkanntpKELKVRWIDAYFPFTAPSWEIEIWFKDEWLELCGCGIIRHDILLRAGVHpsETIGWAFGLGLDRI 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    320 AMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSE-----NYAENDFYDLVRTIGGDLVE 394
Cdd:TIGR00469 326 AMLLFDIPDIRLFWSNDEGFLRQFSEGDLHLIPKFKPISHHPGCFNDLAFWLPEDieddaGFHENDFMDIIRNIAGDLVE 405

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 5729820    395 KVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVE 448
Cdd:TIGR00469 406 QIKLVDKFKHPKTGKKSMCFRINYQHMDRNLTNAEVNEIHDMIASALVDEFNVE 459
PheRS_alpha_core cd00496
Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class ...
 84-338 1.81e-94

Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer.


Pssm-ID: 238277 [Multi-domain]  Cd Length: 218  Bit Score: 284.05  E-value: 1.81e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   84 HPLWLIKERVKEHFYKQyvgrfgtpLFSVYDNlSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRT--HMLRAHTSAHQW 161
Cdd:cd00496   1 HPLNKVIEEIEDIFVSM--------GFTEVEG-PEVETDFYNFDALNIPQDHPARDMQDTFYINDParLLLRTHTSAVQA 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  162 DLLHA--GLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKhelfagikdgeslqlfeqssrsahkqethtmeavkLV 239
Cdd:cd00496  72 RALAKlkPPIRIFSIGRVYRNDEIDATHLPEFHQIEGLVVDKG-----------------------------------LT 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  240 EFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHG--EWLEVLGCGVMEQQLVNSAGAQ-DRIGWAFGLGL 316
Cdd:cd00496 117 FADLKGTLEEFAKELFGPITKVRFRPSYFPFTEPSFEVDVYCPGclGWLEILGCGMVRPEVLENAGIDeEYSGFAFGIGL 196

                       250       260
                ....*....|....*....|..
gi 5729820  317 ERLAMILYDIPDIRLFWCEDER 338
Cdd:cd00496 197 ERLAMLKYGIPDIRLFYSNDLR 218
PheS COG0016
Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; ...
 84-343 8.73e-53

Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase alpha subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439787 [Multi-domain]  Cd Length: 339  Bit Score: 180.25  E-value: 8.73e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   84 HPLWLIKERVKEHFykqyvGRFGtplFSVYDnlSP-VVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQwd 162
Cdd:COG0016 107 HPLTQVIEEIEDIF-----VGMG---FEVAE--GPeIETDWYNFEALNIPPDHPARDMQDTFYIDDGLLLRTHTSPVQ-- 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  163 lLHAGLD-----AFLVVGDVYRRDQIDSQHYPIFHQLE--AVrlfSKHELFAgikdgeslqlfeqssrsahkqethtmea 235
Cdd:COG0016 175 -IRTMEKqkppiRIIAPGRVYRRDESDATHSPMFHQVEglVV---DKGISFA---------------------------- 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  236 vklvefDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINF------------HGEWLEVLGCG-----VMEqql 298
Cdd:COG0016 223 ------DLKGTLEEFAKAFFGEDVKVRFRPSYFPFTEPSAEVDISCficggkgcrvckGTGWLEILGCGmvhpnVLR--- 293

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 5729820  299 vnSAGaqdrI------GWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQF 343
Cdd:COG0016 294 --AVG----IdpeeysGFAFGMGIERLAMLKYGIDDIRLFFENDLRFLRQF 338
tRNA-synt_2d pfam01409
tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too ...
 83-343 8.11e-49

tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.


Pssm-ID: 396130 [Multi-domain]  Cd Length: 245  Bit Score: 166.99  E-value: 8.11e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820     83 HHPLWLIKERVKEHFYkqyvgRFGtplFSVYDNlSPVVTTWQNFDSLLIPADHPSRKKGDNYYL-------NRTHMLRAH 155
Cdd:pfam01409  16 LHPLTRTLERIRDIFL-----GMG---FEEVEG-PEVESDFYNFDALNIPQDHPARDMQDTFYLkkplkpvARRLLLRTH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    156 TSAHQWDLLHAGLDA---FLVVGDVYRRDQIDSQHYPIFHQLEAVRlfskhelfagIKDGESLQlfeqssrsahkqetht 232
Cdd:pfam01409  87 TTPVQARTLAKKPKPpikIFSIGRVFRRDQVDATHLPEFHQVEGLV----------VDENVTFA---------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    233 meavklvefDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINF--HGEWLEVLGCGVMEQQLVNSAG-AQDRIG 309
Cdd:pfam01409 141 ---------DLKGVLEEFLRKFFGFEVKVRFRPSYFPFTEPSAEVDVYVckLGGWLEVGGAGMVHPNVLEAVGiDEDYSG 211

                         250       260       270
                  ....*....|....*....|....*....|....
gi 5729820    310 WAFGLGLERLAMILYDIPDIRLFWCEDERFLKQF 343
Cdd:pfam01409 212 FAFGLGVERLAMLKYGIDDIRDLYENDLRFLRQF 245
FDX-ACB smart00896
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ...
 358-450 4.04e-31

Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2).


Pssm-ID: 214893 [Multi-domain]  Cd Length: 93  Bit Score: 114.83  E-value: 4.04e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820     358 SKYPAVINDISFWLPsENYAENDFYDLVRTIGGDLVEKVDLIDKFVH-PKTHKTSHCYRITYRHMERTLSQREVRHIHQA 436
Cdd:smart00896   1 SKFPAVRRDLAFVVD-EDVPAAELLDAIREAGGDLLEDVRLFDVYEGgIPEGKKSLAYRLTYQSPDRTLTDEEVNAIHDK 79

                           90
                   ....*....|....
gi 5729820     437 LQEAAVQLLGVEGR 450
Cdd:smart00896  80 IVAALEKKFGAELR 93
 
Name Accession Description Interval E-value
PLN02788 PLN02788
phenylalanine-tRNA synthetase
 29-450 1.34e-180

phenylalanine-tRNA synthetase


Pssm-ID: 215422 [Multi-domain]  Cd Length: 402  Bit Score: 510.08  E-value: 1.34e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    29 HQAWGSRPPAAECATQ-RAPG-SVVELLGKSYPQDD-------HSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYK 99
Cdd:PLN02788   4 SSALVTPATAKSSSRRyRAPAvSAVEIGGVAIARDEvvreddpTNNVPDHIFSKIGMQLHRRPDHPLGILKNAIYDYFDE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   100 QYVGrfgtpLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYR 179
Cdd:PLN02788  84 NYSN-----KFKKFDDLSPIVSTKQNFDDVLVPPDHVSRSYNDTYYVDAQTVLRCHTSAHQAELLRAGHTHFLVTGDVYR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   180 RDQIDSQHYPIFHQLEAVRLFSKHELfagikdgeslqlfeqssrsahkqETHTMEAVKLVEFDLKQTLTRLMAHLFGDeL 259
Cdd:PLN02788 159 RDSIDATHYPVFHQMEGVRVFSPEEW-----------------------EASGLDGTDLAAEDLKKTLEGLARHLFGD-V 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   260 EIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERF 339
Cdd:PLN02788 215 EMRWVDAYFPFTNPSFELEIFFKGEWLEVLGCGVTEQEILKNNGRSDNVAWAFGLGLERLAMVLFDIPDIRLFWSDDERF 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   340 LKQFCVSNInqKVKFQPLSKYPAVINDISFWLPSEnYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYR 419
Cdd:PLN02788 295 TSQFKEGQL--GVKFKPYSKYPPCYKDISFWISDE-FTENNLCEVVRGIAGDLVEEVKLIDNFTNPKKGKTSHCYRIVYR 371

                        410       420       430
                 ....*....|....*....|....*....|.
gi 5729820   420 HMERTLSQREVRHIHQALQEAAVQLLGVEGR 450
Cdd:PLN02788 372 SMERSLTDEEINALQDKVREEVQKKLGVELR 402
pheS_mito TIGR00469
phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA ...
 51-448 1.07e-156

phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA synthetases, the mitochondrial form demonstrated from yeast is monomeric. It is similar to but longer than the alpha subunit (PheS) of the alpha 2 beta 2 form found in Bacteria, Archaea, and eukaryotes, and shares the characteristic motifs of class II aminoacyl-tRNA ligases. This model models the experimental example from Saccharomyces cerevisiae (designated MSF1) and its orthologs from other eukaryotic species. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 129561 [Multi-domain]  Cd Length: 460  Bit Score: 451.84  E-value: 1.07e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820     51 VELLGKSYPQDDHS-NLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSL 129
Cdd:TIGR00469   8 LEINGIKYATDGQTtNVTDKIIKLTDANKHLKEDHPLGIIRDLIEKKFNGADNNQRGNPLFKIFDNFKPVVTTMENFDNL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    130 LIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLD-------AFLVVGDVYRRDQIDSQHYPIFHQLE--AVRLF 200
Cdd:TIGR00469  88 GFPADHPGRQKSDCYYINEQHLLRAHTSAHELECFQGGLDdsdniksGFLISADVYRRDEIDKTHYPVFHQADgaAIRKR 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    201 SKHELFagIKDGESLQLFEQSSRSAH------------------------KQETHTMEAVKLVEFDLKQTLTRLMAHLFG 256
Cdd:TIGR00469 168 TKADLF--EKEPGYIEKFEEDIRGTEadlnkenvkiildddsiplkennpKQEYASDLAVDLCEHELKHSIEGITKDLFG 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    257 ---------------DELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQ--DRIGWAFGLGLERL 319
Cdd:TIGR00469 246 kkissmiknkanntpKELKVRWIDAYFPFTAPSWEIEIWFKDEWLELCGCGIIRHDILLRAGVHpsETIGWAFGLGLDRI 325

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    320 AMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSE-----NYAENDFYDLVRTIGGDLVE 394
Cdd:TIGR00469 326 AMLLFDIPDIRLFWSNDEGFLRQFSEGDLHLIPKFKPISHHPGCFNDLAFWLPEDieddaGFHENDFMDIIRNIAGDLVE 405

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 5729820    395 KVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVE 448
Cdd:TIGR00469 406 QIKLVDKFKHPKTGKKSMCFRINYQHMDRNLTNAEVNEIHDMIASALVDEFNVE 459
PheRS_alpha_core cd00496
Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class ...
 84-338 1.81e-94

Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer.


Pssm-ID: 238277 [Multi-domain]  Cd Length: 218  Bit Score: 284.05  E-value: 1.81e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   84 HPLWLIKERVKEHFYKQyvgrfgtpLFSVYDNlSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRT--HMLRAHTSAHQW 161
Cdd:cd00496   1 HPLNKVIEEIEDIFVSM--------GFTEVEG-PEVETDFYNFDALNIPQDHPARDMQDTFYINDParLLLRTHTSAVQA 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  162 DLLHA--GLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKhelfagikdgeslqlfeqssrsahkqethtmeavkLV 239
Cdd:cd00496  72 RALAKlkPPIRIFSIGRVYRNDEIDATHLPEFHQIEGLVVDKG-----------------------------------LT 116

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  240 EFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHG--EWLEVLGCGVMEQQLVNSAGAQ-DRIGWAFGLGL 316
Cdd:cd00496 117 FADLKGTLEEFAKELFGPITKVRFRPSYFPFTEPSFEVDVYCPGclGWLEILGCGMVRPEVLENAGIDeEYSGFAFGIGL 196

                       250       260
                ....*....|....*....|..
gi 5729820  317 ERLAMILYDIPDIRLFWCEDER 338
Cdd:cd00496 197 ERLAMLKYGIPDIRLFYSNDLR 218
PheS COG0016
Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; ...
 84-343 8.73e-53

Phenylalanyl-tRNA synthetase alpha subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase alpha subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439787 [Multi-domain]  Cd Length: 339  Bit Score: 180.25  E-value: 8.73e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   84 HPLWLIKERVKEHFykqyvGRFGtplFSVYDnlSP-VVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQwd 162
Cdd:COG0016 107 HPLTQVIEEIEDIF-----VGMG---FEVAE--GPeIETDWYNFEALNIPPDHPARDMQDTFYIDDGLLLRTHTSPVQ-- 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  163 lLHAGLD-----AFLVVGDVYRRDQIDSQHYPIFHQLE--AVrlfSKHELFAgikdgeslqlfeqssrsahkqethtmea 235
Cdd:COG0016 175 -IRTMEKqkppiRIIAPGRVYRRDESDATHSPMFHQVEglVV---DKGISFA---------------------------- 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  236 vklvefDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINF------------HGEWLEVLGCG-----VMEqql 298
Cdd:COG0016 223 ------DLKGTLEEFAKAFFGEDVKVRFRPSYFPFTEPSAEVDISCficggkgcrvckGTGWLEILGCGmvhpnVLR--- 293

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 5729820  299 vnSAGaqdrI------GWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQF 343
Cdd:COG0016 294 --AVG----IdpeeysGFAFGMGIERLAMLKYGIDDIRLFFENDLRFLRQF 338
tRNA-synt_2d pfam01409
tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too ...
 83-343 8.11e-49

tRNA synthetases class II core domain (F); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only phenylalanyl-tRNA synthetases. This is the core catalytic domain.


Pssm-ID: 396130 [Multi-domain]  Cd Length: 245  Bit Score: 166.99  E-value: 8.11e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820     83 HHPLWLIKERVKEHFYkqyvgRFGtplFSVYDNlSPVVTTWQNFDSLLIPADHPSRKKGDNYYL-------NRTHMLRAH 155
Cdd:pfam01409  16 LHPLTRTLERIRDIFL-----GMG---FEEVEG-PEVESDFYNFDALNIPQDHPARDMQDTFYLkkplkpvARRLLLRTH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    156 TSAHQWDLLHAGLDA---FLVVGDVYRRDQIDSQHYPIFHQLEAVRlfskhelfagIKDGESLQlfeqssrsahkqetht 232
Cdd:pfam01409  87 TTPVQARTLAKKPKPpikIFSIGRVFRRDQVDATHLPEFHQVEGLV----------VDENVTFA---------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    233 meavklvefDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINF--HGEWLEVLGCGVMEQQLVNSAG-AQDRIG 309
Cdd:pfam01409 141 ---------DLKGVLEEFLRKFFGFEVKVRFRPSYFPFTEPSAEVDVYVckLGGWLEVGGAGMVHPNVLEAVGiDEDYSG 211

                         250       260       270
                  ....*....|....*....|....*....|....
gi 5729820    310 WAFGLGLERLAMILYDIPDIRLFWCEDERFLKQF 343
Cdd:pfam01409 212 FAFGLGVERLAMLKYGIDDIRDLYENDLRFLRQF 245
pheS TIGR00468
phenylalanyl-tRNA synthetase, alpha subunit; Most phenylalanyl-tRNA synthetases are ...
 84-343 1.03e-48

phenylalanyl-tRNA synthetase, alpha subunit; Most phenylalanyl-tRNA synthetases are heterodimeric, with 2 alpha (pheS) and 2 beta (pheT) subunits. This model describes the alpha subunit, which shows some similarity to class II aminoacyl-tRNA ligases. Mitochondrial phenylalanyl-tRNA synthetase is a single polypeptide chain, active as a monomer, and similar to this chain rather than to the beta chain, but excluded from this model. An interesting feature of the alignment of all sequences captured by this model is a deep split between non-spirochete bacterial examples and all other examples; supporting this split is a relative deletion of about 50 residues in the former set between two motifs well conserved throughout the alignment. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273095 [Multi-domain]  Cd Length: 293  Bit Score: 168.26  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820     84 HPLWLIKERVKEHFYKqyvgrFGtplFSVydNLSPVVTT-WQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQwd 162
Cdd:TIGR00468  72 HPLTRVIDEIRDIFLG-----LG---FTE--ETGPEVETdFWNFDALNIPQDHPARDMQDTFYIKDRLLLRTHTTAVQ-- 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    163 lLHAGLDA------FLVVGDVYRRDQIDSQHYPIFHQLEAVRlfskhelfagIKDGESLQlfeqssrsahkqethtmeav 236
Cdd:TIGR00468 140 -LRTMEEQekppirIFSPGRVFRNDTVDATHLPEFHQVEGLV----------IDKNISFT-------------------- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    237 klvefDLKQTLtRLMAHLFGDELEIRWVDCYFPFTHPSFEMEInFHGE---WLEVLGCGVMEQQLVNSAGAQDRI-GWAF 312
Cdd:TIGR00468 189 -----NLKGFL-EEFLKKMFGETEIRFRPSYFPFTEPSAEIDV-YCPEgkgWLEVLGAGMFRPEVLEPMGIDPTYpGFAW 261

                         250       260       270
                  ....*....|....*....|....*....|.
gi 5729820    313 GLGLERLAMILYDIPDIRLFWCEDERFLKQF 343
Cdd:TIGR00468 262 GIGIERLAMLKYGITDIRDLYENDLRFLRQF 292
FDX-ACB smart00896
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ...
 358-450 4.04e-31

Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2).


Pssm-ID: 214893 [Multi-domain]  Cd Length: 93  Bit Score: 114.83  E-value: 4.04e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820     358 SKYPAVINDISFWLPsENYAENDFYDLVRTIGGDLVEKVDLIDKFVH-PKTHKTSHCYRITYRHMERTLSQREVRHIHQA 436
Cdd:smart00896   1 SKFPAVRRDLAFVVD-EDVPAAELLDAIREAGGDLLEDVRLFDVYEGgIPEGKKSLAYRLTYQSPDRTLTDEEVNAIHDK 79

                           90
                   ....*....|....
gi 5729820     437 LQEAAVQLLGVEGR 450
Cdd:smart00896  80 IVAALEKKFGAELR 93
pheS PRK04172
phenylalanine--tRNA ligase subunit alpha;
117-332 2.73e-24

phenylalanine--tRNA ligase subunit alpha;


Pssm-ID: 235239 [Multi-domain]  Cd Length: 489  Bit Score: 104.91  E-value: 2.73e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   117 SPVVTT--WqNFDSLLIPADHPSRKKGDNYYLN----------------RTH-----------------------MLRAH 155
Cdd:PRK04172 256 GPLVETefW-NFDALFQPQDHPAREMQDTFYLKypgigdlpeelvervkEVHehggdtgsrgwgykwdediakrlVLRTH 334

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   156 T---SAHQwdlLHAGLDA---FLVVGDVYRRDQIDSQHYPIFHQLEavrlfskhelfaGIKDGESLqlfeqssrsahkqe 229
Cdd:PRK04172 335 TtalSARY---LASRPEPpqkYFSIGRVFRPDTIDATHLPEFYQLE------------GIVMGEDV-------------- 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   230 thtmeAVKlvefDLKQTLTRlMAHLFGDElEIRWVDCYFPFTHPSFEMEInFH--GEWLEVLGCGVMEQQLVNSAGAQDR 307
Cdd:PRK04172 386 -----SFR----DLLGILKE-FYKRLGFE-EVKFRPAYFPFTEPSVEVEV-YHegLGWVELGGAGIFRPEVLEPLGIDVP 453

                        250       260
                 ....*....|....*....|....*.
gi 5729820   308 IGwAFGLGLERLAMILYDIPDIR-LF 332
Cdd:PRK04172 454 VL-AWGLGIERLAMLRLGLDDIRdLY 478
FDX-ACB pfam03147
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ...
 358-450 6.58e-22

Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold.


Pssm-ID: 460826 [Multi-domain]  Cd Length: 94  Bit Score: 89.46  E-value: 6.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    358 SKYPAVINDISFWLPsENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPK--THKTSHCYRITYRHMERTLSQREVRHIHQ 435
Cdd:pfam03147   1 SKYPAVRRDLAFVVD-EDVPAADILKAIREAGGELLESVELFDVYRGEKipEGKKSLAFRLTFQSPERTLTDEEVNAIIE 79

                          90
                  ....*....|....*
gi 5729820    436 ALQEAAVQLLGVEGR 450
Cdd:pfam03147  80 KIVEALEKKFGAELR 94
pheT_bact TIGR00472
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ...
 241-450 1.80e-15

phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273097 [Multi-domain]  Cd Length: 797  Bit Score: 78.87  E-value: 1.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    241 FDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEwleVLGC-GVMEQQLVNSAGAQDRIgWAFGLGLERL 319
Cdd:TIGR00472 615 YDLKGDVESLLELLGLSDDVYFKNTAENEELHPGQSATIYLKGK---KIGFiGELHPEIAKKYDLKEPT-FVFELDLDRL 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820    320 AMILYDIPdirlfwcederflkqfcvsninqkvKFQPLSKYPAVINDISFWLPSENYAeNDFYDLVRTIGGDLVEKVDLI 399
Cdd:TIGR00472 691 LESLKKVP-------------------------KYRPISKFPAVTRDISFLVPKDVPA-NEIIKLIKKSGLELLEEVELF 744

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 5729820    400 DKFV--HPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGR 450
Cdd:TIGR00472 745 DVYQgkNIGEGKKSLALRLVLRDKERTLTDEEINKIVEKVLNALKEKLGAELR 797
pheT PRK00629
phenylalanyl-tRNA synthetase subunit beta; Reviewed
 351-448 1.26e-14

phenylalanyl-tRNA synthetase subunit beta; Reviewed


Pssm-ID: 234804 [Multi-domain]  Cd Length: 791  Bit Score: 76.36  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   351 KVKFQPLSKYPAVINDISFWLPsENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPK--THKTSHCYRITYRHMERTLSQR 428
Cdd:PRK00629 690 LPKYKPISKFPAVRRDLALVVD-EDVPAADILKAIKKAGGKLLESVELFDVYEGKGigEGKKSLAFRLTFQDPDRTLTDE 768

                         90       100
                 ....*....|....*....|
gi 5729820   429 EVRHIHQALQEAAVQLLGVE 448
Cdd:PRK00629 769 EINAAMDKIVAALEEKFGAE 788
PheT COG0072
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ...
 345-448 4.15e-14

Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439842 [Multi-domain]  Cd Length: 793  Bit Score: 74.43  E-value: 4.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820  345 VSNINQKVKFQPLSKYPAVINDISFWLPsENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPK--THKTSHCYRITYRHME 422
Cdd:COG0072 686 LELARKVPKYKPISKFPAVRRDLALVVD-EDVPAADVLDAIRKAAGKLLEDVRLFDVYEGKGvpEGKKSLAFSLTLQDPD 764

                        90       100
                ....*....|....*....|....*.
gi 5729820  423 RTLSQREVRHIHQALQEAAVQLLGVE 448
Cdd:COG0072 765 RTLTDEEIDAAMDKIVAALEKKFGAE 790
PLN02853 PLN02853
Probable phenylalanyl-tRNA synthetase alpha chain
 123-332 1.24e-08

Probable phenylalanyl-tRNA synthetase alpha chain


Pssm-ID: 215458 [Multi-domain]  Cd Length: 492  Bit Score: 56.99  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   123 WqNFDSLLIPADHPSRKKGDNYYLN-----------------RTH----------------------MLRAHTSAHQWDL 163
Cdd:PLN02853 253 W-NFDALFQPQQHPARDSHDTFFLKapattrqlpedyvervkTVHesggygsigygydwkreeanknLLRTHTTAVSSRM 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   164 LHA-GLDAF-----LVVGDVYRRDQIDSQHYPIFHQLEAVrlfskhelfagIKD-GESLQlfeqssrsahkqethtmeav 236
Cdd:PLN02853 332 LYKlAQKGFkpkryFSIDRVFRNEAVDRTHLAEFHQVEGL-----------VCDrGLTLG-------------------- 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   237 klvefDLKQTLTRLMAHLFGDELeiRWVDCYFPFTHPSfeMEI-NFH---GEWLEVLGCGVMEQQLVNSAGAQDR---IG 309
Cdd:PLN02853 381 -----DLIGVLEDFFSRLGMTKL--RFKPAYNPYTEPS--MEIfSYHeglKKWVEVGNSGMFRPEMLLPMGLPEDvnvIA 451

                        250       260
                 ....*....|....*....|....
gi 5729820   310 WafGLGLERLAMILYDIPDIR-LF 332
Cdd:PLN02853 452 W--GLSLERPTMILYGIDNIRdLF 473
PTZ00326 PTZ00326
phenylalanyl-tRNA synthetase alpha chain; Provisional
 123-332 4.23e-07

phenylalanyl-tRNA synthetase alpha chain; Provisional


Pssm-ID: 240361 [Multi-domain]  Cd Length: 494  Bit Score: 52.28  E-value: 4.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   123 WqNFDSLLIPADHPSR----------------KKGDNYYLNR---TH----------------------MLRAHTSAHQW 161
Cdd:PTZ00326 261 W-NFDALFQPQQHPARdaqdtfflskpetskvNDLDDDYVERvkkVHevggygsigwrydwkleearknILRTHTTAVSA 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   162 DLLH-------AGLD----AFLVVGDVYRRDQIDSQHYPIFHQLEAVrlfskhelfagikdgeslqlfeqssrsahkqet 230
Cdd:PTZ00326 340 RMLYklaqeykKTGPfkpkKYFSIDRVFRNETLDATHLAEFHQVEGF--------------------------------- 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   231 htmeavkLVEFDLkqTLTRLMA--HLFGDELEI---RWVDCYFPFTHPSfeMEI-NFH---GEWLEVLGCGVMEQQLVNS 301
Cdd:PTZ00326 387 -------VIDRNL--TLGDLIGtiREFFRRIGItklRFKPAFNPYTEPS--MEIfGYHpglKKWVEVGNSGIFRPEMLRP 455

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 5729820   302 AGAQDR---IGWafGLGLERLAMILYDIPDIR-LF 332
Cdd:PTZ00326 456 MGFPEDvtvIAW--GLSLERPTMIKYGIKNIRdLF 488
syfB CHL00192
phenylalanyl-tRNA synthetase beta chain; Provisional
 354-450 5.36e-07

phenylalanyl-tRNA synthetase beta chain; Provisional


Pssm-ID: 214391 [Multi-domain]  Cd Length: 704  Bit Score: 52.01  E-value: 5.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729820   354 FQPLSKYPAVINDISFWLPsENYAENDFYDLVRTIGGDLVEKVDLIDKFVHP--KTHKTSHCYRITYRHMERTLSQREVR 431
Cdd:CHL00192 606 YQPYSSYPKIIRDLSFIIK-KSISISKIKELIYQNGDNLLESITLFDYYKGKsiPNGHTSLGLRLTFQSENKTLTNEEID 684

                         90
                 ....*....|....*....
gi 5729820   432 HIHQALQEAAVQLLGVEGR 450
Cdd:CHL00192 685 RIQQNLQKVLEKKLNAEIR 703
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH