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treacle protein isoform c [Homo sapiens]
Protein Classification
WD40 repeat domain-containing protein ( domain architecture ID 12218018 )
WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly
List of domain hits
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
387-904
7.52e-75
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 255.77
E-value: 7.52e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 387 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 460
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 461 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 536
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 537 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 612
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 613 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 689
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 690 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 769
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 770 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKPP V R N PQNS TVLA RG P ASVP S 849
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKPP A R T PQNS AISV RG Q ASVP A 473
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 850 VGKAVATAAQAQ T GP EEDSG --- S SEE E SD S EE E A E TL AQ V KPSGKT H Q I RAA L APAK 904
Cdd:pfam03546 474 VGKAVATAAQAQ K GP VGGPQ eed S ESS E EE S DS E E E AP AQ A KPSGKT P Q V RAA S APAK 531
Treacle super family
cl25490 Treacher Collins syndrome protein Treacle;
212-511
2.35e-09
Treacher Collins syndrome protein Treacle;
pfam03546 :Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 60.86
E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 212 VEG KP SV K PA Q V KAS S -------- V S T K ES P A R KAA PAP G K V G D VT PQVKGGALPP A KR A KK PEE E S E SSEE GSES EE E A 283
Cdd:pfam03546 252 AQA KP AL K TP Q T KAS P rkgtpitp T S A K VP P V R VGT PAP W K A G T VT SPACASSPAV A RG A QR PEE D S S SSEE SESE EE T A 331
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 284 PA GTRS Q V K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q A K 363
Cdd:pfam03546 332 PA AAVG Q A K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q V K 406
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 364 ASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A pa 443
Cdd:pfam03546 407 ASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V -- 465
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 444 kesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 511
Cdd:pfam03546 466 ---- R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
1.85e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|..
gi 57164979 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
387-904
7.52e-75
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 255.77
E-value: 7.52e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 387 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 460
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 461 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 536
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 537 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 612
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 613 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 689
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 690 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 769
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 770 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKPP V R N PQNS TVLA RG P ASVP S 849
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKPP A R T PQNS AISV RG Q ASVP A 473
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 850 VGKAVATAAQAQ T GP EEDSG --- S SEE E SD S EE E A E TL AQ V KPSGKT H Q I RAA L APAK 904
Cdd:pfam03546 474 VGKAVATAAQAQ K GP VGGPQ eed S ESS E EE S DS E E E AP AQ A KPSGKT P Q V RAA S APAK 531
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
212-511
2.35e-09
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 60.86
E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 212 VEG KP SV K PA Q V KAS S -------- V S T K ES P A R KAA PAP G K V G D VT PQVKGGALPP A KR A KK PEE E S E SSEE GSES EE E A 283
Cdd:pfam03546 252 AQA KP AL K TP Q T KAS P rkgtpitp T S A K VP P V R VGT PAP W K A G T VT SPACASSPAV A RG A QR PEE D S S SSEE SESE EE T A 331
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 284 PA GTRS Q V K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q A K 363
Cdd:pfam03546 332 PA AAVG Q A K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q V K 406
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 364 ASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A pa 443
Cdd:pfam03546 407 ASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V -- 465
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 444 kesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 511
Cdd:pfam03546 466 ---- R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
PHA03247
PHA03247 large tegument protein UL36; Provisional
157-535
3.14e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.40
E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 157 P RK S AE P S AN TTLVSETEEEGSVPAFGAAAK PG M VS AGQADSSSEDTSSS S DETDVEGKPSVK P AQVKAS S VSTKES P AR 236
Cdd:PHA03247 2627 P PP S PS P A AN EPDPHPPPTVPPPERPRDDPA PG R VS RPRRARRLGRAAQA S SPPQRPRRRAAR P TVGSLT S LADPPP P PP 2706
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 237 KAA PAP gkvgdv TPQ V KGGA LPP AKR A KKPEEESESSEEGSESEEEA PA GTRSQVKASEKILQVRAASAPAKGT P GK G AT 316
Cdd:PHA03247 2707 TPE PAP ------ HAL V SATP LPP GPA A ARQASPALPAAPAPPAVPAG PA TPGGPARPARPPTTAGPPAPAPPAA P AA G PP 2780
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 317 PAPPGK A G A VA S QTKAGK P EEDSESSSEESSDSEEETPAAK A LLQAKASGK TS QVGA A SA P AKE sprkga A P A P PGKT G P 396
Cdd:PHA03247 2781 RRLTRP A V A SL S ESRESL P SPWDPADPPAAVLAPAAALPPA A SPAGPLPPP TS AQPT A PP P PPG ------ P P P P SLPL G G 2854
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 397 A VA KAQAGK R EED S Q S SSEESDSEEEA P AQ --- AKPSGKAPQVR A ASAPAK E S P RKGA AP A PP RKTGPAAAQV Q vgkqe E 473
Cdd:PHA03247 2855 S VA PGGDVR R RPP S R S PAAKPAAPARP P VR rla RPAVSRSTESF A LPPDQP E R P PQPQ AP P PP QPQPQPPPPP Q ----- P 2929
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57164979 474 DSRSSSEESDSDRE A LAAMN A AQVK P L G KS PQ VK pastmg M G P L GK G AGP VP PGK V GPAT PS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPL A PTTDP A GAGE P S G AV PQ PW ------ L G A L VP G RVA VP RFR V PQPA PS 2985
PHA03247
PHA03247 large tegument protein UL36; Provisional
234-676
4.95e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 47.63
E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 234 P ARKA AP A P GKVGDVTPQVKGG A L P PAK R AKK P EEESESSEEGSESEEEA P AGTRSQVKASE kilqv RAAS A PAKGTPGK 313
Cdd:PHA03247 2569 P PPRP AP R P SEPAVTSRARRPD A P P QSA R PRA P VDDRGDPRGPAPPSPLP P DTHAPDPPPPS ----- PSPA A NEPDPHPP 2643
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 314 GAT P A P PGKAGA v ASQTKAGK P EEDSESSSEESSD S EEET P AAK A LLQAKA S GKTSQVGAASA P AK E SPRKGAAP A P P GK 393
Cdd:PHA03247 2644 PTV P P P ERPRDD - PAPGRVSR P RRARRLGRAAQAS S PPQR P RRR A ARPTVG S LTSLADPPPPP P TP E PAPHALVS A T P LP 2722
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 394 T GPA V A KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA A S AP akes P RKG AA PA P P R K T G PA A A QVQVGKQEE 473
Cdd:PHA03247 2723 P GPA A A RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP A P AP ---- P AAP AA GP P R R L T R PA V A SLSESRESL 2798
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 474 D S RSSSEESDSDRE A L AA MNAAQVK P L G KS P qvk P ASTMGMGPLGKGA GP V PP ----- G K V G P ATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 P S PWDPADPPAAVL A P AA ALPPAAS P A G PL P --- P PTSAQPTAPPPPP GP P PP slplg G S V A P GGDVRRRPPSRSPAAKP 2875
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 549 SEESSDSSDGEVPT AV APAQ E K - S L GNILQAK P TSSP A KG PPQ KAGPVAVQVKAEK P MDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARP AV SRST E S f A L PPDQPER P PQPQ A PP PPQ PQPQPPPPPQPQP P PPPPPRPQPPLAPTTDPAGAGEP 2955
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 57164979 628 TA A QAK P A L -------- KI P QTKACPKKTNTT A S A KVA P VRV G TQAP R KAGT A T S P A 676
Cdd:PHA03247 2956 SG A VPQ P W L galvpgrv AV P RFRVPQPAPSRE A P A SST P PLT G HSLS R VSSW A S S L A 3012
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
1.85e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|..
gi 57164979 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
Name
Accession
Description
Interval
E-value
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
387-904
7.52e-75
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 255.77
E-value: 7.52e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 387 A PA P PGK T GPA VAK A Q AGK R EEDS Q SSSEE S ------ DSEEEA P A QAKPSGK A PQVRAASAPAKESPRKGA A P A PP R KTG 460
Cdd:pfam03546 1 T PA T PGK A GPA ATQ A K AGK P EEDS E SSSEE E sdseee TPAAKT P L QAKPSGK T PQVRAASAPAKESPRKGA P P V PP G KTG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 461 PAAAQ V Q V GK Q EEDS R SSSEESDSD R E AL AA M ---- NA AQVKPLGK SP QV K PAST M G M GP L GKGA G P V PPGK V G P A T P SA 536
Cdd:pfam03546 81 PAAAQ A Q A GK P EEDS E SSSEESDSD G E TP AA A tltt SP AQVKPLGK NS QV R PAST V G K GP S GKGA N P A PPGK A G S A A P LV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 537 QVGK weed S E SS SE E SS DS SD G E VPTAV A PA Q E K SL G N ILQ AK P T S S PAKG ---- PPQKAGPVA V QVKAE KPMDN SESSE 612
Cdd:pfam03546 161 QVGK ---- K E ED SE S SS EE SD S E GEAPP A AT Q A K PS G K ILQ VR P A S G PAKG aapa PPQKAGPVA T QVKAE RSKED SESSE 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 613 ESSDS ADSEE A P A AMTA A qa KPALK I PQTKA C P K K TN -- T TA SAKV A PVRVGT Q AP R KAGT A TSPA G - SSPAVA G G T QRP 689
Cdd:pfam03546 237 ESSDS EEEAP A A A TPAQ A -- KPALK T PQTKA S P R K GT pi T PT SAKV P PVRVGT P AP W KAGT V TSPA C a SSPAVA R G A QRP 314
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 690 a E DS SSS E E SDSE EE K T GL A VT VGQAKSVGKGLQ V KAAS V P V KG SL GQGTAPV L PGKTGP T V T QVKAE K QEDSESSEEES 769
Cdd:pfam03546 315 - E ED SSS S E ESES EE E T AP A AA VGQAKSVGKGLQ G KAAS A P T KG PS GQGTAPV P PGKTGP A V A QVKAE A QEDSESSEEES 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 770 DSEEAAA S PAQVK T S V K KT QAKANPA AAR A P SAKG TI SAPGKVV T AAAQAKQ R SP S KVKPP V R N PQNS TVLA RG P ASVP S 849
Cdd:pfam03546 394 DSEEAAA T PAQVK A S G K TP QAKANPA PTK A S SAKG AA SAPGKVV A AAAQAKQ G SP A KVKPP A R T PQNS AISV RG Q ASVP A 473
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 850 VGKAVATAAQAQ T GP EEDSG --- S SEE E SD S EE E A E TL AQ V KPSGKT H Q I RAA L APAK 904
Cdd:pfam03546 474 VGKAVATAAQAQ K GP VGGPQ eed S ESS E EE S DS E E E AP AQ A KPSGKT P Q V RAA S APAK 531
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
212-511
2.35e-09
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 60.86
E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 212 VEG KP SV K PA Q V KAS S -------- V S T K ES P A R KAA PAP G K V G D VT PQVKGGALPP A KR A KK PEE E S E SSEE GSES EE E A 283
Cdd:pfam03546 252 AQA KP AL K TP Q T KAS P rkgtpitp T S A K VP P V R VGT PAP W K A G T VT SPACASSPAV A RG A QR PEE D S S SSEE SESE EE T A 331
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 284 PA GTRS Q V K ASE K I LQ VR AASAP A KG TP G K G AT P A PPGK A G AVAS Q T KA GKP E EDSE S SS E ES S DSEEE TP aakal L Q A K 363
Cdd:pfam03546 332 PA AAVG Q A K SVG K G LQ GK AASAP T KG PS G Q G TA P V PPGK T G PAVA Q V KA EAQ E DSES S EE E SD S EEAAA TP ----- A Q V K 406
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 364 ASGKT S Q VG A AS AP A K E S PR KGAA P A p PGK TGP A V A K A QA G kreedsqssseesdseee A PA QA KP SGKA PQ VR A A S A pa 443
Cdd:pfam03546 407 ASGKT P Q AK A NP AP T K A S SA KGAA S A - PGK VVA A A A Q A KQ G ------------------ S PA KV KP PART PQ NS A I S V -- 465
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 444 kesp R KG A APAPPR K TGPA AAQ V Q V G KQEEDSRSS SE E S DSDREALAAM n A AQ V KP L GK S PQV KP AS T 511
Cdd:pfam03546 466 ---- R GQ A SVPAVG K AVAT AAQ A Q K G PVGGPQEED SE S S EEESDSEEEA - P AQ A KP S GK T PQV RA AS A 528
PHA03247
PHA03247 large tegument protein UL36; Provisional
157-535
3.14e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.40
E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 157 P RK S AE P S AN TTLVSETEEEGSVPAFGAAAK PG M VS AGQADSSSEDTSSS S DETDVEGKPSVK P AQVKAS S VSTKES P AR 236
Cdd:PHA03247 2627 P PP S PS P A AN EPDPHPPPTVPPPERPRDDPA PG R VS RPRRARRLGRAAQA S SPPQRPRRRAAR P TVGSLT S LADPPP P PP 2706
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 237 KAA PAP gkvgdv TPQ V KGGA LPP AKR A KKPEEESESSEEGSESEEEA PA GTRSQVKASEKILQVRAASAPAKGT P GK G AT 316
Cdd:PHA03247 2707 TPE PAP ------ HAL V SATP LPP GPA A ARQASPALPAAPAPPAVPAG PA TPGGPARPARPPTTAGPPAPAPPAA P AA G PP 2780
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 317 PAPPGK A G A VA S QTKAGK P EEDSESSSEESSDSEEETPAAK A LLQAKASGK TS QVGA A SA P AKE sprkga A P A P PGKT G P 396
Cdd:PHA03247 2781 RRLTRP A V A SL S ESRESL P SPWDPADPPAAVLAPAAALPPA A SPAGPLPPP TS AQPT A PP P PPG ------ P P P P SLPL G G 2854
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 397 A VA KAQAGK R EED S Q S SSEESDSEEEA P AQ --- AKPSGKAPQVR A ASAPAK E S P RKGA AP A PP RKTGPAAAQV Q vgkqe E 473
Cdd:PHA03247 2855 S VA PGGDVR R RPP S R S PAAKPAAPARP P VR rla RPAVSRSTESF A LPPDQP E R P PQPQ AP P PP QPQPQPPPPP Q ----- P 2929
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57164979 474 DSRSSSEESDSDRE A LAAMN A AQVK P L G KS PQ VK pastmg M G P L GK G AGP VP PGK V GPAT PS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPL A PTTDP A GAGE P S G AV PQ PW ------ L G A L VP G RVA VP RFR V PQPA PS 2985
PHA03247
PHA03247 large tegument protein UL36; Provisional
234-676
4.95e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 47.63
E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 234 P ARKA AP A P GKVGDVTPQVKGG A L P PAK R AKK P EEESESSEEGSESEEEA P AGTRSQVKASE kilqv RAAS A PAKGTPGK 313
Cdd:PHA03247 2569 P PPRP AP R P SEPAVTSRARRPD A P P QSA R PRA P VDDRGDPRGPAPPSPLP P DTHAPDPPPPS ----- PSPA A NEPDPHPP 2643
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 314 GAT P A P PGKAGA v ASQTKAGK P EEDSESSSEESSD S EEET P AAK A LLQAKA S GKTSQVGAASA P AK E SPRKGAAP A P P GK 393
Cdd:PHA03247 2644 PTV P P P ERPRDD - PAPGRVSR P RRARRLGRAAQAS S PPQR P RRR A ARPTVG S LTSLADPPPPP P TP E PAPHALVS A T P LP 2722
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 394 T GPA V A KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA A S AP akes P RKG AA PA P P R K T G PA A A QVQVGKQEE 473
Cdd:PHA03247 2723 P GPA A A RQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP A P AP ---- P AAP AA GP P R R L T R PA V A SLSESRESL 2798
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 474 D S RSSSEESDSDRE A L AA MNAAQVK P L G KS P qvk P ASTMGMGPLGKGA GP V PP ----- G K V G P ATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 P S PWDPADPPAAVL A P AA ALPPAAS P A G PL P --- P PTSAQPTAPPPPP GP P PP slplg G S V A P GGDVRRRPPSRSPAAKP 2875
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 549 SEESSDSSDGEVPT AV APAQ E K - S L GNILQAK P TSSP A KG PPQ KAGPVAVQVKAEK P MDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARP AV SRST E S f A L PPDQPER P PQPQ A PP PPQ PQPQPPPPPQPQP P PPPPPRPQPPLAPTTDPAGAGEP 2955
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 57164979 628 TA A QAK P A L -------- KI P QTKACPKKTNTT A S A KVA P VRV G TQAP R KAGT A T S P A 676
Cdd:PHA03247 2956 SG A VPQ P W L galvpgrv AV P RFRVPQPAPSRE A P A SST P PLT G HSLS R VSSW A S S L A 3012
Treacle
pfam03546 Treacher Collins syndrome protein Treacle;
883-926
9.43e-05
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain]
Cd Length: 531
Bit Score: 46.22
E-value: 9.43e-05
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 57164979 883 T LA Q V KPSGKT H Q I RAA L APAKESPRKGA A P T PPGKTGP S AAQA 926
Cdd:pfam03546 43 T PL Q A KPSGKT P Q V RAA S APAKESPRKGA P P V PPGKTGP A AAQA 86
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
385-467
6.76e-04
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 43.73
E-value: 6.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 385 G AAPAPPGKTGP A V A K A Q A GKREEDSQSSSEESDSEEEAP A Q A KPSGKA P QVR AA S A P A KES P RKG AA P A P P RKT ----- 459
Cdd:PRK12270 37 G PGSTAAPTAAA A A A A A A A SAPAAAPAAKAPAAPAPAPPA A A A PAAPPK P AAA AA A A A A PAA P PAA AA A A A P AAA avede 116
90
....*....|...
gi 57164979 460 ----- G P AAA QVQ 467
Cdd:PRK12270 117 vtplr G A AAA VAK 129
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
234-499
8.79e-04
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 43.30
E-value: 8.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 234 PA RKAAP APG kv G D V TPQ V K G GALP P AK RA kkpeeesesse EGSESEEEA PA G T RSQVK A SEKILQVR AA S A P A KGTPGK 313
Cdd:PRK07003 360 PA VTGGG APG -- G G V PAR V A G AVPA P GA RA ----------- AAAVGASAV PA V T AVTGA A GAALAPKA AA A A A A TRAEAP 426
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 314 G A T PAPP GK A GAVASQTKAGK P EEDSESSSEESSDSEE E TP A AKALLQAK AS GKT S QVGAAS A PAKESPRKGAAP A P P GK 393
Cdd:PRK07003 427 P A A PAPP AT A DRGDDAADGDA P VPAKANARASADSRCD E RD A QPPADSGS AS APA S DAPPDA A FEPAPRAAAPSA A T P AA 506
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 394 TGP A V A K A Q A GKREEDSQSSSEESDSEEEA PA Q A K P SGK A PQVR AA --------------- S A P A KESPRKG AAPA PPR K 458
Cdd:PRK07003 507 VPD A R A P A A A SREDAPAAAAPPAPEARPPT PA A A A P AAR A GGAA AA ldvlrnagmrvssdr G A R A AAAAKPA AAPA AAP K 586
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 57164979 459 TGPAAAQ VQV GKQEEDSRSSSEESDSDRE A LA A MNAAQVK P 499
Cdd:PRK07003 587 PAAPRVA VQV PTPRARAATGDAPPNGAAR A EQ A AESRGAP P 627
LisH
smart00667 Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
6-37
1.85e-03
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913
Cd Length: 34
Bit Score: 36.64
E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|..
gi 57164979 6 K R R EL LP LI YHH LLR A GY VRA A REVKEQ SG QK 37
Cdd:smart00667 2 S R S EL NR LI LEY LLR N GY EET A ETLQKE SG LS 33
PHA03247
PHA03247 large tegument protein UL36; Provisional
240-675
3.10e-03
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 41.85
E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 240 P A P GKVGDVT P QVKGGAL PP AKR A KK P E E ESES S EEGSESEEEAP A GT R SQ V KASE kil QV R AASA P AKGT P GKG A TPA P 319
Cdd:PHA03247 2551 P P P PLPPAAP P AAPDRSV PP PRP A PR P S E PAVT S RARRPDAPPQS A RP R AP V DDRG --- DP R GPAP P SPLP P DTH A PDP P 2627
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 320 P GKAGAV A SQTKAGK P EEDSESSSEESS dseeet PA AKALLQAKASGKTSQVGA AS A P A k ES PR KG AA PAPP G KTGPAVA 399
Cdd:PHA03247 2628 P PSPSPA A NEPDPHP P PTVPPPERPRDD ------ PA PGRVSRPRRARRLGRAAQ AS S P P - QR PR RR AA RPTV G SLTSLAD 2700
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 400 KAQAGKRE E DSQSSSEESDSEEEA PA Q A KPSGK A PQVRA A SAPAKES P RKGAA PA - P P R KTGP A AAQVQVGKQEEDSRSS 478
Cdd:PHA03247 2701 PPPPPPTP E PAPHALVSATPLPPG PA A A RQASP A LPAAP A PPAVPAG P ATPGG PA r P A R PPTT A GPPAPAPPAAPAAGPP 2780
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 479 SEESDSDREA L AAMNAAQVK P LGKSPQVKPAS tmgmgplgk GAGPVP P GKVG PA T P SA qvgkwee DSE S SSEESSDSSD G 558
Cdd:PHA03247 2781 RRLTRPAVAS L SESRESLPS P WDPADPPAAVL --------- APAAAL P PAAS PA G P LP ------- PPT S AQPTAPPPPP G 2844
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 559 EV P TAVAPAQEKSL G NILQAK P T S - SPA KG P PQK A G P VAVQVKAEKPMDNS ES SEESS D SADSEEA P A A MTAA Q AK P ALK 637
Cdd:PHA03247 2845 PP P PSLPLGGSVAP G GDVRRR P P S r SPA AK P AAP A R P PVRRLARPAVSRST ES FALPP D QPERPPQ P Q A PPPP Q PQ P QPP 2924
410 420 430
....*....|....*....|....*....|....*...
gi 57164979 638 I P QTKAC P KKTNTTASAKV AP VRVGTQ A PRKA G TATS P 675
Cdd:PHA03247 2925 P P PQPQP P PPPPPRPQPPL AP TTDPAG A GEPS G AVPQ P 2962
kgd
PRK12270 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
378-465
4.75e-03
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain]
Cd Length: 1228
Bit Score: 41.03
E-value: 4.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 378 A KES P RKG AAP APPGKTGP A V A K A Q A gkreedsqssseesd SEEE A P A Q A K P SGKA P QVR A AS AP A K ESPRKG AA P AP PR 457
Cdd:PRK12270 34 A DYG P GST AAP TAAAAAAA A A A S A P A --------------- AAPA A K A P A A P APAP P AAA A PA AP P K PAAAAA AA A AP AA 98
....*...
gi 57164979 458 KTGP AAA Q 465
Cdd:PRK12270 99 PPAA AAA A 106
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
214-463
5.11e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 40.60
E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 214 G K P SVKPAQ V K A SSVSTKESPARK A A PA PG kvgdvt PQVKGGALPP A KR A KKPEEESESSEEGSESEEE A P A GTRSQVKA 293
Cdd:PRK07003 371 G V P ARVAGA V P A PGARAAAAVGAS A V PA VT ------ AVTGAAGAAL A PK A AAAAAATRAEAPPAAPAPP A T A DRGDDAAD 444
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 294 SEKILQVR A ASAPAKGTPGKGATPA PP GKA G AVASQTKAGK P EEDS E SSSEESSD S EEETP A AKALLQAK A SGKTSQVG A 373
Cdd:PRK07003 445 GDAPVPAK A NARASADSRCDERDAQ PP ADS G SASAPASDAP P DAAF E PAPRAAAP S AATPA A VPDARAPA A ASREDAPA A 524
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 374 A SA PA K E S - P RKG AA P AP PGKT G P A V A K ---- AQ AG K R EEDSQSSSEESDSEEE A PAQ A K P SGK AP Q V RA ------ A S A P 442
Cdd:PRK07003 525 A AP PA P E A r P PTP AA A AP AARA G G A A A A ldvl RN AG M R VSSDRGARAAAAAKPA A APA A A P KPA AP R V AV qvptpr A R A A 604
250 260
....*....|....*....|.
gi 57164979 443 AKES P RK GAA P A PPRKTGPA A 463
Cdd:PRK07003 605 TGDA P PN GAA R A EQAAESRG A 625
PRK07764
PRK07764 DNA polymerase III subunits gamma and tau; Validated
177-465
8.96e-03
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain]
Cd Length: 824
Bit Score: 39.97
E-value: 8.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 177 GSV PA FG A AAKPGMVS A GQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSV S TKESPARKA AP A P GKVGDVTP Q VKGGA 256
Cdd:PRK07764 391 AGA PA AA A PSAAAAAP A AAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP S PAGNAPAGG AP S P PPAAAPSA Q PAPAP 470
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 257 LPPAKRAKK P EEESESSEEGSESEEEAP A GTRSQ ------------------- V K A S E K ILQVRAAS A PAK G -------- 309
Cdd:PRK07764 471 AAAPEPTAA P APAPPAAPAPAAAPAAPA A PAAPA gaddaatlrerwpeilaav P K R S R K TWAILLPE A TVL G vrgdtlvl 550
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 310 --- T P G KGATP A P PG K A G ----------------- AV ASQTKAGKPE E DSESSSEESSDS E EET PAA K A LLQ A K A SGKTS 369
Cdd:PRK07764 551 gfs T G G LARRF A S PG N A E vlvtalaeelggdwqve AV VGPAPGAAGG E GPPAPASSGPPE E AAR PAA P A APA A P A APAPA 630
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 370 QVG AA S A P A KES P RK G A A PAPPGKTGP AV AK A QA G KREEDSQSSSEESDSEEE APA Q A K P SGK A PQVR A AS APA KESPRK 449
Cdd:PRK07764 631 GAA AA P A E A SAA P AP G V A APEHHPKHV AV PD A SD G GDGWPAKAGGAAPAAPPP APA P A A P AAP A GAAP A QP APA PAATPP 710
330
....*....|....*.
gi 57164979 450 GAAPAP P RKTG P A AAQ 465
Cdd:PRK07764 711 AGQADD P AAQP P Q AAQ 726
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
