NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|57164303|ref|NP_001009273|]
View 

aquaporin-5 [Ovis aries]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 1.74e-77

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 234.13  E-value: 1.74e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303     4 EVCSAAFLKAVFAEFLATLIFVFFGLGSALKWPSAMPS-----VLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    79 GNQISLLRAVFYLVAQLVGAIAGAAILYGLAPYNARSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57164303   159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSaHWVFWVGPIVGAATAAIIY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDD-HWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 1.74e-77

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 234.13  E-value: 1.74e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303     4 EVCSAAFLKAVFAEFLATLIFVFFGLGSALKWPSAMPS-----VLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    79 GNQISLLRAVFYLVAQLVGAIAGAAILYGLAPYNARSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57164303   159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSaHWVFWVGPIVGAATAAIIY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDD-HWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-224 9.74e-69

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 211.73  E-value: 9.74e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  12 KAVFAEFLATLIFVFFGLGSALKW---PSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRAV 88
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  89 FYLVAQLVGAIAGAAILYGL---------APYNARSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTD-SRRTSPV 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLyyglyleflGANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164303 159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFS--SAHWVFWVGPIVGAATAAIIYFYL 224
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-221 1.51e-62

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 195.60  E-value: 1.51e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    16 AEFLATLIFVFFGLGSAL-------KWPSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRAV 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    89 FYLVAQLVGAIAGAAILYGLAPYNAR-SNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPgNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 57164303   167 LSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFS-SAHWVFWVGPIVGAATAAIIY 221
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-225 1.11e-54

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 176.09  E-value: 1.11e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  10 FLKAVFAEFLATLIFVFFGLGSA--LKWPSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRA 87
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  88 VFYLVAQLVGAIAGAAILYGLAPYNARSNLAVNALN--------NNTTAGQAVVAEMILTFQLALCVFSSTDSRRTsPVG 159
Cdd:COG0580  82 LPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57164303 160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFS-----SAHWVFWVGPIVGAATAAIIYFYLL 225
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwGYLWVPIVAPILGAALAALLYRALF 231
PRK05420 PRK05420
aquaporin Z; Provisional
 11-225 6.81e-41

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 140.49  E-value: 6.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   11 LKAVFAEFLATLIFVFFGLGSALkWPSAMPSV----LQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   87 AVFYLVAQLVGAIAGAAILY----GLAPYNARSNLAVNALNNNTTAGQ-----AVVAEMILTFQLALCVFSSTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYliasGKAGFDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 57164303  158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSAH-WVFWVGPIVGAATAAIIYFYLL 225
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEQlWLFWVAPIVGAIIGGLIYRLLL 227
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 1.74e-77

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 234.13  E-value: 1.74e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303     4 EVCSAAFLKAVFAEFLATLIFVFFGLGSALKWPSAMPS-----VLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLV 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSlavsgLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    79 GNQISLLRAVFYLVAQLVGAIAGAAILYGLAPYNARSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 57164303   159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSaHWVFWVGPIVGAATAAIIY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDD-HWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-224 9.74e-69

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 211.73  E-value: 9.74e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  12 KAVFAEFLATLIFVFFGLGSALKW---PSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRAV 88
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  89 FYLVAQLVGAIAGAAILYGL---------APYNARSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTD-SRRTSPV 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLyyglyleflGANNIVAGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164303 159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFS--SAHWVFWVGPIVGAATAAIIYFYL 224
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-221 1.51e-62

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 195.60  E-value: 1.51e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    16 AEFLATLIFVFFGLGSAL-------KWPSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRAV 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    89 FYLVAQLVGAIAGAAILYGLAPYNAR-SNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPgNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 57164303   167 LSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFS-SAHWVFWVGPIVGAATAAIIY 221
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-225 1.11e-54

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 176.09  E-value: 1.11e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  10 FLKAVFAEFLATLIFVFFGLGSA--LKWPSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRA 87
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  88 VFYLVAQLVGAIAGAAILYGLAPYNARSNLAVNALN--------NNTTAGQAVVAEMILTFQLALCVFSSTDSRRTsPVG 159
Cdd:COG0580  82 LPYIIAQLLGAFLGAALVYLIYGGHFDATEDGGAKLgvfatspaIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 57164303 160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFS-----SAHWVFWVGPIVGAATAAIIYFYLL 225
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwGYLWVPIVAPILGAALAALLYRALF 231
PRK05420 PRK05420
aquaporin Z; Provisional
 11-225 6.81e-41

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 140.49  E-value: 6.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   11 LKAVFAEFLATLIFVFFGLGSALkWPSAMPSV----LQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   87 AVFYLVAQLVGAIAGAAILY----GLAPYNARSNLAVNALNNNTTAGQ-----AVVAEMILTFQLALCVFSSTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYliasGKAGFDLAGSGFASNGYGEHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 57164303  158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSAH-WVFWVGPIVGAATAAIIYFYLL 225
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEQlWLFWVAPIVGAIIGGLIYRLLL 227
PLN00166 PLN00166
aquaporin TIP2; Provisional
 7-221 7.03e-35

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 125.82  E-value: 7.03e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    7 SAAFLKAVFAEFLATLIFVFFGLGSALKWPSAM-------PSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVG 79
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFAKLTsdaaldpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   80 NQISLLRAVFYLVAQLVGAIAGAAILYGLApyNARSNLAVNALNNNtTAGQAVVAEMILTFQLALCVFSSTDSRRTSPVG 159
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVT--NGESVPTHGVAAGL-GAIEGVVMEIVVTFALVYTVYATAADPKKGSLG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 57164303  160 SPA-LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSaHWVFWVGPIVGAATAAIIY 221
Cdd:PLN00166 171 TIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQ-IWIYWVGPLVGGALAGLIY 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-229 7.14e-35

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 125.67  E-value: 7.14e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   11 LKAVFAEFLATLIFVFFGLGSALKWP------SAMPSVL-QISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQIS 83
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSGMAFNkltdngSTTPAGLvAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   84 LLRAVFYLVAQLVGAIAgAAILYGLAPYNArsNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPVGSPA- 162
Cdd:PLN00027 100 LLRGILYWIAQLLGSVV-ACLLLKFSTGGL--ETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGIIAp 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57164303  163 LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVImSRFSSAHWVFWVGPIVGAATAAIIYFYLLFPHS 229
Cdd:PLN00027 177 IAIGFIVGANILAGGAFDGASMNPAVSFGPAVV-SWTWTNHWVYWAGPLIGGGIAGLVYELIFIGST 242
PLN00167 PLN00167
aquaporin TIP5; Provisional
 3-227 2.08e-31

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 116.54  E-value: 2.08e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    3 KEVCSAAFLKAVFAEFLATLIFVFFGLGSALKWPSAMP-------SVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLA 75
Cdd:PLN00167  14 QQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPdaasdpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   76 LLVGNQISLLRAVFYLVAQLVGAIAGAAILyglapynaRSNLAVNALNNNTTAGQ-----AVVAEMILTFQLALCVFSST 150
Cdd:PLN00167  94 MAVGGHISVPTAMFYWISQMLASVMACLFL--------KVTTVGQHVPTYKIAEEmtgfgASVLEGVLTFGLVYTVYAAG 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 57164303  151 DSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSaHWVFWVGPIVGAATAAIIYFYLLFP 227
Cdd:PLN00167 166 DPRRGLLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKN-QAVYWVGPLLGGAVAGLLYDNVVFP 241
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 16-227 1.10e-23

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 97.12  E-value: 1.10e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   16 AEFLATLIFVFFGLGSALKWPSAMPSVLQISLAFGLAIG-TMA--QALGpVSGGHMNPAITLALLVGNQISLLRAVFYLV 92
Cdd:PTZ00016  55 AEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGvTFGllVSAG-ISGGHLNPAVTLGNAVFGKFPWKKLPGYFV 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   93 AQLVGAIAGAAILYGL--------------APYNARSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFSSTDSRRTSPV 158
Cdd:PTZ00016 134 AQLLGAFVGAACVYGLyygffkdhgipelpWETMANGFAGVFATYPREGNFYAIFSELILTAILLLVILAITDPNNCPAF 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303  159 GSPALSIGLSVTlghLVGIYF---TGCSMNPARSFGPAVIMS------RFSSAHWVFW---VGPIVGAATAAIIYFYLLF 226
Cdd:PTZ00016 214 NYLPVAVGLLVF---VIGISFggnTGYALNPARDLGPRLFSAilwgseVFTKDNYYFWvplVAPFVGAVLGMFLYDKFIP 290


                 .
gi 57164303  227 P 227
Cdd:PTZ00016 291 P 291
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 1-226 1.95e-22

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 93.44  E-value: 1.95e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    1 MKKEVCSA----AFLKAVFAEFLATLIFVFFGLGSALKWPSAMPSVL--QISLAFGLAIGTMAQALGPVSGGHMNPAITL 74
Cdd:PLN00182  28 IETAICTSpsivCLTQKLIAEMIGTYFIIFSGCGVVVVNVLYGGTITfpGICVTWGLIVMVMIYSTGHISGAHFNPAVTV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   75 ALLVGNQISLLRAVFYLVAQLVGAIAGA---AILYGLAPynarsnLAVNALNNNTTAGQAVVAEMILTFQLALCVFS-ST 150
Cdd:PLN00182 108 TFAIFRRFPWYQVPLYIGAQLTGSLLASltlRLMFNVTP------EAFFGTTPTDSSGQALVAEIIISFLLMFVISGvAT 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 57164303  151 DSRRTSPVGspALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSAhWVFWVGPIVGAATAAIIYFYLLF 226
Cdd:PLN00182 182 DSRAVGELA--GIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGI-WVYIVGPFVGIIAGGFVYNLIRF 254
PLN00184 PLN00184
aquaporin NIP1; Provisional
 7-221 2.46e-22

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 93.55  E-value: 2.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303    7 SAAFLKAVFAEFLATLIFVFFGLGSAL--KWPSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISL 84
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASVVvnMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   85 LRAVFYLVAQLVGAIAGAA---ILYGLaPYNARSNLAVNALNNNTTAG--QAVVAEMILTFQLALCVFS-STDSRRTSPV 158
Cdd:PLN00184 130 KQVPAYVISQVIGSTLAAAtlrLLFGL-DHDVCSGKHDVFIGSSPVGSdlQAFVMEFIVTFYLMFIISGvATDNRAIGEL 208

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 57164303  159 GspALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSAhWVFWVGPIVGAATAAIIY 221
Cdd:PLN00184 209 A--GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGI-WIYIVAPTLGAIAGAWVY 268
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 11-235 4.62e-18

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 81.44  E-value: 4.62e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   11 LKAVFAEFLATLIFVF--FGLGSALKWPSAMPSVLQISLAFGLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRAV 88
Cdd:PLN00183  45 ARMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVP 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   89 FYLVAQLVGAIAgaailyglAPYNARSNLAVNALNNNTTAGQAVVA----EMILTFQLA-LCVFSSTDSRRTSPVGspAL 163
Cdd:PLN00183 125 LYITAQTVGSVL--------ATYVGVSVYGVKADLMTTKPAQGCSSafwvEFIATFIVMfLAASLTSQPQSLGHLS--GF 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57164303  164 SIGLSVTLGHLVGIYFTGCSMNPARSFGPAVIMSRFSSAhWVFWVGPIVGAATAAIIYfyllfpHSLSLSDR 235
Cdd:PLN00183 195 VIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDI-WIYITAPTIGAVAGALMF------HLLRLRTQ 259
PLN00026 PLN00026
aquaporin NIP; Provisional
 16-221 5.75e-18

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 81.45  E-value: 5.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   16 AEFLATLIFVFFGLGSALKWPSAMPSVLQISLAF--GLAIGTMAQALGPVSGGHMNPAITLALLVGNQISLLRAVFYLVA 93
Cdd:PLN00026  76 AEFVGTFILIFAATAGPIVNQKYDGAETLIGNAAcaGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAA 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164303   94 QLVGAIAGAAILYGLApynaRSNLAVNALNNNTTAGQAVVAEMILTFQLALCVFS-STDSRrtsPVGSPA-LSIGLSVTL 171
Cdd:PLN00026 156 QVSASICASFALKGVF----HPFMSGGVTVPSVSTGQAFALEFIITFNLLFVVTAvATDTR---AVGELAgIAVGATVML 228

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 57164303  172 GHLVGIYFTGCSMNPARSFGPAVIMSRFsSAHWVFWVGPIVGAATAAIIY 221
Cdd:PLN00026 229 NILVAGPSTGGSMNPVRTLGPAVAAGNY-RAIWIYLVAPTLGALAGAGTY 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH