NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|56971431|gb|AAH88378|]
View 

LRP10 protein, partial [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 63-97 2.11e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 2.11e-12
                        10        20        30
                ....*....|....*....|....*....|....*
gi 56971431  63 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 97
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
PRK04654 super family cl31366
sec-independent translocase; Provisional
 237-339 2.73e-04

sec-independent translocase; Provisional


The actual alignment was detected with superfamily member PRK04654:

Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 41.72  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971431  237 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 304
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 56971431  305 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 339
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1-17 7.46e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 33.72  E-value: 7.46e-03
                        10
                ....*....|....*..
gi 56971431   1 RCDGSWDCADGTDEEDC 17
Cdd:cd00112  19 VCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 63-97 2.11e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 2.11e-12
                        10        20        30
                ....*....|....*....|....*....|....*
gi 56971431  63 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 97
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 63-94 7.80e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 7.80e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 56971431     63 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 94
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
63-97 4.47e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 4.47e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 56971431    63 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 97
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
PRK04654 PRK04654
sec-independent translocase; Provisional
 237-339 2.73e-04

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 41.72  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971431  237 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 304
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 56971431  305 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 339
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1-17 7.46e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 33.72  E-value: 7.46e-03
                        10
                ....*....|....*..
gi 56971431   1 RCDGSWDCADGTDEEDC 17
Cdd:cd00112  19 VCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1-17 7.93e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 33.76  E-value: 7.93e-03
                          10
                  ....*....|....*..
gi 56971431     1 RCDGSWDCADGTDEEDC 17
Cdd:pfam00057  21 VCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 63-97 2.11e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 2.11e-12
                        10        20        30
                ....*....|....*....|....*....|....*
gi 56971431  63 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 97
Cdd:cd00112   1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 63-94 7.80e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 7.80e-11
                           10        20        30
                   ....*....|....*....|....*....|..
gi 56971431     63 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 94
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
63-97 4.47e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.18  E-value: 4.47e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 56971431    63 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 97
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
PRK04654 PRK04654
sec-independent translocase; Provisional
 237-339 2.73e-04

sec-independent translocase; Provisional


Pssm-ID: 135173 [Multi-domain]  Cd Length: 214  Bit Score: 41.72  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971431  237 ARASEARSQVTPSAAPLE-ALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLP----SASTSPAP--TTVPE-----APGP 304
Cdd:PRK04654  96 SRDIDIRTSATPVATPLElAHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPviaqAQPIAPAPhqTLVPAphdtiVPAP 175

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 56971431  305 ----LPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSP 339
Cdd:PRK04654 176 haahLPSAPATPVSVAPVDAGTSASPTPSEPTKIQEKQP 214
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 235-345 5.47e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.93  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56971431  235 TPARASEArsqvTPSAAPLEALDGGTGPAREGGAVggqdgeQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSL 314
Cdd:PRK14951 380 TPARPEAA----APAAAPVAQAAAAPAPAAAPAAA------ASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAP 449

                         90       100       110
                 ....*....|....*....|....*....|.
gi 56971431  315 LSGVVQALRGRLLPSLGPPGPTRSPPGPHTA 345
Cdd:PRK14951 450 APPAQAAPETVAIPVRVAPEPAVASAAPAPA 480
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 1-17 7.46e-03

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 33.72  E-value: 7.46e-03
                        10
                ....*....|....*..
gi 56971431   1 RCDGSWDCADGTDEEDC 17
Cdd:cd00112  19 VCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
1-17 7.93e-03

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 33.76  E-value: 7.93e-03
                          10
                  ....*....|....*..
gi 56971431     1 RCDGSWDCADGTDEEDC 17
Cdd:pfam00057  21 VCDGDPDCGDGSDEENC 37
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 233-304 8.56e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.43  E-value: 8.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 56971431  233 TNTPARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGP 304
Cdd:PRK07764 428 APQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH