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Conserved domains on  [gi|569011415|ref|XP_006528637|]
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pramel3 family member isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
216-411 1.44e-03

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 216 DLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSkiacrslngrtfRNFITQL----SRMNHLKELSLSSFCLTDhLENV 291
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLS------------NNQLTDLpeelGNLTNLKELDLSNNQITD-LPEP 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 292 LRVLSAdLEFLYLpfcglSYSDFKFLSEC-SQVSHLKLLNVNNNPIywEDCEPFYYLlqnvsSTLQHLKICYCFLTDsti 370
Cdd:COG4886  201 LGNLTN-LEELDL-----SGNQLTDLPEPlANLTNLETLDLSNNQL--TDLPELGNL-----TNLEELDLSNNQLTD--- 264

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 569011415 371 svlIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKEL 411
Cdd:COG4886  265 ---LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-411 1.44e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 216 DLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSkiacrslngrtfRNFITQL----SRMNHLKELSLSSFCLTDhLENV 291
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLS------------NNQLTDLpeelGNLTNLKELDLSNNQITD-LPEP 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 292 LRVLSAdLEFLYLpfcglSYSDFKFLSEC-SQVSHLKLLNVNNNPIywEDCEPFYYLlqnvsSTLQHLKICYCFLTDsti 370
Cdd:COG4886  201 LGNLTN-LEELDL-----SGNQLTDLPEPlANLTNLETLDLSNNQL--TDLPELGNL-----TNLEELDLSNNQLTD--- 264

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 569011415 371 svlIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKEL 411
Cdd:COG4886  265 ---LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
216-411 1.44e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 216 DLKCVDHLAVDESPLTEVTKLLSHTIQLDSLSLSkiacrslngrtfRNFITQL----SRMNHLKELSLSSFCLTDhLENV 291
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLS------------NNQLTDLpeelGNLTNLKELDLSNNQITD-LPEP 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 292 LRVLSAdLEFLYLpfcglSYSDFKFLSEC-SQVSHLKLLNVNNNPIywEDCEPFYYLlqnvsSTLQHLKICYCFLTDsti 370
Cdd:COG4886  201 LGNLTN-LEELDL-----SGNQLTDLPEPlANLTNLETLDLSNNQL--TDLPELGNL-----TNLEELDLSNNQLTD--- 264

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 569011415 371 svlIPALTRCSQLRVLHFYSNQITMGMLMRILELLTPLKEL 411
Cdd:COG4886  265 ---LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLL 302
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
145-394 3.24e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 3.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 145 ESLSSSKSEAQPSRLPMELIVDISLDGTLRERNFFALLQNKVEQSLGSLHLCCRDLQINNLCECRHALSHLDLKCVDhla 224
Cdd:COG4886   43 LSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLD--- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 225 VDESPLTEVTKLLSHTIQLDSLSLSkiacrslnGRTFRNFITQLSRMNHLKELSLSSFCLTDhLENVLRVLSAdLEFLYL 304
Cdd:COG4886  120 LSGNQLTDLPEELANLTNLKELDLS--------NNQLTDLPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTN-LKELDL 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569011415 305 pfcglSYSDFKFLSEC-SQVSHLKLLNVNNNPIywedcEPFYYLLQNVSStLQHLKICYCFLTDstisvlIPALTRCSQL 383
Cdd:COG4886  190 -----SNNQITDLPEPlGNLTNLEELDLSGNQL-----TDLPEPLANLTN-LETLDLSNNQLTD------LPELGNLTNL 252

                        250
                 ....*....|.
gi 569011415 384 RVLHFYSNQIT 394
Cdd:COG4886  253 EELDLSNNQLT 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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