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Conserved domains on  [gi|568982477|ref|XP_006516976|]
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lysine-specific histone demethylase 1B isoform X1 [Mus musculus]

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393
PubMed:  23266887|23260659

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 315-831 4.48e-94

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.08  E-value: 4.48e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 467
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 468 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 544
Cdd:PLN02328 314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02328 390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 625 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 704
Cdd:PLN02328 469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 705 GLFAVFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 781
Cdd:PLN02328 545 GEFFLFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568982477 782 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:PLN02328 625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 6.06e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.61  E-value: 6.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568982477  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 315-831 4.48e-94

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.08  E-value: 4.48e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 467
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 468 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 544
Cdd:PLN02328 314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02328 390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 625 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 704
Cdd:PLN02328 469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 705 GLFAVFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 781
Cdd:PLN02328 545 GEFFLFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568982477 782 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:PLN02328 625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 412-831 5.63e-73

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.86  E-value: 5.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  412 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQLGI----SMRKLGERCDLIQEGGRI 487
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  488 TDPTVDkRMDFHFNALLDVVSEW----------------RKDKTLLQDVPLGEKIEEIYR-AFVKESGIQFSELEGQVLQ 550
Cdd:pfam01593  86 YPGDFR-RVPAGWEGLLEFGRLLsipeklrlglaalasdALDEFDLDDFSLAESLLFLGRrGPGDVEVWDRLIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  551 FHLSNLEYACGSSLHQVSArSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTD 627
Cdd:pfam01593 165 LPFASGAFAGDPSELSAGL-ALPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  628 GMGHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLF 707
Cdd:pfam01593 244 GEVIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  708 AVFYDMDSQ----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFV 782
Cdd:pfam01593 318 FSWLTFPNRappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 568982477  783 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:pfam01593 397 QYGPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
412-833 1.34e-71

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 242.13  E-value: 1.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 412 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQIVNGcinNPVALM--CEQLGISMRKL--GERCDLIQEGGR 486
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFpnENGNALLYLGGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 487 ITdptvdkRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIY-----RAFVKESGIQFSelegqVLQFHLSNLEYAC 560
Cdd:COG1231  101 RV------RAGEIAADLRGVAELLAKlLRALAAALDPWAHPAAELdreslAEWLRRNGASPS-----ARRLLGLLGAGEY 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 561 GSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLV 638
Cdd:COG1231  170 GADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIV 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 639 TVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFYDMDSQ 716
Cdd:COG1231  250 TVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSNGP 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 717 QQS--VLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDII 794
Cdd:COG1231  320 DGGagVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPAL 398

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 568982477 795 AeEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 833
Cdd:COG1231  399 A-EPDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 6.06e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.61  E-value: 6.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568982477  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 315-831 4.48e-94

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 313.08  E-value: 4.48e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQL 467
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQL 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 468 GISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLLQDVPLGEKIEeiyrAFVKESGIQFSEL 544
Cdd:PLN02328 314 GLPLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQ 389

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02328 390 ERMLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVY 468

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 625 TTdGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQR 704
Cdd:PLN02328 469 AG-GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMR 544

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 705 GLFAVFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSF 781
Cdd:PLN02328 545 GEFFLFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSY 624

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568982477 782 VKTFGSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:PLN02328 625 VAVGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
PLN03000 PLN03000
amine oxidase
 320-832 5.99e-90

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 303.48  E-value: 5.99e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 320 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVltVAAGQHLLPKHYHNKSVL 399
Cdd:PLN03000 117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGI--AQAIKDKFPAQSSKSSVV 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 400 VVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK---SFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGE 476
Cdd:PLN03000 189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRD 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 477 RCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK---DKTLlqDVPLGEKIEeiyrAFVKESGIQFSELEGQVLQFHL 553
Cdd:PLN03000 269 KCPLYRVDGKPVDPDVDLKVEVAFNQLLDKASKLRQlmgDVSM--DVSLGAALE----TFRQVSGNDVATEEMGLFNWHL 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 554 SNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgHSA 633
Cdd:PLN03000 343 ANLEYANAGLVSKLSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEG 420

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 634 QKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDM 713
Cdd:PLN03000 421 DMVLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSY 497

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 714 DS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEA 790
Cdd:PLN03000 498 APvAGGPLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQGInvPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDD 577

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 568982477 791 YDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 832
Cdd:PLN03000 578 YDILAESVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02529 PLN02529
lysine-specific histone demethylase 1
 320-831 2.06e-88

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 296.03  E-value: 2.06e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 320 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLTVAAGQhlLPKHYHN 395
Cdd:PLN02529  93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 396 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK-SFKG--VVVGRGPQIVNGCINNPVALMCEQLGISMR 472
Cdd:PLN02529 161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSIPLH 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 473 KLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIYRAFvkesGIQFSELEGQVLQF 551
Cdd:PLN02529 241 KVRDNCPLYKPDGALVDKEIDSNIEFIFNKLLDKVTELRQiMGGFANDISLGSVLERLRQLY----GVARSTEERQLLDW 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 552 HLSNLEYACGSSLHQVSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgH 631
Cdd:PLN02529 317 HLANLEYANAGCLSDLSAAYWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-F 394

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 632 SAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFY 711
Cdd:PLN02529 395 QADMVLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFY 471

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 712 DMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELF--KEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSG 788
Cdd:PLN02529 472 GYHTvSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSG 551

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 568982477 789 EAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:PLN02529 552 SDYDILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
PLN02976 PLN02976
amine oxidase
 396-831 3.40e-77

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 274.05  E-value: 3.40e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  396 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGC--------INNPVALMCEQL 467
Cdd:PLN02976  694 KKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTDRSSLSVPVDLGASIITGVeadvaterRPDPSSLICAQL 773

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  468 GISMRKLGERCDL--IQEGGRITDpTVDKRMDFHFNALLD----VVSE-----------------------------WRK 512
Cdd:PLN02976  774 GLELTVLNSDCPLydVVTGEKVPA-DLDEALEAEYNSLLDdmvlLVAQkgehamkmsledgleyalkrrrmprpgvdIDE 852

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  513 DKTLLQDVPL--GEKIEEIYRAFVKESGIQF-SELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLT 589
Cdd:PLN02976  853 TELGNAADDLydSASTGVDGGHCEKESKEDVlSPLERRVMNWHFAHLEYGCAALLKEVSLPYWNQDDVYGGFGGAHCMIK 932

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  590 PGYSTIIEKLAEGLDIRLKSPVQSIDYTGDE----------VQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEK 659
Cdd:PLN02976  933 GGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKVSTSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDW 1012

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  660 KMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDMDSQQQS-VLMSVITGEAVASLRTMDD 738
Cdd:PLN02976 1013 KYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDLRGQCFMFWNVKKTVGApVLIALVVGKAAIDGQSMSS 1089

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  739 KQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVT 818
Cdd:PLN02976 1090 SDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYVAIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVG 1169

                         490
                  ....*....|...
gi 568982477  819 GAYLSGVREASKI 831
Cdd:PLN02976 1170 GAMMSGLREAVRI 1182
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 412-831 5.63e-73

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 245.86  E-value: 5.63e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  412 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQLGI----SMRKLGERCDLIQEGGRI 487
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  488 TDPTVDkRMDFHFNALLDVVSEW----------------RKDKTLLQDVPLGEKIEEIYR-AFVKESGIQFSELEGQVLQ 550
Cdd:pfam01593  86 YPGDFR-RVPAGWEGLLEFGRLLsipeklrlglaalasdALDEFDLDDFSLAESLLFLGRrGPGDVEVWDRLIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  551 FHLSNLEYACGSSLHQVSArSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTD 627
Cdd:pfam01593 165 LPFASGAFAGDPSELSAGL-ALPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTD 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  628 GMGHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLF 707
Cdd:pfam01593 244 GEVIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTA 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477  708 AVFYDMDSQ----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFV 782
Cdd:pfam01593 318 FSWLTFPNRappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 568982477  783 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:pfam01593 397 QYGPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
412-833 1.34e-71

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 242.13  E-value: 1.34e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 412 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQIVNGcinNPVALM--CEQLGISMRKL--GERCDLIQEGGR 486
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFpnENGNALLYLGGK 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 487 ITdptvdkRMDFHFNALLDVVSEWRK-DKTLLQDVPLGEKIEEIY-----RAFVKESGIQFSelegqVLQFHLSNLEYAC 560
Cdd:COG1231  101 RV------RAGEIAADLRGVAELLAKlLRALAAALDPWAHPAAELdreslAEWLRRNGASPS-----ARRLLGLLGAGEY 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 561 GSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLV 638
Cdd:COG1231  170 GADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIV 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 639 TVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFYDMDSQ 716
Cdd:COG1231  250 TVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSNGP 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 717 QQS--VLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDII 794
Cdd:COG1231  320 DGGagVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPAL 398

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 568982477 795 AeEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 833
Cdd:COG1231  399 A-EPDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
PLN02268 PLN02268
probable polyamine oxidase
 397-831 2.08e-62

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 216.86  E-value: 2.08e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 397 SVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFkGVVVGRGPQIVNG-CINNPVALMCEQLGISM-RKL 474
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLAPLIGRLGLPLyRTS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 475 G----------ERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTllQDVPLgekIEEIYRAFVKESGIQFSEL 544
Cdd:PLN02268  81 GdnsvlydhdlESYALFDMDGNQVPQELVTKVGETFERILEETEKVRDEHE--EDMSL---LQAISIVLERHPELRLEGL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 545 EGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAqfaGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVT 624
Cdd:PLN02268 156 AHEVLQWYLCRMEGWFAADADTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVKVT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 625 TTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSASQR 704
Cdd:PLN02268 233 VEDGTTFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSYGC 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 705 GLFAVFYdmDSQQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRWSTEPWIQMAYSFVKT 784
Cdd:PLN02268 309 SYFLNLH--KATGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLPDA--TEPVQYLVSRWGSDPNSLGCYSYDLV 384

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 568982477 785 FGSGEAYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:PLN02268 385 GKPHDLYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 397-831 1.17e-37

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 147.55  E-value: 1.17e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 397 SVLVVGAGPAGLAAARQLHNFGMK-VTVLEAKDRIGGRVwDDKSFKGVVVGRGP---QIVNGCINNPVALMCEQLGisMR 472
Cdd:PLN02676  28 SVIIVGAGMSGISAAKTLSEAGIEdILILEATDRIGGRM-RKANFAGVSVELGAnwvEGVGGPESNPIWELANKLK--LR 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 473 KLGERCDLI------QEGGRITDPTVDKRMDfhfnaLLDVVSEWrkdKTLLQDVPLGEKIEEIyrafvkeSGIQFSELEG 546
Cdd:PLN02676 105 TFYSDFDNLssniykQDGGLYPKKVVQKSMK-----VADASDEF---GENLSISLSAKKAVDI-------SILTAQRLFG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 547 Q--------VLQFHLSNLEYA---CGSSLHQVSARSwdhneFFAQFAGDHTLLTP--GYSTIIEKLAEG---------LD 604
Cdd:PLN02676 170 QvpktplemVIDYYNYDYEFAeppRVTSLKNTEPNP-----TFVDFGEDEYFVADprGYESLVYYLAEQflstksgkiTD 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 605 IRLK--SPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYR 682
Cdd:PLN02676 245 PRLKlnKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDWKIEAIYQFDMAVYTKIFLKFPYK 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 683 FWDSKvQGADFFGHvppSASQRGLFAVFYDMDSQQ--QSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeIPE 760
Cdd:PLN02676 325 FWPSG-PGTEFFLY---AHERRGYYPFWQHLENEYpgSNVLFVTVTDEESRRIEQQPDSETKAEIMEVLRKMFGPN-IPE 399

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568982477 761 PTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVrEASKI 831
Cdd:PLN02676 400 ATDILVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYVHGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 420-831 2.03e-32

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 133.03  E-value: 2.03e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 420 KVTVLEAKDRIGGRVwDDKSFKGVVVGRGPQIVNGCINNPV--------ALMCEQLGISMRKLGERCDLIQEGGRITDPT 491
Cdd:PLN02568  35 ELTVVEGGDRIGGRI-NTSEFGGERIEMGATWIHGIGGSPVykiaqeagSLESDEPWECMDGFPDRPKTVAEGGFEVDPS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 492 VDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIE----------------------EIYRAFVKE-------SGIQFS 542
Cdd:PLN02568 114 IVESISTLFRGLMDDAQGKLIEPSEVDEVDFVKLAAkaarvcesggggsvgsflrrglDAYWDSVSAdeqikgyGGWSRK 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 543 ELEGQVLQFHlSNLEyACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLD---IRLKSPVQSIDYTGD 619
Cdd:PLN02568 194 LLEEAIFTMH-ENTQ-RTYTSADDLSTLDLAAESEYRMFPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQDE 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 620 EVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQ----FNPPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGADFFg 695
Cdd:PLN02568 272 PVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFSPPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAKF- 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 696 hvpPSasqrgLFAVFYDMDSQQQ---------------------SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFK 754
Cdd:PLN02568 350 ---PF-----LQMAFHRSDSEARhdkipwwmrrtasicpihknsSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLK 421

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 755 EQEIPEP---------------------TKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGT------------ 801
Cdd:PLN02568 422 RRVAGLGsqshplcnggassndgsrwkfVKVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplq 501

                        490       500       510
                 ....*....|....*....|....*....|
gi 568982477 802 VFFAGEATNRHFPQTVTGAYLSGVREASKI 831
Cdd:PLN02568 502 LLFAGEATHRTHYSTTHGAYFSGLREANRL 531
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 412-769 7.61e-12

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 68.32  E-value: 7.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 412 RQLHNFGMKVTVLEAKDRIGGRVwddKSF--KGVVVGRGPQIVngCINNPVAL-MCEQLGIS--MRKLGERCDLIQEGGR 486
Cdd:COG1232   18 YRLAKAGHEVTVLEASDRVGGLI---RTVevDGFRIDRGPHSF--LTRDPEVLeLLRELGLGdeLVWPNTRKSYIYYGGK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 487 ITD-PTvdKRMDFHFNALLDVVSEWR-------KDKTLLQDVPLGEKI-----EEIYRAFVKE--SGIqFS----ELEGQ 547
Cdd:COG1232   93 LHPlPQ--GPLALLRSPLLSLAGKLRallellaPRRPPGEDESLAEFVrrrfgREVYERLVEPllEGV-YAgdpdELSAD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 548 -VLQFhLSNLEYACGSSLHQVSA--RSWDHNEFFAQFAGdhtlltpGYSTIIEKLAEGL---DIRLKSPVQSIDYTGDEV 621
Cdd:COG1232  170 wAFPR-LKRLELEHGSLIKGALAlrKGAKAGEVFGYLRG-------GLGTLVEALAEALeagEIRLGTRVTAIEREGGGW 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 622 QVTTTDGMGHSAQKVLVTVPLAILQRgAIQFNPPLSEKKMKAINSLGAGIiekIALQFPyrfwDSKVQGADFFGHVPPSA 701
Cdd:COG1232  242 RVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYASVAV---VALGFD----RPDLPPPDGFGWLVPRD 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568982477 702 SQRGLFAVFY------DMDSQQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRW 769
Cdd:COG1232  314 EGVPILAVTFssnkwpHRAPDGKVLLRLEVGGAGDPELWQLSDEELVALALADLRKLLGID--AEPVDTRVVRW 385
PRK07233 PRK07233
hypothetical protein; Provisional
 591-669 1.18e-09

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 61.44  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982477 591 GYSTIIEKLAE-----GLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaiqFNPPLSEK---KMK 662
Cdd:PRK07233 196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                 ....*..
gi 568982477 663 AINSLGA 669
Cdd:PRK07233 272 RIDYQGV 278
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 6.06e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.61  E-value: 6.06e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568982477  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 305-376 5.64e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 5.64e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568982477  305 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 376
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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