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Conserved domains on  [gi|568955903|ref|XP_006530622|]
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alanine aminotransferase 2 isoform X2 [Mus musculus]

Protein Classification

alanine aminotransferase( domain architecture ID 1002570)

alanine aminotransferase catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate

CATH:  3.40.640.10|1.10.287.1970|3.90.1150.10
EC:  2.6.1.2
Gene Ontology:  GO:0009058|GO:0030170|GO:0004021

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00377 super family cl30205
alanine aminotransferase; Provisional
 39-290 3.98e-132

alanine aminotransferase; Provisional


The actual alignment was detected with superfamily member PTZ00377:

Pssm-ID: 240391 [Multi-domain]  Cd Length: 481  Bit Score: 383.16  E-value: 3.98e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGHEYSSNVELASFHSTSKGYMGECGYRG 118
Cdd:PTZ00377 230 PTGQVLTRDVMEEIIKFCYEKGIVLMADEVYQENIYDGEKPFISFRKVLLELPAEYNTDVELVSFHSTSKGIIGECGRRG 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLTEDLFNQVPGIQ 198
Cdd:PTZ00377 310 GYFELTNIPPEVREQIYKLASINLCSNVVGQLMTGLMCNPPREGDASYPLYKRERDAIFTSLKRRAELLTDELNKIEGVS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 199 CNPLQGAMYAFPRILIPAKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVDKLKTVLHKV 278
Cdd:PTZ00377 390 CQPVEGAMYAFPRIELPEKAIQEAKERGLAPDVLYCLELLESTGIVVVPGSGFGQKPGTYHFRITILPPEEQIEEMVKKI 469

                        250
                 ....*....|..
gi 568955903 279 KDFHLKFLEQYS 290
Cdd:PTZ00377 470 KEFHESFMKKYG 481
 
Name Accession Description Interval E-value
PTZ00377 PTZ00377
alanine aminotransferase; Provisional
 39-290 3.98e-132

alanine aminotransferase; Provisional


Pssm-ID: 240391 [Multi-domain]  Cd Length: 481  Bit Score: 383.16  E-value: 3.98e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGHEYSSNVELASFHSTSKGYMGECGYRG 118
Cdd:PTZ00377 230 PTGQVLTRDVMEEIIKFCYEKGIVLMADEVYQENIYDGEKPFISFRKVLLELPAEYNTDVELVSFHSTSKGIIGECGRRG 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLTEDLFNQVPGIQ 198
Cdd:PTZ00377 310 GYFELTNIPPEVREQIYKLASINLCSNVVGQLMTGLMCNPPREGDASYPLYKRERDAIFTSLKRRAELLTDELNKIEGVS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 199 CNPLQGAMYAFPRILIPAKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVDKLKTVLHKV 278
Cdd:PTZ00377 390 CQPVEGAMYAFPRIELPEKAIQEAKERGLAPDVLYCLELLESTGIVVVPGSGFGQKPGTYHFRITILPPEEQIEEMVKKI 469

                        250
                 ....*....|..
gi 568955903 279 KDFHLKFLEQYS 290
Cdd:PTZ00377 470 KEFHESFMKKYG 481
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 39-289 2.03e-25

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 104.06  E-value: 2.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpDCRFHSFKKVlyqmgHEYSSNVelASFHSTSKGY-MgeCGYR 117
Cdd:COG0436  175 PTGAVYSREELEALAELAREHDLLVISDEIYEELVYD-GAEHVSILSL-----PGLKDRT--IVINSFSKSYaM--TGWR 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 118 GGYMEVinlHPEIKGQLVKLLS-VRLCPPVSGQAAMDIVVNPPEpgeESFEQFSREkefvlgnLAKKAKLTEDLFNQVpG 196
Cdd:COG0436  245 IGYAVG---PPELIAALLKLQSnLTSCAPTPAQYAAAAALEGPQ---DYVEEMRAE-------YRRRRDLLVEGLNEI-G 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 197 IQCNPLQGAMYAFPRIlipakaveaaqSHKMAPDMFYCMKLLEETGICVVPGSGFGqREGTYHFRMTILPPVDKLKTVLH 276
Cdd:COG0436  311 LSVVKPEGAFYLFADV-----------PELGLDSEEFAERLLEEAGVAVVPGSAFG-PAGEGYVRISYATSEERLEEALE 378

                        250
                 ....*....|...
gi 568955903 277 KVKdfhlKFLEQY 289
Cdd:COG0436  379 RLA----RFLERY 387
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 39-280 4.33e-23

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 97.03  E-value: 4.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCrfHSFKKVLYQMGHeyssnveLASFHSTSKGYmGECGYRG 118
Cdd:cd00609  144 PTGAVLSEEELEELAELAKKHGILIISDEAYAELVYDGEP--PPALALLDAYER-------VIVLRSFSKTF-GLPGLRI 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVINlhPEIKGQLVKLLSVR-LCPPVSGQAAMDIVVNPPEpgeesfeqfsREKEFVLGNLAKKAKLTEDLFNQVPGI 197
Cdd:cd00609  214 GYLIAPP--EELLERLKKLLPYTtSGPSTLSQAAAAAALDDGE----------EHLEELRERYRRRRDALLEALKELGPL 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 198 QCNPLQGAMYAFPRIlipakaveaaqshKMAPDMFYCMKLLEETGICVVPGSGFGQrEGTYHFRMTILPPVDKLKTVLHK 277
Cdd:cd00609  282 VVVKPSGGFFLWLDL-------------PEGDDEEFLERLLLEAGVVVRPGSAFGE-GGEGFVRLSFATPEEELEEALER 347


                 ...
gi 568955903 278 VKD 280
Cdd:cd00609  348 LAE 350
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 37-281 1.70e-17

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 81.62  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903   37 PCpgGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYsPDCRFhsfkkvlYQMGhEYSSNVELASFHSTSKGYMGEcGY 116
Cdd:TIGR01265 181 PC--GSVFSRDHLQKIAEVAEKLGIPIIADEIYGHMVF-GDAPF-------IPMA-SFASIVPVLSLGGISKRWVVP-GW 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  117 RGGYMEVINLH----PEIKGQLVKLLSVRLCPPVSGQAAM-DIVVNPPEpgeesfEQFSRekefVLGNLAKKAKLTEDLF 191
Cdd:TIGR01265 249 RLGWIIIHDPHgifrDTVLQGLKNLLQRILGPATIVQGALpDILENTPQ------EFFDG----KISVLKSNAELCYEEL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  192 NQVPGIQCNPLQGAMYAFPRIlipakavEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREgtyHFRMTILPPVDKL 271
Cdd:TIGR01265 319 KDIPGLVCPKPEGAMYLMVKL-------ELELFPEIKDDVDFCEKLAREESVICLPGSAFGLPN---WVRITITVPESML 388

                         250
                  ....*....|
gi 568955903  272 KTVLHKVKDF 281
Cdd:TIGR01265 389 EEACSRIKEF 398
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
39-264 3.15e-10

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 60.01  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903   39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPdcrfHSFKKVLYQMGHEyssnVELASFHSTSKGyMGECGYRG 118
Cdd:pfam00155 148 PTGTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFGS----PDAVATRALLAEG----PNLLVVGSFSKA-FGLAGWRV 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  119 GYmevINLHPEIKGQLVKLLSvRLCPPVSGQAAMDIVVNPPEpGEESFEQFSREKefvlgnLAKKAK-LTEDLfnQVPGI 197
Cdd:pfam00155 219 GY---ILGNAAVISQLRKLAR-PFYSSTHLQAAAAAALSDPL-LVASELEEMRQR------IKERRDyLRDGL--QAAGL 285

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568955903  198 QCNPLQGAMYAFPRiLIPAKAVEAAQshkmapdmfycmKLLEETGICVVPGSGFGQREgtyHFRMTI 264
Cdd:pfam00155 286 SVLPSQAGFFLLTG-LDPETAKELAQ------------VLLEEVGVYVTPGSSPGVPG---WLRITV 336
 
Name Accession Description Interval E-value
PTZ00377 PTZ00377
alanine aminotransferase; Provisional
 39-290 3.98e-132

alanine aminotransferase; Provisional


Pssm-ID: 240391 [Multi-domain]  Cd Length: 481  Bit Score: 383.16  E-value: 3.98e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGHEYSSNVELASFHSTSKGYMGECGYRG 118
Cdd:PTZ00377 230 PTGQVLTRDVMEEIIKFCYEKGIVLMADEVYQENIYDGEKPFISFRKVLLELPAEYNTDVELVSFHSTSKGIIGECGRRG 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLTEDLFNQVPGIQ 198
Cdd:PTZ00377 310 GYFELTNIPPEVREQIYKLASINLCSNVVGQLMTGLMCNPPREGDASYPLYKRERDAIFTSLKRRAELLTDELNKIEGVS 389

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 199 CNPLQGAMYAFPRILIPAKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVDKLKTVLHKV 278
Cdd:PTZ00377 390 CQPVEGAMYAFPRIELPEKAIQEAKERGLAPDVLYCLELLESTGIVVVPGSGFGQKPGTYHFRITILPPEEQIEEMVKKI 469

                        250
                 ....*....|..
gi 568955903 279 KDFHLKFLEQYS 290
Cdd:PTZ00377 470 KEFHESFMKKYG 481
PLN02231 PLN02231
alanine transaminase
 39-289 5.28e-102

alanine transaminase


Pssm-ID: 177876 [Multi-domain]  Cd Length: 534  Bit Score: 308.02  E-value: 5.28e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGHEySSNVELASFHSTSKGYMGECGYRG 118
Cdd:PLN02231 283 PTGQVLAEENQRDIVEFCKQEGLVLLADEVYQENVYVPDKKFHSFKKVARSMGYG-EKDISLVSFQSVSKGYYGECGKRG 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLTEDLFNQVPGIQ 198
Cdd:PLN02231 362 GYMEVTGFTSDVREQIYKVASVNLCSNISGQILASLVMSPPKPGDESYESYMAEKDGILSSLARRAKTLEDALNSLEGVT 441

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 199 CNPLQGAMYAFPRILIPAKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTYHFRMTILPPVDKLKTVLHKV 278
Cdd:PLN02231 442 CNKAEGAMYLFPRIHLPQKAIKAAEAAKTAPDAFYCKRLLNATGIVVVPGSGFGQVPGTWHFRCTILPQEDKIPAIVSRL 521

                        250
                 ....*....|.
gi 568955903 279 KDFHLKFLEQY 289
Cdd:PLN02231 522 TEFHKSFMDEF 532
PLN02368 PLN02368
alanine transaminase
 39-223 1.01e-68

alanine transaminase


Pssm-ID: 177996 [Multi-domain]  Cd Length: 407  Bit Score: 218.52  E-value: 1.01e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVLYQMGHEYSSNVELASFHSTSKGYMGECGYRG 118
Cdd:PLN02368 222 PTGQCLSEANLREILKFCYQERLVLLGDEVYQQNIYQDERPFISAKKVLMDMGPPISKEVQLVSFHTVSKGYWGECGQRG 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLAKKAKLTEDLFNQVPGIQ 198
Cdd:PLN02368 302 GYFEMTNIPPKTVEEIYKVASIALSPNVSGQIFMGLMVNPPKPGDISYDQFVRESKGILESLRRRARMMTDGFNSCKNVV 381

                        170       180
                 ....*....|....*....|....*
gi 568955903 199 CNPLQGAMYAFPRILIPAKAVEAAQ 223
Cdd:PLN02368 382 CNFTEGAMYSFPQIKLPPKAIEAAR 406
PRK08363 PRK08363
alanine aminotransferase; Validated
 4-281 2.04e-27

alanine aminotransferase; Validated


Pssm-ID: 181402  Cd Length: 398  Bit Score: 109.51  E-value: 2.04e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903   4 WQPDVKGHSFPVSD---FIALVRSGAcshdwslallpcPGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYspDCRF 80
Cdd:PRK08363 152 WQPDIDDIRKKITEktkAIAVINPNN------------PTGALYEKKTLKEILDIAGEHDLPVISDEIYDLMTY--EGKH 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  81 HSFKKVlyqmgheySSNVELASFHSTSKGYMGEcGYRGGYMEVINLHP---EIKGQLVKLLSVRLCPPVSGQ-AAMDIVV 156
Cdd:PRK08363 218 VSPGSL--------TKDVPVIVMNGLSKVYFAT-GWRLGYIYFVDPEGklaEVREAIDKLARIRLCPNTPAQfAAIAGLT 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 157 NPPEPGEESFEQFSREKEFVLGNLakkakltedlfNQVPGIQCNPLQGAMYAFPRIlipakaveaaQSHKMAPDMFYCMK 236
Cdd:PRK08363 289 GPMDYLEEYMKKLKERRDYIYKRL-----------NEIPGISTTKPQGAFYIFPRI----------EEGPWKDDKEFVLD 347

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 568955903 237 LLEETGICVVPGSGFGqREGTYHFRMTILPPVDKLKTVLHKVKDF 281
Cdd:PRK08363 348 VLHEAHVLFVHGSGFG-EYGAGHFRLVFLPPVEILEEAMDRFEEF 391
PRK09265 PRK09265
aminotransferase AlaT; Validated
 39-289 2.75e-27

aminotransferase AlaT; Validated


Pssm-ID: 181738  Cd Length: 404  Bit Score: 109.13  E-value: 2.75e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQdnvyspdcrfhsfkKVLYQmGHEYSSNVELA------SFHSTSKGYMG 112
Cdd:PRK09265 180 PTGAVYSKELLEEIVEIARQHNLIIFADEIYD--------------KILYD-GAVHISIASLApdllcvTFNGLSKAYRV 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 113 eCGYRGGYMeVIN---LHPE--IKGqLVKLLSVRLCPPVSGQAAMDIVVNppepGEESFEqfsrekEFVL--GNLAKKAK 185
Cdd:PRK09265 245 -AGFRVGWM-VLSgpkKHAKgyIEG-LDMLASMRLCANVPAQHAIQTALG----GYQSIN------ELILpgGRLYEQRD 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 186 LTEDLFNQVPGIQCNPLQGAMYAFPRiLIPAKaveaaqsHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTyHFRMTIL 265
Cdd:PRK09265 312 RAWELLNAIPGVSCVKPKGALYAFPK-LDPKV-------YPIHDDEQFVLDLLLQEKVLLVQGTGFNWPEPD-HFRIVTL 382

                        250       260
                 ....*....|....*....|....
gi 568955903 266 PPVDKLKTVLHKVKdfhlKFLEQY 289
Cdd:PRK09265 383 PRVDDLEEAIGRIG----RFLSGY 402
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 39-289 2.03e-25

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 104.06  E-value: 2.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpDCRFHSFKKVlyqmgHEYSSNVelASFHSTSKGY-MgeCGYR 117
Cdd:COG0436  175 PTGAVYSREELEALAELAREHDLLVISDEIYEELVYD-GAEHVSILSL-----PGLKDRT--IVINSFSKSYaM--TGWR 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 118 GGYMEVinlHPEIKGQLVKLLS-VRLCPPVSGQAAMDIVVNPPEpgeESFEQFSREkefvlgnLAKKAKLTEDLFNQVpG 196
Cdd:COG0436  245 IGYAVG---PPELIAALLKLQSnLTSCAPTPAQYAAAAALEGPQ---DYVEEMRAE-------YRRRRDLLVEGLNEI-G 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 197 IQCNPLQGAMYAFPRIlipakaveaaqSHKMAPDMFYCMKLLEETGICVVPGSGFGqREGTYHFRMTILPPVDKLKTVLH 276
Cdd:COG0436  311 LSVVKPEGAFYLFADV-----------PELGLDSEEFAERLLEEAGVAVVPGSAFG-PAGEGYVRISYATSEERLEEALE 378

                        250
                 ....*....|...
gi 568955903 277 KVKdfhlKFLEQY 289
Cdd:COG0436  379 RLA----RFLERY 387
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 39-280 4.33e-23

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 97.03  E-value: 4.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCrfHSFKKVLYQMGHeyssnveLASFHSTSKGYmGECGYRG 118
Cdd:cd00609  144 PTGAVLSEEELEELAELAKKHGILIISDEAYAELVYDGEP--PPALALLDAYER-------VIVLRSFSKTF-GLPGLRI 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVINlhPEIKGQLVKLLSVR-LCPPVSGQAAMDIVVNPPEpgeesfeqfsREKEFVLGNLAKKAKLTEDLFNQVPGI 197
Cdd:cd00609  214 GYLIAPP--EELLERLKKLLPYTtSGPSTLSQAAAAAALDDGE----------EHLEELRERYRRRRDALLEALKELGPL 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 198 QCNPLQGAMYAFPRIlipakaveaaqshKMAPDMFYCMKLLEETGICVVPGSGFGQrEGTYHFRMTILPPVDKLKTVLHK 277
Cdd:cd00609  282 VVVKPSGGFFLWLDL-------------PEGDDEEFLERLLLEAGVVVRPGSAFGE-GGEGFVRLSFATPEEELEEALER 347


                 ...
gi 568955903 278 VKD 280
Cdd:cd00609  348 LAE 350
tyr_nico_aTase TIGR01265
tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal ...
 37-281 1.70e-17

tyrosine/nicotianamine family aminotransferase; This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley.


Pssm-ID: 188123  Cd Length: 403  Bit Score: 81.62  E-value: 1.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903   37 PCpgGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYsPDCRFhsfkkvlYQMGhEYSSNVELASFHSTSKGYMGEcGY 116
Cdd:TIGR01265 181 PC--GSVFSRDHLQKIAEVAEKLGIPIIADEIYGHMVF-GDAPF-------IPMA-SFASIVPVLSLGGISKRWVVP-GW 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  117 RGGYMEVINLH----PEIKGQLVKLLSVRLCPPVSGQAAM-DIVVNPPEpgeesfEQFSRekefVLGNLAKKAKLTEDLF 191
Cdd:TIGR01265 249 RLGWIIIHDPHgifrDTVLQGLKNLLQRILGPATIVQGALpDILENTPQ------EFFDG----KISVLKSNAELCYEEL 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  192 NQVPGIQCNPLQGAMYAFPRIlipakavEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREgtyHFRMTILPPVDKL 271
Cdd:TIGR01265 319 KDIPGLVCPKPEGAMYLMVKL-------ELELFPEIKDDVDFCEKLAREESVICLPGSAFGLPN---WVRITITVPESML 388

                         250
                  ....*....|
gi 568955903  272 KTVLHKVKDF 281
Cdd:TIGR01265 389 EEACSRIKEF 398
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 39-281 3.13e-15

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 75.54  E-value: 3.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpdcrfhsfkkvlyqmGHEYSSNVELA------SFHSTSKGYMg 112
Cdd:PRK13355 293 PTGALYPREVLQQIVDIAREHQLIIFSDEIYDRLVMD---------------GLEHTSIASLApdlfcvTFSGLSKSHM- 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 113 ECGYRGGYMeVINLHPE-----IKGqLVKLLSVRLCPPVSGQAAMDIVVNppepGEESFEQFSREKefvlGNLAKKAKLT 187
Cdd:PRK13355 357 IAGYRIGWM-ILSGNKRiakdyIEG-LNMLANMRLCSNVPAQSIVQTALG----GHQSVKDYLVPG----GRVYEQRELV 426

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 188 EDLFNQVPGIQCNPLQGAMYAFPRIlipakaveAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTyHFRMTILPP 267
Cdd:PRK13355 427 YNALNAIPGISAVKPKAAFYIFPKI--------DVKKFNIHDDEQFALDLLHDKKVLIVQGTGFNWDKPD-HFRVVYLPR 497

                        250
                 ....*....|....
gi 568955903 268 VDKLKTVLHKVKDF 281
Cdd:PRK13355 498 LEDLEDAMDRLADF 511
PRK05764 PRK05764
aspartate aminotransferase; Provisional
 39-262 5.62e-15

aspartate aminotransferase; Provisional


Pssm-ID: 235596  Cd Length: 393  Bit Score: 74.39  E-value: 5.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpDCRFHSfkkvLYQMGHEYSSN-VELASFhstSKGY-MgeCGY 116
Cdd:PRK05764 176 PTGAVYSPEELEAIADVAVEHDIWVLSDEIYEKLVYD-GAEFTS----IASLSPELRDRtITVNGF---SKAYaM--TGW 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 117 RGGYM----EVINLHPEIKGQLVkllsvrLCPP-VSGQAAMDIVVNPPEPGEESFEQFSREKEFVLgnlakkaklteDLF 191
Cdd:PRK05764 246 RLGYAagpkELIKAMSKLQSHST------SNPTsIAQYAAVAALNGPQDEVEEMRQAFEERRDLMV-----------DGL 308

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568955903 192 NQVPGIQCNPLQGAMYAFPRilipakaVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFGQREgtyHFRM 262
Cdd:PRK05764 309 NEIPGLECPKPEGAFYVFPN-------VSKLLGKSITDSLEFAEALLEEAGVAVVPGIAFGAPG---YVRL 369
tyr_amTase_E TIGR01264
tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found ...
 39-281 1.24e-14

tyrosine aminotransferase, eukaryotic; This model describes tyrosine aminotransferase as found in animals and Trypanosoma cruzi. It is the first enzyme of a pathway of tyrosine degradation via homogentisate. Several plant enzyme designated as probable tyrosine aminotransferases are very closely related to an experimentally demonstrated nicotianamine aminotransferase, an enzyme in a siderophore (iron uptake chelator) biosynthesis pathway. These plant sequences are excluded from the model seed and score between the trusted an noise cutoffs. [Energy metabolism, Amino acids and amines]


Pssm-ID: 273529 [Multi-domain]  Cd Length: 401  Bit Score: 73.28  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903   39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYsPDCRFHSFKkvlyqmghEYSSNVELASFHSTSKGYMGEcGYRG 118
Cdd:TIGR01264 180 PCGSVFSRQHLEEILAVAERQCLPIIADEIYGDMVF-SGATFEPLA--------SLSSTVPILSCGGLAKRWLVP-GWRL 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  119 GYMEVINLHPEIKGQLVKL--LSVRLCPPVS-GQAAM-DIVVNPPepgEESFeqfsrekEFVLGNLAKKAKLTEDLFNQV 194
Cdd:TIGR01264 250 GWIIIHDRRGILRDIRDGLvkLSQRILGPCTiVQGALpSILLRTP---QEYF-------DGTLSVLESNAMLCYGALAAV 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  195 PGIQCNPLQGAMYAFPRIlipakavEAAQSHKMAPDMFYCMKLLEETGICVVPGSGFgqrEGTYHFRMTILPPVDKLKTV 274
Cdd:TIGR01264 320 PGLRPVMPSGAMYMMVGI-------EMEHFPEFKNDVEFTERLVAEQSVFCLPGSCF---EYPGFFRVVLTVPVVMMEEA 389


                  ....*..
gi 568955903  275 LHKVKDF 281
Cdd:TIGR01264 390 CSRIQEF 396
PRK07682 PRK07682
aminotransferase;
34-281 7.24e-12

aminotransferase;


Pssm-ID: 181082 [Multi-domain]  Cd Length: 378  Bit Score: 65.14  E-value: 7.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  34 ALLPC----PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYspDCRFHSFKKVlyqmGHEYSSNVELASFhstSKG 109
Cdd:PRK07682 157 AILLCspnnPTGAVLNKSELEEIAVIVEKHDLIVLSDEIYAELTY--DEAYTSFASI----KGMRERTILISGF---SKG 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 110 YmGECGYRGGYmevINLHPEIKGQLVKLLSVRL-CPPVSGQ-AAMDIVVNPPEPGEESFEQFSREKEFVLGNLakkaklt 187
Cdd:PRK07682 228 F-AMTGWRLGF---IAAPVYFSEAMLKIHQYSMmCAPTMAQfAALEALRAGNDDVIRMRDSYRKRRNFFVTSF------- 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 188 edlfNQVpGIQCNPLQGAMYAFPRIlipakaveaaQSHKMAPDMFyCMKLLEETGICVVPGSGFGQrEGTYHFRMTILPP 267
Cdd:PRK07682 297 ----NEI-GLTCHVPGGAFYAFPSI----------SSTGLSSEEF-AEQLLLEEKVAVVPGSVFGE-SGEGFIRCSYATS 359

                        250
                 ....*....|....
gi 568955903 268 VDKLKTVLHKVKDF 281
Cdd:PRK07682 360 LEQLQEAMKRMKRF 373
PTZ00433 PTZ00433
tyrosine aminotransferase; Provisional
 37-281 9.74e-12

tyrosine aminotransferase; Provisional


Pssm-ID: 185613  Cd Length: 412  Bit Score: 64.81  E-value: 9.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  37 PCpgGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDcrfhSFKKVLyqmghEYSSNVELASFHSTSKGYMgeC-G 115
Cdd:PTZ00433 189 PC--GSNFSRKHVEDIIRLCEELRLPLISDEIYAGMVFNGA----TFTSVA-----DFDTTVPRVILGGTAKNLV--VpG 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 116 YRGGYMEVINLHPE----IKGqlVKLLSVRLCPPVS-GQAAM-DIVVNPPepgEESFEQFSREKEfvlgnlaKKAKLTED 189
Cdd:PTZ00433 256 WRLGWLLLVDPHGNggdfLDG--MKRLGMLVCGPCSvVQAALgEALLNTP---QEHLEQIVAKLE-------EGAMVLYN 323

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 190 LFNQVPGIQCNPLQGAMYAFPRIlipakAVEAAQSHKmaPDMFYCMKLLEETGICVVPGSGFGQregTYHFRMTILPPVD 269
Cdd:PTZ00433 324 HIGECIGLSPTMPRGSMFLMSRL-----DLEKFRDIK--SDVEFYEKLLEEENVQVLPGEIFHM---PGFTRLTISRPVE 393

                        250
                 ....*....|..
gi 568955903 270 KLKTVLHKVKDF 281
Cdd:PTZ00433 394 VLREAVERIKAF 405
PRK06855 PRK06855
pyridoxal phosphate-dependent aminotransferase;
39-265 6.10e-11

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180734  Cd Length: 433  Bit Score: 62.27  E-value: 6.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpDCRFHSFKKVLyqmgheysSNVELASFHSTSKGYMGEcGYRG 118
Cdd:PRK06855 183 PTGAVYPKEILREIVDIAREYDLFIICDEIYNNIVYN-GKKTVPLSEVI--------GDVPGIALKGISKELPWP-GSRC 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMEVIN------LHPEIKGQL-VKLLSVrlCPPVSGQAAMDIVVNPPEpgeesFEQFSREKefvLGNLAKKAKLTEDLF 191
Cdd:PRK06855 253 GWIEVYNadkdevFKKYINSILnAKMIEV--CSTTLPQMAIPRIMSHPE-----YKNYLKER---NKRYEKRSNIAYEKL 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 192 NQVPGIQCNPLQGAMY---AF------PRILIP------AKAVEAAQSHKMAPDMFYCMKLLEETGICVVPGSGF-GQRE 255
Cdd:PRK06855 323 KDVPGLKVNRTNGAFYmtvVFedgvlnNKQSLPienpevKEYVEGLVKGPVSPDKRFVYYLLASTGICVVPLSSFcTELN 402

                        250
                 ....*....|
gi 568955903 256 GtyhFRMTIL 265
Cdd:PRK06855 403 G---FRVTLL 409
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
39-264 3.15e-10

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 60.01  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903   39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPdcrfHSFKKVLYQMGHEyssnVELASFHSTSKGyMGECGYRG 118
Cdd:pfam00155 148 PTGTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFGS----PDAVATRALLAEG----PNLLVVGSFSKA-FGLAGWRV 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  119 GYmevINLHPEIKGQLVKLLSvRLCPPVSGQAAMDIVVNPPEpGEESFEQFSREKefvlgnLAKKAK-LTEDLfnQVPGI 197
Cdd:pfam00155 219 GY---ILGNAAVISQLRKLAR-PFYSSTHLQAAAAAALSDPL-LVASELEEMRQR------IKERRDyLRDGL--QAAGL 285

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568955903  198 QCNPLQGAMYAFPRiLIPAKAVEAAQshkmapdmfycmKLLEETGICVVPGSGFGQREgtyHFRMTI 264
Cdd:pfam00155 286 SVLPSQAGFFLLTG-LDPETAKELAQ------------VLLEEVGVYVTPGSSPGVPG---WLRITV 336
PRK06108 PRK06108
pyridoxal phosphate-dependent aminotransferase;
39-252 9.77e-10

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180404  Cd Length: 382  Bit Score: 58.80  E-value: 9.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPDCRFHSFKKVlyqmgheYSSNVELASFHSTSKGY-MgeCGYR 117
Cdd:PRK06108 170 PTGWTASRDDLRAILAHCRRHGLWIVADEVYERLYYAPGGRAPSFLDI-------AEPDDRIIFVNSFSKNWaM--TGWR 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 118 GGYMEvinLHPEIKGQLVKLL----SvrlCPPVSGQAAmdivvnppepGEESFEQfsrEKEFVLGNLAKkAKLTEDL--- 190
Cdd:PRK06108 241 LGWLV---APPALGQVLEKLIeyntS---CVAQFVQRA----------AVAALDE---GEDFVAELVAR-LRRSRDHlvd 300

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568955903 191 -FNQVPGIQCNPLQGAMYAFPRIlipakaveAAQSHKMApdmfYCMKLLEETGICVVPGSGFG 252
Cdd:PRK06108 301 aLRALPGVEVAKPDGAMYAFFRI--------PGVTDSLA----LAKRLVDEAGLGLAPGTAFG 351
PRK07568 PRK07568
pyridoxal phosphate-dependent aminotransferase;
37-257 1.70e-08

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 181036  Cd Length: 397  Bit Score: 54.86  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  37 PC-PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpDCRFHSFkkvlyqmGH--EYSSNVELASfhSTSKGYmGE 113
Cdd:PRK07568 171 PGnPTGVVYTKEELEMLAEIAKKHDLFLISDEVYREFVYD-GLKYTSA-------LSleGLEDRVIIID--SVSKRY-SA 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 114 CGYRGGYmeVINLHPEIKGQLVKLLSVRLCPPVSGQAAMDIVVNPPepgEESFEQFSREKEfvlgnlaKKAKLTEDLFNQ 193
Cdd:PRK07568 240 CGARIGC--LISKNKELIAAAMKLCQARLSPPTLEQIGAAALLDTP---ESYFDEVREEYK-------KRRDILYEELNK 307

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568955903 194 VPGIQCNPLQGAMYAFprilipAK-AVEAAQShkmapdmfYCMKLLE------ETgICVVPGSGFGQREGT 257
Cdd:PRK07568 308 IPGVVCEKPKGAFYII------AKlPVDDAED--------FAKWLLTdfnyngET-VMVAPASGFYATPGL 363
PRK06348 PRK06348
pyridoxal phosphate-dependent aminotransferase;
39-272 2.39e-07

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180537  Cd Length: 384  Bit Score: 51.26  E-value: 2.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSPD-CRFHSFKKVlyqmgheYSSNVELASFhstSKGYmGECGYR 117
Cdd:PRK06348 174 PTGAVFSKETLEEIAKIAIEYDLFIISDEVYDGFSFYEDfVPMATLAGM-------PERTITFGSF---SKDF-AMTGWR 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 118 GGYMevinLHPEIKGQLVKLLSVRLC---PPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLgnlakkaklteDLFNQV 194
Cdd:PRK06348 243 IGYV----IAPDYIIETAKIINEGICfsaPTISQRAAIYALKHRDTIVPLIKEEFQKRLEYAY-----------KRIESI 307

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568955903 195 PGIQCNPLQGAMYAFprILIPAKAVEAAQshkmapdmfYCMKLLEETGICVVPGSGFGQrEGTYHFRMTILPPVDKLK 272
Cdd:PRK06348 308 PNLSLHPPKGSIYAF--INIKKTGLSSVE---------FCEKLLKEAHVLVIPGKAFGE-SGEGYIRLACTVGIEVLE 373
PRK05957 PRK05957
pyridoxal phosphate-dependent aminotransferase;
39-258 6.63e-07

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235654  Cd Length: 389  Bit Score: 50.07  E-value: 6.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVY------SPDcrfhsfkkvlyQMGHEYSSNVELASFhstSKGYmG 112
Cdd:PRK05957 172 PTGVVYPEALLRAVNQICAEHGIYHISDEAYEYFTYdgvkhfSPG-----------SIPGSGNHTISLYSL---SKAY-G 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 113 ECGYRGGYMeVINLHpeikgqLVKLL-----SVRLCPPVSGQAAmdiVVNPPEPGEESFEQFsrekefvLGNLAKKAKLT 187
Cdd:PRK05957 237 FASWRIGYM-VIPIH------LLEAIkkiqdTILICPPVVSQYA---ALGALQVGKSYCQQH-------LPEIAQVRQIL 299

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568955903 188 EDLFNQVPGI-QCNPLQGAMYAFPRIlipakaveaaqsHKMAPDMFYCMKLLEETGICVVPGSGFGQREGTY 258
Cdd:PRK05957 300 LKSLGQLQDRcTLHPANGAFYCFLKV------------NTDLNDFELVKQLIREYRVAVIPGTTFGMKNGCY 359
PRK07683 PRK07683
aminotransferase A; Validated
 37-281 2.39e-06

aminotransferase A; Validated


Pssm-ID: 236075  Cd Length: 387  Bit Score: 48.18  E-value: 2.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  37 PC-PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYspDCRFHSFKKVLYQMGHEYSSNvELASFHSTSkgymgecG 115
Cdd:PRK07683 170 PSnPTGVTLSKEELQDIADVLKDKNIFVLSDEIYSELVY--EQPHTSIAHFPEMREKTIVIN-GLSKSHSMT-------G 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 116 YRGGYMevinLHPE-IKGQLVKL--LSVRLCPPVSGQAAMDIVVNPPEPGEESFEQFSREKEFVLGNLakkakLTEDLFN 192
Cdd:PRK07683 240 WRIGFL----FAPSyLAKHILKVhqYNVTCASSISQYAALEALTAGKDDAKMMRHQYKKRRDYVYNRL-----ISMGLDV 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 193 QVPgiqcnplQGAMYAFPRIlipakaveaaQSHKMAPDMFyCMKLLEETGICVVPGSGFGQReGTYHFRMTILPPVDKLK 272
Cdd:PRK07683 311 EKP-------TGAFYLFPSI----------GHFTMSSFDF-ALDLVEEAGLAVVPGSAFSEY-GEGYVRLSYAYSIETLK 371


                 ....*....
gi 568955903 273 TVLHKVKDF 281
Cdd:PRK07683 372 EGLDRLEAF 380
PRK08361 PRK08361
aspartate aminotransferase; Provisional
 39-279 1.11e-05

aspartate aminotransferase; Provisional


Pssm-ID: 236248 [Multi-domain]  Cd Length: 391  Bit Score: 46.41  E-value: 1.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpDCRFhsfkkvlYQMGHEYSSNVELASfhSTSKGYmGECGYRG 118
Cdd:PRK08361 178 PTGATLDKEVAKAIADIAEDYNIYILSDEPYEHFLYE-GAKH-------YPMIKYAPDNTILAN--SFSKTF-AMTGWRL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYM--------EVINLHPEIKGQLVKLLSVrlcppvSGQAAMDivvnppepGEESFEQFSR-EKEFvlgnlAKKAKLTED 189
Cdd:PRK08361 247 GFViapeqvikDMIKLHAYIIGNVASFVQI------AGIEALR--------SKESWKAVEEmRKEY-----NERRKLVLK 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 190 LFNQVPGIQCNPLQGAMYAFPRIlipakaveaaQSHKMAPDMFyCMKLLEETGICVVPGSGFGqREGTYHFRMTILPPVD 269
Cdd:PRK08361 308 RLKEMPHIKVFEPKGAFYVFANI----------DETGMSSEDF-AEWLLEKARVVVIPGTAFG-KAGEGYIRISYATSKE 375

                        250
                 ....*....|
gi 568955903 270 KLKTVLHKVK 279
Cdd:PRK08361 376 KLIEAMERME 385
PLN00143 PLN00143
tyrosine/nicotianamine aminotransferase; Provisional
 39-281 2.23e-05

tyrosine/nicotianamine aminotransferase; Provisional


Pssm-ID: 165711 [Multi-domain]  Cd Length: 409  Bit Score: 45.39  E-value: 2.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQDNVYSpdcrfhsfKKVLYQMGhEYSSNVELASFHSTSKGYMGEcGYRG 118
Cdd:PLN00143 182 PCGSVYSYEHLNKIAETARKLGILVIADEVYGHIVFG--------SKPFVPMG-LFASIVPVITLGSISKRWMIP-GWGL 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 119 GYMevINLHP-------EIKGQLVKLLSVRLCPPVSGQAAMdivvnpPEPGEESFEQFSREkefVLGNLAKKAKLTEDLF 191
Cdd:PLN00143 252 GWL--VTCDPsgllqicEIADSIKKALNPAPFPPTFIQAAI------PEILEKTTEDFFSK---TINILRAALAFCYDKL 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 192 NQVPGIQC-NPLQGAMYAFPRI-LIPAKAVEaaqshkmaPDMFYCMKLLEETGICVVPGSGFGQREgtyHFRMTILPPVD 269
Cdd:PLN00143 321 KEIPCIMCpQKAEGAFFALVKLnLLLLEDIE--------DDMEFCLKLAKEESLIILPGVTVGLKN---WLRITFAVEQS 389

                        250
                 ....*....|..
gi 568955903 270 KLKTVLHKVKDF 281
Cdd:PLN00143 390 SLEDGLGRLKSF 401
PRK06107 PRK06107
aspartate transaminase;
190-273 1.79e-04

aspartate transaminase;


Pssm-ID: 180403  Cd Length: 402  Bit Score: 42.41  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 190 LFNQVPGIQCNPLQGAMYAFPRI--LIPAKAVEAAqshKMAPDMFYCMKLLEETGICVVPGSGFGQREgtyHFRMTILPP 267
Cdd:PRK06107 310 LLNAIPGLSCLVPDGAFYLYVNCagLIGKTTPEGK---VLETDQDVVLYLLDSAGVAVVQGTAYGLSP---YFRLSIATS 383


                 ....*.
gi 568955903 268 VDKLKT 273
Cdd:PRK06107 384 LETLEE 389
PRK05942 PRK05942
aspartate aminotransferase; Provisional
 39-285 2.48e-04

aspartate aminotransferase; Provisional


Pssm-ID: 180317  Cd Length: 394  Bit Score: 42.01  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903  39 PGGQVQSRKCIEDVIHFAWEEKLFLLADEVYQD---NVYSPDCrfhsfkkvLYQMGHEYSSNVElasFHSTSKGY-MGec 114
Cdd:PRK05942 182 PTTATAPREFFEEIVAFARKYEIMLVHDLCYAElafDGYQPTS--------LLEIPGAKDIGVE---FHTLSKTYnMA-- 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 115 GYRGGYMeVINLHPeIKGqlVKLLSVRLCPPVSG--QAAMDIVVNPPEPGEESFEQFSREK-EFVLGNLAKKakltedlf 191
Cdd:PRK05942 249 GWRVGFV-VGNRHI-IQG--LRTLKTNLDYGIFSalQKAAETALQLPDSYLQQVQERYRTRrDFLIQGLGEL-------- 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 192 nqvpGIQCNPLQGAMYAFPRILIPAKAVEAAqshkmapdmfycMKLLEETGICVVPGSGFGQrEGTYHFRMTILPPVDKL 271
Cdd:PRK05942 317 ----GWNIPPTKATMYLWVPCPVGMGSTDFA------------LNVLQKTGVVVTPGNAFGE-GGEGYVRISLIADCDRL 379

                        250
                 ....*....|....
gi 568955903 272 KTVLHKVKDFHLKF 285
Cdd:PRK05942 380 GEALDRLKQAGIRY 393
PRK06836 PRK06836
pyridoxal phosphate-dependent aminotransferase;
196-263 9.55e-04

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180720  Cd Length: 394  Bit Score: 40.18  E-value: 9.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568955903 196 GIQCNPLQGAMYAFPRILIpakaveaaqshkmAPDMFYCMKLLEEtGICVVPGSGFGqREGtyHFRMT 263
Cdd:PRK06836 320 GFECVKPQGAFYLFPKSPE-------------EDDVAFCEKAKKH-NLLLVPGSGFG-CPG--YFRLS 370
PRK09276 PRK09276
LL-diaminopimelate aminotransferase; Provisional
 236-280 1.23e-03

LL-diaminopimelate aminotransferase; Provisional


Pssm-ID: 181749  Cd Length: 385  Bit Score: 39.89  E-value: 1.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568955903 236 KLLEETGICVVPGSGFGQR-EGtyHFRMTILPPVDKLKTVLHKVKD 280
Cdd:PRK09276 341 LLLDKAGVVVTPGNGFGEYgEG--YFRIALTVPDERIEEAVERIKK 384
PRK07324 PRK07324
transaminase; Validated
 171-289 3.77e-03

transaminase; Validated


Pssm-ID: 235989  Cd Length: 373  Bit Score: 38.38  E-value: 3.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568955903 171 REKEFVLGNLAkkakLTEDLFNQVPGIQCNPLQGAMYAFPRILIPAkaveaaqshkmaPDMFYCMKLLEETGICVVPGSG 250
Cdd:PRK07324 276 RNRKIVRTNLA----ILDEWVAKEPRVSYVKPKAVSTSFVKLDVDM------------PSEDFCLKLLKETGVLLVPGNR 339

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568955903 251 FGqREGtyHFRMTILPPVDKLKTVLHKVKdfhlKFLEQY 289
Cdd:PRK07324 340 FD-LEG--HVRIGYCCDTETLKKGLKKLS----EFLREF 371
PRK07366 PRK07366
LL-diaminopimelate aminotransferase;
233-281 7.05e-03

LL-diaminopimelate aminotransferase;


Pssm-ID: 180947  Cd Length: 388  Bit Score: 37.74  E-value: 7.05e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 568955903 233 YCMKLLEETGICVVPGSGFGQR-EGTYHFRMTILPPVdkLKTVLHKVKDF 281
Cdd:PRK07366 340 FCTQLVAQTGVAASPGSGFGKSgEGYVRFALVHDPDI--LEEAVERIAAF 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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