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Conserved domains on  [gi|568926008|ref|XP_006537647|]
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cadherin-17 isoform X1 [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 569-662 4.62e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 4.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 569 IFQANVSEDAAVGSRVGNVTARDP-EGL--TVSYSL-KGNMRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGS 644
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdSGEngEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 568926008 645 SLSSTADFHLVLTDVNDN 662
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-233 5.49e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 130 YEGSVRQNSRPGKPFMYVNATDLDDPatPNGQLFYQIViqlpQINDVMYFQIDSKTGAISLTpegsQELDPVKNPSYNLV 209
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIV----SGNEDGLFSIDPSTGEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....
gi 568926008 210 VSVKDMGGqseNSFSDTTYVDISI 233
Cdd:cd11304   72 VTATDGGG---PPLSSTATVTITV 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-561 1.47e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 457 TLSEDTAIGSTILIIQATDADEPFTGssKILYKIVQGDTEGRLEVvtDPTTnaGYVKIKKPLDFETQPVSSIVFQAENPE 536
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 568926008 537 PLVKgieynaSSFASFELIVTDVNE 561
Cdd:cd11304   79 GPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 244-335 3.30e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 3.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 244 VEIRENSTDPHPIkiTQVQWNDPGA------QYSLVNKEKLSPFpfSIDQE-GNIYVTQALDREEKNSHVFFATAKDENG 316
Cdd:cd11304    4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGNEDGLF--SIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 568926008 317 KPLAYPLEIYVKVIDINDN 335
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 345-443 7.51e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 7.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 345 VFEVQENEPLGNSIGIFEAHDMDEanNINSILKYKLVDQTPkvpsDGLFLIGEYEGKVQLsKQSLKKQDSPQYNLSIEVS 424
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDS--GENGEVTYSIVSGNE----DGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|..
gi 568926008 425 DVD---FKTLCYIQVNVIDIND 443
Cdd:cd11304   76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-121 8.24e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 8.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  32 PMTFSIFEGQEPSQVIFQFK------TNPPAVTFELT-GETDGIFKIEKD-GLLYHTRALDRETRAVHHLQLAALDSHGA 103
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSatdpdsGENGEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 568926008 104 IVDGPVPITIEVKDINDN 121
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 569-662 4.62e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 4.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 569 IFQANVSEDAAVGSRVGNVTARDP-EGL--TVSYSL-KGNMRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGS 644
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdSGEngEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 568926008 645 SLSSTADFHLVLTDVNDN 662
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-664 1.53e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.53e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   588 TARDP---EGLTVSYSL-KGNMRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSSLSSTADFHLVLTDVNDNP 663
Cdd:smart00112   1 SATDAdsgENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 568926008   664 P 664
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-233 5.49e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 130 YEGSVRQNSRPGKPFMYVNATDLDDPatPNGQLFYQIViqlpQINDVMYFQIDSKTGAISLTpegsQELDPVKNPSYNLV 209
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIV----SGNEDGLFSIDPSTGEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....
gi 568926008 210 VSVKDMGGqseNSFSDTTYVDISI 233
Cdd:cd11304   72 VTATDGGG---PPLSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
570-650 6.51e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 6.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  570 FQANVSEDAAVGSRVGNVTARDP-EGL--TVSYS-LKGNMRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSS 645
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPngRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                  ....*
gi 568926008  646 LSSTA 650
Cdd:pfam00028  81 LSSTA 85
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-561 1.47e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 457 TLSEDTAIGSTILIIQATDADEPFTGssKILYKIVQGDTEGRLEVvtDPTTnaGYVKIKKPLDFETQPVSSIVFQAENPE 536
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 568926008 537 PLVKgieynaSSFASFELIVTDVNE 561
Cdd:cd11304   79 GPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 244-335 3.30e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 3.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 244 VEIRENSTDPHPIkiTQVQWNDPGA------QYSLVNKEKLSPFpfSIDQE-GNIYVTQALDREEKNSHVFFATAKDENG 316
Cdd:cd11304    4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGNEDGLF--SIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 568926008 317 KPLAYPLEIYVKVIDINDN 335
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-337 7.46e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 7.46e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926008   270 YSLVNKEklSPFPFSIDQE-GNIYVTQALDREEKNSHVFFATAKDENGKPLAYPLEIYVKVIDINDNPP 337
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 345-443 7.51e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 7.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 345 VFEVQENEPLGNSIGIFEAHDMDEanNINSILKYKLVDQTPkvpsDGLFLIGEYEGKVQLsKQSLKKQDSPQYNLSIEVS 424
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDS--GENGEVTYSIVSGNE----DGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|..
gi 568926008 425 DVD---FKTLCYIQVNVIDIND 443
Cdd:cd11304   76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-121 8.24e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 8.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  32 PMTFSIFEGQEPSQVIFQFK------TNPPAVTFELT-GETDGIFKIEKD-GLLYHTRALDRETRAVHHLQLAALDSHGA 103
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSatdpdsGENGEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 568926008 104 IVDGPVPITIEVKDINDN 121
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 57-123 9.90e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 9.90e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926008    57 VTFELT-GETDGIFKIEKD-GLLYHTRALDRETRAVHHLQLAALDSHGAIVDGPVPITIEVKDINDNRP 123
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
130-233 3.66e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  130 YEGSVRQNSRPGKPFMYVNATDLDDPatPNGQLFYQIviqLPQINDVMyFQIDSKTGAISLTpegsQELDPVKNPSYNLV 209
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGN-FRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 568926008  210 VSVKDMGGQSEnsfSDTTYVDISI 233
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 148-233 1.78e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   148 NATDLDDPatPNGQLFYQIVIQlpqiNDVMYFQIDSKTGAISLTpegsQELDPVKNPSYNLVVSVKDMGGQsenSFSDTT 227
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*.
gi 568926008   228 YVDISI 233
Cdd:smart00112  68 TVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-561 3.15e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 3.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   472 QATDADEPFtgSSKILYKIVQGDTEGRLEVvtDPTTnaGYVKIKKPLDFETQPVSSIVFQAENpeplvkGIEYNASSFAS 551
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|
gi 568926008   552 FELIVTDVNE 561
Cdd:smart00112  69 VTITVLDVND 78
Cadherin pfam00028
Cadherin domain;
34-115 4.18e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 4.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   34 TFSIFEGQEPSQVIFQFKTNPP-------AVTFELTGETDGIFKIEKD-GLLYHTRALDRETRAVHHLQLAALDSHGAIV 105
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPdlgpngrIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 568926008  106 DGPVPITIEV 115
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
243-330 6.67e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 6.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  243 PVEIRENS-TDPHPIKITQVQWNDP---GAQYSLVNKEklSPFPFSIDQE-GNIYVTQALDREEKNSHVFFATAKDENGK 317
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATDPDLGpngRIFYSILGGG--PGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 568926008  318 PLAYPLEIYVKVI 330
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
457-534 7.88e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 7.88e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926008  457 TLSEDTAIGSTILIIQATDADEPftGSSKILYKIVQGDTEGRLEVVTDPttnaGYVKIKKPLDFETQPVSSIVFQAEN 534
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 363-446 1.70e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   363 AHDMDEANNINsiLKYKLVDQTPkvpsDGLFLIGEYEGKVQLSKQsLKKQDSPQYNLSIEVSDVDFKTL---CYIQVNVI 439
Cdd:smart00112   2 ATDADSGENGK--VTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITVL 74


                   ....*..
gi 568926008   440 DINDQIP 446
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
345-425 6.63e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  345 VFEVQENEPLGNSIGIFEAHDMDEANNINsiLKYKLVDQtpkvPSDGLFLIGEYEGKVQLsKQSLKKQDSPQYNLSIEVS 424
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGR--IFYSILGG----GPGGNFRIDPDTGDIST-TKPLDRESIGEYELTVEAT 74


                  .
gi 568926008  425 D 425
Cdd:pfam00028  75 D 75
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 569-662 4.62e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.78  E-value: 4.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 569 IFQANVSEDAAVGSRVGNVTARDP-EGL--TVSYSL-KGNMRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGS 644
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPdSGEngEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 568926008 645 SLSSTADFHLVLTDVNDN 662
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-664 1.53e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.55  E-value: 1.53e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   588 TARDP---EGLTVSYSL-KGNMRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSSLSSTADFHLVLTDVNDNP 663
Cdd:smart00112   1 SATDAdsgENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 568926008   664 P 664
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 130-233 5.49e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 5.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 130 YEGSVRQNSRPGKPFMYVNATDLDDPatPNGQLFYQIViqlpQINDVMYFQIDSKTGAISLTpegsQELDPVKNPSYNLV 209
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIV----SGNEDGLFSIDPSTGEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....
gi 568926008 210 VSVKDMGGqseNSFSDTTYVDISI 233
Cdd:cd11304   72 VTATDGGG---PPLSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
570-650 6.51e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 6.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  570 FQANVSEDAAVGSRVGNVTARDP-EGL--TVSYS-LKGNMRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSS 645
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPdLGPngRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                  ....*
gi 568926008  646 LSSTA 650
Cdd:pfam00028  81 LSSTA 85
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 457-561 1.47e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.73  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 457 TLSEDTAIGSTILIIQATDADEPFTGssKILYKIVQGDTEGRLEVvtDPTTnaGYVKIKKPLDFETQPVSSIVFQAENPE 536
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 568926008 537 PLVKgieynaSSFASFELIVTDVNE 561
Cdd:cd11304   79 GPPL------SSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 244-335 3.30e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 3.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 244 VEIRENSTDPHPIkiTQVQWNDPGA------QYSLVNKEKLSPFpfSIDQE-GNIYVTQALDREEKNSHVFFATAKDENG 316
Cdd:cd11304    4 VSVPENAPPGTVV--LTVSATDPDSgengevTYSIVSGNEDGLF--SIDPStGEITTAKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 568926008 317 KPLAYPLEIYVKVIDINDN 335
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 270-337 7.46e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 7.46e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926008   270 YSLVNKEklSPFPFSIDQE-GNIYVTQALDREEKNSHVFFATAKDENGKPLAYPLEIYVKVIDINDNPP 337
Cdd:smart00112  15 YSILSGN--DDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 345-443 7.51e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.11  E-value: 7.51e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 345 VFEVQENEPLGNSIGIFEAHDMDEanNINSILKYKLVDQTPkvpsDGLFLIGEYEGKVQLsKQSLKKQDSPQYNLSIEVS 424
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDS--GENGEVTYSIVSGNE----DGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|..
gi 568926008 425 DVD---FKTLCYIQVNVIDIND 443
Cdd:cd11304   76 DGGgppLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-121 8.24e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.03  E-value: 8.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  32 PMTFSIFEGQEPSQVIFQFK------TNPPAVTFELT-GETDGIFKIEKD-GLLYHTRALDRETRAVHHLQLAALDSHGA 103
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSatdpdsGENGEVTYSIVsGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                         90
                 ....*....|....*...
gi 568926008 104 IVDGPVPITIEVKDINDN 121
Cdd:cd11304   81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 57-123 9.90e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.29  E-value: 9.90e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568926008    57 VTFELT-GETDGIFKIEKD-GLLYHTRALDRETRAVHHLQLAALDSHGAIVDGPVPITIEVKDINDNRP 123
Cdd:smart00112  13 VTYSILsGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
130-233 3.66e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.09  E-value: 3.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  130 YEGSVRQNSRPGKPFMYVNATDLDDPatPNGQLFYQIviqLPQINDVMyFQIDSKTGAISLTpegsQELDPVKNPSYNLV 209
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSI---LGGGPGGN-FRIDPDTGDISTT----KPLDRESIGEYELT 70

                          90       100
                  ....*....|....*....|....
gi 568926008  210 VSVKDMGGQSEnsfSDTTYVDISI 233
Cdd:pfam00028  71 VEATDSGGPPL---SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 148-233 1.78e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 57.74  E-value: 1.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   148 NATDLDDPatPNGQLFYQIVIQlpqiNDVMYFQIDSKTGAISLTpegsQELDPVKNPSYNLVVSVKDMGGQsenSFSDTT 227
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSG----NDDGLFSIDPETGEITTT----KPLDREEQPEYTLTVEATDGGGP---PLSSTA 67


                   ....*.
gi 568926008   228 YVDISI 233
Cdd:smart00112  68 TVTITV 73
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-561 3.15e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 3.15e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   472 QATDADEPFtgSSKILYKIVQGDTEGRLEVvtDPTTnaGYVKIKKPLDFETQPVSSIVFQAENpeplvkGIEYNASSFAS 551
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATD------GGGPPLSSTAT 68

                           90
                   ....*....|
gi 568926008   552 FELIVTDVNE 561
Cdd:smart00112  69 VTITVLDVND 78
Cadherin pfam00028
Cadherin domain;
34-115 4.18e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 51.53  E-value: 4.18e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   34 TFSIFEGQEPSQVIFQFKTNPP-------AVTFELTGETDGIFKIEKD-GLLYHTRALDRETRAVHHLQLAALDSHGAIV 105
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPdlgpngrIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                          90
                  ....*....|
gi 568926008  106 DGPVPITIEV 115
Cdd:pfam00028  82 SSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
243-330 6.67e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 6.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  243 PVEIRENS-TDPHPIKITQVQWNDP---GAQYSLVNKEklSPFPFSIDQE-GNIYVTQALDREEKNSHVFFATAKDENGK 317
Cdd:pfam00028   2 SASVPENApVGTEVLTVTATDPDLGpngRIFYSILGGG--PGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 568926008  318 PLAYPLEIYVKVI 330
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
457-534 7.88e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 7.88e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568926008  457 TLSEDTAIGSTILIIQATDADEPftGSSKILYKIVQGDTEGRLEVVTDPttnaGYVKIKKPLDFETQPVSSIVFQAEN 534
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 363-446 1.70e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.27  E-value: 1.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008   363 AHDMDEANNINsiLKYKLVDQTPkvpsDGLFLIGEYEGKVQLSKQsLKKQDSPQYNLSIEVSDVDFKTL---CYIQVNVI 439
Cdd:smart00112   2 ATDADSGENGK--VTYSILSGND----DGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGPPLsstATVTITVL 74


                   ....*..
gi 568926008   440 DINDQIP 446
Cdd:smart00112  75 DVNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 34-121 4.24e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.10  E-value: 4.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  34 TFSIFEGQEPSQVIFQFKTNPPAVT---FELTGE----TDGIFKIE-KDGLLYHTRALDRETRAVHHLQLAALDSHGAIV 105
Cdd:cd00031    3 DGSAVEGRSRGSFRVSIPTDLIASSgeiIKISAAgkeaLPSWLHWEpHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                         90
                 ....*....|....*.
gi 568926008 106 DGPVPITIEVKDINDN 121
Cdd:cd00031   83 QTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
345-425 6.63e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 6.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008  345 VFEVQENEPLGNSIGIFEAHDMDEANNINsiLKYKLVDQtpkvPSDGLFLIGEYEGKVQLsKQSLKKQDSPQYNLSIEVS 424
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLGPNGR--IFYSILGG----GPGGNFRIDPDTGDIST-TKPLDRESIGEYELTVEAT 74


                  .
gi 568926008  425 D 425
Cdd:pfam00028  75 D 75
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 267-335 7.83e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 42.33  E-value: 7.83e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 267 GAQYSLVNKEKLsPFPFSIDQE-GNIYVTQALDREEKNSHVFFATAKDENGKPLAYPLEIYVKVIDINDN 335
Cdd:cd00031   30 IIKISAAGKEAL-PSWLHWEPHsGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-662 1.90e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.18  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926008 574 VSEDAAVGSRVGNVTARDPEGLTVSYSL--KGN--MRGWLKIDSVTGEIFSAAPLDRETESVYRVQVVATEVGGSSLSST 649
Cdd:cd00031    6 AVEGRSRGSFRVSIPTDLIASSGEIIKIsaAGKeaLPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTS 85

                         90
                 ....*....|...
gi 568926008 650 ADFHLVLTDVNDN 662
Cdd:cd00031   86 SVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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