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Conserved domains on  [gi|568923253|ref|XP_006501764|]
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probable ATP-dependent RNA helicase DDX20 isoform X1 [Mus musculus]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13028618)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; such as Bacillus cereus ATP-dependent RNA helicase DbpA that is involved in the assembly of the 50S ribosomal subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 74-266 2.87e-120

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 360.81  E-value: 2.87e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITA 153
Cdd:cd17943    1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 154 IGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLeEGSFQEQINWIYSS 233
Cdd:cd17943   81 IGKKLEGLKCEVFIGGTPVKEDKKKLKGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLM-EGSFQKDVNWIFSS 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568923253 234 LPASKQMLAVSATYPEVLANALTRYMRDPTFVR 266
Cdd:cd17943  160 LPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 277-414 5.34e-43

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 152.28  E-value: 5.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 277 LKQYYQVVNSyplahkifEEKTQHL-QELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAK 355
Cdd:cd18787    1 IKQLYVVVEE--------EEKKLLLlLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKK 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568923253 356 LKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYC 414
Cdd:cd18787   73 FRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
 
Name Accession Description Interval E-value
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 74-266 2.87e-120

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 360.81  E-value: 2.87e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITA 153
Cdd:cd17943    1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 154 IGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLeEGSFQEQINWIYSS 233
Cdd:cd17943   81 IGKKLEGLKCEVFIGGTPVKEDKKKLKGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLM-EGSFQKDVNWIFSS 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568923253 234 LPASKQMLAVSATYPEVLANALTRYMRDPTFVR 266
Cdd:cd17943  160 LPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
65-433 4.40e-105

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 329.80  E-value: 4.40e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFsTIALDSLILENYS--TQILILAPTRE 142
Cdd:COG0513    4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAF-LLPLLQRLDPSRPraPQALILAPTRE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 143 IAVQIHSVITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEG 221
Cdd:COG0513   83 LALQVAEELRKLA-KYLGLRVATVYGGVSIGRQIRALKRgVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 222 sFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSyplahkifEEKTQHL 301
Cdd:COG0513  162 -FIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDK--------RDKLELL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 302 QELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNL 381
Cdd:COG0513  233 RRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSH 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568923253 382 VVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRgEEENMMMKIAQKCNIN 433
Cdd:COG0513  313 VINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP-DERRLLRAIEKLIGQK 363
PTZ00424 PTZ00424
helicase 45; Provisional
 65-413 2.63e-80

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 264.00  E-value: 2.63e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:PTZ00424  30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGIKMEgLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsF 223
Cdd:PTZ00424 110 QQIQKVVLALGDYLK-VRCHACVGGTVVRDDINKLKAgVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRG-F 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 224 QEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSYplahkifEEKTQHLQE 303
Cdd:PTZ00424 188 KGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKE-------EWKFDTLCD 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 304 LFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVV 383
Cdd:PTZ00424 261 LYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVI 340

                        330       340       350
                 ....*....|....*....|....*....|
gi 568923253 384 NLDVPLDWETYMHRIGRAGRFGTLGLTVTY 413
Cdd:PTZ00424 341 NYDLPASPENYIHRIGRSGRFGRKGVAINF 370
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 277-414 5.34e-43

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 152.28  E-value: 5.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 277 LKQYYQVVNSyplahkifEEKTQHL-QELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAK 355
Cdd:cd18787    1 IKQLYVVVEE--------EEKKLLLlLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKK 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568923253 356 LKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYC 414
Cdd:cd18787   73 FRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 87-253 3.01e-42

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 151.24  E-value: 3.01e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253   87 SPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITAIGIKMeGLECHVF 166
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  167 IGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELD-YLNpgSIRLFILDEADKLLEEGsFQEQINWIYSSLPASKQMLAVSA 245
Cdd:pfam00270  80 LGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERkLLK--NLKLLVLDEAHRLLDMG-FGPDLEEILRRLPKKRQILLLSA 156


                  ....*...
gi 568923253  246 TYPEVLAN 253
Cdd:pfam00270 157 TLPRNLED 164
DEXDc smart00487
DEAD-like helicases superfamily;
78-280 1.69e-38

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 142.25  E-value: 1.69e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253    78 LRAAGFERPSPVQLKAIP-LGRCGLDLIVQAKSGTGKTCVFSTIALDSLiLENYSTQILILAPTREIAVQIHSVITAIGI 156
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPTRELAEQWAEELKKLGP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253   157 KMeGLECHVFIGGTPLSQDKTRLKK--CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQINWIYSSL 234
Cdd:smart00487  80 SL-GLKVVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG-FGDQLEKLLKLL 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 568923253   235 PASKQMLAVSATYPEVLANALTRYMRDPtfVRLNPSDPSLIGLKQY 280
Cdd:smart00487 158 PKNVQLLLLSATPPEEIENLLELFLNDP--VFIDVGFTPLEPIEQF 201
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 296-405 3.62e-28

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 109.22  E-value: 3.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  296 EKTQHLQELFSKVPFNQALVFSNLHSRAQhLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGID 375
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 568923253  376 AEKVNLVVNLDVPLDWETYMHRIGRAGRFG 405
Cdd:pfam00271  80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
324-405 1.30e-22

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 92.27  E-value: 1.30e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253   324 QHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGR 403
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80


                   ..
gi 568923253   404 FG 405
Cdd:smart00490  81 AG 82
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
301-405 5.59e-06

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 50.11  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 301 LQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGN--------MNQNQRLDAMAKLKQFHCRVLISTDLTSR 372
Cdd:COG1111  344 LKEQLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQaskegdkgLTQKEQIEILERFRAGEFNVLVATSVAEE 423

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568923253 373 GIDAEKVNLVVNLD-VPldweT---YMHRIGRAGRFG 405
Cdd:COG1111  424 GLDIPEVDLVIFYEpVP----SeirSIQRKGRTGRKR 456
PRK13766 PRK13766
Hef nuclease; Provisional
 301-403 8.41e-04

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 42.94  E-value: 8.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 301 LQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGN--------MNQNQRLDAMAKLKQFHCRVLISTDLTSR 372
Cdd:PRK13766 356 VKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQaskdgdkgMSQKEQIEILDKFRAGEFNVLVSTSVAEE 435

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568923253 373 GIDAEKVNLVVNLD-VPLdwETYM-HRIGRAGR 403
Cdd:PRK13766 436 GLDIPSVDLVIFYEpVPS--EIRSiQRKGRTGR 466
 
Name Accession Description Interval E-value
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 74-266 2.87e-120

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 360.81  E-value: 2.87e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITA 153
Cdd:cd17943    1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLDLERRHPQVLILAPTREIAVQIHDVFKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 154 IGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLeEGSFQEQINWIYSS 233
Cdd:cd17943   81 IGKKLEGLKCEVFIGGTPVKEDKKKLKGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLM-EGSFQKDVNWIFSS 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568923253 234 LPASKQMLAVSATYPEVLANALTRYMRDPTFVR 266
Cdd:cd17943  160 LPKNKQVIAFSATYPKNLDNLLARYMRKPVLVR 192
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
65-433 4.40e-105

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 329.80  E-value: 4.40e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFsTIALDSLILENYS--TQILILAPTRE 142
Cdd:COG0513    4 FADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAF-LLPLLQRLDPSRPraPQALILAPTRE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 143 IAVQIHSVITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEG 221
Cdd:COG0513   83 LALQVAEELRKLA-KYLGLRVATVYGGVSIGRQIRALKRgVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDMG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 222 sFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSyplahkifEEKTQHL 301
Cdd:COG0513  162 -FIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDK--------RDKLELL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 302 QELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNL 381
Cdd:COG0513  233 RRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSH 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568923253 382 VVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRgEEENMMMKIAQKCNIN 433
Cdd:COG0513  313 VINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP-DERRLLRAIEKLIGQK 363
PTZ00424 PTZ00424
helicase 45; Provisional
 65-413 2.63e-80

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 264.00  E-value: 2.63e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:PTZ00424  30 FDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQALILAPTRELA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGIKMEgLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsF 223
Cdd:PTZ00424 110 QQIQKVVLALGDYLK-VRCHACVGGTVVRDDINKLKAgVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEMLSRG-F 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 224 QEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSYplahkifEEKTQHLQE 303
Cdd:PTZ00424 188 KGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKE-------EWKFDTLCD 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 304 LFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVV 383
Cdd:PTZ00424 261 LYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVI 340

                        330       340       350
                 ....*....|....*....|....*....|
gi 568923253 384 NLDVPLDWETYMHRIGRAGRFGTLGLTVTY 413
Cdd:PTZ00424 341 NYDLPASPENYIHRIGRSGRFGRKGVAINF 370
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 74-266 1.30e-64

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 214.23  E-value: 1.30e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENY----STQILILAPTREIAVQIHS 149
Cdd:cd00268    1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPKkkgrGPQALVLAPTRELAMQIAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 150 VITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQIN 228
Cdd:cd00268   81 VARKLG-KGTGLKVAAIYGGAPIKKQIEALKKgPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMG-FEEDVE 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568923253 229 WIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVR 266
Cdd:cd00268  159 KILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 62-427 2.88e-61

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 214.28  E-value: 2.88e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  62 PADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTR 141
Cdd:PRK11776   3 MTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQALVLCPTR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 142 EIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEE 220
Cdd:PRK11776  83 ELADQVAKEIRRLARFIPNIKVLTLCGGVPMGPQIDSLEHgAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 221 GsFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLN-PSDPSLIGlKQYYQVVNsyplahkifEEKTQ 299
Cdd:PRK11776 163 G-FQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVEsTHDLPAIE-QRFYEVSP---------DERLP 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 300 HLQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKV 379
Cdd:PRK11776 232 ALQRLLLHHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKAL 311

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568923253 380 NLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGE-------EENMMMKIA 427
Cdd:PRK11776 312 EAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEmqranaiEDYLGRKLN 366
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 65-408 7.97e-60

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 214.71  E-value: 7.97e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:PRK11634   8 FADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLDPELKAPQILVLAPTRELA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIkqlieLDYLNPGSIRL-----FILDEADKLL 218
Cdd:PRK11634  88 VQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQgPQIVVGTPGRL-----LDHLKRGTLDLsklsgLVLDEADEML 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 219 EEGsFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSYplahkifeEKT 298
Cdd:PRK11634 163 RMG-FIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGM--------RKN 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 299 QHLQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEK 378
Cdd:PRK11634 234 EALVRFLEAEDFDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVER 313

                        330       340       350
                 ....*....|....*....|....*....|
gi 568923253 379 VNLVVNLDVPLDWETYMHRIGRAGRFGTLG 408
Cdd:PRK11634 314 ISLVVNYDIPMDSESYVHRIGRTGRAGRAG 343
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 70-263 1.96e-56

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 192.15  E-value: 1.96e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  70 LSRPVLEGLRAAGFERPSPVQLKAI-PLGRcGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIH 148
Cdd:cd17939    4 LSEDLLRGIYAYGFEKPSAIQQRAIvPIIK-GRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQALVLAPTRELAQQIQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 149 SVITAIGIKMeGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQI 227
Cdd:cd17939   83 KVVKALGDYM-GVKVHACIGGTSVREDRRKLQYgPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRG-FKDQI 160

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 568923253 228 NWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPT 263
Cdd:cd17939  161 YDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 65-262 1.39e-53

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 184.57  E-value: 1.39e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:cd18046    1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQIDTSLKATQALVLAPTRELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGIKMeGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsF 223
Cdd:cd18046   81 QQIQKVVMALGDYM-GIKCHACIGGTSVRDDAQKLQAgPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRG-F 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568923253 224 QEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDP 262
Cdd:cd18046  159 KDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDP 197
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 65-262 3.69e-50

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 174.79  E-value: 3.69e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:cd17940    1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKIDPKKDVIQALILVPTRELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGiKMEGLECHVFIGGTPLSQDKTRLK-KCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLeEGSF 223
Cdd:cd17940   81 LQTSQVCKELG-KHMGVKVMVTTGGTSLRDDIMRLYqTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLL-SQDF 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568923253 224 QEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDP 262
Cdd:cd17940  159 QPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNP 197
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 64-408 5.50e-48

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 176.29  E-value: 5.50e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  64 DFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLIleNY------STQILIL 137
Cdd:PRK11192   2 TFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLL--DFprrksgPPRILIL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 138 APTREIAVQIHSVITAIGiKMEGLECHVFIGGTPLSQDKTRLKKCH-IAVGSPGRIKQLIELDYLNPGSIRLFILDEADK 216
Cdd:PRK11192  80 TPTRELAMQVADQARELA-KHTHLDIATITGGVAYMNHAEVFSENQdIVVATPGRLLQYIKEENFDCRAVETLILDEADR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 217 LLEEGsFQEQINWIYSSLPASKQMLAVSATypeVLANALTRYMR----DPTFVRLNPSDPSLIGLKQYYQVVNSYplahk 292
Cdd:PRK11192 159 MLDMG-FAQDIETIAAETRWRKQTLLFSAT---LEGDAVQDFAErllnDPVEVEAEPSRRERKKIHQWYYRADDL----- 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 293 ifEEKTQHLQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSR 372
Cdd:PRK11192 230 --EHKTALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAAR 307

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 568923253 373 GIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLG 408
Cdd:PRK11192 308 GIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKG 343
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 65-262 1.50e-46

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 164.95  E-value: 1.50e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAI-PLGRcGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREI 143
Cdd:cd18045    1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIkPIIK-GRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILSPTREL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 144 AVQIHSVITAIGIKMeGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGs 222
Cdd:cd18045   80 AVQIQKVLLALGDYM-NVQCHACIGGTSVGDDIRKLDYgQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKG- 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 568923253 223 FQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDP 262
Cdd:cd18045  158 FKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDP 197
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 65-263 9.01e-46

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 162.90  E-value: 9.01e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:cd17950    4 FRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVSVLVICHTRELA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK--CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGS 222
Cdd:cd17950   84 FQISNEYERFSKYMPNVKTAVFFGGVPIKKDIEVLKNkcPHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMLEQLD 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568923253 223 FQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPT 263
Cdd:cd17950  164 MRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPL 204
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 18-413 9.89e-46

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 170.86  E-value: 9.89e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  18 TMAAERAAAPVQAVEPTPASPWTQRTAHDIggPRTRTGDVVLaEPAD----FESLLLSRPVLEGLRAAGFERPSPVQLKA 93
Cdd:PRK01297  41 TKAAAPAAAAPRAEKPKKDKPRRERKPKPA--SLWKLEDFVV-EPQEgktrFHDFNLAPELMHAIHDLGFPYCTPIQAQV 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  94 IPLGRCGLDLIVQAKSGTGKTCVFsTIALDSLILEN------Y--STQILILAPTREIAVQIHSVITAIgIKMEGLECHV 165
Cdd:PRK01297 118 LGYTLAGHDAIGRAQTGTGKTAAF-LISIINQLLQTpppkerYmgEPRALIIAPTRELVVQIAKDAAAL-TKYTGLNVMT 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 166 FIGGTPLSQDKTRL--KKCHIAVGSPGRIkqlieLDYLNPGSIRL-----FILDEADKLLEEGsFQEQINWIYSSLP--A 236
Cdd:PRK01297 196 FVGGMDFDKQLKQLeaRFCDILVATPGRL-----LDFNQRGEVHLdmvevMVLDEADRMLDMG-FIPQVRQIIRQTPrkE 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 237 SKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSyplahkifEEKTQHLQELFSKVPFNQALVF 316
Cdd:PRK01297 270 ERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAG--------SDKYKLLYNLVTQNPWERVMVF 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 317 SNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMH 396
Cdd:PRK01297 342 ANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVH 421

                        410
                 ....*....|....*..
gi 568923253 397 RIGRAGRFGTLGLTVTY 413
Cdd:PRK01297 422 RIGRTGRAGASGVSISF 438
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 65-418 1.09e-43

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 164.60  E-value: 1.09e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQ------ILILA 138
Cdd:PRK10590   3 FDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKgrrpvrALILT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 139 PTREIAVQIHSVITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKL 217
Cdd:PRK10590  83 PTRELAAQIGENVRDYS-KYLNIRSLVVFGGVSINPQMMKLRGgVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 218 LEEGsFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLNPSDPSLIGLKQYYQVVNSyplahkifEEK 297
Cdd:PRK10590 162 LDMG-FIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDK--------KRK 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 298 TQHLQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAE 377
Cdd:PRK10590 233 RELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIE 312

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 568923253 378 KVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGE 418
Cdd:PRK10590 313 ELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALSLVCVDE 353
PTZ00110 PTZ00110
helicase; Provisional
 65-413 4.60e-43

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 164.95  E-value: 4.60e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVF---STIALDSLILENYSTQ--ILILAP 139
Cdd:PTZ00110 132 FEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFllpAIVHINAQPLLRYGDGpiVLVLAP 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 140 TREIAVQIHSVITAIGIKMEgLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLL 218
Cdd:PTZ00110 212 TRELAEQIREQCNKFGASSK-IRNTVAYGGVPKRGQIYALRRgVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRML 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 219 EEGsFQEQINWIYSSLPASKQMLAVSATYP-EV--LANALTRymRDPTFVRLNPSD-PSLIGLKQYYQVVNSYplahkif 294
Cdd:PTZ00110 291 DMG-FEPQIRKIVSQIRPDRQTLMWSATWPkEVqsLARDLCK--EEPVHVNVGSLDlTACHNIKQEVFVVEEH------- 360

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 295 eEKTQHLQELFSKV--PFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSR 372
Cdd:PTZ00110 361 -EKRGKLKMLLQRImrDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASR 439

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 568923253 373 GIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTY 413
Cdd:PTZ00110 440 GLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTF 480
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 277-414 5.34e-43

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 152.28  E-value: 5.34e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 277 LKQYYQVVNSyplahkifEEKTQHL-QELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAK 355
Cdd:cd18787    1 IKQLYVVVEE--------EEKKLLLlLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKK 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568923253 356 LKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYC 414
Cdd:cd18787   73 FRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 87-253 3.01e-42

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 151.24  E-value: 3.01e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253   87 SPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITAIGIKMeGLECHVF 166
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQALVLAPTRELAEQIYEELKKLGKGL-GLKVASL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  167 IGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELD-YLNpgSIRLFILDEADKLLEEGsFQEQINWIYSSLPASKQMLAVSA 245
Cdd:pfam00270  80 LGGDSRKEQLEKLKGPDILVGTPGRLLDLLQERkLLK--NLKLLVLDEAHRLLDMG-FGPDLEEILRRLPKKRQILLLSA 156


                  ....*...
gi 568923253  246 TYPEVLAN 253
Cdd:pfam00270 157 TLPRNLED 164
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 70-266 4.54e-41

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 149.26  E-value: 4.54e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  70 LSRPVLEGLRAAGFERPSPVQLKAIP--LGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQI 147
Cdd:cd17963    1 LKPELLKGLYAMGFNKPSKIQETALPliLSDPPENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQALCLAPTRELARQI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 148 HSVITAIGiKMEGLECHVFIGGTPLSQDKTrlKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQI 227
Cdd:cd17963   81 GEVVEKMG-KFTGVKVALAVPGNDVPRGKK--ITAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTQGHGDQS 157

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568923253 228 NWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVR 266
Cdd:cd17963  158 IRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 65-415 6.13e-40

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 155.88  E-value: 6.13e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLI----LENYSTQ---ILIL 137
Cdd:PRK04537  11 FSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLsrpaLADRKPEdprALIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 138 APTREIAVQIHSVITAIGIKMeGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIkqlieLDYLNPGSI------RLFI 210
Cdd:PRK04537  91 APTRELAIQIHKDAVKFGADL-GLRFALVYGGVDYDKQRELLQQgVDVIIATPGRL-----IDYVKQHKVvslhacEICV 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 211 LDEADKLLEEGsFQEQINWIYSSLP--ASKQMLAVSATYPEVLANALTRYMRDPTfvrlnpsdpsliGLKQYYQVVNSYP 288
Cdd:PRK04537 165 LDEADRMFDLG-FIKDIRFLLRRMPerGTRQTLLFSATLSHRVLELAYEHMNEPE------------KLVVETETITAAR 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 289 LAHKIF----EEKTQHLQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVL 364
Cdd:PRK04537 232 VRQRIYfpadEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEIL 311

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568923253 365 ISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCC 415
Cdd:PRK04537 312 VATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFAC 362
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 65-419 8.02e-40

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 152.43  E-value: 8.02e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLIL-----ENYSTQ--ILIL 137
Cdd:PRK04837  10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLShpapeDRKVNQprALIM 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 138 APTREIAVQIHSVITAIgIKMEGLECHVFIGGTplSQDKTRL---KKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEA 214
Cdd:PRK04837  90 APTRELAVQIHADAEPL-AQATGLKLGLAYGGD--GYDKQLKvleSGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 215 DKLLEEGsFQEQINWIYSSLPASKQMLAV--SATYPEVLANALTRYMRDPTFVRLNPsdpsliglkqyyqvvnsyplahk 292
Cdd:PRK04837 167 DRMFDLG-FIKDIRWLFRRMPPANQRLNMlfSATLSYRVRELAFEHMNNPEYVEVEP----------------------- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 293 ifEEKTQHL--QELFskVPFNQ-----------------ALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAM 353
Cdd:PRK04837 223 --EQKTGHRikEELF--YPSNEekmrllqtlieeewpdrAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRIL 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568923253 354 AKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCrgEE 419
Cdd:PRK04837 299 EEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLAC--EE 362
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 65-266 1.56e-39

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 145.14  E-value: 1.56e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFstiaLDSLI--LENYSTQI----LILA 138
Cdd:cd17959    3 FQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAF----LIPMIekLKAHSPTVgaraLILS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 139 PTREIAVQIHSVITAIGiKMEGLECHVFIGGTPLSQDKTRLKKC-HIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKL 217
Cdd:cd17959   79 PTRELALQTLKVTKELG-KFTDLRTALLVGGDSLEEQFEALASNpDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568923253 218 LEEGsFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVR 266
Cdd:cd17959  158 FEMG-FAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLIR 205
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 65-264 1.06e-38

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 142.75  E-value: 1.06e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:cd17955    1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRLSEDPYGIFALVLTPTRELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGIKMeGLECHVFIGGTPLSQDKTRLKKC-HIAVGSPGRIKQLIELDYLNPGS---IRLFILDEADKLLeE 220
Cdd:cd17955   81 YQIAEQFRALGAPL-GLRCCVIVGGMDMVKQALELSKRpHIVVATPGRLADHLRSSDDTTKVlsrVKFLVLDEADRLL-T 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 568923253 221 GSFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTF 264
Cdd:cd17955  159 GSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFF 202
DEXDc smart00487
DEAD-like helicases superfamily;
78-280 1.69e-38

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 142.25  E-value: 1.69e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253    78 LRAAGFERPSPVQLKAIP-LGRCGLDLIVQAKSGTGKTCVFSTIALDSLiLENYSTQILILAPTREIAVQIHSVITAIGI 156
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEAL-KRGKGGRVLVLVPTRELAEQWAEELKKLGP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253   157 KMeGLECHVFIGGTPLSQDKTRLKK--CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQINWIYSSL 234
Cdd:smart00487  80 SL-GLKVVGLYGGDSKREQLRKLESgkTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGG-FGDQLEKLLKLL 157

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 568923253   235 PASKQMLAVSATYPEVLANALTRYMRDPtfVRLNPSDPSLIGLKQY 280
Cdd:smart00487 158 PKNVQLLLLSATPPEEIENLLELFLNDP--VFIDVGFTPLEPIEQF 201
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 75-268 2.36e-38

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 141.66  E-value: 2.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  75 LEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQ----ILILAPTREIAVQIHSV 150
Cdd:cd17941    2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEdglgALIISPTRELAMQIFEV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 151 ITAIGiKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQ-LIELDYLNPGSIRLFILDEADKLLEEGsFQEQINW 229
Cdd:cd17941   82 LRKVG-KYHSFSAGLIIGGKDVKEEKERINRMNILVCTPGRLLQhMDETPGFDTSNLQMLVLDEADRILDMG-FKETLDA 159

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568923253 230 IYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRLN 268
Cdd:cd17941  160 IVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISVH 198
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 70-249 4.18e-36

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 135.40  E-value: 4.18e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  70 LSRPVLEGLRAAGFERPSPVQLKAI-PLGRCGLDLIVQAKSGTGKTCVFSTIALDSLI-----LENYSTQILILAPTREI 143
Cdd:cd17964    1 LDPSLLKALTRMGFETMTPVQQKTLkPILSTGDDVLARAKTGTGKTLAFLLPAIQSLLntkpaGRRSGVSALIISPTREL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 144 AVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKK--CHIAVGSPGRIKQLIEldylNPGS------IRLFILDEAD 215
Cdd:cd17964   81 ALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRRgrPDILVATPGRLIDHLE----NPGVakaftdLDYLVLDEAD 156

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568923253 216 KLLEEGsFQEQINWIYSSLPASK----QMLAVSATYPE 249
Cdd:cd17964  157 RLLDMG-FRPDLEQILRHLPEKNadprQTLLFSATVPD 193
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 55-413 1.59e-35

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 141.85  E-value: 1.59e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  55 GDVVLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVF--STIALDSLILENYST 132
Cdd:PLN00206 113 GEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFlvPIISRCCTIRSGHPS 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 133 Q-----ILILAPTREIAVQIHSVITAIGikmEGL--ECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRI-----KQLIELD 199
Cdd:PLN00206 193 EqrnplAMVLTPTRELCVQVEDQAKVLG---KGLpfKTALVVGGDAMPQQLYRIQQgVELIVGTPGRLidllsKHDIELD 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 200 YlnpgsIRLFILDEADKLLEEGsFQEQINWIYSSLPaSKQMLAVSATYPEVLANALTRYMRDPTFVRL-NPSDPSliglK 278
Cdd:PLN00206 270 N-----VSVLVLDEVDCMLERG-FRDQVMQIFQALS-QPQVLLFSATVSPEVEKFASSLAKDIILISIgNPNRPN----K 338

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 279 QYYQVVnsyplahkIFEEKTQHLQELF----SKVPFN-QALVFSNLHSRAQHLAD-ILSSKGFPTECISGNMNQNQRLDA 352
Cdd:PLN00206 339 AVKQLA--------IWVETKQKKQKLFdilkSKQHFKpPAVVFVSSRLGADLLANaITVVTGLKALSIHGEKSMKERREV 410

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568923253 353 MAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTY 413
Cdd:PLN00206 411 MKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVF 471
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 74-246 4.74e-35

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 131.99  E-value: 4.74e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLIL---ENYSTQILILAPTREIAVQIHSV 150
Cdd:cd17947    1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYrpkKKAATRVLVLVPTRELAMQCFSV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 151 ITAIGiKMEGLECHVFIGGTPLSQDKTRLKKC-HIAVGSPGRIkqlieLDYL-NPGSIRL-----FILDEADKLLEEGsF 223
Cdd:cd17947   81 LQQLA-QFTDITFALAVGGLSLKAQEAALRARpDIVIATPGRL-----IDHLrNSPSFDLdsieiLVLDEADRMLEEG-F 153

                        170       180
                 ....*....|....*....|...
gi 568923253 224 QEQINWIYSSLPASKQMLAVSAT 246
Cdd:cd17947  154 ADELKEILRLCPRTRQTMLFSAT 176
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 65-265 2.51e-33

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 127.99  E-value: 2.51e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYST----------QI 134
Cdd:cd17967    2 FEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSvgrgrrkaypSA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 135 LILAPTREIAVQIHsvitaigikME--------GLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGS 205
Cdd:cd17967   82 LILAPTRELAIQIY---------EEarkfsyrsGVRSVVVYGGADVVHQQLQLLRgCDILVATPGRLVDFIERGRISLSS 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568923253 206 IRLFILDEADKLLEEGsFQEQINWI--YSSLP--ASKQMLAVSATYPEVLANALTRYMRDPTFV 265
Cdd:cd17967  153 IKFLVLDEADRMLDMG-FEPQIRKIveHPDMPpkGERQTLMFSATFPREIQRLAADFLKNYIFL 215
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 74-239 2.07e-32

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 124.61  E-value: 2.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDslILENYSTQI-------LILAPTREIAVQ 146
Cdd:cd17960    1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLE--ILLKRKANLkkgqvgaLIISPTRELATQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 147 IHSVITAIgIKMEGLE--CHVFIGGT-PLSQDKTRL-KKCHIAVGSPGRIKQLIEL--DYLNPGSIRLFILDEADKLLEE 220
Cdd:cd17960   79 IYEVLQSF-LEHHLPKlkCQLLIGGTnVEEDVKKFKrNGPNILVGTPGRLEELLSRkaDKVKVKSLEVLVLDEADRLLDL 157

                        170
                 ....*....|....*....
gi 568923253 221 GsFQEQINWIYSSLPasKQ 239
Cdd:cd17960  158 G-FEADLNRILSKLP--KQ 173
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 65-246 2.44e-32

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 124.35  E-value: 2.44e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIA 144
Cdd:cd17954    2 FKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRFFALVLAPTRELA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 145 VQIHSVITAIGIKMeGLECHVFIGG-TPLSQDKTRLKKCHIAVGSPGRIkqlieLDYL------NPGSIRLFILDEADKL 217
Cdd:cd17954   82 QQISEQFEALGSSI-GLKSAVLVGGmDMMAQAIALAKKPHVIVATPGRL-----VDHLentkgfSLKSLKFLVMDEADRL 155

                        170       180
                 ....*....|....*....|....*....
gi 568923253 218 LEEgSFQEQINWIYSSLPASKQMLAVSAT 246
Cdd:cd17954  156 LNM-DFEPEIDKILKVIPRERTTYLFSAT 183
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 65-265 6.81e-32

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 123.20  E-value: 6.81e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALdslilenystQI---LILAPTR 141
Cdd:cd17938    1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL----------QIvvaLILEPSR 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 142 EIAVQIHSVITAIGIKMEG--LECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLL 218
Cdd:cd17938   71 ELAEQTYNCIENFKKYLDNpkLRVALLIGGVKAREQLKRLESgVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLL 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568923253 219 EEGSfQEQINWIYSSLPASK------QMLAVSATY--PEV--LANALtryMRDPTFV 265
Cdd:cd17938  151 SQGN-LETINRIYNRIPKITsdgkrlQVIVCSATLhsFEVkkLADKI---MHFPTWV 203
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 78-255 1.33e-31

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 121.89  E-value: 1.33e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  78 LRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTREIAVQIHSVITAIGIK 157
Cdd:cd17962    5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVIIRCLTEHRNPSALILTPTRELAVQIEDQAKELMKG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 158 MEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQINWIYSSLPA 236
Cdd:cd17962   85 LPPMKTALLVGGLPLPPQLYRLQQgVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMG-FQQQVLDILENISH 163

                        170       180
                 ....*....|....*....|..
gi 568923253 237 SKQMLAVSATYP---EVLANAL 255
Cdd:cd17962  164 DHQTILVSATIPrgiEQLAGQL 185
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 74-267 1.09e-30

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 119.62  E-value: 1.09e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLIL--ENYSTQILILAPTREIAVQIHSVI 151
Cdd:cd17957    1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKprKKKGLRALILAPTRELASQIYREL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 152 TAIGiKMEGLECHVFIGGTPLSQDKTR--LKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQINW 229
Cdd:cd17957   81 LKLS-KGTGLRIVLLSKSLEAKAKDGPksITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPG-FREQTDE 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568923253 230 IYSSLPA-SKQMLAVSATYPEVLANALTRYMRDPtfVRL 267
Cdd:cd17957  159 ILAACTNpNLQRSLFSATIPSEVEELARSVMKDP--IRI 195
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 74-265 1.28e-30

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 120.12  E-value: 1.28e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFST---IALDSL-ILENYSTQ----ILILAPTREIAV 145
Cdd:cd17945    1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIpllVYISRLpPLDEETKDdgpyALILAPTRELAQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 146 QIHSVITAIGIKMeGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQ 224
Cdd:cd17945   81 QIEEETQKFAKPL-GIRVVSIVGGHSIEEQAFSLRNgCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMG-FE 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568923253 225 EQINWIYSSLPAS--------------------KQMLAVSATYPEVLANALTRYMRDPTFV 265
Cdd:cd17945  159 PQVTKILDAMPVSnkkpdteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 65-249 1.31e-29

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 118.53  E-value: 1.31e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLI---------LENYSTQIL 135
Cdd:cd18052   45 FEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMkegltassfSEVQEPQAL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 136 ILAPTREIAVQIHsvitaigikmegLECHVFIGGTPLS------------QDKTRLKKCHIAVGSPGRIKQLIELDYLNP 203
Cdd:cd18052  125 IVAPTRELANQIF------------LEARKFSYGTCIRpvvvyggvsvghQIRQIEKGCHILVATPGRLLDFIGRGKISL 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 568923253 204 GSIRLFILDEADKLLEEGsFQEQINWI--YSSLPA--SKQMLAVSATYPE 249
Cdd:cd18052  193 SKLKYLILDEADRMLDMG-FGPEIRKLvsEPGMPSkeDRQTLMFSATFPE 241
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 296-405 3.62e-28

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 109.22  E-value: 3.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  296 EKTQHLQELFSKVPFNQALVFSNLHSRAQhLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGID 375
Cdd:pfam00271   1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 568923253  376 AEKVNLVVNLDVPLDWETYMHRIGRAGRFG 405
Cdd:pfam00271  80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 82-266 4.05e-28

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 112.68  E-value: 4.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  82 GFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVF------STIALDSLILENYSTQILILAPTREIAVQIHSVITAIG 155
Cdd:cd17949   10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYllpiiqRLLSLEPRVDRSDGTLALVLVPTRELALQIYEVLEKLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 156 IKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIkqlieLDYL------NPGSIRLFILDEADKLLEEGsFQEQIN 228
Cdd:cd17949   90 KPFHWIVPGYLIGGEKRKSEKARLRKgVNILIATPGRL-----LDHLkntqsfDVSNLRWLVLDEADRLLDMG-FEKDIT 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568923253 229 WIYS-------------SLPASKQMLAVSATYP---EVLANALtryMRDPTFVR 266
Cdd:cd17949  164 KILEllddkrskaggekSKPSRRQTVLVSATLTdgvKRLAGLS---LKDPVYID 214
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 74-265 4.22e-28

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 112.43  E-value: 4.22e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQI--------LILAPTREIAV 145
Cdd:cd17951    1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQEKKLPFikgegpygLIVCPSRELAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 146 QIHSVITAIGIKME-----GLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLE 219
Cdd:cd17951   81 QTHEVIEYYCKALQeggypQLRCLLCIGGMSVKEQLEVIRKgVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMID 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568923253 220 EGsFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFV 265
Cdd:cd17951  161 MG-FEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 74-265 5.49e-28

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 111.79  E-value: 5.49e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQ------ILILAPTREIAVQI 147
Cdd:cd17958    1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREqrngpgVLVLTPTRELALQI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 148 HSVITAIGIKMEGLEChVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQI 227
Cdd:cd17958   81 EAECSKYSYKGLKSVC-VYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMG-FEPQI 158

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568923253 228 NWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFV 265
Cdd:cd17958  159 RKILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 74-265 3.55e-27

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 109.38  E-value: 3.55e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQ-----ILILAPTREIAVQIH 148
Cdd:cd17966    1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERgdgpiVLVLAPTRELAQQIQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 149 SVITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIkqlieLDYLNPGSIRL-----FILDEADKLLEEGs 222
Cdd:cd17966   81 QEANKFG-GSSRLRNTCVYGGAPKGPQIRDLRRgVEICIATPGRL-----IDFLDQGKTNLrrvtyLVLDEADRMLDMG- 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 568923253 223 FQEQINWIYSSLPASKQMLAVSATYP-EVLANALTrYMRDPTFV 265
Cdd:cd17966  154 FEPQIRKIVDQIRPDRQTLMWSATWPkEVRRLAED-FLKDYIQV 196
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 68-262 6.86e-27

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 109.39  E-value: 6.86e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  68 LLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIAL----DSLILENYSTQI-LILAPTRE 142
Cdd:cd17953   17 CGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFrhikDQRPVKPGEGPIgLIMAPTRE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 143 IAVQIHSVITAIgIKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRikqLIELDYLNPGSI------RLFILDEAD 215
Cdd:cd17953   97 LALQIYVECKKF-SKALGLRVVCVYGGSGISEQIAELKRgAEIVVCTPGR---MIDILTANNGRVtnlrrvTYVVLDEAD 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568923253 216 KLLEEGsFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDP 262
Cdd:cd17953  173 RMFDMG-FEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKP 218
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 74-312 2.49e-26

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 108.10  E-value: 2.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLG-RCGLDLIVQAKSGTGKTCVFStIALDSLILENYSTQI----------LILAPTRE 142
Cdd:cd17946    1 ILRALADLGFSEPTPIQALALPAAiRDGKDVIGAAETGSGKTLAFG-IPILERLLSQKSSNGvggkqkplraLILTPTRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 143 IAVQIHSVITAIgIKMEGLECHVFIGGtpLSQDKT-RL--KKCHIAVGSPGRIKQLIELDylNPG-----SIRLFILDEA 214
Cdd:cd17946   80 LAVQVKDHLKAI-AKYTNIKIASIVGG--LAVQKQeRLlkKRPEIVVATPGRLWELIQEG--NEHlanlkSLRFLVLDEA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 215 DKLLEEGSFQE--QI-NWIYSSLPASK---QMLAVSATypevlanaLTrymrdptfvrLNPSDPSLIGLKQyyqvvnsyp 288
Cdd:cd17946  155 DRMLEKGHFAEleKIlELLNKDRAGKKrkrQTFVFSAT--------LT----------LDHQLPLKLNSKK--------- 207

                        250       260
                 ....*....|....*....|....
gi 568923253 289 laHKIFEEKTQHLQELFSKVPFNQ 312
Cdd:cd17946  208 --KKKKKEKKQKLELLIEKVGFRK 229
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 65-267 5.97e-26

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 107.03  E-value: 5.97e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIP--LGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTRE 142
Cdd:cd18048   20 FEELHLKEELLRGIYAMGFNRPSKIQENALPmmLADPPQNLIAQSQSGTGKTAAFVLAMLSRVDALKLYPQCLCLSPTFE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 143 IAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDkTRLKKcHIAVGSPGRI-KQLIELDYLNPGSIRLFILDEADKLLEEG 221
Cdd:cd18048  100 LALQTGKVVEEMGKFCVGIQVIYAIRGNRPGKG-TDIEA-QIVIGTPGTVlDWCFKLRLIDVTNISVFVLDEADVMINVQ 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568923253 222 SFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVRL 267
Cdd:cd18048  178 GHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNIIKL 223
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 70-246 7.44e-25

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 103.05  E-value: 7.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  70 LSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFStIALDSLIL-------ENYSTQILILAPTRE 142
Cdd:cd17961    1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYA-LPIIQKILkakaesgEEQGTRALILVPTRE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 143 IAVQIHSVITAIGIKMEG-LECHVFIGGTPLSQDKTRLK-KCHIAVGSPGRIKQLIELDYL-NPGSIRLFILDEADKLLE 219
Cdd:cd17961   80 LAQQVSKVLEQLTAYCRKdVRVVNLSASSSDSVQRALLAeKPDIVVSTPARLLSHLESGSLlLLSTLKYLVIDEADLVLS 159

                        170       180
                 ....*....|....*....|....*..
gi 568923253 220 EGsFQEQINWIYSSLPASKQMLAVSAT 246
Cdd:cd17961  160 YG-YEEDLKSLLSYLPKNYQTFLMSAT 185
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 75-246 6.42e-24

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 100.13  E-value: 6.42e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  75 LEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENY----STQILILAPTREIAVQIHSV 150
Cdd:cd17942    2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFkprnGTGVIIISPTRELALQIYGV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 151 ITAIgIKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIkqlieLDYL--NPG----SIRLFILDEADKLLEEGsF 223
Cdd:cd17942   82 AKEL-LKYHSQTFGIVIGGANRKAEAEKLGKgVNILVATPGRL-----LDHLqnTKGflykNLQCLIIDEADRILEIG-F 154

                        170       180
                 ....*....|....*....|...
gi 568923253 224 QEQINWIYSSLPASKQMLAVSAT 246
Cdd:cd17942  155 EEEMRQIIKLLPKRRQTMLFSAT 177
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 74-248 7.89e-24

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 99.80  E-value: 7.89e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIAL----DSLILENYSTQI-LILAPTREIAVQIH 148
Cdd:cd17952    1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLvhimDQRELEKGEGPIaVIVAPTRELAQQIY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 149 SVITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQI 227
Cdd:cd17952   81 LEAKKFG-KAYNLRVVAVYGGGSKWEQAKALQEgAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMG-FEYQV 158

                        170       180
                 ....*....|....*....|.
gi 568923253 228 NWIYSSLPASKQMLAVSATYP 248
Cdd:cd17952  159 RSIVGHVRPDRQTLLFSATFK 179
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 78-260 2.30e-23

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 98.77  E-value: 2.30e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  78 LRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSL------ILENYSTQILILAPTREIAVQIHSVI 151
Cdd:cd17944    5 LQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLqedqqpRKRGRAPKVLVLAPTRELANQVTKDF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 152 TAIGIKmegLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQINWI 230
Cdd:cd17944   85 KDITRK---LSVACFYGGTPYQQQIFAIRNgIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMG-FAEQVEEI 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568923253 231 ----YSSLPASK-QMLAVSATYPEVLANALTRYMR 260
Cdd:cd17944  161 lsvsYKKDSEDNpQTLLFSATCPDWVYNVAKKYMK 195
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 65-266 7.93e-23

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 97.10  E-value: 7.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  65 FESLLLSRPVLEGLRAAGFERPSPVQLKAIP--LGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQILILAPTRE 142
Cdd:cd18047    3 FEELRLKPQLLQGVYAMGFNRPSKIQENALPlmLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 143 IAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDkTRLKKcHIAVGSPGRI-KQLIELDYLNPGSIRLFILDEADKLLEEG 221
Cdd:cd18047   83 LALQTGKVIEQMGKFYPELKLAYAVRGNKLERG-QKISE-QIVIGTPGTVlDWCSKLKFIDPKKIKVFVLDEADVMIATQ 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 568923253 222 SFQEQINWIYSSLPASKQMLAVSATYPEVLANALTRYMRDPTFVR 266
Cdd:cd18047  161 GHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
HELICc smart00490
helicase superfamily c-terminal domain;
324-405 1.30e-22

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 92.27  E-value: 1.30e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253   324 QHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGR 403
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80


                   ..
gi 568923253   404 FG 405
Cdd:smart00490  81 AG 82
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 46-248 2.18e-22

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 97.03  E-value: 2.18e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  46 DIggPRTRTGDVVLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFsTIALDSL 125
Cdd:cd18051    6 DI--PVEATGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAF-LLPILSQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 126 ILEN------------YSTQ-----ILILAPTREIAVQIHSVITAIGIKMEGLECHVFiGGTPLSQDKTRLKK-CHIAVG 187
Cdd:cd18051   83 IYEQgpgeslpsesgyYGRRkqyplALVLAPTRELASQIYDEARKFAYRSRVRPCVVY-GGADIGQQMRDLERgCHLLVA 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 188 SPGRIKQLIE-----LDYlnpgsIRLFILDEADKLLEEGsFQEQINWIYS--SLPAS--KQMLAVSATYP 248
Cdd:cd18051  162 TPGRLVDMLErgkigLDY-----CKYLVLDEADRMLDMG-FEPQIRRIVEqdTMPPTgeRQTLMFSATFP 225
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 74-268 1.42e-19

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 88.53  E-value: 1.42e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSL----ILENYSTQI-LILAPTREIAVQIH 148
Cdd:cd18049   35 VMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHInhqpFLERGDGPIcLVLAPTRELAQQVQ 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 149 SVITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQI 227
Cdd:cd18049  115 QVAAEYG-RACRLKSTCIYGGAPKGPQIRDLERgVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMG-FEPQI 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568923253 228 NWIYSSLPASKQMLAVSATYPEVLANALTRYMRDptFVRLN 268
Cdd:cd18049  193 RKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKD--YIHIN 231
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 74-268 2.00e-19

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 89.30  E-value: 2.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLILENYSTQ-----ILILAPTREIAVQIH 148
Cdd:cd18050   73 VMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERgdgpiCLVLAPTRELAQQVQ 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 149 SVITAIGiKMEGLECHVFIGGTPLSQDKTRLKK-CHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGsFQEQI 227
Cdd:cd18050  153 QVADDYG-KSSRLKSTCIYGGAPKGPQIRDLERgVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMG-FEPQI 230

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568923253 228 NWIYSSLPASKQMLAVSATYPEVLANALTRYMRDptFVRLN 268
Cdd:cd18050  231 RKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRD--YVQIN 269
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 74-257 5.56e-14

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 72.01  E-value: 5.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLI--LENYSTQI-----LILAPTREIAVQ 146
Cdd:cd17948    1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLryKLLAEGPFnaprgLVITPSRELAEQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 147 IHSVITAIGIKMeGLECHVFIGGtplsQDKTRLKKCH-----IAVGSPGRI-----KQLIELDYLnpgsiRLFILDEADK 216
Cdd:cd17948   81 IGSVAQSLTEGL-GLKVKVITGG----RTKRQIRNPHfeevdILVATPGALsklltSRIYSLEQL-----RHLVLDEADT 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568923253 217 LLEEgSFQEQINWIYSSLPASK-------------QMLAVSATYPEVLANALTR 257
Cdd:cd17948  151 LLDD-SFNEKLSHFLRRFPLASrrsentdgldpgtQLVLVSATMPSGVGEVLSK 203
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 74-229 2.38e-11

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 64.58  E-value: 2.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  74 VLEGLRAAGFERPSPVQLKAIPL----GRCGL-----DLIVQAKSGTGKTCVFstiALDslILENYSTQI------LILA 138
Cdd:cd17956    1 LLKNLQNNGITSAFPVQAAVIPWllpsSKSTPpyrpgDLCVSAPTGSGKTLAY---VLP--IVQALSKRVvprlraLIVV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 139 PTREIAVQIHSV----ITAIGIKMeGLEC--HVFIGGTPLSQDKTR---LKKCHIAVGSPGRIkqlieLDYLN--PG--- 204
Cdd:cd17956   76 PTKELVQQVYKVfeslCKGTGLKV-VSLSgqKSFKKEQKLLLVDTSgryLSRVDILVATPGRL-----VDHLNstPGftl 149

                        170       180
                 ....*....|....*....|....*.
gi 568923253 205 -SIRLFILDEADKLLEEgSFQeqiNW 229
Cdd:cd17956  150 kHLRFLVIDEADRLLNQ-SFQ---DW 171
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 86-267 6.26e-11

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 63.55  E-value: 6.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253  86 PSPVQLKAIP------LGRCGLDLI----------VQAKSGTGKTCVFSTIALDSLILENYST----------------- 132
Cdd:cd17965   31 PSPIQTLAIKkllktlMRKVTKQTSneepklevflLAAETGSGKTLAYLAPLLDYLKRQEQEPfeeaeeeyesakdtgrp 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 133 QILILAPTREIAVQIHSVITAIGiKMEGLECHVFIGG-TPLSQDKTRL--KKCHIAVGSPGRIKQLIELDYLNPGSIRLF 209
Cdd:cd17965  111 RSVILVPTHELVEQVYSVLKKLS-HTVKLGIKTFSSGfGPSYQRLQLAfkGRIDILVTTPGKLASLAKSRPKILSRVTHL 189

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 210 ILDEADKLLEEgSFQEQINWIYSSLPASKQMLAVSATYPevlaNALTRYMRD--PTFVRL 267
Cdd:cd17965  190 VVDEADTLFDR-SFLQDTTSIIKRAPKLKHLILCSATIP----KEFDKTLRKlfPDVVRI 244
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 102-218 1.44e-08

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 54.33  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 102 DLIVQAKSGTGKTCVFSTIALDSLILenYSTQILILAPTREIAVQIHSVITAIGikMEGLECHVFIGGTPLSQDKT-RLK 180
Cdd:cd00046    3 NVLITAPTGSGKTLAALLAALLLLLK--KGKKVLVLVPTKALALQTAERLRELF--GPGIRVAVLVGGSSAEEREKnKLG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568923253 181 KCHIAVGSPGRI---KQLIELDYLNPgsIRLFILDEADKLL 218
Cdd:cd00046   79 DADIIIATPDMLlnlLLREDRLFLKD--LKLIIVDEAHALL 117
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
301-405 5.59e-06

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 50.11  E-value: 5.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 301 LQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGN--------MNQNQRLDAMAKLKQFHCRVLISTDLTSR 372
Cdd:COG1111  344 LKEQLGTNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFVGQaskegdkgLTQKEQIEILERFRAGEFNVLVATSVAEE 423

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568923253 373 GIDAEKVNLVVNLD-VPldweT---YMHRIGRAGRFG 405
Cdd:COG1111  424 GLDIPEVDLVIFYEpVP----SeirSIQRKGRTGRKR 456
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 363-413 1.51e-05

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 43.85  E-value: 1.51e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568923253 363 VLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTY 413
Cdd:cd18785   25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 313-405 4.25e-05

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 44.00  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 313 ALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQF--HCRVLISTDLTSRGIDAEKVNLVVNLDvpLD 390
Cdd:cd18793   30 VLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDpdIRVFLLSTKAGGVGLNLTAANRVILYD--PW 107

                         90
                 ....*....|....*....
gi 568923253 391 W----EtyMHRIGRAGRFG 405
Cdd:cd18793  108 WnpavE--EQAIDRAHRIG 124
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
 314-403 6.92e-05

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 43.79  E-value: 6.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 314 LVFSNLHSRA----QHLADILSSKGFPTE--CISGNMNQNQRLDAMAKLKQFHCRVLIST---DLtsrGIDAEKVNLVVN 384
Cdd:cd18796   42 LVFTNTRSQAerlaQRLRELCPDRVPPDFiaLHHGSLSRELREEVEAALKRGDLKVVVATsslEL---GIDIGDVDLVIQ 118

                         90
                 ....*....|....*....
gi 568923253 385 LDVPLDWETYMHRIGRAGR 403
Cdd:cd18796  119 IGSPKSVARLLQRLGRSGH 137
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 320-405 2.45e-04

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 41.81  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 320 HSR--AQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHR 397
Cdd:cd18794   38 LSRkeCEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQE 117


                 ....*...
gi 568923253 398 IGRAGRFG 405
Cdd:cd18794  118 SGRAGRDG 125
PRK13766 PRK13766
Hef nuclease; Provisional
 301-403 8.41e-04

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 42.94  E-value: 8.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 301 LQELFSKVPFNQALVFSNLHSRAQHLADILSSKGFPTECISGN--------MNQNQRLDAMAKLKQFHCRVLISTDLTSR 372
Cdd:PRK13766 356 VKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAVRFVGQaskdgdkgMSQKEQIEILDKFRAGEFNVLVSTSVAEE 435

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568923253 373 GIDAEKVNLVVNLD-VPLdwETYM-HRIGRAGR 403
Cdd:PRK13766 436 GLDIPSVDLVIFYEpVPS--EIRSiQRKGRTGR 466
SF2_C_dicer cd18802
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ...
 322-401 1.24e-03

C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350189 [Multi-domain]  Cd Length: 142  Bit Score: 39.88  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 322 RAQHLADILSSKGFPTEcisgNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRA 401
Cdd:cd18802   56 RCGFLIGRGNSSQRKRS----LMTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGRA 131
DEXHc_Hef cd18035
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ...
 103-214 2.31e-03

DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350793 [Multi-domain]  Cd Length: 181  Bit Score: 39.81  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 103 LIVqAKSGTGKTCVFSTIALDslILENYSTQILILAPTREIAVQ----IHSVITAigikmeGLECHVFIGGTPLSQDKTR 178
Cdd:cd18035   20 LIV-LPTGLGKTIIAILVAAD--RLTKKGGKVLILAPSRPLVEQhaenLKRVLNI------PDKITSLTGEVKPEERAER 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568923253 179 LKKCHIAVGSPgrikQLIELDYLNP----GSIRLFILDEA 214
Cdd:cd18035   91 WDASKIIVATP----QVIENDLLAGritlDDVSLLIFDEA 126
SF2_C_EcoAI-like cd18799
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ...
 313-383 2.77e-03

C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350186 [Multi-domain]  Cd Length: 116  Bit Score: 38.31  E-value: 2.77e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568923253 313 ALVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQF---HCRVLISTDLTSRGIDAEKVNLVV 383
Cdd:cd18799    9 TLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGDEALILLFFgelKPPILVTVDLLTTGVDIPEVDNVV 82
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
 313-403 6.15e-03

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 38.11  E-value: 6.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 313 ALVFSNLHSRAQHLADILSSKGF---PTECI-------SGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLV 382
Cdd:cd18801   33 VIIFSEFRDSAEEIVNFLSKIRPgirATRFIgqasgksSKGMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLI 112

                         90       100
                 ....*....|....*....|.
gi 568923253 383 VNLDVPLDWETYMHRIGRAGR 403
Cdd:cd18801  113 ICYDASPSPIRMIQRMGRTGR 133
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
 314-405 9.56e-03

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 39.31  E-value: 9.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568923253 314 LVFSNLHSRAQHLADILSSKGFPTECISGNMNQNQRLDAMAKLKQFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWET 393
Cdd:PRK11057 240 IIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIES 319

                         90
                 ....*....|..
gi 568923253 394 YMHRIGRAGRFG 405
Cdd:PRK11057 320 YYQETGRAGRDG 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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