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Conserved domains on  [gi|568918709|ref|XP_006500389|]
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transmembrane and coiled-coil domain-containing protein 5B isoform X1 [Mus musculus]

Protein Classification

TMCO5 domain-containing protein( domain architecture ID 12171749)

TMCO5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 33-311 8.56e-142

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


:

Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 401.02  E-value: 8.56e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   33 LKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIAL--SIGRVPERDDFNEILAQKETALKDLELESAKLEKKN 110
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLtrSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  111 KTLSKNVMELQKKISKGL-KNIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQSVFQLCEDQAHYIKKYQE 189
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSdKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  190 ILREMEKEKEVMLLEKEISKAQNDSSQVVKpgstLVETIQSNMEKNIIKKQKRKFWLRHFRYLFFMVMIVIRLLGYVFFH 269
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVK----LVETIQQNMEKTIIKKQKRIFWKRHFRYLFFMVLIFIRLLGYVLFH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568918709  270 LQYVNPDFLVDTLPMLMSRSSLKWLRDILFPFLTLEVEDVLP 311
Cdd:pfam14992 237 LQYINPDLLVDTLPKMLSRRTLWRLRCFLFPFLTLEVEDLLP 278
 
Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 33-311 8.56e-142

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 401.02  E-value: 8.56e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   33 LKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIAL--SIGRVPERDDFNEILAQKETALKDLELESAKLEKKN 110
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLtrSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  111 KTLSKNVMELQKKISKGL-KNIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQSVFQLCEDQAHYIKKYQE 189
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSdKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  190 ILREMEKEKEVMLLEKEISKAQNDSSQVVKpgstLVETIQSNMEKNIIKKQKRKFWLRHFRYLFFMVMIVIRLLGYVFFH 269
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVK----LVETIQQNMEKTIIKKQKRIFWKRHFRYLFFMVLIFIRLLGYVLFH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568918709  270 LQYVNPDFLVDTLPMLMSRSSLKWLRDILFPFLTLEVEDVLP 311
Cdd:pfam14992 237 LQYINPDLLVDTLPKMLSRRTLWRLRCFLFPFLTLEVEDLLP 278
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 21-253 1.89e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.38  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709    21 TEIPTLEAIKQNLKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIALSIGRVPErddFNEILAQKETALKDLE 100
Cdd:TIGR02169  805 EEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEE---LEEELEELEAALRDLE 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   101 LESAKLEKKNKTLSKNVMELQKKISKglknIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQSVFQLCEDQ 180
Cdd:TIGR02169  882 SRLGDLKKERDELEAQLRELERKIEE----LEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQ 957

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   181 ahyiKKYQEILREMEKEKEV-MLLEKEISKAQNDSSQVVKPGSTLVETIQSNMEK-NIIKKQKRKFWL-------RHFRY 251
Cdd:TIGR02169  958 ----AELQRVEEEIRALEPVnMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERiEEYEKKKREVFMeafeainENFNE 1033


                   ..
gi 568918709   252 LF 253
Cdd:TIGR02169 1034 IF 1035
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
26-243 6.15e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 6.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  26 LEAIKQNLKYLNSDLEKDLQRLDEANQIL----------LRKIQKKEESIQSLERDIALSIGRVPERDDFNEILAQKETA 95
Cdd:PRK03918 167 LGEVIKEIKRRIERLEKFIKRTENIEELIkekekeleevLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKE 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  96 LKDLELESAKLEKKNKTLSKNVMELQKKISKgLKNIASDPETLKKKVTEFkVKLQKSTESCAQQEKEIAKMESDYQSVFQ 175
Cdd:PRK03918 247 LESLEGSKRKLEEKIRELEERIEELKKEIEE-LEEKVKELKELKEKAEEY-IKLSEFYEEYLDELREIEKRLSRLEEEIN 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568918709 176 LCEDQAHYIKKYQEILREMEKEKEVMLLEKEISKAQNDSSQVVKPGSTLVETIQSNMEKNIIKKQKRK 243
Cdd:PRK03918 325 GIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKE 392
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
4-132 3.33e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.15  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   4 EAMEDAGQNPLDDEAEITEIPTLEAIKQNLKYLnSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIALSigRVPERD 83
Cdd:COG2433  383 EELIEKELPEEEPEAEREKEHEERELTEEEEEI-RRLEEQVERLEAEVEELEAELEEKDERIERLERELSEA--RSEERR 459

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568918709  84 DfneilAQKETALKDLELESAKLEKKNKTLSKNVMELQKKISKgLKNIA 132
Cdd:COG2433  460 E-----IRKDREISRLDREIERLERELEEERERIEELKRKLER-LKELW 502
 
Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 33-311 8.56e-142

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 401.02  E-value: 8.56e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   33 LKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIAL--SIGRVPERDDFNEILAQKETALKDLELESAKLEKKN 110
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLtrSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  111 KTLSKNVMELQKKISKGL-KNIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQSVFQLCEDQAHYIKKYQE 189
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSdKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  190 ILREMEKEKEVMLLEKEISKAQNDSSQVVKpgstLVETIQSNMEKNIIKKQKRKFWLRHFRYLFFMVMIVIRLLGYVFFH 269
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVK----LVETIQQNMEKTIIKKQKRIFWKRHFRYLFFMVLIFIRLLGYVLFH 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 568918709  270 LQYVNPDFLVDTLPMLMSRSSLKWLRDILFPFLTLEVEDVLP 311
Cdd:pfam14992 237 LQYINPDLLVDTLPKMLSRRTLWRLRCFLFPFLTLEVEDLLP 278
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 21-253 1.89e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.38  E-value: 1.89e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709    21 TEIPTLEAIKQNLKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIALSIGRVPErddFNEILAQKETALKDLE 100
Cdd:TIGR02169  805 EEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEE---LEEELEELEAALRDLE 881

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   101 LESAKLEKKNKTLSKNVMELQKKISKglknIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQSVFQLCEDQ 180
Cdd:TIGR02169  882 SRLGDLKKERDELEAQLRELERKIEE----LEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQ 957

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   181 ahyiKKYQEILREMEKEKEV-MLLEKEISKAQNDSSQVVKPGSTLVETIQSNMEK-NIIKKQKRKFWL-------RHFRY 251
Cdd:TIGR02169  958 ----AELQRVEEEIRALEPVnMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERiEEYEKKKREVFMeafeainENFNE 1033


                   ..
gi 568918709   252 LF 253
Cdd:TIGR02169 1034 IF 1035
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
26-243 6.15e-06

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 47.75  E-value: 6.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  26 LEAIKQNLKYLNSDLEKDLQRLDEANQIL----------LRKIQKKEESIQSLERDIALSIGRVPERDDFNEILAQKETA 95
Cdd:PRK03918 167 LGEVIKEIKRRIERLEKFIKRTENIEELIkekekeleevLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKE 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  96 LKDLELESAKLEKKNKTLSKNVMELQKKISKgLKNIASDPETLKKKVTEFkVKLQKSTESCAQQEKEIAKMESDYQSVFQ 175
Cdd:PRK03918 247 LESLEGSKRKLEEKIRELEERIEELKKEIEE-LEEKVKELKELKEKAEEY-IKLSEFYEEYLDELREIEKRLSRLEEEIN 324

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568918709 176 LCEDQAHYIKKYQEILREMEKEKEVMLLEKEISKAQNDSSQVVKPGSTLVETIQSNMEKNIIKKQKRK 243
Cdd:PRK03918 325 GIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKE 392
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 38-219 1.49e-05

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 45.96  E-value: 1.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   38 SDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIAlsigrvpERDDFNEILAQKETALKDlelesaklEKKNKTLSKNV 117
Cdd:pfam15905  97 QALEEELEKVEAKLNAAVREKTSLSASVASLEKQLL-------ELTRVNELLKAKFSEDGT--------QKKMSSLSMEL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  118 MELQKKISKGLKNIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQSVFQLCEDQAHYIKKYQEILREMEKE 197
Cdd:pfam15905 162 MKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEKLVSTEKEKIEEKSETEKLLEYITELSCVSEQVEKY 241

                         170       180
                  ....*....|....*....|..
gi 568918709  198 KEVMLLEKEISKAQNDSSQVVK 219
Cdd:pfam15905 242 KLDIAQLEELLKEKNDEIESLK 263
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 21-228 2.00e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 46.21  E-value: 2.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709    21 TEIPTLEAIKQNLKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIALSIGRvpeRDDFNEILAQKETALKDLE 100
Cdd:TIGR02169  294 EKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKR---RDKLTEEYAELKEELEDLR 370

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   101 LESAKLEKKNKTLSKNVMELQKKISKG-------LKNIASDPETLKKKVTE-------FKVKLQKSTESCAQQEKEIAKM 166
Cdd:TIGR02169  371 AELEEVDKEFAETRDELKDYREKLEKLkreinelKRELDRLQEELQRLSEEladlnaaIAGIEAKINELEEEKEDKALEI 450

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568918709   167 ESDYQSVFQLCEDQAHYIKKY---QEILREMEKEKEVMLLEKEISKAQNDSSQVVKPGSTLVETI 228
Cdd:TIGR02169  451 KKQEWKLEQLAADLSKYEQELydlKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEV 515
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
4-132 3.33e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 42.15  E-value: 3.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   4 EAMEDAGQNPLDDEAEITEIPTLEAIKQNLKYLnSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIALSigRVPERD 83
Cdd:COG2433  383 EELIEKELPEEEPEAEREKEHEERELTEEEEEI-RRLEEQVERLEAEVEELEAELEEKDERIERLERELSEA--RSEERR 459

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568918709  84 DfneilAQKETALKDLELESAKLEKKNKTLSKNVMELQKKISKgLKNIA 132
Cdd:COG2433  460 E-----IRKDREISRLDREIERLERELEEERERIEELKRKLER-LKELW 502
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 24-230 4.00e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.74  E-value: 4.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  24 PTLEAIKQNLKYLNSD---LEKDLQRLDEANQILLRKIQKKEESIQSLERDIalsigrvperDDFNEILAQKETALKDLE 100
Cdd:COG3883   16 PQIQAKQKELSELQAEleaAQAELDALQAELEELNEEYNELQAELEALQAEI----------DKLQAEIAEAEAEIEERR 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709 101 lesAKLEKKNKTL---------------SKNV------MELQKKISKGLKNIASDPETLKKKVTEFKVKLQKSTESCAQQ 159
Cdd:COG3883   86 ---EELGERARALyrsggsvsyldvllgSESFsdfldrLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEAL 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568918709 160 EKEIAKMESDYQSVFqlcEDQAHYIKKYQEILREMEKEKEVMLLEKEISKAQNDSSQVVKPGSTLVETIQS 230
Cdd:COG3883  163 KAELEAAKAELEAQQ---AEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAA 230
CAGE1 pfam15066
Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in ...
 63-204 4.20e-04

Cancer-associated gene protein 1 family; CAGE-1 is a family of proteins overexpressed in tumour tissues compared with surrounding tissues. CAGE-1 gene showed testis-specific expression among normal tissues and displayed wide expression in a variety of cancer cell lines and cancer tissues. CAGE-1 is predominantly expressed during post-meiotic stages. It localizes to the acrosomal matrix and acrosomal granule showing it to be a component of the acrosome of mammalian spermatids and spermatozoa.


Pssm-ID: 464481  Cd Length: 528  Bit Score: 41.74  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   63 ESIQSLERDIALsigrvperddfNEILAQKETALKDLELESAKLEKKNKTLSKNVMELQKKISK--GLKNIASDpetLKK 140
Cdd:pfam15066 305 ESLQPLEEDMAL-----------NEVLQKLKHTNRKQQMQIQDLQCSNLYLEKKVKELQMKITKqqVFVDIINK---LKE 370

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568918709  141 KVTE-----FKVKLQKStescaqqekEIAKMESDYQSVfqLCEDQAHyikkyqeiLREMEKEKEVMLLE 204
Cdd:pfam15066 371 NVEEliedkYNVILEKN---------DINKTLQNLQEI--LANTQKH--------LQESRKEKETLQLE 420
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 15-216 6.50e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 6.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  15 DDEAEITEIPTLEAIKQNLKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIALSIgrvPERDDFNEILAQKET 94
Cdd:COG1196  289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAE---EELEEAEAELAEAEE 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  95 ALKDLELESAKLEKKNKTLSKNVMELQKKISKGLKNIASDPETLKKKVTEfKVKLQKSTESCAQQEKEIAKMESDYQSVF 174
Cdd:COG1196  366 ALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER-LERLEEELEELEEALAELEEEEEEEEEAL 444

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 568918709 175 Q--LCEDQAHYIKKYQEILREMEKEKEVMLLEKEISKAQNDSSQ 216
Cdd:COG1196  445 EeaAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 43-206 1.07e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 39.91  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  43 DLQRLDEANQILLRKIQKKEESIQSLERDIAlsigrvperdDFNEILAQKETALKDLELESAKLEKKNKTLSKNVMELQK 122
Cdd:COG1579   11 DLQELDSELDRLEHRLKELPAELAELEDELA----------ALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709 123 KI-----SKGLKNIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQsvfQLCEDQAHYIKKYQEILREMEKE 197
Cdd:COG1579   81 QLgnvrnNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELA---ELEAELEEKKAELDEELAELEAE 157


                 ....*....
gi 568918709 198 KEVMLLEKE 206
Cdd:COG1579  158 LEELEAERE 166
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 31-243 2.54e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 39.62  E-value: 2.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   31 QNLKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDI----ALSIGRVPERDDFNEILAQKETALKDLELESAKL 106
Cdd:TIGR04523 387 KNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIerlkETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESL 466

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  107 EKKNKTLS---KNVMELQKKISKGLKNIASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKMESDYQSVFQLCEDQAHY 183
Cdd:TIGR04523 467 ETQLKVLSrsiNKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDE 546

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568918709  184 IKKYQEILREMEKEKEVMLLEKEISKAQNDSSQVVKPGSTLVETIQ--SNMEKNIIKKQKRK 243
Cdd:TIGR04523 547 LNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDqkEKEKKDLIKEIEEK 608
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 26-136 4.61e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.21  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  26 LEAIKQNLKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERdialsigrvpERDDFNEILAQKETALKDLELESAK 105
Cdd:COG4942  141 LKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEE----------ERAALEALKAERQKLLARLEKELAE 210

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568918709 106 LEKKNKTLSKNVMELQKKISKGLKNIASDPE 136
Cdd:COG4942  211 LAAELAELQQEAEELEALIARLEAEAAAAAE 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 22-219 5.96e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 37.82  E-value: 5.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  22 EIPTLEAIKQNLKYLNSDLEKDLQRLDEANQILLRKIQKKEESIQSLERDIALSIGrvpERDDFNEILAQKETALKDLEL 101
Cdd:COG4942   35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK---EIAELRAELEAQKEELAELLR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709 102 ESAKLEKKNKTL----------SKNVMELQKKISKGLKN----IASDPETLKKKVTEFKVKLQKSTESCAQQEKEIAKME 167
Cdd:COG4942  112 ALYRLGRQPPLAlllspedfldAVRRLQYLKYLAPARREqaeeLRADLAELAALRAELEAERAELEALLAELEEERAALE 191

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568918709 168 SDYQSVFQLCEDQAHYIKKYQEILREMEKEKEvmLLEKEISKAQNDSSQVVK 219
Cdd:COG4942  192 ALKAERQKLLARLEKELAELAAELAELQQEAE--ELEALIARLEAEAAAAAE 241
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 40-240 9.45e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 37.80  E-value: 9.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709   40 LEKDLQRLDEANQILLRKIQKKEES-----IQSLERDIALSIGRVP----ERDDFNEILAQKETALKDLELESAKLEKKN 110
Cdd:pfam17380 407 LEEERQRKIQQQKVEMEQIRAEQEEarqreVRRLEEERAREMERVRleeqERQQQVERLRQQEEERKRKKLELEKEKRDR 486

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568918709  111 KTLSK-NVMELQKKISKGLKNIASdpETLKKKVTEFKVKlQKSTESCAQQEKEIAKMESDYQSVFQ---LCEDQAHYIKK 186
Cdd:pfam17380 487 KRAEEqRRKILEKELEERKQAMIE--EERKRKLLEKEME-ERQKAIYEEERRREAEEERRKQQEMEerrRIQEQMRKATE 563

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568918709  187 YQEILREMEKEKEVMLLEKEISKAQNDSsqvvkPGSTLVETIQSNMEKNIIKKQ 240
Cdd:pfam17380 564 ERSRLEAMEREREMMRQIVESEKARAEY-----EATTPITTIKPIYRPRISEYQ 612
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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