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Conserved domains on  [gi|565480214|ref|XP_006297747|]
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galacturonokinase [Capsella rubella]

Protein Classification

galacturonokinase( domain architecture ID 11477218)

galacturonokinase is involved in the biosynthesis of UDP-galacturonic acid (UDP-GalA) from the salvaged GalA that is released during growth-dependent cell wall restructuring

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02865 PLN02865
galactokinase
 1-423 0e+00

galactokinase


:

Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 736.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214   1 MSWPTDSELISIKEAVSQMTGRDKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFEG 80
Cdd:PLN02865   4 GSWPSANELDEIRERVAAMSGRNSGEVRVVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  81 EVCFRVDEIQHPIGhtskndaSTPSPSKEKSVWGTYARGAVYALQTSKKNLKQGIVGYLSGSNGLDSSGLSSSAAVGVAY 160
Cdd:PLN02865  84 EVRFRVDEIQHPIA-------NVSSDSKEESNWGDYARGAVYALQSRGHALSQGITGYISGSEGLDSSGLSSSAAVGVAY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 161 LLALENANELTVSPTENIEYDRLIENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLV----QAPELEKPFRILLA 236
Cdd:PLN02865 157 LLALENANNLTVSPEDNIELDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVslqfQQPGGEKPFKILLA 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 237 FSGLRQALTTNPGYNLRVSECQEAAKVLLTACGNSELEPTLCNVEHAVYEAHKHELKPVLARRAEHYFSENMRVIKGREA 316
Cdd:PLN02865 237 FSGLRHALTNKPGYNLRVSECQEAARFLLEASGNDELEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEA 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 317 WASGNLEEFGKLISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEK 396
Cdd:PLN02865 317 WASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEK 396

                        410       420
                 ....*....|....*....|....*..
gi 565480214 397 AQPEFAKNLNGGKPVLICEAGDAARVL 423
Cdd:PLN02865 397 AQPELASNINGDKPVLICEAGDCARVL 423
 
Name Accession Description Interval E-value
PLN02865 PLN02865
galactokinase
 1-423 0e+00

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 736.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214   1 MSWPTDSELISIKEAVSQMTGRDKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFEG 80
Cdd:PLN02865   4 GSWPSANELDEIRERVAAMSGRNSGEVRVVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  81 EVCFRVDEIQHPIGhtskndaSTPSPSKEKSVWGTYARGAVYALQTSKKNLKQGIVGYLSGSNGLDSSGLSSSAAVGVAY 160
Cdd:PLN02865  84 EVRFRVDEIQHPIA-------NVSSDSKEESNWGDYARGAVYALQSRGHALSQGITGYISGSEGLDSSGLSSSAAVGVAY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 161 LLALENANELTVSPTENIEYDRLIENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLV----QAPELEKPFRILLA 236
Cdd:PLN02865 157 LLALENANNLTVSPEDNIELDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVslqfQQPGGEKPFKILLA 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 237 FSGLRQALTTNPGYNLRVSECQEAAKVLLTACGNSELEPTLCNVEHAVYEAHKHELKPVLARRAEHYFSENMRVIKGREA 316
Cdd:PLN02865 237 FSGLRHALTNKPGYNLRVSECQEAARFLLEASGNDELEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEA 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 317 WASGNLEEFGKLISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEK 396
Cdd:PLN02865 317 WASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEK 396

                        410       420
                 ....*....|....*....|....*..
gi 565480214 397 AQPEFAKNLNGGKPVLICEAGDAARVL 423
Cdd:PLN02865 397 AQPELASNINGDKPVLICEAGDCARVL 423
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
23-424 1.37e-77

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 245.45  E-value: 1.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  23 DKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFEGEVCFRVDEIqhpightskndas 102
Cdd:COG0153   14 GEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDL------------- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 103 tpSPSKEKSvWGTYARGAVYALQtsKKNLKqgIVGY-------------LSGSNGldssglsssaaVGVAYLLALENANE 169
Cdd:COG0153   81 --EPGEEDG-WANYVRGVAWALQ--ERGYK--LGGFdlvidgdvplgagLSSSAA-----------LEVAVALALNDLFG 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 170 LTVSPTENIEYDRLIENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLVQAPEleKPFRILLAFSGLRQALTTNpG 249
Cdd:COG0153  143 LGLDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADS-E 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 250 YNLRVSECQEAAKVLltacgnsELePTLCNVEHAVYEAHKHELK-PVLARRAEHYFSENMRVIKGREAWASGNLEEFGKL 328
Cdd:COG0153  220 YNERRAECEAAAAIL-------GV-KSLRDVTLEDLEAARARLGdEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 329 ISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEKAQpefaknlnGG 408
Cdd:COG0153  292 MNASHASLRDDYEVSCPELDTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKT--------GL 363

                        410
                 ....*....|....*..
gi 565480214 409 KP-VLICEAGDAARVLF 424
Cdd:COG0153  364 EPdFYVVKPSDGARRLA 380
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 23-61 3.95e-07

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 46.29  E-value: 3.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 565480214   23 DKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILL 61
Cdd:pfam10509   8 GKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYV 46
 
Name Accession Description Interval E-value
PLN02865 PLN02865
galactokinase
 1-423 0e+00

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 736.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214   1 MSWPTDSELISIKEAVSQMTGRDKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFEG 80
Cdd:PLN02865   4 GSWPSANELDEIRERVAAMSGRNSGEVRVVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  81 EVCFRVDEIQHPIGhtskndaSTPSPSKEKSVWGTYARGAVYALQTSKKNLKQGIVGYLSGSNGLDSSGLSSSAAVGVAY 160
Cdd:PLN02865  84 EVRFRVDEIQHPIA-------NVSSDSKEESNWGDYARGAVYALQSRGHALSQGITGYISGSEGLDSSGLSSSAAVGVAY 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 161 LLALENANELTVSPTENIEYDRLIENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLV----QAPELEKPFRILLA 236
Cdd:PLN02865 157 LLALENANNLTVSPEDNIELDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVslqfQQPGGEKPFKILLA 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 237 FSGLRQALTTNPGYNLRVSECQEAAKVLLTACGNSELEPTLCNVEHAVYEAHKHELKPVLARRAEHYFSENMRVIKGREA 316
Cdd:PLN02865 237 FSGLRHALTNKPGYNLRVSECQEAARFLLEASGNDELEPLLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEA 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 317 WASGNLEEFGKLISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEK 396
Cdd:PLN02865 317 WASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEK 396

                        410       420
                 ....*....|....*....|....*..
gi 565480214 397 AQPEFAKNLNGGKPVLICEAGDAARVL 423
Cdd:PLN02865 397 AQPELASNINGDKPVLICEAGDCARVL 423
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
23-424 1.37e-77

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 245.45  E-value: 1.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  23 DKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFEGEVCFRVDEIqhpightskndas 102
Cdd:COG0153   14 GEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEVEFDLDDL------------- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 103 tpSPSKEKSvWGTYARGAVYALQtsKKNLKqgIVGY-------------LSGSNGldssglsssaaVGVAYLLALENANE 169
Cdd:COG0153   81 --EPGEEDG-WANYVRGVAWALQ--ERGYK--LGGFdlvidgdvplgagLSSSAA-----------LEVAVALALNDLFG 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 170 LTVSPTENIEYDRLIENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLVQAPEleKPFRILLAFSGLRQALTTNpG 249
Cdd:COG0153  143 LGLDPVELAKIGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPL--EGYALVIVDTNVKHSLADS-E 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 250 YNLRVSECQEAAKVLltacgnsELePTLCNVEHAVYEAHKHELK-PVLARRAEHYFSENMRVIKGREAWASGNLEEFGKL 328
Cdd:COG0153  220 YNERRAECEAAAAIL-------GV-KSLRDVTLEDLEAARARLGdEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKL 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 329 ISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEKAQpefaknlnGG 408
Cdd:COG0153  292 MNASHASLRDDYEVSCPELDTLVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKT--------GL 363

                        410
                 ....*....|....*..
gi 565480214 409 KP-VLICEAGDAARVLF 424
Cdd:COG0153  364 EPdFYVVKPSDGARRLA 380
PRK05322 PRK05322
galactokinase; Provisional
 23-423 5.62e-41

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 149.62  E-value: 5.62e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  23 DKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFE--GEVCFRVDEIqhpightsknd 100
Cdd:PRK05322  15 GEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFEdlGIIEFDLDDL----------- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 101 astpSPSKEKSvWGTYARGAVYALQTSKKNLKQG--IVGY--------LSGSngldssgLSSSAAVGVAyllaLENANEL 170
Cdd:PRK05322  84 ----SFDKEDD-WANYPKGVLKFLQEAGYKIDHGfdILIYgnipngagLSSS-------ASIELLTGVI----LKDLFNL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 171 TVSPTENIEYDRLIENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLVqaPELEKPFRILLAFSGLRQALTtNPGY 250
Cdd:PRK05322 148 DLDRLELVKLGQKTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYV--PLDLGDYVIVIMNTNKRRELA-DSKY 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 251 NLRVSECQEAAKVLltacgNSELE-PTLCNVEHAVYEAHKHELK-PVLARRAEHYFSENMRVIKGREAWASGNLEEFGKL 328
Cdd:PRK05322 225 NERRAECEKALEEL-----QKKLDiKSLGELTEEEFDEYSYLIKdETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRL 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 329 ISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEKA---QPEFaknl 405
Cdd:PRK05322 300 MNASHVSLRDDYEVTGLELDTLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKigyAASF---- 375

                        410
                 ....*....|....*...
gi 565480214 406 nggkpvLICEAGDAARVL 423
Cdd:PRK05322 376 ------YVAEIGDGAREL 387
PRK03817 PRK03817
galactokinase; Provisional
 29-396 1.20e-35

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 134.35  E-value: 1.20e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  29 VVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGdtKVQLRSAQFEGEVCFRVDEIQhpightskndastpspsK 108
Cdd:PRK03817   2 KVKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSE--KFIFYSENFNEEKTFELDKLE-----------------K 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 109 EKSvWGTYARGAVYALQTSKKNLKqGIVGYLSGsNGLDSSGLSSSAAVGVAYLLALENANELTVSPTENIEYDRLIENGY 188
Cdd:PRK03817  63 LNS-WADYIKGVIWVLEKRGYEVG-GVKGKVSS-NLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEF 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 189 LGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLVQAPeleKPFRILLAFSGLRQALtTNPGYNLRVSECQEAAKVLltac 268
Cdd:PRK03817 140 VGVPCGIMDQFAVAFGKKDHAIFLDTMTLEYEYVPFP---EDYEILVFDTGVKREL-ASSEYNERRQECEEALKIL---- 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 269 G-NSELEptlcnvehaVYEAHKHELKPVLARRAEHYFSENMRVIKGREAWASGNLEEFGKLISASGLSSIENYECGAEPL 347
Cdd:PRK03817 212 GkKSSKE---------VTEEDLSKLPPLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEEL 282

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 565480214 348 IQLYKILLKApGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEK 396
Cdd:PRK03817 283 DFFVEFALEL-GAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKK 330
PRK05101 PRK05101
galactokinase; Provisional
 29-397 8.01e-24

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 101.92  E-value: 8.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  29 VVVAPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFEGEVcfrvDE--IQHPIghtskndasTPSP 106
Cdd:PRK05101  22 TIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDNQQ----DEfsLDAPI---------VPHP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 107 SKEksvWGTYARGAVYALQTSKKNLK-----------QGiVGyLSGSngldssglsssAAVGVAYLLALENANELTVSPT 175
Cdd:PRK05101  89 EQQ---WANYVRGVVKHLQERNPDFGgadlvisgnvpQG-AG-LSSS-----------ASLEVAVGQTFQQLYHLPLSGA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 176 ENIEYDRLIENGYLGLRNGILDQsaiLLSSYG---CLTYMDCKTMNHKLVQAPElekPFRILLAFSGLRQALTTNPgYNL 252
Cdd:PRK05101 153 EIALNGQEAENQFVGCNCGIMDQ---LISALGkkdHALLIDCRSLETKAVPMPE---GVAVVIINSNVKRGLVDSE-YNT 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 253 RVSECQEAAKVLltacGNSELEptlcNVEHAVYEAHKHELKPVLARRAEHYFSENMRVIKGREAWASGNLEEFGKLISAS 332
Cdd:PRK05101 226 RRQQCETAARFF----GVKALR----DVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAES 297

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 565480214 333 GLSSIENYECGAEP---LIQLYKILLKAPGvyGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEKA 397
Cdd:PRK05101 298 HASMRDDFEITVPQidtLVEIVKAVIGDQG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAK 363
PRK00555 PRK00555
galactokinase; Provisional
 32-378 1.09e-20

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 92.62  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  32 APYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDTKVQLRSAQFEGEVCFRVDeiqhpighTSKNDASTpspskeks 111
Cdd:PRK00555   7 APGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSARIPLD--------TTPGQVTG-------- 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 112 vWGTYARGAVYALQTSKKNLKQGIVGYLS----GSngldssglsssaavGVAYLLALENANELTVSPTENIEYDRL---- 183
Cdd:PRK00555  71 -WAAYAAGVIWALRGAGHPVPGGAMSITSdveiGS--------------GLSSSAALECAVLGAVGAATGTRIDRLeqar 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 184 ----IENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLVQApELEKPFRILLAFSGLRQALTTNPGYNLRVSECQE 259
Cdd:PRK00555 136 laqrAENEYVGAPTGLLDQLAALFGAPKTALLIDFRDLTVRPVAF-DPDAAGVVLLLMDSRARHRHAGGEYAARRASCER 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 260 AAKVLLTacgnselePTLCNVEHAVYEAHKHELKPVLARRAEHYFSENMRVIKGREAWASGNLEEFGKLISASGLSSIEN 339
Cdd:PRK00555 215 AAADLGV--------SSLRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDD 286

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 565480214 340 YECGAEPLIQLYKILLKApGVYGARFSGAGFRGCCVAFV 378
Cdd:PRK00555 287 FEITTERIDLIADSAVRA-GALGARMTGGGFGGCVIALV 324
PLN02521 PLN02521
galactokinase
 32-397 9.15e-11

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 63.57  E-value: 9.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  32 APYRICPLGAHIDHQGGTVSAMTINKgillgfvpsgDTKVQLRSAQFEGEVcfrvdeiqhPIGHTskNDASTP-----SP 106
Cdd:PLN02521  53 SPGRVNLIGEHIDYEGYSVLPMAIRQ----------DTIVAIRRAEGSKKL---------RIANV--NDKYTTctfpaDP 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 107 SKE----KSVWGTY---ARGAVYALQTSKKNLKQGIVGY-------------LSGSngldssglsssAAVGVAYLLALEN 166
Cdd:PLN02521 112 DQEvdlaNHKWGNYficGYKGVFEFLKSKGVDVGPPVGLdvvvdgtvptgsgLSSS-----------AALVCSAAIAIMA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 167 ANELTVSPTENIEYDRLIENgYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLVQAPElEKPFRIL--LAFSglRQAL 244
Cdd:PLN02521 181 ALGLNFTKKEVAQFTCKCER-HIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPA-GGTFVIAnsLAES--NKAV 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 245 TTNPGYNLRVSECQEAAKVLLTACGNSELEP-----TLCNVE----------------HAVYEaHKHElKPVLAR----- 298
Cdd:PLN02521 257 TAATNYNNRVVECRLAAIVLAVKLGMSAEEAiskvkTLSDVEglcvsfagshgssdpaVAVKE-LLHE-GPYTAEeieei 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 299 -----------------------------RAEHYFSENMRVIKGREAWASG-----NLEEFGKLISASGLSSIENYECGA 344
Cdd:PLN02521 335 lgesltsifknsptslavlkaakhfklhqRAVHVYSEAKRVHAFRDTVSSSlseeeKLKKLGDLMNESHYSCSVLYECSC 414

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 565480214 345 EPLIQLYKILlKAPGVYGARFSGAGFRGCCVAFVDAEKAEAAAAYVKDEYEKA 397
Cdd:PLN02521 415 PELEELVKVC-RDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKS 466
PTZ00290 PTZ00290
galactokinase; Provisional
 32-373 5.66e-08

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 54.83  E-value: 5.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214  32 APYRICPLGAHIDHQGGTVSAMTINKG--ILLGFVPSGdTKVQLRSAQFEGEvCFRVDEIqhpiGHTSKNDAstpspske 109
Cdd:PTZ00290  42 APGRVNFIGEHVDYMGGYVCPAAVLEGchILVGRVKHF-CDHKLRFATETDE-HFVLDHL----GGAKHNKA-------- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 110 ksvWGTYARGAVyALQTSKKNLK------QGIVGYLSGSnGLDSSGLSSSAAVGVAYLLALE-------------NANEL 170
Cdd:PTZ00290 108 ---WTTFVRGAA-TLRLNRLGVAidapslQGVCMVVHGT-LPMGAGMSASASFGVALLNAINtvvtrrykgcptsPGRRY 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 171 TVSPT----ENIEY---DRLIENGYLGLRNGILDQSAILLSSYGCLTYMDCKTMNHKLVQ-APELEKPFRILLAFSGLRQ 242
Cdd:PTZ00290 183 SILPPmskeELIELakqARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDmTPLLGDGACFLLIDSMIKH 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565480214 243 ALT--TNPGYN-LRVSECQEAAKVLLTACGNSELEPTLC-----------NVEHAVYEAHKHeLKPVLARRAEHYFSENM 308
Cdd:PTZ00290 263 DLLggTAGMYNtVRSDQEGAQKKIGKHRYRGKPFTFSDLvrnpkkytfdgDVVAFMESCKPL-MTPGEFERGTYNIMEQI 341

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 565480214 309 RVIKGRE---AWASGNLEE----FGKLISASGLSSIENYECGAEPLIQLYKILLKAPGVYGARFSGAGFRGC 373
Cdd:PTZ00290 342 RTLEFIKlndPELPLSREErfrkAGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGRMMGGGFGGC 413
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 23-61 3.95e-07

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 46.29  E-value: 3.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 565480214   23 DKGEVRVVVAPYRICPLGAHIDHQGGTVSAMTINKGILL 61
Cdd:pfam10509   8 GKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYV 46
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 310-378 2.24e-04

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 42.91  E-value: 2.24e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 565480214 310 VIKGREAWASGNLEEFGKLISAS-------GLSSienyecgaEPLIQLYKILLKApGVYGARFSGAGFRGCCVAFV 378
Cdd:COG1577  211 VEEAIEALEEGDLEALGELMNENhgllralGVST--------PELDRLVEAARKA-GALGAKLTGAGGGGCVIALA 277
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 314-379 3.11e-04

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 39.38  E-value: 3.11e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 565480214  314 REAWASGNLEEFGKLISASGLSSIENYECGAEP--LIQLYKILLKApgVYGARFSGAGFRGCCVAFVD 379
Cdd:pfam08544   2 LEALLRGDLEELGKLLTESAESLEPLLVVGILPpeLDELLEALLEL--GLGAKLSGSGGGPTVFALFK 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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