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Conserved domains on  [gi|565355939|ref|XP_006344832|]
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PREDICTED: probable transmembrane ascorbate ferrireductase 2 [Solanum tuberosum]

Protein Classification

cytochrome b family protein( domain architecture ID 10010861)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02680 PLN02680
carbon-monoxide oxygenase
 1-232 2.08e-135

carbon-monoxide oxygenase


:

Pssm-ID: 215365  Cd Length: 232  Bit Score: 379.91  E-value: 2.08e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939   1 MAVPVVRFPIFLLVRVIGIAVAALVLIWNVHYRGGLALISDNKALIFNVHPVVMVIGLVLLNGEAMLAYKTVSGTKSFRK 80
Cdd:PLN02680   1 MAVPVIRFPIFMLVRLLGVIVAALVLTWTVHYRGGLALSSDNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVPGTKNLKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  81 SVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFG 160
Cdd:PLN02680  81 LVHLTLQFLAFCLSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 565355939 161 IYIYALAIATCATGFLEKATFLQASHIISRYSTEALLVNCLGVLIVVLGGLVILAVVSPMNGRSDIIRGPAE 232
Cdd:PLN02680 161 IYIYALAVATATTGILEKATFLQSNKVISRYSTEAMLVNSLGILIVVLGGFVILAIVTPLNGKGDVLRGSTE 232
 
Name Accession Description Interval E-value
PLN02680 PLN02680
carbon-monoxide oxygenase
 1-232 2.08e-135

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 379.91  E-value: 2.08e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939   1 MAVPVVRFPIFLLVRVIGIAVAALVLIWNVHYRGGLALISDNKALIFNVHPVVMVIGLVLLNGEAMLAYKTVSGTKSFRK 80
Cdd:PLN02680   1 MAVPVIRFPIFMLVRLLGVIVAALVLTWTVHYRGGLALSSDNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVPGTKNLKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  81 SVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFG 160
Cdd:PLN02680  81 LVHLTLQFLAFCLSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 565355939 161 IYIYALAIATCATGFLEKATFLQASHIISRYSTEALLVNCLGVLIVVLGGLVILAVVSPMNGRSDIIRGPAE 232
Cdd:PLN02680 161 IYIYALAVATATTGILEKATFLQSNKVISRYSTEAMLVNSLGILIVVLGGFVILAIVTPLNGKGDVLRGSTE 232
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 40-183 1.87e-70

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 211.78  E-value: 1.87e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  40 SDNKALIFNVHPVVMVIGLVLLNGEAMLAYKTVSGTKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSW 119
Cdd:cd08766    1 SDNKGLIFNVHPVLMVIGFIFLAGEAILAYKTVPGSREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSW 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 565355939 120 LGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKATFLQ 183
Cdd:cd08766   81 LGIGTISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTFLQ 144
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 49-182 1.04e-48

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 156.23  E-value: 1.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939   49 VHPVVMVIGLVLLNGEAMLAYKTVSG---TKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCL 125
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTrrlSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 565355939  126 FLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKATFL 182
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 49-175 2.09e-34

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 119.64  E-value: 2.09e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939    49 VHPVVMVIGLVLLNGEAMLAYK--TVSGTKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCLF 126
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARplTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 565355939   127 LFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGF 175
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
 
Name Accession Description Interval E-value
PLN02680 PLN02680
carbon-monoxide oxygenase
 1-232 2.08e-135

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 379.91  E-value: 2.08e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939   1 MAVPVVRFPIFLLVRVIGIAVAALVLIWNVHYRGGLALISDNKALIFNVHPVVMVIGLVLLNGEAMLAYKTVSGTKSFRK 80
Cdd:PLN02680   1 MAVPVIRFPIFMLVRLLGVIVAALVLTWTVHYRGGLALSSDNKDLIFNVHPVLMVIGLVLLNGEAMLAYKTVPGTKNLKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  81 SVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFG 160
Cdd:PLN02680  81 LVHLTLQFLAFCLSLIGVWAALKFHNEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWYPGGSRNSRASLLPWHVFFG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 565355939 161 IYIYALAIATCATGFLEKATFLQASHIISRYSTEALLVNCLGVLIVVLGGLVILAVVSPMNGRSDIIRGPAE 232
Cdd:PLN02680 161 IYIYALAVATATTGILEKATFLQSNKVISRYSTEAMLVNSLGILIVVLGGFVILAIVTPLNGKGDVLRGSTE 232
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 40-183 1.87e-70

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 211.78  E-value: 1.87e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  40 SDNKALIFNVHPVVMVIGLVLLNGEAMLAYKTVSGTKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSW 119
Cdd:cd08766    1 SDNKGLIFNVHPVLMVIGFIFLAGEAILAYKTVPGSREVQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHSW 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 565355939 120 LGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKATFLQ 183
Cdd:cd08766   81 LGIGTISLFGLQWLFGFVTFWFPGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEKLTFLQ 144
PLN02810 PLN02810
carbon-monoxide oxygenase
 1-218 2.65e-62

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 194.27  E-value: 2.65e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939   1 MAVPVVRFPIFLLVRVIGIAVAALVLIWNVHYRGGLALISDNKALIFNVHPVVMVIGLVLLNGEAMLAYKTVSGTKSFRK 80
Cdd:PLN02810   1 MAVGINALPLTFVAHALAVIGAIMVLVWSIYYRGGLAWEATNKNLIFNLHPVLMLIGLIIIGGEAIMSYKSLPLKKEVKK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  81 SVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFG 160
Cdd:PLN02810  81 LIHLVLHAIALILGIFGICAAFKNHNESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFFPGGSTNLRSGSLPWHVLFG 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 565355939 161 IYIYALAIATCATGFLEKATFLQASHiISRYSTEALLVNCLGVLIVVLGGLVILAVVS 218
Cdd:PLN02810 161 LFVYILAVGNAALGFLEKLTFLESGG-LDKYGSEALLVNFTAIITILYGAFVVLTALA 217
PLN02351 PLN02351
cytochromes b561 family protein
 2-219 7.17e-61

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 191.27  E-value: 7.17e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939   2 AVPVVRFPIFLLVRVIGIAVAALVLIWNVHYRGG-LALISDNKALIFNV-HPVVMVIGLVLLNGEAMLAYKTVSGTKSFR 79
Cdd:PLN02351   4 VDSSSLLPLLLFARLSGLVVAVLVLYWALFFKSSfLPQSTSQEDLVYAVlHPLLMVIGFILISGEAILVHRWLPGSRKTK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  80 KSVHLVLQFLAFFLSLIGLWAawKFHNDKGI-DNFYSLHSWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAF 158
Cdd:PLN02351  84 KSVHLWLQGLALASGVFGIWT--KFHGQDGIvANFYSLHSWMGLICVSLFGAQWLTGFMSFWHRGEMRTTRTTVLPWHVF 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 565355939 159 FGIYIYALAIATCATGFLEKATFLQASHIISRYSTEALLVNCLGVLIVVLGGLVILAVVSP 219
Cdd:PLN02351 162 LGLYTYGLAVATAETGLLEKLTFLQTKRNVSKHGSESMVVNGLGLGLALLSGIVILAAVLP 222
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 24-219 1.46e-52

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 169.05  E-value: 1.46e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  24 LVLIWNVHYRGGLAliSDNKALIFNVHPVVMVIGLVLLNGEAMLAYKTVSGTKSFR-KSVHLVLQFLAFFLSLIGLWAAW 102
Cdd:cd08764    3 LVGIWLGKFRGGFS--WTGPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRlKLLHAVLHLLAFILAVIGLKAVF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939 103 KFHN--DKGIDNFYSLHSWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKAT 180
Cdd:cd08764   81 DSHNlaKPPIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPETLRAAYLPLHVFFGLFIFVLAVATALLGITEKAF 160

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 565355939 181 FLQASHiiSRYSTEALLVNCLGVLIVVLGGLVILAVVSP 219
Cdd:cd08764  161 FSLNKY--SNLPAEGVLGNFIGIVLVIFGGLVVYLVTEP 197
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 49-182 1.04e-48

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 156.23  E-value: 1.04e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939   49 VHPVVMVIGLVLLNGEAMLAYKTVSG---TKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCL 125
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNSTrrlSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 565355939  126 FLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKATFL 182
Cdd:pfam03188  81 ILYALQWVGGFVTFLFPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEKLIFQ 137
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 46-175 3.44e-35

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 121.62  E-value: 3.44e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  46 IFNVHPVVMVIGLVLLNGEAMLAYKT-VSGTKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFC 124
Cdd:cd08554    1 EFNWHPLLMVIGFVFLMGEALLVYRVfRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLAT 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 565355939 125 LFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGF 175
Cdd:cd08554   81 VLLFLLQFLSGFVLFLLPLLRLSYRSSLLPFHRFFGLAIFVLAIATILLGI 131
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 49-175 2.09e-34

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 119.64  E-value: 2.09e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939    49 VHPVVMVIGLVLLNGEAMLAYK--TVSGTKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCLF 126
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARplTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 565355939   127 LFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGF 175
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGLPSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 11-181 2.54e-34

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 121.13  E-value: 2.54e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  11 FLLVRVIGIAVAALVLIWNVHYRGGLALisDNKALIFNVHPVVMVIGLVLLNGEAMLAYK---TVSGTKSFRKSVHLVLQ 87
Cdd:cd08762    1 CLLLGILGIACVVLVVHWNQMWRGGFAW--DGSSKNFNWHPVLMVTGMVVLYGNAALVYRiplTWGGPKLPWKLLHAGLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  88 FLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALA 167
Cdd:cd08762   79 LLAFILTVIGLCAVFNFHNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWAPMWLRALVKPIHVFFGAMILVLS 158

                        170
                 ....*....|....
gi 565355939 168 IATCATGFLEKATF 181
Cdd:cd08762  159 IASCISGINEKLFF 172
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 45-181 3.28e-28

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 104.13  E-value: 3.28e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  45 LIFNVHPVVMVIGLVLLNGEAMLAYKTVSG-TKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLF 123
Cdd:cd08763    5 LQFNVHPLCMVLGLVFLCGEALLVYRVFRNeTKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSWCGIL 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 565355939 124 CLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKATF 181
Cdd:cd08763   85 TFVLYFLQWLIGFSFFLFPGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEKLLF 142
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 41-181 1.72e-24

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 94.96  E-value: 1.72e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  41 DNKALIFNVHPVVMVIGLVLLNGEAMLAYK---TVSGTKSFRKSVHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLH 117
Cdd:cd08765    6 DGGAAEFNWHPVLMVIGFIFIQGIAIIVYRlpwTWKCSKLLMKLIHAGLHILAFILAIISVVAVFVFHNAKNIPNMYSLH 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 565355939 118 SWLGLFCLFLFGVQWAVGFATFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKATF 181
Cdd:cd08765   86 SWVGLAAVILYPLQLVLGISVYLLPVAPVRLRAALMPLHVYSGLFIFGTVIATALMGITEKLIF 149
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 50-179 3.60e-14

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 68.08  E-value: 3.60e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  50 HPVVMVIGLVLLNGEAMLAY-KTVSGTKSFRKS---VHLVLQFLAFFLSLIGLWAAWKFHNDKGIDNFYSLHSWLGLFCL 125
Cdd:cd08761   24 HPLLMSLGFLLLMTEALLLLqPTSSLTKLARKTkvrLHWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGILGLVTV 103

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 565355939 126 FLFGVQWAVGFATFWYPGGSRNSR--ATLLPWHAFFGIYIYALAIATCATGFLEKA 179
Cdd:cd08761  104 ILIVLQALGGLALLYPPGLRRGESkaKKLKKYHRLSGYVAYLLGLATLVLGLETRW 159
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 31-213 6.97e-07

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 48.11  E-value: 6.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939  31 HYRGGLALISDNKALIFNVHPVVMVIGLVLLN--GEAMLAYKTVSGTKSFRksVHLVLQFLAFFLSLIGLWAAWKfHNDK 108
Cdd:cd08760   20 PFLLPNGSSVGSSDTLIKAHGVLMAIAWGILMpiGALLARYFLLGDPVWFY--LHAGLQLLAVLLAIAGFVLGIV-LVQG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 565355939 109 GIDNFYSLHSWLGLFCLFLFGVQWAVGfatFWYPGGSRNSRATLLPWHAFFGIYIYALAIATCATGFLEKATFLQASHII 188
Cdd:cd08760   97 GGGSLNNAHAILGIIVLALAILQPLLG---LLRPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGLDLAGAGTPKAWKI 173

                        170       180
                 ....*....|....*....|....*
gi 565355939 189 srysteaLLVNCLGVLIVVLGGLVI 213
Cdd:cd08760  174 -------AYGVVVAVLALVYLILEI 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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