|
Name |
Accession |
Description |
Interval |
E-value |
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
657-1143 |
0e+00 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 774.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 657 KIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATY 736
Cdd:TIGR00614 1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 737 LTGDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASNRLISTLEnlyERKLLARFVIDEAHCVSQWGHDFRQDYKRMNM 816
Cdd:TIGR00614 81 LNSAQTKEQQLNVLTDL--KDGKIKLLYVTPEKISASNRLLQTLE---ERKGITLIAVDEAHCISQWGHDFRPDYKALGS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 817 LRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPkKVAFDCLEWIRKHHPYDSGIIYCL 896
Cdd:TIGR00614 156 LKQKFPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTP-KILEDLLRFIRKEFEGKSGIIYCP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 897 SRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWInQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQE 976
Cdd:TIGR00614 235 SRKKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQ-RDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 977 SGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNhhtRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCK 1056
Cdd:TIGR00614 314 SGRAGRDGLPSECHLFYAPADMNRLRRLLMEEPDGN---FRTYKLKLYEMMEYCLNSSTCRRLILLSYFGEKGFNKSFCI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1057 KHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNikhvgpsGRFTMNMLVDIFLGSKSAKIQSGIFGKGSA 1136
Cdd:TIGR00614 391 MGTEKCCDNCCKRLDYKTKDVTDKVYDFGPQAQKALSAVGRLN-------QKFGMGYPVDFLRGSNSQKIRDGGFRKHSL 463
|
....*..
gi 564730687 1137 YSRHNAE 1143
Cdd:TIGR00614 464 YGRGKDE 470
|
|
| BLM_N |
pfam16202 |
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate ... |
1-368 |
0e+00 |
|
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate Bloom syndrome proteins. The exact function is not known.
Pssm-ID: 465064 Cd Length: 370 Bit Score: 570.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1 MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNT 80
Cdd:pfam16202 1 MAAVPQNNLQEQLERHSARKLNNKLSLSKPKSSGFTFKKKTSSGNDVSVTSVSVAKTPVLSDKDVNVTEAFSFSEPLPHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 81 TNQQ-RVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDD 159
Cdd:pfam16202 81 TNQQtRINDFFKNAPAGQQTKRAGSKPLLPDSSQTPQEVSCTTQVTPAVKKPPDAVFKKLEFSSSFDSFISLNDWDDMDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 160 FDTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICID 239
Cdd:pfam16202 161 FDTSGNSKAFVTPPRNHFVRVSTAQKSKKSKRNFSKAQLSKANTVKADLTPSSGESKQVDLTKEQLDDSEWLSSDVICID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 240 DGPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDTDFVPPSPEE-IISASSSSSKC 318
Cdd:pfam16202 241 DDPISEELINEDTQESHSLKTHLGDERDNSEKKKHLEETELHSVEKSPCVELNEDDYDIDFVPPSPEEeVISSSSSSLKC 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 564730687 319 LSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCDARQISL 368
Cdd:pfam16202 321 FSMLKDLDTSDKEKDGLSTSEDLLSKPEKMTTQQPDQETSTDCDARQISL 370
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
654-1150 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 557.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 654 EMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIP 733
Cdd:COG0514 4 DALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAAGIR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 734 ATYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEkicasnRLIS--TLENLYERKLlARFVIDEAHCVSQWGHDFRQDY 811
Cdd:COG0514 84 AAFLNSSLSAEERREVLRALRAGE--LKLLYVAPE------RLLNprFLELLRRLKI-SLFAIDEAHCISQWGHDFRPDY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 812 KRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPyDSG 891
Cdd:COG0514 155 RRLGELRERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKPPDDKLAQLLDFLKEHPG-GSG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 892 IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGcQVICATIAFGMGIDKPDVRFVIHASLPKSVE 971
Cdd:COG0514 234 IVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEV-DVIVATIAFGMGIDKPDVRFVIHYDLPKSIE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 972 GYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHfNNLYSMVHYCEnITECRRIQLLAYFGENGFN 1051
Cdd:COG0514 313 AYYQEIGRAGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVER-AKLDAMLAYAE-TTGCRRQFLLRYFGEELAE 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1052 PdfCKKhpdvsCDNCCKTKdyKTRDVTDDVKSIVRFVqehsssqgmrniKHVGPsgRFTMNMLVDIFLGSKSAKIQS--- 1128
Cdd:COG0514 391 P--CGN-----CDNCLGPP--ETFDGTEAAQKALSCV------------YRTGQ--RFGAGHVIDVLRGSKNEKIRQfgh 447
|
490 500
....*....|....*....|....*
gi 564730687 1129 ---GIFGKGSAYSRHNAERLFKKLI 1150
Cdd:COG0514 448 dklSTYGIGKDLSDKEWRSVIRQLL 472
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
643-1283 |
1.90e-152 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 494.03 E-value: 1.90e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 643 RFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVD 722
Cdd:PLN03137 436 KWSSRNFPWTKKLEVNNKKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQD 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 723 QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQ 802
Cdd:PLN03137 516 QIMNLLQANIPAASLSAGMEWAEQLEILQELSSEYSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAHCVSQ 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 803 WGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKkvafdCLE-- 880
Cdd:PLN03137 596 WGHDFRPDYQGLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTKK-----CLEdi 670
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 881 --WIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDV 958
Cdd:PLN03137 671 dkFIKENHFDECGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQW-SKDEINIICATVAFGMGINKPDV 749
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 959 RFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIM--------MEKDGNHHTR-----ETHFNNLYS 1025
Cdd:PLN03137 750 RFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSDYIRVKHMISqggveqspMAMGYNRMASsgrilETNTENLLR 829
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1026 MVHYCENITECRRIQLLAYFGENgFNPDFCKKhpdvSCDNCCKTKDYKTRDVTDDVKSIVRFVqehsssqgmrniKHVGP 1105
Cdd:PLN03137 830 MVSYCENEVDCRRFLQLVHFGEK-FDSTNCKK----TCDNCSSSKSLIDKDVTEIARQLVELV------------KLTGE 892
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1106 sgRFTMNMLVDIFLGSKSAKIQS------GIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGN--KA 1177
Cdd:PLN03137 893 --RFSSAHILEVYRGSLNQYVKKhrhetlSLHGAGKHLSKGEASRILHYLVTEDILAEDVKKSDLYGSVSSLLKVNesKA 970
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1178 QTVLNGNLKV--DFMETENSSSVKKQKALVAKVSQRE------EMVKKCLGEL----------------TEVCKSLGKvf 1233
Cdd:PLN03137 971 YKLFSGGQTIimRFPSSVKASKPSKFEATPAKGPLTSgkqstlPMATPAQPPVdlnlsailytalrklrTALVKEAGD-- 1048
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 564730687 1234 GVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQ 1283
Cdd:PLN03137 1049 GVMAYHIFGNATLQQISKRIPRTKEELLEINGLGKAKVSKYGDRLLETIE 1098
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
651-858 |
9.18e-148 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 446.97 E-value: 9.18e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 651 HTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSL 730
Cdd:cd18016 1 HSKEMMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 731 DIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQD 810
Cdd:cd18016 81 DIPATYLTGDKTDAEATKIYLQLSKKDPIIKLLYVTPEKISASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRPD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 564730687 811 YKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 858
Cdd:cd18016 161 YKRLNMLRQKFPSVPMMALTATATPRVQKDILNQLKMLRPQVFTMSFN 208
|
|
| BDHCT_assoc |
pfam16204 |
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom ... |
425-647 |
1.12e-132 |
|
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom syndrome-associated DEAD-box helicases in higher eukaryotes. It lies between the BDHCT, and DEAD-box families, pfam08072 and pfam00270.
Pssm-ID: 465065 Cd Length: 223 Bit Score: 407.65 E-value: 1.12e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 425 GSLWRYRPDSLDGPMEGDSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSN 504
Cdd:pfam16204 1 GSVWRCRPDSLGSPVKGDSCPTGNSVKELNFPHLPSNSLSTGECLLTTTPGKTGFSATTKNLSERPLFSSHLQKSFVSSN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 505 WAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAY 584
Cdd:pfam16204 81 WAETPRTEKRNESSYFPGNVLTSTAVKDQNKHTASVNDLEREIQASCDIDNFDIDDFDDDDDWENIMHNLAASKSSTAAY 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564730687 585 QPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSL 647
Cdd:pfam16204 161 QPIKEGGPVKSVSERISSAKTNCLPVASTAQNKNFSESIQNYTDKSAQNLASRNLKHEHFQSL 223
|
|
| DpdF |
NF041063 |
protein DpdF; |
672-1009 |
7.83e-50 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 191.28 E-value: 7.83e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALL---GEDCFILMPTGGGKSLCYQLPACVSP---GVTVVISPLRSLIVDQVQKLTSL-------DIPATYLT 738
Cdd:NF041063 145 QREAVRAALLappGSTLIVNLPTGSGKSLVAQAPALLASrqgGLTLVVVPTVALAIDQERRARELlrragpdLGGPLAWH 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 739 GDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASnrLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLR 818
Cdd:NF041063 225 GGLSAEERAAIRQRI--RDGTQRILFTSPESLTGS--LRPALFDAAEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAGLR 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 819 QKFPSVP-------VMALTATanprvqkdiLTQ-----LKIL-----RPQVFSMSFNRHNLKYYVLPKKPKKVAFDC-LE 880
Cdd:NF041063 301 RSLLRLApsgrpfrTLLLSAT---------LTEstldtLETLfgppgPFIVVSAVQLRPEPAYWVAKCDSEEERRERvLE 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 881 WIRkhH---PYdsgIIYCLSRRECDTMADTLQRDGLAALA-YHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKP 956
Cdd:NF041063 372 ALR--HlprPL---ILYVTKVEDAEAWLQRLRAAGFRRVAlFHGDTPDAERERLIEQW-RENELDIVVATSAFGLGMDKS 445
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 564730687 957 DVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVT---RL--KRLIMMEK 1009
Cdd:NF041063 446 DVRTVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDLDiakSLnrPKLISVEK 503
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
669-841 |
4.10e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 117.34 E-value: 4.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 669 RTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPAC------VSPGVTVVISPLRSLIVDQVQKLTSLDIPATY-----L 737
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGKGLGLkvaslL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 738 TGDKTDSEATNIylqlsKKdpiIKLLYVTPEKICASNRLISTLENLyerKLLarfVIDEAHCVSQWGhdFRQDYKRmnML 817
Cdd:pfam00270 81 GGDSRKEQLEKL-----KG---PDILVGTPGRLLDLLQERKLLKNL---KLL---VLDEAHRLLDMG--FGPDLEE--IL 142
|
170 180
....*....|....*....|....
gi 564730687 818 RQKFPSVPVMALTATAnPRVQKDI 841
Cdd:pfam00270 143 RRLPKKRQILLLSATL-PRNLEDL 165
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
661-841 |
6.08e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.33 E-value: 6.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 661 KKFGLHNFRTNQLEAINAALLGE-DCFILMPTGGGKSLCYQLPA-----CVSPGVTVVISPLRSLIVDQVQKLTSL---- 730
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPAlealkRGKGGRVLVLVPTRELAEQWAEELKKLgpsl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 731 -DIPATYLTGDKTDSEATNIylqlskKDPIIKLLYVTPEKIcasnrLISTLENLYERKLLARFVIDEAHCVSQWGhdFRQ 809
Cdd:smart00487 82 gLKVVGLYGGDSKREQLRKL------ESGKTDILVTTPGRL-----LDLLENDKLSLSNVDLVILDEAHRLLDGG--FGD 148
|
170 180 190
....*....|....*....|....*....|..
gi 564730687 810 DYKRmnMLRQKFPSVPVMALTATANPRVQKDI 841
Cdd:smart00487 149 QLEK--LLKLLPKNVQLLLLSATPPEEIENLL 178
|
|
| BDHCT |
pfam08072 |
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily. |
372-412 |
1.44e-21 |
|
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily.
Pssm-ID: 462356 Cd Length: 41 Bit Score: 88.87 E-value: 1.44e-21
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 564730687 372 LIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLT 412
Cdd:pfam08072 1 LYSVMEEICKLVDTIPIHELKALSCGNELLQQRDIRRKLLA 41
|
|
| HRDC |
smart00341 |
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ... |
1213-1292 |
8.69e-20 |
|
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Pssm-ID: 128635 [Multi-domain] Cd Length: 81 Bit Score: 85.04 E-value: 8.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1213 EMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPA 1292
Cdd:smart00341 2 ERQLRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDSPSEA 81
|
|
| HRDC |
pfam00570 |
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ... |
1216-1282 |
2.19e-11 |
|
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Pssm-ID: 425755 [Multi-domain] Cd Length: 68 Bit Score: 60.63 E-value: 2.19e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564730687 1216 KKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVL 1282
Cdd:pfam00570 2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
657-1143 |
0e+00 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 774.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 657 KIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATY 736
Cdd:TIGR00614 1 KILKKYFGLSSFRPVQLEVINAVLLGRDCFVVMPTGGGKSLCYQLPALYSDGITLVISPLISLMEDQVLQLQALGIPATF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 737 LTGDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASNRLISTLEnlyERKLLARFVIDEAHCVSQWGHDFRQDYKRMNM 816
Cdd:TIGR00614 81 LNSAQTKEQQLNVLTDL--KDGKIKLLYVTPEKISASNRLLQTLE---ERKGITLIAVDEAHCISQWGHDFRPDYKALGS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 817 LRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPkKVAFDCLEWIRKHHPYDSGIIYCL 896
Cdd:TIGR00614 156 LKQKFPNVPVMALTATASPSVREDILRQLNLLNPQIFCTSFDRPNLYYEVRRKTP-KILEDLLRFIRKEFEGKSGIIYCP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 897 SRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWInQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQE 976
Cdd:TIGR00614 235 SRKKVEQVAAELQKLGLAAGAYHAGLEDSARDDVQHKFQ-RDEIQVVVATVAFGMGINKPDVRFVIHYSLPKSMESYYQE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 977 SGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNhhtRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCK 1056
Cdd:TIGR00614 314 SGRAGRDGLPSECHLFYAPADMNRLRRLLMEEPDGN---FRTYKLKLYEMMEYCLNSSTCRRLILLSYFGEKGFNKSFCI 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1057 KHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSSSQGMRNikhvgpsGRFTMNMLVDIFLGSKSAKIQSGIFGKGSA 1136
Cdd:TIGR00614 391 MGTEKCCDNCCKRLDYKTKDVTDKVYDFGPQAQKALSAVGRLN-------QKFGMGYPVDFLRGSNSQKIRDGGFRKHSL 463
|
....*..
gi 564730687 1137 YSRHNAE 1143
Cdd:TIGR00614 464 YGRGKDE 470
|
|
| BLM_N |
pfam16202 |
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate ... |
1-368 |
0e+00 |
|
N-terminal region of Bloom syndrome protein; BLM_N is the very N-terminal region of chordate Bloom syndrome proteins. The exact function is not known.
Pssm-ID: 465064 Cd Length: 370 Bit Score: 570.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1 MAAVPQNNLQEQLERHSARTLNNKLSLSKPKFSGFTFKKKTSSDNNVSVTNVSVAKTPVLRNKDVNVTEDFSFSEPLPNT 80
Cdd:pfam16202 1 MAAVPQNNLQEQLERHSARKLNNKLSLSKPKSSGFTFKKKTSSGNDVSVTSVSVAKTPVLSDKDVNVTEAFSFSEPLPHT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 81 TNQQ-RVKDFFKNAPAGQETQRGGSKSLLPDFLQTPKEVVCTTQNTPTVKKSRDTALKKLEFSSSPDSLSTINDWDDMDD 159
Cdd:pfam16202 81 TNQQtRINDFFKNAPAGQQTKRAGSKPLLPDSSQTPQEVSCTTQVTPAVKKPPDAVFKKLEFSSSFDSFISLNDWDDMDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 160 FDTSETSKSFVTPPQSHFVRVSTAQKSKKGKRNFFKAQLYTTNTVKTDLPPPSSESEQIDLTEEQKDDSEWLSSDVICID 239
Cdd:pfam16202 161 FDTSGNSKAFVTPPRNHFVRVSTAQKSKKSKRNFSKAQLSKANTVKADLTPSSGESKQVDLTKEQLDDSEWLSSDVICID 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 240 DGPIAEVHINEDAQESDSLKTHLEDERDNSEKKKNLEEAELHSTEKVPCIEFDDDDYDTDFVPPSPEE-IISASSSSSKC 318
Cdd:pfam16202 241 DDPISEELINEDTQESHSLKTHLGDERDNSEKKKHLEETELHSVEKSPCVELNEDDYDIDFVPPSPEEeVISSSSSSLKC 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 564730687 319 LSTLKDLDTSDRKEDVLSTSKDLLSKPEKMSMQELNPETSTDCDARQISL 368
Cdd:pfam16202 321 FSMLKDLDTSDKEKDGLSTSEDLLSKPEKMTTQQPDQETSTDCDARQISL 370
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
654-1150 |
0e+00 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 557.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 654 EMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIP 733
Cdd:COG0514 4 DALEVLKRVFGYDSFRPGQEEIIEAVLAGRDALVVMPTGGGKSLCYQLPALLLPGLTLVVSPLIALMKDQVDALRAAGIR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 734 ATYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEkicasnRLIS--TLENLYERKLlARFVIDEAHCVSQWGHDFRQDY 811
Cdd:COG0514 84 AAFLNSSLSAEERREVLRALRAGE--LKLLYVAPE------RLLNprFLELLRRLKI-SLFAIDEAHCISQWGHDFRPDY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 812 KRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPyDSG 891
Cdd:COG0514 155 RRLGELRERLPNVPVLALTATATPRVRADIAEQLGLEDPRVFVGSFDRPNLRLEVVPKPPDDKLAQLLDFLKEHPG-GSG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 892 IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGcQVICATIAFGMGIDKPDVRFVIHASLPKSVE 971
Cdd:COG0514 234 IVYCLSRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEV-DVIVATIAFGMGIDKPDVRFVIHYDLPKSIE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 972 GYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHfNNLYSMVHYCEnITECRRIQLLAYFGENGFN 1051
Cdd:COG0514 313 AYYQEIGRAGRDGLPAEALLLYGPEDVAIQRFFIEQSPPDEERKRVER-AKLDAMLAYAE-TTGCRRQFLLRYFGEELAE 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1052 PdfCKKhpdvsCDNCCKTKdyKTRDVTDDVKSIVRFVqehsssqgmrniKHVGPsgRFTMNMLVDIFLGSKSAKIQS--- 1128
Cdd:COG0514 391 P--CGN-----CDNCLGPP--ETFDGTEAAQKALSCV------------YRTGQ--RFGAGHVIDVLRGSKNEKIRQfgh 447
|
490 500
....*....|....*....|....*
gi 564730687 1129 ---GIFGKGSAYSRHNAERLFKKLI 1150
Cdd:COG0514 448 dklSTYGIGKDLSDKEWRSVIRQLL 472
|
|
| recQ |
TIGR01389 |
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 ... |
655-1285 |
8.22e-155 |
|
ATP-dependent DNA helicase RecQ; The ATP-dependent DNA helicase RecQ of E. coli is about 600 residues long. This model represents bacterial proteins with a high degree of similarity in domain architecture and in primary sequence to E. coli RecQ. The model excludes eukaryotic and archaeal proteins with RecQ-like regions, as well as more distantly related bacterial helicases related to RecQ. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273594 [Multi-domain] Cd Length: 591 Bit Score: 481.11 E-value: 8.22e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 655 MMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPA 734
Cdd:TIGR01389 1 AQQVLKRTFGYDDFRPGQEEIISHVLDGRDVLVVMPTGGGKSLCYQVPALLLKGLTVVISPLISLMKDQVDQLRAAGVAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 735 TYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEKicasnrlistLENLYERKLLAR-----FVIDEAHCVSQWGHDFRQ 809
Cdd:TIGR01389 81 AYLNSTLSAKEQQDIEKALVNGE--LKLLYVAPER----------LEQDYFLNMLQRipialVAVDEAHCVSQWGHDFRP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 810 DYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVafDCLEWIRKHHPyD 889
Cdd:TIGR01389 149 EYQRLGSLAERFPQVPRIALTATADAETRQDIRELLRLADANEFITSFDRPNLRFSVVKKNNKQK--FLLDYLKKHRG-Q 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 890 SGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGcQVICATIAFGMGIDKPDVRFVIHASLPKS 969
Cdd:TIGR01389 226 SGIIYASSRKKVEELAERLESQGISALAYHAGLSNKVRAENQEDFLYDDV-KVMVATNAFGMGIDKPNVRFVIHYDMPGN 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 970 VEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLI-MMEKDGNHHTRETHfnNLYSMVHYCENITeCRRIQLLAYFGEN 1048
Cdd:TIGR01389 305 LESYYQEAGRAGRDGLPAEAILLYSPADIALLKRRIeQSEADDDYKQIERE--KLRAMIAYCETQT-CRRAYILRYFGEN 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1049 GFNPdfCKKhpdvsCDNCckTKDYKTRDVTDDVKSIvrfvqehsssqgMRNIKHVGpsGRFTMNMLVDIFLGSKSAKI-- 1126
Cdd:TIGR01389 382 EVEP--CGN-----CDNC--LDPPKSYDATVEAQKA------------LSCVYRMG--QRFGVGYIIEVLRGSKNDKIlq 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1127 ----QSGIFGKGSAYSRHNAERLFKKLILDKildedlYINANDQAIAYVMLGNKAQTVLNGnlkvdfmETENSSSVKKQK 1202
Cdd:TIGR01389 439 kghdQLSTYGIGKDYTQKEWRSLIDQLIAEG------LLTENDEIYIGLQLTEAARKVLKN-------EVEVLLRPFKVV 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1203 ALVAKVSQRE--EMVKKCLGE-LTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVI 1279
Cdd:TIGR01389 506 AKEKTRVQKNlsVGVDNALFEaLRELRKEQADEQNVPPYVIFSDSTLREMAEKRPATLNALLKIKGVGQNKLDRYGEAFL 585
|
....*.
gi 564730687 1280 SVLQKY 1285
Cdd:TIGR01389 586 EVIREY 591
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
643-1283 |
1.90e-152 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 494.03 E-value: 1.90e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 643 RFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVD 722
Cdd:PLN03137 436 KWSSRNFPWTKKLEVNNKKVFGNHSFRPNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALICPGITLVISPLVSLIQD 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 723 QVQKLTSLDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQ 802
Cdd:PLN03137 516 QIMNLLQANIPAASLSAGMEWAEQLEILQELSSEYSKYKLLYVTPEKVAKSDSLLRHLENLNSRGLLARFVIDEAHCVSQ 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 803 WGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKkvafdCLE-- 880
Cdd:PLN03137 596 WGHDFRPDYQGLGILKQKFPNIPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTKK-----CLEdi 670
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 881 --WIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDV 958
Cdd:PLN03137 671 dkFIKENHFDECGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQW-SKDEINIICATVAFGMGINKPDV 749
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 959 RFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIM--------MEKDGNHHTR-----ETHFNNLYS 1025
Cdd:PLN03137 750 RFVIHHSLPKSIEGYHQECGRAGRDGQRSSCVLYYSYSDYIRVKHMISqggveqspMAMGYNRMASsgrilETNTENLLR 829
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1026 MVHYCENITECRRIQLLAYFGENgFNPDFCKKhpdvSCDNCCKTKDYKTRDVTDDVKSIVRFVqehsssqgmrniKHVGP 1105
Cdd:PLN03137 830 MVSYCENEVDCRRFLQLVHFGEK-FDSTNCKK----TCDNCSSSKSLIDKDVTEIARQLVELV------------KLTGE 892
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1106 sgRFTMNMLVDIFLGSKSAKIQS------GIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQAIAYVMLGN--KA 1177
Cdd:PLN03137 893 --RFSSAHILEVYRGSLNQYVKKhrhetlSLHGAGKHLSKGEASRILHYLVTEDILAEDVKKSDLYGSVSSLLKVNesKA 970
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1178 QTVLNGNLKV--DFMETENSSSVKKQKALVAKVSQRE------EMVKKCLGEL----------------TEVCKSLGKvf 1233
Cdd:PLN03137 971 YKLFSGGQTIimRFPSSVKASKPSKFEATPAKGPLTSgkqstlPMATPAQPPVdlnlsailytalrklrTALVKEAGD-- 1048
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|
gi 564730687 1234 GVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQ 1283
Cdd:PLN03137 1049 GVMAYHIFGNATLQQISKRIPRTKEELLEINGLGKAKVSKYGDRLLETIE 1098
|
|
| DEXHc_RecQ2_BLM |
cd18016 |
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ... |
651-858 |
9.18e-148 |
|
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.
Pssm-ID: 350774 [Multi-domain] Cd Length: 208 Bit Score: 446.97 E-value: 9.18e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 651 HTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSL 730
Cdd:cd18016 1 HSKEMMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 731 DIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQD 810
Cdd:cd18016 81 DIPATYLTGDKTDAEATKIYLQLSKKDPIIKLLYVTPEKISASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRPD 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 564730687 811 YKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 858
Cdd:cd18016 161 YKRLNMLRQKFPSVPMMALTATATPRVQKDILNQLKMLRPQVFTMSFN 208
|
|
| BDHCT_assoc |
pfam16204 |
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom ... |
425-647 |
1.12e-132 |
|
BDHCT-box associated domain on Bloom syndrome protein; This family is found on Bloom syndrome-associated DEAD-box helicases in higher eukaryotes. It lies between the BDHCT, and DEAD-box families, pfam08072 and pfam00270.
Pssm-ID: 465065 Cd Length: 223 Bit Score: 407.65 E-value: 1.12e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 425 GSLWRYRPDSLDGPMEGDSCPTGNSMKELNFSHLPSNSVSPGDCLLTTTLGKTGFSATRKNLFERPLFNTHLQKSFVSSN 504
Cdd:pfam16204 1 GSVWRCRPDSLGSPVKGDSCPTGNSVKELNFPHLPSNSLSTGECLLTTTPGKTGFSATTKNLSERPLFSSHLQKSFVSSN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 505 WAETPRLGKKNESSYFPGNVLTSTAVKDQNKHTASINDLERETQPSYDIDNFDIDDFDDDDDWEDIMHNLAASKSSTAAY 584
Cdd:pfam16204 81 WAETPRTEKRNESSYFPGNVLTSTAVKDQNKHTASVNDLEREIQASCDIDNFDIDDFDDDDDWENIMHNLAASKSSTAAY 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564730687 585 QPIKEGRPIKSVSERLSSAKTDCLPVSSTAQNINFSESIQNYTDKSAQNLASRNLKHERFQSL 647
Cdd:pfam16204 161 QPIKEGGPVKSVSERISSAKTNCLPVASTAQNKNFSESIQNYTDKSAQNLASRNLKHEHFQSL 223
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
656-1285 |
2.23e-120 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 389.46 E-value: 2.23e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 656 MKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPAT 735
Cdd:PRK11057 14 KQVLQETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALVLDGLTLVVSPLISLMKDQVDQLLANGVAAA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 736 YLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEKICASNrlisTLENLYERKlLARFVIDEAHCVSQWGHDFRQDYKRMN 815
Cdd:PRK11057 94 CLNSTQTREQQLEVMAGCRTGQ--IKLLYIAPERLMMDN----FLEHLAHWN-PALLAVDEAHCISQWGHDFRPEYAALG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 816 MLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNRHNLKYYVLPK-KPkkvaFDCLEWIRKHHPYDSGIIY 894
Cdd:PRK11057 167 QLRQRFPTLPFMALTATADDTTRQDIVRLLGLNDPLIQISSFDRPNIRYTLVEKfKP----LDQLMRYVQEQRGKSGIIY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 895 CLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYY 974
Cdd:PRK11057 243 CNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAF-QRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 975 QESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEKDGNHHTRETHfnNLYSMVHYCENITeCRRIQLLAYFGENGFNPdf 1054
Cdd:PRK11057 322 QETGRAGRDGLPAEAMLFYDPADMAWLRRCLEEKPAGQQQDIERH--KLNAMGAFAEAQT-CRRLVLLNYFGEGRQEP-- 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1055 ckkhpdvsCDNCcktkdyktrDVTDDVKSivRFVQEHSSSQGMRNIKHVGPsgRFTMNMLVDIFLGSKSAKIQS------ 1128
Cdd:PRK11057 397 --------CGNC---------DICLDPPK--QYDGLEDAQKALSCIYRVNQ--RFGMGYVVEVLRGANNQRIRDyghdkl 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1129 GIFGKGSAYSRHNAERLFKKLILDKILDEDLYINANDQaiayvmLGNKAQTVLNG--NLKVDFMETENSSSVKKQKalva 1206
Cdd:PRK11057 456 KVYGIGRDKSHEHWVSVIRQLIHLGLVTQNIAQHSALQ------LTEAARPVLRGevSLQLAVPRIVALKPRAMQK---- 525
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564730687 1207 kvSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKY 1285
Cdd:PRK11057 526 --SFGGNYDRKLFAKLRKLRKSIADEENIPPYVVFNDATLIEMAEQMPITASEMLSVNGVGQRKLERFGKPFMALIRAH 602
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
657-858 |
1.26e-96 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 308.31 E-value: 1.26e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 657 KIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATY 736
Cdd:cd17920 2 QILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLLDGVTLVVSPLISLMQDQVDRLQQLGIRAAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 737 LTGDKTDSEATNIYLQLskKDPIIKLLYVTPEKIcASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNM 816
Cdd:cd17920 82 LNSTLSPEEKREVLLRI--KNGQYKLLYVTPERL-LSPDFLELLQRLPERKRLALIVVDEAHCVSQWGHDFRPDYLRLGR 158
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 564730687 817 LRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 858
Cdd:cd17920 159 LRRALPGVPILALTATATPEVREDILKRLGLRNPVIFRASFD 200
|
|
| DEXHc_RecQ1 |
cd18015 |
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ... |
650-858 |
1.30e-83 |
|
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350773 [Multi-domain] Cd Length: 209 Bit Score: 272.32 E-value: 1.30e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 650 PHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTS 729
Cdd:cd18015 1 PWSGKVKDTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPALCSDGFTLVVSPLISLMEDQLMALKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 730 LDIPATYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQ 809
Cdd:cd18015 81 LGISATMLNASSSKEHVKWVHAALTDKNSELKLLYVTPEKIAKSKRFMSKLEKAYNAGRLARIAIDEVHCCSQWGHDFRP 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 564730687 810 DYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 858
Cdd:cd18015 161 DYKKLGILKRQFPNVPILGLTATATSKVLKDVQKILCIQKCLTFTASFN 209
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
859-993 |
1.30e-77 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 252.13 E-value: 1.30e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 859 RHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINqD 938
Cdd:cd18794 1 RPNLFYSVRPKDKKDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLR-D 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 564730687 939 GCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFY 993
Cdd:cd18794 80 KIQVIVATVAFGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILFY 134
|
|
| DEXHc_RecQ4-like |
cd18018 |
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ... |
656-858 |
1.19e-61 |
|
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.
Pssm-ID: 350776 [Multi-domain] Cd Length: 201 Bit Score: 209.42 E-value: 1.19e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 656 MKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACV----SPGVTVVISPLRSLIVDQVQKLTSLd 731
Cdd:cd18018 1 LKLLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLPALLlrrrGPGLTLVVSPLIALMKDQVDALPRA- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 732 IPATYLTGDKTDSEATNIYLQLSKKDpiIKLLYVTPEKICASnrliSTLENLYERKLLARFVIDEAHCVSQWGHDFRQDY 811
Cdd:cd18018 80 IKAAALNSSLTREERRRILEKLRAGE--VKILYVSPERLVNE----SFRELLRQTPPISLLVVDEAHCISEWSHNFRPDY 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 564730687 812 KRM-NMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 858
Cdd:cd18018 154 LRLcRVLRELLGAPPVLALTATATKRVVEDIASHLGIPESGVVRGPLY 201
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
657-850 |
1.10e-60 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 206.55 E-value: 1.10e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 657 KIFHKKFGLHNFRTN-QLEAINAALLGE-DCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPA 734
Cdd:cd18014 2 STLKKVFGHSDFKSPlQEKATMAVVKGNkDVFVCMPTGAGKSLCYQLPALLAKGITIVISPLIALIQDQVDHLKTLKIRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 735 TYLTGDKTDSEATNIYLQLSKKDPIIKLLYVTPEKiCASNRLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRM 814
Cdd:cd18014 82 DSLNSKLSAQERKRIIADLESEKPQTKFLYITPEM-AATSSFQPLLSSLVSRNLLSYLVVDEAHCVSQWGHDFRPDYLRL 160
|
170 180 190
....*....|....*....|....*....|....*.
gi 564730687 815 NMLRQKFPSVPVMALTATANPRVQKDILTQLKILRP 850
Cdd:cd18014 161 GALRSRYGHVPWVALTATATPQVQEDIFAQLRLKKP 196
|
|
| DEXHc_RecQ3 |
cd18017 |
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ... |
663-858 |
4.47e-50 |
|
DEAH-box helicase domain of RecQ3; DEAD-like helicase RecQ3 (also called Werner syndrome ATP-dependent helicase or WRN) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Werner's syndrome.
Pssm-ID: 350775 [Multi-domain] Cd Length: 193 Bit Score: 175.73 E-value: 4.47e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 663 FGLHNFRTNQLEAINAAL-LGEDCFILMPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGDK 741
Cdd:cd18017 8 FGHSSFRPVQWKVIRSVLeERRDNLVVMATGYGKSLCYQYPSVLLNSLTLVISPLISLMEDQVLQLVMSNIPACFLGSAQ 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 742 TDSEATNIylqlskKDPIIKLLYVTPEKICASNRLISTLENlyERKLLArfvIDEAHCVSQWGHDFRQDYKRMNMLRQKF 821
Cdd:cd18017 88 SQNVLDDI------KMGKIRVIYVTPEFVSKGLELLQQLRN--GITLIA---IDEAHCVSQWGHDFRSSYRHLGSIRNRL 156
|
170 180 190
....*....|....*....|....*....|....*..
gi 564730687 822 PSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFN 858
Cdd:cd18017 157 PNVPIVALTATATPSVRDDIIKNLNLRNPQITCTSFD 193
|
|
| DpdF |
NF041063 |
protein DpdF; |
672-1009 |
7.83e-50 |
|
protein DpdF;
Pssm-ID: 468990 [Multi-domain] Cd Length: 813 Bit Score: 191.28 E-value: 7.83e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALL---GEDCFILMPTGGGKSLCYQLPACVSP---GVTVVISPLRSLIVDQVQKLTSL-------DIPATYLT 738
Cdd:NF041063 145 QREAVRAALLappGSTLIVNLPTGSGKSLVAQAPALLASrqgGLTLVVVPTVALAIDQERRARELlrragpdLGGPLAWH 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 739 GDKTDSEATNIYLQLskKDPIIKLLYVTPEKICASnrLISTLENLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLR 818
Cdd:NF041063 225 GGLSAEERAAIRQRI--RDGTQRILFTSPESLTGS--LRPALFDAAEAGLLRYLVVDEAHLVDQWGDGFRPEFQLLAGLR 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 819 QKFPSVP-------VMALTATanprvqkdiLTQ-----LKIL-----RPQVFSMSFNRHNLKYYVLPKKPKKVAFDC-LE 880
Cdd:NF041063 301 RSLLRLApsgrpfrTLLLSAT---------LTEstldtLETLfgppgPFIVVSAVQLRPEPAYWVAKCDSEEERRERvLE 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 881 WIRkhH---PYdsgIIYCLSRRECDTMADTLQRDGLAALA-YHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKP 956
Cdd:NF041063 372 ALR--HlprPL---ILYVTKVEDAEAWLQRLRAAGFRRVAlFHGDTPDAERERLIEQW-RENELDIVVATSAFGLGMDKS 445
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 564730687 957 DVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVT---RL--KRLIMMEK 1009
Cdd:NF041063 446 DVRTVIHACVPETLDRFYQEVGRGGRDGKASLSLLIYTPDDLDiakSLnrPKLISVEK 503
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
669-841 |
4.10e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 117.34 E-value: 4.10e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 669 RTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPAC------VSPGVTVVISPLRSLIVDQVQKLTSLDIPATY-----L 737
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALealdklDNGPQALVLAPTRELAEQIYEELKKLGKGLGLkvaslL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 738 TGDKTDSEATNIylqlsKKdpiIKLLYVTPEKICASNRLISTLENLyerKLLarfVIDEAHCVSQWGhdFRQDYKRmnML 817
Cdd:pfam00270 81 GGDSRKEQLEKL-----KG---PDILVGTPGRLLDLLQERKLLKNL---KLL---VLDEAHRLLDMG--FGPDLEE--IL 142
|
170 180
....*....|....*....|....
gi 564730687 818 RQKFPSVPVMALTATAnPRVQKDI 841
Cdd:pfam00270 143 RRLPKKRQILLLSATL-PRNLEDL 165
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
661-841 |
6.08e-23 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 98.33 E-value: 6.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 661 KKFGLHNFRTNQLEAINAALLGE-DCFILMPTGGGKSLCYQLPA-----CVSPGVTVVISPLRSLIVDQVQKLTSL---- 730
Cdd:smart00487 2 EKFGFEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAALLPAlealkRGKGGRVLVLVPTRELAEQWAEELKKLgpsl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 731 -DIPATYLTGDKTDSEATNIylqlskKDPIIKLLYVTPEKIcasnrLISTLENLYERKLLARFVIDEAHCVSQWGhdFRQ 809
Cdd:smart00487 82 gLKVVGLYGGDSKREQLRKL------ESGKTDILVTTPGRL-----LDLLENDKLSLSNVDLVILDEAHRLLDGG--FGD 148
|
170 180 190
....*....|....*....|....*....|..
gi 564730687 810 DYKRmnMLRQKFPSVPVMALTATANPRVQKDI 841
Cdd:smart00487 149 QLEK--LLKLLPKNVQLLLLSATPPEEIENLL 178
|
|
| RecQ_Zn_bind |
pfam16124 |
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ. |
995-1067 |
3.94e-22 |
|
RecQ zinc-binding; This domain is the zinc-binding domain of ATP-dependent DNA helicase RecQ.
Pssm-ID: 465031 [Multi-domain] Cd Length: 66 Bit Score: 91.20 E-value: 3.94e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 564730687 995 YHDVTRLKRLIMMEkDGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENgFNPDFCKKhpdvsCDNCC 1067
Cdd:pfam16124 1 YQDVVRLRFLIEQS-EADEERKEVELQKLQAMVAYCENTTDCRRKQLLRYFGEE-FDSEPCGN-----CDNCL 66
|
|
| BDHCT |
pfam08072 |
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily. |
372-412 |
1.44e-21 |
|
BDHCT (NUC031) domain; This is a C-terminal domain in Bloom's syndrome DEAD helicase subfamily.
Pssm-ID: 462356 Cd Length: 41 Bit Score: 88.87 E-value: 1.44e-21
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 564730687 372 LIHVMEHICKLIDTIPDDKLKLLDCGNELLQQRNIRRKLLT 412
Cdd:pfam08072 1 LYSVMEEICKLVDTIPIHELKALSCGNELLQQRDIRRKLLA 41
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
902-984 |
5.34e-20 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 85.73 E-value: 5.34e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 902 DTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAG 981
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKF-NNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAG 79
|
...
gi 564730687 982 RDG 984
Cdd:smart00490 80 RAG 82
|
|
| HRDC |
smart00341 |
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the ... |
1213-1292 |
8.69e-20 |
|
Helicase and RNase D C-terminal; Hypothetical role in nucleic acid binding. Mutations in the HRDC domain cause human disease.
Pssm-ID: 128635 [Multi-domain] Cd Length: 81 Bit Score: 85.04 E-value: 8.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1213 EMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTSPA 1292
Cdd:smart00341 2 ERQLRLLRRLRQWRDEIARREDVPPYFVLPDETLIKMAAALPTNVSELLAIDGVGEEKARRYGKDLLAVIQEASDSPSEA 81
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
876-984 |
1.04e-17 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 79.95 E-value: 1.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 876 FDCLEWIRKHHPYDSGIIYCLSRRECDTMAdTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDK 955
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEAEL-LLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDVLVATDVAERGLDL 80
|
90 100
....*....|....*....|....*....
gi 564730687 956 PDVRFVIHASLPKSVEGYYQESGRAGRDG 984
Cdd:pfam00271 81 PDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
682-832 |
2.29e-16 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 77.44 E-value: 2.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 682 GEDCFILMPTGGGKSLCYQLPA-CVS---PGVTVVISPLRSLIVDQ---VQKLTSLDIPATYLTGDKTDSEATNIYLQLS 754
Cdd:cd00046 1 GENVLITAPTGSGKTLAALLAAlLLLlkkGKKVLVLVPTKALALQTaerLRELFGPGIRVAVLVGGSSAEEREKNKLGDA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564730687 755 kkdpiiKLLYVTPEKIcasNRLISTLENLYERKlLARFVIDEAHCVSQWGHDFRQDYKRmnMLRQKFPSVPVMALTAT 832
Cdd:cd00046 81 ------DIIIATPDML---LNLLLREDRLFLKD-LKLIIVDEAHALLIDSRGALILDLA--VRKAGLKNAQVILLSAT 146
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
672-1004 |
3.68e-16 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 82.50 E-value: 3.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALLGEDCFILMPTGGGKSLCYQLPAC--VSPGV-----TVVISPLRSL---IVDQVQKLTS-LDIPATYLTGd 740
Cdd:COG0513 29 QAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLqrLDPSRprapqALILAPTRELalqVAEELRKLAKyLGLRVATVYG- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 741 ktdseATNIYLQ---LSKKDPIIkllyV-TPekicasNRLIstleNLYERKLLA-----RFVIDEAhcvsqwghD----- 806
Cdd:COG0513 108 -----GVSIGRQiraLKRGVDIV----VaTP------GRLL----DLIERGALDlsgveTLVLDEA--------Drmldm 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 807 -FRQDYKR-MNML---RQkfpsvpVMALTATANPRVQKdiLTQlKILR-PQVfsMSFNRHNLK------YYVLPKKPKKv 874
Cdd:COG0513 161 gFIEDIERiLKLLpkeRQ------TLLFSATMPPEIRK--LAK-RYLKnPVR--IEVAPENATaetieqRYYLVDKRDK- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 875 aFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWinQDG-CQVICAT-IAfGMG 952
Cdd:COG0513 229 -LELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAF--RNGkIRVLVATdVA-ARG 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 564730687 953 IDKPDVRFVIHASLPKSVEGYYQESG---RAGRDGEishCLLFYTYHDVTRLKRL 1004
Cdd:COG0513 305 IDIDDVSHVINYDLPEDPEDYVHRIGrtgRAGAEGT---AISLVTPDERRLLRAI 356
|
|
| RQC |
smart00956 |
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix ... |
1076-1181 |
3.18e-15 |
|
This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 214936 [Multi-domain] Cd Length: 92 Bit Score: 72.51 E-value: 3.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1076 DVTDDVKSIVRFVQEHSssqgmrnikhvgpsGRFTMNMLVDIFLGSKSAKI------QSGIFGKGSAYSRHNAERLFKKL 1149
Cdd:smart00956 1 DVTEEAQKLLSCVYRTG--------------QRFGAGHVIDVLRGSKNKKIrqkghdRLSTFGIGKDLSKKEWRRLIRQL 66
|
90 100 110
....*....|....*....|....*....|..
gi 564730687 1150 ILDKILDEDlyinanDQAIAYVMLGNKAQTVL 1181
Cdd:smart00956 67 IAEGYLRED------GGRYPYLKLTEKARPVL 92
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
662-998 |
5.64e-15 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 79.68 E-value: 5.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 662 KFGLHNFrtnQLEAINAALL----GEDCFIL-MPTGGGKS-----LCYQLPAcvsPGVTVVISPLRSLiVDQ-VQKLTSL 730
Cdd:COG1061 78 SFELRPY---QQEALEALLAalerGGGRGLVvAPTGTGKTvlalaLAAELLR---GKRVLVLVPRREL-LEQwAEELRRF 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 731 DiPATYLTGDKTDSEAtniylqlskkdPIIkllyvtpekicasnrlISTLENLYERKLLARF-------VIDEAHcvsqw 803
Cdd:COG1061 151 L-GDPLAGGGKKDSDA-----------PIT----------------VATYQSLARRAHLDELgdrfglvIIDEAH----- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 804 gHDFRQDYKRmnmLRQKFPSVPVMALTATANPRVQKDILTQL----------------KILRPQVF---SMSFNRHNLKY 864
Cdd:COG1061 198 -HAGAPSYRR---ILEAFPAAYRLGLTATPFRSDGREILLFLfdgivyeyslkeaiedGYLAPPEYygiRVDLTDERAEY 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 865 YVL------------PKKPKKVAfdclEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQ 932
Cdd:COG1061 274 DALserlrealaadaERKDKILR----ELLREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILE 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564730687 933 kWINQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDV 998
Cdd:COG1061 350 -AFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYDFVGN 414
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
863-993 |
6.85e-15 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 72.54 E-value: 6.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 863 KYYVLPKKPKKVAfdCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDgCQV 942
Cdd:cd18787 4 LYVVVEEEEKKLL--LLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGK-VRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 564730687 943 ICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCLLFY 993
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| RQC |
pfam09382 |
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a ... |
1072-1187 |
1.18e-14 |
|
RQC domain; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure. The RQC domain, found only in RecQ family enzymes, is a high affinity G4 DNA binding domain.
Pssm-ID: 462780 [Multi-domain] Cd Length: 108 Bit Score: 71.42 E-value: 1.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 1072 YKTRDVTDDVKSIVRFVQEhsssqgMRnikhvgpsGRFTMNMLVDIFLGSKSAKI------QSGIFGKGSAYSRHNAERL 1145
Cdd:pfam09382 2 PETVDVTEEAQKILSCVYR------TG--------QRFGAGHLIDVLRGSKNKKIrqlghdKLSTFGIGKDLSKKEWRRI 67
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 564730687 1146 FKKLILDKILDEDLyinandQAIAYVMLGNKAQTVLNGNLKV 1187
Cdd:pfam09382 68 IRQLIAEGYLEVDI------EFYSVLKLTPKAREVLKGEEKV 103
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
661-987 |
4.06e-14 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 77.57 E-value: 4.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 661 KKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPA----CVSPGVTV-VISPLRSLIVDQVQKLTSL----- 730
Cdd:COG1205 50 KKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVlealLEDPGATAlYLYPTKALARDQLRRLRELaealg 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 731 -DI-PATYlTGDkTDSEAtniylqlskKDPIIK---LLYVTPEKICAS-----NRLISTLENLyerkllaRF-VIDEAHC 799
Cdd:COG1205 130 lGVrVATY-DGD-TPPEE---------RRWIREhpdIVLTNPDMLHYGllphhTRWARFFRNL-------RYvVIDEAHT 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 800 ---V--SQWGHDFRqdykRMNMLRQKFPSVPVMALT-AT-ANPrvqKDILTQLkILRP-QVFSMSFNRHNLKYYVL---P 868
Cdd:COG1205 192 yrgVfgSHVANVLR----RLRRICRHYGSDPQFILAsATiGNP---AEHAERL-TGRPvTVVDEDGSPRGERTFVLwnpP 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 869 KKPKKVAFDCL--------EWIRKHHpydSGIIYCLSRRECDTMADTLQR------DGLAALAYHAGLSDSARDEVQQKW 934
Cdd:COG1205 264 LVDDGIRRSALaeaarllaDLVREGL---RTLVFTRSRRGAELLARYARRalrepdLADRVAAYRAGYLPEERREIERGL 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 564730687 935 inQDG-CQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEIS 987
Cdd:COG1205 341 --RSGeLLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDS 392
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
643-982 |
2.25e-13 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 74.55 E-value: 2.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 643 RFQSLSFPHTKEMMKifhkKFGLHNFRTNQLEAINAALLGEDCFIL-MPTGGGKSLCYQLPAC--VSPGVTVV-ISPLRS 718
Cdd:COG1204 2 KVAELPLEKVIEFLK----ERGIEELYPPQAEALEAGLLEGKNLVVsAPTASGKTLIAELAILkaLLNGGKALyIVPLRA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 719 LIvDQV-----QKLTSLDIPATYLTGDKTDSEAtniylQLSKKDPIIkllyVTPEKicasnrLISTLENlyERKLLARF- 792
Cdd:COG1204 78 LA-SEKyrefkRDFEELGIKVGVSTGDYDSDDE-----WLGRYDILV----ATPEK------LDSLLRN--GPSWLRDVd 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 793 --VIDEAHCVsqwghdfrQDYKR---MNM----LRQKFPSVPVMALTAT-ANPrvqKDIltqLKILRPQVFSMSFNRHNL 862
Cdd:COG1204 140 lvVVDEAHLI--------DDESRgptLEVllarLRRLNPEAQIVALSATiGNA---EEI---AEWLDAELVKSDWRPVPL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 863 KYYVLpkKPKKVAFDC--------LEWIRKHHPYDSG--IIYCLSRRECDTMAD-------------------------- 906
Cdd:COG1204 206 NEGVL--YDGVLRFDDgsrrskdpTLALALDLLEEGGqvLVFVSSRRDAESLAKkladelkrrltpeereeleelaeell 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 907 -----TLQRDGLAAL-----AYH-AGLSDSARDEVQQkWInQDG-CQVICAT--IAfgMGIDKPdVRFVIHASL------ 966
Cdd:COG1204 284 evseeTHTNEKLADClekgvAFHhAGLPSELRRLVED-AF-REGlIKVLVATptLA--AGVNLP-ARRVIIRDTkrggmv 358
|
410
....*....|....*.
gi 564730687 967 PKSVEGYYQESGRAGR 982
Cdd:COG1204 359 PIPVLEFKQMAGRAGR 374
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
672-1009 |
3.25e-12 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 70.97 E-value: 3.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALLGEDCFILMPTGGGKSLCYQLP---ACVS----------PGVTVVISPLRSLIVdQVQ---KLTSLDIP-- 733
Cdd:PLN00206 148 QMQAIPAALSGRSLLVSADTGSGKTASFLVPiisRCCTirsghpseqrNPLAMVLTPTRELCV-QVEdqaKVLGKGLPfk 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 734 -ATYLTGDKTDSeatniylQLSKKDPIIKLLYVTPekicasNRLISTL-ENLYERKLLARFVIDEAHCVSQWGhdFRQdy 811
Cdd:PLN00206 227 tALVVGGDAMPQ-------QLYRIQQGVELIVGTP------GRLIDLLsKHDIELDNVSVLVLDEVDCMLERG--FRD-- 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 812 kRMNMLRQKFPSVPVMALTATANPRVQKDILTQLKilrpQVFSMSF---NR-----HNLKYYVLPKKPKKVAFDCLEwiR 883
Cdd:PLN00206 290 -QVMQIFQALSQPQVLLFSATVSPEVEKFASSLAK----DIILISIgnpNRpnkavKQLAIWVETKQKKQKLFDILK--S 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 884 KHHPYDSGIIYCLSRRECDTMADTLQR-DGLAALAYHAGLSDSARDEVQQKWINQDgCQVICATIAFGMGIDKPDVRFVI 962
Cdd:PLN00206 363 KQHFKPPAVVFVSSRLGADLLANAITVvTGLKALSIHGEKSMKERREVMKSFLVGE-VPVIVATGVLGRGVDLLRVRQVI 441
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 564730687 963 HASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEK 1009
Cdd:PLN00206 442 IFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVALLK 488
|
|
| HRDC |
pfam00570 |
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic ... |
1216-1282 |
2.19e-11 |
|
HRDC domain; The HRDC (Helicase and RNase D C-terminal) domain has a putative role in nucleic acid binding. Mutations in the HRDC domain cause human disease. It is interesting to note that the RecQ helicase in Deinococcus radiodurans has three tandem HRDC domains.
Pssm-ID: 425755 [Multi-domain] Cd Length: 68 Bit Score: 60.63 E-value: 2.19e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564730687 1216 KKCLGELTEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVL 1282
Cdd:pfam00570 2 LALLKALREWRDELAREEDVPPYVIFPDKTLLEIAEKLPRTLEELLAIPGVGPRKVERYGEEILAAI 68
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
672-798 |
8.26e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 59.52 E-value: 8.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALLGEDCFILMPTGGGKSLCYQLP----ACVSPGVT-VVISPLRSLIVDQVQKLTSL------DI-PATYlTG 739
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPileaLLRDPGSRaLYLYPTKALAQDQLRSLRELleqlglGIrVATY-DG 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564730687 740 DKTDSEATNIYLQLSkkdpiiKLLYVTPEKICAS-----NRLISTLENLyerkllaRF-VIDEAH 798
Cdd:cd17923 84 DTPREERRAIIRNPP------RILLTNPDMLHYAllphhDRWARFLRNL-------RYvVLDEAH 135
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
682-798 |
1.59e-09 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 58.36 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 682 GEDCFILMPTGGGKSLCYQLPACVS------PGVTVV-ISPLRSLIVDQVQKLT------SLDIPATYLTGDKTDSEATn 748
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSladepeKGVQVLyISPLKALINDQERRLEepldeiDLEIPVAVRHGDTSQSEKA- 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 564730687 749 iylQLSKKDPIIklLYVTPEKICA---SNRLISTLENLyerkllaRFVI-DEAH 798
Cdd:cd17922 80 ---KQLKNPPGI--LITTPESLELllvNKKLRELFAGL-------RYVVvDEIH 121
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
892-985 |
2.39e-09 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 57.27 E-value: 2.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 892 IIYCLSRRECDTMA----DTLQRDGLAA---LAYHAGLSDSARDEVQQKWINQDGCQVIcATIAFGMGIDKPDVRFVIHA 964
Cdd:cd18797 39 IVFCRSRKLAELLLrylkARLVEEGPLAskvASYRAGYLAEDRREIEAELFNGELLGVV-ATNALELGIDIGGLDAVVLA 117
|
90 100
....*....|....*....|.
gi 564730687 965 SLPKSVEGYYQESGRAGRDGE 985
Cdd:cd18797 118 GYPGSLASLWQQAGRAGRRGK 138
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
892-1014 |
4.53e-08 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 57.98 E-value: 4.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 892 IIYCLSRRECDTMADTLqrdGLAALAYHAGLSDSARDEVQQKWINQDgCQVICATIAFGMGIDKPDVRfVIHASLPK--- 968
Cdd:COG1202 431 IIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKVERRFADQE-LAAVVTTAALAAGVDFPASQ-VIFDSLAMgie 505
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 564730687 969 --SVEGYYQESGRAGRDGeishcllfytYHDvtRLKRLIMMEKDGNHH 1014
Cdd:COG1202 506 wlSVQEFHQMLGRAGRPD----------YHD--RGKVYLLVEPGKSYH 541
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
888-999 |
8.89e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.78 E-value: 8.89e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 888 YDSGIIYCLSRRECDTMADTLQrdglaalayhaglsdsardevqqkwinqdgcqVICATIAFGMGIDKPDVRFVIHASLP 967
Cdd:cd18785 3 VVKIIVFTNSIEHAEEIASSLE--------------------------------ILVATNVLGEGIDVPSLDTVIFFDPP 50
|
90 100 110
....*....|....*....|....*....|..
gi 564730687 968 KSVEGYYQESGRAGRDGEIShcllfYTYHDVT 999
Cdd:cd18785 51 SSAASYIQRVGRAGRGGKDE-----GEVILFV 77
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
672-837 |
9.58e-08 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 53.42 E-value: 9.58e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALLGEDCFIL-MPTGGGKSLCYQLPA----CVSPGVTVVISPLRSLiVDQV-----QKLTSLDIPATYLTGDK 741
Cdd:cd17921 6 QREALRALYLSGDSVLVsAPTSSGKTLIAELAIlralATSGGKAVYIAPTRAL-VNQKeadlrERFGPLGKNVGLLTGDP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 742 TDSeatniYLQLSKKDPIIkllyVTPEKICAsnrLISTLENLYERKLLArFVIDEAHCVSqwghdfrqDYKR-------M 814
Cdd:cd17921 85 SVN-----KLLLAEADILV----ATPEKLDL---LLRNGGERLIQDVRL-VVVDEAHLIG--------DGERgvvlellL 143
|
170 180
....*....|....*....|....
gi 564730687 815 NMLRQKFPSVPVMALTAT-ANPRV 837
Cdd:cd17921 144 SRLLRINKNARFVGLSATlPNAED 167
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
672-1003 |
1.61e-07 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 55.94 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALLGEDCFILMPTGGGKSLCYQLPACV--------SPG---VTVVISPLRSLiVDQvqkltsldIPATYLT-G 739
Cdd:PTZ00110 157 QVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVhinaqpllRYGdgpIVLVLAPTREL-AEQ--------IREQCNKfG 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 740 DKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLE-NLYERKLLARFVIDEAHCVSQWGHDFrQDYKRMNMLR 818
Cdd:PTZ00110 228 ASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLEsNVTNLRRVTYLVLDEADRMLDMGFEP-QIRKIVSQIR 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 819 qkfPSVPVMALTATANPRVQK---DILTQLKIlRPQVFSMSFNR-HNLK--YYVLPKKPKKVAFDCLeWIRKHHPYDSGI 892
Cdd:PTZ00110 307 ---PDRQTLMWSATWPKEVQSlarDLCKEEPV-HVNVGSLDLTAcHNIKqeVFVVEEHEKRGKLKML-LQRIMRDGDKIL 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 893 IYCLSRRECDTMADTLQRDGLAALAYHAglsDSARDEvqQKWINQD----GCQVICATIAFGMGIDKPDVRFVIHASLPK 968
Cdd:PTZ00110 382 IFVETKKGADFLTKELRLDGWPALCIHG---DKKQEE--RTWVLNEfktgKSPIMIATDVASRGLDVKDVKYVINFDFPN 456
|
330 340 350
....*....|....*....|....*....|....*
gi 564730687 969 SVEGYYQESGRAGRDGEISHCLLFYTyHDVTRLKR 1003
Cdd:PTZ00110 457 QIEDYVHRIGRTGRAGAKGASYTFLT-PDKYRLAR 490
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
667-856 |
3.69e-07 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 52.36 E-value: 3.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 667 NFRTNQLEAINAALLGEDCFIL-MPTGGGKSLCYQL--------PACVSPG--VTVVISPLRSLIVDQV----QKLTSLD 731
Cdd:cd18023 1 YFNRIQSEVFPDLLYSDKNFVVsAPTGSGKTVLFELailrllkeRNPLPWGnrKVVYIAPIKALCSEKYddwkEKFGPLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 732 IPATYLTGDkTDSEATNiylQLSKKDPIIkllyVTPEKICASNRLISTLENLYErkLLARFVIDEAHCVSQW-GHDFRQD 810
Cdd:cd18023 81 LSCAELTGD-TEMDDTF---EIQDADIIL----TTPEKWDSMTRRWRDNGNLVQ--LVALVLIDEVHIIKENrGATLEVV 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 564730687 811 YKRMNML-------RQKFPSVPVMALTATAnPRVQkDILTQLKILRPQVFSMS 856
Cdd:cd18023 151 VSRMKTLsssselrGSTVRPMRFVAVSATI-PNIE-DLAEWLGDNPAGCFSFG 201
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
892-1004 |
4.31e-07 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 54.06 E-value: 4.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 892 IIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWiNQDGCQVICATIAFGMGIDKPDVRFVIHASLPKSVE 971
Cdd:PTZ00424 271 IIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREF-RSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPE 349
|
90 100 110
....*....|....*....|....*....|...
gi 564730687 972 GYYQESGRAGRDGEISHCLLFYTYHDVTRLKRL 1004
Cdd:PTZ00424 350 NYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEI 382
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
873-984 |
1.11e-06 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 49.86 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 873 KVAFDCLEWIRKHHPYdsgIIYCLSRRECDTMADTLQrdGLAalAYHAGLSDSARDEV----QQKWInqdgcQVICATIA 948
Cdd:cd18795 31 IIVLLKIETVSEGKPV---LVFCSSRKECEKTAKDLA--GIA--FHHAGLTREDRELVeelfREGLI-----KVLVATST 98
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 564730687 949 FGMGIDKPdVRFVIHASLPKSVEGYYQE---------SGRAGRDG 984
Cdd:cd18795 99 LAAGVNLP-ARTVIIKGTQRYDGKGYRElspleylqmIGRAGRPG 142
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
878-992 |
1.23e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 49.57 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 878 CLEWIRKHhpyDSGIIYCLSRRECDTMADTL------QRDGLAALAYHAGLSDSARDEVQQKWinQDG-CQVICATIAFG 950
Cdd:cd18796 31 VIFLLERH---KSTLVFTNTRSQAERLAQRLrelcpdRVPPDFIALHHGSLSRELREEVEAAL--KRGdLKVVVATSSLE 105
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 564730687 951 MGIDKPDVRFVIHASLPKSVEGYYQESGRAG-RDGEISHCLLF 992
Cdd:cd18796 106 LGIDIGDVDLVIQIGSPKSVARLLQRLGRSGhRPGAASKGRLV 148
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
672-835 |
3.46e-04 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 43.09 E-value: 3.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALL-GEDCFILMPTGGGKSLCYQL---PACVSPGVTVVISPLRSLIVDQV---QKLTSLDIPATYLTGDkTDS 744
Cdd:cd18028 6 QAEAVRAGLLkGENLLISIPTASGKTLIAEMamvNTLLEGGKALYLVPLRALASEKYeefKKLEEIGLKVGISTGD-YDE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 745 EATNiylqLSKKDPIIkllyVTPEKICASNRLISTLENlyerkLLARFVIDEAHCVSqwghdfrqDYKR-------MNML 817
Cdd:cd18028 85 DDEW----LGDYDIIV----ATYEKFDSLLRHSPSWLR-----DVGVVVVDEIHLIS--------DEERgptlesiVARL 143
|
170
....*....|....*....
gi 564730687 818 RQKFPSVPVMALTATA-NP 835
Cdd:cd18028 144 RRLNPNTQIIGLSATIgNP 162
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
668-832 |
4.26e-04 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 43.19 E-value: 4.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 668 FRTNQLEAINAALLGEDCFILMPTGGGKS-----LC----YQLPaCVSPGVTVVISPLRSLIVDQVQKL-TSLDIPAtYL 737
Cdd:cd17927 3 PRNYQLELAQPALKGKNTIICLPTGSGKTfvavlICehhlKKFP-AGRKGKVVFLANKVPLVEQQKEVFrKHFERPG-YK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 738 TGDKTDSEATNIYLQLSKKDPiiKLLYVTPEkICASNRLISTLENLYERKLLarfVIDEAHCVSQwGHDFRQDYKRmnML 817
Cdd:cd17927 81 VTGLSGDTSENVSVEQIVESS--DVIIVTPQ-ILVNDLKSGTIVSLSDFSLL---VFDECHNTTK-NHPYNEIMFR--YL 151
|
170
....*....|....*....
gi 564730687 818 RQKFPSV---P-VMALTAT 832
Cdd:cd17927 152 DQKLGSSgplPqILGLTAS 170
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
888-992 |
1.12e-03 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 43.30 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 888 YDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWinQDG-CQVICATIAFGMGIDKPDVRFVIHASL 966
Cdd:PRK11634 245 FDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERL--KDGrLDILIATDVAARGLDVERISLVVNYDI 322
|
90 100
....*....|....*....|....*.
gi 564730687 967 PKSVEGYYQESGRAGRDGEISHCLLF 992
Cdd:PRK11634 323 PMDSESYVHRIGRTGRAGRAGRALLF 348
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
672-839 |
2.54e-03 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 40.50 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALLGEDCFILMPTGGGKSLCYQLPACV-----------SPGVtVVISPLRSL---IVDQVQKLTS-LDIPATY 736
Cdd:cd00268 17 QAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEkllpepkkkgrGPQA-LVLAPTRELamqIAEVARKLGKgTGLKVAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 737 LTGdktdseATNIYLQLSKKDPIIKLLYVTPEkicasnRListLENLYERKLLAR----FVIDEAhcvsqwghD------ 806
Cdd:cd00268 96 IYG------GAPIKKQIEALKKGPDIVVGTPG------RL---LDLIERGKLDLSnvkyLVLDEA--------Drmldmg 152
|
170 180 190
....*....|....*....|....*....|....*..
gi 564730687 807 FRQD----YKRMNMLRQkfpsvpVMALTATANPRVQK 839
Cdd:cd00268 153 FEEDvekiLSALPKDRQ------TLLFSATLPEEVKE 183
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
684-836 |
2.92e-03 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 40.43 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 684 DCFILM--PTGGGKSLCYQLPAC----VSPGVTVV-ISPLRSLIVDQVQ----KLT-SLDIPATYLTGDKT-DSEAtniy 750
Cdd:cd18022 17 DNNVLLgaPTGSGKTIAAELAMFrafnKYPGSKVVyIAPLKALVRERVDdwkkRFEeKLGKKVVELTGDVTpDMKA---- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 751 lqLSKKDPIIkllyVTPEKICASNRLISTLENLYERKLLarfVIDEAHCV-SQWGHDFRQDYKRMNML-RQKFPSVPVMA 828
Cdd:cd18022 93 --LADADIII----TTPEKWDGISRSWQTREYVQQVSLI---IIDEIHLLgSDRGPVLEVIVSRMNYIsSQTEKPVRLVG 163
|
....*....
gi 564730687 829 L-TATANPR 836
Cdd:cd18022 164 LsTALANAG 172
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
657-739 |
3.49e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 41.83 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 657 KIFHKKFGLHNFRTNQLEAINA---ALL-GEDCFILMPTGGGKSLCYQLPA---CVSPGVTVVIS----PLRSLIVDQ-- 723
Cdd:COG1199 4 GLLALAFPGFEPRPGQREMAEAvarALAeGRHLLIEAGTGTGKTLAYLVPAllaARETGKKVVIStatkALQEQLVEKdl 83
|
90
....*....|....*...
gi 564730687 724 --VQKLTSLDIPATYLTG 739
Cdd:COG1199 84 plLRKALGLPLRVALLKG 101
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
672-849 |
3.77e-03 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 40.26 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 672 QLEAINAALLGEDCFILMPTGGGKSLCYQLP-----------ACVSPGVTVVI-SPLRSLiVDQVQK-LTSL------DI 732
Cdd:cd17961 21 QSKAIPLALEGKDILARARTGSGKTAAYALPiiqkilkakaeSGEEQGTRALIlVPTREL-AQQVSKvLEQLtaycrkDV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 733 PATYLTGDKTDSEATNIylqLSKKDPIIkllyV-TPEKI---CASNRLI--STLENLyerkllarfVIDEAHCVSQWGHD 806
Cdd:cd17961 100 RVVNLSASSSDSVQRAL---LAEKPDIV----VsTPARLlshLESGSLLllSTLKYL---------VIDEADLVLSYGYE 163
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 564730687 807 frqdyKRMNMLRQKFPSVPVMALT-ATANPRVQKdiLTQLkILR 849
Cdd:cd17961 164 -----EDLKSLLSYLPKNYQTFLMsATLSEDVEA--LKKL-VLH 199
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
888-992 |
6.31e-03 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 37.92 E-value: 6.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730687 888 YDSGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDE--VQQKWINQDGCQVICATIAFGMGIDKPDVRFVIHAS 965
Cdd:cd18799 6 EIKTLIFCVSIEHAEFMAEAFNEAGIDAVALNSDYSDRERGDeaLILLFFGELKPPILVTVDLLTTGVDIPEVDNVVFLR 85
|
90 100
....*....|....*....|....*...
gi 564730687 966 LPKSVEGYYQESGRAGR-DGEISHCLLF 992
Cdd:cd18799 86 PTESRTLFLQMLGRGLRlHEGKDFFTIL 113
|
|
| |
