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Conserved domains on  [gi|564730684|ref|NP_001274171|]
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rho GTPase-activating protein 6 isoform 6 [Homo sapiens]

Protein Classification

rho GTPase-activating 6 family protein( domain architecture ID 10138145)

rho GTPase-activating 6 family protein (RhoGAP6-like) such as RhoGAP6, also known as ArhGAP6, which is both a GTPase-activating protein (GAP) with specificity for RhoA and a cytoskeletal protein that promotes actin remodelling, and RhoGAP36 (ArhGAP36) which is a potent antagonist of PKA signaling

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 222-428 1.97e-132

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239841  Cd Length: 206  Bit Score: 391.80  E-value: 1.97e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 222 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 301
Cdd:cd04376    1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 302 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 381
Cdd:cd04376   81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 564730684 382 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04376  161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 222-428 1.97e-132

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 391.80  E-value: 1.97e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 222 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 301
Cdd:cd04376    1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 302 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 381
Cdd:cd04376   81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 564730684 382 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04376  161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 228-418 9.70e-58

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 194.41  E-value: 9.70e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684   228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID-VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684   307 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADdniskdgqevtGNKMTSLNLATIFGPNLLHk 385
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLLR- 148

                          170       180       190
                   ....*....|....*....|....*....|...
gi 564730684   386 qkSSDKEfsvqsSARAEESTAIIAVVQKMIENY 418
Cdd:smart00324 149 --PPDGE-----VASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 231-384 1.67e-56

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 190.06  E-value: 1.67e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684  231 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564730684  310 INTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 384
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 222-428 1.97e-132

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 391.80  E-value: 1.97e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 222 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 301
Cdd:cd04376    1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 302 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 381
Cdd:cd04376   81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 564730684 382 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04376  161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 228-418 9.70e-58

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 194.41  E-value: 9.70e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684   228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID-VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684   307 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADdniskdgqevtGNKMTSLNLATIFGPNLLHk 385
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLLR- 148

                          170       180       190
                   ....*....|....*....|....*....|...
gi 564730684   386 qkSSDKEfsvqsSARAEESTAIIAVVQKMIENY 418
Cdd:smart00324 149 --PPDGE-----VASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 231-384 1.67e-56

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 190.06  E-value: 1.67e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684  231 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 564730684  310 INTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 384
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 231-417 2.05e-55

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 187.89  E-value: 2.05e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 231 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFI 310
Cdd:cd00159    1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 311 NTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQKSS 389
Cdd:cd00159   81 ELAkIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV-----------NKMTASNLAIVFAPTLLRPPDSD 149

                        170       180
                 ....*....|....*....|....*...
gi 564730684 390 DKEFsvqssaraEESTAIIAVVQKMIEN 417
Cdd:cd00159  150 DELL--------EDIKKLNEIVEFLIEN 169
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-432 2.18e-37

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 139.40  E-value: 2.18e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04391   22 VPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 308 AFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL--H 384
Cdd:cd04391  102 AFYSVQGLpSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEK-----------NKMNLWNVAMIMAPNLFppR 170

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 564730684 385 KQKSSDKEfSVQSSARAEESTAIIavVQKMIENYEALFMVPPDLQNEV 432
Cdd:cd04391  171 GKHSKDNE-SLQEEVNMAAGCANI--MRLLIRYQDLLWTVPSFLINQV 215
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 230-418 1.03e-33

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 127.81  E-value: 1.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR-GIDVSLEE-EHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04385   15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdARSVQLREgEYTVHDVADVLKRFLRDLPDPLLTSELHA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 308 AFINTLLLEPE-EQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04385   95 EWIEAAELENKdERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDE-----------NQMSVHNLALVFGPTLFQTD 163

                        170       180       190
                 ....*....|....*....|....*....|..
gi 564730684 387 KssdkefsvQSSARAEEStaiIAVVQKMIENY 418
Cdd:cd04385  164 E--------HSVGQTSHE---VKVIEDLIDNY 184
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 206-428 1.17e-33

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 128.64  E-value: 1.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 206 PAEAQSKKEKArDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVS--LEEEHSVH 283
Cdd:cd04397    4 PLEILVEKFGA-DSTLGVGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVpdLSKENPVQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 284 dVAALLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVA--RHADdniskd 360
Cdd:cd04397   83 -LAALLKKFLRELPDPLLTFKLYRLWISSQKIEdEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSsfSHID------ 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564730684 361 gqEVTGNKMTSLNLATIFGPNLLHKQKSSDKEfsvqssarAEESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04397  156 --EETGSKMDIHNLATVITPNILYSKTDNPNT--------GDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 224-422 8.17e-33

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 125.53  E-value: 8.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 224 NPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTR 303
Cdd:cd04404   17 NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTFLRELPEPLLTF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 304 ELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL 383
Cdd:cd04404   97 DLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ-----------NKMTNSNLAVVFGPNLL 165

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 564730684 384 HKQKssdkefsvqSSARAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04404  166 WAKD---------ASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-382 9.13e-33

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 125.59  E-value: 9.13e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG---IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:cd04395   18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgfdIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564730684 307 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNL 382
Cdd:cd04395   98 PDFIEANRIEdPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV-----------NKMEPRNLAIVFGPTL 163
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-428 5.08e-32

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 124.07  E-value: 5.08e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04375   20 LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNKLSETF 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 310 INTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHaddniskdgqeVTGNKMTSLNLATIFGPNLLHKQKS 388
Cdd:cd04375  100 IAIFqYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAAN-----------SQENQMTATNLAVCLAPSLFHLNTS 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 564730684 389 SdkeFSVQSSARAE---------------ESTAIIAVVQKMIENYEALFMVPPDL 428
Cdd:cd04375  169 R---RENSSPARRMqrkkslgkpdqkelsENKAAHQCLAYMIEECNTLFMVPKEM 220
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 228-400 7.53e-32

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 122.55  E-value: 7.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04377   13 RSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQWLRELPEPLMTFELYE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 308 AFINTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04377   93 NFLRAMeLEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEV-----------NRMSANALAIVFAPCILRCP 161

                        170
                 ....*....|....
gi 564730684 387 KSSDKEFSVQSSAR 400
Cdd:cd04377  162 DTADPLQSLQDVSK 175
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-422 1.04e-29

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 116.35  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSL-----EEEHSVHDVAALLKEFLRDMPDPLLTRE 304
Cdd:cd04398   16 VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLlispeDYESDIHSVASLLKLFFRELPEPLLTKA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 305 LYTAFINTLLLEPEEQL-GTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL 383
Cdd:cd04398   96 LSREFIEAAKIEDESRRrDALHGLINDLPDANYATLRALMFHLARIKEHESV-----------NRMSVNNLAIIWGPTLM 164

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 564730684 384 HkqkssdkefsvQSSARAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04398  165 N-----------AAPDNAADMSFQSRVIETLLDNAYQIF 192
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-384 1.95e-29

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 115.64  E-value: 1.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04393   20 VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLFLQELPEGLIPASLQIRL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 564730684 310 INTL--LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLH 384
Cdd:cd04393  100 MQLYqdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENR-----------MTAENLAAVFGPDVFH 165
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 225-425 4.77e-29

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 114.88  E-value: 4.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 225 PIYRQVPRLVDSCCQHLEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVsLEEEHSVhDVAALLKEFLRDMPDPLLTRE 304
Cdd:cd04394   15 PEYGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGEAC-LSSALPC-DVAGLLKQFFRELPEPLLPYD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 305 LYTAFINTLLLEPEEQLGTLQLLIY-LLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL 383
Cdd:cd04394   92 LHEALLKAQELPTDEERKSATLLLTcLLPDEHVNTLRYFFSFLYDVAQRCSE-----------NKMDSSNLAVIFAPNLF 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 564730684 384 HkqkSSDKEFSVQSSarAEESTAI-IAVVQKMIENYEALFMVP 425
Cdd:cd04394  161 Q---SEEGGEKMSSS--TEKRLRLqAAVVQTLIDNASNIGIVP 198
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 228-422 2.47e-28

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 112.94  E-value: 2.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG-IDVSLEEEHS-VHDVAALLKEFLRDMPDPLLTREL 305
Cdd:cd04386   18 REIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEFYSdPHAVASALKSYLRELPDPLLTYNL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 306 YTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLh 384
Cdd:cd04386   98 YEDWVQAANKPdEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDE-----------NKMSPSNIAIVLAPNLL- 165

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 564730684 385 kqksSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04386  166 ----WAKNEGSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-422 5.29e-28

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 111.62  E-value: 5.29e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEhSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04402   15 LPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAE-PVLLLASVLKDFLRNIPGSLLSSDLYEEW 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 310 INTLLLEPEEQ-LGTLQLLIYLLPPCNcdtlHRLLQFLsIVARHaddNISKDGQEvtgNKMTSLNLATIFGPNLLHKQKS 388
Cdd:cd04402   94 MSALDQENEEEkIAELQRLLDKLPRPN----VLLLKHL-ICVLH---NISQNSET---NKMDAFNLAVCIAPSLLWPPAS 162

                        170       180       190
                 ....*....|....*....|....*....|....
gi 564730684 389 SDKEfsvqssarAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04402  163 SELQ--------NEDLKKVTSLVQFLIENCQEIF 188
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 230-389 5.58e-27

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 108.63  E-value: 5.58e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLR--EEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04403   16 VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRfaVDHDEKLDLDDSKWEDIHVITGALKLFFRELPEPLFPYSLFN 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 308 AFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04403   96 DFVAAIKLsDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEK-----------NRMTTQNLAIVFGPTLLRPE 164


                 ...
gi 564730684 387 KSS 389
Cdd:cd04403  165 QET 167
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 226-383 7.15e-27

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 109.42  E-value: 7.15e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 226 IYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDV--SLEEE-HSVHDVAALLKEFLRDMPDPLLT 302
Cdd:cd04396   28 VYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYgkSFDWDgYTVHDAASVLRRYLNNLPEPLVP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 303 RELYTAFINTLLLEP------------------EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqev 364
Cdd:cd04396  108 LDLYEEFRNPLRKRPrilqymkgrineplntdiDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNL------- 180

                        170
                 ....*....|....*....
gi 564730684 365 tgnkMTSLNLATIFGPNLL 383
Cdd:cd04396  181 ----MTASNLAAIFQPGIL 195
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 228-422 1.60e-26

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 107.53  E-value: 1.60e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04390   20 RLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 308 AFI---NTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLh 384
Cdd:cd04390  100 DFLscaQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSV-----------NKMSVQNLATVFGPNIL- 167

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 564730684 385 KQKSSDKEfsvqssARAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04390  168 RPKVEDPA------TIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 229-422 4.75e-25

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 103.37  E-value: 4.75e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 229 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG---IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTREL 305
Cdd:cd04372   15 QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDgekADISATVYPDINVITGALKLYFRDLPIPVITYDT 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 306 YTAFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 384
Cdd:cd04372   95 YPKFIDAAKIsNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKD-----------NKMNAENLGIVFGPTLMR 163

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 564730684 385 KQKSSdkefsvqSSARAEESTAIIAVVQKMIENYEALF 422
Cdd:cd04372  164 PPEDS-------ALTTLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 230-397 1.39e-24

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 102.12  E-value: 1.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04378   16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 310 I---NTLLLEPEEQLG------------TLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNL 374
Cdd:cd04378   96 IalaKEIQRDTEEDKApntpievnriirKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE-----------NKMSPNNL 164

                        170       180
                 ....*....|....*....|...
gi 564730684 375 ATIFGPNLLhKQKSSDKEFSVQS 397
Cdd:cd04378  165 GIVFGPTLI-RPRPGDADVSLSS 186
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 228-382 2.92e-24

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 100.90  E-value: 2.92e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHG-LQTVGIFRVGSSKKRVRQLREEFDRGIDVSL---EEEHSVHDVAALLKEFLRDMPDPLLTR 303
Cdd:cd04400   20 RDLPSVVYRCIEYLDKNRaIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfssSLYPDVHTVAGLLKLYLRELPTLILGG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 304 ELYTAF--INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPN 381
Cdd:cd04400  100 ELHNDFkrLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDV-----------NKMNLRNVCIVFSPT 168


                 .
gi 564730684 382 L 382
Cdd:cd04400  169 L 169
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 241-432 6.12e-24

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 100.61  E-value: 6.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 241 LEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEE-EHSVHDVAALLKEFLRDMPDPLLTRELYTAFI--------- 310
Cdd:cd04392   20 LEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESgGFHAHDCATVLKGFLGELPEPLLTHAHYPAHLqiadlcqfd 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 311 ----NTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04392   99 ekgnKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDK-----------NKMSADNLALLFTPHLICPR 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 564730684 387 KssdkefsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEV 432
Cdd:cd04392  168 N-------LTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDA 206
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 230-427 6.41e-24

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 100.06  E-value: 6.41e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04382   17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEF 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 310 IN-TLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARhaddniSKDgqevtgNKMTSLNLATIFGPNLL-HKQK 387
Cdd:cd04382   97 MEaAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ------SPE------CKMDINNLARVFGPTIVgYSVP 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 564730684 388 SSDKEFSVQssaraeestaiIAVVQKMIenYEALFMVPPD 427
Cdd:cd04382  165 NPDPMTILQ-----------DTVRQPRV--VERLLEIPSD 191
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 230-400 7.86e-24

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 99.30  E-value: 7.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04407   15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYNDF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 310 INTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADdniskdgqevtGNKMTSLNLATIFGPNLLHKQKS 388
Cdd:cd04407   95 LRAVELpEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEED-----------VNRMSPNALAIVFAPCLLRCPDS 163

                        170
                 ....*....|..
gi 564730684 389 SDKEFSVQSSAR 400
Cdd:cd04407  164 SDPLTSMKDVAK 175
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 229-390 8.92e-23

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 96.81  E-value: 8.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 229 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTA 308
Cdd:cd04408   15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 309 FI---NTLLLEPEEQLGT----------LQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLA 375
Cdd:cd04408   95 FIalaKELQRDSEKAAESpsiveniirsLKELLGRLPVSNYNTLRHLMAHLYRVAERFED-----------NKMSPNNLG 163

                        170
                 ....*....|....*
gi 564730684 376 TIFGPNLLHKQKSSD 390
Cdd:cd04408  164 IVFGPTLLRPLVGGD 178
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-394 1.11e-22

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 96.42  E-value: 1.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTvGIFRVGSSKKRVRQLREEFDRGIDVSLEEE---HSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:cd04384   18 VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPDLTKDvyiQDIHSVSSLCKLYFRELPNPLLTYQLY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 307 TAFINTLLLEP-EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHaddniskdgQEVTGnkMTSLNLATIFGPNLLHK 385
Cdd:cd04384   97 EKFSEAVSAASdEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKY---------CSITN--MHAKNLAIVWAPNLLRS 165


                 ....*....
gi 564730684 386 QKSSDKEFS 394
Cdd:cd04384  166 KQIESACFS 174
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 230-384 2.85e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 92.10  E-value: 2.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDvSLEEEHSVHD---VAALLKEFLRDMPDPLLTRELY 306
Cdd:cd04383   18 IPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGED-PLADDQNDHDinsVAGVLKLYFRGLENPLFPKERF 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564730684 307 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLH 384
Cdd:cd04383   97 EDLMSCVKLEnPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENM-----------MDPYNLAICFGPTLMP 164
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 228-416 1.79e-20

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 90.22  E-value: 1.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG-IDVSLEEEH--SVHDVAALLKEFLRDMPDPLLTRE 304
Cdd:cd04379   16 RDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNsAAVELSEELypDINVITGVLKDYLRELPEPLITPQ 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 305 LYTAFINTLLLEPE---EQLGTLQL-LIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGP 380
Cdd:cd04379   96 LYEMVLEALAVALPndvQTNTHLTLsIIDCLPLSAKATLLLLLDHLSLVLSNSER-----------NKMTPQNLAVCFGP 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 564730684 381 NLL-HKQKSSDKEFSVQSSARAEESTAI---IAVVQKMIE 416
Cdd:cd04379  165 VLMfCSQEFSRYGISPTSKMAAVSTVDFkqhIEVLHYLLQ 204
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 229-382 1.21e-19

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 87.11  E-value: 1.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 229 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEeHSVHDVAALLKEFLRDMPDPLLTRELYTA 308
Cdd:cd04381   19 DLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEE-YEPPTVASLLKQYLRELPEPLLTKELMPR 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 564730684 309 FINTLLLEPE-EQLGTLQLLIYLLPPCNcdtlhRLLqfLSIVARHADDNISKDGQevtgNKMTSLNLATIFGPNL 382
Cdd:cd04381   98 FEEACGRPTEaEREQELQRLLKELPECN-----RLL--LAWLIVHMDHVIAQELE----TKMNIQNISIVLSPTV 161
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 228-410 1.62e-19

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 86.98  E-value: 1.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 307
Cdd:cd04406   13 RSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 308 AFINTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARhaddniskdgQEVTgNKMTSLNLATIFGPNLLHKQ 386
Cdd:cd04406   93 EFLRAMgLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIAL----------QEET-NRMSANALAIVFAPCILRCP 161

                        170       180
                 ....*....|....*....|....
gi 564730684 387 KSSDKEFSVQSSARAEESTAIIAV 410
Cdd:cd04406  162 DTTDPLQSVQDISKTTTCVELIVC 185
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 229-391 2.14e-19

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 86.91  E-value: 2.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 229 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFD---RGIDVSLeEEHSVHDVAALLKEFLRDMPDPLLTREL 305
Cdd:cd04387   15 KVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDtnnKDVSVML-SEMDVNAIAGTLKLYFRELPEPLFTDEL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 306 YTAFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVArhaddniskDGQEVtgNKMTSLNLATIFGPNLLH 384
Cdd:cd04387   94 YPNFAEGIALsDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVA---------EREEV--NKMSLHNLATVFGPTLLR 162


                 ....*..
gi 564730684 385 KQKSSDK 391
Cdd:cd04387  163 PSEKESK 169
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 234-417 7.34e-19

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 85.52  E-value: 7.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 234 VDSCCQHLEKHGLQTVGIFRVGSSKKRVRQL------REEFDRGiDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:cd04374   32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLlslgldPKTSTPG-DVDLDnSEWEIKTITSALKTYLRNLPEPLMTYELH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 307 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHK 385
Cdd:cd04374  111 NDFINAAKSEnLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKK-----------NLMTVSNLGVVFGPTLLRP 179

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 564730684 386 QkssdkefsvqssaraEESTAIIA-------VVQKMIEN 417
Cdd:cd04374  180 Q---------------EETVAAIMdikfqniVVEILIEN 203
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 228-394 5.34e-17

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 79.81  E-value: 5.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEE-EHSVHDVAALLKEFLRDMPDPLLTRELY 306
Cdd:cd04373   13 KPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSkDFTVNAVAGALKSFFSELPDPLIPYSMH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 307 TAFINTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLHK 385
Cdd:cd04373   93 LELVEAAkINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNL-----------MTSENLSICFWPTLMRP 161


                 ....*....
gi 564730684 386 QKSSDKEFS 394
Cdd:cd04373  162 DFTSMEALS 170
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 230-397 9.21e-17

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 79.85  E-value: 9.21e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 230 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 309
Cdd:cd04409   16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 310 I-------------NTLLLEPEEQLGT----------LQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtg 366
Cdd:cd04409   96 IglakesqhvnetqEAKKNSDKKWPNMctelnrillkSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEE----------- 164

                        170       180       190
                 ....*....|....*....|....*....|.
gi 564730684 367 NKMTSLNLATIFGPNLLhKQKSSDKEFSVQS 397
Cdd:cd04409  165 NKMSASNLGIIFGPTLI-RPRPTDATVSLSS 194
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 227-383 1.26e-15

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 75.89  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 227 YRQVPRLVDSCCQH-LEKHGLQTVGIFRVGSSKKRVRQLREEFDRGiDVSLEEEHSVHDVAALLKEFLRDMPDPLLTREL 305
Cdd:cd04389   18 ELKLPWILTFLSEKvLALGGFQTEGIFRVPGDIDEVNELKLRVDQW-DYPLSGLEDPHVPASLLKLWLRELEEPLIPDAL 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564730684 306 YTAFINTlLLEPEEQLGTLQlliyLLPPCNCDTLHRLLQFLSIVARHAddNISKdgqevtgNKMTSLNLATIFGPNLL 383
Cdd:cd04389   97 YQQCISA-SEDPDKAVEIVQ----KLPIINRLVLCYLINFLQVFAQPE--NVAH-------TKMDVSNLAMVFAPNIL 160
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 218-389 3.82e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 54.65  E-value: 3.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 218 DKKLSLNPIYRQVP--------RLVDsccqHLEKHGLQTVGIFR----VGSSKKRVRQLREEFDRGIDVSLEeeHSVHDV 285
Cdd:cd04380   34 QLELGDNPDYSEVPlsipkeiwRLVD----YLYTRGLAQEGLFEepglPSEPGELLAEIRDALDTGSPFNSP--GSAESV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 286 AALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQlgtLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevt 365
Cdd:cd04380  108 AEALLLFLESLPDPIIPYSLYERLLEAVANNEEDK---RQVIRISLPPVHRNVFVYLCSFLRELLSESAD---------- 174

                        170       180
                 ....*....|....*....|....
gi 564730684 366 gNKMTSLNLATIFGPNLLHKQKSS 389
Cdd:cd04380  175 -RGLDENTLATIFGRVLLRDPPRA 197
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 241-426 7.12e-05

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 44.48  E-value: 7.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 241 LEKHGLQTVGIFRVGSSKKR--VRQLREEFDRGIDVsleEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFIN--TLLLE 316
Cdd:cd04388   26 IEKKGLESSTLYRTQSSSSLteLRQILDCDAASVDL---EQFDVAALADALKRYLLDLPNPVIPAPVYSEMISraQEVQS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 317 PEEQLGTLQLLIY--LLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLhkqkssdkEFS 394
Cdd:cd04388  103 SDEYAQLLRKLIRspNLPHQYWLTLQYLLKHFFRLCQSSSKNL-----------LSARALAEIFSPLLF--------RFQ 163

                        170       180       190
                 ....*....|....*....|....*....|...
gi 564730684 395 VQSSARAEESTAIIAV-VQKMIENYEALFMVPP 426
Cdd:cd04388  164 PASSDSPEFHIRIIEVlITSEWNERQAAPALPP 196
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 295-350 1.90e-03

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 40.78  E-value: 1.90e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 295 DMPDPLLTRELYTAFINTL-LLEP---EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVA 350
Cdd:cd04405  118 QLKEPLLTFHLFDIFVGILeLLGNgkeEVALEALQLCLLLLPPASRRELRRLLRFMARAA 177
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 228-339 4.27e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 39.24  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730684 228 RQVPRLVDSCCQHLEKHGLQTVG------IFRVGSSKKRVRQLREEFDRGIDVSLEEEHS----VHDVAALLKEFLRDMP 297
Cdd:cd04399   14 KVVPLIVSAILSYLDQLYPDLINdevrrnVWTDPVSLKETHQLRNLLNKPKKPDKEVIILkkfePSTVASVLKLYLLELP 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 564730684 298 DPLLT-------RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTL 339
Cdd:cd04399   94 DSLIPhdiydliRSLYSAYPPSQEDSDTARIQGLQSTLSQLPKSHIATL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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