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Conserved domains on  [gi|55925233|ref|NP_001007338|]
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histone-lysine N-methyltransferase KMT5B [Danio rerio]

Protein Classification

SET domain-containing protein( domain architecture ID 14442917)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_KMT5B cd19184
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) ...
 167-310 3.78e-99

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins; KMT5B (also termed lysine N-methyltransferase 5B, lysine-specific methyltransferase 5B, suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1 or Suv4-20h1) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


:

Pssm-ID: 380961  Cd Length: 144  Bit Score: 303.49  E-value: 3.78e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 167 DSGFEILSCNRYSSEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 246
Cdd:cd19184   1 DSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55925233 247 NHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSK 310
Cdd:cd19184  81 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 144
 
Name Accession Description Interval E-value
SET_KMT5B cd19184
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) ...
 167-310 3.78e-99

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins; KMT5B (also termed lysine N-methyltransferase 5B, lysine-specific methyltransferase 5B, suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1 or Suv4-20h1) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380961  Cd Length: 144  Bit Score: 303.49  E-value: 3.78e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 167 DSGFEILSCNRYSSEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 246
Cdd:cd19184   1 DSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55925233 247 NHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSK 310
Cdd:cd19184  81 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 144
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 178-289 1.31e-18

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 82.38  E-value: 1.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233    178 YSSEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERM--LLRHGENDFSVMYSTRKNC--AQLWLGPAAFINHDCRPN 253
Cdd:smart00317   6 FKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPkaYDTDGAKAFYLFDIDSDLCidARRKGNLARFINHSCEPN 85

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 55925233    254 CKFVSTGRDT---ACVKVLRDIEPGEEISCYYGDGFFGE 289
Cdd:smart00317  86 CELLFVEVNGddrIVIFALRDIKPGEELTIDYGSDYANE 124
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
189-304 4.84e-15

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 72.69  E-value: 4.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 189 ATKDWKRNDKIEHLVGciaELSPSEERMLLRHGENDFSVMY----STRKNCAQLWLGPAAFINHDCRPNCKFVsTGRDTA 264
Cdd:COG2940  22 ATRDIPKGTLIGEYPG---EVITWAEAERREPHKEPLHTYLfeldDDGVIDGALGGNPARFINHSCDPNCEAD-EEDGRI 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 55925233 265 CVKVLRDIEPGEEISCYYGDGFFGENNEfCECYTCerRGT 304
Cdd:COG2940  98 FIVALRDIAAGEELTYDYGLDYDEEEYP-CRCPNC--RGT 134
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 187-283 1.14e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 67.93  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233   187 IVATKDWKRNDKIEHLVGCI---------AELSPSEERMLLRHGENDFSV---MYSTRKNCAQLWLGPAAFINHDCRPNC 254
Cdd:pfam00856   4 LFATEDIPKGEFIGEYVEVLlitkeeadkRELLYYDKLELRLWGPYLFTLdedSEYCIDARALYYGNWARFINHSCDPNC 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 55925233   255 K---FVSTGRDTACVKVLRDIEPGEEISCYYG 283
Cdd:pfam00856  84 EvrvVYVNGGPRIVIFALRDIKPGEELTIDYG 115
 
Name Accession Description Interval E-value
SET_KMT5B cd19184
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) ...
 167-310 3.78e-99

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins; KMT5B (also termed lysine N-methyltransferase 5B, lysine-specific methyltransferase 5B, suppressor of variegation 4-20 homolog 1, Su(var)4-20 homolog 1 or Suv4-20h1) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380961  Cd Length: 144  Bit Score: 303.49  E-value: 3.78e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 167 DSGFEILSCNRYSSEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 246
Cdd:cd19184   1 DSGFEILPCNRYSSEQNGAKIVATKEWKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 55925233 247 NHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSK 310
Cdd:cd19184  81 NHDCRPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFKSR 144
SET_Suv4-20 cd19186
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 167-307 4.72e-92

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation.


Pssm-ID: 380963  Cd Length: 142  Bit Score: 285.12  E-value: 4.72e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 167 DSGFEILSCNRYSSE-QNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERMLLRHGENDFSVMYSTRKNCAQLWLGPAAF 245
Cdd:cd19186   1 ESGFEIQPCHRYSLEgQMGAKIVATKKWKKNEKIPLLVGCIAELTEEEEAQLLRPGENDFSVMYSCRKNCAQLWLGPAAF 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55925233 246 INHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAF 307
Cdd:cd19186  81 INHDCRPNCKFVSTGRDTACVQVLRDIEPGEEITCFYGEDFFGDNNCYCECETCERRQTGAF 142
SET_KMT5C cd19185
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...
 167-308 2.24e-87

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380962  Cd Length: 142  Bit Score: 272.68  E-value: 2.24e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 167 DSGFEILSCNRYSSEQNGAKIVATKDWKRNDKIEHLVGCIAELSpSEERMLLRHGENDFSVMYSTRKNCAQLWLGPAAFI 246
Cdd:cd19185   2 ESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELR-EEDEGLLRAGENDFSIMYSTRKRSAQLWLGPAAFI 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55925233 247 NHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFK 308
Cdd:cd19185  81 NHDCKPNCKFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECHTCERKGEGAFR 142
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 167-307 4.13e-81

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 256.05  E-value: 4.13e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 167 DSGFEILSCNRYSSE-QNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERmLLRHGENDFSVMYSTRKNCAQLWLGPAAF 245
Cdd:cd10524   1 DSGFTICPCNRYSLEnHYGAKIIATKPIKKGEKIHELCGCIAELSEEEEA-LLRPGGNDFSVMYSSRKKCSQLWLGPAAF 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55925233 246 INHDCRPNCKFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAF 307
Cdd:cd10524  80 INHDCRPNCKFVPTGKSTACVKVLRDIEPGEEITVYYGDNYFGENNEECECETCERRGRGAF 141
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 178-289 1.31e-18

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 82.38  E-value: 1.31e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233    178 YSSEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERM--LLRHGENDFSVMYSTRKNC--AQLWLGPAAFINHDCRPN 253
Cdd:smart00317   6 FKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPkaYDTDGAKAFYLFDIDSDLCidARRKGNLARFINHSCEPN 85

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 55925233    254 CKFVSTGRDT---ACVKVLRDIEPGEEISCYYGDGFFGE 289
Cdd:smart00317  86 CELLFVEVNGddrIVIFALRDIKPGEELTIDYGSDYANE 124
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
189-304 4.84e-15

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 72.69  E-value: 4.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 189 ATKDWKRNDKIEHLVGciaELSPSEERMLLRHGENDFSVMY----STRKNCAQLWLGPAAFINHDCRPNCKFVsTGRDTA 264
Cdd:COG2940  22 ATRDIPKGTLIGEYPG---EVITWAEAERREPHKEPLHTYLfeldDDGVIDGALGGNPARFINHSCDPNCEAD-EEDGRI 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 55925233 265 CVKVLRDIEPGEEISCYYGDGFFGENNEfCECYTCerRGT 304
Cdd:COG2940  98 FIVALRDIAAGEELTYDYGLDYDEEEYP-CRCPNC--RGT 134
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 187-283 1.14e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 67.93  E-value: 1.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233   187 IVATKDWKRNDKIEHLVGCI---------AELSPSEERMLLRHGENDFSV---MYSTRKNCAQLWLGPAAFINHDCRPNC 254
Cdd:pfam00856   4 LFATEDIPKGEFIGEYVEVLlitkeeadkRELLYYDKLELRLWGPYLFTLdedSEYCIDARALYYGNWARFINHSCDPNC 83

                          90       100       110
                  ....*....|....*....|....*....|..
gi 55925233   255 K---FVSTGRDTACVKVLRDIEPGEEISCYYG 283
Cdd:pfam00856  84 EvrvVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 239-283 2.96e-12

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 62.65  E-value: 2.96e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 55925233 239 WLGPAAFINHDCRPNCKFVST---GRDTACVKVLRDIEPGEEISCYYG 283
Cdd:cd08161  25 VIGLARFINHSCEPNCEFEEVyvgGKPRVFIVALRDIKAGEELTVDYG 72
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 177-301 1.21e-11

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 62.40  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 177 RYSSEQNGAKIVATKDWKRNDKIehlvgciaelspSEERMLLRHGENDFSVMYSTRKNCAQLWLGpAAFINHDCRPNCKF 256
Cdd:cd20071   3 RESEGSKGRGLVATRDIEPGELI------------LVEKPLVSVPSNSFSLTDGLNEIGVGLFPL-ASLLNHSCDPNAVV 69

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 55925233 257 VSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNE--------FCECyTCER 301
Cdd:cd20071  70 VFDGNGTLRVRALRDIKAGEELTISYIDPLLPRTERrrellekyGFTC-SCPR 121
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 181-296 7.39e-08

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 51.87  E-value: 7.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 181 EQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERM--LLRHGENDFSVMY--------STRK-NCAQlwlgpaaFINHD 249
Cdd:cd10531   8 EKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLdeYEELGKSNFYILSlsddvvidATRKgNLSR-------FINHS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 55925233 250 CRPNCKfvsTGRDTACVKV------LRDIEPGEEISCYYGDGFFGENNEFCEC 296
Cdd:cd10531  81 CEPNCE---TQKWIVNGEYrigifaLRDIPAGEELTFDYNFVNYNEAKQVCLC 130
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 180-303 1.25e-06

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 48.57  E-value: 1.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 180 SEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERML-LRH-GENDFSVMYSTRKNC--AQLWLGPAAFINHDCRPNC- 254
Cdd:cd19175   7 TEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWdMKHkGEKNFYMCEIDKDMVidATFKGNLSRFINHSCDPNCe 86

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 55925233 255 --KFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEfCECYTCERRG 303
Cdd:cd19175  87 lqKWQVDGETRIGVFAIRDIKKGEELTYDYQFVQFGADQD-CHCGSKNCRG 136
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 179-284 2.45e-06

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 46.86  E-value: 2.45e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 179 SSEQNGAKIVATKDWKRNDKIEhLVGCIaeLSPSEERMLLRHGENDFSVmYSTRKNCAQLWLGPAAFINHDCRPNCKFV- 257
Cdd:cd10540   6 PSTLKGRGVFATRPIKKGEVIE-EAPVI--VLPKEEYQHLCKTVLDHYV-FSWGDGCLALALGYGSMFNHSYTPNAEYEi 81

                        90       100
                ....*....|....*....|....*..
gi 55925233 258 STGRDTACVKVLRDIEPGEEISCYYGD 284
Cdd:cd10540  82 DFENQTIVFYALRDIEAGEELTINYGD 108
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 180-296 3.60e-06

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 47.29  E-value: 3.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 180 SEQNGAKIVATKDWKRNDKIEHLVGciaELSPSEE-RMLLRHG-ENDFSVMYSTRKNCAQLW-LGP----AAFINHDCRP 252
Cdd:cd19211   9 TEGKGWGLIAKRDIKKGEFVNEYVG---ELIDEEEcMARIKHAhENDITHFYMLTIDKDRIIdAGPkgnySRFMNHSCQP 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 55925233 253 NC---KFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCEC 296
Cdd:cd19211  86 NCetqKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRC 132
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 245-287 1.00e-05

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 45.41  E-value: 1.00e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 55925233 245 FINHDCRPNCKFVST---GRDTACVKVLRDIEPGEEISCYYGDGFF 287
Cdd:cd10522  76 FINHSDQPNLELIVRtlkGEQHIGFVAIRDIKPGEELFISYGPKYW 121
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 243-281 1.12e-05

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 47.29  E-value: 1.12e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 55925233 243 AAFINHDCRPNCkFVSTGRDTACVKVLRDIEPGEEIS-CY 281
Cdd:cd10536 151 LSLLNHSCDPNT-IRSFYGNTIVVRATRPIKKGEEITiCY 189
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 243-303 4.85e-05

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 43.82  E-value: 4.85e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55925233 243 AAFINHDCRPNC---KFVSTGRDTACVKVLRDIEPGEEISCYYG-DGFFGENNEFCECYTCERRG 303
Cdd:cd19174  73 ARFVNHSCDPNCemqKWSVNGVYRIGLFALKDIPAGEELTYDYNfHSFNVEKQQPCKCGSPNCRG 137
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 236-299 6.08e-05

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 43.74  E-value: 6.08e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55925233 236 AQLWLGPAAFINHDCRPNC--KFVST-GRDTACVKVLRDIEPGEEIScyYGDGFFGENNE----FCECYTC 299
Cdd:cd10518  81 ATKKGNIARFINHSCDPNCyaKIITVdGEKHIVIFAKRDIAPGEELT--YDYKFPIEDEEkipcLCGAPNC 149
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 243-284 4.58e-04

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 42.41  E-value: 4.58e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 55925233 243 AAFINHDCRPNCKFVSTGRDtACVKVLRDIEPGEEISCYYGD 284
Cdd:cd19167 138 AALLNHSCCPNCIVTFNGPN-IEVRAVQEIEPGEEVFHSYID 178
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 241-283 8.32e-04

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 41.59  E-value: 8.32e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 55925233 241 GPAAFINHDCRPN---CKFVSTGRDTACVKV----LRDIEPGEEISCYYG 283
Cdd:cd10538 168 NVSRFINHSCDPNlfpFNVVIDHDDLRYPRIalfaTRDILPGEELTFDYG 217
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 245-303 1.57e-03

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 41.13  E-value: 1.57e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55925233 245 FINHDCRPNCKFVSTGRDT----ACVKVLRDIEPGEEISCYYGDGFFGENNEFCECYTCERRG 303
Cdd:cd10544 172 FLNHSCEPNLFMVPVRVDSmvpkLALFAARDIVAGEELSFDYSGEFSNSVESVTLARQDESKS 234
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 245-296 1.86e-03

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 39.49  E-value: 1.86e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 55925233 245 FINHDCRPNC---KFVSTGRdtacVKV----LRDIEPGEEISCYYGDGFFGENNEFCEC 296
Cdd:cd19172  78 FINHSCEPNCetqKWTVNGE----LRVgffaKRDIPAGEELTFDYQFERYGKEAQKCYC 132
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 241-279 2.16e-03

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 39.69  E-value: 2.16e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 55925233 241 GPAAFINHDCRPNCKFVSTGRDTACV-----KVLRDIEPGEEIS 279
Cdd:cd19183  76 SVARFIRRSCRPNAELVTVASDSGSVlkfvlYASRDISPGEEIT 119
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 243-284 3.34e-03

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 39.66  E-value: 3.34e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 55925233 243 AAFINHDCRPNCKFVSTGRDTaCVKVLRDIEPGEEISCYYGD 284
Cdd:cd19203 143 ASLLNHSCDPNCVIVFNGPHL-LLRAIREIEVGEELTISYID 183
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 241-296 3.78e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 38.56  E-value: 3.78e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55925233 241 GPAAFINHDCRPNC--KFVSTGRDtacVKVL----RDIEPGEEISCYYGDGFFGENNEF-CEC 296
Cdd:cd19171  85 GPARYINHSCNPNCvaEVVTFDKE---KKIIiisnRRIAKGEELTYDYKFDFEDDQHKIpCLC 144
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 182-296 4.07e-03

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 38.37  E-value: 4.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 182 QNGAKIVATKDWKRNDKIEHLVGciaELSPSEE-RMLLRHG-ENDFSVMYS-TRKNCAQLWLGP----AAFINHDCRPNC 254
Cdd:cd19210  11 GRGWGLRCKTDIKKGEFVNEYVG---ELIDEEEcRARIRYAqEHDITNFYMlTLDKDRIIDAGPkgnyARFMNHCCQPNC 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 55925233 255 ---KFVSTGRDTACVKVLRDIEPGEEISCYYGDGFFGENNEFCEC 296
Cdd:cd19210  88 etqKWTVNGDTRVGLFALCDIKAGTELTFNYNLECLGNGKTVCKC 132
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 223-284 5.75e-03

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 37.61  E-value: 5.75e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55925233 223 NDFSVMYSTRKNCAqlwlgpAAFINHDCRPNC--KFVSTGRD-TACVKVLRDIEPGEEISCYYGD 284
Cdd:cd10519  59 NDQFVVDATRKGNK------IRFANHSSNPNCyaKVMMVNGDhRIGIFAKRDIEAGEELFFDYGY 117
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 241-285 7.23e-03

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 39.22  E-value: 7.23e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 55925233 241 GPAAFINHDCRPNCKFVSTGRDTA-------CVKVLRDIEPGEEISCYYGDG 285
Cdd:cd19473 192 GPTRFINHSCDPNLRIFARVGDHAdkhihdlAFFAIKDIPRGTELTFDYVDG 243
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 180-301 8.49e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 37.75  E-value: 8.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55925233 180 SEQNGAKIVATKDWKRNDKIEHLVGCIAELSPSEERMLLRHGENDFSVMYSTRKNC---AQLWLGPAAFINHDCRPNC-- 254
Cdd:cd19209  23 SRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHvidATLTGGPARYINHSCAPNCva 102

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 55925233 255 KFVSTGRDTACVKV-LRDIEPGEEISCYYGDGFFGENNEF-CEC--YTCER 301
Cdd:cd19209 103 EVVTFDKEDKIIIIsSRRIPKGEELTYDYQFDFEDDQHKIpCHCgaWNCRK 153
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 246-301 8.72e-03

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 38.55  E-value: 8.72e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55925233 246 INHDCRPNCKFVSTGRDTAcVKVLRDIEPGEEISCYYGDgfFGENNE-----------F-CECYTCER 301
Cdd:cd10526 146 VNHDCWPNCTVIFNNGRIE-LRALGKISEGDELTVSYID--FLNTSEdrkeqlkkqyyFdCTCEHCTK 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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