NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|558472801|ref|NP_001273748|]
View 

LETM1 domain-containing protein LETM2, mitochondrial isoform 4 [Homo sapiens]

Protein Classification

LETM1 domain-containing protein( domain architecture ID 18340129)

LETM1 domain-containing protein similar to mitochondrial proton/calcium exchanger protein (LETM1) which is a mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 174-390 7.32e-94

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


:

Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 283.99  E-value: 7.32e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801  174 DFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARrnrAKMGDAST 253
Cdd:pfam07766  15 DLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEESLS---DETTELKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801  254 QLSSYVKQVQ-TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAK 332
Cdd:pfam07766  92 EFKEFFKKVRsGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDRAIAR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 558472801  333 EGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFY 390
Cdd:pfam07766 172 EGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
LETM2_N pfam19324
LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region ...
 1-111 2.89e-79

LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region of the LETM1-domain- containing protein LETM2, a mitochondrial protein that is expressed preferentially in spermatocytes and spermatozoa during developmental stages from spermatocyte to spermatozoon. LETM2 might contribute to the reorganization of the inner and cristae membranes during spermatogenesis. Despite its name, it does not contain an EF-hand domain as LETM1, but it contains a putative leucine zipper coiled coil domain.


:

Pssm-ID: 466042  Cd Length: 111  Bit Score: 242.39  E-value: 2.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801    1 MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTS 80
Cdd:pfam19324   1 MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSLAFLHLPDSHLNKTYMKNYGSKKYSYPSQSGNKVLHLRTRLIQKLHTS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 558472801   81 TCWLQEVPGKPQLEQATKHPQVTSPQATKET 111
Cdd:pfam19324  81 TCWLQEVPGKPQLEQTTEKPQVTSPQPTKET 111
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 174-390 7.32e-94

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 283.99  E-value: 7.32e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801  174 DFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARrnrAKMGDAST 253
Cdd:pfam07766  15 DLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEESLS---DETTELKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801  254 QLSSYVKQVQ-TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAK 332
Cdd:pfam07766  92 EFKEFFKKVRsGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDRAIAR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 558472801  333 EGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFY 390
Cdd:pfam07766 172 EGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
LETM2_N pfam19324
LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region ...
 1-111 2.89e-79

LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region of the LETM1-domain- containing protein LETM2, a mitochondrial protein that is expressed preferentially in spermatocytes and spermatozoa during developmental stages from spermatocyte to spermatozoon. LETM2 might contribute to the reorganization of the inner and cristae membranes during spermatogenesis. Despite its name, it does not contain an EF-hand domain as LETM1, but it contains a putative leucine zipper coiled coil domain.


Pssm-ID: 466042  Cd Length: 111  Bit Score: 242.39  E-value: 2.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801    1 MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTS 80
Cdd:pfam19324   1 MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSLAFLHLPDSHLNKTYMKNYGSKKYSYPSQSGNKVLHLRTRLIQKLHTS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 558472801   81 TCWLQEVPGKPQLEQATKHPQVTSPQATKET 111
Cdd:pfam19324  81 TCWLQEVPGKPQLEQTTEKPQVTSPQPTKET 111
 
Name Accession Description Interval E-value
LETM1_RBD pfam07766
LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a ...
 174-390 7.32e-94

LETM1-like, RBD; Members of this entry are inner mitochondrial membrane proteins which play a role in potassium and hydrogen ion exchange. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans. This entry represents the ribosome-binding domain (RBD) of LETM1/MDM38 proteins.


Pssm-ID: 462258 [Multi-domain]  Cd Length: 229  Bit Score: 283.99  E-value: 7.32e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801  174 DFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARrnrAKMGDAST 253
Cdd:pfam07766  15 DLFRLVPFSVFIIVPFAELLLPVLLKLFPNLLPSTFWSKKQKEEKLKKRLKARLEVAKFLQETVEESLS---DETTELKE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801  254 QLSSYVKQVQ-TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAK 332
Cdd:pfam07766  92 EFKEFFKKVRsGGEPPSNEEILKVAKLFKDDLTLDNLSRPQLVALCKYMNLTPFGTDNLLRYRLRHKLLEIKRDDRAIAR 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 558472801  333 EGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFY 390
Cdd:pfam07766 172 EGVDSLSLEELQSACYSRGIRPLGLSEERLREWLQQWLDLSLNLKVPSSLLLLSRAVL 229
LETM2_N pfam19324
LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region ...
 1-111 2.89e-79

LETM1 domain-containing protein LETM2 N-terminus; This family represents the N-terminal region of the LETM1-domain- containing protein LETM2, a mitochondrial protein that is expressed preferentially in spermatocytes and spermatozoa during developmental stages from spermatocyte to spermatozoon. LETM2 might contribute to the reorganization of the inner and cristae membranes during spermatogenesis. Despite its name, it does not contain an EF-hand domain as LETM1, but it contains a putative leucine zipper coiled coil domain.


Pssm-ID: 466042  Cd Length: 111  Bit Score: 242.39  E-value: 2.89e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472801    1 MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTS 80
Cdd:pfam19324   1 MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSLAFLHLPDSHLNKTYMKNYGSKKYSYPSQSGNKVLHLRTRLIQKLHTS 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 558472801   81 TCWLQEVPGKPQLEQATKHPQVTSPQATKET 111
Cdd:pfam19324  81 TCWLQEVPGKPQLEQTTEKPQVTSPQPTKET 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH