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Conserved domains on  [gi|55824666|gb|AAH35356|]
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Allantoicase [Homo sapiens]

Protein Classification

allantoicase( domain architecture ID 1904142)

allantoicase catalyzes the conversion from allantoate and H(2)O to (S)-ureidoglycolate and urea

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
allantoicase super family cl44352
allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called ...
 1-137 4.65e-61

allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called allantoate amidinohydrolase. This enzyme hydrolyzes allantoate to (S)-ureidoglycolate and urea; it can also degrade (R)-ureidoglycolate to glyoxylate and urea. Allantoinase (EC 3.5.2.5) hydrolyzes (S)-allantoin (a xanthine metabolite, via urate) to allantoate. Allantoate can then be degraded either by this enzyme, allantoicase, or by allantoate deiminase (EC 3.5.3.9). Members of the seed alignment for this model were taken from BRENDA. Proteins in this family contain two copies of the allantoicase repeat (pfam03561). A different but similarly named enzyme, allantoate amidohydrolase (EC 3.5.3.9), simultaneously breaks down the urea to ammonia and carbon dioxide. [Purines, pyrimidines, nucleosides, and nucleotides, Other, Energy metabolism, Other]


The actual alignment was detected with superfamily member TIGR02961:

Pssm-ID: 274363 [Multi-domain]  Cd Length: 322  Bit Score: 191.38  E-value: 4.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666     1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQk 80
Cdd:TIGR02961 207 MGDGWETARRRD---------------PGNDWAIVRLGAPGEIERIEVDTAHFKGNYPDSCSLQAADLEGGEDEQLITQ- 270

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 55824666    81 wilpAHKWKPLLPVTKLSPNQSHLFDSlTLELQDVITHARLTIVPDGGVSRLRLRGF 137
Cdd:TIGR02961 271 ----SMFWVELLPRTKLGPDTEHVFES-SLAASGPVTHVRLNIIPDGGVSRLRLWGR 322
 
Name Accession Description Interval E-value
allantoicase TIGR02961
allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called ...
 1-137 4.65e-61

allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called allantoate amidinohydrolase. This enzyme hydrolyzes allantoate to (S)-ureidoglycolate and urea; it can also degrade (R)-ureidoglycolate to glyoxylate and urea. Allantoinase (EC 3.5.2.5) hydrolyzes (S)-allantoin (a xanthine metabolite, via urate) to allantoate. Allantoate can then be degraded either by this enzyme, allantoicase, or by allantoate deiminase (EC 3.5.3.9). Members of the seed alignment for this model were taken from BRENDA. Proteins in this family contain two copies of the allantoicase repeat (pfam03561). A different but similarly named enzyme, allantoate amidohydrolase (EC 3.5.3.9), simultaneously breaks down the urea to ammonia and carbon dioxide. [Purines, pyrimidines, nucleosides, and nucleotides, Other, Energy metabolism, Other]


Pssm-ID: 274363 [Multi-domain]  Cd Length: 322  Bit Score: 191.38  E-value: 4.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666     1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQk 80
Cdd:TIGR02961 207 MGDGWETARRRD---------------PGNDWAIVRLGAPGEIERIEVDTAHFKGNYPDSCSLQAADLEGGEDEQLITQ- 270

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 55824666    81 wilpAHKWKPLLPVTKLSPNQSHLFDSlTLELQDVITHARLTIVPDGGVSRLRLRGF 137
Cdd:TIGR02961 271 ----SMFWVELLPRTKLGPDTEHVFES-SLAASGPVTHVRLNIIPDGGVSRLRLWGR 322
Allantoicase pfam03561
Allantoicase repeat; This family is found in pairs in Allantoicases, forming the majority of ...
 1-139 4.40e-52

Allantoicase repeat; This family is found in pairs in Allantoicases, forming the majority of the protein. These proteins allow the use of purines as secondary nitrogen sources in nitrogen-limiting conditions through the reaction: allantoate + H(2)0 = (-)-ureidoglycolate + urea.


Pssm-ID: 460972 [Multi-domain]  Cd Length: 150  Bit Score: 162.64  E-value: 4.40e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666     1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEavirqk 80
Cdd:pfam03561  34 MGDGWETRRRRD---------------PGHDWAIIRLGAPGVIRGIEVDTAHFKGNYPPSVSVEAAYLPGDEDE------ 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 55824666    81 WILPAHKWKPLLPVTKLSPNQSHLFDSLTLElQDVITHARLTIVPDGGVSRLRLRGFPS 139
Cdd:pfam03561  93 PELDDAGWTELLPRTKLGPDQRHFFEVDSLT-DKRYTHVRLNIYPDGGVARLRVYGRVV 150
Alc COG4266
Allantoicase [Nucleotide transport and metabolism];
1-140 1.40e-45

Allantoicase [Nucleotide transport and metabolism];


Pssm-ID: 443407 [Multi-domain]  Cd Length: 331  Bit Score: 151.51  E-value: 1.40e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666   1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQk 80
Cdd:COG4266 213 MGDGWETRRRRD---------------PGNDWVIVRLAAPGVVERIEVDTAHFKGNAPDRASLQGADAPGGTDASLITQ- 276

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666  81 wilpAHKWKPLLPVTKLSPNQSHLFDslTLELQDVITHARLTIVPDGGVSRLRLRGFPSS 140
Cdd:COG4266 277 ----SMFWFELLPRTKLQPDTRHRFR--ELAAAGPVTHVRLNIFPDGGVSRLRLFGRLTE 330
PRK13797 PRK13797
allantoicase;
1-139 7.20e-31

allantoicase;


Pssm-ID: 106738 [Multi-domain]  Cd Length: 516  Bit Score: 116.22  E-value: 7.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666    1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGC----ILTTQEEEAv 76
Cdd:PRK13797 219 MGEGWETRRRRG---------------PGHDWAVVRLATQGTIVRAEVDTRHFRGNAPRAVALWAAdapdLLDPDDLAA- 282

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55824666   77 irqkwilpAHKWKPLLPVTKLSPNQSHLFDsltLELQDVITHARLTIVPDGGVSRLRLRGFPS 139
Cdd:PRK13797 283 --------ITEWRPLLPRTRVQPNTRHLFD---LEVPVQATHVRVDAIPDGGLARLRLTGAPT 334
 
Name Accession Description Interval E-value
allantoicase TIGR02961
allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called ...
 1-137 4.65e-61

allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called allantoate amidinohydrolase. This enzyme hydrolyzes allantoate to (S)-ureidoglycolate and urea; it can also degrade (R)-ureidoglycolate to glyoxylate and urea. Allantoinase (EC 3.5.2.5) hydrolyzes (S)-allantoin (a xanthine metabolite, via urate) to allantoate. Allantoate can then be degraded either by this enzyme, allantoicase, or by allantoate deiminase (EC 3.5.3.9). Members of the seed alignment for this model were taken from BRENDA. Proteins in this family contain two copies of the allantoicase repeat (pfam03561). A different but similarly named enzyme, allantoate amidohydrolase (EC 3.5.3.9), simultaneously breaks down the urea to ammonia and carbon dioxide. [Purines, pyrimidines, nucleosides, and nucleotides, Other, Energy metabolism, Other]


Pssm-ID: 274363 [Multi-domain]  Cd Length: 322  Bit Score: 191.38  E-value: 4.65e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666     1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQk 80
Cdd:TIGR02961 207 MGDGWETARRRD---------------PGNDWAIVRLGAPGEIERIEVDTAHFKGNYPDSCSLQAADLEGGEDEQLITQ- 270

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 55824666    81 wilpAHKWKPLLPVTKLSPNQSHLFDSlTLELQDVITHARLTIVPDGGVSRLRLRGF 137
Cdd:TIGR02961 271 ----SMFWVELLPRTKLGPDTEHVFES-SLAASGPVTHVRLNIIPDGGVSRLRLWGR 322
Allantoicase pfam03561
Allantoicase repeat; This family is found in pairs in Allantoicases, forming the majority of ...
 1-139 4.40e-52

Allantoicase repeat; This family is found in pairs in Allantoicases, forming the majority of the protein. These proteins allow the use of purines as secondary nitrogen sources in nitrogen-limiting conditions through the reaction: allantoate + H(2)0 = (-)-ureidoglycolate + urea.


Pssm-ID: 460972 [Multi-domain]  Cd Length: 150  Bit Score: 162.64  E-value: 4.40e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666     1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEavirqk 80
Cdd:pfam03561  34 MGDGWETRRRRD---------------PGHDWAIIRLGAPGVIRGIEVDTAHFKGNYPPSVSVEAAYLPGDEDE------ 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 55824666    81 WILPAHKWKPLLPVTKLSPNQSHLFDSLTLElQDVITHARLTIVPDGGVSRLRLRGFPS 139
Cdd:pfam03561  93 PELDDAGWTELLPRTKLGPDQRHFFEVDSLT-DKRYTHVRLNIYPDGGVARLRVYGRVV 150
Alc COG4266
Allantoicase [Nucleotide transport and metabolism];
1-140 1.40e-45

Allantoicase [Nucleotide transport and metabolism];


Pssm-ID: 443407 [Multi-domain]  Cd Length: 331  Bit Score: 151.51  E-value: 1.40e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666   1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQk 80
Cdd:COG4266 213 MGDGWETRRRRD---------------PGNDWVIVRLAAPGVVERIEVDTAHFKGNAPDRASLQGADAPGGTDASLITQ- 276

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666  81 wilpAHKWKPLLPVTKLSPNQSHLFDslTLELQDVITHARLTIVPDGGVSRLRLRGFPSS 140
Cdd:COG4266 277 ----SMFWFELLPRTKLQPDTRHRFR--ELAAAGPVTHVRLNIFPDGGVSRLRLFGRLTE 330
allantoicase TIGR02961
allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called ...
 3-138 1.94e-32

allantoicase; Members of this family are the enzyme allantoicase (EC 3.5.3.4), also called allantoate amidinohydrolase. This enzyme hydrolyzes allantoate to (S)-ureidoglycolate and urea; it can also degrade (R)-ureidoglycolate to glyoxylate and urea. Allantoinase (EC 3.5.2.5) hydrolyzes (S)-allantoin (a xanthine metabolite, via urate) to allantoate. Allantoate can then be degraded either by this enzyme, allantoicase, or by allantoate deiminase (EC 3.5.3.9). Members of the seed alignment for this model were taken from BRENDA. Proteins in this family contain two copies of the allantoicase repeat (pfam03561). A different but similarly named enzyme, allantoate amidohydrolase (EC 3.5.3.9), simultaneously breaks down the urea to ammonia and carbon dioxide. [Purines, pyrimidines, nucleosides, and nucleotides, Other, Energy metabolism, Other]


Pssm-ID: 274363 [Multi-domain]  Cd Length: 322  Bit Score: 117.42  E-value: 1.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666     3 DGWETARRldRPPilendengillvpGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILttQEEEAVIrqkwI 82
Cdd:TIGR02961  49 DGWETRRK--RGA-------------GHDWCIVRLGVPGVIHGVDIDTSFFTGNYPPAVSIEACLS--PEPSPEI----L 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 55824666    83 LPAHKWKPLLPVTKLSPNQSHLFDSLTlelQDVITHARLTIVPDGGVSRLRLRGFP 138
Cdd:TIGR02961 108 LDSTEWVELLPRTELGPSQHHYFEVSS---KQRFTHIRLNIYPDGGIARLRVYGIV 160
PRK13797 PRK13797
allantoicase;
1-139 7.20e-31

allantoicase;


Pssm-ID: 106738 [Multi-domain]  Cd Length: 516  Bit Score: 116.22  E-value: 7.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666    1 MADGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGC----ILTTQEEEAv 76
Cdd:PRK13797 219 MGEGWETRRRRG---------------PGHDWAVVRLATQGTIVRAEVDTRHFRGNAPRAVALWAAdapdLLDPDDLAA- 282

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55824666   77 irqkwilpAHKWKPLLPVTKLSPNQSHLFDsltLELQDVITHARLTIVPDGGVSRLRLRGFPS 139
Cdd:PRK13797 283 --------ITEWRPLLPRTRVQPNTRHLFD---LEVPVQATHVRVDAIPDGGLARLRLTGAPT 334
Alc COG4266
Allantoicase [Nucleotide transport and metabolism];
3-139 3.78e-30

Allantoicase [Nucleotide transport and metabolism];


Pssm-ID: 443407 [Multi-domain]  Cd Length: 331  Bit Score: 111.45  E-value: 3.78e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666   3 DGWETARRLDrppilendengillvPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVirqkwi 82
Cdd:COG4266  55 DGWETRRRRE---------------PGHDWAIVRLGAPGVIRGVDVDTAHFTGNYPPAASVEACSVEGYPDPEE------ 113

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 55824666  83 LPAHKWKPLLPVTKLSPNQSHLFDsltLELQDVITHARLTIVPDGGVSRLRLRGFPS 139
Cdd:COG4266 114 LADAEWTELLPRSPLGGDSHNLFE---VASERRWTHVRLNIYPDGGVARLRVYGEPV 167
PRK13797 PRK13797
allantoicase;
3-136 1.18e-25

allantoicase;


Pssm-ID: 106738 [Multi-domain]  Cd Length: 516  Bit Score: 101.59  E-value: 1.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55824666    3 DGWETARRLDrppilendengillVPGCEWAVFRLAHPGVITRIEIDTKYFEGNAPDSCKVDGCILTTQEEEAVIRQkwi 82
Cdd:PRK13797  57 DGWETRRRRD--------------LPGADWAIVRLGAPGIAHAVTVDTTHFTGNAPEAVEIHGATLAGYPSAEDVAD--- 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 55824666   83 lPAHKWKPLLPVTKLSPNQSHLFDsLTLELQDVITHARLTIVPDGGVSRLRLRG 136
Cdd:PRK13797 120 -DSVHWVELVPRTPIAADAVNVLP-VASSGRLRITHLRLTIHPDGGVARLRVHG 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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