NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|558221377|ref|XP_006135977|]
View 

annexin A7 isoform X3 [Pelodiscus sinensis]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 157-222 2.42e-31

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 114.49  E-value: 2.42e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  157 RDAEILRKAMKGFGTDEQAIINVVANRSNDQRQKIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 222
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 229-294 1.53e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 104.09  E-value: 1.53e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  229 YDAWSLRHAMKGAGTQERVLIEILCTRTNQEIQNIVRTYKTEFGRDIEQDIRADTSGHFERLLVSM 294
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 388-453 8.14e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 8.14e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  388 FFADRIYHSMKGAGTDDSTLVRIVVTRSEIDLVQIKQLFTQMYQKTLATMISSDTSGDYRNLLLAI 453
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 313-378 9.79e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.82  E-value: 9.79e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  313 DAQRLYQAgEGKLGTDESCFNMILATRSFPQLKATVEAYSQIANRDLLSSIGREFSGNVEDGLKTI 378
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
PHA03378 super family cl33729
EBNA-3B; Provisional
 12-168 1.92e-07

EBNA-3B; Provisional


The actual alignment was detected with superfamily member PHA03378:

Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.53  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  12 PAFPGYPPPGQESV-----YSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGfPGAAgyPAPGGYPGVPQPGGMPSYPGAP 86
Cdd:PHA03378 670 GHIPYQPSPTGANTmlpiqWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAA-TGRA--RPPAAAPGRARPPAAAPGRARP 746

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  87 TGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQ-----VPSPVPtQPTAMTQSTQGTIQAAPNfDAGRDAEI 161
Cdd:PHA03378 747 PAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQqrprgAPTPQP-PPQAGPTSMQLMPRAAPG-QQGPTKQI 824


                 ....*..
gi 558221377 162 LRKAMKG 168
Cdd:PHA03378 825 LRQLLTG 831
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 157-222 2.42e-31

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 114.49  E-value: 2.42e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  157 RDAEILRKAMKGFGTDEQAIINVVANRSNDQRQKIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 222
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 229-294 1.53e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 104.09  E-value: 1.53e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  229 YDAWSLRHAMKGAGTQERVLIEILCTRTNQEIQNIVRTYKTEFGRDIEQDIRADTSGHFERLLVSM 294
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 388-453 8.14e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 8.14e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  388 FFADRIYHSMKGAGTDDSTLVRIVVTRSEIDLVQIKQLFTQMYQKTLATMISSDTSGDYRNLLLAI 453
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
170-222 4.75e-24

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 94.40  E-value: 4.75e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 558221377   170 GTDEQAIINVVANRSNDQRQKIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 222
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
242-294 2.75e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 89.39  E-value: 2.75e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 558221377   242 GTQERVLIEILCTRTNQEIQNIVRTYKTEFGRDIEQDIRADTSGHFERLLVSM 294
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
401-453 4.82e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 83.23  E-value: 4.82e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 558221377   401 GTDDSTLVRIVVTRSEIDLVQIKQLFTQMYQKTLATMISSDTSGDYRNLLLAI 453
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 313-378 9.79e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.82  E-value: 9.79e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  313 DAQRLYQAgEGKLGTDESCFNMILATRSFPQLKATVEAYSQIANRDLLSSIGREFSGNVEDGLKTI 378
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
326-375 4.17e-12

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 60.88  E-value: 4.17e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 558221377   326 GTDESCFNMILATRSFPQLKATVEAYSQIANRDLLSSIGREFSGNVEDGL 375
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
PHA03378 PHA03378
EBNA-3B; Provisional
 12-168 1.92e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.53  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  12 PAFPGYPPPGQESV-----YSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGfPGAAgyPAPGGYPGVPQPGGMPSYPGAP 86
Cdd:PHA03378 670 GHIPYQPSPTGANTmlpiqWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAA-TGRA--RPPAAAPGRARPPAAAPGRARP 746

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  87 TGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQ-----VPSPVPtQPTAMTQSTQGTIQAAPNfDAGRDAEI 161
Cdd:PHA03378 747 PAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQqrprgAPTPQP-PPQAGPTSMQLMPRAAPG-QQGPTKQI 824


                 ....*..
gi 558221377 162 LRKAMKG 168
Cdd:PHA03378 825 LRQLLTG 831
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 12-90 2.72e-04

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 42.28  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   12 PAFPgYPPPGqesvysPAGQYPYPAVPGGFPPMGGSAYPAVP--PAGGFPGAAG-YPAPGGYPGVPQPGGMPSYP-GAPT 87
Cdd:pfam15822 160 PNMP-YPSPG------PYPAVPPPQSPGAAPPVPWGTVPPGPwgPPAPYPDPTGsYPMPGLYPTPNNPFQVPSGPsGAPP 232


                  ...
gi 558221377   88 GPG 90
Cdd:pfam15822 233 MPG 235
PRP smart00157
Major prion protein; The prion protein is a major component of scrapie-associated fibrils in ...
 38-115 9.91e-04

Major prion protein; The prion protein is a major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, Gerstmann-Straussler syndrome and bovine spongiform encephalopathy.


Pssm-ID: 197548 [Multi-domain]  Cd Length: 218  Bit Score: 40.62  E-value: 9.91e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558221377    38 PGGFPPMGGSAYPAvppaGGFPGAAGYPAPGGYPGVPQPGGmpsypGAPTGPGFGVAPNGsgfGGYPQPPSQSYGGGG 115
Cdd:smart00157   6 PGGGWNTGGSRYPG----QGSPGGNRYPPQGGGWGQPHGGG-----WGQPHGGGWGQPHG---GGWGQPHGGGWGQGG 71
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 21-150 2.45e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.18  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   21 GQESVYSPAGQYPYPAVPG-GFPPMGGSAypavppaggfPGAAGYPAPGGYPGVPQPGGmPSYPGAPTGPGFGVAPNGSG 99
Cdd:TIGR01628 376 MQLQPRMRQLPMGSPMGGAmGQPPYYGQG----------PQQQFNGQPLGWPRMSMMPT-PMGPGGPLRPNGLAPMNAVR 444

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 558221377  100 FGGYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQPTAMTQSTQGTIQAA 150
Cdd:TIGR01628 445 APSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQ 495
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 4-160 3.28e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 39.66  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   4 PGYPPSGYPAFPGYPPPGQESVYSPAGQYP--YPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPS 81
Cdd:COG5180  358 AEEAVPGKPLEQGAPRPGSSGGDGAPFQPPngAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAGGAGQGPK 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  82 YPGAP-------TGPGFGVAPNGSGFG--GYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQPTAMTQSTQGTIQAAPN 152
Cdd:COG5180  438 ADFVPgdaesvsGPAGLADQAGAAASTamADFVAPVTDATPVDVADVLGVRPDAILGGNVAPASGLDAETRIIEAEGAPA 517


                 ....*...
gi 558221377 153 FDAGRDAE 160
Cdd:COG5180  518 TEDFVAAE 525
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 157-222 2.42e-31

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 114.49  E-value: 2.42e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  157 RDAEILRKAMKGFGTDEQAIINVVANRSNDQRQKIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 222
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 229-294 1.53e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 104.09  E-value: 1.53e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  229 YDAWSLRHAMKGAGTQERVLIEILCTRTNQEIQNIVRTYKTEFGRDIEQDIRADTSGHFERLLVSM 294
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 388-453 8.14e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 96.77  E-value: 8.14e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  388 FFADRIYHSMKGAGTDDSTLVRIVVTRSEIDLVQIKQLFTQMYQKTLATMISSDTSGDYRNLLLAI 453
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
170-222 4.75e-24

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 94.40  E-value: 4.75e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 558221377   170 GTDEQAIINVVANRSNDQRQKIKAAFKTMYGKDLIKDLKSELSGNMEELILAL 222
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
242-294 2.75e-22

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 89.39  E-value: 2.75e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 558221377   242 GTQERVLIEILCTRTNQEIQNIVRTYKTEFGRDIEQDIRADTSGHFERLLVSM 294
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
401-453 4.82e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 83.23  E-value: 4.82e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 558221377   401 GTDDSTLVRIVVTRSEIDLVQIKQLFTQMYQKTLATMISSDTSGDYRNLLLAI 453
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 313-378 9.79e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.82  E-value: 9.79e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  313 DAQRLYQAgEGKLGTDESCFNMILATRSFPQLKATVEAYSQIANRDLLSSIGREFSGNVEDGLKTI 378
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
326-375 4.17e-12

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 60.88  E-value: 4.17e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 558221377   326 GTDESCFNMILATRSFPQLKATVEAYSQIANRDLLSSIGREFSGNVEDGL 375
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
PHA03378 PHA03378
EBNA-3B; Provisional
 12-168 1.92e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.53  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  12 PAFPGYPPPGQESV-----YSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGfPGAAgyPAPGGYPGVPQPGGMPSYPGAP 86
Cdd:PHA03378 670 GHIPYQPSPTGANTmlpiqWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAA-TGRA--RPPAAAPGRARPPAAAPGRARP 746

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  87 TGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQ-----VPSPVPtQPTAMTQSTQGTIQAAPNfDAGRDAEI 161
Cdd:PHA03378 747 PAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQqrprgAPTPQP-PPQAGPTSMQLMPRAAPG-QQGPTKQI 824


                 ....*..
gi 558221377 162 LRKAMKG 168
Cdd:PHA03378 825 LRQLLTG 831
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-138 4.85e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 4.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    4 PGYPPSGYPAFPGYPPPGQESVYSPAGQYPyPAVPGGFPPMGGSAYPAVPPAggfPGAAGYPAPGGYPGVPQPGGMPSYP 83
Cdd:PHA03247 2712 PHALVSATPLPPGPAAARQASPALPAAPAP-PAVPAGPATPGGPARPARPPT---TAGPPAPAPPAAPAAGPPRRLTRPA 2787

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 558221377   84 GAPTGPGFGVAPNGSGfggyPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQPTA 138
Cdd:PHA03247 2788 VASLSESRESLPSPWD----PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 12-156 8.85e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 8.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  12 PAFPGYPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAYPA-VPPAGGFPGAAGYPAPGGyPGVPQPGGMPSYPGAPTGPG 90
Cdd:PRK07764 647 VAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPApAAPAAPAGAAPAQPAPAP-AATPPAGQADDPAAQPPQAA 725

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377  91 FGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQPTAMTQSTQGTIQAAPNFDAG 156
Cdd:PRK07764 726 QGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAP 791
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-143 5.07e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    4 PGYPPSGYPAFPGY-----PPPGQESVYSPAG--QYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQP 76
Cdd:PHA03247 2722 PPGPAAARQASPALpaapaPPAVPAGPATPGGpaRPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSP 2801

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377   77 GGMPSYPGAPTGPGFGVAPNGSGFGGYPQPPS------QSYGGGGPAQIPMG---YPGGQVPSPVPTQPTAMTQST 143
Cdd:PHA03247 2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSaqptapPPPPGPPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAA 2877
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 8-88 8.30e-06

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 47.90  E-value: 8.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   8 PSGYPA-FPGYPPPGQEsvyspaGQYPYPAVPGGFPPMGGSAYPavPPAGGFPGAAGYPAPG-GYPGVPQPGGM------ 79
Cdd:PRK13729 130 ATGEPVpQMPASPPGPE------GEPQPGNTPVSFPPQGSVAVP--PPTAFYPGNGVTPPPQvTYQSVPVPNRIqrktft 201

                         90
                 ....*....|....*.
gi 558221377  80 -------PSYPGAPTG 88
Cdd:PRK13729 202 ynegkkgPSLPYIPSG 217
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 36-160 1.28e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.67  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  36 AVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPSYPGAPTGP----GFGVAPNGSGFGGYPQPPSQSY 111
Cdd:PRK07764 586 AVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEAsaapAPGVAAPEHHPKHVAVPDASDG 665

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 558221377 112 GGGGPAQIPMGYPGGQVPSPVPTQPTAmtQSTQGTIQAAPNFDAGRDAE 160
Cdd:PRK07764 666 GDGWPAKAGGAAPAAPPPAPAPAAPAA--PAGAAPAQPAPAPAATPPAG 712
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 22-156 1.62e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  22 QESVYSPAGQYPYPAvPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPggyPGVPQPGGMPSYPGAPTGPGFGVAPNGSGFG 101
Cdd:PRK07764 381 LERRLGVAGGAGAPA-AAAPSAAAAAPAAAPAPAAAAPAAAAAPAP---AAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP 456

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 558221377 102 -GYPQPPSQSYGGGGPAQIPMGYPGGQvPSPVPTQPTAMTQSTQGTIQAAPNFDAG 156
Cdd:PRK07764 457 pPAAAPSAQPAPAPAAAPEPTAAPAPA-PPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 4-131 5.25e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 5.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   4 PGYPPSGYPAFPGYPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGfPGAAGYPAPGGYPGVPQPGGMPSYP 83
Cdd:PRK07764 616 AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW-PAKAGGAAPAAPPPAPAPAAPAAPA 694

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 558221377  84 GAPTGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQVPSP 131
Cdd:PRK07764 695 GAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP 742
PHA03378 PHA03378
EBNA-3B; Provisional
 1-130 8.03e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.06  E-value: 8.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   1 MSYPGYPPSGYPAFPGYPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGfPGAAgyPAPGGYPGVPQPGGMP 80
Cdd:PHA03378 704 MRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAA-PGRA--RPPAAAPGAPTPQPPP 780

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 558221377  81 SYPGAPTGpgfgvAPNGsgfGGYPQPPSQsyggGGPAQI---PMGYPGGQVPS 130
Cdd:PHA03378 781 QAPPAPQQ-----RPRG---APTPQPPPQ----AGPTSMqlmPRAAPGQQGPT 821
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 7-156 9.69e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 9.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   7 PPSGYPAFPGYPPPGQESvysPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPSYPGAP 86
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSG---PPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558221377  87 TG-PGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQ-VPSPVPTQPTAMTQSTQGTIQAAPNFDAG 156
Cdd:PRK07764 667 DGwPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATpPAGQADDPAAQPPQAAQGASAPSPAADDP 738
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 23-160 1.30e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  23 ESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPSYPG--APTGPGFGVAPNGSGF 100
Cdd:PRK07764 585 EAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGvaAPEHHPKHVAVPDASD 664

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 558221377 101 GGYPQPPS---QSYGGGGPAQIPMGYPGGQVPSPVPTQPTAMTQSTQGTIQAAPNFDAGRDAE 160
Cdd:PRK07764 665 GGDGWPAKaggAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQG 727
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-151 1.31e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    4 PGYPPSGYPAFPGYPPPGQESVYSPAGQYPYPAVPggFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPSYP 83
Cdd:PHA03247 2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATP--LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTT 2763

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558221377   84 GAPTGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAqIPMGYPGGQVPSPVPTQPTAMTQSTQGTIQAAP 151
Cdd:PHA03247 2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRES-LPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-151 1.67e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    4 PGYPPSGYPAFPGYPPP---GQESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPggypgvpQPGGMP 80
Cdd:PHA03247 2867 PSRSPAAKPAAPARPPVrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPP-------PPPPRP 2939

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 558221377   81 SYPGAPTGpgfGVAPNGSGFGGYPQPpsqSYGGGGPAQIPMgyPGGQVPSPVPTQPTAMTQSTQGTIQAAP 151
Cdd:PHA03247 2940 QPPLAPTT---DPAGAGEPSGAVPQP---WLGALVPGRVAV--PRFRVPQPAPSREAPASSTPPLTGHSLS 3002
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 12-90 2.72e-04

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 42.28  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   12 PAFPgYPPPGqesvysPAGQYPYPAVPGGFPPMGGSAYPAVP--PAGGFPGAAG-YPAPGGYPGVPQPGGMPSYP-GAPT 87
Cdd:pfam15822 160 PNMP-YPSPG------PYPAVPPPQSPGAAPPVPWGTVPPGPwgPPAPYPDPTGsYPMPGLYPTPNNPFQVPSGPsGAPP 232


                  ...
gi 558221377   88 GPG 90
Cdd:pfam15822 233 MPG 235
MISS pfam15822
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ...
 2-136 2.82e-04

MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.


Pssm-ID: 318115 [Multi-domain]  Cd Length: 238  Bit Score: 42.28  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    2 SYPGYPPSGYPAFPGYPPPGQESVySPAGQYPYPA---VPGGFPPMGgsAYPAVPPAGGFPGAA--------GYPAPGG- 69
Cdd:pfam15822  21 PKPGQPPQGWPGSNPWNNPSAPPA-VPSGLPPSTApstVPFGPAPTG--MYPSIPLTGPSPGPPapfppsgpSCPPPGGp 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   70 --YPGVPQPGGMPSYP-------------GAPTGPG----------FGVAPNGSGFGGYPQPPSQSYGGGGP--AQIPMG 122
Cdd:pfam15822  98 ypAPTVPGPGPIGPYPtpnmpfpelprpyGAPTDPAaaapsgpwgsMSSGPWAPGMGGQYPAPNMPYPSPGPypAVPPPQ 177

                         170
                  ....*....|....
gi 558221377  123 YPGGQVPSPVPTQP 136
Cdd:pfam15822 178 SPGAAPPVPWGTVP 191
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 5-107 4.13e-04

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 41.18  E-value: 4.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    5 GYPPSGYPAFPGYPPPGQESVYSPAGQYPYPAVPGG---FPPMGGSAYPAVPPAGGFPGaagyPAPGGYPGVPQPGGM-- 79
Cdd:pfam15240  37 GQSQQGGQGPQGPPPGGFPPQPPASDDPPGPPPPGGpqqPPPQGGKQKPQGPPPQGGPR----PPPGKPQGPPPQGGNqq 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 558221377   80 --PSYPGAPTGP---GFGVAPNGSGFGGYPQPP 107
Cdd:pfam15240 113 qgPPPPGKPQGPppqGGGPPPQGGNQQGPPPPP 145
dnaA PRK14086
chromosomal replication initiator protein DnaA;
2-160 5.21e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.51  E-value: 5.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   2 SYPGYP-PSGYPAFPGYPPPGQESVYSPAG-QYPYPAVPGGFPPMGGSAYPAVPPAGgFPGAAGYPAPGGYPGVPQPGGM 79
Cdd:PRK14086 117 PYEGYGgPRADDRPPGLPRQDQLPTARPAYpAYQQRPEPGAWPRAADDYGWQQQRLG-FPPRAPYASPASYAPEQERDRE 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  80 PSYPGAPTgpgfgvapNGSGFGGYPQP-PSQSYGGGGPAQIPMGYPG-GQVPSPVPTQPTAMTQSTQGTIQAAPNFDAGR 157
Cdd:PRK14086 196 PYDAGRPE--------YDQRRRDYDHPrPDWDRPRRDRTDRPEPPPGaGHVHRGGPGPPERDDAPVVPIRPSAPGPLAAQ 267


                 ...
gi 558221377 158 DAE 160
Cdd:PRK14086 268 PAP 270
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 8-136 6.34e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 6.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    8 PSGYPAFPGYPPPgqESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGgyPGVPQPGGMPSYPGAPT 87
Cdd:PRK10263  377 PEGYPQQSQYAQP--AVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYA--PAPEQPVAGNAWQAEEQ 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 558221377   88 GPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMgyPGGQVPSPV-----PTQP 136
Cdd:PRK10263  453 QSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQ--QPVVEPEPVveetkPARP 504
PRP smart00157
Major prion protein; The prion protein is a major component of scrapie-associated fibrils in ...
 38-115 9.91e-04

Major prion protein; The prion protein is a major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, Gerstmann-Straussler syndrome and bovine spongiform encephalopathy.


Pssm-ID: 197548 [Multi-domain]  Cd Length: 218  Bit Score: 40.62  E-value: 9.91e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558221377    38 PGGFPPMGGSAYPAvppaGGFPGAAGYPAPGGYPGVPQPGGmpsypGAPTGPGFGVAPNGsgfGGYPQPPSQSYGGGG 115
Cdd:smart00157   6 PGGGWNTGGSRYPG----QGSPGGNRYPPQGGGWGQPHGGG-----WGQPHGGGWGQPHG---GGWGQPHGGGWGQGG 71
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 39-146 1.16e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.20  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  39 GGFPPMGGSAYPAvpPAGGfpGAAGYPAPG--GYPGVPQPGGMPSYPGAPTGPGFGVAPNGSgfggYP---QPPSQSYGG 113
Cdd:PRK14959 376 GGASAPSGSAAEG--PASG--GAATIPTPGtqGPQGTAPAAGMTPSSAAPATPAPSAAPSPR----VPwddAPPAPPRSG 447

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 558221377 114 GGPaqipmgYPGGQVP--SPVPTQPtAMTQSTQGT 146
Cdd:PRK14959 448 IPP------RPAPRMPeaSPVPGAP-DSVASASDA 475
PHA03247 PHA03247
large tegument protein UL36; Provisional
 4-156 1.37e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    4 PGYPPSGYPAfPGYPPPgqesvysPAGQYPYPAVPGGFPP----MGGSAYPAVPPAGGFPGAAGYPAPGGyPGVPQPGGM 79
Cdd:PHA03247 2816 AALPPAASPA-GPLPPP-------TSAQPTAPPPPPGPPPpslpLGGSVAPGGDVRRRPPSRSPAAKPAA-PARPPVRRL 2886

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558221377   80 PSYPGAPTGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQVP--SPVPTQPTAMTQSTQGTIQAAPNFDAG 156
Cdd:PHA03247 2887 ARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPprPQPPLAPTTDPAGAGEPSGAVPQPWLG 2965
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2-139 1.73e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   2 SYPGYPPSGYPAFPGYPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYP---GVPQPGG 78
Cdd:PRK07764 640 SAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPpagQADDPAA 719

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 558221377  79 MPSYPGAPTGPGFGVA-------------PNGSGFGGYPQPPSQSYGGGGPAQIPmgypggQVPSPVPTQPTAM 139
Cdd:PRK07764 720 QPPQAAQGASAPSPAAddpvplppepddpPDPAGAPAQPPPPPAPAPAAAPAAAP------PPSPPSEEEEMAE 787
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 21-150 2.45e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.18  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   21 GQESVYSPAGQYPYPAVPG-GFPPMGGSAypavppaggfPGAAGYPAPGGYPGVPQPGGmPSYPGAPTGPGFGVAPNGSG 99
Cdd:TIGR01628 376 MQLQPRMRQLPMGSPMGGAmGQPPYYGQG----------PQQQFNGQPLGWPRMSMMPT-PMGPGGPLRPNGLAPMNAVR 444

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 558221377  100 FGGYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQPTAMTQSTQGTIQAA 150
Cdd:TIGR01628 445 APSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQ 495
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 5-172 2.84e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 40.05  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   5 GYPPSGyPAFPG--------YPPPGQ---ESVYSPAGQYPYPAVPGGFPPMGGSA-------YPAVPPAGGFP--GAAGY 64
Cdd:PRK14959 378 ASAPSG-SAAEGpasggaatIPTPGTqgpQGTAPAAGMTPSSAAPATPAPSAAPSprvpwddAPPAPPRSGIPprPAPRM 456

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  65 PAPGGYPGVP----QPGGMPSYPGAPTGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVptqptaMT 140
Cdd:PRK14959 457 PEASPVPGAPdsvaSASDAPPTLGDPSDTAEHTPSGPRTWDGFLEFCQGRNGQGGRLATVLRQATPEHADGR------LR 530

                        170       180       190
                 ....*....|....*....|....*....|..
gi 558221377 141 QSTQGTIQAAPNFDAGRDAEILRKAMKGFGTD 172
Cdd:PRK14959 531 LATMSSVQYERLTDAATETTLAGLVRDYFGDA 562
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 8-138 3.13e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   8 PSGYPAFPGYPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPSYPGAPT 87
Cdd:PRK07764 390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 558221377  88 gpgfgvapngsgfggyPQPPSQSygGGGPAQIPMGYPGGQVPSPVPTQPTA 138
Cdd:PRK07764 470 ----------------PAAAPEP--TAAPAPAPPAAPAPAAAPAAPAAPAA 502
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 35-182 3.16e-03

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 39.99  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   35 PAVPGGFPPMGGSAYPAVPPAGGFP---------GAAGYPAP-----GGYPGVPQPGGMPSYPGAPtGPGFGVAPNGSGF 100
Cdd:pfam09606 101 PMGPGPGGPMGQQMGGPGTASNLLAslgrpqmpmGGAGFPSQmsrvgRMQPGGQAGGMMQPSSGQP-GSGTPNQMGPNGG 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  101 GGYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQPTA-MTQSTQGTIQAAPNFDAGRDAEILRKAMKGFGTDEQAIINV 179
Cdd:pfam09606 180 PGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPADAGAqMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQSQLGM 259


                  ...
gi 558221377  180 VAN 182
Cdd:pfam09606 260 GIN 262
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 4-160 3.28e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 39.66  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   4 PGYPPSGYPAFPGYPPPGQESVYSPAGQYP--YPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPS 81
Cdd:COG5180  358 AEEAVPGKPLEQGAPRPGSSGGDGAPFQPPngAPQPGLGRRGAPGPPMGAGDLVQAALDGGGRETASLGGAAGGAGQGPK 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  82 YPGAP-------TGPGFGVAPNGSGFG--GYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQPTAMTQSTQGTIQAAPN 152
Cdd:COG5180  438 ADFVPgdaesvsGPAGLADQAGAAASTamADFVAPVTDATPVDVADVLGVRPDAILGGNVAPASGLDAETRIIEAEGAPA 517


                 ....*...
gi 558221377 153 FDAGRDAE 160
Cdd:COG5180  518 TEDFVAAE 525
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 4-136 3.30e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.97  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   4 PGYPPSGYPAFPGYPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPSYP 83
Cdd:PRK07764 601 PAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAA 680

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 558221377  84 GAPTGPGFGVAPNGSGFGGYPQPPSQSYGGGGPAQIPMGYPGGQVPSPVPTQP 136
Cdd:PRK07764 681 PPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP 733
Drf_FH1 pfam06346
Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs) ...
 9-136 3.85e-03

Formin Homology Region 1; This region is found in some of the Diaphanous related formins (Drfs). It consists of low complexity repeats of around 12 residues.


Pssm-ID: 461881 [Multi-domain]  Cd Length: 157  Bit Score: 37.93  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    9 SGYPAFPGYPPPGQESVYSPAGQYPYPAVPGGF-----PPMGGSAYpaVPPAGGFPGAAGYPAP---GGYPGVPQPGGMP 80
Cdd:pfam06346  11 STIPLPPGACIPTPPPLPGGGGPPPPPPLPGSAaipppPPLPGGTS--IPPPPPLPGAASIPPPpplPGSTGIPPPPPLP 88

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 558221377   81 SYPGAPTGPgfgvAPNGSGFGGYPQPPSQSYGGGGPAQIPM-GYPGGQVPSPVPTQP 136
Cdd:pfam06346  89 GGAGIPPPP----PPLPGGAGVPPPPPPLPGGPGIPPPPPFpGGPGIPPPPPGMGMP 141
dnaA PRK14086
chromosomal replication initiator protein DnaA;
36-157 4.05e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 39.42  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  36 AVPGGFPPMGGSAYPAvpPAGGFPGAAGYPAPGGYPGVPQPGGMPSYPGAPTG-PGFGVAPNGSGFGGYPQPPSQSyggg 114
Cdd:PRK14086  92 AGEPAPPPPHARRTSE--PELPRPGRRPYEGYGGPRADDRPPGLPRQDQLPTArPAYPAYQQRPEPGAWPRAADDY---- 165

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 558221377 115 GPAQIPMGYPggqvPSPVPTQPtamTQSTQGTIQAAPNFDAGR 157
Cdd:PRK14086 166 GWQQQRLGFP----PRAPYASP---ASYAPEQERDREPYDAGR 201
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
35-160 4.50e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.45  E-value: 4.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377  35 PAVPGGFPPmGGSAYPAVPPAGGFPGAAGYPAPG--GYPGVPQPGGMPS-----YPGAPTGPGFGVAPNGSgfggyPQPP 107
Cdd:PRK07003 360 PAVTGGGAP-GGGVPARVAGAVPAPGARAAAAVGasAVPAVTAVTGAAGaalapKAAAAAAATRAEAPPAA-----PAPP 433

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 558221377 108 SQSYGGGGPAQIPMGYPGGQvPSPVPTQPTAMTQSTQGTIQAAPNFDAGRDAE 160
Cdd:PRK07003 434 ATADRGDDAADGDAPVPAKA-NARASADSRCDERDAQPPADSGSASAPASDAP 485
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2-136 6.10e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.37  E-value: 6.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377    2 SYPGYPPSGYPafPGYPPPGQESVYSP-------AGQYPYPAVPGGFPPMGGSAYPAVPPAGGF-----PGAAGYPAPGG 69
Cdd:pfam03154 202 SAPSVPPQGSP--ATSQPPNQTQSTAAphtliqqTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPqplpqPSLHGQMPPMP 279

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 558221377   70 YPGVPQPGGMPsYPGAPTgpGFGVAPNGSGFGGypqPPSQSYGGGGPAQIPMGYPGGQvPSPVPTQP 136
Cdd:pfam03154 280 HSLQTGPSHMQ-HPVPPQ--PFPLTPQSSQSQV---PPGPSPAAPGQSQQRIHTPPSQ-SQLQSQQP 339
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 7-149 8.08e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 38.54  E-value: 8.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   7 PPSGYPAFPG------YPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAyPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMP 80
Cdd:PRK14951 366 PAAAAEAAAPaekktpARPEAAAPAAAPVAQAAAAPAPAAAPAAAASA-PAAPPAAAPPAPVAAPAAAAPAAAPAAAPAA 444

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 558221377  81 ----SYPGAPTGPGFGVAPNGSGfggyPQPPSQSyggggPAQIPMGypggqVPSPVPTQPTAMTQSTQGTIQA 149
Cdd:PRK14951 445 valaPAPPAQAAPETVAIPVRVA----PEPAVAS-----AAPAPAA-----APAAARLTPTEEGDVWHATVQQ 503
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 4-151 9.11e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 38.43  E-value: 9.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558221377   4 PGYPPSGYPAFPGYPPPGQESVYSPAGQYPYPAVPGGFPPMGGSAYPAVPPAGGFPGAAGYPAPGGYPGVPQPGGMPSyP 83
Cdd:PRK07764 600 PPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA-P 678

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558221377  84 GAPTGPGFGVAPNGsgfggyPQPPSQSYGGGGPAQIPmgyPGGQVPSPVPTQPTAMTQSTQGTIQAAP 151
Cdd:PRK07764 679 AAPPPAPAPAAPAA------PAGAAPAQPAPAPAATP---PAGQADDPAAQPPQAAQGASAPSPAADD 737
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH