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Conserved domains on  [gi|55749726|ref|NP_065833|]
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kelch-like protein 42 [Homo sapiens]

Protein Classification

kelch-like protein 42( domain architecture ID 13034538)

kelch-like protein 42 (KLHL42) is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 128-237 2.48e-52

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


:

Pssm-ID: 350553  Cd Length: 103  Bit Score: 172.65  E-value: 2.48e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 128 NNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSppqapgdvSLKQRLREARMTGTPVLVALGDFLGGPL 207
Cdd:cd18478   4 PNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPS--------SLKQQLRERRLRGTPALVALGDFLGTPL 75

                        90       100       110
                ....*....|....*....|....*....|
gi 55749726 208 AphPYQGEPPSMLRYEEMTERWFPLANNLP 237
Cdd:cd18478  76 D--PYQDEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-111 1.96e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 153.87  E-value: 1.96e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726   4 EEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREAlsqeagGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLlgpr 83
Cdd:cd18319   1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES------GEEVVQLRGLSAPGLELVLDFINTSKVHESQG---- 70

                        90       100
                ....*....|....*....|....*...
gi 55749726  84 gekgggvDEDEEMDEVSLLSELVEAASF 111
Cdd:cd18319  71 -------DSTDTLEENELLEDLVEAASF 91
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
235-481 2.05e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.32  E-value: 2.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 235 NLPPDLVNVRGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPSTNEWLQVASMNQK-RSNFKLVAVNSKLYAIGG----- 308
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGftgan 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 309 ---QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTlfETCDVHIRKQQ 385
Cdd:COG3055  84 pssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT--QLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 386 M---VSVEETIYIVGGcLHELGPNRRSSQSEDMLTVQSYNTVtrqwlylkentsksglnltcALHNDGIYIMSRDVTLST 462
Cdd:COG3055 162 LaaaVLPDGKILVIGG-RNGSGFSNTWTTLAPLPTARAGHAA--------------------AVLGGKILVFGGESGFSD 220

                       250
                ....*....|....*....
gi 55749726 463 SLEhrvflKYNIFSDSWEA 481
Cdd:COG3055 221 EVE-----AYDPATNTWTA 234
 
Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 128-237 2.48e-52

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 172.65  E-value: 2.48e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 128 NNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSppqapgdvSLKQRLREARMTGTPVLVALGDFLGGPL 207
Cdd:cd18478   4 PNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPS--------SLKQQLRERRLRGTPALVALGDFLGTPL 75

                        90       100       110
                ....*....|....*....|....*....|
gi 55749726 208 AphPYQGEPPSMLRYEEMTERWFPLANNLP 237
Cdd:cd18478  76 D--PYQDEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-111 1.96e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 153.87  E-value: 1.96e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726   4 EEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREAlsqeagGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLlgpr 83
Cdd:cd18319   1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES------GEEVVQLRGLSAPGLELVLDFINTSKVHESQG---- 70

                        90       100
                ....*....|....*....|....*...
gi 55749726  84 gekgggvDEDEEMDEVSLLSELVEAASF 111
Cdd:cd18319  71 -------DSTDTLEENELLEDLVEAASF 91
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
235-481 2.05e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.32  E-value: 2.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 235 NLPPDLVNVRGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPSTNEWLQVASMNQK-RSNFKLVAVNSKLYAIGG----- 308
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGftgan 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 309 ---QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTlfETCDVHIRKQQ 385
Cdd:COG3055  84 pssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT--QLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 386 M---VSVEETIYIVGGcLHELGPNRRSSQSEDMLTVQSYNTVtrqwlylkentsksglnltcALHNDGIYIMSRDVTLST 462
Cdd:COG3055 162 LaaaVLPDGKILVIGG-RNGSGFSNTWTTLAPLPTARAGHAA--------------------AVLGGKILVFGGESGFSD 220

                       250
                ....*....|....*....
gi 55749726 463 SLEhrvflKYNIFSDSWEA 481
Cdd:COG3055 221 EVE-----AYDPATNTWTA 234
PHA03098 PHA03098
kelch-like protein; Provisional
 210-497 1.46e-25

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 109.86  E-value: 1.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  210 HPYQGEPPSMLRYEEMTERWFPLANNlppdlVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQ 289
Cdd:PHA03098 257 ITMSIFTYNYITNYSPLSEINTIIDI-----HYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIY 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  290 KRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQ-Y 364
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGiynsISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVEcF 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  365 CPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSsqsedmlTVQSYNTVTRQWlylkenTSKSGLNLT- 443
Cdd:PHA03098 412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYN-------IVESYNPVTNKW------TELSSLNFPr 478

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 55749726  444 -----CALHNDgIYIMSRDVTLSTSLEHRVflkYNIFSDSWEAFRRFPAFGHNLLVSSL 497
Cdd:PHA03098 479 inaslCIFNNK-IYVVGGDKYEYYINEIEV---YDDKTNTWTLFCKFPKVIGSLEKNIF 533
Kelch smart00612
Kelch domain;
302-344 9.23e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 54.10  E-value: 9.23e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 55749726    302 KLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKG 344
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 291-331 6.28e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 6.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 55749726   291 RSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLP 331
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 130-169 6.28e-08

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 50.42  E-value: 6.28e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55749726    130 CLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLL 169
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLEL 40
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 130-169 6.08e-06

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 44.84  E-value: 6.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 55749726   130 CLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLL 169
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLEL 40
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 7-69 5.86e-03

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 36.47  E-value: 5.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55749726     7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFI 69
Cdd:pfam00651  13 VTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI------TLDDVSPEDFEALLEFM 69
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 7-69 7.18e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 36.13  E-value: 7.18e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55749726      7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFI 69
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEI------YLDDVSPEDFRALLNFL 58
 
Name Accession Description Interval E-value
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 128-237 2.48e-52

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 172.65  E-value: 2.48e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 128 NNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSppqapgdvSLKQRLREARMTGTPVLVALGDFLGGPL 207
Cdd:cd18478   4 PNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPS--------SLKQQLRERRLRGTPALVALGDFLGTPL 75

                        90       100       110
                ....*....|....*....|....*....|
gi 55749726 208 AphPYQGEPPSMLRYEEMTERWFPLANNLP 237
Cdd:cd18478  76 D--PYQDEPWSMLRYDEVEQRWLPLANELP 103
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-111 1.96e-45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 153.87  E-value: 1.96e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726   4 EEMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREAlsqeagGPEVQQLRGLSAPGLRLVLDFINAGGAREGWLlgpr 83
Cdd:cd18319   1 EETVQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRES------GEEVVQLRGLSAPGLELVLDFINTSKVHESQG---- 70

                        90       100
                ....*....|....*....|....*...
gi 55749726  84 gekgggvDEDEEMDEVSLLSELVEAASF 111
Cdd:cd18319  71 -------DSTDTLEENELLEDLVEAASF 91
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
235-481 2.05e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.32  E-value: 2.05e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 235 NLPPDLVNVRGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPSTNEWLQVASMNQK-RSNFKLVAVNSKLYAIGG----- 308
Cdd:COG3055   5 SLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGftgan 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 309 ---QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTlfETCDVHIRKQQ 385
Cdd:COG3055  84 pssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT--QLAPLPTPRDH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 386 M---VSVEETIYIVGGcLHELGPNRRSSQSEDMLTVQSYNTVtrqwlylkentsksglnltcALHNDGIYIMSRDVTLST 462
Cdd:COG3055 162 LaaaVLPDGKILVIGG-RNGSGFSNTWTTLAPLPTARAGHAA--------------------AVLGGKILVFGGESGFSD 220

                       250
                ....*....|....*....
gi 55749726 463 SLEhrvflKYNIFSDSWEA 481
Cdd:COG3055 221 EVE-----AYDPATNTWTA 234
PHA03098 PHA03098
kelch-like protein; Provisional
 210-497 1.46e-25

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 109.86  E-value: 1.46e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  210 HPYQGEPPSMLRYEEMTERWFPLANNlppdlVNVRGYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQ 289
Cdd:PHA03098 257 ITMSIFTYNYITNYSPLSEINTIIDI-----HYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIY 331

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  290 KRSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQ-Y 364
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGiynsISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVEcF 411

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  365 CPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSsqsedmlTVQSYNTVTRQWlylkenTSKSGLNLT- 443
Cdd:PHA03098 412 SLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYN-------IVESYNPVTNKW------TELSSLNFPr 478

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 55749726  444 -----CALHNDgIYIMSRDVTLSTSLEHRVflkYNIFSDSWEAFRRFPAFGHNLLVSSL 497
Cdd:PHA03098 479 inaslCIFNNK-IYVVGGDKYEYYINEIEV---YDDKTNTWTLFCKFPKVIGSLEKNIF 533
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
280-454 8.43e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.50  E-value: 8.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 280 EWLQVASMNQKRSNFKLVAVNSKLYAIGGQ----AVSNVECYNPEQDAWNFVAPLPNPLAEFSAC-ECKGKIYVIGGYTT 354
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLsggsASNSFEVYDPATNTWSELAPLPGPPRHHAAAvAQDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 355 RDRNMNIL----QYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGClHELGPNRrssqsedmlTVQSYNTVTRQWly 430
Cdd:COG3055  82 ANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGW-DDGGNVA---------WVEVYDPATGTW-- 149

                       170       180       190
                ....*....|....*....|....*....|
gi 55749726 431 lkenTSKSGL-----NLTCALHNDG-IYIM 454
Cdd:COG3055 150 ----TQLAPLptprdHLAAAVLPDGkILVI 175
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
194-355 6.02e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.19  E-value: 6.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 194 PVLVALGD---FLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANnLPpdlVNVRGYGSAILDNYLFIVGGYRiTSQEISA 270
Cdd:COG3055  64 AAAVAQDGklyVFGGFTGANPSSTPLNDVYVYDPATNTWTKLAP-MP---TPRGGATALLLDGKIYVVGGWD-DGGNVAW 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 271 AHSYNPSTNEWLQVASMNQKRSNFK-LVAVNSKLYAIGGQAVS------------------------------------- 312
Cdd:COG3055 139 VEVYDPATGTWTQLAPLPTPRDHLAaAVLPDGKILVIGGRNGSgfsntwttlaplptaraghaaavlggkilvfggesgf 218

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 55749726 313 --NVECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYTTR 355
Cdd:COG3055 219 sdEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA02713 PHA02713
hypothetical protein; Provisional
 217-396 9.38e-15

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 76.59  E-value: 9.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  217 PSMLRYEEMTERwFPLANNLPPDLVNvrgYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKL 296
Cdd:PHA02713 272 PCILVYNINTME-YSVISTIPNHIIN---YASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSL 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  297 VAVNSKLYAIGGQAVSNV----ECYNPEQDAWNFVAPLPNPLAEFSACECKGKIYVIGGYT-----TRDRNMN------- 360
Cdd:PHA02713 348 AVIDDTIYAIGGQNGTNVertiECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehidyTSVHHMNsidmeed 427

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 55749726  361 ------ILQYCPSSDMW-TLFETCDVHIRKqQMVSVEETIYIV 396
Cdd:PHA02713 428 thssnkVIRYDTVNNIWeTLPNFWTGTIRP-GVVSHKDDIYVV 469
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 7-111 3.49e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 67.69  E-value: 3.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726   7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEaggpevQQLRGLSAPGLRLVLDFINaggaregwllgprgek 86
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAE------INLRDISPEDFRALLEFLY---------------- 58

                        90       100
                ....*....|....*....|....*
gi 55749726  87 GGGVDEDEEMdevslLSELVEAASF 111
Cdd:cd01165  59 GGKRDLDASN-----LLELLEAANF 78
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
323-481 1.04e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.48  E-value: 1.04e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 323 AWNFVAPLPNPLAEFSACECKGKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQ-QMVSVEETIYIVGGClh 401
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFGGF-- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 402 elgpNRRSSQSEDMLTVQSYNTVTRQWLYLkENTSKSGLNLTCALHNDGIYimsrdVTLSTSLEHRV--FLKYNIFSDSW 479
Cdd:COG3055  80 ----TGANPSSTPLNDVYVYDPATNTWTKL-APMPTPRGGATALLLDGKIY-----VVGGWDDGGNVawVEVYDPATGTW 149


                ..
gi 55749726 480 EA 481
Cdd:COG3055 150 TQ 151
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 128-169 3.42e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 55.36  E-value: 3.42e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 55749726 128 NNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLL 169
Cdd:cd14733   3 ENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLEL 44
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-70 7.47e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 55.51  E-value: 7.47e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55749726   5 EMVQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFIN 70
Cdd:cd18320   2 QKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEI------RLQGLSARGFRIMLRVLA 61
Kelch smart00612
Kelch domain;
302-344 9.23e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 54.10  E-value: 9.23e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 55749726    302 KLYAIGG----QAVSNVECYNPEQDAWNFVAPLPNPLAEFSACECKG 344
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 291-331 6.28e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 6.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 55749726   291 RSNFKLVAVNSKLYAIGG----QAVSNVECYNPEQDAWNFVAPLP 331
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
235-318 1.04e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 56.32  E-value: 1.04e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726 235 NLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAahsYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGGQA---- 310
Cdd:COG3055 189 TLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEA---YDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETkpgv 265

                        90
                ....*....|..
gi 55749726 311 ----VSNVECYN 318
Cdd:COG3055 266 rtplVTSAEVYD 277
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 130-169 6.28e-08

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 50.42  E-value: 6.28e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 55749726    130 CLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLL 169
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLEL 40
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-69 8.91e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 50.86  E-value: 8.91e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 55749726  12 EDRCYPVSKRKLIEQSDYFRALYRSGMREAlSQeaggpEVQQLRGLSAPGLRLVLDFI 69
Cdd:cd18255  26 DGQRFQAHKVVLASCSDYFRAMFTGGMRES-SQ-----DEIELKGVSAKGLKHILDFA 77
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-69 7.75e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 46.78  E-value: 7.75e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55749726   7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFI 69
Cdd:cd18186   4 VTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEI------ELDDVSPEAFEALLDYI 60
Kelch smart00612
Kelch domain;
255-300 1.21e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 45.24  E-value: 1.21e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 55749726    255 LFIVGGYrITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVN 300
Cdd:smart00612   2 IYVVGGF-DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
252-299 1.41e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.41e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 55749726   252 DNYLFIVGGYRITSQE-ISAAHSYNPSTNEWLQVASMNQKRSNFKLVAV 299
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 244-288 3.43e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 3.43e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 55749726   244 RGYGSAILDNYLFIVGGYRiTSQEISAAHSYNPSTNEWLQVASMN 288
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFD-GNQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 129-166 5.75e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 44.31  E-value: 5.75e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 55749726 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQF 166
Cdd:cd18463   6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEF 43
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 130-169 6.08e-06

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 44.84  E-value: 6.08e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 55749726   130 CLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLL 169
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLEL 40
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 129-169 1.52e-05

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 42.92  E-value: 1.52e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 55749726 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLL 169
Cdd:cd18497   5 NVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAEL 45
Kelch_6 pfam13964
Kelch motif;
245-291 1.91e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.94  E-value: 1.91e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 55749726   245 GYGSAILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASMNQKR 291
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_6 pfam13964
Kelch motif;
291-333 5.92e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.40  E-value: 5.92e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 55749726   291 RSNFKLVAVNSKLYAIGG-----QAVSNVECYNPEQDAWNFVAPLPNP 333
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGytnasPALNKLEVYNPLTKSWEELPPLPTP 49
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 128-166 6.27e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 41.54  E-value: 6.27e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 55749726 128 NNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQF 166
Cdd:cd18480   4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEF 42
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 27-78 6.29e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 42.49  E-value: 6.29e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 55749726  27 SDYFRALYRSGMREalSQEAggpeVQQLRGLSAPGLRLVLDFINAGGAREGW 78
Cdd:cd18263  36 SDYFRAMFTSGMKE--STQS----VVQLPTIPAKDLRLLISFAYSGILHLSW 81
PHA02790 PHA02790
Kelch-like protein; Provisional
 255-371 8.37e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 45.03  E-value: 8.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  255 LFIVGGYrITSQEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVNSKLYAIGG-QAVSNVECYNPEQDAWNFVAPLPNP 333
Cdd:PHA02790 274 VYLIGGW-MNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGlPNPTSVERWFHGDAAWVNMPSLLKP 352

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 55749726  334 LAEFSACECKGKIYVIGGYTTRDRNMNILqyCPSSDMW 371
Cdd:PHA02790 353 RCNPAVASINNVIYVIGGHSETDTTTEYL--LPNHDQW 388
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 129-189 2.53e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 39.67  E-value: 2.53e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55749726 129 NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQfhLLGSPPQAPGDVSLKQRLREAR 189
Cdd:cd18484   5 NCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPA--VYGRLSGAERELILRRRLEAGR 63
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-110 6.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 39.53  E-value: 6.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726   7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREalSQEAggpEVqQLRGLSAPGLRLVLDFINAGGAregwLLgprgek 86
Cdd:cd18287  25 VTFVVEEKRFPAHRVILAARSEYFRALLYGGMRE--SQQS---EI-ELKDTNAEAFKALLKYIYTGRL----TL------ 88

                        90       100
                ....*....|....*....|....*....
gi 55749726  87 gGGVDEDEEMDEVSL-----LSELVEAAS 110
Cdd:cd18287  89 -TDLKEDVLLDVLGLahqygFEELEAAIS 116
BACK_BTBD8 cd18490
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); ...
 130-174 7.58e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental process. It may also act as a protein-protein adaptor in a transcription complex and thus may be involved in brain development.


Pssm-ID: 350565  Cd Length: 64  Bit Score: 38.02  E-value: 7.58e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 55749726 130 CLEmyrLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLgsPPQ 174
Cdd:cd18490   8 CLP---LAHTFGLEDLYEKCLRWIAKHFAKVWSTKSFASL--PPE 47
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-69 9.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 39.40  E-value: 9.46e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 55749726  13 DRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFI 69
Cdd:cd18239  34 DETFPVHRAMMASASDYFKAMFTGGMKEQELMCI------KLHGVSKIGLKNIIDFI 84
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-69 1.08e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 39.39  E-value: 1.08e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 55749726  16 YPVSKRKLIEQSDYFRALYRSGMREAlsqeagGPEVQQLRGLSAPGLRLVLDFI 69
Cdd:cd18264  40 FPAHRSLLACSSDYFRALFKDYTQES------KARVIHLPVVSAAGLQRVLDFI 87
PLN02193 PLN02193
nitrile-specifier protein
 255-428 1.10e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 41.48  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  255 LFIVGGyRITSQEISAAHSYNPSTNEWLQVASMNQ---KRSNFKLVAVNSKLYAIGGQA----VSNVECYNPEQDAWNFV 327
Cdd:PLN02193 231 LYVFGG-RDASRQYNGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSatarLKTLDSYNIVDKKWFHC 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749726  328 AplpNPLAEFSACE------CKGKIYVIGGYTTRDRNmNILQYCPSSDMWTLFETCDVHIRKQQM---VSVEETIYIVGG 398
Cdd:PLN02193 310 S---TPGDSFSIRGgaglevVQGKVWVVYGFNGCEVD-DVHYYDPVQDKWTQVETFGVRPSERSVfasAAVGKHIVIFGG 385

                        170       180       190
                 ....*....|....*....|....*....|..
gi 55749726  399 clhELGPNRRSSQSEDMLTVQSY--NTVTRQW 428
Cdd:PLN02193 386 ---EIAMDPLAHVGPGQLTDGTFalDTETLQW 414
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-69 1.54e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 38.58  E-value: 1.54e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55749726   7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMrealsQEAGGPEVqQLRGLSAPGLRLVLDFI 69
Cdd:cd18242  24 VTLRVEGKEFPAHRIVLAACSDYFCAMFTSEM-----SEKGKSEV-ELQGLTASTMEILLDFV 80
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-72 1.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 38.54  E-value: 1.59e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55749726   7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSqeaggpEVQQLRGLSAPGLRLVLDFINAG 72
Cdd:cd18256  23 VQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSK------DVVQIHGVEPDIFHILLDFIYTG 82
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-69 1.79e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 38.46  E-value: 1.79e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55749726   7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAGGPevqqlrGLSAPGLRLVLDFI 69
Cdd:cd18240  20 VVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIP------GVSPEMMELIIEYA 76
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 331-373 1.89e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.00  E-value: 1.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 55749726   331 PNPLAEFSACECKGKIYVIGGYTTRDRNmnilqycPSSDMWTL 373
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQ-------PSDDVYVL 36
Kelch_4 pfam13418
Galactose oxidase, central domain;
244-287 2.09e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 2.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55749726   244 RGYGSA--ILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQVASM 287
Cdd:pfam13418   2 RAYHTStsIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-72 2.41e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 38.40  E-value: 2.41e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55749726   7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFINAG 72
Cdd:cd18244  33 VTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKI------HLKGLTATGFSHVLQFMYYG 92
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-72 3.62e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 37.95  E-value: 3.62e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55749726  12 EDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFINAG 72
Cdd:cd18266  33 DEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEV------ELVGASYIGLKAVIDFLYSS 87
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 19-72 5.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 35.95  E-value: 5.10e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 55749726  19 SKRKLIEQSDYFRALYRSGMREALSQEAGGPEVqqlrGLSAPGLRLVLDFINAG 72
Cdd:cd18190  14 VRKKIASLSRPFKAMLYGNFRESTSDCIDFEEN----GISIEAMRAVIDFSVTG 63
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 128-169 5.70e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 35.63  E-value: 5.70e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 55749726 128 NNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLL 169
Cdd:cd18493   3 NHAVSWLQYAKMCGHKELAEACLEFIAWNFEKVLKSPDWLNL 44
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 7-69 5.86e-03

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 36.47  E-value: 5.86e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55749726     7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFI 69
Cdd:pfam00651  13 VTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEI------TLDDVSPEDFEALLEFM 69
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 7-69 7.18e-03

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 36.13  E-value: 7.18e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55749726      7 VQIRLEDRCYPVSKRKLIEQSDYFRALYRSGMREALSQEAggpevqQLRGLSAPGLRLVLDFI 69
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEI------YLDDVSPEDFRALLNFL 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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