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Conserved domains on  [gi|557276737|ref|XP_006021492|]
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G2/mitotic-specific cyclin-B1 isoform X2 [Alligator sinensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 166-294 3.07e-85

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20565:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 129  Bit Score: 256.34  E-value: 3.07e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 166 CSEYVKDIYKYLRVLEEQQAIRPKFLLGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQL 245
Cdd:cd20565    1 CSEYVKDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 557276737 246 VGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20565   81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 299-419 1.10e-81

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410272  Cd Length: 121  Bit Score: 247.11  E-value: 1.10e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPV 378
Cdd:cd20569    1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 557276737 379 MQHMAKNVIQVNQGLTKRMTIKNKYASSKNVKISTLSQLNS 419
Cdd:cd20569   81 MQHMAKNVVKVNQGLTKHMTVKNKYASSKQMKISTLPQLNS 121
PDHac_trf_long super family cl36876
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 77-129 7.59e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


The actual alignment was detected with superfamily member TIGR01348:

Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 38.70  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 557276737   77 EPQPKAALKKEAKPTAEDKPAARKPAKAVEGTAEPlkEEEQAQEPAKLEPLSP 129
Cdd:TIGR01348 199 APAPASAQPAAQSPAATQPEPAAAPAAAKAQAPAP--QQAGTQNPAKVDHAAP 249
 
Name Accession Description Interval E-value
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 166-294 3.07e-85

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 256.34  E-value: 3.07e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 166 CSEYVKDIYKYLRVLEEQQAIRPKFLLGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQL 245
Cdd:cd20565    1 CSEYVKDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 557276737 246 VGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20565   81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 299-419 1.10e-81

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 247.11  E-value: 1.10e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPV 378
Cdd:cd20569    1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 557276737 379 MQHMAKNVIQVNQGLTKRMTIKNKYASSKNVKISTLSQLNS 419
Cdd:cd20569   81 MQHMAKNVVKVNQGLTKHMTVKNKYASSKQMKISTLPQLNS 121
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
161-412 5.30e-63

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 209.63  E-value: 5.30e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 161 SDPNLCSEYVKDIYKYLRVLEEQQAIRPKFLLG-KEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVS 239
Cdd:COG5024  172 EDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKqSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 240 KKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDFSLGRPLPLHFLRRASKIGEVDLEQH 319
Cdd:COG5024  252 LEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSR 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 320 TLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYM-AYAESDLLPVMQHMAKNvIQVNQGLTKRmt 398
Cdd:COG5024  332 TPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSgNYTNPDLKPLNESNKEN-LQNPSVHHDA-- 408

                        250
                 ....*....|....
gi 557276737 399 IKNKYASSKNVKIS 412
Cdd:COG5024  409 IFPKYPSPTFGKAS 422
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 172-297 4.72e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 181.18  E-value: 4.72e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737  172 DIYKYLRVLEEQQAIRPKFLLG-KEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTA 250
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 557276737  251 MFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDFSLG 297
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 299-417 2.82e-44

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 150.47  E-value: 2.82e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737  299 PLPLHFLRRASKIGEV--DLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLL 376
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 557276737  377 PVMQHMAKNVIQVNQGltKRMTIKNKYASSKNVKISTLSQL 417
Cdd:pfam02984  81 PCVKLLLELLLNAPSS--KLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 303-384 2.95e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.87  E-value: 2.95e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737   303 HFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYA-ESDLLPVMQH 381
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFtEEEILRMERL 80


                   ...
gi 557276737   382 MAK 384
Cdd:smart00385  81 LLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 206-290 4.39e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.48  E-value: 4.39e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737   206 DWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDnaYTKLQIRQME 285
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 557276737   286 MKILK 290
Cdd:smart00385  79 RLLLE 83
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 77-129 7.59e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 38.70  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 557276737   77 EPQPKAALKKEAKPTAEDKPAARKPAKAVEGTAEPlkEEEQAQEPAKLEPLSP 129
Cdd:TIGR01348 199 APAPASAQPAAQSPAATQPEPAAAPAAAKAQAPAP--QQAGTQNPAKVDHAAP 249
 
Name Accession Description Interval E-value
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 166-294 3.07e-85

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 256.34  E-value: 3.07e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 166 CSEYVKDIYKYLRVLEEQQAIRPKFLLGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQL 245
Cdd:cd20565    1 CSEYVKDIYAYLRQLEEEQAVRPKYLEGQEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 557276737 246 VGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20565   81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 299-419 1.10e-81

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 247.11  E-value: 1.10e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPV 378
Cdd:cd20569    1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 557276737 379 MQHMAKNVIQVNQGLTKRMTIKNKYASSKNVKISTLSQLNS 419
Cdd:cd20569   81 MQHMAKNVVKVNQGLTKHMTVKNKYASSKQMKISTLPQLNS 121
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 166-294 3.97e-79

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 240.51  E-value: 3.97e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 166 CSEYVKDIYKYLRVLEEQQAIRPKFLLG-KEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQ 244
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGqPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 557276737 245 LVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20507   81 LVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 162-294 2.01e-70

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 218.58  E-value: 2.01e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 162 DPNLCSEYVKDIYKYLRVLEEQQAIRPKFLLGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKK 241
Cdd:cd20566    1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYLDGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 557276737 242 TLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20566   81 KLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
161-412 5.30e-63

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 209.63  E-value: 5.30e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 161 SDPNLCSEYVKDIYKYLRVLEEQQAIRPKFLLG-KEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVS 239
Cdd:COG5024  172 EDPLMVPEYASDIFEYLLKLELIDLPNPNYLIKqSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 240 KKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDFSLGRPLPLHFLRRASKIGEVDLEQH 319
Cdd:COG5024  252 LEKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSR 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 320 TLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYM-AYAESDLLPVMQHMAKNvIQVNQGLTKRmt 398
Cdd:COG5024  332 TPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSgNYTNPDLKPLNESNKEN-LQNPSVHHDA-- 408

                        250
                 ....*....|....
gi 557276737 399 IKNKYASSKNVKIS 412
Cdd:COG5024  409 IFPKYPSPTFGKAS 422
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 299-417 1.39e-62

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 197.80  E-value: 1.39e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPV 378
Cdd:cd20570    1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPI 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 557276737 379 MQHMAKNVIQVNQGLTKRMTIKNKYASSKNVKISTLSQL 417
Cdd:cd20570   81 MQHMAKNVVKVNEGLTKHVAVKNKYASSKLMKISTIPQL 119
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 299-411 9.54e-61

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 192.83  E-value: 9.54e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPV 378
Cdd:cd20509    1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 557276737 379 MQHMAKNVIQVNQglTKRMTIKNKYASSKNVKI 411
Cdd:cd20509   81 VQKMAKLVVKSQT--SKYQAVKNKYSSSKFMRI 111
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 172-297 4.72e-56

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 181.18  E-value: 4.72e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737  172 DIYKYLRVLEEQQAIRPKFLLG-KEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTA 250
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQqPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 557276737  251 MFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDFSLG 297
Cdd:pfam00134  81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 168-294 9.97e-54

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 175.13  E-value: 9.97e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 168 EYVKDIYKYLRVLEEQQaiRPKFLLGK---EVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQ 244
Cdd:cd20504    1 EYADDIYEYLRESELKH--RPKPDYMRkqpDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQ 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 557276737 245 LVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20504   79 LVGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 162-294 1.79e-51

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 169.90  E-value: 1.79e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 162 DPNLCSEYVKDIYKYLRVLEEQQAIRPKFL--LGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVS 239
Cdd:cd20562    1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMekIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 557276737 240 KKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20562   81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 162-294 9.17e-50

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 165.16  E-value: 9.17e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 162 DPNLCSEYVKDIYKYLRVLEEQQAIRPKFLL-GKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSK 240
Cdd:cd20568    1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDdQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 557276737 241 KTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20568   81 NKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 168-294 2.67e-49

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 164.44  E-value: 2.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 168 EYVKDIYKYLRVLEEQQAIRPKFLLGK-EVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLV 246
Cdd:cd20567   20 EYVEDIYSFYRKVEPESCVPPYYMSQQpDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLV 99

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 557276737 247 GVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20567  100 GVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 162-294 5.44e-49

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 163.58  E-value: 5.44e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 162 DPNLCSEYVKDIYKYLRVLEEQQAIRPKFLLGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKK 241
Cdd:cd20508    9 DPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKE 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 557276737 242 TLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20508   89 KLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 299-417 2.82e-44

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 150.47  E-value: 2.82e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737  299 PLPLHFLRRASKIGEV--DLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLL 376
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 557276737  377 PVMQHMAKNVIQVNQGltKRMTIKNKYASSKNVKISTLSQL 417
Cdd:pfam02984  81 PCVKLLLELLLNAPSS--KLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 171-294 1.25e-40

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 141.30  E-value: 1.25e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 171 KDIYKYLRVLEEQQAiRPKFLLGK--EVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFL--QNNiVSKKTLQLV 246
Cdd:cd20519    6 EEVWDLMLKKEELYK-RDRDFLNRhpSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLstQTN-VPKTQLQLI 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 557276737 247 GVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20519   84 GITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 167-294 1.95e-40

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 140.58  E-value: 1.95e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 167 SEYVKDIYKYLRVLEEQQAIRPKFLLGK-EVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQL 245
Cdd:cd20561    2 PDYHEDIHTYLREMEVKCKPKVGYMKKQpDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 557276737 246 VGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20561   82 VGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 167-294 9.57e-37

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 131.89  E-value: 9.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 167 SEYVKDIYKYLRvlEEQQAIRPKFLLGK---EVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTL 243
Cdd:cd20560   34 PEYAEDIHQYLR--EAELKHRPKPGYMRkqpDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKL 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 557276737 244 QLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20560  112 QLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAF 162
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 201-296 1.89e-33

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 120.89  E-value: 1.89e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 201 RAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQ 280
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                         90
                 ....*....|....*.
gi 557276737 281 IRQMEMKILKALDFSL 296
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 200-292 2.92e-33

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 120.12  E-value: 2.92e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 200 MRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKL 279
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 557276737 280 QIRQMEMKILKAL 292
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 299-404 1.46e-31

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 116.61  E-value: 1.46e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPV 378
Cdd:cd20510    1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                         90       100
                 ....*....|....*....|....*.
gi 557276737 379 MQHMakNVIQVNQGLTKRMTIKNKYA 404
Cdd:cd20510   81 VRKL--NAMLTKPPNKKLKTVRSKYS 104
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 301-416 1.10e-30

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 114.25  E-value: 1.10e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 301 PLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPVMQ 380
Cdd:cd20512    2 PMNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGDWNDNLVHYSGYTESQLIPCAD 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 557276737 381 HMAKNVIqvnQGLTKRMTIKNKYASSKNVKISTLSQ 416
Cdd:cd20512   82 IMLEYLV---KPIKHHDAFFKKYSSKKFLKASIFVR 114
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 169-294 6.78e-28

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 107.27  E-value: 6.78e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 169 YVKDiykyLRVLEEQQAIRPKfllgkevtgnMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFL--QNNIVsKKTLQLV 246
Cdd:cd20579   25 YLRD----KNFLQKHPLLQPK----------MRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMatQENVV-KTRLQLI 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 557276737 247 GVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDF 294
Cdd:cd20579   90 GISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 200-292 1.92e-26

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 103.39  E-value: 1.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 200 MRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFL--QNNIvSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYT 277
Cdd:cd20580   42 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMltQKNI-NKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACS 120

                         90
                 ....*....|....*
gi 557276737 278 KLQIRQMEMKILKAL 292
Cdd:cd20580  121 EDDILDMELIILKAL 135
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 304-407 7.86e-23

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 92.70  E-value: 7.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 304 FLRR---ASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPVMQ 380
Cdd:cd20506    6 FLRRflrAAQASVPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAADLKPCVQ 85

                         90       100
                 ....*....|....*....|....*..
gi 557276737 381 HMAKNVIQVNQGLTKrmTIKNKYASSK 407
Cdd:cd20506   86 ALHDLQLNASGSSLQ--AVREKYKQHK 110
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 299-388 9.70e-23

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 91.60  E-value: 9.70e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTP-TLQHYMAYAESDLLP 377
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPqLLQLVTGYSENDLQE 80

                         90
                 ....*....|.
gi 557276737 378 VMQHMAKNVIQ 388
Cdd:cd20537   81 CAKELLELLAQ 91
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 299-415 1.23e-19

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 83.89  E-value: 1.23e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDG-GEWTPTLQHYMAYAESDLLP 377
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKtPEWTSTLEFHTGYSESQLME 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 557276737 378 VMQHMAKnvIQVNQGLTKRMTIKNKYASSKNVKISTLS 415
Cdd:cd20511   81 CARLMVR--LHSKAGTGKLTAVYKKYSSSKFGAVALLP 116
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 303-384 2.95e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.87  E-value: 2.95e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737   303 HFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYA-ESDLLPVMQH 381
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYFtEEEILRMERL 80


                   ...
gi 557276737   382 MAK 384
Cdd:smart00385  81 LLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 206-290 4.39e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.48  E-value: 4.39e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737   206 DWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDnaYTKLQIRQME 285
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                   ....*
gi 557276737   286 MKILK 290
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 200-292 1.45e-17

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 77.36  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 200 MRAILIDWLVQV-QMKfRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTK 278
Cdd:cd20521    3 MRYILVDWLVEVaTMK-DFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYKY 81

                         90
                 ....*....|....
gi 557276737 279 LQIRQMEMKILKAL 292
Cdd:cd20521   82 EDVVRMMGEIVAAL 95
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 204-295 4.29e-16

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 73.19  E-value: 4.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 204 LIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMYP--PEIGDFAFVTDNAYTKLQI 281
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                         90
                 ....*....|....
gi 557276737 282 RQMEMKILKALDFS 295
Cdd:cd20559   82 IQMEMHILNTLNWD 95
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 299-408 1.34e-15

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 72.33  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYE-MVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLP 377
Cdd:cd20505    1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANHTLGNEVWPQKLARSTGYSLEDLLP 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 557276737 378 VMQHMAKNVIQVNQglTKRMTIKNKYASSKN 408
Cdd:cd20505   81 CLRDLHRTFLNAPS--SPQQAIREKYKSSKY 109
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 180-292 1.56e-14

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 70.79  E-value: 1.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 180 LEEQQAIRPKFLLG--KEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKY 257
Cdd:cd20515   33 LEERYLPSASYFKCvqTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKL 112

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 557276737 258 EEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKAL 292
Cdd:cd20515  113 KETIPLTAEKLCIYTDNSITLQELLDWELLVLTKL 147
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 160-292 5.71e-14

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 68.86  E-value: 5.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 160 GSDPNLCSEyvKDIYKYLRVLEEQQAIRPKFL--LGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNI 237
Cdd:cd20575   15 GPDPRLLGD--QRVLQNLLRLEERYVPRVSYFqcVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVP 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 557276737 238 VSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKAL 292
Cdd:cd20575   93 TRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKL 147
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 199-294 1.63e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 66.09  E-value: 1.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 199 NMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEE--MYPPEIGDF-AFVTDNA 275
Cdd:cd20528    5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEEldDNIPKISDLnRYLCNSV 84

                         90
                 ....*....|....*....
gi 557276737 276 YTKLQIRQMEMKILKALDF 294
Cdd:cd20528   85 YSKQEYLQMELLILEFFQW 103
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 204-287 7.56e-13

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 63.58  E-value: 7.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 204 LIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEmYPPEIGDFAFVTDnaYTKLQIRQ 283
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELRK 78


                 ....
gi 557276737 284 MEMK 287
Cdd:cd00043   79 AEKE 82
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 162-292 1.32e-12

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 65.00  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 162 DPNLCSEYVkdiYKYLRVLEEQQAIRPKFL--LGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVS 239
Cdd:cd20573   17 DANLLNDRV---LQTMLKAEETCLPSVSYFkcVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTK 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 557276737 240 KKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKAL 292
Cdd:cd20573   94 KSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKL 146
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 299-408 5.50e-12

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 62.15  E-value: 5.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 299 PLPLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYE-MVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLP 377
Cdd:cd20564    1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLESLKP 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 557276737 378 VMQHMAKNVIQVNQglTKRMTIKNKYASSKN 408
Cdd:cd20564   81 CLMDLHQTYLKAPQ--HAQQSIREKYKNSKY 109
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 322-382 6.90e-11

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 58.92  E-value: 6.90e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557276737 322 AKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGE-WTPTLQHYMAYAESDLLPVMQHM 382
Cdd:cd20529   40 ADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPtWPEELEKLTGYSEDELEPCVELL 101
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 304-414 1.01e-10

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 59.05  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 304 FLRRASKIGEVDLEQHTLAKYLMELSIVDYE-MVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPVMQHM 382
Cdd:cd20563    6 FLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVPCLSDL 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 557276737 383 AKNVIQVNQglTKRMTIKNKYASSKNVKISTL 414
Cdd:cd20563   86 HKACLGAPH--RPQQAIREKYKGSKYMQVSLL 115
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 196-292 2.40e-10

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 57.19  E-value: 2.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 196 VTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMYPPEIGDFAFVTDNA 275
Cdd:cd20517    1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                         90
                 ....*....|....*..
gi 557276737 276 YTKLQIRQMEMKILKAL 292
Cdd:cd20517   81 FTNLELINQEKDILEAL 97
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 207-356 1.73e-08

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 55.51  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 207 WLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKYEEMyPPEIGDFAFVTDNAYTKL------Q 280
Cdd:COG5333   51 LIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDT-PRDISIESFEARDLWSEEpkssreR 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557276737 281 IRQMEMKILKALDFSLGRPLPLHFLRRASKIGEVDL--EQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILD 356
Cdd:COG5333  130 ILEYEFELLEALDFDLHVHHPYKYLEGFLKDLQEKDkyKLLQIAWKIINDALRTDLCLLYPPHIIALAALLIACEVLG 207
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 178-295 2.50e-08

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 52.69  E-value: 2.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 178 RVLEEQQAIRPKFL--------LGKEVTGNMRAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVT 249
Cdd:cd20574   25 RVLQNLLTIEERYLpqcsyfkcVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAV 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 557276737 250 AMFVASKYEEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKALDFS 295
Cdd:cd20574  105 CMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 205-296 4.80e-08

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 50.77  E-value: 4.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 205 IDWLVQVQMKFRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKY--EEMYPPEIGDFAFVTDNAYTKLQIR 282
Cdd:cd20526    6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVL 85

                         90
                 ....*....|....
gi 557276737 283 QMEMKILKALDFSL 296
Cdd:cd20526   86 RMERIILDKLHWDL 99
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 201-293 7.60e-07

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 47.31  E-value: 7.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 201 RAILIDWLVQVQMKFRLLQETMYLTVAIIDRFLQN-NIVSKKT--LQLVGVTAMFVASKYEEMYPPEIGDF----AFVTD 273
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSyDLPKDKPwmLQLLAVACLSLAAKMEETDVPLLVDLqveePKYVF 81

                         90       100
                 ....*....|....*....|
gi 557276737 274 NAYTklqIRQMEMKILKALD 293
Cdd:cd20543   82 EAKT---IQRMELLVLSTLE 98
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 301-380 3.22e-06

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 45.09  E-value: 3.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 301 PLHFLRRASKIGEVDLEQHTLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILDGGEWTPTLQHYMAYAESDLLPVMQ 380
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKELRKAEK 81
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 321-412 3.97e-04

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 39.91  E-value: 3.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 321 LAKYLMELSIVDYEMVHYPPSQIAAAAFCLAlKILDGGE--WTPTLQHYMAYAESDLLPVMQHM-----AKNVIQVNQGl 393
Cdd:cd20522    2 LASYICELSLLHTELGRYSPAVIAASCLLLA-RVLLNQAlpWPSQLEEFTGFSLEDLLSCVLHLhkkcfHEDSPKDYRN- 79

                         90
                 ....*....|....*....
gi 557276737 394 TKRMTIKNKYASSKNVKIS 412
Cdd:cd20522   80 VSLTAVKQRYEDERFLSIS 98
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 324-350 1.08e-03

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 38.42  E-value: 1.08e-03
                         10        20
                 ....*....|....*....|....*..
gi 557276737 324 YLMELSIVDYEMVHYPPSQIAAAAFCL 350
Cdd:cd20520   43 QLLDLCILDIGSLQFSYSVLAASALYL 69
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 320-356 2.91e-03

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 36.94  E-value: 2.91e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 557276737 320 TLAKYLMELSIVDYEMVHYPPSQIAAAAFCLALKILD 356
Cdd:cd20722   31 ALARYLAELSLADYAFNQYPPSLLAICSLELADRMLQ 67
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 215-292 2.97e-03

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 37.11  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557276737 215 FRLLQETMYLTVAIIDRFLQNNIVSKKTLQLVGVTAMFVASKY--EEMYPPEIGDFAFVTDNAYTKLQIRQMEMKILKAL 292
Cdd:cd20583   16 FGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRMEKIILEKL 95
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 77-129 7.59e-03

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 38.70  E-value: 7.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 557276737   77 EPQPKAALKKEAKPTAEDKPAARKPAKAVEGTAEPlkEEEQAQEPAKLEPLSP 129
Cdd:TIGR01348 199 APAPASAQPAAQSPAATQPEPAAAPAAAKAQAPAP--QQAGTQNPAKVDHAAP 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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