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Conserved domains on  [gi|55665845|emb|CAH70182|]
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Notch homolog 2 (Drosophila) [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1659-1740 3.07e-48

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411986  Cd Length: 82  Bit Score: 166.86  E-value: 3.07e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1659 LSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLK 1738
Cdd:cd21703    1 LPYPLVSVTSEPLKETKFNLLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKENSNRKRREPVGQDAVGMK 80


                 ..
gi 55665845 1739 NL 1740
Cdd:cd21703   81 NL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1851-2066 5.21e-44

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 5.21e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1851 AEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1930
Cdd:COG0666   61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1931 RNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKE 2010
Cdd:COG0666  141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845 2011 ETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2066
Cdd:COG0666  220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1539-1594 1.41e-26

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 104.13  E-value: 1.41e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845   1539 PENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYG 1594
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1618-1673 2.67e-13

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 66.53  E-value: 2.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   1618 VAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLS--YPLVSVVSESLTP 1673
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDlpYPIKEVRSEPPPP 58
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 182-218 1.26e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.34  E-value: 1.26e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC 218
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1423-1456 3.15e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 54.07  E-value: 3.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1423 ATCLSQYCADKARDGVCDEACNSHACQWDGGDCS 1456
Cdd:pfam00066    2 PNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 2068-2422 6.49e-09

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 61.13  E-value: 6.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2068 TPSPPGTVLTSALSPVICGPNRSflslkhTPmgkksrrPSAKSTMPTS---LPNLAKEAKDAKGSRRKKSLSEKvqlSES 2144
Cdd:pfam17823   99 EPATREGAADGAASRALAAAASS------SP-------SSAAQSLPAAiaaLPSEAFSAPRAAACRANASAAPR---AAI 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2145 SVTLSPVDSLESPHTYVSDTTSSPMITSpgilqASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVS-- 2222
Cdd:pfam17823  163 AAASAPHAASPAPRTAASSTTAASSTTA-----ASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSpa 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2223 -----------------QLLSHHHIVSPGSGSAGSLSRLHPVPVPAdwmnrmevNETQYNEMFGMVLAPAEGTHPGIAPQ 2285
Cdd:pfam17823  238 agtvtaavgtvtpaalaTLAAAAGTVASAAGTINMGDPHARRLSPA--------KHMPSDTMARNPAAPMGAQAQGPIIQ 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2286 SRPPEGKHITTPR-EPLPPIVTFQLIPKGSIAQPAGA----PQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQ 2360
Cdd:pfam17823  310 VSTDQPVHNTAGEpTPSPSNTTLEPNTPKSVASTNLAvvttTKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPT 389

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   2361 QDG------QVAQTILPAYHPFPASVGkyPTPPSQHSYASSNAAERTPShsghLQGEHPYLTPSPESP 2422
Cdd:pfam17823  390 QGAagpgilLAPEQVATEATAGTASAG--PTPRSSGDPKTLAMASCQLS----TQGQYLVVTTDPLTP 451
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1501-1534 1.81e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.81e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1501 KTCKYDkYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:pfam00066    2 PNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1061 1.95e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.95e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845 1026 INECSS-HPCLNEGTCVDGLGTYRCSCPLGYTGKNCQ 1061
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 873-909 1.97e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.97e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  873 DIDECISK-PCMNHGLCHNTQGSYMCECPPGFSGMDCE 909
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-793 7.11e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.11e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  757 DKNECLS-NPCQNGGTCDNLVNGYRCTCKKGFKGYNCQ 793
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1185 7.47e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.47e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 55665845 1151 DECAS-NPCQHGATCSDFIGGYRCECVPGYQGVNCE 1185
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 456-492 9.73e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.73e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFKGVHCE 492
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-530 1.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.04e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  495 INECQS-NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ 530
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1225-1262 2.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.22e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845 1225 NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCE 1262
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-985 3.55e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.55e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  949 DMNECLSE-PCKNGGTCSDYVNSYTCKCQAGFDGVHCE 985
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 911-947 3.72e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.72e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  911 DIDDCL-ANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 415-454 5.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 5.73e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 55665845  415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE 454
Cdd:cd00054    1 DIDECAS--GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 5.90e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.90e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  682 DIDECAS-NPCRKGATCINGVNGFRCICPEGPHHPSC 717
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 608-643 8.08e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.08e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPGTSGVNCE 643
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-568 8.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFTGVLCE 568
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1188-1223 8.91e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.91e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845 1188 VDECQ-NQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223
Cdd:cd00054    2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1022 1.75e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.75e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  987 NINECTESS-CFNGGTCVDGINSFSCLCPVGFTGSFC 1022
Cdd:cd00054    1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-831 3.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.38e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  795 NIDECAS-NPCLNQGTCFDDISGYTCHCVLPYTGKNCQ 831
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1463-1497 1.66e-05

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 43.67  E-value: 1.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 55665845   1463 WANCSSPlPCWDYINN-QCDELCNTVECLFDNFECQ 1497
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNgVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 260-296 2.58e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.58e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  260 NIDDC-PNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCT 296
Cdd:cd00054    1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 298-335 2.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.60e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  298 DVDECLlQPNACQNGGTCANRNGGYGCVCVNGWSGDDC 335
Cdd:cd00054    1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 7.28e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.28e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  645 NFDDCAS-NPC-IHGICMDGINRYSCVCSPGFTGQRC 679
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-604 1.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  570 NIDNCD-PDPC-HHGQCQDGIDSYTCICNPGYMGAIC 604
Cdd:cd00054    1 DIDECAsGNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1312-1343 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.54e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 55665845 1312 PCLNGGTCavaSNMPDGFICRCPPGFSGARCQ 1343
Cdd:cd00054   10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1117-1147 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.89e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 55665845 1117 EHLCQHSGVCINAGNTHYCQCPLGYTGSYCE 1147
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1264-1302 3.55e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.55e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 55665845 1264 DINECLS-NPCSSEGSldCIQLTNDYLCVCRSAFTGRHCE 1302
Cdd:cd00054    1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1659-1740 3.07e-48

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 166.86  E-value: 3.07e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1659 LSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLK 1738
Cdd:cd21703    1 LPYPLVSVTSEPLKETKFNLLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKENSNRKRREPVGQDAVGMK 80


                 ..
gi 55665845 1739 NL 1740
Cdd:cd21703   81 NL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1851-2066 5.21e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 5.21e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1851 AEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1930
Cdd:COG0666   61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1931 RNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKE 2010
Cdd:COG0666  141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845 2011 ETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2066
Cdd:COG0666  220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1539-1594 1.41e-26

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 104.13  E-value: 1.41e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845   1539 PENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYG 1594
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1948-2040 1.34e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 1.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   1948 LILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNgANRDMQDNKeETPLFLAAREGSYEAAK 2027
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 55665845   2028 ILLDHFANRDITD 2040
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1794-2030 1.46e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 1.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1794 LEA-ADIRRTPSLALTPP----QAEQEVDVL--------DVNVRGPDGCTPLMlASLRGGSSDlsdededaedssANIIT 1860
Cdd:PHA03095   70 LEAgADVNAPERCGFTPLhlylYNATTLDVIkllikagaDVNAKDKVGRTPLH-VYLSGFNIN------------PKVIR 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1861 DLVYQGASLQAqTDRTGEMALHLAARYSRADAA--KRLLDAGADANAQDNMGRCPLH--AAVAADAQGVFQILIRnRVTD 1936
Cdd:PHA03095  137 LLLRKGADVNA-LDLYGMTPLAVLLKSRNANVEllRLLIDAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIR-AGCD 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1937 LDARMNDGTTPLILAARLAV--EGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPL 2014
Cdd:PHA03095  215 PAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294

                         250
                  ....*....|....*.
gi 55665845  2015 FLAAREGSYEAAKILL 2030
Cdd:PHA03095  295 SLMVRNNNGRAVRAAL 310
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1618-1673 2.67e-13

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 66.53  E-value: 2.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   1618 VAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLS--YPLVSVVSESLTP 1673
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDlpYPIKEVRSEPPPP 58
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 182-218 1.26e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.34  E-value: 1.26e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC 218
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1423-1456 3.15e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 54.07  E-value: 3.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1423 ATCLSQYCADKARDGVCDEACNSHACQWDGGDCS 1456
Cdd:pfam00066    2 PNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 2068-2422 6.49e-09

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 61.13  E-value: 6.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2068 TPSPPGTVLTSALSPVICGPNRSflslkhTPmgkksrrPSAKSTMPTS---LPNLAKEAKDAKGSRRKKSLSEKvqlSES 2144
Cdd:pfam17823   99 EPATREGAADGAASRALAAAASS------SP-------SSAAQSLPAAiaaLPSEAFSAPRAAACRANASAAPR---AAI 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2145 SVTLSPVDSLESPHTYVSDTTSSPMITSpgilqASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVS-- 2222
Cdd:pfam17823  163 AAASAPHAASPAPRTAASSTTAASSTTA-----ASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSpa 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2223 -----------------QLLSHHHIVSPGSGSAGSLSRLHPVPVPAdwmnrmevNETQYNEMFGMVLAPAEGTHPGIAPQ 2285
Cdd:pfam17823  238 agtvtaavgtvtpaalaTLAAAAGTVASAAGTINMGDPHARRLSPA--------KHMPSDTMARNPAAPMGAQAQGPIIQ 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2286 SRPPEGKHITTPR-EPLPPIVTFQLIPKGSIAQPAGA----PQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQ 2360
Cdd:pfam17823  310 VSTDQPVHNTAGEpTPSPSNTTLEPNTPKSVASTNLAvvttTKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPT 389

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   2361 QDG------QVAQTILPAYHPFPASVGkyPTPPSQHSYASSNAAERTPShsghLQGEHPYLTPSPESP 2422
Cdd:pfam17823  390 QGAagpgilLAPEQVATEATAGTASAG--PTPRSSGDPKTLAMASCQLS----TQGQYLVVTTDPLTP 451
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1418-1455 8.15e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 53.10  E-value: 8.15e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 55665845    1418 PSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDC 1455
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
182-219 1.14e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.63  E-value: 1.14e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT-GQYCD 219
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1501-1534 1.81e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.81e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1501 KTCKYDkYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:pfam00066    2 PNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1061 1.95e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.95e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845 1026 INECSS-HPCLNEGTCVDGLGTYRCSCPLGYTGKNCQ 1061
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 873-909 1.97e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.97e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  873 DIDECISK-PCMNHGLCHNTQGSYMCECPPGFSGMDCE 909
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2068-2422 2.14e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2068 TPSPPGTvltSALSPVICGPnrsflslkhTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESS-- 2145
Cdd:PHA03247 2615 SPLPPDT---HAPDPPPPSP---------SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqr 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2146 -------VTLSPVDSLESPHTYVSDTTSSPMITSPGI---------LQASPNPMLATAAPPAP----VHAQHALSFSNLH 2205
Cdd:PHA03247 2683 prrraarPTVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaaRQASPALPAAPAPPAVPagpaTPGGPARPARPPT 2762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2206 EMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSL-SRLHPVPVPADWMNRmevnetqyNEMFGMVLAPAEGTHPGIAP 2284
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLpSPWDPADPPAAVLAP--------AAALPPAASPAGPLPPPTSA 2834

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2285 QSRPPegkhiTTPREPLPPIVTFQ--LIPKGSIAQ--PAGAPQPQSTCP----------PAVAGPLPTMYQIP-EMARLP 2349
Cdd:PHA03247 2835 QPTAP-----PPPPGPPPPSLPLGgsVAPGGDVRRrpPSRSPAAKPAAParppvrrlarPAVSRSTESFALPPdQPERPP 2909

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845  2350 SVAFPTAMMPQQDGQVAQTILPAYHPFPASvgKYPTPPSQHSYASSNAAERTPS-HSGHL-QGEHP---YLTPSPESP 2422
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRP--QPPLAPTTDPAGAGEPSGAVPQpWLGALvPGRVAvprFRVPQPAPS 2985
EGF_CA smart00179
Calcium-binding EGF-like domain;
873-909 5.77e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 5.77e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     873 DIDECISK-PCMNHGLCHNTQGSYMCECPPGFS-GMDCE 909
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-793 7.11e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.11e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  757 DKNECLS-NPCQNGGTCDNLVNGYRCTCKKGFKGYNCQ 793
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1185 7.47e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.47e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 55665845 1151 DECAS-NPCQHGATCSDFIGGYRCECVPGYQGVNCE 1185
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 456-492 9.73e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.73e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFKGVHCE 492
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-530 1.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.04e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  495 INECQS-NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ 530
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1225-1262 2.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.22e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845 1225 NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCE 1262
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-985 3.55e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.55e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  949 DMNECLSE-PCKNGGTCSDYVNSYTCKCQAGFDGVHCE 985
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1496-1534 3.71e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.71e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1496 CQGNSKTCKyDKYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 911-947 3.72e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.72e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  911 DIDDCL-ANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 415-454 5.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 5.73e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 55665845  415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE 454
Cdd:cd00054    1 DIDECAS--GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 5.90e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.90e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  682 DIDECAS-NPCRKGATCINGVNGFRCICPEGPHHPSC 717
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 608-643 8.08e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.08e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPGTSGVNCE 643
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-568 8.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFTGVLCE 568
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1188-1223 8.91e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.91e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845 1188 VDECQ-NQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223
Cdd:cd00054    2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1061 9.59e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 9.59e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1025 EINECSS-HPCLNEGTCVDGLGTYRCSCPLGYT-GKNCQ 1061
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1151-1185 1.02e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 1.02e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 55665845    1151 DECAS-NPCQHGATCSDFIGGYRCECVPGYQ-GVNCE 1185
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
682-711 1.48e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.48e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 55665845     682 DIDECAS-NPCRKGATCINGVNGFRCICPEG 711
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
456-492 1.71e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.71e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFK-GVHCE 492
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1022 1.75e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.75e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  987 NINECTESS-CFNGGTCVDGINSFSCLCPVGFTGSFC 1022
Cdd:cd00054    1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1872-2046 2.11e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.09  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1872 QTDRTGEMALHLAARYSRADAAKRLLD-AGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDL-----DARMNDGT 1945
Cdd:cd22192   12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA-APELvnepmTSDLYQGE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1946 TPLILAARLAVEGMVAELINCQADVN--------------AVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEE 2011
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARGADVVspratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 55665845 2012 TPLFLAAREGSYEAAKILLDHFANRDITDH---MDRLP 2046
Cdd:cd22192  171 TVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA smart00179
Calcium-binding EGF-like domain;
757-793 2.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     757 DKNECLS-NPCQNGGTCDNLVNGYRCTCKKGFK-GYNCQ 793
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-831 3.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.38e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  795 NIDECAS-NPCLNQGTCFDDISGYTCHCVLPYTGKNCQ 831
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
494-530 3.90e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.90e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     494 EINECQS-NPCVNNGQCVDKVNRFQCLCPPGFT-GPVCQ 530
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
949-985 4.14e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.14e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     949 DMNECLSE-PCKNGGTCSDYVNSYTCKCQAGF-DGVHCE 985
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
415-454 5.08e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 5.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 55665845     415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGY-AGPRCE 454
Cdd:smart00179    1 DIDECAS--GNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1225-1262 5.77e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.77e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1225 NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGF-AGERCE 1262
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1187-1223 8.55e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 8.55e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1187 EVDECQ-NQPCQNGGTCIDLVNHFKCSCPPG-TRGLLCE 1223
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
608-643 1.33e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.33e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 55665845     608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPG-TSGVNCE 643
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1463-1497 1.66e-05

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 43.67  E-value: 1.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 55665845   1463 WANCSSPlPCWDYINN-QCDELCNTVECLFDNFECQ 1497
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNgVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 260-296 2.58e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.58e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  260 NIDDC-PNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCT 296
Cdd:cd00054    1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 298-335 2.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.60e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  298 DVDECLlQPNACQNGGTCANRNGGYGCVCVNGWSGDDC 335
Cdd:cd00054    1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1029-1059 2.67e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 2.67e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845   1029 CSSHPCLNEGTCVDGLGTYRCSCPLGYTGKN 1059
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
911-947 2.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.83e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     911 DIDDCL-ANPCQNGGSCMDGVNTFSCLCLPGFT-GDKCQ 947
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
532-568 2.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.92e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFT-GVLCE 568
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
987-1022 3.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 3.38e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 55665845     987 NINECTESS-CFNGGTCVDGINSFSCLCPVGFT-GSFC 1022
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
182-212 5.20e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 5.20e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    182 DVNECDIPGH-CQHGGTCLNLPGSYQCQCPQG 212
Cdd:pfam07645    1 DVDECATGTHnCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 536-564 8.92e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 8.92e-05
                           10        20
                   ....*....|....*....|....*....
gi 55665845    536 CSSTPCLNGAKCIDHPNGYECQCATGFTG 564
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
795-831 1.42e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.42e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     795 NIDECAS-NPCLNQGTCFDDISGYTCHCVLPYT-GKNCQ 831
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 799-829 1.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 1.70e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    799 CASNPCLNQGTCFDDISGYTCHCVLPYTGKN 829
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1153-1183 3.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 3.70e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845   1153 CASNPCQHGATCSDFIGGYRCECVPGYQGVN 1183
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 498-527 4.17e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.17e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 55665845    498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGP 527
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 915-944 4.25e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.25e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 55665845    915 CLANPCQNGGSCMDGVNTFSCLCLPGFTGD 944
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
298-335 5.09e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.09e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     298 DVDECLlQPNACQNGGTCANRNGGYGCVCVNGWS-GDDC 335
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
682-711 7.23e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 7.23e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    682 DIDECAS--NPCRKGATCINGVNGFRCICPEG 711
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 7.28e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.28e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  645 NFDDCAS-NPC-IHGICMDGINRYSCVCSPGFTGQRC 679
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 761-789 7.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.58e-04
                           10        20
                   ....*....|....*....|....*....
gi 55665845    761 CLSNPCQNGGTCDNLVNGYRCTCKKGFKG 789
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 953-983 9.60e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 9.60e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    953 CLSEPCKNGGTCSDYVNSYTCKCQAGFDGVH 983
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-604 1.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  570 NIDNCD-PDPC-HHGQCQDGIDSYTCICNPGYMGAIC 604
Cdd:cd00054    1 DIDECAsGNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
260-296 1.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.21e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     260 NIDDC-PNHRCQNGGVCVDGVNTYNCRCPPQWT-GQFCT 296
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1459-1496 1.35e-03

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 38.46  E-value: 1.35e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1459 MENPWANCSSPlPCWDYINN-QCDELCNTVECLFDNFEC 1496
Cdd:smart00004    1 PQDPWSRCEDA-QCWDKFGDgVCDEECNNAECLWDGGDC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
873-902 1.53e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.53e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    873 DIDECIS--KPCMNHGLCHNTQGSYMCECPPG 902
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1312-1343 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.54e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 55665845 1312 PCLNGGTCavaSNMPDGFICRCPPGFSGARCQ 1343
Cdd:cd00054   10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1191-1219 1.84e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.84e-03
                           10        20
                   ....*....|....*....|....*....
gi 55665845   1191 CQNQPCQNGGTCIDLVNHFKCSCPPGTRG 1219
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 460-490 2.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.17e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    460 CHSDPCQNDATCLDKIGGFTCLCMPGFKGVH 490
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
298-329 2.86e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.86e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    298 DVDECLLQPNACQNGGTCANRNGGYGCVCVNG 329
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1117-1147 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.89e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 55665845 1117 EHLCQHSGVCINAGNTHYCQCPLGYTGSYCE 1147
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1264-1302 3.55e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.55e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 55665845 1264 DINECLS-NPCSSEGSldCIQLTNDYLCVCRSAFTGRHCE 1302
Cdd:cd00054    1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 611-641 4.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    611 CYSSPCLNDGRCIDLVNGYQCNCQPGTSGVN 641
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 423-452 4.96e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.96e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 55665845    423 NSNPCEHAGKCVNTDGAFHCECLKGYAGPR 452
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PHA02887 PHA02887
EGF-like protein; Provisional
 629-681 5.24e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 39.14  E-value: 5.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   629 YQCNCQPGTSGVNCEINFDDCAS---NPCIHGICMDGIN--RYSCVCSPGFTGQRCNI 681
Cdd:PHA02887   66 YKENANAQNFKRKNSMFFEKCKNdfnDFCINGECMNIIDldEKFCICNKGYTGIRCDE 123
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 991-1021 6.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 6.79e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    991 CTESSCFNGGTCVDGINSFSCLCPVGFTGSF 1021
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1308-1341 7.87e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1308 CPQMPCLNGGTCavaSNMPDGFICRCPPGFSGAR 1341
Cdd:pfam00008    1 CAPNPCSNGGTC---VDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 649-678 9.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 9.13e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    649 CASNPCIH-GICMDGINRYSCVCSPGFTGQR 678
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 264-292 9.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 9.40e-03
                           10        20
                   ....*....|....*....|....*....
gi 55665845    264 CPNHRCQNGGVCVDGVNTYNCRCPPQWTG 292
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
 
Name Accession Description Interval E-value
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1659-1740 3.07e-48

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 166.86  E-value: 3.07e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1659 LSYPLVSVVSESLTPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLK 1738
Cdd:cd21703    1 LPYPLVSVTSEPLKETKFNLLYLLAVAVAIILLILLLGVLVAKRKRKHGPLWFPEGFILNKENSNRKRREPVGQDAVGMK 80


                 ..
gi 55665845 1739 NL 1740
Cdd:cd21703   81 NL 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1851-2066 5.21e-44

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 162.82  E-value: 5.21e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1851 AEDSSANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1930
Cdd:COG0666   61 AALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1931 RNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKE 2010
Cdd:COG0666  141 EAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDG 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845 2011 ETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2066
Cdd:COG0666  220 KTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1866-2066 3.79e-43

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 160.50  E-value: 3.79e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1866 GASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDLDARMNDGT 1945
Cdd:COG0666   43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1946 TPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEA 2025
Cdd:COG0666  122 TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 55665845 2026 AKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLDEYN 2066
Cdd:COG0666  202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAG 242
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1819-2041 1.86e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.94  E-value: 1.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1819 LDVNVRGPDGCTPLMLAslrggssdlsdededAEDSSANIITDLVYQGASLQAQtDRTGEMALHLAARYSRADAAKRLLD 1898
Cdd:COG0666   78 ADINAKDDGGNTLLHAA---------------ARNGDLEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLE 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1899 AGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGK 1978
Cdd:COG0666  142 AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55665845 1979 SALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDH 2041
Cdd:COG0666  221 TALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1858-2062 1.01e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 133.16  E-value: 1.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1858 IITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDL 1937
Cdd:COG0666    2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-DI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1938 DARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLA 2017
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 55665845 2018 AREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLL 2062
Cdd:COG0666  161 AANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1660-1740 9.10e-32

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 119.79  E-value: 9.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1660 SYPLVSVVSESL----TPERTQLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAV 1735
Cdd:cd21701    1 PYPIYSVRSEPGpatkTTPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRRHGTLWFPEGFPRTRASRRSRRRDPVGQDSV 80


                 ....*
gi 55665845 1736 GLKNL 1740
Cdd:cd21701   81 GLKNL 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1820-2014 4.83e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.07  E-value: 4.83e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1820 DVNVRGPDGCTPLMLASLRGgssdlsdededaedsSANIITDLVYQGASLQAQtDRTGEMALHLAARYSRADAAKRLLDA 1899
Cdd:COG0666  112 DVNARDKDGETPLHLAAYNG---------------NLEIVKLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEA 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1900 GADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKS 1979
Cdd:COG0666  176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 55665845 1980 ALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPL 2014
Cdd:COG0666  255 ALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1661-1741 1.64e-27

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 107.91  E-value: 1.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1661 YPLVSVVSESLTPERT--QLLYLLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRDASNHKRREPVGQDAVGLK 1738
Cdd:cd21704    7 YPIKEVRGEKLEPPPPpvRLLPLLGVAAVILLVILVLGVLVARRKREHSTLWFPEGFFLKKESSNKNRREPVGQDALGMK 86


                 ...
gi 55665845 1739 NLS 1741
Cdd:cd21704   87 HIA 89
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1539-1594 1.41e-26

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 104.13  E-value: 1.41e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845   1539 PENLAEGTLVIVVLMPPEQLLQDARSFLRALGTLLHTNLRIKRDSQGELMVYPYYG 1594
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1659-1740 3.24e-19

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 84.37  E-value: 3.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1659 LSYPLVSVVSESLTPERT--------QLLYLLAVAVVIILFIILLGVIMA-KRKRKHGSLWLPEGFTLRRDASNHKRREP 1729
Cdd:cd21705    1 LPFPLLAVTVEEAEKDPQlvaaqlpwPLVCSSVAGVLALVLGALLGVQLIrRRQREHGALWLPPGFARHRDPNPHRRREP 80

                         90
                 ....*....|.
gi 55665845 1730 VGQDAVGLKNL 1740
Cdd:cd21705   81 VGEDAIGLKPL 91
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1666-1740 1.03e-18

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 82.53  E-value: 1.03e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845 1666 VVSESLTPERTQLLYLLAVAVVIILFIILLGV---IMAKRKRKHGSLWLPEGFTLrRDASNHKRREPVGQDAVGLKNL 1740
Cdd:cd21702    2 VKSETVEPPPPSQLYPMYVVLAALVLLAFVGVgvlVSRKRRREHGQLWFPEGFKV-SEPSKKKRREPVGEDSVGLKPL 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1948-2040 1.34e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 1.34e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   1948 LILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNgANRDMQDNKeETPLFLAAREGSYEAAK 2027
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 55665845   2028 ILLDHFANRDITD 2040
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1881-1974 4.41e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 4.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   1881 LHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDarmNDGTTPLILAARLAVEGMV 1960
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 55665845   1961 AELINCQADVNAVD 1974
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1794-2030 1.46e-14

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 78.91  E-value: 1.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1794 LEA-ADIRRTPSLALTPP----QAEQEVDVL--------DVNVRGPDGCTPLMlASLRGGSSDlsdededaedssANIIT 1860
Cdd:PHA03095   70 LEAgADVNAPERCGFTPLhlylYNATTLDVIkllikagaDVNAKDKVGRTPLH-VYLSGFNIN------------PKVIR 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1861 DLVYQGASLQAqTDRTGEMALHLAARYSRADAA--KRLLDAGADANAQDNMGRCPLH--AAVAADAQGVFQILIRnRVTD 1936
Cdd:PHA03095  137 LLLRKGADVNA-LDLYGMTPLAVLLKSRNANVEllRLLIDAGADVYAVDDRFRSLLHhhLQSFKPRARIVRELIR-AGCD 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1937 LDARMNDGTTPLILAARLAV--EGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPL 2014
Cdd:PHA03095  215 PAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294

                         250
                  ....*....|....*.
gi 55665845  2015 FLAAREGSYEAAKILL 2030
Cdd:PHA03095  295 SLMVRNNNGRAVRAAL 310
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1618-1673 2.67e-13

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 66.53  E-value: 2.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   1618 VAGSKVFLEIDNRQCVQDSDHCFKNTDAAAALLASHAIQGTLS--YPLVSVVSESLTP 1673
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDlpYPIKEVRSEPPPP 58
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1981-2062 5.81e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.68  E-value: 5.81e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   1981 LHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHfANRDITDHmDRLPRDVARDRMHHDIVR 2060
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVK 78


                   ..
gi 55665845   2061 LL 2062
Cdd:pfam12796   79 LL 80
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1877-2037 1.34e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 72.33  E-value: 1.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1877 GEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVA-ADAQGVFQILIRNRVTDlDARMNDGTTPLILAARLA 1955
Cdd:PHA02875   35 GISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEeGDVKAVEELLDLGKFAD-DVFYKDGMTPLHLATILK 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1956 VEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN 2035
Cdd:PHA02875  114 KLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN 193


                  ..
gi 55665845  2036 RD 2037
Cdd:PHA02875  194 ID 195
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1841-2038 3.41e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 71.45  E-value: 3.41e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1841 SSDLSDEDEDAEDSS--ANIITDLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAV 1918
Cdd:PHA02878  130 TIDLVYIDKKSKDDIieAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAV 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1919 AADAQGVFQILIRNRvTDLDARMNDGTTPL-ILAARLAVEGMVAELINCQADVNAVDD-HGKSALHwaAAVNNVEATLLL 1996
Cdd:PHA02878  210 KHYNKPIVHILLENG-ASTDARDKCGNTPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLL 286

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 55665845  1997 LKNGANRDMQDNKEETPLFLAAREGS-YEAAKILLDH-----FANRDI 2038
Cdd:PHA02878  287 LEYGADINSLNSYKLTPLSSAVKQYLcINIGRILISNicllkRIKPDI 334
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1889-2035 1.73e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.28  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1889 RADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQ---GVFQILIRNRVtDLDARMNDGTTPLILAARLA-VEGMVAELI 1964
Cdd:PHA03095   26 TVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGA-DVNAPERCGFTPLHLYLYNAtTLDVIKLLI 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55665845  1965 NCQADVNAVDDHGKSALHWAAAVNNVEATL--LLLKNGANRDMQDNKEETPL--FLAAREGSYEAAKILLDHFAN 2035
Cdd:PHA03095  105 KAGADVNAKDKVGRTPLHVYLSGFNINPKVirLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGAD 179
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1820-2008 4.24e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.77  E-value: 4.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1820 DVNVRGPDGCTPLMLASLRggssdlsdededaEDSSANIITDLVYQGASLQAQTDRtGEMALHLAARYSRADA--AKRLL 1897
Cdd:PHA03100   98 NVNAPDNNGITPLLYAISK-------------KSNSYSIVEYLLDNGANVNIKNSD-GENLLHLYLESNKIDLkiLKLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1898 DAGADANAQDNMgrcplhaavaadaqgvfQILIRNRVtDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHG 1977
Cdd:PHA03100  164 DKGVDINAKNRV-----------------NYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG 225

                         170       180       190
                  ....*....|....*....|....*....|.
gi 55665845  1978 KSALHWAAAVNNVEATLLLLKNGANRDMQDN 2008
Cdd:PHA03100  226 DTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1879-2062 4.59e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 67.77  E-value: 4.59e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1879 MALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLH-----AAVAADAQGVFQILIrNRVTDLDARMNDGTTPLILAAR 1953
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLL-EYGANVNAPDNNGITPLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1954 LAVEG--MVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLL------------------LLKNGANRDMQDNKEETP 2013
Cdd:PHA03100  116 KKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinaknrvnyLLSYGVPINIKDVYGFTP 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 55665845  2014 LFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLL 2062
Cdd:PHA03100  196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
 1660-1733 2.83e-10

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 58.81  E-value: 2.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1660 SYPLVSVVSESLT-----PERTQLLYLLAVAVVIILFIILLGV-IMAKRKRKHGSLWLPEGFTLRRDASNH---KRREPV 1730
Cdd:cd21706    1 DFPIYQVRGEDPPdpppePPPSNLTYVVIGVVVVLLIGLLLGVlVTTQRKRARGITWFPEGFFTTSSSQRRrrsRRRGPD 80


                 ...
gi 55665845 1731 GQD 1733
Cdd:cd21706   81 GQE 83
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1801-2058 3.15e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.86  E-value: 3.15e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1801 RTPSLA-LTPPQAEQEVDVLDVNVRGPdgcTPLMLASLRGgssdlsdedEDAEDssaniITDLVYQGASLQAqTDRTGEM 1879
Cdd:PHA02876  282 QAPSLSrLVPKLLERGADVNAKNIKGE---TPLYLMAKNG---------YDTEN-----IRTLIMLGADVNA-ADRLYIT 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1880 ALHLAARYSR-ADAAKRLLDAGADANAQDNMGRCPLHAAVAADAqgvfqILIRNRVTDLDARMNDGTTPLILAARLAVEG 1958
Cdd:PHA02876  344 PLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNN-----VVIINTLLDYGADIEALSQKIGTALHFALCG 418

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1959 M-----VAELINCQADVNAVDDHGKSALHWAAAVN-NVEATLLLLKNGANRDMQDNKEETPLFLAAreGSYEAAKILLDH 2032
Cdd:PHA02876  419 TnpymsVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHY 496

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 55665845  2033 FA--------NRDITDHMDRLPRDVA----RDRMHHDI 2058
Cdd:PHA02876  497 GAelrdsrvlHKSLNDNMFSFRYIIAhiciQDFIRHDI 534
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1874-2046 5.99e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.21  E-value: 5.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1874 DRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDLDARMNDGTTPL---IL 1950
Cdd:PHA02874  154 DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH-GNHIMNKCKNGFTPLhnaII 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1951 AARLAVEgmvaELINcQADVNAVDDHGKSALHWAAAVN-NVEATLLLLKNGANRDMQDNKEETPLFLAARegSYEAAKIL 2029
Cdd:PHA02874  233 HNRSAIE----LLIN-NASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFK--YINKDPVI 305

                         170
                  ....*....|....*..
gi 55665845  2030 LDHFANRDITDHMDRLP 2046
Cdd:PHA02874  306 KDIIANAVLIKEADKLK 322
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 182-218 1.26e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 55.34  E-value: 1.26e-09
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC 218
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1878-2035 1.42e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 1.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1878 EMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVE 1957
Cdd:PHA02876  241 DLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYD 320

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1958 GM-VAELINCQADVNAVDDHGKSALHWAAAVN-NVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFAN 2035
Cdd:PHA02876  321 TEnIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1423-1456 3.15e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 54.07  E-value: 3.15e-09
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1423 ATCLSQYCADKARDGVCDEACNSHACQWDGGDCS 1456
Cdd:pfam00066    2 PNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1820-1998 4.21e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.58  E-value: 4.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1820 DVNVRGPDGCTPLMlASLRggSSDLSDEdedaedssanIITDLVYQGASLQAQTDRtGEMALHLAARYSRADAA--KRLL 1897
Cdd:PHA03095  144 DVNALDLYGMTPLA-VLLK--SRNANVE----------LLRLLIDAGADVYAVDDR-FRSLLHHHLQSFKPRARivRELI 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1898 DAGADANAQDNMGRCPLHAAVAADAQG---VFQILIRNrvTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVD 1974
Cdd:PHA03095  210 RAGCDPAATDMLGNTPLHSMATGSSCKrslVLPLLIAG--ISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287

                         170       180
                  ....*....|....*....|....
gi 55665845  1975 DHGKSALHWAAAVNNVEATLLLLK 1998
Cdd:PHA03095  288 SDGNTPLSLMVRNNNGRAVRAALA 311
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 2068-2422 6.49e-09

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 61.13  E-value: 6.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2068 TPSPPGTVLTSALSPVICGPNRSflslkhTPmgkksrrPSAKSTMPTS---LPNLAKEAKDAKGSRRKKSLSEKvqlSES 2144
Cdd:pfam17823   99 EPATREGAADGAASRALAAAASS------SP-------SSAAQSLPAAiaaLPSEAFSAPRAAACRANASAAPR---AAI 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2145 SVTLSPVDSLESPHTYVSDTTSSPMITSpgilqASPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVS-- 2222
Cdd:pfam17823  163 AAASAPHAASPAPRTAASSTTAASSTTA-----ASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSpa 237

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2223 -----------------QLLSHHHIVSPGSGSAGSLSRLHPVPVPAdwmnrmevNETQYNEMFGMVLAPAEGTHPGIAPQ 2285
Cdd:pfam17823  238 agtvtaavgtvtpaalaTLAAAAGTVASAAGTINMGDPHARRLSPA--------KHMPSDTMARNPAAPMGAQAQGPIIQ 309

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2286 SRPPEGKHITTPR-EPLPPIVTFQLIPKGSIAQPAGA----PQPQSTCPPAVAGPLPTMYQIPEMARLPSVAFPTAMMPQ 2360
Cdd:pfam17823  310 VSTDQPVHNTAGEpTPSPSNTTLEPNTPKSVASTNLAvvttTKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPT 389

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   2361 QDG------QVAQTILPAYHPFPASVGkyPTPPSQHSYASSNAAERTPShsghLQGEHPYLTPSPESP 2422
Cdd:pfam17823  390 QGAagpgilLAPEQVATEATAGTASAG--PTPRSSGDPKTLAMASCQLS----TQGQYLVVTTDPLTP 451
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1418-1455 8.15e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 53.10  E-value: 8.15e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 55665845    1418 PSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDC 1455
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
182-219 1.14e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.63  E-value: 1.14e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     182 DVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFT-GQYCD 219
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1884-2035 1.72e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 59.59  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1884 AARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRV----------------------TDLDARM 1941
Cdd:PHA02874   42 AIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVdtsilpipciekdmiktildcgIDVNIKD 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1942 NDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREG 2021
Cdd:PHA02874  122 AELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201

                         170
                  ....*....|....
gi 55665845  2022 SYEAAKILLDHFAN 2035
Cdd:PHA02874  202 DYACIKLLIDHGNH 215
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1501-1534 1.81e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.81e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1501 KTCKYDkYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:pfam00066    2 PNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1026-1061 1.95e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.95e-08
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845 1026 INECSS-HPCLNEGTCVDGLGTYRCSCPLGYTGKNCQ 1061
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 873-909 1.97e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 1.97e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  873 DIDECISK-PCMNHGLCHNTQGSYMCECPPGFSGMDCE 909
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2068-2422 2.14e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 2.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2068 TPSPPGTvltSALSPVICGPnrsflslkhTPMGKKSRRPSAKSTMPTSLPNLAKEAKDAKGSRRKKSLSEKVQLSESS-- 2145
Cdd:PHA03247 2615 SPLPPDT---HAPDPPPPSP---------SPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqr 2682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2146 -------VTLSPVDSLESPHTYVSDTTSSPMITSPGI---------LQASPNPMLATAAPPAP----VHAQHALSFSNLH 2205
Cdd:PHA03247 2683 prrraarPTVGSLTSLADPPPPPPTPEPAPHALVSATplppgpaaaRQASPALPAAPAPPAVPagpaTPGGPARPARPPT 2762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2206 EMQPLAHGASTVLPSVSQLLSHHHIVSPGSGSAGSL-SRLHPVPVPADWMNRmevnetqyNEMFGMVLAPAEGTHPGIAP 2284
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLpSPWDPADPPAAVLAP--------AAALPPAASPAGPLPPPTSA 2834

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2285 QSRPPegkhiTTPREPLPPIVTFQ--LIPKGSIAQ--PAGAPQPQSTCP----------PAVAGPLPTMYQIP-EMARLP 2349
Cdd:PHA03247 2835 QPTAP-----PPPPGPPPPSLPLGgsVAPGGDVRRrpPSRSPAAKPAAParppvrrlarPAVSRSTESFALPPdQPERPP 2909

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845  2350 SVAFPTAMMPQQDGQVAQTILPAYHPFPASvgKYPTPPSQHSYASSNAAERTPS-HSGHL-QGEHP---YLTPSPESP 2422
Cdd:PHA03247 2910 QPQAPPPPQPQPQPPPPPQPQPPPPPPPRP--QPPLAPTTDPAGAGEPSGAVPQpWLGALvPGRVAvprFRVPQPAPS 2985
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1873-2011 3.49e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 59.11  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1873 TDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIR-NRVTDLDArmndGTTPLILA 1951
Cdd:PLN03192  554 GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfASISDPHA----AGDLLCTA 629

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1952 ARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEE 2011
Cdd:PLN03192  630 AKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
Ank_4 pfam13637
Ankyrin repeats (many copies);
1979-2030 3.94e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.51  E-value: 3.94e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 55665845   1979 SALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILL 2030
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA smart00179
Calcium-binding EGF-like domain;
873-909 5.77e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 5.77e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     873 DIDECISK-PCMNHGLCHNTQGSYMCECPPGFS-GMDCE 909
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 757-793 7.11e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.11e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  757 DKNECLS-NPCQNGGTCDNLVNGYRCTCKKGFKGYNCQ 793
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1874-2059 7.31e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.28  E-value: 7.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1874 DRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTdLDARMNDGTTPLILAAR 1953
Cdd:PHA02874  121 DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHNAAE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1954 LAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNnvEATLLLLKNGANRDMQDNKEETPLFLAAR-EGSYEAAKILLDH 2032
Cdd:PHA02874  200 YGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN--RSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYH 277

                         170       180
                  ....*....|....*....|....*..
gi 55665845  2033 FANRDITDHMDRLPRDVARDRMHHDIV 2059
Cdd:PHA02874  278 KADISIKDNKGENPIDTAFKYINKDPV 304
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1151-1185 7.47e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.47e-08
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 55665845 1151 DECAS-NPCQHGATCSDFIGGYRCECVPGYQGVNCE 1185
Cdd:cd00054    3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 456-492 9.73e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 9.73e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFKGVHCE 492
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-530 1.04e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.04e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  495 INECQS-NPCVNNGQCVDKVNRFQCLCPPGFTGPVCQ 530
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2068-2407 1.83e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.26  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2068 TPSPPGTVLTSALsPVICGPNRSFLSLKHTPMGKKSR------------RPSAKSTMPTSLPNLAKEAKDAKGSRRKKSL 2135
Cdd:PHA03247 2707 TPEPAPHALVSAT-PLPPGPAAARQASPALPAAPAPPavpagpatpggpARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2136 SEKVQLSESSVTL-SPVDSLESPHTYVSDTTSSPMITSPGILQASPNPMLATAAPPAPVHAQhalsfsnlhemQPLAHGA 2214
Cdd:PHA03247 2786 PAVASLSESRESLpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP-----------PSLPLGG 2854

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2215 StvlpsvsqllshhhiVSPGsgsaGSLSRLHPVPVPADwmnrmevnetqynemfgmvlAPAEGTHPGIAPQSRPPEGKhi 2294
Cdd:PHA03247 2855 S---------------VAPG----GDVRRRPPSRSPAA--------------------KPAAPARPPVRRLARPAVSR-- 2893

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2295 TTPREPLPPivtfqlIPKGSIAQPAGAPQPQSTcPPAVAGPLPTMyQIPEMARLPSVAFP---TAMMPQQDGQVAQTILP 2371
Cdd:PHA03247 2894 STESFALPP------DQPERPPQPQAPPPPQPQ-PQPPPPPQPQP-PPPPPPRPQPPLAPttdPAGAGEPSGAVPQPWLG 2965

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 55665845  2372 AYHPFPASVGKYPTPPSQHSYASSnaAERTPSHSGH 2407
Cdd:PHA03247 2966 ALVPGRVAVPRFRVPQPAPSREAP--ASSTPPLTGH 2999
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1857-2044 2.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.83  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1857 NIITDLVYQGASLQAQTDRtGEMALHLAARYSRADAA--KRLLDAGADANAQDNMGRCPLHAAVAA--DAQGVFQILIRN 1932
Cdd:PHA03100   87 EIVKLLLEYGANVNAPDNN-GITPLLYAISKKSNSYSivEYLLDNGANVNIKNSDGENLLHLYLESnkIDLKILKLLIDK 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1933 RVtDLDARMNdgttplilaarlavegmVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEET 2012
Cdd:PHA03100  166 GV-DINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                         170       180       190
                  ....*....|....*....|....*....|..
gi 55665845  2013 PLFLAAREGSYEAAKILLDHFANrdiTDHMDR 2044
Cdd:PHA03100  228 PLHIAILNNNKEIFKLLLNNGPS---IKTIIE 256
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1225-1262 2.22e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 2.22e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845 1225 NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCE 1262
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 949-985 3.55e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.55e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  949 DMNECLSE-PCKNGGTCSDYVNSYTCKCQAGFDGVHCE 985
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2101-2422 3.65e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.93  E-value: 3.65e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2101 KKSRRPSAKS--TMPTSLPNLAKEAKDAKGSRRK---KSLSEKVQLSESSVTLSPvdSLESPHTYVSDTTSSP----MIT 2171
Cdd:pfam03154   92 EEPERATAKKskTQEISRPNSPSEGEGESSDGRSvndEGSSDPKDIDQDNRSTSP--SIPSPQDNESDSDSSAqqqiLQT 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2172 SPGILQA-SPNPMLATAAPPAPVHAQHALSFSNLHEMQPLAHGASTVLPSVSQ-LLSHHHIVSPGSgsagslsRLHPVPV 2249
Cdd:pfam03154  170 QPPVLQAqSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQsTAAPHTLIQQTP-------TLHPQRL 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2250 PadwmnrmevneTQYNEMFGMVLAPAEgthPGIAPQSRPPEGKHitTPREPLP--------------PIVTFQLIPKGSI 2315
Cdd:pfam03154  243 P-----------SPHPPLQPMTQPPPP---SQVSPQPLPQPSLH--GQMPPMPhslqtgpshmqhpvPPQPFPLTPQSSQ 306

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   2316 AQ-------------------PAGAPQPQSTCPPAvAGPLPTM-YQIPEMARLPSVAFPTAMMPQQDGQVAQTILPAYHP 2375
Cdd:pfam03154  307 SQvppgpspaapgqsqqrihtPPSQSQLQSQQPPR-EQPLPPApLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQ 385

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 55665845   2376 FPASVgkyPTPPSQHSYASSNAAERTPSHSGHLQ--GEHPYLTPSPESP 2422
Cdd:pfam03154  386 MNSNL---PPPPALKPLSSLSTHHPPSAHPPPLQlmPQSQQLPPPPAQP 431
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1496-1534 3.71e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.71e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1496 CQGNSKTCKyDKYCADHFKDNHCDQGCNSEECGWDGLDC 1534
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 911-947 3.72e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.72e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  911 DIDDCL-ANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947
Cdd:cd00054    1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 415-454 5.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 5.73e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 55665845  415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGYAGPRCE 454
Cdd:cd00054    1 DIDECAS--GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 682-717 5.90e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 5.90e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  682 DIDECAS-NPCRKGATCINGVNGFRCICPEGPHHPSC 717
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA03379 PHA03379
EBNA-3A; Provisional
 2100-2395 6.98e-07

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 55.06  E-value: 6.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2100 GKKSRRPsakstmPTSLPNLAKE--AKDAKGSRRKKSLSEKVQLSESSVTLSPVDsLESPHTYVSDTTSspmiTSPGILQ 2177
Cdd:PHA03379  373 GTKRKRP------PIFLRRLHRLllMRAGKLTERAREALEKASEPTYGTPRPPVE-KPRPEVPQSLETA----TSHGSAQ 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2178 aSPNPMLATAAPPAPVHAQHALsfsnlhEMQPLAHGASTVLPSvsqllshhhiVSPGSGSAGSLS--RLHPVPVPADWMN 2255
Cdd:PHA03379  442 -VPEPPPVHDLEPGPLHDQHSM------APCPVAQLPPGPLQD----------LEPGDQLPGVVQdgRPACAPVPAPAGP 504

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2256 RMEVNETQYNEMFGMVLAPAEGTHPGIAPQSRPPEGkhITTPREPLPPIVTFQlipkgSIAQPAGAPQPQSTCPPAVAGP 2335
Cdd:PHA03379  505 IVRPWEASLSQVPGVAFAPVMPQPMPVEPVPVPTVA--LERPVCPAPPLIAMQ-----GPGETSGIVRVRERWRPAPWTP 577

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845  2336 LP--TMYQIP---EMARLPSVAFP-TAMMPQQDGQVAQtiLPAYHPFpasvgKYPTPPSQHSYASS 2395
Cdd:PHA03379  578 NPprSPSQMSvrdRLARLRAEAQPyQASVEVQPPQLTQ--VSPQQPM-----EYPLEPEQQMFPGS 636
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 608-643 8.08e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.08e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPGTSGVNCE 643
Cdd:cd00054    2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 532-568 8.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.48e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFTGVLCE 568
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1965-2017 8.65e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 8.65e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 55665845   1965 NCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLA 2017
Cdd:pfam13857    4 HGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1188-1223 8.91e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.91e-07
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845 1188 VDECQ-NQPCQNGGTCIDLVNHFKCSCPPGTRGLLCE 1223
Cdd:cd00054    2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1820-1907 9.51e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.96  E-value: 9.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845   1820 DVNVRGPDGCTPLMLASLRGgssdlsdededaedsSANIITDLVYQGASLQAQTDRTgemALHLAARYSRADAAKRLLDA 1899
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNG---------------HLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIVKLLLEK 83


                   ....*...
gi 55665845   1900 GADANAQD 1907
Cdd:pfam12796   84 GADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1881-2035 9.57e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.30  E-value: 9.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1881 LHLAARY-SRADAAKRLLDAGADANAQDNMGRCPLH--AAVAADAQGVFQILIRNrvTDLDARMNDGTTPLILAARL-AV 1956
Cdd:PHA02876  277 LHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYlmAKNGYDTENIRTLIMLG--ADVNAADRLYITPLHQASTLdRN 354

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1957 EGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPL-FLAAREGSYEAAKILLDHFAN 2035
Cdd:PHA02876  355 KDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALhFALCGTNPYMSVKTLIDRGAN 434
EGF_CA smart00179
Calcium-binding EGF-like domain;
1025-1061 9.59e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 9.59e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1025 EINECSS-HPCLNEGTCVDGLGTYRCSCPLGYT-GKNCQ 1061
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1151-1185 1.02e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 1.02e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 55665845    1151 DECAS-NPCQHGATCSDFIGGYRCECVPGYQ-GVNCE 1185
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1862-2063 1.17e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.91  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1862 LVYQGASLQAQtDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNRvtdldARM 1941
Cdd:PHA02876  164 LLEGGADVNAK-DIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR-----SNI 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1942 NDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATL-LLLKNGANRDMQDNKEETPLFLAARE 2020
Cdd:PHA02876  238 NKNDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVpKLLERGADVNAKNIKGETPLYLMAKN 317

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 55665845  2021 G-SYEAAKILLDHFANRDITDHMDRLPRDVAR--DRMHHDIVRLLD 2063
Cdd:PHA02876  318 GyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLE 363
EGF_CA smart00179
Calcium-binding EGF-like domain;
682-711 1.48e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.48e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 55665845     682 DIDECAS-NPCRKGATCINGVNGFRCICPEG 711
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
456-492 1.71e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.71e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     456 DINECHS-DPCQNDATCLDKIGGFTCLCMPGFK-GVHCE 492
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 987-1022 1.75e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.75e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  987 NINECTESS-CFNGGTCVDGINSFSCLCPVGFTGSFC 1022
Cdd:cd00054    1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1968-2096 2.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1968 ADVNAVDDH-GKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLP 2046
Cdd:PHA02878  158 ADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 55665845  2047 RDVARDR-MHHDIVRLLDEYNVTPSPPGTVLT-SALSPVICGPNRSFLSLKH 2096
Cdd:PHA02878  238 LHISVGYcKDYDILKLLLEHGVDVNAKSYILGlTALHSSIKSERKLKLLLEY 289
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1872-2046 2.11e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.09  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1872 QTDRTGEMALHLAARYSRADAAKRLLD-AGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDL-----DARMNDGT 1945
Cdd:cd22192   12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA-APELvnepmTSDLYQGE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1946 TPLILAARLAVEGMVAELINCQADVN--------------AVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEE 2011
Cdd:cd22192   91 TALHIAVVNQNLNLVRELIARGADVVspratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 55665845 2012 TPLFLAAREGSYEAAKILLDHFANRDITDH---MDRLP 2046
Cdd:cd22192  171 TVLHILVLQPNKTFACQMYDLILSYDKEDDlqpLDLVP 208
EGF_CA smart00179
Calcium-binding EGF-like domain;
757-793 2.12e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.12e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     757 DKNECLS-NPCQNGGTCDNLVNGYRCTCKKGFK-GYNCQ 793
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 795-831 3.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 3.38e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  795 NIDECAS-NPCLNQGTCFDDISGYTCHCVLPYTGKNCQ 831
Cdd:cd00054    1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1927-2064 3.87e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 3.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1927 QILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGA----- 2001
Cdd:PHA02874   18 EKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVdtsil 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2002 -----NRDM-------------QDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLLD 2063
Cdd:PHA02874   98 pipciEKDMiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL 177


                  .
gi 55665845  2064 E 2064
Cdd:PHA02874  178 E 178
EGF_CA smart00179
Calcium-binding EGF-like domain;
494-530 3.90e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.90e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     494 EINECQS-NPCVNNGQCVDKVNRFQCLCPPGFT-GPVCQ 530
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
949-985 4.14e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.14e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     949 DMNECLSE-PCKNGGTCSDYVNSYTCKCQAGF-DGVHCE 985
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
Ank_5 pfam13857
Ankyrin repeats (many copies);
1873-1917 4.32e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.80  E-value: 4.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 55665845   1873 TDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAA 1917
Cdd:pfam13857   12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
EGF_CA smart00179
Calcium-binding EGF-like domain;
415-454 5.08e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 5.08e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 55665845     415 DVDECAManSNPCEHAGKCVNTDGAFHCECLKGY-AGPRCE 454
Cdd:smart00179    1 DIDECAS--GNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1225-1262 5.77e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 5.77e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1225 NIDDCARGPHCLNGGQCMDRIGGYSCRCLPGF-AGERCE 1262
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1187-1223 8.55e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 8.55e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1187 EVDECQ-NQPCQNGGTCIDLVNHFKCSCPPG-TRGLLCE 1223
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
608-643 1.33e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.33e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 55665845     608 IDECYS-SPCLNDGRCIDLVNGYQCNCQPG-TSGVNCE 643
Cdd:smart00179    2 IDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1822-2014 1.44e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.99  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1822 NVRGPDGCTPLMLASLRGGSSDLsdedEDAEDSSaNIITDLVYqgaslqaqtdRTGEMALHLAARYSRADAAKRLLDAGA 1901
Cdd:PHA02875   62 DVKYPDIESELHDAVEEGDVKAV----EELLDLG-KFADDVFY----------KDGMTPLHLATILKKLDIMKLLIARGA 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1902 DANAQDNMGRCPLHAAVAADAQGVFQILIRNRVTdLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSAL 1981
Cdd:PHA02875  127 DPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKAC-LDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 55665845  1982 HWAAAVNN-VEATLLLLKNGANRD---MQDNKEETPL 2014
Cdd:PHA02875  206 LCYAIENNkIDIVRLFIKRGADCNimfMIEGEECTIL 242
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 185-216 1.51e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.00  E-value: 1.51e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 55665845  185 ECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQ 216
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1463-1497 1.66e-05

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 43.67  E-value: 1.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 55665845   1463 WANCSSPlPCWDYINN-QCDELCNTVECLFDNFECQ 1497
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNgVCDEECNNAECLWDGGDCS 35
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1877-2025 2.05e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.01  E-value: 2.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1877 GEMALHLAARYSRADAAKRLLDAGAD-----ANAQDNMGRCPLHAAVAADAQGVFQILIRN-------RVTDLDARMND- 1943
Cdd:cd22192   51 GETALHVAALYDNLEAAVVLMEAAPElvnepMTSDLYQGETALHIAVVNQNLNLVRELIARgadvvspRATGTFFRPGPk 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1944 -----GTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEAT-----LLL----LKNGANRDMQDNK 2009
Cdd:cd22192  131 nliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFAcqmydLILsydkEDDLQPLDLVPNN 210

                        170
                 ....*....|....*..
gi 55665845 2010 EE-TPLFLAAREGSYEA 2025
Cdd:cd22192  211 QGlTPFKLAAKEGNIVM 227
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 260-296 2.58e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.58e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  260 NIDDC-PNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCT 296
Cdd:cd00054    1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 298-335 2.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 2.60e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 55665845  298 DVDECLlQPNACQNGGTCANRNGGYGCVCVNGWSGDDC 335
Cdd:cd00054    1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1029-1059 2.67e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 2.67e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845   1029 CSSHPCLNEGTCVDGLGTYRCSCPLGYTGKN 1059
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
911-947 2.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.83e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     911 DIDDCL-ANPCQNGGSCMDGVNTFSCLCLPGFT-GDKCQ 947
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
532-568 2.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 2.92e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     532 DIDDCSST-PCLNGAKCIDHPNGYECQCATGFT-GVLCE 568
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
987-1022 3.38e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 3.38e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 55665845     987 NINECTESS-CFNGGTCVDGINSFSCLCPVGFT-GSFC 1022
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1880-1930 3.67e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 3.67e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 55665845   1880 ALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILI 1930
Cdd:pfam13637    4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1963-2032 3.92e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 3.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1963 LINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDH 2032
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02946 PHA02946
ankyin-like protein; Provisional
 1859-2016 4.97e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.51  E-value: 4.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1859 ITDLVYQGASlQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQIlirNRVTDLD 1938
Cdd:PHA02946   55 VEELLHRGYS-PNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIERI---NLLVQYG 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1939 ARMN-----DGTTPLiLAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLL--LLKNGANRDMQDNKEE 2011
Cdd:PHA02946  131 AKINnsvdeEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIHRHLMSDNPKASTIswMMKLGISPSKPDHDGN 209


                  ....*
gi 55665845  2012 TPLFL 2016
Cdd:PHA02946  210 TPLHI 214
EGF_CA pfam07645
Calcium-binding EGF domain;
182-212 5.20e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 5.20e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    182 DVNECDIPGH-CQHGGTCLNLPGSYQCQCPQG 212
Cdd:pfam07645    1 DVDECATGTHnCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 536-564 8.92e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 8.92e-05
                           10        20
                   ....*....|....*....|....*....
gi 55665845    536 CSSTPCLNGAKCIDHPNGYECQCATGFTG 564
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1948-2062 9.50e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 47.94  E-value: 9.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1948 LILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLF------------ 2015
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWnaisakhhkifr 608

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845  2016 -------------------LAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRLL 2062
Cdd:PLN03192  609 ilyhfasisdphaagdllcTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLL 674
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1877-2044 1.05e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 47.83  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1877 GEMALHLAARYSRADAAKRLLDAGADANAQdnmgrcplhaavaadAQGVFqilirnrvtdLDARMND-----GTTPLILA 1951
Cdd:cd22194  141 GQTALNIAIERRQGDIVKLLIAKGADVNAH---------------AKGVF----------FNPKYKHegfyfGETPLALA 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1952 ARLAVEGMVAELI-NCQADVNAVDDHGKSALH-----------WAAAVNNVEATLLLLKNGANRDMQDNKEE-TPLFLAA 2018
Cdd:cd22194  196 ACTNQPEIVQLLMeKESTDITSQDSRGNTVLHalvtvaedsktQNDFVKRMYDMILLKSENKNLETIRNNEGlTPLQLAA 275

                        170       180
                 ....*....|....*....|....*.
gi 55665845 2019 REGSYEaakiLLDHFANRDITDHMDR 2044
Cdd:cd22194  276 KMGKAE----ILKYILSREIKEKPNR 297
EGF_CA smart00179
Calcium-binding EGF-like domain;
795-831 1.42e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.42e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     795 NIDECAS-NPCLNQGTCFDDISGYTCHCVLPYT-GKNCQ 831
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
1944-1997 1.50e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 1.50e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 55665845   1944 GTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNNVEATLLLL 1997
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 799-829 1.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 1.70e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    799 CASNPCLNQGTCFDDISGYTCHCVLPYTGKN 829
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PHA03378 PHA03378
EBNA-3B; Provisional
 2272-2424 2.72e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.60  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2272 LAPAEGTHPG-IAPQSRPPEGkhiTTPRE---PLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMAR 2347
Cdd:PHA03378  598 PVPHPSQTPEpPTTQSHIPET---SAPRQwpmPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPY 674

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845  2348 LPSVAFPTAMMPQQDG-QVAQTilPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQgeHPYLTPSPESPDQ 2424
Cdd:PHA03378  675 QPSPTGANTMLPIQWApGTMQP--PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRAR--PPAAAPGRARPPA 748
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
2273-2444 3.63e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2273 APAEGThPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQST--------CPPAVAGPLPTMYQIPE 2344
Cdd:PRK12323  400 AAPPAA-PAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPApaaapaaaARPAAAGPRPVAAAAAA 478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2345 MARLPSVAFPTAmmPQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEHPYLTPSPESPDQ 2424
Cdd:PRK12323  479 APARAAPAAAPA--PADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAA 556

                         170       180
                  ....*....|....*....|
gi 55665845  2425 WSSSSPHSASDWSDVTTSPT 2444
Cdd:PRK12323  557 TEPVVAPRPPRASASGLPDM 576
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1153-1183 3.70e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 3.70e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845   1153 CASNPCQHGATCSDFIGGYRCECVPGYQGVN 1183
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 498-527 4.17e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.17e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 55665845    498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGP 527
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 915-944 4.25e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.25e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 55665845    915 CLANPCQNGGSCMDGVNTFSCLCLPGFTGD 944
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 192-217 5.07e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.07e-04
                           10        20
                   ....*....|....*....|....*.
gi 55665845    192 CQHGGTCLNLPGSYQCQCPQGFTGQY 217
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
298-335 5.09e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.09e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     298 DVDECLlQPNACQNGGTCANRNGGYGCVCVNGWS-GDDC 335
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 1814-2050 6.38e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 45.17  E-value: 6.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1814 QEVDVLDVNVRGPD-GCTPLMLA--SLRGGSSDLS------DEDEDAEDSSANI-ITDLVYQGASlqaqtdrtgemALHL 1883
Cdd:cd22193   14 RRKDLTDSEFTESStGKTCLMKAllNLNPGTNDTIrilldiAEKTDNLKRFINAeYTDEYYEGQT-----------ALHI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1884 AARYSRADAAKRLLDAGADANAQdnmgrcplhaavaadAQGVFqilirNRVTDLDARMNDGTTPLILAA---RLAVEGMV 1960
Cdd:cd22193   83 AIERRQGDIVALLVENGADVHAH---------------AKGRF-----FQPKYQGEGFYFGELPLSLAActnQPDIVQYL 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1961 AELINCQADVNAVDDHGKSALHWAAAV--NNVEATLL-------LLKNGAN-------RDMQDNKEETPLFLAAREGSYE 2024
Cdd:cd22193  143 LENEHQPADIEAQDSRGNTVLHALVTVadNTKENTKFvtrmydmILIRGAKlcptvelEEIRNNDGLTPLQLAAKMGKIE 222

                        250       260       270
                 ....*....|....*....|....*....|
gi 55665845 2025 aakiLLDHFANRDITD----HMDRLPRDVA 2050
Cdd:cd22193  223 ----ILKYILQREIKEpelrHLSRKFTDWA 248
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1982-2070 6.75e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.89  E-value: 6.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1982 HWAAAVNNVEATLLLlKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITDHMDRLPRDVARDRMHHDIVRL 2061
Cdd:PTZ00322   88 QLAASGDAVGARILL-TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  ....*....
gi 55665845  2062 LDEYNVTPS 2070
Cdd:PTZ00322  167 LSRHSQCHF 175
EGF_CA pfam07645
Calcium-binding EGF domain;
682-711 7.23e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 7.23e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    682 DIDECAS--NPCRKGATCINGVNGFRCICPEG 711
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 645-679 7.28e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 7.28e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  645 NFDDCAS-NPC-IHGICMDGINRYSCVCSPGFTGQRC 679
Cdd:cd00054    1 DIDECASgNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 761-789 7.58e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.58e-04
                           10        20
                   ....*....|....*....|....*....
gi 55665845    761 CLSNPCQNGGTCDNLVNGYRCTCKKGFKG 789
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1152-1185 7.77e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 7.77e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 55665845 1152 ECA-SNPCQHGATCSDFIGGYRCECVPGYQGV-NCE 1185
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 953-983 9.60e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 9.60e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    953 CLSEPCKNGGTCSDYVNSYTCKCQAGFDGVH 983
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1028-1061 1.04e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 1.04e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 55665845 1028 ECS-SHPCLNEGTCVDGLGTYRCSCPLGYTG-KNCQ 1061
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 570-604 1.18e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.18e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 55665845  570 NIDNCD-PDPC-HHGQCQDGIDSYTCICNPGYMGAIC 604
Cdd:cd00054    1 DIDECAsGNPCqNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
260-296 1.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.21e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845     260 NIDDC-PNHRCQNGGVCVDGVNTYNCRCPPQWT-GQFCT 296
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1874-2037 1.33e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1874 DRTGE-----MALHLAARYSRADAA--KRLLDAGADANAQDNMGRCPLHAAVAADAQGVFQILIRNrVTDLDARMNDGTT 1946
Cdd:PLN03192  515 DNGGEhddpnMASNLLTVASTGNAAllEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKH-ACNVHIRDANGNT 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1947 PLILAARLAVEGMVAELINCQAdvnAVDDH-GKSALHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEA 2025
Cdd:PLN03192  594 ALWNAISAKHHKIFRILYHFAS---ISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDM 670

                         170
                  ....*....|..
gi 55665845  2026 AKILLDHFANRD 2037
Cdd:PLN03192  671 VRLLIMNGADVD 682
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1459-1496 1.35e-03

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 38.46  E-value: 1.35e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 55665845    1459 MENPWANCSSPlPCWDYINN-QCDELCNTVECLFDNFEC 1496
Cdd:smart00004    1 PQDPWSRCEDA-QCWDKFGDgVCDEECNNAECLWDGGDC 38
EGF_CA pfam07645
Calcium-binding EGF domain;
873-902 1.53e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.53e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    873 DIDECIS--KPCMNHGLCHNTQGSYMCECPPG 902
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1312-1343 1.54e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.54e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 55665845 1312 PCLNGGTCavaSNMPDGFICRCPPGFSGARCQ 1343
Cdd:cd00054   10 PCQNGGTC---VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1191-1219 1.84e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.84e-03
                           10        20
                   ....*....|....*....|....*....
gi 55665845   1191 CQNQPCQNGGTCIDLVNHFKCSCPPGTRG 1219
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 460-490 2.17e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.17e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    460 CHSDPCQNDATCLDKIGGFTCLCMPGFKGVH 490
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 877-905 2.44e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.44e-03
                           10        20
                   ....*....|....*....|....*....
gi 55665845    877 CISKPCMNHGLCHNTQGSYMCECPPGFSG 905
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA pfam07645
Calcium-binding EGF domain;
456-485 2.45e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 2.45e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    456 DINECHS--DPCQNDATCLDKIGGFTCLCMPG 485
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 876-905 2.71e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.71e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 55665845  876 EC-ISKPCMNHGLCHNTQGSYMCECPPGFSG 905
Cdd:cd00053    1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 760-789 2.79e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.79e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 55665845  760 EC-LSNPCQNGGTCDNLVNGYRCTCKKGFKG 789
Cdd:cd00053    1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1196-1216 2.82e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.93  E-value: 2.82e-03
                           10        20
                   ....*....|....*....|.
gi 55665845   1196 CQNGGTCIDLVNHFKCSCPPG 1216
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPG 21
EGF_CA pfam07645
Calcium-binding EGF domain;
298-329 2.86e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.22  E-value: 2.86e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 55665845    298 DVDECLLQPNACQNGGTCANRNGGYGCVCVNG 329
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1117-1147 2.89e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 2.89e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 55665845 1117 EHLCQHSGVCINAGNTHYCQCPLGYTGSYCE 1147
Cdd:cd00054    8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1976-2008 2.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1976 HGKSALHWAAA-VNNVEATLLLLKNGANRDMQDN 2008
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1877-1908 2.96e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 2.96e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 55665845   1877 GEMALHLAA-RYSRADAAKRLLDAGADANAQDN 1908
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 497-527 3.17e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 3.17e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 55665845  497 ECQ-SNPCVNNGQCVDKVNRFQCLCPPGFTGP 527
Cdd:cd00053    1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1228-1260 3.27e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 3.27e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 55665845 1228 DCARGPHCLNGGQCMDRIGGYSCRCLPGFAGER 1260
Cdd:cd00053    1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1264-1302 3.55e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.55e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 55665845 1264 DINECLS-NPCSSEGSldCIQLTNDYLCVCRSAFTGRHCE 1302
Cdd:cd00054    1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF smart00181
Epidermal growth factor-like domain;
185-216 3.94e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.11  E-value: 3.94e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 55665845     185 ECDIPGHCQHGgTCLNLPGSYQCQCPQGFTGQ 216
Cdd:smart00181    1 ECASGGPCSNG-TCINTPGSYTCSCPPGYTGD 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 192-213 4.34e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 4.34e-03
                           10        20
                   ....*....|....*....|..
gi 55665845    192 CQHGGTCLNLPGSYQCQCPQGF 213
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 611-641 4.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    611 CYSSPCLNDGRCIDLVNGYQCNCQPGTSGVN 641
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 423-452 4.96e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.96e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 55665845    423 NSNPCEHAGKCVNTDGAFHCECLKGYAGPR 452
Cdd:pfam00008    2 APNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Ank_5 pfam13857
Ankyrin repeats (many copies);
1929-1984 5.08e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 5.08e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 55665845   1929 LIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWA 1984
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02887 PHA02887
EGF-like protein; Provisional
 629-681 5.24e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 39.14  E-value: 5.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 55665845   629 YQCNCQPGTSGVNCEINFDDCAS---NPCIHGICMDGIN--RYSCVCSPGFTGQRCNI 681
Cdd:PHA02887   66 YKENANAQNFKRKNSMFFEKCKNdfnDFCINGECMNIIDldEKFCICNKGYTGIRCDE 123
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1766-1942 5.54e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 5.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1766 PKKVKAEDEALLSEEDDPIDrrpwtqQHLEAadIRRTPSLALTPPQAEQEVDVLDvnvrgpdgctPLMLASLrggSSDLS 1845
Cdd:PTZ00322   29 AKPISFERMAAIQEEIARID------THLEA--LEATENKDATPDHNLTTEEVID----------PVVAHML---TVELC 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1846 DEDEDAEDSSANIitdLVYQGASLQAQtDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAADAQGV 1925
Cdd:PTZ00322   88 QLAASGDAVGARI---LLTGGADPNCR-DYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163

                         170
                  ....*....|....*..
gi 55665845  1926 FQILIRNRVTDLDARMN 1942
Cdd:PTZ00322  164 VQLLSRHSQCHFELGAN 180
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
2269-2422 5.94e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 5.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  2269 GMVLAPAEGTHPGIAPQSRPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGAPQPQSTCPPAVAGPLPTMYQIPEMARL 2348
Cdd:PRK07003  378 GAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARA 457

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 55665845  2349 PSVAFPTAMMPQQDGQVAQTILPAyHPFPASVGKYPTPPSQHSYASSNAAERTPSHSGHLQGEH---PYLTPSPESP 2422
Cdd:PRK07003  458 SADSRCDERDAQPPADSGSASAPA-SDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDapaAAAPPAPEAR 533
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 991-1021 6.79e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 6.79e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    991 CTESSCFNGGTCVDGINSFSCLCPVGFTGSF 1021
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 918-945 6.98e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.98e-03
                         10        20
                 ....*....|....*....|....*...
gi 55665845  918 NPCQNGGSCMDGVNTFSCLCLPGFTGDK 945
Cdd:cd00053    6 NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
PHA02946 PHA02946
ankyin-like protein; Provisional
 1942-2072 7.22e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.58  E-value: 7.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845  1942 NDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSALHWAAAVNN--VEATLLLLKNGANRDMQDNKEETPLFLAAR 2019
Cdd:PHA02946   70 DDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYGAKINNSVDEEGCGPLLACT 149

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 55665845  2020 EGSYEAAKILLDHFANRDITDHM--DRLPRDVARDRMHHDIVRLLDEYNVTPSPP 2072
Cdd:PHA02946  150 DPSERVFKKIMSIGFEARIVDKFgkNHIHRHLMSDNPKASTISWMMKLGISPSKP 204
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1308-1341 7.87e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.87e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 55665845   1308 CPQMPCLNGGTCavaSNMPDGFICRCPPGFSGAR 1341
Cdd:pfam00008    1 CAPNPCSNGGTC---VDTPGGYTCICPEGYTGKR 31
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 1877-2044 8.96e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 41.33  E-value: 8.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1877 GEMALHLAARYSRADAAKRLLDAGADANAQdnmgrcplhaavaadAQGVFQILIRNRvtdldARMNDGTTPLILAA---R 1953
Cdd:cd22196   94 GQTALHIAIERRNMHLVELLVQNGADVHAR---------------ASGEFFKKKKGG-----PGFYFGELPLSLAActnQ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55665845 1954 LAVEGMVAELINCQADVNAVDDHGKSALHWAAAV--NNVEAT---------LLLLKNGAN-----RDMQDNKEETPLFLA 2017
Cdd:cd22196  154 LDIVKFLLENPHSPADISARDSMGNTVLHALVEVadNTPENTkfvtkmyneILILGAKIRpllklEEITNKKGLTPLKLA 233

                        170       180       190
                 ....*....|....*....|....*....|.
gi 55665845 2018 AREGSYEaakiLLDHFANRDITD----HMDR 2044
Cdd:cd22196  234 AKTGKIG----IFAYILGREIKEpecrHLSR 260
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 649-678 9.13e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 9.13e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 55665845    649 CASNPCIH-GICMDGINRYSCVCSPGFTGQR 678
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 264-292 9.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 9.40e-03
                           10        20
                   ....*....|....*....|....*....
gi 55665845    264 CPNHRCQNGGVCVDGVNTYNCRCPPQWTG 292
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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